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Aliases for DPF1 Gene

Aliases for DPF1 Gene

  • Double PHD Fingers 1 2 3 5
  • D4, Zinc And Double PHD Fingers Family 1 2 3 4
  • BRG1-Associated Factor 45B 3 4
  • BAF45b 3 4
  • NEUD4 3 4
  • Zinc Finger Protein Neuro-D4 3
  • Neuro-D4 Homolog 3
  • Neuro-D4 3

External Ids for DPF1 Gene

Previous GeneCards Identifiers for DPF1 Gene

  • GC19M039093
  • GC19M043378
  • GC19M043394
  • GC19M038701
  • GC19M035150

Summaries for DPF1 Gene

GeneCards Summary for DPF1 Gene

DPF1 (Double PHD Fingers 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is DPF2.

UniProtKB/Swiss-Prot for DPF1 Gene

  • May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Additional gene information for DPF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPF1 Gene

Genomics for DPF1 Gene

Regulatory Elements for DPF1 Gene

Enhancers for DPF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H038673 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12 -465.2 -465173 41 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 ZC3H11A MEF2D HNRNPL ZNF573 ACTN4 CATSPERG PAF1 ZNF607 ENSG00000266963 ENSG00000269688 CAPN12 SUPT5H
GH19H038299 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -73.2 -73232 6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZBTB7B TCF12 ZNF121 ZNF766 GLIS2 C19orf33 ZNF781 ZNF540 ZNF527 ZFP30 ZNF571 ZNF793 ENSG00000267152 CATSPERG DPF1
GH19H038647 1.8 FANTOM5 ENCODE dbSUPER 12 -430.1 -430079 25 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 SP3 ZC3H11A NFYC ZFP41 HNRNPL ZFP30 ZNF781 ZNF573 ZNF607 ENSG00000267152 SUPT5H PAK4 PAF1 PLEKHG2
GH19H039073 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 -844.2 -844230 1 ZNF493 SIN3A ZNF2 ZNF121 GLIS2 FOS ATF7 SP3 YY2 REST ZNF780B HNRNPL SUPT5H EID2B PAF1 ZNF546 ENSG00000266963 PAK4 FBL MED29
GH19H038269 1.5 Ensembl ENCODE dbSUPER 11.4 -41.0 -40991 1 ATF1 ARNT SIN3A FEZF1 ZNF2 TCF12 ZNF121 GLIS2 GATA2 KLF7 CATSPERG C19orf33 HNRNPL ENSG00000266963 HKR1 ZNF607 ENSG00000269445 ENSG00000267375 ENSG00000269172 ZNF793
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DPF1 on UCSC Golden Path with GeneCards custom track

Promoters for DPF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109248 114 401 RB1 INSM2 ZNF76 DEAF1 SIN3A ETS1 GLIS2 ZNF143 RCOR1 FOS
ENSR00000288294 1014 201 PKNOX1 ZNF76 KLF17 ZNF366 ZEB2 ZNF398 ZNF843 ZFP69B ZNF148 KLF16

Genomic Location for DPF1 Gene

Chromosome:
19
Start:
38,211,006 bp from pter
End:
38,229,714 bp from pter
Size:
18,709 bases
Orientation:
Minus strand

Genomic View for DPF1 Gene

Genes around DPF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPF1 Gene

Proteins for DPF1 Gene

  • Protein details for DPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92782-DPF1_HUMAN
    Recommended name:
    Zinc finger protein neuro-d4
    Protein Accession:
    Q92782
    Secondary Accessions:
    • B3KSY8
    • Q08AJ0

    Protein attributes for DPF1 Gene

    Size:
    380 amino acids
    Molecular mass:
    42502 Da
    Quaternary structure:
    • Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.
    SequenceCaution:
    • Sequence=AAC50685.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI25154.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW56763.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DPF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPF1 Gene

Post-translational modifications for DPF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DPF1 Gene

Domains & Families for DPF1 Gene

Gene Families for DPF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q92782

UniProtKB/Swiss-Prot:

DPF1_HUMAN :
  • Belongs to the requiem/DPF family.
Family:
  • Belongs to the requiem/DPF family.
genes like me logo Genes that share domains with DPF1: view

Function for DPF1 Gene

Molecular function for DPF1 Gene

UniProtKB/Swiss-Prot Function:
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Phenotypes From GWAS Catalog for DPF1 Gene

Gene Ontology (GO) - Molecular Function for DPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DPF1: view
genes like me logo Genes that share phenotypes with DPF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPF1 Gene

Localization for DPF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPF1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DPF1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0071565 nBAF complex ISS --
genes like me logo Genes that share ontologies with DPF1: view

Pathways & Interactions for DPF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process TAS 8812431
GO:0007399 nervous system development ISS --
genes like me logo Genes that share ontologies with DPF1: view

No data available for Pathways by source and SIGNOR curated interactions for DPF1 Gene

Drugs & Compounds for DPF1 Gene

No Compound Related Data Available

Transcripts for DPF1 Gene

Unigene Clusters for DPF1 Gene

D4, zinc and double PHD fingers family 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for DPF1 Gene

GeneLoc Exon Structure for
DPF1
ECgene alternative splicing isoforms for
DPF1

Expression for DPF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DPF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPF1 Gene

This gene is overexpressed in Brain - Cortex (x8.1), Brain - Frontal Cortex (BA9) (x6.3), Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Nucleus accumbens (basal ganglia) (x4.6), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for DPF1 Gene

This gene is overexpressed in Fetal Brain (67.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DPF1 Gene



Protein tissue co-expression partners for DPF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DPF1 Gene:

DPF1

SOURCE GeneReport for Unigene cluster for DPF1 Gene:

Hs.631576

Evidence on tissue expression from TISSUES for DPF1 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with DPF1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DPF1 Gene

Orthologs for DPF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPF1 33 34
  • 99.32 (n)
cow
(Bos Taurus)
Mammalia DPF1 33 34
  • 94.92 (n)
rat
(Rattus norvegicus)
Mammalia Dpf1 33
  • 92.76 (n)
dog
(Canis familiaris)
Mammalia DPF1 33 34
  • 92.59 (n)
mouse
(Mus musculus)
Mammalia Dpf1 33 16 34
  • 92.59 (n)
lizard
(Anolis carolinensis)
Reptilia DPF1 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpf1 33
  • 74.61 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15372 33
zebrafish
(Danio rerio)
Actinopterygii dpf1 34
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta d4 34
  • 30 (a)
ManyToMany
tth 34
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dpff-1 34
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for DPF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPF1 Gene

ENSEMBL:
Gene Tree for DPF1 (if available)
TreeFam:
Gene Tree for DPF1 (if available)

Paralogs for DPF1 Gene

Paralogs for DPF1 Gene

genes like me logo Genes that share paralogs with DPF1: view

Variants for DPF1 Gene

Sequence variations from dbSNP and Humsavar for DPF1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000060673 -- 38,223,813(+) AGGCC(C/T)CCGCA intron-variant, utr-variant-5-prime
rs1000127529 -- 38,228,478(+) GGGGA(A/G)GTCGC intron-variant
rs1000158500 -- 38,210,532(+) ATACC(C/T)TCCTG downstream-variant-500B
rs1000431775 -- 38,223,490(+) CCACA(C/G)AGACA intron-variant
rs1000515808 -- 38,221,642(+) CACTA(C/T)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPF1 Gene

Variant ID Type Subtype PubMed ID
nsv1071932 CNV deletion 25765185
nsv1072349 CNV deletion 25765185
nsv1136284 CNV deletion 24896259
nsv833821 CNV loss 17160897

Variation tolerance for DPF1 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPF1 Gene

Disorders for DPF1 Gene

Relevant External Links for DPF1

Genetic Association Database (GAD)
DPF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPF1

No disorders were found for DPF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPF1 Gene

Publications for DPF1 Gene

  1. The d4 gene family in the human genome. (PMID: 8812431) Chestkov AV … Buchman VL (Genomics 1996) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Agonist-specific protein interactomes of glucocorticoid and androgen receptor as revealed by proximity mapping. (PMID: 28611094) Lempiäinen JK … Palvimo JJ (Molecular & cellular proteomics : MCP 2017) 3 60

Products for DPF1 Gene

Sources for DPF1 Gene

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