DPF2 Gene
protein-coding GIFtS: 55
GCID: GC11P065103
|
|
D4, zinc and double PHD fingers family 2(Previous names: requiem, apoptosis response zinc finger gene )
(Previous symbol: REQ)
| |
Aliases
for DPF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| D4, Zinc And Double PHD Fingers Family 21 2 3 | | BAF45D2 3 | | REQ1 2 3 5 | | BRG1-Associated Factor 45D2 3 | | UBID42 3 5 | | Requiem, Apoptosis Response Zinc Finger Gene1 | | Ubi-D41 | | Requiem, Apoptosis Response Zinc Finger2 | | Apoptosis Response Zinc Finger Protein2 3 | | Zinc Finger Protein Ubi-D42 | | Protein Requiem2 3 | | |
Export aliases for DPF2 gene to outside databasesPrevious GC identifers: GC11P065351 GC11P064876 GC11P064858 GC11P061428 |
Summaries
for DPF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DPF2:
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structuralmotif. This protein functions as a transcription factor which is necessary for the apoptotic response followingdeprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover.This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndromeinvolving multiple parathyroid, enteropancreatic, and pituitary tumors. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785Function: May be a transcription factor required for the apoptosis response following survival factor withdrawal frommyeloid cells. Might also have a role in the development and maturation of lymphoid cells
Gene Wiki entry for DPF2
|
Genomic Views
for DPF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DPF2 gene promoter:
Sox5 Elk-1 AML1a Sp1 STAT5A LCR-F1 IRF-2 NRF-2 SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for DPF2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPF2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1DPF2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P065103: view genomic region
(about GC identifiers)
Start:
|
65,101,225 bp from pter |
End:
|
65,120,720 bp from pter |
Size:
|
19,496 bases |
Orientation:
|
plus strand |
|
Proteins
for DPF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785 (See
protein sequence)Recommended Name: Zinc finger protein ubi-d4 Size: 391 amino acids; 44155 Da
Subcellular location: Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic
1 PDB 3D structure from  and Proteopedia  for DPF2:3IUF (3D)
Secondary accessions: A8K7C9Explore the universe of human proteins at neXtProt for DPF2: NX_Q92785
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92785
DPF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006259.1
ENSEMBL proteins: ENSP00000436901 ENSP00000399714 ENSP00000252268 ENSP00000434885 ENSP00000435887
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DPF2 for ontologies About GeneDecksing
DPF2 Antibody Products:
Assay Products for DPF2: |
Protein
Domains /
Families
for DPF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPF2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q92785ProtoNet protein and cluster: Q92785 2 Blocks protein families: IPB001841 Zn-finger IPB001965 Zn-finger-like
UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785Similarity: Belongs to the requiem/DPF familySimilarity: Contains 1 C2H2-type zinc fingerSimilarity: Contains 2 PHD-type zinc fingers |
Function
for DPF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785Function: May be a transcription factor required for the apoptosis response following survival factor withdrawal frommyeloid cells. Might also have a role in the development and maturation of lymphoid cells
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPF2
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
DPF2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DPF2:
|
Pathways & Interactions
for DPF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TNF-alpha/NF-kB Signaling Pathway | |
1  BioSystems Pathway for DPF2
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/594 Interacting proteins for DPF2 (Q927852, 3 ENSP000002522684) via UniProtKB, MINT, STRING, and/or I2D (see all 594)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
DPF2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DPF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DPF2
Search CenterWatch for drugs/clinical trials and news about DPF2 / REQU
|
Transcripts
for DPF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DPF2 gene: NM_006268.4 Unigene Cluster for DPF2: D4, zinc and double PHD fingers family 2 Hs.13495 [show with all ESTs]Unigene Representative Sequence: BX64113512 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528416(uc001odm.3 uc010roe.2) ENST00000444314 ENST00000415073
ENST00000530993 ENST00000252268 ENST00000524666 ENST00000532264 ENST00000532102
ENST00000530973 ENST00000532492 ENST00000532052 ENST00000531989
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPF2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPF2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DPF2 (NM_006268) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPF2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF2 |
Additional cDNA sequence: AF001433.1 AK096796.1 AK291944.1 AK300061.1 AK313408.1 BC014889.2 BT006718.1 BX641135.1 U94585.1 12 DOTS entries: DT.217684 DT.217685 DT.101963378 DT.100811802 DT.100811801 DT.92448478 DT.100640343 DT.95321723 DT.95321693 DT.100811804 DT.97789805 DT.97846930 24/275 AceView cDNA sequences (see all 275): BU630246 BQ278665 CA396989 BU192666 AI475048 AA470708 BU195721 BU541863 BQ272558 T80399 BQ057470 AW014346 AI151156 AW005914 AI791296 BM838188 BQ927127 CB268096 BI836733 AI564030 AU142186 AI183331 CR620712 BX412755
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DPF2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DPF2
|
Expression
for DPF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGGACACC
About this image
See DPF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPF2
SOURCE GeneReport for Unigene cluster: Hs.13495
UniProtKB/Swiss-Prot: REQU_HUMAN, Q92785Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including DPF2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPF2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF2 |
Orthologs
for DPF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DPF2 gene from 6/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DPF21 |
D4, zinc and double PHD fingers family 2 |
82.1(n)
96.42(a) |
|
374236 NM_204331.1 NP_989662.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DPF26DPF26 |
-- |
99(a)85(a) |
1 ↔ 1possible ortholog |
GL344791.1(501-6981) AAWZ02039803(745-7530) |
African clawed frog
(Xenopus laevis) |
Amphibia |
req-A2 |
requiem, apoptosis response zinc finger gene |
78.37(n) |
|
AB021741.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AY391455.12 |
-- |
77.66(n) |
|
AY391455.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
d41 |
CG2682-PA |
49.63(n)
44.38(a) |
|
35485 NM_136319.3 NP_610163.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
dpff-11 |
Protein DPFF-1 |
46.49(n)
39.76(a) |
|
175832 NM_065880.4 NP_498281.2 |
ENSEMBL Gene Tree for DPF2 (if available)
TreeFam Gene Tree for DPF2 (if available) |
Paralogs
for DPF2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DPF2 gene
- DPF32 PHF102 DPF12
2 SIMAP similar genes for DPF2 using alignment to 5 protein entries: REQU_HUMAN (see all proteins):DPF3 DPF1
DPF2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DPF2
PGOHUM00000243367
|
Genomic Variants
for DPF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DPF2 (65101225 - 65120720 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DPF2
1 CNV: 5423 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPF2 |
|
Disorders
/ Diseases
for DPF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPF2 for disorders About GeneDecksing
OMIM gene information: 601671
OMIM disorders: --
5  diseases for DPF2: About MalaCardsmultiple endocrine neoplasia pituitary tumor fanconi's anemia nephropathy
anemia
Export disorders for DPF2 gene to outside databases
|
Publications
for DPF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPF2 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with DPF2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Crystal structure of the Cys2His2-type zinc finger do main of human DPF2. (PubMed id 21888896)1, 2 Zhang W....Qi C. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PubMed id 11845289)1, 3 Ninkina N.N....Buchman V.L. (2001)
- Expression and chromosomal localization of the Requiem gene. (PubMed id 9680388)1, 2 Gabig T.G.... Weber G. (1998)
- A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PubMed id 9253601)1, 2 Guru S.C....Chandrasekharappa S.C. (1997)
- The d4 gene family in the human genome. (PubMed id 8812431)1, 2 Chestkov A.V.... Buchman V.L. (1996)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Double plant homeodomain (PHD) finger proteins DPF3a a nd -3b are required as transcriptional co-activators in SWI/SNF complex-dependen t activation of NF-kB RelA/p50 heterodimer. (PubMed id 22334708)1 Ishizaka A....Iba H. (2012)
|
External Searches for DPF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DPF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DPF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DPF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DPF2 gene:
Search GeneIP for patents involving DPF2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DPF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |
 |
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| |
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| |  |  |  |  | | | | |
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 |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF2 |
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|
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