External Ids for DPEP2 Gene
Previous GeneCards Identifiers for DPEP2 Gene
DPEP2 belongs to the membrane-bound dipeptidase (EC 220.127.116.11) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
GeneCards Summary for DPEP2 Gene
DPEP2 (Dipeptidase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include metallopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP1.
UniProtKB/Swiss-Prot for DPEP2 Gene
Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).