Aliases for DPEP1 Gene
External Ids for DPEP1 Gene
Previous GeneCards Identifiers for DPEP1 Gene
The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for DPEP1 Gene
DPEP1 (Dipeptidase 1 (Renal)) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity. An important paralog of this gene is DPEP2.
UniProtKB/Swiss-Prot for DPEP1 Gene
Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.