DPCD Gene
protein-coding GIFtS: 46
GCID: GC10P103338
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deleted in primary ciliary dyskinesia homolog (mouse)
| |
Aliases
for DPCD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Deleted In Primary Ciliary Dyskinesia Homolog (Mouse)1 2 | | DKFZP566F0841 | | RP11-529I10.41 | | Deleted In A Mouse Model Of Primary Ciliary Dyskinesia2 | | Protein DPCD2 |
Export aliases for DPCD gene to outside databasesPrevious GC identifers: GC10U900371 GC10P103014 GC10P096978 |
Summaries
for DPCD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DPCD_HUMAN, Q9BVM2Function: May play a role in the formation or function of ciliated cells
|
Genomic Views
for DPCD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DPCD
Other transcription factors
Search SABiosciences Chromatin IP Primers for DPCD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPCD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.32 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.32DPCD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P103338: view genomic region
(about GC identifiers)
Start:
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103,330,317 bp from pter |
End:
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103,369,425 bp from pter |
Size:
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39,109 bases |
Orientation:
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plus strand |
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Proteins
for DPCD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPCD_HUMAN, Q9BVM2 (See
protein sequence)Recommended Name: Protein DPCD Size: 203 amino acids; 23240 Da
Secondary accessions: A8K289 Q6QNL3 Q8N5R1 Q9UFY6Explore the universe of human proteins at neXtProt for DPCD: NX_Q9BVM2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BVM2
DPCD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056263.1
ENSEMBL proteins: ENSP00000359170 ENSP00000359166 ENSP00000403505 ENSP00000412584 ENSP00000359167
Human Recombinant Protein Products:
DPCD Antibody Products:
Assay Products for DPCD: |
Protein
Domains /
Families
for DPCD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DPCD for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BVM2ProtoNet protein and cluster: Q9BVM2 UniProtKB/Swiss-Prot: DPCD_HUMAN, Q9BVM2Similarity: Belongs to the DPCD family |
Function
for DPCD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DPCD_HUMAN, Q9BVM2Function: May play a role in the formation or function of ciliated cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPCD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPCD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DPCD (NM_015448) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPCD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPCD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPCD |
Animal Models:
Mouse knock-out Dpcd/PollDpcd/tm1Nmt for DPCD
11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dpcd):
DPCD for phenotypes About GeneDecksing
|
Pathways & Interactions
for DPCD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DPCD
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for DPCD (Q9BVM21, 3 ENSP000003591704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003351 | epithelial cilium movement |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0007368 | determination of left/right symmetry |
IEA | -- | | GO:0021670 | lateral ventricle development |
IEA | -- | | GO:0021678 | third ventricle development |
IEA | -- |
DPCD for ontologies About GeneDecksing
|
Drugs & Compounds
for DPCD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DPCD
Search CenterWatch for drugs/clinical trials and news about DPCD
|
Transcripts
for DPCD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DPCD gene: NM_015448.1 Unigene Cluster for DPCD: Deleted in primary ciliary dyskinesia homolog (mouse) Hs.658128 [show with all ESTs]Unigene Representative Sequence: BM4659967 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000470165 ENST00000370151(uc001ktn.3) ENST00000370147 ENST00000434727
ENST00000475443 ENST00000416979(uc010qpz.2) ENST00000370148
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPCD (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPCD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DPCD (NM_015448) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DPCD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPCD |
Additional cDNA sequence: AK290154.1 AL110240.1 AY532267.1 BC001082.2 BC031695.1 6 DOTS entries: DT.442740 DT.101968564 DT.92421058 DT.121285908 DT.121285912 DT.92009711 24/114 AceView cDNA sequences (see all 114): AA888039 BU681755 AI023680 BM980799 AI344430 BC031695 AI131397 BU507106 NM_015448 AI076168 AA745760 BM852366 AA773458 BQ637020 AJ573821 BM846167 AA746028 BM782340 AA503203 AI038327 BM726849 CD513597 BM907226 BC001082
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DPCD About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for DPCD
|
Expression
for DPCD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DPCD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCATATTTC
About this image
See DPCD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DPCD
SOURCE GeneReport for Unigene cluster: Hs.658128
UniProtKB/Swiss-Prot: DPCD_HUMAN, Q9BVM2Tissue specificity: Highly expressed in the testis. Weakly expressed in pancreas, skeletal muscle and heart. Expressionincreases during ciliated cell differentiation
SABiosciences Custom PCR Arrays for DPCD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPCD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DPCD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPCD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPCD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPCD |
Orthologs
for DPCD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DPCD gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for DPCD (if available)
TreeFam Gene Tree for DPCD (if available) |
Paralogs
for DPCD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DPCD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DPCD (103330317 - 103369425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DPCD
1 CNV: 8666
1 Indel: 65774 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DPCD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DPCD for disorders About GeneDecksing
4  diseases for DPCD: About MalaCardsprimary ciliary dyskinesia ciliary dyskinesia situs inversus alzheimer's disease
2 diseases from the University of Copenhagen DISEASES database for DPCD:Primary ciliary dyskinesia Situs inversus Human Genome Epidemiology (HuGE) Navigator: DPCD (0 documents)
Export disorders for DPCD gene to outside databases
|
Publications
for DPCD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DPCD gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with DPCD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia. (PubMed id 14630615)1, 2, 3 Zariwala M....Ostrowski L.E. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
|
External Searches for DPCD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DPCD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DPCD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DPCD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DPCD | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DPCD gene:
Search GeneIP for patents involving DPCD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DPCD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for DPCD | | OriGene shRNA RFP for DPCD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DPCD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DPCD | | | OriGene Protein Over-expression Lysate for DPCD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DPCD | | OriGene 3'-UTR Clone for DPCD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DPCD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DPCD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DPCD | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DPCD | | OriGene Custom Protein Services for DPCD | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DPCD | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DPCD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DPCD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DPCD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DPCD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DPCD |
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| | | | Search Tocris compounds for DPCD |
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 | | | DPCD Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DPCD |
|  |  |  | | | | ThermoFisher Antibodies for DPCD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DPCD |
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