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Aliases for DPEP3 Gene

Aliases for DPEP3 Gene

  • Dipeptidase 3 2 3
  • EC 3.4.13.19 4 64
  • MBD3 3 6
  • Metallopeptidase (Family M19) 3
  • Membrane-Bound Dipeptidase 3 3

External Ids for DPEP3 Gene

Summaries for DPEP3 Gene

Entrez Gene Summary for DPEP3 Gene

  • This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPEP3 Gene

DPEP3 (Dipeptidase 3) is a Protein Coding gene. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Gene Expression. GO annotations related to this gene include metalloexopeptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is DPEP1.

UniProtKB/Swiss-Prot for DPEP3 Gene

  • Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).

Gene Wiki entry for DPEP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP3 Gene

Genomics for DPEP3 Gene

Genomic Location for DPEP3 Gene

Start:
67,975,663 bp from pter
End:
67,980,829 bp from pter
Size:
5,167 bases
Orientation:
Minus strand

Genomic View for DPEP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPEP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP3 Gene

Regulatory Elements for DPEP3 Gene

Proteins for DPEP3 Gene

  • Protein details for DPEP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4B8-DPEP3_HUMAN
    Recommended name:
    Dipeptidase 3
    Protein Accession:
    Q9H4B8
    Secondary Accessions:
    • B3KQ48
    • Q6PEZ5
    • Q6UXE4

    Protein attributes for DPEP3 Gene

    Size:
    488 amino acids
    Molecular mass:
    53687 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAH57789.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC15385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83198.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DPEP3 Gene

Proteomics data for DPEP3 Gene at MOPED

Post-translational modifications for DPEP3 Gene

Other Protein References for DPEP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DPEP3 Gene

Protein Domains for DPEP3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

DPEP3_HUMAN
Family:
  • Belongs to the peptidase M19 family.:
    • Q9H4B8
genes like me logo Genes that share domains with DPEP3: view

No data available for Gene Families for DPEP3 Gene

Function for DPEP3 Gene

Molecular function for DPEP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function: Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).

Enzyme Numbers (IUBMB) for DPEP3 Gene

Gene Ontology (GO) - Molecular Function for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008233 peptidase activity --
GO:0008235 metalloexopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with DPEP3: view

miRNA for DPEP3 Gene

miRTarBase miRNAs that target DPEP3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPEP3 Gene

Localization for DPEP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP3 Gene

Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPEP3 Gene COMPARTMENTS Subcellular localization image for DPEP3 gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with DPEP3: view

Pathways for DPEP3 Gene

genes like me logo Genes that share pathways with DPEP3: view

Pathways by source for DPEP3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for DPEP3 Gene
1 Qiagen pathway for DPEP3 Gene
1 Cell Signaling Technology pathway for DPEP3 Gene

Interacting Proteins for DPEP3 Gene

Gene Ontology (GO) - Biological Process for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007140 male meiosis ISS --
genes like me logo Genes that share ontologies with DPEP3: view

Compounds for DPEP3 Gene

(1) HMDB Compounds for DPEP3 Gene

Compound Synonyms Cas Number PubMed IDs
10,11-Dihydro-12R-hydroxy-leukotriene E4
  • 5,12-dihydroxy-6-cysteinyl-7,9,14-eicosatrienoate
Not Available
genes like me logo Genes that share compounds with DPEP3: view

Transcripts for DPEP3 Gene

mRNA/cDNA for DPEP3 Gene

Unigene Clusters for DPEP3 Gene

Dipeptidase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:

Relevant External Links for DPEP3 Gene

GeneLoc Exon Structure for
DPEP3
ECgene alternative splicing isoforms for
DPEP3

Expression for DPEP3 Gene

mRNA expression in normal human tissues for DPEP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP3 Gene

This gene is overexpressed in Testis (39.8) and Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DPEP3 Gene

SOURCE GeneReport for Unigene cluster for DPEP3 Gene Hs.302028

genes like me logo Genes that share expressions with DPEP3: view

Orthologs for DPEP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPEP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPEP3 36
  • 97.86 (n)
  • 97.66 (a)
DPEP3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPEP3 36
  • 81.07 (n)
  • 73.5 (a)
DPEP3 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPEP3 36
  • 85.16 (n)
  • 81.43 (a)
DPEP3 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpep3 36
  • 79.58 (n)
  • 74.83 (a)
Dpep3 16
Dpep3 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dpep3 36
  • 80.18 (n)
  • 75.28 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DPEP3 37
  • 49 (a)
OneToMany
LOC100534995 36
  • 57.52 (n)
  • 56.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34420 36
  • 52.84 (n)
  • 47.65 (a)
CG34420 37
  • 21 (a)
ManyToMany
CG42750 37
  • 16 (a)
ManyToMany
CG5282 37
  • 23 (a)
ManyToMany
CG6154 37
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
Species with no ortholog for DPEP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP3 Gene

ENSEMBL:
Gene Tree for DPEP3 (if available)
TreeFam:
Gene Tree for DPEP3 (if available)

Paralogs for DPEP3 Gene

Paralogs for DPEP3 Gene

Selected SIMAP similar genes for DPEP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPEP3: view

Variants for DPEP3 Gene

Sequence variations from dbSNP and Humsavar for DPEP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs255048 -- 67,978,946(+) ACTAC(C/T)GAGCC intron-variant
rs255049 -- 67,979,568(+) CTGGC(C/T)GACCC intron-variant
rs255056 -- 67,982,282(+) gagag(C/G)cgtgg upstream-variant-2KB
rs2271296 -- 67,977,157(+) TGGGT(C/T)GTTGG intron-variant
rs7189697 -- 67,979,656(+) GAGGC(C/T)GTCTC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for DPEP3 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906815 CNV Loss 21882294
nsv906816 CNV Loss 21882294

Relevant External Links for DPEP3 Gene

HapMap Linkage Disequilibrium report
DPEP3

Disorders for DPEP3 Gene

Relevant External Links for DPEP3

Genetic Association Database (GAD)
DPEP3
genes like me logo Genes that share disorders with DPEP3: view

No data available for UniProtKB/Swiss-Prot for DPEP3 Gene

Publications for DPEP3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C. … Peltonen L. (Nat. Genet. 2009) 3 49
  5. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. (PMID: 21555454) Rahman S. … Howley P.M. (Mol. Cell. Biol. 2011) 3

Products for DPEP3 Gene

Sources for DPEP3 Gene

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