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DPF1 Gene

protein-coding   GIFtS: 50
GCID: GC19M038701

D4, Zinc And Double PHD Fingers Family 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
D4, Zinc And Double PHD Fingers Family 11 2 3     neuro-d42
NEUD42 3 5     Neuro-D4 Homolog2
BRG1-Associated Factor 45B2 3     Zinc Finger Protein Neuro-D42
BAF45b2     BAF45B3

External Ids:    HGNC: 202251   Entrez Gene: 81932   Ensembl: ENSG000000113327   OMIM: 6016705   UniProtKB: Q927823   

Export aliases for DPF1 gene to outside databases

Previous GC identifers: GC19M039093 GC19M043378 GC19M043394 GC19M035150


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DPF1 Gene:
DPF1 (D4, zinc and double PHD fingers family 1) is a protein-coding gene. Diseases associated with DPF1 include spina bifida, and sinusitis. An important paralog of this gene is DPF3.

UniProtKB/Swiss-Prot: DPF1_HUMAN, Q92782
Function: May have an important role in developing neurons by participating in regulation of cell survival,
possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex
(nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling
mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from
proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of
the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes
which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and
DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the
self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays
a role regulating the activity of genes essential for dendrite growth (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPF1 gene promoter:
         E2F-3a   SRF   E2F-1   E2F   AP-1   SRF (504 AA)   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): DPF1 promoter sequence
   Search Chromatin IP Primers for DPF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.12

DPF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPF1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M038701:  view genomic region     (about GC identifiers)

Start:
38,701,646 bp from pter      End:
38,720,354 bp from pter
Size:
18,709 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPF1_HUMAN, Q92782 (See protein sequence)
Recommended Name: Zinc finger protein neuro-d4  
Size: 380 amino acids; 42502 Da
Subunit: Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least,
ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A,
SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin
(By similarity)
Caution: It is uncertain whether Met-1 or Met-28 is the initiator
Sequence caution: Sequence=AAC50685.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI25154.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW56763.1;
Type=Erroneous gene model prediction;
Secondary accessions: B3KSY8 Q08AJ0
Alternative splicing: 3 isoforms:  Q92782-1   Q92782-2   Q92782-3   

Explore the universe of human proteins at neXtProt for DPF1: NX_Q92782

Explore proteomics data for DPF1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DPF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128627.1  NP_001128628.1  NP_001276907.1  NP_004638.2  

    ENSEMBL proteins: 
     ENSP00000397354   ENSP00000390223   ENSP00000408201   ENSP00000391884   ENSP00000347716  
     ENSP00000411569   ENSP00000416347   ENSP00000399015   ENSP00000465123   ENSP00000412098  

    DPF1 Human Recombinant Protein Products:

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    Novus Biologicals DPF1 Lysate
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    Cloud-Clone Corp. Proteins for DPF1

    DPF1 Antibody Products:

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    DPF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for DPF1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PHF: Zinc fingers, PHD-type

    Selected InterPro protein domains (see all 6):
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR025750 Requiem/DPF_N_dom
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q92782

    ProtoNet protein and cluster: Q92782

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: DPF1_HUMAN, Q92782
    Similarity: Belongs to the requiem/DPF family
    Similarity: Contains 2 PHD-type zinc fingers


    DPF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPF1_HUMAN, Q92782
    Function: May have an important role in developing neurons by participating in regulation of cell survival,
    possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex
    (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling
    mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from
    proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of
    the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes
    which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and
    DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the
    self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays
    a role regulating the activity of genes essential for dendrite growth (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    DPF1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DPF1:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPF1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPF1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPF1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DPF1:
    hsa-mir-27b-3p (MIRT046214), hsa-mir-18a-3p (MIRT040773), hsa-mir-212-3p (MIRT047000)

    Block miRNA regulation of human, mouse, rat DPF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPF1 (see all 28):
    hsa-miR-3149 hsa-miR-495 hsa-miR-29a hsa-miR-29c hsa-miR-1908 hsa-miR-218 hsa-miR-374c hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidDPF1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DPF1
    Predesigned siRNA for gene silencing in human, mouse, rat DPF1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DPF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DPF1 (NM_004647)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DPF1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DPF1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPF1_HUMAN, Q92782: Cytoplasm (Potential). Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0071565nBAF complex ISS--

    DPF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPF1
    Interactions:

        Search GeneGlobe Interaction Network for DPF1

    3 Interacting proteins for DPF1 (Q927822, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPN1P048433I2D: score=3 
    ESRRAP114743I2D: score=1 
    --Q9WMX22MINT-7048243
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006915apoptotic process TAS8812431
    GO:0007399nervous system development ISS--

    DPF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DPF1 gene (4 alternative transcripts): 
    NM_001135155.2  NM_001135156.2  NM_001289978.1  NM_004647.3  

    Unigene Cluster for DPF1:

    D4, zinc and double PHD fingers family 1
    Hs.631576  [show with all ESTs]
    Unigene Representative Sequence: NM_001135155
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000420980(uc002ohl.3) ENST00000416611 ENST00000418517 ENST00000414789
    ENST00000355526 ENST00000473716 ENST00000456296 ENST00000472656 ENST00000471976
    ENST00000494031 ENST00000488378 ENST00000438060 ENST00000475938(uc010xtw.1)
    ENST00000438365 ENST00000586624 ENST00000412732(uc002ohn.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DPF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DPF1 (see all 28):
    hsa-miR-3149 hsa-miR-495 hsa-miR-29a hsa-miR-29c hsa-miR-1908 hsa-miR-218 hsa-miR-374c hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidDPF1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DPF1
    Predesigned siRNA for gene silencing in human, mouse, rat DPF1
    Clone
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    OriGene clones in human, mouse for DPF1 (see all 20)
    OriGene ORF clones in mouse, rat for DPF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DPF1 (NM_004647)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPF1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DPF1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPF1
      QuantiTect SYBR Green Assays in human, mouse, rat DPF1
      QuantiFast Probe-based Assays in human, mouse, rat DPF1

    Additional mRNA sequence: 

    AK094632.1 AK127198.1 AK297581.1 AK308563.1 BC021191.2 BC125152.1 BC125153.1 GQ358728.1 
    U43843.1 

    10 DOTS entries:

    DT.100762846  DT.91899063  DT.100022554  DT.101956424  DT.100777210  DT.92448472  DT.121505348  DT.95252336 
    DT.97766711  DT.95289537 

    Selected AceView cDNA sequences (see all 64):

    BU736337 CR604718 BF982601 BU157197 AI754148 CR614366 AK094632 BU176742 
    BE392893 BF970565 BG056460 BM710727 BX117254 AL538568 BI917298 BE857212 
    BM921496 BC021191 AI360978 AI857563 BX394192 BG775271 BG702835 BX461049 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DPF1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                                                              -                     
    SP2:                    -                                                               
    SP3:                                                  -           -                     
    SP4:                                                                                    


    ECgene alternative splicing isoforms for DPF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGAGCCT
    DPF1 Expression
    About this image


    DPF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Bone (Muscoskeletal System)
             Zeugopod Epiphyseal End
    DPF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631576
        Custom PCR Arrays for DPF1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPF1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpf11 , 5 D4, zinc and double PHD fingers family 11, 5 92.59(n)1
    97.93(a)1
      7 (16.94 cM)5
    298611  NM_013874.21  NP_038902.11 
     293039515 
    lizard
    (Anolis carolinensis)
    Reptilia DPF16
    D4, zinc and double PHD fingers family 1
    90(a)
    1 ↔ 1
    LGf(2599562-2639374)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.153722 Xenopus laevis transcribed sequence with moderate similarity more 77.21(n)    BJ039474.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dpf16
    D4, zinc and double PHD fingers family 1
    80(a)
    1 ↔ 1
    15(13822097-13940436) ENSDARG00000053548
    fruit fly
    (Drosophila melanogaster)
    Insecta d46
    tth6
    toothrin
    30(a)
    15(a)
    many ↔ many
    many ↔ many
    2R(1147484-1183475)
    X(13507226-13510436)
    worm
    (Caenorhabditis elegans)
    Secernentea dpff-16
    Protein DPFF-1, isoform b (dpff-1) mRNA, complete ...
    32(a)
    1 → many
    III(5903574-5906122) WBGene00016200


    ENSEMBL Gene Tree for DPF1 (if available)
    TreeFam Gene Tree for DPF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPF1 gene
    DPF32  PHF102  DPF22  
    3 SIMAP similar genes for DPF1 using alignment to 10 protein entries:     DPF1_HUMAN (see all proteins):
    DPF3    DPF2    AIRE

    DPF1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPF1 (see all 445)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs736276991,2
    C--38701192(+) AGCGCC/TTCTCT 3 -- int11Minor allele frequency- T:0.50WA 2
    rs1878851451,2
    --38701195(+) GCCTCC/TCTTTC 3 -- int10--------
    rs1507940791,2
    --38701415(+) TGCCAA/GGGCAA 3 -- int10--------
    rs1128961721,2
    C--38701562(+) CTGGCC/TGGTCG 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs2021603111,2
    C--38701827(-) TGTTTG/TTTGTT 3 -- ut310--------
    rs1167961971,2
    F--38702037(+) GGGGCG/AGGCAC 3 -- ut311Minor allele frequency- A:0.16WA 118
    rs81108641,2
    C--38702243(+) ggggcC/TggcAG 3 -- ut31 ese32Minor allele frequency- T:0.00NA 4
    rs1390549221,2
    --38702495(+) GAGAGA/GGAGGG 3 -- ut310--------
    rs2001355391,2
    C--38702687(+) GTCGCA/GGCGAG 3 -- ut310--------
    rs2011501021,2
    C--38702695(+) GAGCCG/TAGCCG 3 -- ut311Minor allele frequency- T:0.00EU 545

    HapMap Linkage Disequilibrium report for DPF1 (38701646 - 38720354 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DPF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911657CNV Loss21882294
    nsv833821CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601670    OMIM disorders: --

    6 diseases for DPF1:    
    About MalaCards
    spina bifida    sinusitis    neuronitis    cerebritis
    prostate cancer    prostatitis


    DPF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DPF1

    Export disorders for DPF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPF1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DPF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The d4 gene family in the human genome. (PubMed id 8812431)1, 2, 3 Chestkov A.V.... Buchman V.L. (Genomics 1996)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Double plant homeodomain (PHD) finger proteins DPF3a and -3b are required as transcriptional co-activators in SWI/SNF complex-dependent activation of NF-I_B RelA/p50 heterodimer. (PubMed id 22334708)1 Ishizaka A....Iba H. (J. Biol. Chem. 2012)
    5. Double PHD fingers protein DPF2 recognizes acetylated histones and suppresses the function of estrogen-related receptor alpha through histone deacetylase 1. (PubMed id 20400511)1 Matsuyama R....Kato S. (J. Biol. Chem. 2010)
    6. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. (PubMed id 19767754)4 Gudmundsson J....Stefansson K. (Nat. Genet. 2009)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8193 HGNC: 20225 AceView: DPF1 Ensembl:ENSG00000011332 euGenes: HUgn8193
    ECgene: DPF1 H-InvDB: DPF1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DPF1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DPF1 gene:
    Search GeneIP for patents involving DPF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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