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Aliases for DPF2 Gene

Aliases for DPF2 Gene

  • Double PHD Fingers 2 2 3 5
  • D4, Zinc And Double PHD Fingers Family 2 2 3 4
  • Apoptosis Response Zinc Finger Protein 3 4
  • BRG1-Associated Factor 45D 3 4
  • Protein Requiem 3 4
  • BAF45D 3 4
  • UBID4 3 4
  • REQ 3 4
  • Requiem, Apoptosis Response Zinc Finger Gene 2
  • Requiem, Apoptosis Response Zinc Finger 3
  • Zinc Finger Protein Ubi-D4 3
  • Ubi-D4 3

External Ids for DPF2 Gene

Previous HGNC Symbols for DPF2 Gene

  • REQ

Previous GeneCards Identifiers for DPF2 Gene

  • GC11P064876
  • GC11P064858
  • GC11P065103
  • GC11P061428

Summaries for DPF2 Gene

Entrez Gene Summary for DPF2 Gene

  • The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPF2 Gene

DPF2 (Double PHD Fingers 2) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is DPF1.

UniProtKB/Swiss-Prot for DPF2 Gene

  • May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Gene Wiki entry for DPF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPF2 Gene

Genomics for DPF2 Gene

Regulatory Elements for DPF2 Gene

Enhancers for DPF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G065910 1.8 FANTOM5 ENCODE dbSUPER 25.4 +582.0 581974 11.4 MLX AGO1 ZFP64 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 GLIS1 LOC105369352 ZFPL1 ENSG00000258297 RBM14 MUS81 KAT5 DPF2 ENSG00000254461 RNASEH2C EIF1AD
GH11G065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 14 +156.3 156330 40.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 LOC105369352 ZFPL1 KAT5 ENSG00000254461 EIF1AD NEAT1 FRMD8 EHBP1L1 POLA2 LOC101927789
GH11G065886 1.9 FANTOM5 ENCODE dbSUPER 17.2 +561.7 561705 18.4 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SNX32 CTSW MUS81 EIF1AD ENSG00000254461 KAT5 ZFPL1 RBM4B EFEMP2 ENSG00000258297
GH11G065377 2.1 FANTOM5 Ensembl ENCODE dbSUPER 14 +48.7 48728 10.3 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ENSG00000254461 LOC105369352 KAT5 NEAT1 DPF2 LOC728975 KLC2 SSSCA1-AS1 SNX15 ZFPL1
GH11G066150 1.1 ENCODE 25.4 +817.3 817306 2.0 HNRNPUL1 ARNT MLX ZFP64 ARID4B SIN3A ZBTB7B YY1 ZNF766 CBX5 ENSG00000258297 RBM14 LOC105369352 KAT5 MUS81 EIF1AD DPF2 ENSG00000254461 PCNX3 POLA2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPF2 on UCSC Golden Path with GeneCards custom track

Promoters for DPF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040815 447 2000 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF143 MXD4 REST

Genomic Location for DPF2 Gene

Chromosome:
11
Start:
65,333,754 bp from pter
End:
65,353,249 bp from pter
Size:
19,496 bases
Orientation:
Plus strand

Genomic View for DPF2 Gene

Genes around DPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPF2 Gene

Proteins for DPF2 Gene

  • Protein details for DPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92785-REQU_HUMAN
    Recommended name:
    Zinc finger protein ubi-d4
    Protein Accession:
    Q92785
    Secondary Accessions:
    • A8K7C9
    • B4DT58

    Protein attributes for DPF2 Gene

    Size:
    391 amino acids
    Molecular mass:
    44155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DPF2 Gene

    Alternative splice isoforms for DPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPF2 Gene

Post-translational modifications for DPF2 Gene

  • Ubiquitination at Lys59 and Lys108
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DPF2 Gene

Domains & Families for DPF2 Gene

Gene Families for DPF2 Gene

Suggested Antigen Peptide Sequences for DPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92785

UniProtKB/Swiss-Prot:

REQU_HUMAN :
  • Belongs to the requiem/DPF family.
Family:
  • Belongs to the requiem/DPF family.
genes like me logo Genes that share domains with DPF2: view

Function for DPF2 Gene

Molecular function for DPF2 Gene

UniProtKB/Swiss-Prot Function:
May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Gene Ontology (GO) - Molecular Function for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DPF2: view
genes like me logo Genes that share phenotypes with DPF2: view

Animal Models for DPF2 Gene

MGI Knock Outs for DPF2:
  • Dpf2 tm1b(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DPF2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DPF2 Gene

Localization for DPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPF2 Gene

Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPF2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with DPF2: view

Pathways & Interactions for DPF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS 8812431
GO:0097190 apoptotic signaling pathway TAS 7961935
genes like me logo Genes that share ontologies with DPF2: view

No data available for Pathways by source and SIGNOR curated interactions for DPF2 Gene

Transcripts for DPF2 Gene

Unigene Clusters for DPF2 Gene

D4, zinc and double PHD fingers family 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DPF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:

Relevant External Links for DPF2 Gene

GeneLoc Exon Structure for
DPF2
ECgene alternative splicing isoforms for
DPF2

Expression for DPF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DPF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPF2 Gene



Protein tissue co-expression partners for DPF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPF2 Gene:

DPF2

SOURCE GeneReport for Unigene cluster for DPF2 Gene:

Hs.13495

mRNA Expression by UniProt/SwissProt for DPF2 Gene:

Q92785-REQU_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DPF2 Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with DPF2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPF2 Gene

Orthologs for DPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPF2 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia DPF2 34 35
  • 93.86 (n)
oppossum
(Monodelphis domestica)
Mammalia DPF2 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPF2 34 35
  • 92.5 (n)
rat
(Rattus norvegicus)
Mammalia Dpf2 34
  • 91.3 (n)
mouse
(Mus musculus)
Mammalia Dpf2 34 16 35
  • 90.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DPF2 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPF2 34 35
  • 82.1 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 96 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dpf2 34
  • 76.28 (n)
Str.10851 34
African clawed frog
(Xenopus laevis)
Amphibia req-A 34
zebrafish
(Danio rerio)
Actinopterygii dpf2l 35
  • 74 (a)
OneToMany
dpf2 34 35
  • 72.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta d4 35
  • 32 (a)
ManyToMany
tth 35
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dpff-1 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12010 34
Species where no ortholog for DPF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPF2 Gene

ENSEMBL:
Gene Tree for DPF2 (if available)
TreeFam:
Gene Tree for DPF2 (if available)

Paralogs for DPF2 Gene

Paralogs for DPF2 Gene

(2) SIMAP similar genes for DPF2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for DPF2 Gene

genes like me logo Genes that share paralogs with DPF2: view

Variants for DPF2 Gene

Sequence variations from dbSNP and Humsavar for DPF2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000077930 -- 65,341,010(+) GCTGG(C/T)GGAAA nc-transcript-variant, reference, missense
rs1000323963 -- 65,334,903(+) GGTTC(A/G)GTAAC intron-variant
rs1000392770 -- 65,354,482(+) AGCTC(C/G)GCGGT downstream-variant-500B, upstream-variant-2KB
rs1000446606 -- 65,354,578(+) CGCCT(-/C)CCGCC downstream-variant-500B, upstream-variant-2KB
rs1000657096 -- 65,333,735(+) GAACA(A/G)GCGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPF2 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv526181 CNV gain 19592680
nsv825950 CNV gain 20364138
nsv832190 CNV loss 17160897

Variation tolerance for DPF2 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPF2 Gene

Disorders for DPF2 Gene

Relevant External Links for DPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPF2

No disorders were found for DPF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPF2 Gene

Publications for DPF2 Gene

  1. Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. (PMID: 21888896) Zhang W. … Qi C. (Biochem. Biophys. Res. Commun. 2011) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Cerd4, third member of the d4 gene family: expression and organization of genomic locus. (PMID: 11845289) Ninkina N.N. … Buchman V.L. (Mamm. Genome 2001) 2 3 64
  5. Expression and chromosomal localization of the Requiem gene. (PMID: 9680388) Gabig T.G. … Weber G. (Mamm. Genome 1998) 3 4 64

Products for DPF2 Gene

Sources for DPF2 Gene

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