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Aliases for DPEP3 Gene

Aliases for DPEP3 Gene

  • Dipeptidase 3 2 3 5
  • EC 3.4.13.19 4 63
  • Testis Secretory Sperm-Binding Protein Li 211a 3
  • Metallopeptidase (Family M19) 3
  • Membrane-Bound Dipeptidase 3 3
  • MBD3 3

External Ids for DPEP3 Gene

Previous GeneCards Identifiers for DPEP3 Gene

  • GC16M067745
  • GC16M067785
  • GC16M066567
  • GC16M068009
  • GC16M053885

Summaries for DPEP3 Gene

Entrez Gene Summary for DPEP3 Gene

  • This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPEP3 Gene

DPEP3 (Dipeptidase 3) is a Protein Coding gene. Among its related pathways are Busulfan Pathway, Pharmacodynamics and Aflatoxin activation and detoxification. GO annotations related to this gene include peptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP2.

UniProtKB/Swiss-Prot for DPEP3 Gene

  • Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).

Gene Wiki entry for DPEP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP3 Gene

Genomics for DPEP3 Gene

Regulatory Elements for DPEP3 Gene

Enhancers for DPEP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPEP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPEP3 Gene

Chromosome:
16
Start:
67,975,663 bp from pter
End:
67,980,829 bp from pter
Size:
5,167 bases
Orientation:
Minus strand

Genomic View for DPEP3 Gene

Genes around DPEP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPEP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPEP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP3 Gene

Proteins for DPEP3 Gene

  • Protein details for DPEP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4B8-DPEP3_HUMAN
    Recommended name:
    Dipeptidase 3
    Protein Accession:
    Q9H4B8
    Secondary Accessions:
    • B3KQ48
    • Q6PEZ5
    • Q6UXE4

    Protein attributes for DPEP3 Gene

    Size:
    488 amino acids
    Molecular mass:
    53687 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAH57789.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51910.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC15385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=EAW83198.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DPEP3 Gene

Proteomics data for DPEP3 Gene at MOPED

Post-translational modifications for DPEP3 Gene

  • Glycosylation at Asn 334
  • Modification sites at PhosphoSitePlus

Other Protein References for DPEP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for DPEP3 Gene

Protein Domains for DPEP3 Gene

Suggested Antigen Peptide Sequences for DPEP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H4B8

UniProtKB/Swiss-Prot:

DPEP3_HUMAN :
  • Belongs to the peptidase M19 family.
Family:
  • Belongs to the peptidase M19 family.
genes like me logo Genes that share domains with DPEP3: view

No data available for Gene Families for DPEP3 Gene

Function for DPEP3 Gene

Molecular function for DPEP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function:
Probable metalloprotease which hydrolyzes cystinyl-bis-glycine. May be involved in meiosis (By similarity).

Enzyme Numbers (IUBMB) for DPEP3 Gene

Gene Ontology (GO) - Molecular Function for DPEP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DPEP3: view
genes like me logo Genes that share phenotypes with DPEP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DPEP3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPEP3 Gene

Localization for DPEP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP3 Gene

Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPEP3 Gene COMPARTMENTS Subcellular localization image for DPEP3 gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DPEP3 Gene

Pathways & Interactions for DPEP3 Gene

genes like me logo Genes that share pathways with DPEP3: view

Interacting Proteins for DPEP3 Gene

Gene Ontology (GO) - Biological Process for DPEP3 Gene

None

No data available for SIGNOR curated interactions for DPEP3 Gene

Drugs & Compounds for DPEP3 Gene

No Compound Related Data Available

Transcripts for DPEP3 Gene

mRNA/cDNA for DPEP3 Gene

Unigene Clusters for DPEP3 Gene

Dipeptidase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1:
SP2:

Relevant External Links for DPEP3 Gene

GeneLoc Exon Structure for
DPEP3
ECgene alternative splicing isoforms for
DPEP3

Expression for DPEP3 Gene

mRNA expression in normal human tissues for DPEP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP3 Gene

This gene is overexpressed in Testis (x39.8) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for DPEP3 Gene

This gene is overexpressed in Ovary (54.4) and Testis (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPEP3 Gene



SOURCE GeneReport for Unigene cluster for DPEP3 Gene Hs.302028

genes like me logo Genes that share expression patterns with DPEP3: view

Protein tissue co-expression partners for DPEP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DPEP3 Gene

Orthologs for DPEP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPEP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPEP3 35
  • 81.07 (n)
  • 73.5 (a)
DPEP3 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPEP3 35
  • 85.16 (n)
  • 81.43 (a)
DPEP3 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpep3 35
  • 79.58 (n)
  • 74.83 (a)
Dpep3 16
Dpep3 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPEP3 35
  • 97.86 (n)
  • 97.66 (a)
DPEP3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpep3 35
  • 80.18 (n)
  • 75.28 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100534995 35
  • 57.52 (n)
  • 56.02 (a)
DPEP3 36
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG34420 35
  • 52.84 (n)
  • 47.65 (a)
CG6154 36
  • 39 (a)
ManyToMany
CG5282 36
  • 23 (a)
ManyToMany
CG42750 36
  • 16 (a)
ManyToMany
CG34420 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
Species with no ortholog for DPEP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP3 Gene

ENSEMBL:
Gene Tree for DPEP3 (if available)
TreeFam:
Gene Tree for DPEP3 (if available)

Paralogs for DPEP3 Gene

Paralogs for DPEP3 Gene

(2) SIMAP similar genes for DPEP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DPEP3: view

Variants for DPEP3 Gene

Sequence variations from dbSNP and Humsavar for DPEP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs255048 -- 67,978,946(+) ACTAC(C/T)GAGCC intron-variant
rs255049 -- 67,979,568(+) CTGGC(C/T)GACCC intron-variant
rs255056 -- 67,982,282(+) gagag(C/G)cgtgg upstream-variant-2KB
rs61522389 -- 67,975,391(+) AAAAA(A/T)TTTAA downstream-variant-500B
rs16957670 -- 67,977,964(+) GCTGA(C/T)GTTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DPEP3 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906815 CNV Loss 21882294
nsv906816 CNV Loss 21882294

Variation tolerance for DPEP3 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.92; 74.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPEP3 Gene

HapMap Linkage Disequilibrium report
DPEP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPEP3 Gene

Disorders for DPEP3 Gene

Relevant External Links for DPEP3

Genetic Association Database (GAD)
DPEP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPEP3

No disorders were found for DPEP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPEP3 Gene

Publications for DPEP3 Gene

  1. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (PMID: 19060910) Sabatti C. … Peltonen L. (Nat. Genet. 2009) 3 48 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. HIV gp120 induced gene expression signatures in vaginal epithelial cells. (PMID: 23867815) Fanibunda S.E. … Bandivdekar A.H. (Microbes Infect. 2013) 3
  4. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. (PMID: 21555454) Rahman S. … Howley P.M. (Mol. Cell. Biol. 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DPEP3 Gene

Sources for DPEP3 Gene

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