Aliases for DPH2 Gene
External Ids for DPH2 Gene
Previous HGNC Symbols for DPH2 Gene
Previous GeneCards Identifiers for DPH2 Gene
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for DPH2 Gene
DPH2 (DPH2 Homolog) is a Protein Coding gene. Diseases associated with DPH2 include Diphtheria. Among its related pathways are Metabolism of proteins and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include 2-(3-amino-3-carboxypropyl)histidine synthase activity.
UniProtKB/Swiss-Prot for DPH2 Gene
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).