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Aliases for DPF2 Gene

Aliases for DPF2 Gene

  • Double PHD Fingers 2 2 3
  • D4, Zinc And Double PHD Fingers Family 2 2 3 4 5
  • Apoptosis Response Zinc Finger Protein 3 4
  • BRG1-Associated Factor 45D 3 4
  • Protein Requiem 3 4
  • BAF45D 3 4
  • UBID4 3 4
  • REQ 3 4
  • Requiem, Apoptosis Response Zinc Finger Gene 2
  • Requiem, Apoptosis Response Zinc Finger 3
  • Ubi-D4 3

External Ids for DPF2 Gene

Previous HGNC Symbols for DPF2 Gene

  • REQ

Previous GeneCards Identifiers for DPF2 Gene

  • GC11P064876
  • GC11P064858
  • GC11P065103
  • GC11P061428

Summaries for DPF2 Gene

Entrez Gene Summary for DPF2 Gene

  • The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPF2 Gene

DPF2 (Double PHD Fingers 2) is a Protein Coding gene. Diseases associated with DPF2 include multiple endocrine neoplasia. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is PHF10.

UniProtKB/Swiss-Prot for DPF2 Gene

  • May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Gene Wiki entry for DPF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPF2 Gene

Genomics for DPF2 Gene

Regulatory Elements for DPF2 Gene

Promoters for DPF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPF2 Gene

Chromosome:
11
Start:
65,333,754 bp from pter
End:
65,353,249 bp from pter
Size:
19,496 bases
Orientation:
Plus strand

Genomic View for DPF2 Gene

Genes around DPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPF2 Gene

Proteins for DPF2 Gene

  • Protein details for DPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92785-REQU_HUMAN
    Recommended name:
    Zinc finger protein ubi-d4
    Protein Accession:
    Q92785
    Secondary Accessions:
    • A8K7C9
    • B4DT58

    Protein attributes for DPF2 Gene

    Size:
    391 amino acids
    Molecular mass:
    44155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DPF2 Gene

    Alternative splice isoforms for DPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPF2 Gene

Proteomics data for DPF2 Gene at MOPED

Post-translational modifications for DPF2 Gene

  • Ubiquitination at Lys 59 and Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for DPF2 Gene

No data available for DME Specific Peptides for DPF2 Gene

Domains & Families for DPF2 Gene

Gene Families for DPF2 Gene

Suggested Antigen Peptide Sequences for DPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92785

UniProtKB/Swiss-Prot:

REQU_HUMAN :
  • Belongs to the requiem/DPF family.
  • Contains 1 C2H2-type zinc finger.
Family:
  • Belongs to the requiem/DPF family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with DPF2: view

Function for DPF2 Gene

Molecular function for DPF2 Gene

UniProtKB/Swiss-Prot Function:
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.
genes like me logo Genes that share phenotypes with DPF2: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPF2 Gene

Localization for DPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPF2 Gene

Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPF2 Gene COMPARTMENTS Subcellular localization image for DPF2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
genes like me logo Genes that share ontologies with DPF2: view

Pathways & Interactions for DPF2 Gene

genes like me logo Genes that share pathways with DPF2: view

Pathways by source for DPF2 Gene

1 BioSystems pathway for DPF2 Gene

Gene Ontology (GO) - Biological Process for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS 8812431
GO:0097190 apoptotic signaling pathway TAS 7961935
genes like me logo Genes that share ontologies with DPF2: view

No data available for SIGNOR curated interactions for DPF2 Gene

Drugs & Compounds for DPF2 Gene

No Compound Related Data Available

Transcripts for DPF2 Gene

Unigene Clusters for DPF2 Gene

D4, zinc and double PHD fingers family 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for DPF2 Gene

GeneLoc Exon Structure for
DPF2
ECgene alternative splicing isoforms for
DPF2

Expression for DPF2 Gene

mRNA expression in normal human tissues for DPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPF2 Gene



SOURCE GeneReport for Unigene cluster for DPF2 Gene Hs.13495

mRNA Expression by UniProt/SwissProt for DPF2 Gene

Q92785-REQU_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DPF2: view

Protein tissue co-expression partners for DPF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DPF2 Gene

Orthologs for DPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPF2 35
  • 99.57 (n)
  • 100 (a)
DPF2 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPF2 36
  • 100 (a)
OneToOne
DPF2 35
  • 93.86 (n)
  • 99.74 (a)
dog
(Canis familiaris)
Mammalia DPF2 35
  • 92.5 (n)
  • 100 (a)
DPF2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpf2 16
Dpf2 36
  • 98 (a)
OneToOne
Dpf2 35
  • 90.54 (n)
  • 98.47 (a)
oppossum
(Monodelphis domestica)
Mammalia DPF2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPF2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpf2 35
  • 91.3 (n)
  • 99.23 (a)
chicken
(Gallus gallus)
Aves DPF2 36
  • 88 (a)
OneToOne
DPF2 35
  • 82.1 (n)
  • 96.42 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 96 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia req-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10851 35
dpf2 35
  • 76.28 (n)
  • 89.09 (a)
zebrafish
(Danio rerio)
Actinopterygii dpf2l 36
  • 74 (a)
OneToMany
dpf2 36
  • 78 (a)
OneToMany
dpf2 35
  • 72.15 (n)
  • 80.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta tth 36
  • 15 (a)
ManyToMany
d4 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dpff-1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12010 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for DPF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPF2 Gene

ENSEMBL:
Gene Tree for DPF2 (if available)
TreeFam:
Gene Tree for DPF2 (if available)

Paralogs for DPF2 Gene

Paralogs for DPF2 Gene

(2) SIMAP similar genes for DPF2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DPF2 Gene

genes like me logo Genes that share paralogs with DPF2: view

Variants for DPF2 Gene

Sequence variations from dbSNP and Humsavar for DPF2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs540341 -- 65,336,272(+) agatt(A/G)cttga intron-variant
rs615768 -- 65,342,275(-) tagag(A/G)caagg intron-variant
rs616639 -- 65,342,101(-) tTTTT(G/T)gttgc intron-variant
rs642848 -- 65,336,280(+) tgagg(C/T)cagga intron-variant
rs642860 -- 65,336,289(+) gagtt(C/T)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPF2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
nsv832190 CNV Loss 17160897
esv2422285 CNV Deletion 17116639
dgv1175n71 CNV Loss 21882294
nsv825950 CNV Gain 20364138

Variation tolerance for DPF2 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPF2 Gene

HapMap Linkage Disequilibrium report
DPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPF2 Gene

Disorders for DPF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DPF2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
multiple endocrine neoplasia
  • adenomatosis, familial endocrine
- elite association - COSMIC cancer census association via MalaCards
Search DPF2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPF2
genes like me logo Genes that share disorders with DPF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPF2 Gene

Publications for DPF2 Gene

  1. Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. (PMID: 21888896) Zhang W. … Qi C. (Biochem. Biophys. Res. Commun. 2011) 3 4 67
  2. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PMID: 11845289) Ninkina N.N. … Buchman V.L. (Mamm. Genome 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for DPF2 Gene

Sources for DPF2 Gene

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