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DPEP1 Gene

protein-coding   GIFtS: 67
GCID: GC16P089679

Dipeptidase 1 (Renal)

  See DPEP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dipeptidase 1 (Renal)1 2     EC 3.4.13.193 8
MDP2 3 5     MBD12 5
RDP2 3 5     dehydropeptidase-I2
Microsomal Dipeptidase2 3     Dipeptidase 12
Renal Dipeptidase2 3     Dehydropeptidase-I3
hRDP2 3     

External Ids:    HGNC: 30021   Entrez Gene: 18002   Ensembl: ENSG000000154137   OMIM: 1797805   UniProtKB: P164443   

Export aliases for DPEP1 gene to outside databases

Previous GC identifers: GC16P081008 GC16P090676 GC16P089390 GC16P089430 GC16P088214 GC16P075374


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DPEP1 Gene:
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other
similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by
catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a
disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Jan 2012)

GeneCards Summary for DPEP1 Gene:
DPEP1 (dipeptidase 1 (renal)) is a protein-coding gene. Diseases associated with DPEP1 include acute hemorrhagic conjunctivitis, and blau syndrome. GO annotations related to this gene include dipeptidyl-peptidase activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. An important paralog of this gene is DPEP2.

UniProtKB/Swiss-Prot: DPEP1_HUMAN, P16444
Function: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its
conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of
leukotriene activity

Gene Wiki entry for DPEP1 (Dipeptidase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DPEP1 gene promoter:
         NF-1   AP-1   AP-4   LUN-1   E47   Max   c-Myc   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DPEP1 promoter sequence
   Search Chromatin IP Primers for DPEP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DPEP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24

DPEP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DPEP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089679:  view genomic region     (about GC identifiers)

Start:
89,679,716 bp from pter      End:
89,704,839 bp from pter
Size:
25,124 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DPEP1_HUMAN, P16444 (See protein sequence)
Recommended Name: Dipeptidase 1 precursor  
Size: 411 amino acids; 45674 Da
Cofactor: Zinc
Subunit: Homodimer; disulfide-linked
2 PDB 3D structures from and Proteopedia for DPEP1:
1ITQ (3D)        1ITU (3D)    
Secondary accessions: D3DX80 Q96AK2

Explore the universe of human proteins at neXtProt for DPEP1: NX_P16444

Explore proteomics data for DPEP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn279, Asn332, Asn358
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DPEP1 (P16444) (see all 10)
     SLVMVNF  VGGQFWS  DGHNDLP  RNVPDDVL 


    See DPEP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121613.1  NP_004404.1  

    ENSEMBL proteins: 
     ENSP00000455916   ENSP00000455142   ENSP00000376807   ENSP00000261615   ENSP00000397313  
    Reactome Protein details: P16444

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Dipeptidase 1
    Leukotriene and lipoxin metabolism

    3 InterPro protein domains:
     IPR000180 Renal_dipep_AS
     IPR028536 Dpep1-like
     IPR008257 Renal_dipep_fam

    Graphical View of Domain Structure for InterPro Entry P16444

    ProtoNet protein and cluster: P16444

    1 Blocks protein domain: IPB000180 Renal dipeptidase

    UniProtKB/Swiss-Prot: DPEP1_HUMAN, P16444
    Similarity: Belongs to the peptidase M19 family


    Find genes that share domains with DPEP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPEP1_HUMAN, P16444
    Function: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its
    conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of
    leukotriene activity
    Catalytic activity: Hydrolysis of dipeptides
    Enzyme regulation: Inhibited by L-penicillamine (By similarity)

         Genatlas biochemistry entry for DPEP1:
    dipeptidase 1 (renal)

         Enzyme Number (IUBMB): EC 3.4.13.191 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008235metalloexopeptidase activity TAS2303490
    GO:0008239dipeptidyl-peptidase activity IEA--
    GO:0008270zinc ion binding IDA19879002
    GO:0016805dipeptidase activity ----
         
    Find genes that share ontologies with DPEP1           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dpep1):
     normal 

    Find genes that share phenotypes with DPEP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dpep1tm1Mwl for DPEP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPEP1_HUMAN, P16444: Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane;
    Lipid-anchor, GPI-anchor. Note=Brush border membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular4
    cytosol1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space ISS--
    GO:0005886plasma membrane TAS--
    GO:0016324apical plasma membrane IEA--
    GO:0031225anchored component of membrane IEA--
    GO:0031528microvillus membrane IEA--

    Find genes that share ontologies with DPEP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DPEP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.40
    leukotriene biosynthesis0.00
    Synthesis of Leukotrienes (LT) and Eoxins (EX)0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Eicosanoid Synthesis
    Eicosanoid Synthesis
    4Busulfan Pathway, Pharmacodynamics
    Busulfan Pathway, Pharmacodynamics


    Find genes that share SuperPaths with DPEP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DPEP1
        Eicosanoid Synthesis
    leukotriene biosynthesis


    1 Reactome Pathway for DPEP1
        Synthesis of Leukotrienes (LT) and Eoxins (EX)

    1 PharmGKB Pathway for DPEP1
        Busulfan Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DPEP1
    Interactions:

        GeneGlobe Interaction Network for DPEP1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for DPEP1 (P164441, 2, 3 ENSP000002616154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA1279Q96EK51, 2, 3, ENSP000003548484EBI-749514,EBI-744150 MINT-67539 I2D: score=6 STRING: ENSP00000354848
    MBD1ENSP000002694684STRING: ENSP00000269468
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006691leukotriene metabolic process TAS--
    GO:0006749glutathione metabolic process TAS--
    GO:0016999antibiotic metabolic process IDA8737157
    GO:0019369arachidonic acid metabolic process TAS--

    Find genes that share ontologies with DPEP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for DPEP1

    2 HMDB Compounds for DPEP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    10,11-Dihydro-12R-hydroxy-leukotriene E45,12-dihydroxy-6-cysteinyl-7,9,14-eicosatrienoate (see all 9)----
    ZincZinc (see all 2)7440-66-6--

    1 DrugBank Compound for DPEP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cilastatin-- 82009-34-5targetinhibitor3780719 3474745 7492120 2571484 17139284 3480361 11752352 17016423 9573653 3038022

    1 IUPHAR Ligand for DPEP1 (Dipeptidase 1)    About this table
    LigandTypeActionAffinityPubmed IDs
    cilastatin
    InhibitorInhibition3863619

    Selected Novoseek inferred chemical compound relationships for DPEP1 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoglutamine 86.6 3 1783471 (1), 10328973 (1)
    muramyl tripeptide phosphatidylethanolamine 82.4 6 1722107 (1), 8590897 (1), 7804354 (1), 1569602 (1)
    romurtide 81 11 7928300 (7), 7666614 (1)
    cilastatin 78.4 9 18611786 (1), 7492120 (1), 9291128 (1), 9410067 (1) (see all 9)
    murabutide 73.6 5 11449348 (2), 8620558 (2)
    peptidoglycan 69.6 26 20052476 (3), 12527755 (3), 18385071 (2), 16186640 (1) (see all 14)
    muramyl dipeptide 61.1 16 9242715 (9), 8502118 (3)
    squalane 59 1 10525443 (1)
    meropenem 58.7 6 18611786 (1), 14584966 (1), 9126702 (1), 8514637 (1) (see all 5)
    imipenem 56.2 6 18611786 (1), 14584966 (1), 7797442 (1), 2338416 (1) (see all 6)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DPEP1 gene (2 alternative transcripts): 
    NM_001128141.2  NM_004413.3  

    Unigene Cluster for DPEP1:

    Dipeptidase 1 (renal)
    Hs.109  [show with all ESTs]
    Unigene Representative Sequence: NM_004413
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570029 ENST00000565249 ENST00000564281 ENST00000568281 ENST00000393092(uc002fnr.4)
    ENST00000561484 ENST00000261615(uc002fns.4) ENST00000564645 ENST00000421184(uc010cin.3)

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    Additional mRNA sequence: 

    AK309577.1 BC017023.1 BT006664.1 CR457404.1 D13138.1 J05257.1 

    4 DOTS entries:

    DT.443995  DT.92419371  DT.86852043  DT.95192804 

    Selected AceView cDNA sequences (see all 60):

    CR620135 AW007143 AI269220 AA588149 BM068756 CK904606 BC017023 BE617365 
    AL535660 AA863424 BI760864 BE044322 BI829468 BI760089 BI828100 D13138 
    BI763889 BI825408 AI419892 BI761005 J05257 NM_004413 AA740647 AA612902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DPEP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGGACCAG
    DPEP1 Expression
    About this image


    DPEP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Proximal Tubule Cells Proximal Tubule
             Metanephros
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
    DPEP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DPEP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.109
        Custom PCR Arrays for DPEP1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DPEP1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dpep11 , 5 dipeptidase 1 (renal)1, 5 76.6(n)1
    72.91(a)1
      8 (72.08 cM)5
    134791  NM_007876.21  NP_031902.21 
     1231862355 
    chicken
    (Gallus gallus)
    Aves DPEP11 dipeptidase 1 (renal) 71.32(n)
    67.11(a)
      415842  XM_004944320.1  XP_004944377.1 
    lizard
    (Anolis carolinensis)
    Reptilia DPEP16
    dipeptidase 1 (renal)
    55(a)
    1 ↔ 1
    GL343487.1(574486-590703)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dpep11 dipeptidase 1 (renal) 61.43(n)
    62.34(a)
      100486414  XM_002933661.2  XP_002933707.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dpep11 dipeptidase 1 (renal) 61(n)
    60.31(a)
      768195  NM_001077337.1  NP_001070805.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61541 , 3 membrane dipeptidase3
    CG61541
    51(a)
    (best of 3)3
    57.63(n)1
    50.68(a)1
      97A73
    431841  NM_143214.21  NP_651471.21 


    ENSEMBL Gene Tree for DPEP1 (if available)
    TreeFam Gene Tree for DPEP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DPEP1 gene
    DPEP22  DPEP32  
    2 SIMAP similar genes for DPEP1 using alignment to 4 protein entries:     DPEP1_HUMAN (see all proteins):
    DPEP2    DPEP3

    Find genes that share paralogs with DPEP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DPEP1 (see all 1104)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364964
    A colorectal cancer sample4--see VAR_0364962 R H mis40--------
    rs1382833571,2
    C--75400909(+) CTGCAC/GACACC 1 -- ds50010--------
    rs1491810861,2
    --75400919(+) TCATCC/GTTGCA 1 -- ds50010--------
    rs1839395171,2
    --75400947(+) TGCACA/GCACAC 1 -- ds50010--------
    rs1998299331,2
    --75400971(+) CCCTG-/CACACAC 1 -- ds50010--------
    rs1896293561,2
    --75400985(+) CCCACC/TCCTGC 1 -- ds50010--------
    rs1923199011,2
    --75401077(+) CCCCTC/GCACAC 1 -- ds50010--------
    rs1431008231,2
    --75401098(+) ACAACC/TCATCC 1 -- ds50010--------
    rs1458966651,2
    --89677875(+) CCACAC/TTTTGA 1 -- us2k10--------
    rs740372411,2
    C,F--89677944(+) CTCTCG/AGCCCT 1 -- us2k12Minor allele frequency- A:0.08WA 120

    HapMap Linkage Disequilibrium report for DPEP1 (89679716 - 89704839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DPEP1 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676847CNV Deletion23128226
    esv2715184CNV Deletion23290073
    esv2715183CNV Deletion23290073
    esv2715186CNV Deletion23290073
    esv2715188CNV Deletion23290073
    esv2715182CNV Deletion23290073
    esv2715187CNV Deletion23290073
    esv1242032CNV Insertion17803354
    nsv1929CNV Insertion18451855
    esv1355826CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DPEP1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179780    OMIM disorders: --

    2 diseases for DPEP1:    
    About MalaCards
    acute hemorrhagic conjunctivitis    blau syndrome

    1 disease from the University of Copenhagen DISEASES database for DPEP1:
    Pyelonephritis

    Find genes that share disorders with DPEP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DPEP1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    blau syndrome 85.4 1 16414084 (1)
    gram-positive bacterial infections 56.5 1 16148175 (1)
    necrosis 40.7 14 7928300 (2), 8032541 (1), 19438594 (1), 19572373 (1) (see all 12)
    bacterial infections 32.1 3 9852241 (2), 16148175 (1)
    inflammation 30.8 13 8231652 (2), 16328452 (1), 16164210 (1), 16465024 (1) (see all 9)
    leishmaniasis visceral 25 1 9164956 (1)
    colorectal tumors 18.5 2 15177467 (1)
    lung metastases 12.5 4 16373855 (1)
    tumors 10.5 22 8032541 (5), 2074443 (2), 8054581 (2), 7928300 (2) (see all 12)
    colitis ulcerative 1.8 2 16328452 (1), 15198989 (1)

    Genetic Association Database (GAD): DPEP1
    Human Genome Epidemiology (HuGE) Navigator: DPEP1 (1 document)

    Export disorders for DPEP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DPEP1 gene, integrated from 10 sources (see all 183):
    (articles sorted by number of sources associating them with DPEP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human microsomal dipeptidase deduced from molecular cloning. (PubMed id 2303490)1, 2, 9 Adachi H.... Nakazato H. (J. Biol. Chem. 1990)
    2. Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme. (PubMed id 2137335)1, 2, 9 Hooper N.M.... Turner A.J. (Biochem. J. 1990)
    3. Gene structural analysis and expression of human renal dipeptidase. (PubMed id 7764673)1, 2, 9 Satoh S....Kohsaka M. (Biotechnol. Prog. 1994)
    4. Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. (PubMed id 12144777)1, 2, 9 Nitanai Y.... Tsujimoto M. (J. Mol. Biol. 2002)
    5. Importance of Glu-125 in the catalytic activity of human renal dipeptidase. (PubMed id 8097406)1, 2, 9 Adachi H.... Tsujimoto M. (Biochim. Biophys. Acta 1993)
    6. Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study. (PubMed id 20031578)1, 4 ParAc G....Ridker P.M. (Circ Cardiovasc Genet 2009)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Cloning and structural analysis of genomic DNA for human renal dipeptidase. (PubMed id 8439558)1, 2 Satoh S.... Kohsaka M. (Biochim. Biophys. Acta 1993)
    10. Identification of membrane anchoring site of human renal dipeptidase and construction and expression of a cDNA for its secretory form. (PubMed id 2168407)1, 2 Adachi H....Nakazato H. (J. Biol. Chem. 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1800 HGNC: 3002 AceView: DPEP1 Ensembl:ENSG00000015413 euGenes: HUgn1800
    ECgene: DPEP1 H-InvDB: DPEP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DPEP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DPEP1 gene:
    Search GeneIP for patents involving DPEP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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