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DPF3 Gene

protein-coding   GIFtS: 50
GCID: GC14M073086

D4, Zinc And Double PHD Fingers, Family 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
D4, Zinc And Double PHD Fingers, Family 31 2
CERD42 3 5
Zinc Finger Protein Cer-D42 3
BAF45C2 3
BRG1-Associated Factor 45C2 3
Zinc Finger Protein DPF32

External Ids:    HGNC: 174271   Entrez Gene: 81102   Ensembl: ENSG000002056837   OMIM: 6016725   UniProtKB: Q927843   

Export aliases for DPF3 gene to outside databases

Previous GC identifers: GC14M066871 GC14M071065 GC14M072145 GC14M053303


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPF3 Gene:
This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds
acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for DPF3 Gene:
DPF3 (D4, zinc and double PHD fingers, family 3) is a protein-coding gene. Diseases associated with DPF3 include tooth agenesis, and cleft lip. An important paralog of this gene is PHF10.

UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784
Function: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a
switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell
cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells
to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural
progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and
PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in
neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of
the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of
genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein
complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration
of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac,
H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and
methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle
development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPF3 gene promoter:
         ATF-2   Cdc5   HNF-1A   E2F   E2F-1   FOXO4   HNF-1   Cart-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPF3 promoter sequence
   Search Chromatin IP Primers for DPF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

DPF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPF3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M073086:  view genomic region     (about GC identifiers)

Start:
73,086,004 bp from pter      End:
73,360,809 bp from pter
Size:
274,806 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784 (See protein sequence)
Recommended Name: Zinc finger protein DPF3  
Size: 378 amino acids; 43084 Da
Subunit: Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,
SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170,
SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF
complex also contains DPF3. Interacts with acetylated histones H3 and H4. Component of neuron-specific chromatin
remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A,
SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57,
SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity)
4 PDB 3D structures from and Proteopedia for DPF3:
2KWJ (3D)        2KWK (3D)        2KWN (3D)        2KWO (3D)    
Secondary accessions: A8MSI3 Q32UJ0 Q6P9E6 Q6ZT41 Q9H7Y5
Alternative splicing: 4 isoforms:  Q92784-1   Q92784-2   Q92784-3   Q92784-4   (Ref.2 (BAB14838) sequence differs from that shown due to a frameshift in position 187)

Explore the universe of human proteins at neXtProt for DPF3: NX_Q92784

Explore proteomics data for DPF3 at MOPED


See DPF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001267471.1  NP_001267472.1  NP_001267473.1  NP_036206.3  

ENSEMBL proteins: 
 ENSP00000450518   ENSP00000381791   ENSP00000370614   ENSP00000444662   ENSP00000441640  

DPF3 Human Recombinant Protein Products:

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Cloud-Clone Corp. CLIAs for DPF3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PHF: Zinc fingers, PHD-type

Selected InterPro protein domains (see all 8):
 IPR015880 Znf_C2H2-like
 IPR001841 Znf_RING
 IPR001965 Znf_PHD
 IPR013083 Znf_RING/FYVE/PHD
 IPR025750 Requiem/DPF_N_dom

Graphical View of Domain Structure for InterPro Entry Q92784

ProtoNet protein and cluster: Q92784

UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784
Domain: The PHD-type zinc fingers mediate the binding to acetylated histones
Similarity: Belongs to the requiem/DPF family
Similarity: Contains 1 C2H2-type zinc finger
Similarity: Contains 2 PHD-type zinc fingers


DPF3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DPF3_HUMAN, Q92784
Function: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a
switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell
cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells
to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural
progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and
PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in
neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of
the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of
genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein
complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration
of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac,
H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and
methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle
development

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008270zinc ion binding NAS8812431
GO:0046872metal ion binding ----
     
DPF3 for ontologies           About GeneDecksing


Animal Models:
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miRNA
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miRTarBase miRNAs that target DPF3:
hsa-mir-26b-5p (MIRT030041)

Block miRNA regulation of human, mouse, rat DPF3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DPF3 (see all 28):
hsa-miR-199b-3p hsa-miR-106a hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-218 hsa-miR-515-5p hsa-miR-9 hsa-miR-93
SwitchGear 3'UTR luciferase reporter plasmidDPF3 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat DPF3

Gene Editing
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GenScript: all cDNA clones in your preferred vector: DPF3 (NM_012074)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF3

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DPF3_HUMAN, Q92784: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus ----
GO:0071565nBAF complex ISS--

DPF3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPF3
Interactions:

    Search GeneGlobe Interaction Network for DPF3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DPF3 (Q927843 ENSP000003817914) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
InteractantInteraction Details
GeneCardExternal ID(s)
ESRRAP114743, ENSP000000004424I2D: score=1 STRING: ENSP00000000442
CTSBP078583I2D: score=4 
IRF2BP2Q7Z5L93I2D: score=3 
ACTL6AENSP000003975524STRING: ENSP00000397552
ACTL6BENSP000001603824STRING: ENSP00000160382
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--
GO:0007399nervous system development IEA--
GO:0008150biological_process ND--
GO:0016568chromatin modification IEA--

DPF3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DPF3



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DPF3 gene (4 alternative transcripts): 
NM_001280542.1  NM_001280543.1  NM_001280544.1  NM_012074.4  

Unigene Cluster for DPF3:

D4, zinc and double PHD fingers, family 3
Hs.162868  [show with all ESTs]
Unigene Representative Sequence: AK024141
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000556509(uc001xnc.2) ENST00000557704(uc001xnd.1) ENST00000366353
ENST00000381216(uc001xnf.2) ENST00000546183 ENST00000556891 ENST00000556997
ENST00000556238 ENST00000554594 ENST00000555781 ENST00000553608 ENST00000556902
ENST00000555469 ENST00000541685(uc010ari.1 uc010ttq.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DPF3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate DPF3 (see all 28):
hsa-miR-199b-3p hsa-miR-106a hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-218 hsa-miR-515-5p hsa-miR-9 hsa-miR-93
SwitchGear 3'UTR luciferase reporter plasmidDPF3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DPF3
Predesigned siRNA for gene silencing in human, mouse, rat DPF3
Clone
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OriGene clones in human, mouse for DPF3 (see all 7)
OriGene ORF clones in mouse, rat for DPF3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: DPF3 (NM_012074)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF3
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for DPF3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPF3
  QuantiTect SYBR Green Assays in human, mouse, rat DPF3
  QuantiFast Probe-based Assays in human, mouse, rat DPF3

Additional mRNA sequence: 

AK024141.1 AK123045.1 AK124615.1 AK126074.1 AK294425.1 AY803021.1 BC021812.1 

10 DOTS entries:

DT.101982384  DT.97836363  DT.410381  DT.427144  DT.406091  DT.91653870  DT.100738740  DT.104059 
DT.101982382  DT.443455 

Selected AceView cDNA sequences (see all 101):

AW236736 AW771496 BM674729 AW978703 BE463687 AI479192 AI628765 AA909451 
AI361027 F12896 H72344 BU727351 H49646 AK123045 AA714655 BM717362 
AK126074 BF515253 F05876 BM805160 AI125562 AA308399 F02123 Z38944 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DPF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
DPF3 Expression
About this image


DPF3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Mature Rod Cells Outer Nuclear Layer
         Retina
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 NULL (Uncategorized)
         CD31, CD144 positive cells
 
 Neurons
         Mature Rod Cells Outer Nuclear Layer
 
 Neural Tube (Nervous System)
         Telencephalon
DPF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DPF3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.162868
    Custom PCR Arrays for DPF3
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for DPF3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPF3
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QuantiFast Probe-based Assays in human, mouse, rat DPF3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DPF3 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dpf31 , 5 D4, zinc and double PHD fingers, family 31, 5 92.15(n)1
99.74(a)1
  12 (38.47 cM)5
701271  NM_001267625.11  NP_001254554.11 
 832137455 
chicken
(Gallus gallus)
Aves DPF31 D4, zinc and double PHD fingers, family 3 82.72(n)
91.27(a)
  395351  NM_204639.1  NP_989970.1 
lizard
(Anolis carolinensis)
Reptilia DPF36
D4, zinc and double PHD fingers, family 3
70(a)
1 ↔ 1
1(38547377-38787451)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.196392 Transcribed sequence with moderate similarity to protein more 75.97(n)    AL887191.2 
zebrafish
(Danio rerio)
Actinopterygii dpf31 D4, zinc and double PHD fingers, family 3 71.07(n)
73.58(a)
  562738  NM_001111169.1  NP_001104639.1 
fruit fly
(Drosophila melanogaster)
Insecta d46
tth6
toothrin
22(a)
18(a)
many ↔ many
many ↔ many
2R(1147484-1183475)
X(13507226-13510436)
worm
(Caenorhabditis elegans)
Secernentea dpff-11 dpff-1 46.1(n)
35.96(a)
  175832  NM_065880.5  NP_498281.2 


ENSEMBL Gene Tree for DPF3 (if available)
TreeFam Gene Tree for DPF3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DPF3 gene
PHF102  DPF22  DPF12  
2 SIMAP similar genes for DPF3 using alignment to 3 protein entries:     DPF3_HUMAN (see all proteins):
DPF2    DPF1

DPF3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DPF3 (see all 4836)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1889981571,2
--73136368(+) CCATTC/TTCTCT 1 -- ds50010--------
rs732981581,2
C,F--73136453(+) ACCTAT/CGCCAG 1 -- ds50014Minor allele frequency- C:0.25WA CSA EA 242
rs2004209301,2
C--73136573(+) AAGCT-/GGGGGG 1 -- ds50010--------
rs793501961,2
F--73136617(+) GATATG/AATGGT 1 -- ds50011Minor allele frequency- A:0.06WA 118
rs1508578001,2
--73136676(+) GACCTC/TGCAGC 1 -- ut310--------
rs2011551741,2
C--73136733(+) CCCCA-/GGGGCC 1 -- ut310--------
rs1146909391,2
C,F--73136887(+) AAGGGG/AAGGGG 1 -- ut311Minor allele frequency- A:0.06WA 118
rs38148671,2
C,F,H--73137025(-) CACTTT/CCCTCC 1 -- ut31 trp319Minor allele frequency- C:0.17EA NS NA WA CSA 3416
rs1440311811,2
--73137066(+) TCTACC/TGACGG 1 -- ut310--------
rs1923671621,2
--73137101(+) TGGTCA/GGGGCC 1 -- ut310--------

HapMap Linkage Disequilibrium report for DPF3 (73086004 - 73336004 bp, first 250kb of DPF3)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for DPF3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2675309CNV Deletion23128226
esv2748861CNV Deletion23290073
nsv85673CNV Loss16902084
nsv520843CNV Loss19592680
esv32878CNV Loss17666407
esv29330CNV Gain19812545
nsv517683CNV Gain19592680
esv260025OTHER Complex20981092

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601672    OMIM disorders: --

5 diseases for DPF3:    
About MalaCards
tooth agenesis    cleft lip    neuronitis    breast cancer
endotheliitis

1 disease from the University of Copenhagen DISEASES database for DPF3:
Tooth agenesis

DPF3 for disorders           About GeneDecksing

Genetic Association Database (GAD): DPF3
Human Genome Epidemiology (HuGE) Navigator: DPF3 (2 documents)

Export disorders for DPF3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DPF3 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with DPF3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The d4 gene family in the human genome. (PubMed id 8812431)1, 2, 3 Chestkov A.V.... Buchman V.L. (Genomics 1996)
  2. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PubMed id 11845289)1, 3, 9 Ninkina N.N....Buchman V.L. (Mamm. Genome 2001)
  3. Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. (PubMed id 20613843)1, 2 Zeng L.... Zhou M.M. (Nature 2010)
  4. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. (PubMed id 18765789)1, 2 Lange M.... Sperling S. (Genes Dev. 2008)
  5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  7. Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-I_B RelA/p50 heterodimer. (PubMed id 22334708)1 Ishizaka A....Iba H. (J. Biol. Chem. 2012)
  8. Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1. (PubMed id 20400511)1 Matsuyama R....Kato S. (J. Biol. Chem. 2010)
  9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  10. Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases. (PubMed id 16109180)1 Hoyal C.R....Braun A. (J Carcinog 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8110 HGNC: 17427 AceView: DPF3 Ensembl:ENSG00000205683 euGenes: HUgn8110
ECgene: DPF3 H-InvDB: DPF3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DPF3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DPF3 gene:
Search GeneIP for patents involving DPF3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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