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Aliases for DPEP1 Gene

Aliases for DPEP1 Gene

  • Dipeptidase 1 (Renal) 2 3 5
  • Microsomal Dipeptidase 3 4
  • Dehydropeptidase-I 3 4
  • Renal Dipeptidase 3 4
  • EC 4 63
  • HRDP 3 4
  • RDP 3 4
  • MDP 3 4
  • Testicular Tissue Protein Li 57 3
  • MBD1 3

External Ids for DPEP1 Gene

Previous GeneCards Identifiers for DPEP1 Gene

  • GC16P081008
  • GC16P090676
  • GC16P089390
  • GC16P089430
  • GC16P088214
  • GC16P089679
  • GC16P075374

Summaries for DPEP1 Gene

Entrez Gene Summary for DPEP1 Gene

  • The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for DPEP1 Gene

DPEP1 (Dipeptidase 1 (Renal)) is a Protein Coding gene. Among its related pathways are Aflatoxin activation and detoxification and Arachidonic acid metabolism. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is DPEP2.

UniProtKB/Swiss-Prot for DPEP1 Gene

  • Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.

Gene Wiki entry for DPEP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP1 Gene

Genomics for DPEP1 Gene

Regulatory Elements for DPEP1 Gene

Enhancers for DPEP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DPEP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DPEP1 Gene

89,613,308 bp from pter
89,640,862 bp from pter
27,555 bases
Plus strand

Genomic View for DPEP1 Gene

Genes around DPEP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPEP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP1 Gene

Proteins for DPEP1 Gene

  • Protein details for DPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dipeptidase 1
    Protein Accession:
    Secondary Accessions:
    • D3DX80
    • Q96AK2

    Protein attributes for DPEP1 Gene

    411 amino acids
    Molecular mass:
    45674 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for DPEP1 Gene

neXtProt entry for DPEP1 Gene

Proteomics data for DPEP1 Gene at MOPED

Post-translational modifications for DPEP1 Gene

  • Glycosylation at Asn 57, Asn 279, Asn 332, and Asn 358
  • Modification sites at PhosphoSitePlus

Other Protein References for DPEP1 Gene

Antibody Products

  • Abcam antibodies for DPEP1

Domains & Families for DPEP1 Gene

Gene Families for DPEP1 Gene


Protein Domains for DPEP1 Gene

Suggested Antigen Peptide Sequences for DPEP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M19 family.
  • Belongs to the peptidase M19 family.
genes like me logo Genes that share domains with DPEP1: view

Function for DPEP1 Gene

Molecular function for DPEP1 Gene

GENATLAS Biochemistry:
dipeptidase 1 (renal)
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function:
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.

Enzyme Numbers (IUBMB) for DPEP1 Gene

Gene Ontology (GO) - Molecular Function for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IDA 19879002
GO:0072341 modified amino acid binding IDA 20031578
genes like me logo Genes that share ontologies with DPEP1: view
genes like me logo Genes that share phenotypes with DPEP1: view

Human Phenotype Ontology for DPEP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DPEP1 Gene

MGI Knock Outs for DPEP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DPEP1

No data available for Transcription Factor Targets and HOMER Transcription for DPEP1 Gene

Localization for DPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP1 Gene

Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor. Note=Brush border membrane.

Subcellular locations from

Jensen Localization Image for DPEP1 Gene COMPARTMENTS Subcellular localization image for DPEP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DPEP1 Gene

Pathways & Interactions for DPEP1 Gene

genes like me logo Genes that share pathways with DPEP1: view

Pathways by source for DPEP1 Gene

Interacting Proteins for DPEP1 Gene

Gene Ontology (GO) - Biological Process for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006691 leukotriene metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0072340 cellular lactam catabolic process TAS 12144777
genes like me logo Genes that share ontologies with DPEP1: view

No data available for SIGNOR curated interactions for DPEP1 Gene

Drugs & Compounds for DPEP1 Gene

(13) Drugs for DPEP1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cilastatin Approved Pharma Inhibition, Inhibitor, inhibitor, Target 29
Zinc Approved Pharma 2102

(16) Additional Compounds for DPEP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DPEP1: view

Transcripts for DPEP1 Gene

Unigene Clusters for DPEP1 Gene

Dipeptidase 1 (renal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP1 Gene

No ASD Table

Relevant External Links for DPEP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPEP1 Gene

mRNA expression in normal human tissues for DPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.2), Pancreas (x15.8), and Kidney - Cortex (x12.0).

Protein differential expression in normal tissues from HIPED for DPEP1 Gene

This gene is overexpressed in Urine (22.3), Ovary (18.4), Testis (13.1), and Kidney (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPEP1 Gene

SOURCE GeneReport for Unigene cluster for DPEP1 Gene Hs.109

genes like me logo Genes that share expression patterns with DPEP1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DPEP1 Gene

Orthologs for DPEP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DPEP1 35
  • 84.1 (n)
  • 81.54 (a)
DPEP1 36
  • 80 (a)
(Canis familiaris)
Mammalia DPEP1 35
  • 82.03 (n)
  • 77.8 (a)
DPEP1 36
  • 78 (a)
(Mus musculus)
Mammalia Dpep1 35
  • 76.6 (n)
  • 72.91 (a)
Dpep1 16
Dpep1 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Dpep1 35
  • 77.42 (n)
  • 74.38 (a)
(Monodelphis domestica)
Mammalia DPEP1 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia DPEP1 36
  • 64 (a)
(Pan troglodytes)
Mammalia DPEP1 36
  • 95 (a)
(Gallus gallus)
Aves DPEP1 35
  • 71.32 (n)
  • 67.11 (a)
DPEP1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia DPEP1 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dpep1 35
  • 61.43 (n)
  • 62.34 (a)
(Danio rerio)
Actinopterygii dpep1 35
  • 61 (n)
  • 60.31 (a)
dpep1 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5282 37
  • 28 (a)
CG5917 37
  • 44 (a)
CG6154 37
  • 51 (a)
CG6154 35
  • 57.63 (n)
  • 50.68 (a)
CG34420 36
  • 19 (a)
CG42750 36
  • 14 (a)
CG5282 36
  • 22 (a)
CG6154 36
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002634 35
  • 57.18 (n)
  • 51.49 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09538 35
  • 54.38 (n)
  • 46.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3A11.10c 35
  • 47.73 (n)
  • 45.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
-- 36
  • 50 (a)
Species with no ortholog for DPEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP1 Gene

Gene Tree for DPEP1 (if available)
Gene Tree for DPEP1 (if available)

Paralogs for DPEP1 Gene

Paralogs for DPEP1 Gene

(2) SIMAP similar genes for DPEP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DPEP1: view

Variants for DPEP1 Gene

Sequence variations from dbSNP and Humsavar for DPEP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036496 A colorectal cancer sample
rs1126464 -, - 89,637,957(+) TCTTC(A/C/G)AGGCT reference, missense
rs154665 -- 89,624,280(-) GCCAC(A/G)CTTCC intron-variant
rs164741 -- 89,625,890(-) ACCAC(C/T)GTTCA intron-variant
rs164750 -- 89,641,245(-) ggaag(A/G)tctga downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DPEP1 Gene

Variant ID Type Subtype PubMed ID
nsv907357 CNV Loss 21882294
nsv428331 CNV Gain+Loss 18775914
dgv3008n71 CNV Loss 21882294
dgv3009n71 CNV Loss 21882294
nsv509639 CNV Insertion 20534489
dgv3010n71 CNV Loss 21882294
nsv1929 CNV Insertion 18451855
esv2715182 CNV Deletion 23290073
nsv103438 CNV Loss 16902084
nsv907419 CNV Gain 21882294
esv1242032 CNV Insertion 17803354
esv24216 CNV Loss 19812545
esv1355826 CNV Insertion 17803354
nsv907420 CNV Loss 21882294
nsv907421 CNV Loss 21882294
esv7562 CNV Gain 19470904
nsv1930 CNV Insertion 18451855
esv2715183 CNV Deletion 23290073
esv2676847 CNV Deletion 23128226
esv2715184 CNV Deletion 23290073
esv2715186 CNV Deletion 23290073
esv2715187 CNV Deletion 23290073
esv2715188 CNV Deletion 23290073

Variation tolerance for DPEP1 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DPEP1 Gene

Disorders for DPEP1 Gene

Relevant External Links for DPEP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DPEP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DPEP1 Gene

Publications for DPEP1 Gene

  1. Primary structure of human microsomal dipeptidase deduced from molecular cloning. (PMID: 2303490) Adachi H. … Nakazato H. (J. Biol. Chem. 1990) 3 4 23 67
  2. The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA. (PMID: 7492120) Keynan S. … Turner A.J. (Antimicrob. Agents Chemother. 1995) 23 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. Dipeptidase 1: a candidate tumor-specific molecular marker in colorectal carcinoma. (PMID: 15145522) McIver C.M. … Hardingham J.E. (Cancer Lett. 2004) 3 23

Products for DPEP1 Gene

Sources for DPEP1 Gene