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Aliases for DPEP2 Gene

Aliases for DPEP2 Gene

  • Dipeptidase 2 2 3 5
  • EC 3.4.13.19 4 63
  • MBD2 3

External Ids for DPEP2 Gene

Previous GeneCards Identifiers for DPEP2 Gene

  • GC16M067756
  • GC16M067797
  • GC16M066578
  • GC16M068021
  • GC16M053894

Summaries for DPEP2 Gene

Entrez Gene Summary for DPEP2 Gene

  • DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DPEP2 Gene

DPEP2 (Dipeptidase 2) is a Protein Coding gene. Among its related pathways are Aflatoxin activation and detoxification and Arachidonic acid metabolism. GO annotations related to this gene include metallopeptidase activity and metalloexopeptidase activity. An important paralog of this gene is DPEP1.

UniProtKB/Swiss-Prot for DPEP2 Gene

  • Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP2 Gene

Genomics for DPEP2 Gene

Regulatory Elements for DPEP2 Gene

Enhancers for DPEP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPEP2 on UCSC Golden Path with GeneCards custom track

Promoters for DPEP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DPEP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPEP2 Gene

Chromosome:
16
Start:
67,987,390 bp from pter
End:
68,000,611 bp from pter
Size:
13,222 bases
Orientation:
Minus strand

Genomic View for DPEP2 Gene

Genes around DPEP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPEP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPEP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP2 Gene

Proteins for DPEP2 Gene

  • Protein details for DPEP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4A9-DPEP2_HUMAN
    Recommended name:
    Dipeptidase 2
    Protein Accession:
    Q9H4A9
    Secondary Accessions:
    • B2RCF8
    • Q6UX92
    • Q8TC95

    Protein attributes for DPEP2 Gene

    Size:
    486 amino acids
    Molecular mass:
    53306 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AAQ88819.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DPEP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DPEP2 Gene

Proteomics data for DPEP2 Gene at MOPED

Selected DME Specific Peptides for DPEP2 Gene

Post-translational modifications for DPEP2 Gene

  • Glycosylation at Asn 111, Asn 176, and Asn 235
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DPEP2

Domains & Families for DPEP2 Gene

Gene Families for DPEP2 Gene

IUPHAR :

Protein Domains for DPEP2 Gene

Suggested Antigen Peptide Sequences for DPEP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4A9

UniProtKB/Swiss-Prot:

DPEP2_HUMAN :
  • Belongs to the peptidase M19 family.
Family:
  • Belongs to the peptidase M19 family.
genes like me logo Genes that share domains with DPEP2: view

Function for DPEP2 Gene

Molecular function for DPEP2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function:
Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).

Enzyme Numbers (IUBMB) for DPEP2 Gene

Gene Ontology (GO) - Molecular Function for DPEP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008235 metalloexopeptidase activity IEA --
GO:0008238 exopeptidase activity IEA --
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0016805 dipeptidase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DPEP2: view
genes like me logo Genes that share phenotypes with DPEP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DPEP2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DPEP2 Gene

Localization for DPEP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP2 Gene

Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPEP2 Gene COMPARTMENTS Subcellular localization image for DPEP2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DPEP2 Gene

Pathways & Interactions for DPEP2 Gene

genes like me logo Genes that share pathways with DPEP2: view

Pathways by source for DPEP2 Gene

Interacting Proteins for DPEP2 Gene

Gene Ontology (GO) - Biological Process for DPEP2 Gene

None

No data available for SIGNOR curated interactions for DPEP2 Gene

Drugs & Compounds for DPEP2 Gene

(1) Additional Compounds for DPEP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Leukotriene E4
  • 20-Hydroxy-leukotriene E4
  • 20-OH-Leukotriene E4
  • LTE4
  • [5S-[5R*,6S*(S*),7E,9E,11Z,14Z]]- 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-Eicosatetraenoate
  • [5S-[5R*,6S*(S*),7E,9E,11Z,14Z]]- 6-[(2-amino-2-carboxyethyl)thio]-5-hydroxy-7,9,11,14-Eicosatetraenoic acid
75715-89-8
genes like me logo Genes that share compounds with DPEP2: view

Transcripts for DPEP2 Gene

Unigene Clusters for DPEP2 Gene

Dipeptidase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: -

Relevant External Links for DPEP2 Gene

GeneLoc Exon Structure for
DPEP2
ECgene alternative splicing isoforms for
DPEP2

Expression for DPEP2 Gene

mRNA expression in normal human tissues for DPEP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP2 Gene

This gene is overexpressed in Whole Blood (x33.3) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for DPEP2 Gene

This gene is overexpressed in Serum (51.4) and Plasma (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DPEP2 Gene



SOURCE GeneReport for Unigene cluster for DPEP2 Gene Hs.372633

genes like me logo Genes that share expression patterns with DPEP2: view

Protein tissue co-expression partners for DPEP2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DPEP2 Gene

Orthologs for DPEP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DPEP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPEP2 35
  • 82.91 (n)
  • 80.32 (a)
DPEP2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPEP2 35
  • 83.72 (n)
  • 81.48 (a)
mouse
(Mus musculus)
Mammalia Dpep2 35
  • 75.95 (n)
  • 72.16 (a)
Dpep2 16
Dpep2 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPEP2 35
  • 99.73 (n)
  • 99.59 (a)
DPEP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpep2 35
  • 77.19 (n)
  • 72.41 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dpep2 35
  • 57.53 (n)
  • 58.31 (a)
zebrafish
(Danio rerio)
Actinopterygii DPEP3 36
  • 49 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007854 35
  • 54.72 (n)
  • 47.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42750 35
  • 56.37 (n)
  • 53.24 (a)
CG34420 36
  • 22 (a)
ManyToMany
CG42750 36
  • 17 (a)
ManyToMany
CG5282 36
  • 24 (a)
ManyToMany
CG6154 36
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
Species with no ortholog for DPEP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP2 Gene

ENSEMBL:
Gene Tree for DPEP2 (if available)
TreeFam:
Gene Tree for DPEP2 (if available)

Paralogs for DPEP2 Gene

Paralogs for DPEP2 Gene

(2) SIMAP similar genes for DPEP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DPEP2: view

Variants for DPEP2 Gene

Sequence variations from dbSNP and Humsavar for DPEP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1133090 - 67,987,565(-) CCCCC(A/C/G/T)ACATG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs255051 - 67,991,898(-) CTTAC(C/G)TACCT intron-variant, nc-transcript-variant, reference, missense
rs255052 -- 67,991,092(+) GGGGT(A/G)GAGTG intron-variant
rs12935473 -- 67,997,018(+) attat(A/T)attat intron-variant
rs13330015 -- 68,001,160(+) tcttg(C/T)tctgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DPEP2 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906816 CNV Loss 21882294
esv2671023 CNV Deletion 23128226

Variation tolerance for DPEP2 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.86; 48.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPEP2 Gene

Human Gene Mutation Database (HGMD)
DPEP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPEP2 Gene

Disorders for DPEP2 Gene

Relevant External Links for DPEP2

Genetic Association Database (GAD)
DPEP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPEP2

No disorders were found for DPEP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPEP2 Gene

Publications for DPEP2 Gene

  1. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PMID: 18193043) Willer C.J. … Abecasis G.R. (Nat. Genet. 2008) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. (PMID: 21555454) Rahman S. … Howley P.M. (Mol. Cell. Biol. 2011) 3
  5. Colocalization of a carnosine-splitting enzyme, tissue carnosinase (CN2)/cytosolic non-specific dipeptidase 2 (CNDP2), with histidine decarboxylase in the tuberomammillary nucleus of the hypothalamus. (PMID: 18790006) Otani H. … Okumura N. (Neurosci. Lett. 2008) 23

Products for DPEP2 Gene

Sources for DPEP2 Gene

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