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DPEP2 Gene

protein-coding   GIFtS: 56
GCID: GC16M068021

Dipeptidase 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dipeptidase 21 2
EC 3.4.13.193 8
MBD22 5

External Ids:    HGNC: 230281   Entrez Gene: 641742   Ensembl: ENSG000001672617   OMIM: 6099255   UniProtKB: Q9H4A93   
ORGUL members:         

Export aliases for DPEP2 gene to outside databases

Previous GC identifers: GC16M067756 GC16M067797 GC16M066578 GC16M053894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPEP2 Gene:
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of
dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine
(cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 (PubMed 12738806)).(supplied by OMIM, Mar
2008)

GeneCards Summary for DPEP2 Gene:
DPEP2 (dipeptidase 2) is a protein-coding gene. Diseases associated with DPEP2 include coronary artery disease. GO annotations related to this gene include dipeptidyl-peptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP3.

UniProtKB/Swiss-Prot: DPEP2_HUMAN, Q9H4A9
Function: Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPEP2 gene promoter:
         HOXA9   HOXA9B   Nkx2-5   GATA-2   Meis-1b   CBF-A   NF-kappaB2   NF-kappaB1   Meis-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDPEP2 promoter sequence
   Search Chromatin IP Primers for DPEP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPEP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

DPEP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPEP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M068021:  view genomic region     (about GC identifiers)

Start:
68,021,293 bp from pter      End:
68,034,489 bp from pter
Size:
13,197 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPEP2_HUMAN, Q9H4A9 (See protein sequence)
Recommended Name: Dipeptidase 2 precursor  
Size: 486 amino acids; 53306 Da
Cofactor: Zinc (By similarity)
Subunit: Homodimer; disulfide-linked (By similarity)
Sequence caution: Sequence=AAQ88819.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RCF8 Q6UX92 Q8TC95
Alternative splicing: 2 isoforms:  Q9H4A9-1   Q9H4A9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DPEP2: NX_Q9H4A9

Explore proteomics data for DPEP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn111, Asn176, Asn235
  • Selected DME Specific Peptides for DPEP2 (Q9H4A9) (see all 6)
     DGHNDLP  APVIFSHS  PCQTQDRDA  CASYSELELVTS 


    See DPEP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071750.1  
    ENSEMBL proteins: 
     ENSP00000377430   ENSP00000459375   ENSP00000458977   ENSP00000462652   ENSP00000463604  
     ENSP00000460169   ENSP00000461250   ENSP00000412549  
    Reactome Protein details: Q9H4A9

    DPEP2 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for DPEP2
    Sino Biological Cell Lysate for DPEP2
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    DPEP2 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Dipeptidase 2
    Leukotriene and lipoxin metabolism

    3 InterPro protein domains:
     IPR000180 Renal_dipep_AS
     IPR028531 Dpep2
     IPR008257 Renal_dipep_fam

    Graphical View of Domain Structure for InterPro Entry Q9H4A9

    ProtoNet protein and cluster: Q9H4A9

    1 Blocks protein domain: IPB000180 Renal dipeptidase

    UniProtKB/Swiss-Prot: DPEP2_HUMAN, Q9H4A9
    Similarity: Belongs to the peptidase M19 family


    DPEP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPEP2_HUMAN, Q9H4A9
    Function: Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (By
    similarity)
    Catalytic activity: Hydrolysis of dipeptides
    Enzyme regulation: Inhibited by L-penicillamine (By similarity)

         Enzyme Number (IUBMB): EC 3.4.13.191 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008235metalloexopeptidase activity IEA--
    GO:0008238exopeptidase activity ----
    GO:0008239dipeptidyl-peptidase activity IEA--
    GO:0016805dipeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    DPEP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Dpep2 (no phenotypes)

    DPEP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dpep2tm1Lex for DPEP2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DPEP2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DPEP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DPEP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DPEP2:
    hsa-mir-375 (MIRT019870)

    Block miRNA regulation of human, mouse, rat DPEP2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DPEP2:
    hsa-miR-550a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DPEP2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DPEP2 (NM_022355)
    Sino Biological Human cDNA Clone for DPEP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DPEP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPEP2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPEP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPEP2_HUMAN, Q9H4A9: Membrane; Lipid-anchor, GPI-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0031225anchored component of membrane IEA--

    DPEP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DPEP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.40
    leukotriene biosynthesis0.00
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DPEP2
        DNA Methylation and Transcriptional Repression

    1 BioSystems Pathway for DPEP2
        leukotriene biosynthesis


    1 Reactome Pathway for DPEP2
        Synthesis of Leukotrienes (LT) and Eoxins (EX)

    1 PharmGKB Pathway for DPEP2
        Busulfan Pathway, Pharmacodynamics


    DPEP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPEP2
    Interactions:

        Search GeneGlobe Interaction Network for DPEP2

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006691leukotriene metabolic process TAS--
    GO:0019369arachidonic acid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    DPEP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DPEP2

    2 HMDB Compounds for DPEP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-Dihydro-12R-hydroxy-leukotriene E45,12-dihydroxy-6-cysteinyl-7,9,14-eicosatrienoate (see all 9)----
    Leukotriene E4LTE4 (see all 4)75715-89-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DPEP2 gene: 
    NM_022355.3  

    Unigene Cluster for DPEP2:

    Dipeptidase 2
    Hs.372633  [show with all ESTs]
    Unigene Representative Sequence: NM_022355
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393847 ENST00000575203(uc002evf.3) ENST00000572888(uc010cey.3)
    ENST00000575510 ENST00000573808 ENST00000268795(uc002evg.3) ENST00000572624
    ENST00000574865 ENST00000574316 ENST00000412757(uc002eve.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DPEP2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DPEP2:
    hsa-miR-550a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    OriGene qPCR primer pairs and template standards for DPEP2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DPEP2
      QuantiTect SYBR Green Assays in human, mouse, rat DPEP2
      QuantiFast Probe-based Assays in human, mouse, rat DPEP2

    Additional mRNA sequence: 

    AJ295149.1 AK315090.1 AY358454.1 BC024021.1 

    12 DOTS entries:

    DT.312370  DT.100709055  DT.95375439  DT.120665018  DT.95375445  DT.100777825  DT.100022880  DT.92420415 
    DT.95375442  DT.95375443  DT.95375446  DT.95375440 

    Selected AceView cDNA sequences (see all 98):

    CA308968 AI887572 CA418626 CB528462 BI909651 NM_022357 BE669521 BE670487 
    AY358454 BI836036 BC037243 AJ291679 AK057401 CA309354 CR625664 AW450595 
    AI969764 BG482712 AI419474 AI867862 AI524102 AX747789 BI831037 BF002311 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DPEP2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                                        -               
    SP2:                                -                                       


    ECgene alternative splicing isoforms for DPEP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPEP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCAGTCC
    DPEP2 Expression
    About this image


    DPEP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    DPEP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPEP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372633
        Custom PCR Arrays for DPEP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPEP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPEP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpep21 , 5 dipeptidase 21, 5 75.95(n)1
    72.16(a)1
      8 (53.07 cM)5
    3194461  NM_176913.31  NP_795887.21 
     1059849445 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    53(a)
    1 → many
    11(2943082-2953938)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    57(a)
    1 → many
    LGc(6193338-6207844)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dpep21 dipeptidase 2 57.53(n)
    58.31(a)
      100487272  XM_004913541.1  XP_004913598.1 
    zebrafish
    (Danio rerio)
    Actinopterygii DPEP36
    dipeptidase 3
    49(a)
    1 → many
    7(36723560-36736777) ENSDARG00000079216
    fruit fly
    (Drosophila melanogaster)
    Insecta CG427501 CG42750 56.37(n)
    53.24(a)
      35090  NM_165245.4  NP_724101.4 


    ENSEMBL Gene Tree for DPEP2 (if available)
    TreeFam Gene Tree for DPEP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPEP2 gene
    DPEP32  DPEP12  
    2 SIMAP similar genes for DPEP2 using alignment to 7 protein entries:     DPEP2_HUMAN (see all proteins):
    DPEP3    DPEP1

    DPEP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPEP2 (see all 347)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1437098851,2
    --69027362(+) AAGCAA/GAAGCT 1 -- int10--------
    rs1394224461,2
    C--69027460(+) AAAAG-/TAAAT 
     AAATAAA
    TAAAT
    1 -- int10--------
    rs1905558721,2
    --69027551(+) GCCACC/TGGATC 1 -- int10--------
    rs785390491,2
    C,F--69027554(+) ACCGGA/CTCCAC 1 -- int11Minor allele frequency- C:0.07NA 120
    rs21752401,2
    H--69027639(+) ACTGGT/CGGCTG 1 -- int14Minor allele frequency- C:0.00NS EA 416
    rs1134586431,2
    C,F--69027676(+) AGCACC/TGGGAG 1 -- int12Minor allele frequency- T:0.50CSA 6
    rs20423871,2
    C,H--69027706(+) TTGCAG/AAGAAG 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs1860515971,2
    C--69027797(+) TGTCTA/GTGGCT 1 -- ut310--------
    rs1995221911,2
    C--69027798(+) GTCTGT/GGGCTT 1 -- ut311Minor allele frequency- G:0.00EU 1087
    rs1906272991,2
    C--69027808(+) TGCTAC/TAGTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DPEP2 (68021293 - 68034489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DPEP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671023CNV Deletion23128226
    nsv906816CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DPEP2
    DNA2.0 Custom Variant and Variant Library Synthesis for DPEP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609925    OMIM disorders: --

    1 disease for DPEP2:    
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    coronary artery disease


    DPEP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DPEP2

    Export disorders for DPEP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPEP2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with DPEP2)
        Utopia: connect your pdf to the dynamic
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    1. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PubMed id 18193043)1, 4 Willer C.J....Abecasis G.R. (Nat. Genet. 2008)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    9. Identification of two additional members of the membrane-bound dipeptidase family. (PubMed id 12738806)1 Habib G.M....Lieberman M.W. (FASEB J. 2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64174 HGNC: 23028 AceView: DPEP2andDPEP3 Ensembl:ENSG00000167261 euGenes: HUgn64174
    ECgene: DPEP2 H-InvDB: DPEP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPEP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPEP2 gene:
    Search GeneIP for patents involving DPEP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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