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DPH5 Gene

protein-coding   GIFtS: 52
GCID: GC01M101455

Diphthamide Biosynthesis 5

(Previous name: DPH5 homolog (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Diphthamide Biosynthesis 51 2     CGI-302
Diphthamide Biosynthesis Methyltransferase2 3     NPD0152
EC 2.1.1.983 8     Diphthine Synthase2
HSPC1432 5     DPH5 Homolog2
DPH5 Homolog (S. Cerevisiae)1     Protein X 00112

External Ids:    HGNC: 242701   Entrez Gene: 516112   Ensembl: ENSG000001175437   OMIM: 6110755   UniProtKB: Q9H2P93   
ORGUL members:         

Export aliases for DPH5 gene to outside databases

Previous GC identifers: GC01M101168 GC01M101227 GC01M099580


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPH5 Gene:
This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified
histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans,
and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and
Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation
factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPH5 Gene:
DPH5 (diphthamide biosynthesis 5) is a protein-coding gene. GO annotations related to this gene include diphthine synthase activity.

UniProtKB/Swiss-Prot: DPH5_HUMAN, Q9H2P9
Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group
of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate
called diphthine. The three successive methylation reactions represent the second step of diphthamide
biosynthesis

Gene Wiki entry for DPH5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPH5 gene promoter:
         c-Fos   AP-1   ATF-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   GATA-1   Chx10   c-Jun   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPH5 promoter sequence
   Search Chromatin IP Primers for DPH5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p21.2   Ensembl cytogenetic band:  1p21.2   HGNC cytogenetic band: 1p21.2

DPH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPH5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M101455:  view genomic region     (about GC identifiers)

Start:
101,455,179 bp from pter      End:
101,491,644 bp from pter
Size:
36,466 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPH5_HUMAN, Q9H2P9 (See protein sequence)
Recommended Name: Diphthine synthase  
Size: 285 amino acids; 31651 Da
Secondary accessions: A8JZY6 D3DT62 Q9P017 Q9P0I4 Q9Y319
Alternative splicing: 6 isoforms:  Q9H2P9-1   Q9H2P9-2   Q9H2P9-3   Q9H2P9-4   Q9H2P9-5   Q9H2P9-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DPH5: NX_Q9H2P9

Explore proteomics data for DPH5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DPH5 (Q9H2P9) (see all 7)
     ATTHSDL  DITVKGLE  RVYLEAYT  GLQLYKFG 


    See DPH5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001070862.1  NP_001070863.1  NP_057042.2  

    ENSEMBL proteins: 
     ENSP00000359127   ENSP00000339630   ENSP00000418282   ENSP00000394364  

    DPH5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DPH5

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR014777 4pyrrole_Mease_sub1
     IPR014776 4pyrrole_Mease_sub2
     IPR004551 Dphthn_synthase
     IPR000878 4pyrrol_Mease

    Graphical View of Domain Structure for InterPro Entry Q9H2P9

    ProtoNet protein and cluster: Q9H2P9

    UniProtKB/Swiss-Prot: DPH5_HUMAN, Q9H2P9
    Similarity: Belongs to the diphthine synthase family


    Find genes that share domains with DPH5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPH5_HUMAN, Q9H2P9
    Function: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group
    of the modified target histidine residue in translation elongation factor 2 (EEF2), to form an intermediate
    called diphthine. The three successive methylation reactions represent the second step of diphthamide
    biosynthesis
    Catalytic activity: 3 S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation
    factor 2] = 3 S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine-[translation
    elongation factor 2]

         Enzyme Number (IUBMB): EC 2.1.1.981 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004164diphthine synthase activity NAS15485916
    GO:0008168methyltransferase activity ----
         
    Find genes that share ontologies with DPH5           About GenesLikeMe


    Animal Models:
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    miRTarBase miRNAs that target DPH5:
    hsa-mir-769-5p (MIRT039181), hsa-let-7a-5p (MIRT052597), hsa-mir-124-3p (MIRT022425)

    Block miRNA regulation of human, mouse, rat DPH5 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DPH5:
    hsa-miR-548am hsa-miR-144* hsa-miR-548x hsa-miR-145 hsa-miR-3682-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidDPH5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPH5

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    GenScript: all cDNA clones in your preferred vector (see all 3): DPH5 (NM_001077395)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with DPH5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DPH5 About    
    See pathways by source

    SuperPathContained pathways About
    1diphthamide biosynthesis
    diphthamide biosynthesis


    1 BioSystems Pathway for DPH5
        diphthamide biosynthesis


    UniProtKB/Swiss-Prot: DPH5_HUMAN, Q9H2P9
    Pathway: Protein modification; peptidyl-diphthamide biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPH5
    Interactions:

        Search GeneGlobe Interaction Network for DPH5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for DPH5 (Q9H2P93 ENSP000003591274) via UniProtKB, MINT, STRING, and/or I2D (see all 59)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF2P136393, ENSP000003079404I2D: score=6 STRING: ENSP00000307940
    PMPCAQ107133, ENSP000003607824I2D: score=2 STRING: ENSP00000360782
    COPB1P536183, ENSP000002499234I2D: score=1 STRING: ENSP00000249923
    PMPCBO754393, ENSP000002492694I2D: score=1 STRING: ENSP00000249269
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine NAS15485916

    Find genes that share ontologies with DPH5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPH5

    4 HMDB Compounds for DPH5    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-(3-Carboxy-3-(methylammonio)propyl)-L-histidine[3-[[4-(2-amino-2-carboxy-ethyl)-1H-imidazol-2-yl]]-1-carboxy- propyl]-methyl-ammonium (see all 4)----
    2-(3-Carboxy-3-aminopropyl)-L-histidine2-(3-amino-3-carboxypropyl)-L-histidine (see all 3)----
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    1 DrugBank Compound for DPH5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    S-Adenosyl-L-Homocysteine-- 979-92-0target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPH5 gene (3 alternative transcripts): 
    NM_001077394.1  NM_001077395.1  NM_015958.2  

    Unigene Cluster for DPH5:

    DPH5 homolog (S. cerevisiae)
    Hs.440776  [show with all ESTs]
    Unigene Representative Sequence: AK125485
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370105(uc001dtr.2 uc001dts.2 uc001dtt.2 uc001dtw.2 uc001dty.2 uc001dtq.2 uc001dtz.2)
    ENST00000492067 ENST00000370109 ENST00000488789 ENST00000481871 ENST00000464270
    ENST00000342173 ENST00000466807 ENST00000477293 ENST00000498372 ENST00000488176
    ENST00000490732 ENST00000476507 ENST00000481982 ENST00000427040
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate DPH5:
    hsa-miR-548am hsa-miR-144* hsa-miR-548x hsa-miR-145 hsa-miR-3682-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidDPH5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPH5
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    GenScript: all cDNA clones in your preferred vector (see all 3): DPH5 (NM_001077395)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPH5
      QuantiTect SYBR Green Assays in human, mouse, rat DPH5
      QuantiFast Probe-based Assays in human, mouse, rat DPH5

    Additional mRNA sequence: 

    AF157319.1 AF161492.1 AF248965.1 AK125485.1 AK225469.1 AK225707.1 AK225951.1 AK289351.1 
    AK298181.1 BC009620.2 BC034669.1 BC053857.1 

    24 DOTS entries:

    DT.100846276  DT.100027982  DT.100846287  DT.91762831  DT.100846295  DT.121442666  DT.100846285  DT.101985139 
    DT.121442740  DT.92444606  DT.100846278  DT.92444590  DT.95089453  DT.95341278  DT.92444596  DT.95341257 
    DT.100846277  DT.100846283  DT.121442735  DT.121442748  DT.75149994  DT.75161435  DT.95341260  DT.121442777 

    Selected AceView cDNA sequences (see all 205):

    BI764781 AA574108 BG743531 CR594915 CR597128 BM726683 AA385447 BX342949 
    BX401217 AU099517 N81101 AW352106 AA541271 BI828210 BQ652966 BQ347412 
    BQ009034 CR615163 R54926 AA405666 BC009620 BQ427548 AI203776 BU855880 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DPH5 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                                            -           -     -                       -     -                                       
    SP2:                                      -     -           -     -                       -     -                                       
    SP3:                                      -     -     -     -     -                       -                                             
    SP4:                                      -     -     -     -     -                       -     -                                       
    SP5:                                            -           -     -                 -     -     -     -                                 


    ECgene alternative splicing isoforms for DPH5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGTAAC
    DPH5 Expression
    About this image

    DPH5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPH5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440776
        Custom PCR Arrays for DPH5
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DPH5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPH5 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dph51 , 5 DPH5 homolog (S. cerevisiae)1, 5 87.19(n)1
    92.17(a)1
      3 (50.13 cM)5
    697401  NM_027193.21  NP_081469.21 
     1158881655 
    chicken
    (Gallus gallus)
    Aves DPH51 DPH5 homolog (S. cerevisiae) 76.16(n)
    80.78(a)
      424463  XM_422306.4  XP_422306.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPH56
    diphthamide biosynthesis 5
    77(a)
    1 ↔ 1
    4(87405300-87456804)
    African clawed frog
    (Xenopus laevis)
    Amphibia cgi-30-prov2 CGI-30 protein 76.55(n)    BC054245.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dph51 DPH5 homolog (S. cerevisiae) 69.96(n)
    78.75(a)
      100003898  NM_001100085.1  NP_001093555.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dph51 Diphthamide methyltransferase 59.9(n)
    63.47(a)
      42663  NM_079728.5  NP_524452.4 
    worm
    (Caenorhabditis elegans)
    Secernentea B0491.71 B0491.7 61.09(n)
    63.94(a)
      174737  NM_064026.1  NP_496427.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DPH51 DPH5 58.43(n)
    58.43(a)
      850869   NP_013273.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G317901 AT4G31790 63.77(n)
    61.13(a)
      829307  NM_202926.2  NP_974655.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03558001 Os03g0355800 58.8(n)
    60.3(a)
      4332866  NM_001056672.1  NP_001050137.1 


    ENSEMBL Gene Tree for DPH5 (if available)
    TreeFam Gene Tree for DPH5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPH5 (see all 543)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887791771,2
    --101455230(+) TAACAC/TTTTTT 3 -- ut310--------
    rs171235811,2
    C,F,H--101455409(+) TCCTGA/GAAATT 3 -- ut3111Minor allele frequency- G:0.02NA NS EA 1164
    rs1916772711,2
    --101455484(+) GCATTA/GTTGAG 3 -- ut310--------
    rs1853348161,2
    --101455789(+) GAAAGC/TTCACT 3 -- ut310--------
    rs115466451,2
    F--101455876(+) AAATTC/TAAGAT 3 -- ut311Minor allele frequency- T:0.06MN 184
    rs3769301971,2
    C--101455945(+) TCAGAC/TAATGG 3 -- ut310--------
    rs2013027751,2
    C--101456010(+) GTATGA/GAAAAC 6 S F mis10--------
    rs2001906221,2
    --101456031(+) TCTCCA/CTCTCC 6 R M mis10--------
    rs38353961,2
    C--101456676(-) GAGTA-/ATTACA 3 -- int10--------
    rs1898390221,2
    --101456716(+) AGATAA/GTAGAT 3 -- int10--------

    HapMap Linkage Disequilibrium report for DPH5 (101455179 - 101491644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DPH5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2668878CNV Deletion23128226
    nsv522064CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPH5
    DNA2.0 Custom Variant and Variant Library Synthesis for DPH5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611075    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DPH5:
    Diphtheria

    Find genes that share disorders with DPH5           About GenesLikeMe

    Genetic Association Database (GAD): DPH5

    Export disorders for DPH5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPH5 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with DPH5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. (PubMed id 23486472)1, 2, 3 Wei H....Pastan I. (J. Biol. Chem. 2013)
    2. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PubMed id 15485916)1, 3, 9 Liu S....Leppla S.H. (Mol. Cell. Biol. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    7. Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. (PubMed id 23459443)1 Avery C.L....Psaty B.M. (Pharmacogenomics J. 2013)
    8. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51611 HGNC: 24270 AceView: CGI-30 Ensembl:ENSG00000117543 euGenes: HUgn51611
    ECgene: DPH5 H-InvDB: DPH5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPH5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPH5 gene:
    Search GeneIP for patents involving DPH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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