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Aliases for DPH3 Gene

Aliases for DPH3 Gene

  • Diphthamide Biosynthesis 3 2 3
  • DELGIP1 3 4 6
  • ZCSL2 3 4 6
  • CSL-Type Zinc Finger-Containing Protein 2 3 4
  • DPH3 Homolog (KTI11, S. Cerevisiae) 2 3
  • Zinc Finger, CSL-Type Containing 2 2 3
  • DelGEF-Interacting Protein 1 3 4
  • DPH3A 2 3
  • KTI11 3 6
  • DESR1 3 4
  • Deafness Locus Putative Guanine Nucleotide Exchange Factor Interacting Protein 1 3
  • Diphtheria Toxin And Pseudomonas Exotoxin A Sensitivity Required Gene 1 3
  • Zinc Finger, CSL Domain Containing 2 3
  • DPH3, KTI11 Homolog (S. Cerevisiae) 2
  • KTI11 Homolog A (S. Cerevisiae) 2
  • Del-GEF Interacting Protein 3
  • DPH3A, KTI11 Homolog A 3
  • DPH3, KTI11 Homolog 3
  • DPH3 Homolog 3
  • DELGIP 3

External Ids for DPH3 Gene

Previous Symbols for DPH3 Gene

  • ZCSL2

Summaries for DPH3 Gene

Entrez Gene Summary for DPH3 Gene

  • This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]

GeneCards Summary for DPH3 Gene

DPH3 (Diphthamide Biosynthesis 3) is a Protein Coding gene. Diseases associated with DPH3 include diphtheria.

UniProtKB/Swiss-Prot for DPH3 Gene

  • Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).

  • Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPH3 Gene

Genomics for DPH3 Gene

Genomic Location for DPH3 Gene

Start:
16,257,061 bp from pter
End:
16,264,989 bp from pter
Size:
7,929 bases
Orientation:
Minus strand

Genomic View for DPH3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPH3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPH3 Gene

Regulatory Elements for DPH3 Gene

Proteins for DPH3 Gene

  • Protein details for DPH3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FX2-DPH3_HUMAN
    Recommended name:
    DPH3 homolog
    Protein Accession:
    Q96FX2
    Secondary Accessions:

    Protein attributes for DPH3 Gene

    Size:
    82 amino acids
    Molecular mass:
    9240 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DPH3 Gene

    Alternative splice isoforms for DPH3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPH3 Gene

Proteomics data for DPH3 Gene at MOPED

Post-translational modifications for DPH3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DPH3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DPH3 Gene

Domains for DPH3 Gene

Protein Domains for DPH3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPH3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FX2

UniProtKB/Swiss-Prot:

DPH3_HUMAN
Family:
  • Belongs to the DPH3 family.:
    • Q96FX2
Similarity:
  • Contains 1 DPH-type zinc finger.:
    • Q96FX2
genes like me logo Genes that share domains with DPH3: view

No data available for Gene Families for DPH3 Gene

Function for DPH3 Gene

Molecular function for DPH3 Gene

UniProtKB/Swiss-Prot Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
UniProtKB/Swiss-Prot Function: Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5.

Gene Ontology (GO) - Molecular Function for DPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14980502
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DPH3: view
genes like me logo Genes that share phenotypes with DPH3: view

Animal Models for DPH3 Gene

MGI Knock Outs for DPH3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DPH3 Gene

Localization for DPH3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPH3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPH3 Gene COMPARTMENTS Subcellular localization image for DPH3 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for DPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14980502
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DPH3: view

Pathways for DPH3 Gene

SuperPathways for DPH3 Gene

No Data Available

UniProtKB/Swiss-Prot Q96FX2-DPH3_HUMAN

  • Pathway: Protein modification; peptidyl-diphthamide biosynthesis

Gene Ontology (GO) - Biological Process for DPH3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0050709 negative regulation of protein secretion IDA 14980502
GO:0051099 positive regulation of binding IDA 14980502
genes like me logo Genes that share ontologies with DPH3: view

No data available for Pathways by source for DPH3 Gene

Transcripts for DPH3 Gene

Unigene Clusters for DPH3 Gene

DPH3, KTI11 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPH3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
SP1: - -
SP2: - -
SP3: -
SP4:
SP5: - - -

Relevant External Links for DPH3 Gene

GeneLoc Exon Structure for
DPH3
ECgene alternative splicing isoforms for
DPH3

Expression for DPH3 Gene

mRNA expression in normal human tissues for DPH3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPH3 Gene

SOURCE GeneReport for Unigene cluster for DPH3 Gene Hs.388087

mRNA Expression by UniProt/SwissProt for DPH3 Gene

Q96FX2-DPH3_HUMAN
Tissue specificity: Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung.
genes like me logo Genes that share expressions with DPH3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DPH3 Gene

Orthologs for DPH3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPH3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPH3 35
  • 98.78 (n)
  • 98.78 (a)
DPH3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPH3 35
  • 90.24 (n)
  • 96.34 (a)
DPH3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPH3 35
  • 93.09 (n)
  • 95.12 (a)
DPH3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dph3 35
  • 91.06 (n)
  • 96.34 (a)
Dph3 16
Dph3 36
  • 96 (a)
OneToMany
Dph3b-ps 36
  • 82 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dph3 35
  • 92.28 (n)
  • 95.12 (a)
chicken
(Gallus gallus)
Aves DPH3 35
  • 70.46 (n)
  • 75.95 (a)
DPH3 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPH3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dph3 35
  • 74.8 (n)
  • 79.27 (a)
zebrafish
(Danio rerio)
Actinopterygii dph3 35
  • 69.7 (n)
  • 75.32 (a)
dph3 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011288 35
  • 61.04 (n)
  • 61.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14701 35
  • 66.67 (n)
  • 67.65 (a)
CG14701 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dph-3 35
  • 61.9 (n)
  • 67.14 (a)
dph-3 36
  • 60 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KTI11 36
  • 39 (a)
OneToOne
Species with no ortholog for DPH3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPH3 Gene

ENSEMBL:
Gene Tree for DPH3 (if available)
TreeFam:
Gene Tree for DPH3 (if available)

Paralogs for DPH3 Gene

Selected SIMAP similar genes for DPH3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DPH3 Gene

genes like me logo Genes that share paralogs with DPH3: view

No data available for Paralogs for DPH3 Gene

Variants for DPH3 Gene

Sequence variations from dbSNP and Humsavar for DPH3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs552 -- 16,260,452(-) TACTT(C/T)GGTAT utr-variant-3-prime
rs2855 -- 16,258,078(+) CCAAG(A/T)AAAAT utr-variant-3-prime
rs4199 -- 16,258,049(+) GCAGT(-/TATAA)AAAAT utr-variant-3-prime
rs10087 -- 16,259,641(+) TATAT(C/T)TCTTT utr-variant-3-prime
rs842250 -- 16,257,169(+) CCTTT(C/T)GGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DPH3 Gene

Variant ID Type Subtype PubMed ID
nsv876585 CNV Gain 21882294

Relevant External Links for DPH3 Gene

HapMap Linkage Disequilibrium report
DPH3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPH3 Gene

Disorders for DPH3 Gene

(1) MalaCards Diseases for DPH3 Gene

Search for DPH3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DPH3 Gene

genes like me logo Genes that share disorders with DPH3: view

No data available for UniProtKB/Swiss-Prot for DPH3 Gene

Publications for DPH3 Gene

  1. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. (PMID: 14980502) Sjoelinder M. … Ponstingl H. (Exp. Cell Res. 2004) 2 3 4 23
  2. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP- ribosylating toxins. (PMID: 14527407) Liu S. … Leppla S.H. (Mol. Cell 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PMID: 15485916) Liu S. … Leppla S.H. (Mol. Cell. Biol. 2004) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DPH3 Gene

Sources for DPH3 Gene

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