DPEP3 Gene
protein-coding GIFtS: 48
GCID: GC16M068009
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dipeptidase 3
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Aliases for DPEP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Dipeptidase 31 2 | | EC 3.4.13.193 8 | | MBD32 5 | | Membrane-Bound Dipeptidase 32 | | Metallopeptidase (Family M19)2 |
Export aliases for DPEP3 gene to outside databasesPrevious GC identifers: GC16M067745 GC16M067785 GC16M066567 GC16M053885 |
Summaries for DPEP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DPEP3: This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism ofvarious dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in acluster with another member of this family. Alternatively spliced transcript variants that encode different isoformshave been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DPEP3_HUMAN, Q9H4B8Function: Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity) Gene Wiki entry for DPEP3
|
Genomic Views for DPEP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DPEP3 gene promoter: AP-1 p53 RREB-1 AP-4 YY1 Roaz GATA-1 GATA-2 AREB6 Other transcription factors
Search SABiosciences Chromatin IP Primers for DPEP3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPEP3 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1DPEP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M068009: view genomic region
(about GC identifiers)
Start:
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68,009,566 bp from pter |
End:
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68,014,732 bp from pter |
Size:
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5,167 bases |
Orientation:
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minus strand |
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Proteins for DPEP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DPEP3_HUMAN, Q9H4B8 (See
protein sequence)Recommended Name: Dipeptidase 3 precursor Size: 488 amino acids; 53687 Da
Cofactor: Zinc (By similarity)
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Membrane; Lipid-anchor, GPI-anchor (By similarity)
Sequence caution: Sequence=AAH57789.1; Type=Erroneous initiation; Sequence=BAG51910.1; Type=Erroneous initiation;Sequence=CAC15385.1; Type=Erroneous initiation; Sequence=EAW83198.1; Type=Erroneous initiation;
Secondary accessions: B3KQ48 Q6PEZ5 Q6UXE4Explore the universe of human proteins at neXtProt for DPEP3: NX_Q9H4B8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H4B8 4/7 DME Specific Peptides for DPEP3 (Q9H4B8) (see all 7)
DPEP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123230.1 NP_071752.3 ENSEMBL proteins: ENSP00000268793 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005624 | membrane fraction |
-- | -- | | GO:0031225 | anchored to membrane |
IEA | -- |
DPEP3 for ontologies About GeneDecksing
DPEP3 Antibody Products: Assay Products for DPEP3: |
Protein
Domains / Families for DPEP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPEP3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H4B8ProtoNet protein and cluster: Q9H4B8 1 Blocks protein family: IPB000180 Renal dipeptidase
UniProtKB/Swiss-Prot: DPEP3_HUMAN, Q9H4B8Similarity: Belongs to the peptidase M19 family |
Function for DPEP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DPEP3_HUMAN, Q9H4B8Function: Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity)Catalytic activity: Hydrolysis of dipeptidesEnzyme regulation: Inhibited by L-penicillamine (By similarity)Enzyme Number (IUBMB): EC 3.4.13.191 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPEP3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPEP3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DPEP3 (NM_022357) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPEP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPEP3  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPEP3 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
DPEP3 for ontologies About GeneDecksing
Animal Models: Mouse knock-out Dpep3tm1Lex for DPEP3 1 MGI phenotypic allele for Dpep3 (no phenotypes)
DPEP3 for phenotypes About GeneDecksing
|
Pathways & Interactions for DPEP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Busulfan Pathway, Pharmacodynamics | |
1 PharmGKB Pathway for DPEP3 Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPEP3
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 1 Interacting protein for DPEP3 (ENSP000002687934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
DPEP3 for ontologies About GeneDecksing
|
Drugs & Compounds for DPEP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for DPEP3 available from Tocris Bioscience About this table
1 HMDB Compound for DPEP3 About this table Search CenterWatch for drugs/clinical trials and news about DPEP3 
|
Transcripts for DPEP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DPEP3 gene (2 alternative transcripts): NM_001129758.1 NM_022357.3 Unigene Cluster for DPEP3: Dipeptidase 3 Hs.302028 [show with all ESTs]Unigene Representative Sequence: NM_0223572 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000268793(uc010cex.3 uc002evc.4) ENST00000574342
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPEP3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPEP3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DPEP3 (NM_022357) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPEP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPEP3  |
Additional cDNA sequence: AJ291679.1 AK057401.1 AY358390.1 BC037243.1 BC057789.1 2 DOTS entries: DT.301532 DT.101978736 24/98 AceView cDNA sequences (see all 98): NM_022357 AI969764 CB528462 BI909651 AW450595 BI836036 BE670487 AY358454 BE669521 AJ291679 CA308968 AI887572 BC037243 CA418626 CR625664 CA309354 AK057401 BE327272 AA404265 AA937963 AI524102 AK092884 AI867862 BI911849 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for DPEP3 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for DPEP3
|
Expression for DPEP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPEP3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGGGTGCTGC
About this image See DPEP3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DPEP3
SOURCE GeneReport for Unigene cluster: Hs.302028 SABiosciences Custom PCR Arrays for DPEP3
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPEP3 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPEP3 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPEP3 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPEP3 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPEP3 |
Orthologs for DPEP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes and Archea.
Orthologs for DPEP3 gene from 18 species (see representative species ) About this table
Species with no ortholog for DPEP3
ENSEMBL Gene Tree for DPEP3 (if available) TreeFam Gene Tree for DPEP3 (if available)  |
Paralogs for DPEP3 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for DPEP3 gene
- DPEP22 DPEP12
2 SIMAP similar genes for DPEP3 using alignment to 1 protein entry: DPEP3_HUMAN:DPEP2 DPEP1
DPEP3 for paralogs About GeneDecksing
|
Genomic Variants for DPEP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 16 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DPEP3 (68009566 - 68014732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DPEP3: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPEP3 |
|
Disorders
/ Diseases for DPEP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPEP3 for disorders About MalaCards
DPEP3 for disorders About GeneDecksing
OMIM gene information: 609926
OMIM disorders: --
Export disorders for DPEP3 gene to outside databases
|
Publications for DPEP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPEP3 gene integrated from 9 sources: (articles sorted by number of sources associating them with DPEP3) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The Brd4 extraterminal domain confers transcription a ctivation independent of pTEFb by recruiting multiple proteins, including NSD3. (PubMed id 21555454)1 Rahman S....Howley P.M. (2011)
- Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PubMed id 19060910)1 Sabatti C....Peltonen L. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- Identification of two additional members of the membr ane-bound dipeptidase family. (PubMed id 12738806)1 Habib G.M....Lieberman M.W. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for DPEP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DPEP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DPEP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DPEP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DPEP3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DPEP3 gene: Search GeneIP for patents involving DPEP3
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DPEP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for DPEP3 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPEP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPEP3 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for DPEP3 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPEP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPEP3 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for DPEP3 | | OriGene Custom Protein Services for DPEP3 | | OriGene Custom Immunoassay Development | | |
| |  |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPEP3 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPEP3 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPEP3 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPEP3 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPEP3 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPEP3 |
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 |  |  |  | |
| | | Tocris compounds for DPEP3 |
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 | | DPEP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPEP3 |
|  |  |  | | | ThermoFisher Antibodies for DPEP3 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPEP3 |
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