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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPF3 Gene

protein-coding   GIFtS: 50
GCID: GC14M073086

D4, Zinc And Double PHD Fingers, Family 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
D4, Zinc And Double PHD Fingers, Family 31 2
CERD42 3 5
Zinc Finger Protein Cer-D42 3
BAF45C2 3
BRG1-Associated Factor 45C2 3
Zinc Finger Protein DPF32

External Ids:    HGNC: 174271   Entrez Gene: 81102   Ensembl: ENSG000002056837   OMIM: 6016725   UniProtKB: Q927843   

Export aliases for DPF3 gene to outside databases

Previous GC identifers: GC14M066871 GC14M071065 GC14M072145 GC14M053303


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DPF3 Gene:
This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds
acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in
multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for DPF3 Gene: 
DPF3 (D4, zinc and double PHD fingers, family 3) is a protein-coding gene. Diseases associated with DPF3 include tooth agenesis, and cleft lip. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is PHF10.

UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784
Function: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a
switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell
cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells
to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural
progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and
PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in
neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of
the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of
genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein
complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration
of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac,
H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and
methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle
development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPF3 gene promoter:
         ATF-2   Cdc5   HNF-1A   E2F   E2F-1   FOXO4   HNF-1   Cart-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

DPF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPF3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M073086:  view genomic region     (about GC identifiers)

Start:
73,086,004 bp from pter      End:
73,360,809 bp from pter
Size:
274,806 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784 (See protein sequence)
Recommended Name: Zinc finger protein DPF3  
Size: 378 amino acids; 43084 Da
Subunit: Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,
SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170,
SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF
complex also contains DPF3. Interacts with acetylated histones H3 and H4. Component of neuron-specific chromatin
remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A,
SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57,
SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity)
Subcellular location: Nucleus (Probable)
4 PDB 3D structures from and Proteopedia for DPF3:
2KWJ (3D)        2KWK (3D)        2KWN (3D)        2KWO (3D)    
Secondary accessions: A8MSI3 Q32UJ0 Q6P9E6 Q6ZT41 Q9H7Y5
Alternative splicing: 4 isoforms:  Q92784-1   Q92784-2   Q92784-3   Q92784-4   (Ref.2 (BAB14838) sequence differs from that shown due to a frameshift in position 187)

Explore the universe of human proteins at neXtProt for DPF3: NX_Q92784

Explore proteomics data for DPF3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92784

  • DPF3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DPF3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001267471.1  NP_001267472.1  NP_001267473.1  NP_036206.3  

    ENSEMBL proteins: 
     ENSP00000450518   ENSP00000381791   ENSP00000370614   ENSP00000444662   ENSP00000441640  

    Human Recombinant Protein Products for DPF3: 
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    Cloud-Clone Corp. Proteins for DPF3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0071565nBAF complex ISS--

    DPF3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5/8 InterPro protein domains (see all 8):
     IPR015880 Znf_C2H2-like
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR025750 Requiem/DPF_N_dom

    Graphical View of Domain Structure for InterPro Entry Q92784

    ProtoNet protein and cluster: Q92784

    UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784
    Domain: The PHD-type zinc fingers mediate the binding to acetylated histones
    Similarity: Belongs to the requiem/DPF family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 2 PHD-type zinc fingers


    DPF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPF3_HUMAN, Q92784
    Function: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a
    switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell
    cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells
    to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural
    progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and
    PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in
    neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of
    the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of
    genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein
    complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration
    of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac,
    H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and
    methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle
    development

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS8812431
    GO:0046872metal ion binding ----
         
    DPF3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DPF3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPF3 
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    SwitchGear 3'UTR luciferase reporter plasmidDPF3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for DPF3 (Q927843 ENSP000003817914) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESRRAP114743, ENSP000000004424I2D: score=1 STRING: ENSP00000000442
    CTSBP078583I2D: score=4 
    IRF2BP2Q7Z5L93I2D: score=3 
    ACTL6AENSP000003975524STRING: ENSP00000397552
    ACTL6BENSP000001603824STRING: ENSP00000160382
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007399nervous system development IEA--
    GO:0008150biological_process ND--
    GO:0016568chromatin modification IEA--

    DPF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPF3

    Search CenterWatch for drugs/clinical trials and news about DPF3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DPF3 gene (4 alternative transcripts): 
    NM_001280542.1  NM_001280543.1  NM_001280544.1  NM_012074.4  

    Unigene Cluster for DPF3:

    D4, zinc and double PHD fingers, family 3
    Hs.162868  [show with all ESTs]
    Unigene Representative Sequence: AK024141
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556509(uc001xnc.2) ENST00000557704(uc001xnd.1) ENST00000366353
    ENST00000381216(uc001xnf.2) ENST00000546183 ENST00000556891 ENST00000556997
    ENST00000556238 ENST00000554594 ENST00000555781 ENST00000553608 ENST00000556902
    ENST00000555469 ENST00000541685(uc010ari.1 uc010ttq.1)
    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DPF3 (see all 28):
    hsa-miR-199b-3p hsa-miR-106a hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-218 hsa-miR-515-5p hsa-miR-9 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidDPF3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK024141.1 AK123045.1 AK124615.1 AK126074.1 AK294425.1 AY803021.1 BC021812.1 

    10 DOTS entries:

    DT.101982384  DT.97836363  DT.410381  DT.427144  DT.406091  DT.91653870  DT.100738740  DT.104059 
    DT.101982382  DT.443455 

    24/101 AceView cDNA sequences (see all 101):

    AW978703 AI628765 AI125562 BM805160 H72344 AW771496 H49646 F12896 
    AK126074 BU727351 AI479192 AA308399 AK123045 BF515253 F02123 Z38944 
    F05876 AA909451 BE463687 AI361027 BM674729 AA714655 BM717362 AW236736 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPF3 expression in normal human tissues (normalized intensities)      DPF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DPF3 Expression
    About this image


    DPF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Mononuclear Myocytes Hyoid Arch Muscles
             deltoid muscle   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             cerebellum   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Rod Cells Outer Nuclear Layer
             Retina
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Endothelium (Cardiovascular System)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...

    See DPF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPF3

    SOURCE GeneReport for Unigene cluster: Hs.162868
        SABiosciences Custom PCR Arrays for DPF3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DPF3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpf31 , 5 D4, zinc and double PHD fingers, family 31, 5 93.16(n)1
    99.44(a)1
      12 (38.47 cM)5
    701271  NM_058212.21  NP_478119.11 
     832137455 
    chicken
    (Gallus gallus)
    Aves DPF36
    zinc finger protein DPF3
    63(a)
    1 ↔ 1
    5(25849516-25938558)
    lizard
    (Anolis carolinensis)
    Reptilia DPF36
    D4, zinc and double PHD fingers, family 3
    70(a)
    1 ↔ 1
    1(38547377-38787451)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.196392 Transcribed sequence with moderate similarity to protein more 75.97(n)    AL887191.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dpf36
    D4, zinc and double PHD fingers, family 3
    54(a)
    1 ↔ 1
    20(28460476-28529533)
    fruit fly
    (Drosophila melanogaster)
    Insecta d46
    tth6
    toothrin
    19(a)
    15(a)
    many ↔ many
    many ↔ many
    2R(1147484-1183475)
    X(13507226-13510436)
    worm
    (Caenorhabditis elegans)
    Secernentea dpff-16
    Uncharacterized zinc finger protein C28H8.9
    21(a)
    1 → many
    III(5903574-5906122)


    ENSEMBL Gene Tree for DPF3 (if available)
    TreeFam Gene Tree for DPF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPF3 gene
    PHF102  DPF22  DPF12  
    2 SIMAP similar genes for DPF3 using alignment to 4 protein entries:     DPF3_HUMAN (see all proteins):
    DPF2    DPF1

    DPF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4836 SNPs in DPF3 are shown (see all 4836)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889981571,2
    --73136368(+) CCATTC/TTCTCT 1 -- ds50010--------
    rs732981581,2
    C,F--73136453(+) ACCTAT/CGCCAG 1 -- ds50014Minor allele frequency- C:0.25WA CSA EA 242
    rs2004209301,2
    C--73136573(+) AAGCT-/GGGGGG 1 -- ds50010--------
    rs793501961,2
    F--73136617(+) GATATG/AATGGT 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1508578001,2
    --73136676(+) GACCTC/TGCAGC 1 -- ut310--------
    rs2011551741,2
    C--73136733(+) CCCCA-/GGGGCC 1 -- ut310--------
    rs1146909391,2
    C,F--73136887(+) AAGGGG/AAGGGG 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs38148671,2
    C,F,H--73137025(-) CACTTT/CCCTCC 1 -- ut31 trp319Minor allele frequency- C:0.17EA NS NA WA CSA 3416
    rs1440311811,2
    --73137066(+) TCTACC/TGACGG 1 -- ut310--------
    rs1923671621,2
    --73137101(+) TGGTCA/GGGGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DPF3 (73086004 - 73336004 bp, first 250kb of DPF3)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DPF3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675309CNV Deletion23128226
    esv2748861CNV Deletion23290073
    nsv85673CNV Loss16902084
    nsv520843CNV Loss19592680
    esv32878CNV Loss17666407
    esv29330CNV Gain19812545
    nsv517683CNV Gain19592680
    esv260025OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601672    OMIM disorders: --

    4 diseases for DPF3:    About MalaCards
    tooth agenesis    cleft lip    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DPF3:
    Tooth agenesis

    DPF3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DPF3
    Human Genome Epidemiology (HuGE) Navigator: DPF3 (2 documents)

    Export disorders for DPF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPF3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with DPF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The d4 gene family in the human genome. (PubMed id 8812431)1, 2, 3 Chestkov A.V.... Buchman V.L. (1996)
    2. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PubMed id 11845289)1, 3, 9 Ninkina N.N....Buchman V.L. (2001)
    3. Mechanism and regulation of acetylated histone bindin g by the tandem PHD finger of DPF3b. (PubMed id 20613843)1, 2 Zeng L....Zhou M.M. (2010)
    4. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. (PubMed id 18765789)1, 2 Lange M.... Sperling S. (2008)
    5. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Double plant homeodomain (PHD) finger proteins DPF3a a nd -3b are required as transcriptional co-activators in SWI/SNF complex-dependen t activation of NF-kB RelA/p50 heterodimer. (PubMed id 22334708)1 Ishizaka A....Iba H. (2012)
    8. Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha throug h histone deacetylase 1. (PubMed id 20400511)1 Matsuyama R....Kato S. (2010)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases. (PubMed id 16109180)1 Hoyal C.R....Braun A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8110 HGNC: 17427 AceView: DPF3 Ensembl:ENSG00000205683 euGenes: HUgn8110
    ECgene: DPF3 H-InvDB: DPF3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DPF3 gene:
    Search GeneIP for patents involving DPF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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