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Aliases for DPF2 Gene

Aliases for DPF2 Gene

  • D4, Zinc And Double PHD Fingers Family 2 2 3 4
  • UBID4 3 4 6
  • REQ 3 4 6
  • Apoptosis Response Zinc Finger Protein 3 4
  • BRG1-Associated Factor 45D 3 4
  • Protein Requiem 3 4
  • BAF45D 3 4
  • Requiem, Apoptosis Response Zinc Finger Gene 2
  • Requiem, Apoptosis Response Zinc Finger 3
  • Zinc Finger Protein Ubi-D4 3
  • Ubi-D4 3

External Ids for DPF2 Gene

Previous Symbols for DPF2 Gene

  • REQ

Summaries for DPF2 Gene

Entrez Gene Summary for DPF2 Gene

  • The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPF2 Gene

DPF2 (D4, Zinc And Double PHD Fingers Family 2) is a Protein Coding gene. Diseases associated with DPF2 include pituitary tumors. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. An important paralog of this gene is DPF3.

UniProtKB/Swiss-Prot for DPF2 Gene

  • May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells

Gene Wiki entry for DPF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPF2 Gene

Genomics for DPF2 Gene

Genomic Location for DPF2 Gene

65,333,754 bp from pter
65,353,249 bp from pter
19,496 bases
Plus strand

Genomic View for DPF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPF2 Gene

Regulatory Elements for DPF2 Gene

Proteins for DPF2 Gene

  • Protein details for DPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein ubi-d4
    Protein Accession:
    Secondary Accessions:
    • A8K7C9
    • B4DT58

    Protein attributes for DPF2 Gene

    391 amino acids
    Molecular mass:
    44155 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DPF2 Gene

    Alternative splice isoforms for DPF2 Gene


neXtProt entry for DPF2 Gene

Proteomics data for DPF2 Gene at MOPED

Post-translational modifications for DPF2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys59 and Lys108

Other Protein References for DPF2 Gene

No data available for DME Specific Peptides for DPF2 Gene

Domains for DPF2 Gene

Gene Families for DPF2 Gene

  • PHF :Zinc fingers, PHD-type


  • Belongs to the requiem/DPF family.:
    • Q92785
  • Contains 1 C2H2-type zinc finger.:
    • Q92785
  • Contains 2 PHD-type zinc fingers.:
    • Q92785
genes like me logo Genes that share domains with DPF2: view

Function for DPF2 Gene

Molecular function for DPF2 Gene

UniProtKB/Swiss-Prot Function: May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells

Gene Ontology (GO) - Molecular Function for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DPF2: view

Phenotypes for DPF2 Gene

MGI mutant phenotypes for DPF2:
inferred from 1 alleles
GenomeRNAi human phenotypes for DPF2:
genes like me logo Genes that share phenotypes with DPF2: view

miRNA for DPF2 Gene

miRTarBase miRNAs that target DPF2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPF2 Gene

Localization for DPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPF2 Gene

Nucleus. Cytoplasm. Note=30% nuclear. 70% cytoplasmic.

Subcellular locations from

Jensen Localization Image for DPF2 Gene COMPARTMENTS Subcellular localization image for DPF2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 3

Gene Ontology (GO) - Cellular Components for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with DPF2: view

Pathways for DPF2 Gene

genes like me logo Genes that share pathways with DPF2: view

Pathways by source for DPF2 Gene

1 BioSystems pathway for DPF2 Gene

Gene Ontology (GO) - Biological Process for DPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS 8812431
GO:0097190 apoptotic signaling pathway TAS 7961935
genes like me logo Genes that share ontologies with DPF2: view

Transcripts for DPF2 Gene

Unigene Clusters for DPF2 Gene

D4, zinc and double PHD fingers family 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -

Relevant External Links for DPF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPF2 Gene

mRNA expression in normal human tissues for DPF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPF2 Gene

SOURCE GeneReport for Unigene cluster for DPF2 Gene Hs.13495

mRNA Expression by UniProt/SwissProt for DPF2 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with DPF2: view

Orthologs for DPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DPF2 36
  • 99.57 (n)
  • 100 (a)
DPF2 37
  • 96 (a)
(Bos Taurus)
Mammalia DPF2 36
  • 93.86 (n)
  • 99.74 (a)
DPF2 37
  • 100 (a)
(Canis familiaris)
Mammalia DPF2 36
  • 92.5 (n)
  • 100 (a)
DPF2 37
  • 100 (a)
(Mus musculus)
Mammalia Dpf2 36
  • 90.54 (n)
  • 98.47 (a)
Dpf2 16
Dpf2 37
  • 98 (a)
(Monodelphis domestica)
Mammalia DPF2 37
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia DPF2 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Dpf2 36
  • 91.3 (n)
  • 99.23 (a)
(Gallus gallus)
Aves DPF2 36
  • 82.1 (n)
  • 96.42 (a)
DPF2 37
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 87 (a)
-- 37
  • 96 (a)
African clawed frog
(Xenopus laevis)
Amphibia req-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dpf2 36
  • 76.28 (n)
  • 89.09 (a)
Str.10851 36
(Danio rerio)
Actinopterygii dpf2 36
  • 72.15 (n)
  • 80.46 (a)
dpf2 37
  • 78 (a)
dpf2l 37
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta d4 37
  • 32 (a)
tth 37
  • 15 (a)
(Caenorhabditis elegans)
Secernentea dpff-1 37
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12010 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
Species with no ortholog for DPF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPF2 Gene

Gene Tree for DPF2 (if available)
Gene Tree for DPF2 (if available)

Paralogs for DPF2 Gene

Paralogs for DPF2 Gene

Selected SIMAP similar genes for DPF2 Gene using alignment to 5 proteins: Pseudogenes for DPF2 Gene

genes like me logo Genes that share paralogs with DPF2: view

Variants for DPF2 Gene

Sequence variations from dbSNP and Humsavar for DPF2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs540341 -- 65,336,272(+) agatt(A/G)cttga intron-variant
rs610864 -- 65,335,147(+) CCAAC(A/G)CTATT intron-variant
rs615768 -- 65,342,275(-) tagag(A/G)caagg intron-variant
rs616639 -- 65,342,101(-) tTTTT(G/T)gttgc intron-variant
rs620888 -- 65,351,500(-) ATATT(A/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPF2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
nsv832190 CNV Loss 17160897
esv2422285 CNV Deletion 17116639
dgv1175n71 CNV Loss 21882294
nsv825950 CNV Gain 20364138

Relevant External Links for DPF2 Gene

HapMap Linkage Disequilibrium report

Disorders for DPF2 Gene

(1) MalaCards Diseases for DPF2 Gene

Search for DPF2 Gene in MalaCards »
genes like me logo Genes that share disorders with DPF2: view

No data available for UniProtKB/Swiss-Prot for DPF2 Gene

Publications for DPF2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Crystal structure of the Cys2His2-type zinc finger domain of human DPF2. (PMID: 21888896) Zhang W. … Qi C. (Biochem. Biophys. Res. Commun. 2011) 3 4
  3. The d4 gene family in the human genome. (PMID: 8812431) Chestkov A.V. … Buchman V.L. (Genomics 1996) 3 4
  4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru S.C. … Chandrasekharappa S.C. (Genome Res. 1997) 3 4
  5. Expression and chromosomal localization of the Requiem gene. (PMID: 9680388) Gabig T.G. … Weber G. (Mamm. Genome 1998) 3 4

Products for DPF2 Gene

  • Addgene plasmids for DPF2

Sources for DPF2 Gene

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