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Aliases for DPEP2 Gene

Aliases for DPEP2 Gene

  • Dipeptidase 2 2 3
  • EC 3.4.13.19 4 64
  • MBD2 3 6

External Ids for DPEP2 Gene

Summaries for DPEP2 Gene

Entrez Gene Summary for DPEP2 Gene

  • DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DPEP2 Gene

DPEP2 (Dipeptidase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include metalloexopeptidase activity and dipeptidyl-peptidase activity. An important paralog of this gene is DPEP1.

UniProtKB/Swiss-Prot for DPEP2 Gene

  • Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP2 Gene

Genomics for DPEP2 Gene

Genomic Location for DPEP2 Gene

Start:
67,987,390 bp from pter
End:
68,000,590 bp from pter
Size:
13,201 bases
Orientation:
Minus strand

Genomic View for DPEP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPEP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP2 Gene

Regulatory Elements for DPEP2 Gene

Proteins for DPEP2 Gene

  • Protein details for DPEP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4A9-DPEP2_HUMAN
    Recommended name:
    Dipeptidase 2
    Protein Accession:
    Q9H4A9
    Secondary Accessions:
    • B2RCF8
    • Q6UX92
    • Q8TC95

    Protein attributes for DPEP2 Gene

    Size:
    486 amino acids
    Molecular mass:
    53306 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAQ88819.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DPEP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPEP2 Gene

Proteomics data for DPEP2 Gene at MOPED

Selected DME Specific Peptides for DPEP2 Gene

Post-translational modifications for DPEP2 Gene

  • Glycosylation at Asn111, Asn176, and Asn235

Other Protein References for DPEP2 Gene

Domains for DPEP2 Gene

Gene Families for DPEP2 Gene

Protein Domains for DPEP2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

DPEP2_HUMAN
Family:
  • Belongs to the peptidase M19 family.:
    • Q9H4A9
genes like me logo Genes that share domains with DPEP2: view

Function for DPEP2 Gene

Molecular function for DPEP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function: Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).

Enzyme Numbers (IUBMB) for DPEP2 Gene

Gene Ontology (GO) - Molecular Function for DPEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008235 metalloexopeptidase activity IEA --
GO:0008237 metallopeptidase activity --
GO:0008238 exopeptidase activity --
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0016805 dipeptidase activity IEA --
genes like me logo Genes that share ontologies with DPEP2: view

miRNA for DPEP2 Gene

miRTarBase miRNAs that target DPEP2

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DPEP2 Gene

Localization for DPEP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP2 Gene

Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPEP2 Gene COMPARTMENTS Subcellular localization image for DPEP2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DPEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with DPEP2: view

Pathways for DPEP2 Gene

genes like me logo Genes that share pathways with DPEP2: view

Pathways by source for DPEP2 Gene

Interacting Proteins for DPEP2 Gene

Gene Ontology (GO) - Biological Process for DPEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006691 leukotriene metabolic process --
GO:0019369 arachidonic acid metabolic process --
GO:0044281 small molecule metabolic process --
genes like me logo Genes that share ontologies with DPEP2: view

Compounds for DPEP2 Gene

(2) HMDB Compounds for DPEP2 Gene

Compound Synonyms Cas Number PubMed IDs
10,11-Dihydro-12R-hydroxy-leukotriene E4
  • 5,12-dihydroxy-6-cysteinyl-7,9,14-eicosatrienoate
Not Available
Leukotriene E4
  • LTE4
75715-89-8
genes like me logo Genes that share compounds with DPEP2: view

Transcripts for DPEP2 Gene

Unigene Clusters for DPEP2 Gene

Dipeptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: -

Relevant External Links for DPEP2 Gene

GeneLoc Exon Structure for
DPEP2
ECgene alternative splicing isoforms for
DPEP2

Expression for DPEP2 Gene

mRNA expression in normal human tissues for DPEP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP2 Gene

This gene is overexpressed in Whole Blood (33.3) and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DPEP2 Gene

SOURCE GeneReport for Unigene cluster for DPEP2 Gene Hs.372633

genes like me logo Genes that share expressions with DPEP2: view

Orthologs for DPEP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPEP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPEP2 36
  • 99.73 (n)
  • 99.59 (a)
DPEP2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPEP2 36
  • 82.91 (n)
  • 80.32 (a)
DPEP2 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPEP2 36
  • 83.72 (n)
  • 81.48 (a)
mouse
(Mus musculus)
Mammalia Dpep2 36
  • 75.95 (n)
  • 72.16 (a)
Dpep2 16
Dpep2 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dpep2 36
  • 77.19 (n)
  • 72.41 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dpep2 36
  • 57.53 (n)
  • 58.31 (a)
zebrafish
(Danio rerio)
Actinopterygii DPEP3 37
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007854 36
  • 54.72 (n)
  • 47.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34420 37
  • 22 (a)
ManyToMany
CG42750 36
  • 56.37 (n)
  • 53.24 (a)
CG42750 37
  • 17 (a)
ManyToMany
CG5282 37
  • 24 (a)
ManyToMany
CG6154 37
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
Species with no ortholog for DPEP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP2 Gene

ENSEMBL:
Gene Tree for DPEP2 (if available)
TreeFam:
Gene Tree for DPEP2 (if available)

Paralogs for DPEP2 Gene

Paralogs for DPEP2 Gene

Selected SIMAP similar genes for DPEP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DPEP2: view

Variants for DPEP2 Gene

Sequence variations from dbSNP and Humsavar for DPEP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs255051 - 67,991,898(-) CTTAC(C/G)TACCT missense, reference, intron-variant, nc-transcript-variant
rs255052 -- 67,991,092(+) GGGGT(A/G)GAGTG intron-variant
rs1124323 -- 67,987,775(+) GCAGT(C/T)GGTGC intron-variant
rs1133089 -- 67,987,581(-) TCAGT(C/T)TCAGA reference, synonymous-codon, utr-variant-3-prime
rs1133090 - 67,987,565(-) CCCCC(C/G)ACATG reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DPEP2 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906816 CNV Loss 21882294
esv2671023 CNV Deletion 23128226

Relevant External Links for DPEP2 Gene

HapMap Linkage Disequilibrium report
DPEP2
Human Gene Mutation Database (HGMD)
DPEP2

Disorders for DPEP2 Gene

Relevant External Links for DPEP2

Genetic Association Database (GAD)
DPEP2
genes like me logo Genes that share disorders with DPEP2: view

No data available for UniProtKB/Swiss-Prot for DPEP2 Gene

Publications for DPEP2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  5. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PMID: 18193043) Willer C.J. … Abecasis G.R. (Nat. Genet. 2008) 3 49

Products for DPEP2 Gene

Sources for DPEP2 Gene

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