Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DPF1 Gene

Aliases for DPF1 Gene

  • D4, Zinc And Double PHD Fingers Family 1 2 3 4
  • NEUD4 3 4 6
  • BRG1-Associated Factor 45B 3 4
  • BAF45b 3 4
  • Zinc Finger Protein Neuro-D4 3
  • Neuro-D4 Homolog 3
  • Neuro-D4 3

External Ids for DPF1 Gene

Previous GeneCards Identifiers for DPF1 Gene

  • GC19M039093
  • GC19M043378
  • GC19M043394
  • GC19M038701
  • GC19M035150

Summaries for DPF1 Gene

GeneCards Summary for DPF1 Gene

DPF1 (D4, Zinc And Double PHD Fingers Family 1) is a Protein Coding gene. An important paralog of this gene is DPF2.

UniProtKB/Swiss-Prot for DPF1 Gene

  • May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPF1 Gene

Genomics for DPF1 Gene

Regulatory Elements for DPF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DPF1 Gene

Start:
38,211,006 bp from pter
End:
38,229,714 bp from pter
Size:
18,709 bases
Orientation:
Minus strand

Genomic View for DPF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPF1 Gene

Proteins for DPF1 Gene

  • Protein details for DPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92782-DPF1_HUMAN
    Recommended name:
    Zinc finger protein neuro-d4
    Protein Accession:
    Q92782
    Secondary Accessions:
    • B3KSY8
    • Q08AJ0

    Protein attributes for DPF1 Gene

    Size:
    380 amino acids
    Molecular mass:
    42502 Da
    Quaternary structure:
    • Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.
    SequenceCaution:
    • Sequence=AAC50685.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI25154.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW56763.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DPF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPF1 Gene

Proteomics data for DPF1 Gene at MOPED

Post-translational modifications for DPF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DPF1 Gene

Domains for DPF1 Gene

Gene Families for DPF1 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

Graphical View of Domain Structure for InterPro Entry

Q92782

UniProtKB/Swiss-Prot:

DPF1_HUMAN :
  • Q92782
Family:
  • Belongs to the requiem/DPF family.
Similarity:
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with DPF1: view

Function for DPF1 Gene

Molecular function for DPF1 Gene

UniProtKB/Swiss-Prot Function: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Gene Ontology (GO) - Molecular Function for DPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with DPF1: view
genes like me logo Genes that share phenotypes with DPF1: view

Animal Model Products

CRISPR Products

miRNA for DPF1 Gene

miRTarBase miRNAs that target DPF1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPF1 Gene

Localization for DPF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPF1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPF1 Gene COMPARTMENTS Subcellular localization image for DPF1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0071565 nBAF complex ISS --
genes like me logo Genes that share ontologies with DPF1: view

Pathways for DPF1 Gene

SuperPathways for DPF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS 8812431
GO:0007399 nervous system development ISS --
genes like me logo Genes that share ontologies with DPF1: view

No data available for Pathways by source for DPF1 Gene

Transcripts for DPF1 Gene

Unigene Clusters for DPF1 Gene

D4, zinc and double PHD fingers family 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPF1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DPF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for DPF1 Gene

GeneLoc Exon Structure for
DPF1
ECgene alternative splicing isoforms for
DPF1

Expression for DPF1 Gene

mRNA expression in normal human tissues for DPF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPF1 Gene

This gene is overexpressed in Brain - Cortex (8.1), Brain - Frontal Cortex (BA9) (6.3), Brain - Anterior cingulate cortex (BA24) (6.0), Brain - Nucleus accumbens (basal ganglia) (4.6), and Brain - Hippocampus (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DPF1 Gene

SOURCE GeneReport for Unigene cluster for DPF1 Gene Hs.631576

genes like me logo Genes that share expressions with DPF1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DPF1 Gene

Orthologs for DPF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPF1 35
  • 99.32 (n)
  • 99.42 (a)
DPF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPF1 35
  • 94.92 (n)
  • 99.22 (a)
DPF1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPF1 35
  • 92.59 (n)
  • 95.35 (a)
DPF1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpf1 35
  • 92.59 (n)
  • 97.93 (a)
Dpf1 16
Dpf1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpf1 35
  • 92.76 (n)
  • 98.45 (a)
lizard
(Anolis carolinensis)
Reptilia DPF1 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15372 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dpf1 35
  • 74.61 (n)
  • 85.86 (a)
zebrafish
(Danio rerio)
Actinopterygii dpf1 36
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta d4 36
  • 30 (a)
ManyToMany
tth 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dpff-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for DPF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPF1 Gene

ENSEMBL:
Gene Tree for DPF1 (if available)
TreeFam:
Gene Tree for DPF1 (if available)

Paralogs for DPF1 Gene

Paralogs for DPF1 Gene

Selected SIMAP similar genes for DPF1 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with DPF1: view

Variants for DPF1 Gene

Sequence variations from dbSNP and Humsavar for DPF1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1865066 -- 38,216,657(+) TCCTG(G/T)CCTCC intron-variant
rs2255456 -- 38,218,928(+) GGGCC(C/T)ACCTG intron-variant
rs2278430 -- 38,216,037(+) TGCTC(C/G)GGGTC intron-variant
rs2278431 -- 38,216,349(+) CATCC(A/G)TACCT intron-variant
rs2278433 -- 38,222,862(+) GACCC(A/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPF1 Gene

Variant ID Type Subtype PubMed ID
nsv833821 CNV Loss 17160897
nsv911657 CNV Loss 21882294

Relevant External Links for DPF1 Gene

HapMap Linkage Disequilibrium report
DPF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPF1 Gene

Disorders for DPF1 Gene

Relevant External Links for DPF1

Genetic Association Database (GAD)
DPF1
genes like me logo Genes that share disorders with DPF1: view

No data available for UniProtKB/Swiss-Prot for DPF1 Gene

Publications for DPF1 Gene

  1. The d4 gene family in the human genome. (PMID: 8812431) Chestkov A.V. … Buchman V.L. (Genomics 1996) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1. (PMID: 20400511) Matsuyama R. … Kato S. (J. Biol. Chem. 2010) 3
  5. Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-I_B RelA/p50 heterodimer. (PMID: 22334708) Ishizaka A. … Iba H. (J. Biol. Chem. 2012) 3

Products for DPF1 Gene

Sources for DPF1 Gene

Back to Top

Content