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Aliases for DPCD Gene

Aliases for DPCD Gene

  • Deleted In Primary Ciliary Dyskinesia Homolog (Mouse) 2 3 5
  • Deleted In A Mouse Model Of Primary Ciliary Dyskinesia 3
  • RP11-529I10.4 3
  • Protein DPCD 3

External Ids for DPCD Gene

Previous GeneCards Identifiers for DPCD Gene

  • GC10U900371
  • GC10P103014
  • GC10P103338
  • GC10P096978

Summaries for DPCD Gene

Entrez Gene Summary for DPCD Gene

  • This gene in mouse encodes a protein that may be involved in the generation and maintenance of ciliated cells. In mouse, expression of this gene increases during ciliated cell differentiation, and disruption of this gene has been linked to primary ciliary dyskinesia. [provided by RefSeq, Jul 2016]

GeneCards Summary for DPCD Gene

DPCD (Deleted In Primary Ciliary Dyskinesia Homolog (Mouse)) is a Protein Coding gene. Diseases associated with DPCD include Primary Ciliary Dyskinesia and Visceral Heterotaxy.

UniProtKB/Swiss-Prot for DPCD Gene

  • May play a role in the formation or function of ciliated cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPCD Gene

Genomics for DPCD Gene

Regulatory Elements for DPCD Gene

Enhancers for DPCD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DPCD on UCSC Golden Path with GeneCards custom track

Promoters for DPCD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DPCD Gene

Chromosome:
10
Start:
101,570,560 bp from pter
End:
101,609,668 bp from pter
Size:
39,109 bases
Orientation:
Plus strand

Genomic View for DPCD Gene

Genes around DPCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DPCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DPCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPCD Gene

Proteins for DPCD Gene

  • Protein details for DPCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVM2-DPCD_HUMAN
    Recommended name:
    Protein DPCD
    Protein Accession:
    Q9BVM2
    Secondary Accessions:
    • A8K289
    • Q6QNL3
    • Q8N5R1
    • Q9UFY6

    Protein attributes for DPCD Gene

    Size:
    203 amino acids
    Molecular mass:
    23240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DPCD Gene

Post-translational modifications for DPCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DPCD Gene

Domains & Families for DPCD Gene

Protein Domains for DPCD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DPCD Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVM2

UniProtKB/Swiss-Prot:

DPCD_HUMAN :
  • Belongs to the DPCD family.
Family:
  • Belongs to the DPCD family.
genes like me logo Genes that share domains with DPCD: view

No data available for Gene Families for DPCD Gene

Function for DPCD Gene

Molecular function for DPCD Gene

UniProtKB/Swiss-Prot Function:
May play a role in the formation or function of ciliated cells.

Gene Ontology (GO) - Molecular Function for DPCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DPCD: view
genes like me logo Genes that share phenotypes with DPCD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DPCD Gene

Localization for DPCD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPCD Gene COMPARTMENTS Subcellular localization image for DPCD gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DPCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with DPCD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DPCD Gene

Pathways & Interactions for DPCD Gene

SuperPathways for DPCD Gene

No Data Available

Gene Ontology (GO) - Biological Process for DPCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0007283 spermatogenesis IEA --
GO:0007368 determination of left/right symmetry IEA --
GO:0021591 ventricular system development IEA --
GO:0021670 lateral ventricle development IEA --
genes like me logo Genes that share ontologies with DPCD: view

No data available for Pathways by source and SIGNOR curated interactions for DPCD Gene

Drugs & Compounds for DPCD Gene

No Compound Related Data Available

Transcripts for DPCD Gene

Unigene Clusters for DPCD Gene

Deleted in primary ciliary dyskinesia homolog (mouse):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPCD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for DPCD Gene

GeneLoc Exon Structure for
DPCD
ECgene alternative splicing isoforms for
DPCD

Expression for DPCD Gene

mRNA expression in normal human tissues for DPCD Gene

mRNA differential expression in normal tissues according to GTEx for DPCD Gene

This gene is overexpressed in Testis (x5.9).

Protein differential expression in normal tissues from HIPED for DPCD Gene

This gene is overexpressed in Testis (13.3), Ovary (8.4), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DPCD Gene



Protein tissue co-expression partners for DPCD Gene

NURSA nuclear receptor signaling pathways regulating expression of DPCD Gene:

DPCD

SOURCE GeneReport for Unigene cluster for DPCD Gene:

Hs.658128

mRNA Expression by UniProt/SwissProt for DPCD Gene:

Q9BVM2-DPCD_HUMAN
Tissue specificity: Highly expressed in the testis. Weakly expressed in pancreas, skeletal muscle and heart. Expression increases during ciliated cell differentiation.
genes like me logo Genes that share expression patterns with DPCD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DPCD Gene

Orthologs for DPCD Gene

This gene was present in the common ancestor of animals.

Orthologs for DPCD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DPCD 34
  • 88.01 (n)
  • 88.67 (a)
DPCD 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPCD 34
  • 90.15 (n)
  • 91.13 (a)
DPCD 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpcd 34
  • 86.54 (n)
  • 88.18 (a)
Dpcd 16
Dpcd 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DPCD 34
  • 94.25 (n)
  • 93 (a)
DPCD 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPCD 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPCD 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves DPCD 34
  • 73.07 (n)
  • 70.44 (a)
DPCD 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DPCD 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpcd 34
  • 66.17 (n)
  • 70.44 (a)
Str.10966 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8292 34
zebrafish
(Danio rerio)
Actinopterygii dpcd 34
  • 61.33 (n)
  • 63 (a)
dpcd 35
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012517 34
  • 45.67 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13901 34
  • 51.1 (n)
  • 41.62 (a)
CG13901 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1143 35
  • 49 (a)
OneToOne
Species where no ortholog for DPCD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPCD Gene

ENSEMBL:
Gene Tree for DPCD (if available)
TreeFam:
Gene Tree for DPCD (if available)

Paralogs for DPCD Gene

No data available for Paralogs for DPCD Gene

Variants for DPCD Gene

Sequence variations from dbSNP and Humsavar for DPCD Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_039574 -
rs7006 - 101,608,897(-) TCAGC(A/G)AGGCG reference, missense
rs3127254 -- 101,596,566(+) TTCTT(G/T)TCTTC intron-variant
rs3915773 -- 101,607,080(-) GGGCT(G/T)GGCCA intron-variant
rs3924011 -- 101,592,941(-) tgcct(C/T)ccggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPCD Gene

Variant ID Type Subtype PubMed ID
esv23858 CNV loss 19812545
esv2677024 CNV deletion 23128226
esv2750847 CNV gain 17911159
esv3624382 CNV gain 21293372
esv3624385 CNV loss 21293372
nsv1053934 CNV gain 25217958
nsv526529 CNV loss 19592680
nsv527185 CNV loss 19592680

Variation tolerance for DPCD Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DPCD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DPCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPCD Gene

Disorders for DPCD Gene

MalaCards: The human disease database

(2) MalaCards diseases for DPCD Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • kartagener syndrome
visceral heterotaxy
  • heterotaxia
- elite association - COSMIC cancer census association via MalaCards
Search DPCD in MalaCards View complete list of genes associated with diseases

Relevant External Links for DPCD

Human Genome Epidemiology (HuGE) Navigator
DPCD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DPCD
genes like me logo Genes that share disorders with DPCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DPCD Gene

Publications for DPCD Gene

  1. Investigation of the possible role of a novel gene, DPCD, in primary ciliary dyskinesia. (PMID: 14630615) Zariwala M. … Ostrowski L.E. (Am. J. Respir. Cell Mol. Biol. 2004) 2 3 4 65
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3 65
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 65

Products for DPCD Gene

Sources for DPCD Gene

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