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DPH2 Gene

protein-coding   GIFtS: 53
GCID: GC01P044435

DPH2 Homolog (S. Cerevisiae)

(Previous names: diptheria toxin resistance protein required for diphthamide...)
(Previous symbol: DPH2L2)
  See DPH2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DPH2 Homolog (S. Cerevisiae)1 2     Diphthamide Biosynthesis Protein 22
DPH2L21 2 3 5     Diphthamide Biosynthesis-Like Protein 22
Diphthamide Biosynthesis Protein 2 Homolog-Like 22 3     Diptheria Toxin Resistance Protein Required For Diphthamide
Biosynthesis-Like 22
DPH2-Like 22 3     HsDph23
Diptheria Toxin Resistance Protein Required For Diphthamide
Biosynthesis-Like 2 (S. Cerevisiae)1
     DPH2 Homolog3
DPH2-Like 2 (S. Cerevisiae)1     

External Ids:    HGNC: 30041   Entrez Gene: 18022   Ensembl: ENSG000001327687   OMIM: 6034565   UniProtKB: Q9BQC33   

Export aliases for DPH2 gene to outside databases

Previous GC identifers: GC01P044105 GC01P044208 GC01P042552


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPH2 Gene:
This gene is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability
to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide
is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of
diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DPH2 Gene:
DPH2 (DPH2 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with DPH2 include spindle cell hemangioma.

UniProtKB/Swiss-Prot: DPH2_HUMAN, Q9BQC3
Function: Required for the first step in the synthesis of diphthamide, a post-translational modification of
histidine which occurs in translation elongation factor 2 (EEF2) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPH2 gene promoter:
         E2F-4   E2F-3a   E2F-5   Nkx2-5   E2F-2   GATA-2   c-Ets-1   FAC1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPH2 promoter sequence
   Search Chromatin IP Primers for DPH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34

DPH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPH2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P044435:  view genomic region     (about GC identifiers)

Start:
44,435,653 bp from pter      End:
44,439,043 bp from pter
Size:
3,391 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPH2_HUMAN, Q9BQC3 (See protein sequence)
Recommended Name: Diphthamide biosynthesis protein 2  
Size: 489 amino acids; 52083 Da
Subunit: Interacts with DPH1 (By similarity)
Secondary accessions: A8MVC9 B2RDE3 O60623
Alternative splicing: 2 isoforms:  Q9BQC3-1   Q9BQC3-2   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for DPH2: NX_Q9BQC3

Explore proteomics data for DPH2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys256
  • Modification sites at PhosphoSitePlus

  • See DPH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001034678.1  NP_001375.2  

    ENSEMBL proteins: 
     ENSP00000436330   ENSP00000255108   ENSP00000434977   ENSP00000431944   ENSP00000433273  
     ENSP00000379981   ENSP00000431831   ENSP00000432162   ENSP00000435561   ENSP00000413862  

    DPH2 Human Recombinant Protein Products:

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    Novus Biologicals DPH2 Proteins
    Novus Biologicals DPH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DPH2 

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for DPH2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010014 DHP2_eu
     IPR002728 DPH1/DPH2

    Graphical View of Domain Structure for InterPro Entry Q9BQC3

    ProtoNet protein and cluster: Q9BQC3

    1 Blocks protein domain: IPB002728 Diphthamide synthesis DPH2 protein

    UniProtKB/Swiss-Prot: DPH2_HUMAN, Q9BQC3
    Similarity: Belongs to the DPH1/DPH2 family. DPH2 subfamily


    Find genes that share domains with DPH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPH2_HUMAN, Q9BQC3
    Function: Required for the first step in the synthesis of diphthamide, a post-translational modification of
    histidine which occurs in translation elongation factor 2 (EEF2) (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DPH2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DPH2:
     Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dph2):
     mortality/aging 

    Find genes that share phenotypes with DPH2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dph2tm2(EUCOMM)Wtsi for DPH2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPH2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPH2

    miRNA
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    miRTarBase miRNAs that target DPH2:
    hsa-mir-615-3p (MIRT039820)

    Block miRNA regulation of human, mouse, rat DPH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPH2 (see all 12):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-539 hsa-miR-134 hsa-miR-323b-5p hsa-miR-29b-1* hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidDPH2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPH2

    Gene Editing
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPH2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DPH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: DPH2_HUMAN, Q9BQC3
    Pathway: Protein modification; peptidyl-diphthamide biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPH2
    Interactions:

        Search GeneGlobe Interaction Network for DPH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for DPH2 (Q9BQC33 ENSP000002551084) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204221O152133I2D: score=1 
    ENSG00000206284O152133I2D: score=1 
    ENSG00000226916O152133I2D: score=1 
    ENSG00000236222O152133I2D: score=1 
    WDR46O152133I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine IEA--

    Find genes that share ontologies with DPH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPH2

    1 Novoseek inferred chemical compound relationship for DPH2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diphthamide 97.7 8 9782084 (3), 11054663 (2), 8603384 (1)



    Find genes that share compounds with DPH2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPH2 gene (3 alternative transcripts): 
    NM_001039589.1  NM_001384.4  NM_201399.1  

    Unigene Cluster for DPH2:

    DPH2 homolog (S. cerevisiae)
    Hs.632398  [show with all ESTs]
    Unigene Representative Sequence: NM_001384
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471934 ENST00000476260 ENST00000255108(uc001ckz.3 uc001cla.3 uc010okk.2)
    ENST00000524776 ENST00000530988 ENST00000495421(uc001clb.3) ENST00000527567
    ENST00000492306 ENST00000490861 ENST00000396758 ENST00000477294 ENST00000529729
    ENST00000532140 ENST00000534786 ENST00000534655 ENST00000459879 ENST00000527319
    ENST00000412950
    miRNA
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    Block miRNA regulation of human, mouse, rat DPH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPH2 (see all 12):
    hsa-miR-4324 hsa-miR-125a-5p hsa-miR-4251 hsa-miR-539 hsa-miR-134 hsa-miR-323b-5p hsa-miR-29b-1* hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidDPH2 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DPH2 (NM_001384)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPH2
    Primer
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    OriGene qPCR primer pairs and template standards for DPH2
    OriGene qSTAR qPCR primer pairs in human, mouse for DPH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPH2
      QuantiTect SYBR Green Assays in human, mouse, rat DPH2
      QuantiFast Probe-based Assays in human, mouse, rat DPH2

    Additional mRNA sequence: 

    AF053003.1 AK091303.1 AK297933.1 AK315506.1 BC001389.2 BC003181.1 BC016956.1 BT007431.1 

    15 DOTS entries:

    DT.454425  DT.100826745  DT.92458071  DT.121402620  DT.121402608  DT.97802614  DT.100662512  DT.100826738 
    DT.97862563  DT.92458043  DT.100826740  DT.100826747  DT.121402606  DT.95211037  DT.95211069 

    Selected AceView cDNA sequences (see all 295):

    BQ646702 CB158063 CR600358 BM458325 BU188624 CA432584 CR599890 BU182554 
    BE280889 AI480373 BE293940 BM823751 BQ212520 BM763739 BM763692 BM742228 
    BM742909 BQ072050 CR593501 BE276780 CA488653 BM772798 BE382336 BC016956 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DPH2 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a ·
    SP1:                                            -     -     -     -     -                                   -                                                   
    SP2:                    -     -                 -     -     -     -     -                                   -                                                   
    SP3:                                            -     -     -     -     -                                   -     -     -     -     -     -     -               
    SP4:                          -                 -     -     -     -     -                                   -                                                   
    SP5:                                            -     -     -     -     -                                   -     -     -     -                                 

    ExUns: 8b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for DPH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAAAGTT
    DPH2 Expression
    About this image

    DPH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632398

    UniProtKB/Swiss-Prot: DPH2_HUMAN, Q9BQC3
    Tissue specificity: Strongly expressed in skeletal muscle. Moderately expressed in heart, small intestine, liver,
    pancreas, testis and colon. Weakly expressed in brain, placenta, kidney, spleen, thymus, prostate, ovary and
    lymphocytes

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    QuantiFast Probe-based Assays in human, mouse, rat DPH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPH2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dph21 , 5 DPH2 homolog (S. cerevisiae)1, 5 81.76(n)1
    83.81(a)1
      4 (53.74 cM)5
    677281  NM_026344.31  NP_080620.11 
     1178886435 
    chicken
    (Gallus gallus)
    Aves DPH21 DPH2 homolog (S. cerevisiae) 58.46(n)
    51.2(a)
      424574  NM_001006538.1  NP_001006538.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPH26
    DPH2 homolog (S. cerevisiae)
    47(a)
    1 ↔ 1
    4(108860037-108864844)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dph21 DPH2 homolog 54.31(n)
    47.81(a)
      100135719  XM_002931582.2  XP_002931628.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dph21 DPH2 homolog (S. cerevisiae) 49.65(n)
    41.98(a)
      562538  NM_001089397.1  NP_001082866.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72651 CG7265 47.63(n)
    38.46(a)
      41802  NM_142145.3  NP_650402.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dph-26
    Protein DPH-2, isoform a
    30(a)
    1 ↔ 1
    II(10702233-10714299) WBGene00007488
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DPH2(YKL191W)4
    DPH21
    Protein required, along with Dph1p, Kti11p, Jjj3p, more4
    DPH21
    41.01(n)1
    28.19(a)1
      11(81035-82639)4
    8536431, 4  NP_012730.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G596301 AT3G59630 41.91(n)
    32.28(a)
      825132  NM_115825.4  NP_191522.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g02656001 Os11g0265600 45.16(n)
    34.32(a)
      4350247  NM_001074193.2  NP_001067661.2 


    ENSEMBL Gene Tree for DPH2 (if available)
    TreeFam Gene Tree for DPH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPH2 (see all 153)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs577986281,2
    --42549536(+) AGAGTA/GTGGTT 2 -- us2k10--------
    rs1816704991,2
    --42549691(+) TTGAGC/TGTGTG 2 -- us2k10--------
    rs601513861,2
    F--42549831(+) AGTGTT/ACTGGG 2 -- us2k11Minor allele frequency- A:0.05WA 118
    rs359532811,2
    C,F--42549874(+) GGTGTG/ATCTTT 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1896953341,2
    --42549896(+) TGTCTA/GAATGT 2 -- us2k10--------
    rs37911191,2
    C,F--42550057(+) GTTAGC/GGGTGT 2 -- us2k116Minor allele frequency- G:0.50EA NA WA CSA 2003
    rs1808794181,2
    C--42550232(+) GAGCTC/GTGCAG 2 -- us2k10--------
    rs1410578251,2
    --44434201(+) GGGACA/CGCTCC 2 -- us2k10--------
    rs1502406371,2
    --44434203(+) GACAGC/TTCCTG 2 -- us2k10--------
    rs127584731,2
    F,H--44434233(+) CCTTAG/ACAGTG 2 -- us2k14Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for DPH2 (44435653 - 44439043 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DPH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv870606CNV Loss21882294
    dgv217n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPH2
    DNA2.0 Custom Variant and Variant Library Synthesis for DPH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603456    OMIM disorders: --

    1 disease for DPH2:    
    About MalaCards
    spindle cell hemangioma

    2 diseases from the University of Copenhagen DISEASES database for DPH2:
    Diphtheria     Spindle cell hemangioma

    Find genes that share disorders with DPH2           About GenesLikeMe

    1 Novoseek inferred disease relationship for DPH2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 18 2 9782084 (1)

    Genetic Association Database (GAD): DPH2
    Human Genome Epidemiology (HuGE) Navigator: DPH2 (1 document)

    Export disorders for DPH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPH2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with DPH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2. (PubMed id 9782084)1, 2, 3, 9 Schultz D.C.... Godwin A.K. (Genomics 1998)
    2. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PubMed id 15485916)1, 3, 9 Liu S....Leppla S.H. (Mol. Cell. Biol. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    6. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1802 HGNC: 3004 AceView: DPH2L2 Ensembl:ENSG00000132768 euGenes: HUgn1802
    ECgene: DPH2 H-InvDB: DPH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPH2 gene:
    Search GeneIP for patents involving DPH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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