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DPF2 Gene

protein-coding   GIFtS: 56
GCID: GC11P065103

D4, Zinc And Double PHD Fingers Family 2

(Previous names: requiem, apoptosis response zinc finger gene)
(Previous symbol: REQ)
  See DPF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
D4, Zinc And Double PHD Fingers Family 21 2 3     BRG1-Associated Factor 45D2 3
REQ1 2 3 5     Requiem, Apoptosis Response Zinc Finger Gene1
UBID42 3 5     Requiem, Apoptosis Response Zinc Finger2
Apoptosis Response Zinc Finger Protein2 3     ubi-d42
Protein Requiem2 3     Zinc Finger Protein Ubi-D42
BAF45D2 3     

External Ids:    HGNC: 99641   Entrez Gene: 59772   Ensembl: ENSG000001338847   OMIM: 6016715   UniProtKB: Q927853   

Export aliases for DPF2 gene to outside databases

Previous GC identifers: GC11P065351 GC11P064876 GC11P064858 GC11P061428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPF2 Gene:
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like
structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response
following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth
and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited
cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. (provided by RefSeq, Jul
2008)

GeneCards Summary for DPF2 Gene:
DPF2 (D4, zinc and double PHD fingers family 2) is a protein-coding gene. Diseases associated with DPF2 include pituitary tumors. An important paralog of this gene is DPF3.

UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785
Function: May be a transcription factor required for the apoptosis response following survival factor withdrawal
from myeloid cells. Might also have a role in the development and maturation of lymphoid cells

Gene Wiki entry for DPF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPF2 gene promoter:
         Sox5   Elk-1   AML1a   Sp1   STAT5A   LCR-F1   IRF-2   NRF-2   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPF2 promoter sequence
   Search Chromatin IP Primers for DPF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

DPF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPF2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P065103:  view genomic region     (about GC identifiers)

Start:
65,101,225 bp from pter      End:
65,120,720 bp from pter
Size:
19,496 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785 (See protein sequence)
Recommended Name: Zinc finger protein ubi-d4  
Size: 391 amino acids; 44155 Da
1 PDB 3D structure from and Proteopedia for DPF2:
3IUF (3D)    
Secondary accessions: A8K7C9

Explore the universe of human proteins at neXtProt for DPF2: NX_Q92785

Explore proteomics data for DPF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys108
  • Modification sites at PhosphoSitePlus

  • See DPF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006259.1  
    ENSEMBL proteins: 
     ENSP00000436901   ENSP00000399714   ENSP00000252268   ENSP00000434885   ENSP00000435887  

    DPF2 Human Recombinant Protein Products:

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    Novus Biologicals DPF2 Proteins
    Novus Biologicals DPF2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DPF2

     
    Search eBioscience for Proteins for DPF2 

    DPF2 Antibody Products:

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    Search eBioscience for ELISAs for DPF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 8):
     IPR015880 Znf_C2H2-like
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR025750 Requiem/DPF_N_dom

    Graphical View of Domain Structure for InterPro Entry Q92785

    ProtoNet protein and cluster: Q92785

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785
    Similarity: Belongs to the requiem/DPF family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 2 PHD-type zinc fingers


    Find genes that share domains with DPF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REQU_HUMAN, Q92785
    Function: May be a transcription factor required for the apoptosis response following survival factor withdrawal
    from myeloid cells. Might also have a role in the development and maturation of lymphoid cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with DPF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DPF2:
     Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dpf2):
     normal 

    Find genes that share phenotypes with DPF2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DPF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPF2

    miRNA
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    miRTarBase miRNAs that target DPF2:
    hsa-mir-124-3p (MIRT022792), hsa-let-7b-5p (MIRT032431)

    Block miRNA regulation of human, mouse, rat DPF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPF2 (see all 34):
    hsa-let-7d hsa-miR-486-3p hsa-miR-759 hsa-let-7g hsa-let-7a hsa-miR-4325 hsa-miR-98 hsa-miR-409-3p
    SwitchGear 3'UTR luciferase reporter plasmidDPF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DPF2
    Predesigned siRNA for gene silencing in human, mouse, rat DPF2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DPF2 (NM_006268)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF2
    Addgene plasmids for DPF2 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DPF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    REQU_HUMAN, Q92785: Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with DPF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DPF2 About    
    See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for DPF2
        TNF-alpha/NF-kB Signaling Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including DPF2: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DPF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DPF2 (Q927852, 3 ENSP000002522684) via UniProtKB, MINT, STRING, and/or I2D (see all 634)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process TAS8812431
    GO:0097190apoptotic signaling pathway TAS7961935

    Find genes that share ontologies with DPF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPF2 (REQU)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPF2 gene: 
    NM_006268.4  

    Unigene Cluster for DPF2:

    D4, zinc and double PHD fingers family 2
    Hs.13495  [show with all ESTs]
    Unigene Representative Sequence: BX641135
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528416(uc001odm.3 uc010roe.2) ENST00000444314 ENST00000415073
    ENST00000530993 ENST00000252268 ENST00000524666 ENST00000532264 ENST00000532102
    ENST00000530973 ENST00000532492 ENST00000532052 ENST00000531989
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DPF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPF2 (see all 34):
    hsa-let-7d hsa-miR-486-3p hsa-miR-759 hsa-let-7g hsa-let-7a hsa-miR-4325 hsa-miR-98 hsa-miR-409-3p
    SwitchGear 3'UTR luciferase reporter plasmidDPF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DPF2
    Predesigned siRNA for gene silencing in human, mouse, rat DPF2
    Clone
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    OriGene clones in human, mouse for DPF2 (see all 6)
    OriGene ORF clones in mouse, rat for DPF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DPF2 (NM_006268)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF2
    Addgene plasmids for DPF2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DPF2
    OriGene qSTAR qPCR primer pairs in human, mouse for DPF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPF2
      QuantiTect SYBR Green Assays in human, mouse, rat DPF2
      QuantiFast Probe-based Assays in human, mouse, rat DPF2

    Additional mRNA sequence: 

    AF001433.1 AK096796.1 AK291944.1 AK300061.1 AK313408.1 BC014889.2 BT006718.1 BX641135.1 
    U94585.1 

    12 DOTS entries:

    DT.217684  DT.217685  DT.101963378  DT.100811802  DT.100811801  DT.92448478  DT.100640343  DT.95321723 
    DT.95321693  DT.100811804  DT.97789805  DT.97846930 

    Selected AceView cDNA sequences (see all 275):

    BX412755 AI475048 BQ927127 BE384951 BU541863 BU859090 CA396989 BU192666 
    AW005914 AI151156 BQ057470 BU630246 AI660331 AA470708 BU195721 AI338144 
    CR620712 CR614117 AU142186 BC014889 BM272623 AU107625 CB268096 BM478588 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DPF2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                                                          -                 -                     
    SP2:                                            -     -                       -                                       
    SP3:              -                                                                                                   
    SP4:                    -     -                 -     -                                                               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for DPF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGACACC
    DPF2 Expression
    About this image


    DPF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
    DPF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.13495

    UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including DPF2: 
              Apoptosis 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DPF2
    OriGene qSTAR qPCR primer pairs in human, mouse for DPF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPF2
    QuantiTect SYBR Green Assays in human, mouse, rat DPF2
    QuantiFast Probe-based Assays in human, mouse, rat DPF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPF2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpf21 , 5 D4, zinc and double PHD fingers family 21, 5 90.54(n)1
    98.47(a)1
      19 (4.34 cM)5
    197081  NM_011262.41  NP_035392.11 
     58965165 
    chicken
    (Gallus gallus)
    Aves DPF21 D4, zinc and double PHD fingers family 2 82.1(n)
    96.42(a)
      374236  NM_204331.1  NP_989662.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    96(a)
    87(a)
    1 ↔ many
    1 ↔ many
    GL344791.1(32-8332)
    AAWZ02039803(745-7530)
    African clawed frog
    (Xenopus laevis)
    Amphibia req-A2 requiem, apoptosis response zinc finger gene 78.37(n)    AB021741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY391455.12   -- 77.66(n)    AY391455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta d46
    tth6
    toothrin
    32(a)
    15(a)
    many ↔ many
    many ↔ many
    2R(1147484-1183475)
    X(13507226-13510436)
    worm
    (Caenorhabditis elegans)
    Secernentea dpff-16
    Protein DPFF-1, isoform b (dpff-1) mRNA, complete ...
    33(a)
    1 → many
    III(5903574-5906122) WBGene00016200


    ENSEMBL Gene Tree for DPF2 (if available)
    TreeFam Gene Tree for DPF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPF2 gene
    DPF32  PHF102  DPF12  
    2 SIMAP similar genes for DPF2 using alignment to 5 protein entries:     REQU_HUMAN (see all proteins):
    DPF3    DPF1

    Find genes that share paralogs with DPF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DPF2
    PGOHUM00000243367


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPF2 (see all 494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs761136861,2
    C,F--65099234(+) ACCTAC/TGATGT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs802190651,2
    F--65099250(+) CAAAAA/CTTAAA 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1876095611,2
    --65099287(+) GAACCC/GGGAAG 1 -- us2k10--------
    rs1922238021,2
    --65099476(+) GGCTAC/GCTGCA 1 -- us2k10--------
    rs1128575721,2
    C,F--65099757(+) TTGAAC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1167428191,2
    C,F--65099893(+) AAATAA/CTGTTG 1 -- us2k13Minor allele frequency- C:0.11WA NA EA 358
    rs1840066571,2
    --65099980(+) GTGGCA/GCGATC 1 -- us2k10--------
    rs1138152911,2
    C,F--65099990(+) CTTGGG/CTCACT 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1886949691,2
    --65100068(+) CGTCCA/GCCACC 1 -- us2k10--------
    rs287812781,2
    C--65100137(+) CAGGAC/TGGTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DPF2 (65101225 - 65120720 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DPF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422285CNV Deletion17116639
    nsv832190CNV Loss17160897
    dgv1175n71CNV Loss21882294
    nsv526181CNV Gain19592680
    nsv825950CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601671    OMIM disorders: --

    1 disease for DPF2:    
    About MalaCards
    pituitary tumors


    Find genes that share disorders with DPF2           About GenesLikeMe


    Export disorders for DPF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPF2 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with DPF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. (PubMed id 21888896)1, 2 Zhang W.... Qi C. (Biochem. Biophys. Res. Commun. 2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PubMed id 11845289)1, 3 Ninkina N.N....Buchman V.L. (Mamm. Genome 2001)
    5. Expression and chromosomal localization of the Requiem gene. (PubMed id 9680388)1, 2 Gabig T.G.... Weber G. (Mamm. Genome 1998)
    6. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PubMed id 9253601)1, 2 Guru S.C.... Chandrasekharappa S.C. (Genome Res. 1997)
    7. The d4 gene family in the human genome. (PubMed id 8812431)1, 2 Chestkov A.V.... Buchman V.L. (Genomics 1996)
    8. Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach. (PubMed id 23281010)1 Li X....Kapoor T.M. (Protein Sci. 2013)
    9. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    10. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5977 HGNC: 9964 AceView: DPF2 Ensembl:ENSG00000133884 euGenes: HUgn5977
    ECgene: DPF2 H-InvDB: DPF2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DPF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DPF2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/req/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPF2 gene:
    Search GeneIP for patents involving DPF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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