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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPH1 Gene

protein-coding   GIFtS: 53
GCID: GC17P001933

DPH1 homolog (S. cerevisiae)

(Previous names: diptheria toxin resistance protein required for diphthamide...)
(Previous symbols: DPH2L, DPH2L1)
 Explore 11 diseases affiliated with
DPH1 via our new
 Human Malady Compendium 
Biological research products
for DPH1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DPH1 Homolog (S. Cerevisiae)1 2     DPH-Like 1 (S. Cerevisiae)1
DPH2L11 2 3 5     Candidate Tumor Suppressor In Ovarian Cancer 12
OVCA11 2 3 5     Diphthamide Biosynthesis Protein 12
DPH2L1 2 3     Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis
(Saccharomyces)-Like 12
Diphthamide Biosynthesis Protein 2 Homolog-Like 12 3     Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis-Like 12
Ovarian Cancer-Associated Gene 1 Protein2 3     Ovarian Tumor Suppressor Candidate 12
DPH-Like 12 3     HsDph13
DPH2-Like 12 3     Diphthamide Biosynthesis Protein 2-Like3
Diptheria Toxin Resistance Protein Required For Diphthamide Biosynthesis-Like 1
(S. Cerevisiae)1
     DPH1 Homolog3

External Ids:    HGNC: 30031   Entrez Gene: 18012   Ensembl: ENSG000001089637   OMIM: 6035275   UniProtKB: Q9BZG83   

Export aliases for DPH1 gene to outside databases

Previous GC identifer: GC17P001881


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPH1:
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM
130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation
and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in
synthesis of diphthamide in EEF2 (Liu et al., 2004 (PubMed 15485916)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: DPH1_HUMAN, Q9BZG8
Function: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine
which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth
rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role
in embryonic growth, organogenesis and postnatal survival (By similarity)

Gene Wiki entry for DPH1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPH1 gene promoter:
         Max1   NF-1   NCX/Ncx   SREBP-1c   LUN-1   GATA-2   SREBP-1b   SREBP-1a   Chx10   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DPH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

DPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPH1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P001933:  view genomic region     (about GC identifiers)

Start:
1,933,404 bp from pter      End:
1,946,725 bp from pter
Size:
13,322 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DPH1_HUMAN, Q9BZG8 (See protein sequence)
Recommended Name: Diphthamide biosynthesis protein 1  
Size: 443 amino acids; 48805 Da
Subunit: Interacts with DPH2 (By similarity). Interacts with RBM8A
Subcellular location: Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization
Caution: It is uncertain whether Met-1 or Met-6 is the initiator
Secondary accessions: D3DTI3 Q16439 Q4VBA2 Q9BTW7 Q9UCY0
Alternative splicing: 3 isoforms:  Q9BZG8-1   Q9BZG8-2   Q9BZG8-3   

Explore the universe of human proteins at neXtProt for DPH1: NX_Q9BZG8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BZG8

  • DPH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001374.3  
    ENSEMBL proteins: 
     ENSP00000263083   ENSP00000460431   ENSP00000458838   ENSP00000459308   ENSP00000458726  
     ENSP00000467936   ENSP00000460813  

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    Uscn Proteins for DPH1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    DPH1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DPH1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016435 eu_DPH1/arc_DPH2
     IPR002728 DPH1/DPH2

    Graphical View of Domain Structure for InterPro Entry Q9BZG8

    ProtoNet protein and cluster: Q9BZG8

    1 Blocks protein family: IPB002728 Diphthamide synthesis DPH2 protein

    UniProtKB/Swiss-Prot: DPH1_HUMAN, Q9BZG8
    Similarity: Belongs to the DPH1/DPH2 family. DPH1 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DPH1_HUMAN, Q9BZG8
    Function: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine
    which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth
    rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role
    in embryonic growth, organogenesis and postnatal survival (By similarity)

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----


    DPH1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DPH1:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for DPH1: Dph1tm2Bhr Dph1tm1Bhr
         15/16 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dph1) (see all 16):
     cellular  craniofacial  digestive/alimentary  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  limbs/digits/tail  liver/biliary system  mortality/aging 
     nervous system  pigmentation  respiratory system  skeleton  tumorigenesis 

    DPH1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/51 Interacting proteins for DPH1 (Q9BZG83 ENSP000002630834) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    EEF2P136393, ENSP000003079404I2D: score=6 STRING: ENSP00000307940
    HSPA5P110213, ENSP000003241734I2D: score=4 STRING: ENSP00000324173
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS8603384
    GO:0008283cell proliferation IEA--
    GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine IEA--


    DPH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DPH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPH1
    3 Novoseek chemical compound relationships for DPH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diphthamide 96.9 8 15485916 (2), 11054663 (1), 8603384 (1), 8564979 (1) (see all 5)
    n-(4-hydroxyphenyl)retinamide 74.3 6 11979432 (2), 11054663 (1)
    retinoic acid 33.3 6 11979432 (2), 11054663 (1)

    Search CenterWatch for drugs/clinical trials and news about DPH1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPH1 gene: 
    NM_001383.3  

    Unigene Cluster for DPH1:

    DPH1 homolog (S. cerevisiae)
    Hs.513856  [show with all ESTs]
    Unigene Representative Sequence: AK090530
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263083(uc002fts.3 uc002ftt.3 uc010cjx.3 uc010vqs.2)
    ENST00000575667 ENST00000571418 ENST00000572819 ENST00000576684 ENST00000576129
    ENST00000570477 ENST00000570833 ENST00000576891 ENST00000572214 ENST00000570867(uc002ftv.3)
    ENST00000575998 ENST00000571710(uc002ftw.3) ENST00000572684 ENST00000572248
    ENST00000575162

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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPH1

    Additional cDNA sequence: 

    AF073528.1 AF321875.1 AF321876.1 AK090530.1 AK297947.1 AK314015.1 BC003099.1 BC040696.2 
    BC041170.1 BC096086.1 BC096087.1 BC096088.1 BC096089.1 BT019878.1 S81752.1 U34880.1 

    17 DOTS entries:

    DT.453769  DT.91765825  DT.95158956  DT.95349153  DT.95158951  DT.100807851  DT.120980892  DT.97836300 
    DT.100738197  DT.100807846  DT.91765824  DT.120980964  DT.421591  DT.100807850  DT.91765823  DT.120980989 
    DT.95158962 

    24/384 AceView cDNA sequences (see all 384):

    AW874226 BM551324 AA595088 BM699273 CB132890 BC041170 H83609 CA430374 
    BM558769 CR600107 BM424280 CD674155 AI357934 BM809228 CA868138 BC003099 
    AI369646 BQ941225 AI753316 AI193095 AA632255 BI117197 AI131155 NM_080822 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DPH1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^
    SP1:                                            -     -                       -     -     -     -                       -           -           -               
    SP2:                                      -     -     -                       -     -     -     -                       -           -           -               
    SP3:                                            -     -                                                                                                         
    SP4:                                                                          -     -     -     -                                   -           -               
    SP5:                                                                                                                    -           -                           

    ExUns: 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:        -                                 
    SP2:        -                                 
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for DPH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGACTGCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DPH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPH1

    SOURCE GeneReport for Unigene cluster: Hs.513856

    UniProtKB/Swiss-Prot: DPH1_HUMAN, Q9BZG8
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen,
    thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian
    tumors

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DPH1 gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DPH11 DPH1 homolog (S. cerevisiae) 73.65(n)
    73.82(a)
      417564  NM_001030716.1  NP_001025887.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPH16
    --
    68(a)
    1 ↔ 1
    GL344600.1(57-8703)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.106302 Xenopus laevis transcribed sequence with weak similarity more 79.01(n)    48036208 
    zebrafish
    (Danio rerio)
    Actinopterygii dph11 DPH1 homolog (S. cerevisiae) 69.55(n)
    73.4(a)
      550559  NM_001017861.1  NP_001017861.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG116521 CG11652 60.22(n)
    61.06(a)
      39317  NM_140239.3  NP_648496.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dph-11 Protein DPH-1 54.33(n)
    54.86(a)
      175475  NM_065349.3  NP_497750.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DPH1(YIL103W)4
    DPH11
    Protein required, along with Dph2p, Kti11p, Jjj3p, more4
    Dph1p1
    53.46(n)1
    53.28(a)1
      9(171751-173028)4
    8547031, 4  NP_012163.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G620301 diphthamide synthesis DPH2 family protein 54.84(n)
    54.55(a)
      836323  NM_125596.3  NP_201009.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g08156001 hypothetical protein 55.85(n)
    52.01(a)
      4331131  NM_001055039.1  NP_001048504.1 


    ENSEMBL Gene Tree for DPH1 (if available)
    TreeFam Gene Tree for DPH1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/258 NCBI SNPs in DPH1 are shown (see all 258    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766625641,2
    --1931462(+) TTCTTG/TTCAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs80787121,2
    C,F,A,--1931576(+) CACGGA/GGTCTT 1 -- us2k110Minor allele frequency- G:0.28NA WA CSA EA 371
    rs99113681,2
    C,F,A,H,--1931655(+) GCCAGG/AGCAGC 1 -- us2k114Minor allele frequency- A:0.30NS EA NA WA 786
    rs1441103991,2
    --1931681(+) GGTGCA/GGGGCA 1 -- us2k10--------
    rs72077491,2
    C,F,A,H,--1931702(+) AGGGAT/GGGGAC 1 -- us2k121Minor allele frequency- G:0.27NS EA NA WA CSA 2346
    rs1911930471,2
    --1931743(+) GAGGGA/CAAGGT 1 -- us2k10--------
    rs1808738031,2
    --1931763(+) TATGGC/TGCCTG 1 -- us2k10--------
    rs72227161,2
    C,F,A,--1931862(+) GCAGCA/GGTGTC 1 -- us2k19Minor allele frequency- G:0.28NA WA CSA EA 370
    rs72227281,2
    C,F,A,--1931893(+) CTCCCA/GGAATT 1 -- us2k19Minor allele frequency- G:0.27NA WA CSA EA 370
    rs1851332551,2
    --1931959(+) CCGGAC/TGCTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPH1 (1933404 - 1946725 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for DPH1
         2 CNVs: 67105 7142

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DPH1 for disorders           About GeneDecksing

    OMIM gene information: 603527    OMIM disorders: --

    11 diseases for DPH1:    About MalaCards
    ovarian cancer    diphtheria    miller-dieker syndrome    esophageal squamous cell carcinoma
    squamous cell carcinoma    sotos syndrome    lissencephaly    esophagitis
    breast cancer    carcinoma    malaria

    1 disease from the University of Copenhagen DISEASES database for DPH1:
    Diphtheria

    4 Novoseek disease relationships for DPH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allelic loss 73.6 1 11979432 (1)
    ovarian cancer 50.6 2 11527402 (1), 16386221 (1)
    tumors 31.6 11 11979432 (2), 11013075 (2), 15485916 (1), 9782084 (1) (see all 7)
    cancer 8.67 3 11054663 (1), 11527402 (1), 16386221 (1)


    Export disorders for DPH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPH1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with DPH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3. (PubMed id 8603384)1, 2, 3, 9 Phillips N.J.... Deaven L.L. (1996)
    2. Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. (PubMed id 15485916)1, 3, 9 Liu S....Leppla S.H. (2004)
    3. Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor. (PubMed id 11013075)1, 2, 9 Salicioni A.M....Godwin A.K. (2000)
    4. Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells. (PubMed id 10519411)1, 2 Bruening W....Godwin A.K. (1999)
    5. Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (PubMed id 8616839)1, 2 Schultz D.C....Godwin A.K. (1996)
    6. Cloning, structure, and expression of the mouse Ovca1 gene. (PubMed id 11527402)1, 9 Chen C.M. and Behringer R.R. (2001)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. OVCA1 inhibits the proliferation of epithelial ovaria n cancer cells by decreasing cyclin D1 and increasing p16. (PubMed id 21487939)1 Kong F....Zhao C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1801 HGNC: 3003 AceView: DPH2L1 Ensembl:ENSG00000108963 euGenes: HUgn1801
    ECgene: DPH1 H-InvDB: DPH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPH1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DPH1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPH1 gene:
    Search GeneIP for patents involving DPH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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