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DPH3 Gene

protein-coding   GIFtS: 45
GCID: GC03M016298

Diphthamide Biosynthesis 3

(Previous names: zinc finger, CSL-type containing 2, DPH3 homolog (KTI11,...)
(Previous symbol: ZCSL2)
  See DPH3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Diphthamide Biosynthesis 31 2     KTI11 Homolog A (S. Cerevisiae)1
ZCSL21 2 3 5     DELGIP2
DPH3 Homolog (KTI11, S. Cerevisiae)1 2     Deafness Locus Putative Guanine Nucleotide Exchange Factor Interacting
Protein 12
Zinc Finger, CSL-Type Containing 21 2     Del-GEF Interacting Protein2
DPH3A1 2     Diphtheria Toxin And Pseudomonas Exotoxin A Sensitivity Required Gene 12
DelGEF-Interacting Protein 12 3     DPH3 Homolog2
DESR12 3     DPH3, KTI11 Homolog2
CSL-Type Zinc Finger-Containing Protein 22 3     DPH3A, KTI11 Homolog A2
DELGIP12 5     Zinc Finger, CSL Domain Containing 22
KTI112 5     DelGIP13
DPH3, KTI11 Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 277171   Entrez Gene: 2853812   Ensembl: ENSG000001548137   OMIM: 6089595   UniProtKB: Q96FX23   

Export aliases for DPH3 gene to outside databases

Previous GC identifer: GC03M016277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPH3 Gene:
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded
protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to
diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and
Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same
isoform. (provided by RefSeq, Feb 2009)

GeneCards Summary for DPH3 Gene:
DPH3 (diphthamide biosynthesis 3) is a protein-coding gene. Diseases associated with DPH3 include diphtheria.

UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2
Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of
histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by
Pseudomonas exotoxin A (Eta) (By similarity)
Function: Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the
secretion process. Stimulates binding of GNEFR to SEC5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPH3 gene promoter:
         Pbx1a   HTF   AREB6   CREB   E2F   E2F-1   deltaCREB   FOXJ2 (long isoform)   FOXJ2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPH3 promoter sequence
   Search Chromatin IP Primers for DPH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

DPH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPH3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016298:  view genomic region     (about GC identifiers)

Start:
16,298,568 bp from pter      End:
16,306,496 bp from pter
Size:
7,929 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2 (See protein sequence)
Recommended Name: DPH3 homolog  
Size: 82 amino acids; 9240 Da
1 PDB 3D structure from and Proteopedia for DPH3:
2JR7 (3D)    
Alternative splicing: 2 isoforms:  Q96FX2-1   Q96FX2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DPH3: NX_Q96FX2

Explore proteomics data for DPH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DPH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001040899.1  NP_996662.1  

    ENSEMBL proteins: 
     ENSP00000419599   ENSP00000373285  

    DPH3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DPH3

     
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    Search eBioscience for ELISAs for DPH3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007872 Znf_DHP

    Graphical View of Domain Structure for InterPro Entry Q96FX2

    ProtoNet protein and cluster: Q96FX2

    UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2
    Similarity: Belongs to the DPH3 family
    Similarity: Contains 1 DPH-type zinc finger


    Find genes that share domains with DPH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPH3_HUMAN, Q96FX2
    Function: Essential for the first step in the synthesis of diphthamide, a post-translational modification of
    histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by
    Pseudomonas exotoxin A (Eta) (By similarity)
    Function: Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the
    secretion process. Stimulates binding of GNEFR to SEC5

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14980502
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with DPH3           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dph3):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with DPH3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dph3tm1Lepp for DPH3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPH3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DPH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPH3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPH3

    miRNA
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    Block miRNA regulation of human, mouse, rat DPH3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPH3 (see all 33):
    hsa-let-7d hsa-let-7a-2* hsa-miR-29b-1* hsa-let-7g hsa-miR-183* hsa-miR-124 hsa-miR-1184 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDPH3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPH3

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    GenScript: all cDNA clones in your preferred vector (see all 2): DPH3 (NM_206831)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPH3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPH3_HUMAN, Q96FX2: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with DPH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2
    Pathway: Protein modification; peptidyl-diphthamide biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPH3
    Interactions:

        Search GeneGlobe Interaction Network for DPH3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DPH3 (Q96FX21, 3 ENSP000004195994) via UniProtKB, MINT, STRING, and/or I2D (see all 31)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SERGEFQ9UGK81, 3, ENSP000002659654EBI-465363,EBI-465368 I2D: score=2 STRING: ENSP00000265965
    IKBKAPENSP000003637794STRING: ENSP00000363779
    DPH1ENSP000002630834STRING: ENSP00000263083
    DPH2ENSP000002551084STRING: ENSP00000255108
    ELP2ENSP000003509674STRING: ENSP00000350967
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine ISS--
    GO:0050709negative regulation of protein secretion IDA14980502
    GO:0051099positive regulation of binding IDA14980502

    Find genes that share ontologies with DPH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPH3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPH3 gene (2 alternative transcripts): 
    NM_001047434.2  NM_206831.2  

    Unigene Cluster for DPH3:

    DPH3, KTI11 homolog (S. cerevisiae)
    Hs.388087  [show with all ESTs]
    Unigene Representative Sequence: NM_206831
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488423(uc003cat.4 uc003cau.3 uc003cav.3) ENST00000383775
    ENST00000285082 ENST00000462982
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DPH3 (see all 33):
    hsa-let-7d hsa-let-7a-2* hsa-miR-29b-1* hsa-let-7g hsa-miR-183* hsa-miR-124 hsa-miR-1184 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidDPH3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DPH3 (NM_206831)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPH3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPH3
    Primer
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    OriGene qPCR primer pairs and template standards for DPH3
    OriGene qSTAR qPCR primer pairs in human, mouse for DPH3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPH3
      QuantiTect SYBR Green Assays in human, mouse, rat DPH3
      QuantiFast Probe-based Assays in human, mouse, rat DPH3

    Additional mRNA sequence: 

    AK022970.1 AK023203.1 AK092040.1 AK311618.1 BC010181.2 BC073931.1 BC094863.1 

    6 DOTS entries:

    DT.95262116  DT.100782472  DT.95257646  DT.92420590  DT.100734000  DT.100782473 

    Selected AceView cDNA sequences (see all 194):

    BF063630 F12397 BM549276 C04626 AI122599 BC010181 BQ213445 BM452855 
    AA831174 AA502392 AI097226 AW661665 AI249053 AA777638 N33756 BM504521 
    BM717191 AA865334 NM_206831 N80873 AA721309 BM834930 BM550423 H72496 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DPH3    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e
    SP1:                          -     -                                       
    SP2:                          -     -                                       
    SP3:                                -                                       
    SP4:                                                                        
    SP5:                          -     -     -                                 


    ECgene alternative splicing isoforms for DPH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DPH3 Expression
    About this image

    DPH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPH3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388087

    UniProtKB/Swiss-Prot: DPH3_HUMAN, Q96FX2
    Tissue specificity: Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DPH3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dph31 , 5 DPH3 homolog (KTI11, S. cerevisiae)5
    diphthamine biosynthesis 31
    91.06(n)1
    96.34(a)1
      14 (19.40 cM)5
    1056381  NM_001284346.11  NP_001271275.11 
     320805665 
    chicken
    (Gallus gallus)
    Aves DPH31 DPH3, KTI11 homolog (S. cerevisiae) 70.46(n)
    75.95(a)
      420643  XM_418742.4  XP_418742.3 
    lizard
    (Anolis carolinensis)
    Reptilia DPH36
    diphthamide biosynthesis 3
    78(a)
    1 ↔ 1
    6(35086952-35090896)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dph31 diphthamide biosynthesis 3 74.8(n)
    79.27(a)
      548911  NM_001016157.2  NP_001016157.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dph31 diphthamide biosynthesis 3 69.7(n)
    75.32(a)
      553692  NM_001159824.1  NP_001153296.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG147011 CG14701 66.67(n)
    67.65(a)
      41352  NM_141800.2  NP_650057.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dph-31 dph-3 61.9(n)
    67.14(a)
      186854  NM_001268490.1  NP_001255419.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KTI116
    Zn-ribbon protein that co-purifies with Dph1 and D...
    39(a)
    1 ↔ 1
    II(89978-90226) YBL071W-A


    ENSEMBL Gene Tree for DPH3 (if available)
    TreeFam Gene Tree for DPH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPH3 gene
    2 SIMAP similar genes for DPH3 using alignment to 1 protein entry:     DPH3_HUMAN:
    DPH3P1    DNAJC24

    Find genes that share paralogs with DPH3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DPH3
    PGOHUM00000242102


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPH3 (see all 148)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs759706511,2
    C,F--16298202(+) TTTGCA/TCTTCT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1409707571,2
    --16298208(+) CTTCTA/CATATT 2 -- ds50010--------
    rs778725931,2
    C,F--16298227(+) GAATAC/ATGTCA 2 -- ds50011Minor allele frequency- A:0.05NA 120
    rs1430630741,2
    --16298231(+) ACTGTC/GAATGT 2 -- ds50010--------
    rs1474866721,2
    C--16298250(+) GCTTGA/GATATG 2 -- ds50010--------
    rs1392366481,2
    --16298278(+) TCATAC/TTGAGG 2 -- ds50010--------
    rs1829149601,2
    --16298296(+) CCCAAA/CGTAAT 2 -- ds50010--------
    rs609790591,2
    C,F--16298313(+) GAAAGA/TTGGTG 2 -- ds50013Minor allele frequency- T:0.29WA 122
    rs1395254871,2
    C--16298332(+) GAGGT-/TATTTG 2 -- ds50010--------
    rs1872126511,2
    --16298377(+) GACATA/CTGGTG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DPH3 (16298568 - 16306496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DPH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876585CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPH3
    DNA2.0 Custom Variant and Variant Library Synthesis for DPH3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608959    OMIM disorders: --

    1 disease for DPH3:    
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    diphtheria

    1 disease from the University of Copenhagen DISEASES database for DPH3:
    Diphtheria

    Find genes that share disorders with DPH3           About GenesLikeMe


    Export disorders for DPH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPH3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with DPH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. (PubMed id 14980502)1, 2, 3, 9 Sjoelinder M.... Ponstingl H. (Exp. Cell Res. 2004)
    2. Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP- ribosylating toxins. (PubMed id 14527407)1, 2, 3 Liu S. and Leppla S.H. (Mol. Cell 2003)
    3. Solution structure of human DESR1, a CSL zinc-binding protein. (PubMed id 18214955)1, 2 Wu F.... Shi Y. (Proteins 2008)
    4. Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development. (PubMed id 16648478)1, 3 Liu S....Leppla S.H. (Mol. Cell. Biol. 2006)
    5. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PubMed id 15485916)1, 3 Liu S....Leppla S.H. (Mol. Cell. Biol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 285381 HGNC: 27717 AceView: ZCSL2 Ensembl:ENSG00000154813 euGenes: HUgn285381
    ECgene: DPH3 H-InvDB: DPH3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPH3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPH3 gene:
    Search GeneIP for patents involving DPH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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