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Aliases for DPEP1 Gene

Aliases for DPEP1 Gene

  • Dipeptidase 1 (Renal) 2 3
  • MDP 3 4 6
  • RDP 3 4 6
  • Microsomal Dipeptidase 3 4
  • Dehydropeptidase-I 3 4
  • Renal Dipeptidase 3 4
  • EC 3.4.13.19 4 63
  • MBD1 3 6
  • HRDP 3 4
  • Dipeptidase 1 3

External Ids for DPEP1 Gene

Summaries for DPEP1 Gene

Entrez Gene Summary for DPEP1 Gene

  • The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for DPEP1 Gene

DPEP1 (Dipeptidase 1 (Renal)) is a Protein Coding gene. Diseases associated with DPEP1 include acute hemorrhagic conjunctivitis and blau syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity involved in apoptotic process and dipeptidyl-peptidase activity. An important paralog of this gene is DPEP3.

UniProtKB/Swiss-Prot for DPEP1 Gene

  • Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity

Gene Wiki entry for DPEP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPEP1 Gene

Genomics for DPEP1 Gene

Genomic Location for DPEP1 Gene

Start:
89,613,308 bp from pter
End:
89,640,808 bp from pter
Size:
27,501 bases
Orientation:
Plus strand

Genomic View for DPEP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPEP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPEP1 Gene

Regulatory Elements for DPEP1 Gene

Proteins for DPEP1 Gene

  • Protein details for DPEP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16444-DPEP1_HUMAN
    Recommended name:
    Dipeptidase 1
    Protein Accession:
    P16444
    Secondary Accessions:
    • D3DX80
    • Q96AK2

    Protein attributes for DPEP1 Gene

    Size:
    411 amino acids
    Molecular mass:
    45674 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for DPEP1 Gene

neXtProt entry for DPEP1 Gene

Proteomics data for DPEP1 Gene at MOPED

Post-translational modifications for DPEP1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn57, Asn279, Asn332, and Asn358

Other Protein References for DPEP1 Gene

Domains for DPEP1 Gene

Gene Families for DPEP1 Gene

Protein Domains for DPEP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DPEP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16444

UniProtKB/Swiss-Prot:

DPEP1_HUMAN
Family:
  • Belongs to the peptidase M19 family.:
    • P16444
genes like me logo Genes that share domains with DPEP1: view

Function for DPEP1 Gene

Molecular function for DPEP1 Gene

GENATLAS Biochemistry: dipeptidase 1 (renal)
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of dipeptides.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by L-penicillamine.
UniProtKB/Swiss-Prot Function: Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity

Enzyme Numbers (IUBMB) for DPEP1 Gene

Gene Ontology (GO) - Molecular Function for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0008235 metalloexopeptidase activity TAS 2303490
GO:0008237 metallopeptidase activity --
GO:0008239 dipeptidyl-peptidase activity IEA --
GO:0008270 zinc ion binding IDA 19879002
genes like me logo Genes that share ontologies with DPEP1: view

Phenotypes for DPEP1 Gene

MGI mutant phenotypes for DPEP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with DPEP1: view

Animal Models for DPEP1 Gene

MGI Knock Outs for DPEP1:

miRNA for DPEP1 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for DPEP1 Gene

Localization for DPEP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPEP1 Gene

Apical cell membrane; Lipid-anchor, GPI-anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI-anchor. Note=Brush border membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPEP1 Gene COMPARTMENTS Subcellular localization image for DPEP1 gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005634 nucleus IDA --
GO:0005886 plasma membrane TAS 20031578
GO:0016324 apical plasma membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with DPEP1: view

Pathways for DPEP1 Gene

genes like me logo Genes that share pathways with DPEP1: view

Interacting Proteins for DPEP1 Gene

Gene Ontology (GO) - Biological Process for DPEP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006691 leukotriene metabolic process TAS --
GO:0006749 glutathione metabolic process TAS 20031578
GO:0006805 xenobiotic metabolic process TAS --
GO:0016999 antibiotic metabolic process IDA 8737157
genes like me logo Genes that share ontologies with DPEP1: view

Compounds for DPEP1 Gene

(2) HMDB Compounds for DPEP1 Gene

Compound Synonyms Cas Number PubMed IDs
10,11-Dihydro-12R-hydroxy-leukotriene E4
  • 5,12-dihydroxy-6-cysteinyl-7,9,14-eicosatrienoate
Not Available
Zinc
  • Zinc
7440-66-6

(1) Drugbank Compounds for DPEP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cilastatin
82009-34-5 target inhibitor

(1) IUPHAR Ligand for DPEP1 Gene

Ligand Type Action Affinity Pubmed IDs
cilastatin Inhibitor Inhibition

(29) Novoseek inferred chemical compound relationships for DPEP1 Gene

Compound -log(P) Hits PubMed IDs
isoglutamine 86.6 2
muramyl tripeptide phosphatidylethanolamine 82.4 4
romurtide 81 8
cilastatin 78.4 9
murabutide 73.6 4
genes like me logo Genes that share compounds with DPEP1: view

Transcripts for DPEP1 Gene

Unigene Clusters for DPEP1 Gene

Dipeptidase 1 (renal):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPEP1 Gene

No ASD Table

Relevant External Links for DPEP1 Gene

GeneLoc Exon Structure for
DPEP1
ECgene alternative splicing isoforms for
DPEP1

Expression for DPEP1 Gene

mRNA expression in normal human tissues for DPEP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DPEP1 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (19.2), Pancreas (15.8), and Kidney - Cortex (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPEP1 Gene

SOURCE GeneReport for Unigene cluster for DPEP1 Gene Hs.109

genes like me logo Genes that share expressions with DPEP1: view

No data available for mRNA Expression by UniProt/SwissProt for DPEP1 Gene

Orthologs for DPEP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DPEP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPEP1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPEP1 35
  • 84.1 (n)
  • 81.54 (a)
DPEP1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPEP1 35
  • 82.03 (n)
  • 77.8 (a)
DPEP1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpep1 35
  • 76.6 (n)
  • 72.91 (a)
Dpep1 16
Dpep1 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPEP1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPEP1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpep1 35
  • 77.42 (n)
  • 74.38 (a)
chicken
(Gallus gallus)
Aves DPEP1 35
  • 71.32 (n)
  • 67.11 (a)
DPEP1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPEP1 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpep1 35
  • 61.43 (n)
  • 62.34 (a)
zebrafish
(Danio rerio)
Actinopterygii dpep1 35
  • 61 (n)
  • 60.31 (a)
dpep1 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002634 35
  • 57.18 (n)
  • 51.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34420 36
  • 19 (a)
ManyToMany
CG42750 36
  • 14 (a)
ManyToMany
CG5282 36
  • 22 (a)
ManyToMany
CG6154 35
  • 57.63 (n)
  • 50.68 (a)
CG6154 36
  • 41 (a)
ManyToMany
CG5917 37
  • 44 (a)
CG5282 37
  • 28 (a)
CG6154 37
  • 51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09538 35
  • 54.38 (n)
  • 46.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3A11.10c 35
  • 47.73 (n)
  • 45.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
Species with no ortholog for DPEP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPEP1 Gene

ENSEMBL:
Gene Tree for DPEP1 (if available)
TreeFam:
Gene Tree for DPEP1 (if available)

Paralogs for DPEP1 Gene

Paralogs for DPEP1 Gene

Selected SIMAP similar genes for DPEP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DPEP1: view

Variants for DPEP1 Gene

Sequence variations from dbSNP and Humsavar for DPEP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs154665 -- 89,624,280(-) GCCAC(A/G)CTTCC intron-variant
rs164741 -- 89,625,890(-) ACCAC(C/T)GTTCA intron-variant
rs164750 -- 89,641,245(-) ggaag(A/G)tctga downstream-variant-500B
rs164751 -- 89,641,228(-) tcaac(A/C)ccccc downstream-variant-500B
rs185423 -- 89,627,714(+) ggagt(A/G)cagtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPEP1 Gene

Variant ID Type Subtype PubMed ID
nsv907357 CNV Loss 21882294
nsv428331 CNV Gain+Loss 18775914
dgv3008n71 CNV Loss 21882294
dgv3009n71 CNV Loss 21882294
nsv509639 CNV Insertion 20534489
dgv3010n71 CNV Loss 21882294
nsv1929 CNV Insertion 18451855
esv2715182 CNV Deletion 23290073
nsv103438 CNV Loss 16902084
nsv907419 CNV Gain 21882294
esv1242032 CNV Insertion 17803354
esv24216 CNV Loss 19812545
esv1355826 CNV Insertion 17803354
nsv907420 CNV Loss 21882294
nsv907421 CNV Loss 21882294
esv7562 CNV Gain 19470904
nsv1930 CNV Insertion 18451855
esv2715183 CNV Deletion 23290073
esv2676847 CNV Deletion 23128226
esv2715184 CNV Deletion 23290073
esv2715186 CNV Deletion 23290073
esv2715187 CNV Deletion 23290073
esv2715188 CNV Deletion 23290073

Relevant External Links for DPEP1 Gene

HapMap Linkage Disequilibrium report
DPEP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPEP1 Gene

Disorders for DPEP1 Gene

(1) University of Copenhagen DISEASES for DPEP1 Gene

(17) Novoseek inferred disease relationships for DPEP1 Gene

Disease -log(P) Hits PubMed IDs
blau syndrome 85.4 1
gram-positive bacterial infections 56.5 1
necrosis 40.7 13
bacterial infections 32.1 3
inflammation 30.8 10

Relevant External Links for DPEP1

Genetic Association Database (GAD)
DPEP1
Human Genome Epidemiology (HuGE) Navigator
DPEP1
genes like me logo Genes that share disorders with DPEP1: view

No data available for UniProtKB/Swiss-Prot for DPEP1 Gene

Publications for DPEP1 Gene

  1. Importance of Glu-125 in the catalytic activity of human renal dipeptidase. (PMID: 8097406) Adachi H. … Tsujimoto M. (Biochim. Biophys. Acta 1993) 3 4 23
  2. Primary structure of human microsomal dipeptidase deduced from molecular cloning. (PMID: 2303490) Adachi H. … Nakazato H. (J. Biol. Chem. 1990) 3 4 23
  3. Gene structural analysis and expression of human renal dipeptidase. (PMID: 7764673) Satoh S. … Kohsaka M. (Biotechnol. Prog. 1994) 3 4 23
  4. Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. (PMID: 12144777) Nitanai Y. … Tsujimoto M. (J. Mol. Biol. 2002) 3 4 23
  5. Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme. (PMID: 2137335) Hooper N.M. … Turner A.J. (Biochem. J. 1990) 3 4 23

Products for DPEP1 Gene

Sources for DPEP1 Gene

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