Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DPF3 Gene

protein-coding   GIFtS: 48
GCID: GC14M073086

D4, zinc and double PHD fingers, family 3
 Explore 5 diseases affiliated with
DPF3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DPF3    

Aliases
for DPF3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
D4, Zinc And Double PHD Fingers, Family 31 2     FLJ140791
CERD42 3 5     Cer-D41
Zinc Finger Protein Cer-D42 3     2810403B03Rik2
BAF45C2 3     Cer-D4 Homolog2
BRG1-Associated Factor 45C2 3     Zinc Finger Protein DPF32
Cerd41     

External Ids:    HGNC: 174271   Entrez Gene: 81102   Ensembl: ENSG000002056837   OMIM: 6016725   UniProtKB: Q927843   

Export aliases for DPF3 gene to outside databases

Previous GC identifers: GC14M066871 GC14M071065 GC14M072145 GC14M053303


Summaries
for DPF3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784
Function: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a
switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle
and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to
post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors
exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are
exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific
complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural
stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite
growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in
transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome
topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac,
H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and
chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development




Genomic Views
for DPF3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DPF3 gene promoter:
         ATF-2   Cdc5   HNF-1A   E2F   E2F-1   FOXO4   HNF-1   Cart-1   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DPF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DPF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.2   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.2

DPF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPF3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M073086:  view genomic region     (about GC identifiers)

Start:
 73,075,742 bp from pter      End:
 73,360,809 bp from pter
Size:
 285,068 bases      Orientation:
 minus strand

Proteins
for DPF3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784 (See protein sequence)
Recommended Name: Zinc finger protein DPF3  
Size: 378 amino acids; 43084 Da
Subunit: Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2,
SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1,
and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains
DPF3. Interacts with acetylated histones H3 and H4. Component of neuron-specific chromatin remodeling complex (nBAF
complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,
SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C,
ACTL6B/BAF53B and actin (By similarity)
Subcellular location: Nucleus (Probable)
4 PDB 3D structures from and Proteopedia for DPF3:
2KWJ (3D)        2KWK (3D)        2KWN (3D)        2KWO (3D)    
Secondary accessions: A8MSI3 Q32UJ0 Q6P9E6 Q6ZT41 Q9H7Y5
Alternative splicing: 4 isoforms:  Q92784-1   Q92784-2   Q92784-3   Q92784-4   (Ref.2 (BAB14838) sequence differs from that shown due to a frameshift in position 187)

Explore the universe of human proteins at neXtProt for DPF3: NX_Q92784

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92784

    • DPF3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036206.3  
    ENSEMBL proteins: 
     ENSP00000438361   ENSP00000450518   ENSP00000381791   ENSP00000370614   ENSP00000444662  
     ENSP00000441640  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for DPF3 
    GenScript Custom Purified and Recombinant Proteins Services for DPF3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DPF3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus NAS--
    GO:0071565nBAF complex ISS--


    DPF3 for ontologies           About GeneDecksing



    DPF3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DPF3 
    GenScript Custom Superior Antibodies Services for DPF3
    Novus Biologicals DPF3 Antibody
    Search for Antibodies for DPF3 at Abcam  
    Uscn Antibodies for DPF3
    ThermoFisher Antibodies for DPF3

    Assay Products for DPF3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DPF3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DPF3

    Protein Domains /
    Families
    for DPF3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DPF3 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR015880 Znf_C2H2-like
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR025750 Requiem/DPF_N_dom

    Graphical View of Domain Structure for InterPro Entry Q92784

    ProtoNet protein and cluster: Q92784

    UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784
    Domain: The PHD-type zinc fingers mediate the binding to acetylated histones
    Similarity: Belongs to the requiem/DPF family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 2 PHD-type zinc fingers


    Function
    for DPF3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DPF3_HUMAN, Q92784
    Function: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a
    switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle
    and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to
    post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors
    exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are
    exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific
    complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural
    stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite
    growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in
    transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome
    topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac,
    H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and
    chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DPF3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPF3
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DPF3 (see all 28):
    hsa-miR-199b-3p hsa-miR-106a hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-218 hsa-miR-515-5p hsa-miR-9 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: DPF3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPF3 (see all 4)
    OriGene shRNA RFP: DPF3
    OriGene siRNA: DPF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPF3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DPF3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPF3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPF3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DPF3 (NM_012074)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DPF3
    Search LifeMap BioReagents cell lines for DPF3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0008270zinc ion binding NAS8812431


    DPF3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for DPF3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/25 Interacting proteins for DPF3 (Q927843 ENSP000003817914) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESRRAP114743, ENSP000000004424I2D: score=1 STRING: ENSP00000000442
    CTSBP078583I2D: score=4 
    IRF2BP2Q7Z5L93I2D: score=3 
    ACTL6AENSP000003975524STRING: ENSP00000397552
    ACTL6BENSP000001603824STRING: ENSP00000160382
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007399nervous system development IEA--
    GO:0008150biological_process ND--
    GO:0016568chromatin modification IEA--


    DPF3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DPF3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DPF3
    Search CenterWatch for drugs/clinical trials and news about DPF3 

    Transcripts
    for DPF3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DPF3 gene: 
    NM_012074.3  

    Unigene Cluster for DPF3:

    D4, zinc and double PHD fingers, family 3
    Hs.162868  [show with all ESTs]
    Unigene Representative Sequence: AK024141
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540281 ENST00000556509(uc001xnc.2) ENST00000557704(uc001xnd.1)
    ENST00000366353 ENST00000381216(uc001xnf.2) ENST00000546183 ENST00000556891
    ENST00000556997 ENST00000556238 ENST00000554594 ENST00000555781 ENST00000553608
    ENST00000556902 ENST00000555469 ENST00000541685(uc010ari.1 uc010ttq.1)


    miRNA
    Products:             		 OriGene 3'-UTR Clone: DPF3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DPF3
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate DPF3 (see all 28):
    hsa-miR-199b-3p hsa-miR-106a hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-218 hsa-miR-515-5p hsa-miR-9 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: DPF3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPF3 (see all 4)
    OriGene shRNA RFP: DPF3
    OriGene siRNA: DPF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPF3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPF3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPF3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DPF3 (NM_012074)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPF3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPF3

    Additional cDNA sequence: 

    AK024141.1 AK123045.1 AK124615.1 AK126074.1 AK294425.1 AY803021.1 BC021812.1 

    10 DOTS entries:

    DT.101982384  DT.97836363  DT.410381  DT.427144  DT.406091  DT.91653870  DT.100738740  DT.104059 
    DT.101982382  DT.443455 

    24/101 AceView cDNA sequences (see all 101):

    AI361027 AI628765 AW978703 F02123 BM674729 AK123045 BU727351 AA909451 
    AW236736 BE463687 F12896 BM805160 H49646 AA308399 AI125562 F05876 
    Z38944 AW771496 BF515253 AI479192 H72344 AK126074 BM717362 AA714655 

    GeneLoc Exon Structure


    Expression
    for DPF3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DPF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DPF3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    EyeRetinaEye
    HeartInterventricular SeptumHeart
    HeartLeft VentricleHeart
    HeartPrimitive Heart TubeHeart
    HeartRight VentricleHeart
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DPF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DPF3

    SOURCE GeneReport for Unigene cluster: Hs.162868
        SABiosciences Custom PCR Arrays for DPF3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPF3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPF3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPF3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPF3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF3

    Orthologs
    for DPF3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DPF3 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DPF36
    		 cer-d4
    		 64(a)
    		 1 ↔ 1
    		 5(28669152-28827244)
    lizard
    (Anolis carolinensis)    		 Reptilia DPF36
    		 --
    		 69(a)
    		 1 ↔ 1
    		 1(38550583-38678192)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.196392 Transcribed sequence with moderate similarity to protein more 75.97(n)    AL887191.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii dpf36
    		 D4, zinc and double PHD fingers, family 3
    		 54(a)
    		 possible ortholog
    		 20(28460476-28529533)
    fruit fly
    (Drosophila melanogaster)    		 Insecta d46
    		 d4
    		 18(a)
    		 1 → many
    		 2R(1147484-1183475)
    worm
    (Caenorhabditis elegans)    		 Secernentea dpff-16
    		 Uncharacterized zinc finger protein C28H8.9
    		 20(a)
    		 possible ortholog
    		 III(5903529-5906077)


    ENSEMBL Gene Tree for DPF3 (if available)
    TreeFam Gene Tree for DPF3 (if available) 

    Paralogs
    for DPF3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DPF3 gene
    PHF102  DPF22  DPF12  
    2 SIMAP similar genes for DPF3 using alignment to 4 protein entries:     DPF3_HUMAN (see all proteins):
    DPF2    DPF1

    DPF3 for paralogs           About GeneDecksing



    Genomic Variants
    for DPF3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4164 NCBI SNPs in DPF3 are shown (see all 4164)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1889981571,2
    		--73136368(+) CCATTC/TTCTCT 1 -- ds50010--------
    rs732981581,2
    		C,F,--73136453(+) ACCTAT/CGCCAG 1 -- ds50014Minor allele frequency- C:0.25WA CSA EA 242
    rs2004209301,2
    		--73136573(+) AAGCT-/GGGGGG 1 -- ds50010--------
    rs793501961,2
    		F,--73136617(+) GATATG/AATGGT 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1508578001,2
    		--73136676(+) GACCTC/TGCAGC 1 -- ut310--------
    rs2011551741,2
    		--73136733(+) CCCCA-/GGGGCC 1 -- ut310--------
    rs1146909391,2
    		C,F,--73136887(+) AAGGGG/AAGGGG 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs38148671,2
    		C,F,H,--73137025(-) CACTTT/CCCTCC 1 -- ut31 trp319Minor allele frequency- C:0.17EA NS NA WA CSA 3416
    rs1440311811,2
    		--73137066(+) TCTACC/TGACGG 1 -- ut310--------
    rs1923671621,2
    		--73137101(+) TGGTCA/GGGGCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DPF3 (73075742 - 73325742 bp, first 250kb of DPF3)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for DPF3
         3 CNVs: 76670 49407 66661
         3 Indels: 11086 40055 76671

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPF3
    DNA2.0 Custom Variant and Variant Library Synthesis for DPF3

    Disorders / Diseases
    for DPF3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DPF3 for disorders           About GeneDecksing

    OMIM gene information: 601672    OMIM disorders: --

    5 diseases for DPF3:    About MalaCards
    cleft lip/palate    cleft lip    tooth agenesis    breast cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DPF3:
    Tooth agenesis
    Human Genome Epidemiology (HuGE) Navigator: DPF3 (2 documents)

    Export disorders for DPF3 gene to outside databases

    Publications
    for DPF3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DPF3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with DPF3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The d4 gene family in the human genome. (PubMed id 8812431)1, 2, 3 Chestkov A.V.... Buchman V.L. (1996)
    2. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PubMed id 11845289)1, 3, 9 Ninkina N.N....Buchman V.L. (2001)
    3. Mechanism and regulation of acetylated histone bindin g by the tandem PHD finger of DPF3b. (PubMed id 20613843)1, 2 Zeng L....Zhou M.M. (2010)
    4. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. (PubMed id 18765789)1, 2 Lange M.... Sperling S. (2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Double plant homeodomain (PHD) finger proteins DPF3a a nd -3b are required as transcriptional co-activators in SWI/SNF complex-dependen t activation of NF-kB RelA/p50 heterodimer. (PubMed id 22334708)1 Ishizaka A....Iba H. (2012)
    7. Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha throug h histone deacetylase 1. (PubMed id 20400511)1 Matsuyama R....Kato S. (2010)
    8. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1 Vieira A.R....Marazita M.L. (2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases. (PubMed id 16109180)1 Hoyal C.R....Braun A. (2005)

    External Searches for DPF3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DPF3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8110 HGNC: 17427 AceView: DPF3 Ensembl:ENSG00000205683 euGenes: HUgn8110
    ECgene: DPF3 H-InvDB: DPF3

    Other Databases showing DPF3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DPF3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DPF3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DPF3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DPF3 gene:
    Search GeneIP for patents involving DPF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DPF3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DPF3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPF3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPF3  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DPF3   OriGene 3'-UTR Clone for DPF3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPF3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPF3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DPF3   OriGene Custom Protein Services for DPF3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPF3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPF3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPF3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPF3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPF3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPF3
     GenScript Custom Purified and Recombinant Proteins Services for DPF3 GenScript cDNA clones with any tag delivered in your preferred vector for DPF3
     GenScript Custom Assay Services for DPF3 GenScript Custom Superior Antibodies Services for DPF3
     GenScript Custom overexpressing Cell Line Services for DPF3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DPF3 promoter
     Search Chromatin IP Primers for DPF3
     RT2 qPCR Primer Assay in human, mouse, rat DPF3
     Search GNC Networks for DPF3
     SABiosciences Custom PCR Arrays for DPF3
     Search Tocris compounds for DPF3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DPF3 antibodies
     Search for Antibodies for DPF3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DPF3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DPF3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DPF3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF3
     SwitchGear 3'UTR luciferase reporter plasmids for DPF3
     SwitchGear Promoter luciferase reporter plasmids for DPF3
     ThermoFisher Antibodies for DPF3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DPF3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4