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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPH3 Gene

protein-coding   GIFtS: 44
GCID: GC03M016298

Diphthamide Biosynthesis 3

(Previous names: zinc finger, CSL-type containing 2, DPH3 homolog (KTI11,...)
(Previous symbol: ZCSL2)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Diphthamide Biosynthesis 31 2     KTI11 Homolog A (S. Cerevisiae)1
ZCSL21 2 3 5     DELGIP2
DPH3 Homolog (KTI11, S. Cerevisiae)1 2     Deafness Locus Putative Guanine Nucleotide Exchange Factor Interacting
Protein 12
Zinc Finger, CSL-Type Containing 21 2     Del-GEF Interacting Protein2
DPH3A1 2     Diphtheria Toxin And Pseudomonas Exotoxin A Sensitivity Required Gene 12
DelGEF-Interacting Protein 12 3     DPH3 Homolog2
DESR12 3     DPH3, KTI11 Homolog2
CSL-Type Zinc Finger-Containing Protein 22 3     DPH3A, KTI11 Homolog A2
DELGIP12 5     Zinc Finger, CSL Domain Containing 22
KTI112 5     DelGIP13
DPH3, KTI11 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 277171   Entrez Gene: 2853812   Ensembl: ENSG000001548137   OMIM: 6089595   UniProtKB: Q96FX23   

Export aliases for DPH3 gene to outside databases

Previous GC identifer: GC03M016277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPH3 Gene:
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded
protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to
diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and
Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same
isoform. (provided by RefSeq, Feb 2009)

GeneCards Summary for DPH3 Gene: 
DPH3 (diphthamide biosynthesis 3) is a protein-coding gene. Diseases associated with DPH3 include diphtheria. GO annotations related to this gene include protein binding and metal ion binding.

UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2
Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of
histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by
Pseudomonas exotoxin A (By similarity)
Function: Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the
secretion process. Stimulates binding of GNEFR to SEC5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPH3 gene promoter:
         Pbx1a   HTF   AREB6   CREB   E2F   E2F-1   deltaCREB   FOXJ2 (long isoform)   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

DPH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPH3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016298:  view genomic region     (about GC identifiers)

Start:
16,298,568 bp from pter      End:
16,306,496 bp from pter
Size:
7,929 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2 (See protein sequence)
Recommended Name: DPH3 homolog  
Size: 82 amino acids; 9240 Da
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for DPH3:
2JR7 (3D)    
Alternative splicing: 2 isoforms:  Q96FX2-1   Q96FX2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DPH3: NX_Q96FX2

Explore proteomics data for DPH3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FX2

  • DPH3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPH3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001040899.1  NP_996662.1  

    ENSEMBL proteins: 
     ENSP00000419599   ENSP00000373285  

    Human Recombinant Protein Products for DPH3: 
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    Novus Biologicals DPH3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DPH3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    DPH3 for ontologies           About GeneDecksing



    DPH3 Antibody Products: 
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    Assay Products for DPH3: 
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    Cloud-Clone Corp. ELISAs for DPH3 
    Cloud-Clone Corp. CLIAs for DPH3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007872 Znf_DHP

    Graphical View of Domain Structure for InterPro Entry Q96FX2

    ProtoNet protein and cluster: Q96FX2

    UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2
    Similarity: Belongs to the DPH3 family
    Similarity: Contains 1 DPH-type zinc finger


    DPH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPH3_HUMAN, Q96FX2
    Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of
    histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by
    Pseudomonas exotoxin A (By similarity)
    Function: Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the
    secretion process. Stimulates binding of GNEFR to SEC5

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14980502
    GO:0046872metal ion binding IEA--
         
    DPH3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dph3):
     cardiovascular system  embryogenesis  growth/size  mortality/aging  nervous system 

    DPH3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dph3tm1Lepp for DPH3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPH3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DPH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPH3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPH3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPH3
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate DPH3 (see all 33):
    hsa-let-7d hsa-let-7a-2* hsa-miR-29b-1* hsa-let-7g hsa-miR-183* hsa-miR-124 hsa-miR-1184 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDPH3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for DPH3
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for DPH3 (Q96FX21, 3 ENSP000004195994) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERGEFQ9UGK81, 3, ENSP000002659654EBI-465363,EBI-465368 I2D: score=2 STRING: ENSP00000265965
    ELP3ENSP000002563984STRING: ENSP00000256398
    DPH1ENSP000002630834STRING: ENSP00000263083
    ELP2ENSP000003509674STRING: ENSP00000350967
    IKBKAPENSP000003637794STRING: ENSP00000363779
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine ISS--
    GO:0050709negative regulation of protein secretion IDA14980502
    GO:0051099positive regulation of binding IDA14980502

    DPH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPH3

    Search CenterWatch for drugs/clinical trials and news about DPH3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPH3 gene (2 alternative transcripts): 
    NM_001047434.2  NM_206831.2  

    Unigene Cluster for DPH3:

    DPH3, KTI11 homolog (S. cerevisiae)
    Hs.388087  [show with all ESTs]
    Unigene Representative Sequence: NM_206831
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488423(uc003cat.4 uc003cau.3 uc003cav.3) ENST00000383775
    ENST00000285082 ENST00000462982
    miRNA
    Products:
         
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    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate DPH3 (see all 33):
    hsa-let-7d hsa-let-7a-2* hsa-miR-29b-1* hsa-let-7g hsa-miR-183* hsa-miR-124 hsa-miR-1184 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDPH3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPH3
    Clone
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    OriGene clones in human, mouse for DPH3 (see all 12)
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    GenScript: all cDNA clones in your preferred vector (see all 2): DPH3 (NM_206831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPH3
    Sirion Biotech Customized lentivirus for stable overexpression of DPH3 
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    OriGene qPCR primer pairs and template standards for DPH3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPH3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPH3

    Additional mRNA sequence: 

    AK022970.1 AK023203.1 AK092040.1 AK311618.1 BC010181.2 BC073931.1 BC094863.1 

    6 DOTS entries:

    DT.95262116  DT.100782472  DT.95257646  DT.92420590  DT.100734000  DT.100782473 

    24/194 AceView cDNA sequences (see all 194):

    BM452855 AA502392 AI097226 AA721309 BM550423 AI249053 BF063630 AW661665 
    BQ213445 AA777638 BM504521 AA865334 BM717191 N33756 NM_206831 BM834930 
    AI122599 BC010181 AA831174 C04626 BM549276 N80873 F12397 BF692547 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DPH3    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
    SP1:                          -     -                                       
    SP2:                          -     -                                       
    SP3:                                -                                       
    SP4:                                                                        
    SP5:                          -     -     -                                 


    ECgene alternative splicing isoforms for DPH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DPH3 Expression
    About this image


    See DPH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPH3

    SOURCE GeneReport for Unigene cluster: Hs.388087

    UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2
    Tissue specificity: Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DPH3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dph31 , 5 DPH3 homolog (KTI11, S. cerevisiae)1, 5 91.06(n)1
    96.34(a)1
      14 (19.40 cM)5
    1056381  NM_172254.31  NP_758458.11 
     320805665 
    chicken
    (Gallus gallus)
    Aves DPH31 DPH3, KTI11 homolog (S. cerevisiae) 70.46(n)
    75.95(a)
      420643  XM_418742.3  XP_418742.3 
    lizard
    (Anolis carolinensis)
    Reptilia DPH36
    Uncharacterized protein
    78(a)
    1 ↔ 1
    6(35086952-35090896)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1122311 zgc:112231 69.7(n)
    75.32(a)
      553692  NM_001159824.1  NP_001153296.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147011 CG14701 66.67(n)
    67.65(a)
      41352  NM_141800.2  NP_650057.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dph-31 Protein DPH-3 61.9(n)
    67.14(a)
      186854  NM_069325.1  NP_501726.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KTI116
    Zn-ribbon protein that co-purifies with Dph1 and D...
    39(a)
    1 ↔ 1
    II(89978-90226)


    ENSEMBL Gene Tree for DPH3 (if available)
    TreeFam Gene Tree for DPH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPH3 gene
    2 SIMAP similar genes for DPH3 using alignment to 1 protein entry:     DPH3_HUMAN:
    DPH3P1    DNAJC24

    DPH3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DPH3
    PGOHUM00000242102


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 SNPs in DPH3 are shown (see all 148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs759706511,2
    C,F--16298202(+) TTTGCA/TCTTCT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1409707571,2
    --16298208(+) CTTCTA/CATATT 2 -- ds50010--------
    rs778725931,2
    C,F--16298227(+) GAATAC/ATGTCA 2 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1430630741,2
    --16298231(+) ACTGTC/GAATGT 2 -- ds50010--------
    rs1474866721,2
    C--16298250(+) GCTTGA/GATATG 2 -- ds50010--------
    rs1392366481,2
    --16298278(+) TCATAC/TTGAGG 2 -- ds50010--------
    rs1829149601,2
    --16298296(+) CCCAAA/CGTAAT 2 -- ds50010--------
    rs609790591,2
    C,F--16298313(+) GAAAGA/TTGGTG 2 -- ds50013Minor allele frequency- T:0.29WA 122
    rs1395254871,2
    C--16298332(+) GAGGT-/TATTTG 2 -- ds50010--------
    rs1872126511,2
    --16298377(+) GACATA/CTGGTG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DPH3 (16298568 - 16306496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DPH3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876585CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608959    OMIM disorders: --

    2 diseases for DPH3:    About MalaCards
    diphtheria    

    1 disease from the University of Copenhagen DISEASES database for DPH3:
    Diphtheria

    DPH3 for disorders           About GeneDecksing


    Export disorders for DPH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPH3 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DPH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. (PubMed id 14980502)1, 2, 3, 9 Sjoelinder M.... Ponstingl H. (2004)
    2. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP- ribosylating toxins. (PubMed id 14527407)1, 2, 3 Liu S. and Leppla S.H. (2003)
    3. Solution structure of human DESR1, a CSL zinc-binding protein. (PubMed id 18214955)1, 2 Wu F....Shi Y. (2008)
    4. Dph3, a small protein required for diphthamide biosynt hesis, is essential in mouse development. (PubMed id 16648478)1, 3 Liu S....Leppla S.H. (2006)
    5. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PubMed id 15485916)1, 3 Liu S....Leppla S.H. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285381 HGNC: 27717 AceView: ZCSL2 Ensembl:ENSG00000154813 euGenes: HUgn285381
    ECgene: DPH3 H-InvDB: DPH3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPH3 gene:
    Search GeneIP for patents involving DPH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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