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Aliases for DPAGT1 Gene

Aliases for DPAGT1 Gene

  • Dolichyl-Phosphate (UDP-N-Acetylglucosamine) N-Acetylglucosaminephosphotransferase 1 (GlcNAc-1-P Transferase) 2 3
  • DPAGT2 3 4 6
  • N-Acetylglucosamine-1-Phosphate Transferase 3 4
  • GlcNAc-1-P Transferase 3 4
  • EC 4 63
  • CMSTA2 3 6
  • CDG1J 3 6
  • DGPT 3 6
  • G1PT 3 4
  • GPT 3 4
  • Dolichyl-Phosphate (UDP-N-Acetylglucosamine) N-Acetylglucosaminephosphotransferase 1 (GlcNAc-1-P Tra 3
  • UDP-N-Acetylglucosamine--Dolichyl-Phosphate N-Acetylglucosaminephosphotransferase 3
  • UDP-GlcNAc:Dolichyl-Phosphate N-Acetylglucosaminephosphotransferase 3
  • Dolichyl-Phosphate Alpha-N-Acetylglucosaminyltransferase 3
  • EC 2.7.8 63
  • D11S366 3
  • CDG-Ij 3
  • DPAGT 3
  • UGAT 3
  • ALG7 3
  • UAGT 3

External Ids for DPAGT1 Gene

Previous HGNC Symbols for DPAGT1 Gene

  • DPAGT2

Previous GeneCards Identifiers for DPAGT1 Gene

  • GC11M135549
  • GC11M120479
  • GC11M119001
  • GC11M118504
  • GC11M118472
  • GC11M114906
  • GC11M118973

Summaries for DPAGT1 Gene

Entrez Gene Summary for DPAGT1 Gene

  • The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPAGT1 Gene

DPAGT1 (Dolichyl-Phosphate (UDP-N-Acetylglucosamine) N-Acetylglucosaminephosphotransferase 1 (GlcNAc-1-P Transferase)) is a Protein Coding gene. Diseases associated with DPAGT1 include congenital disorder of glycosylation, type ij and myasthenic syndrome, congenital, with tubular aggregates 2. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include transferase activity, transferring glycosyl groups and phospho-N-acetylmuramoyl-pentapeptide-transferase activity.

UniProtKB/Swiss-Prot for DPAGT1 Gene

  • Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides

Gene Wiki entry for DPAGT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPAGT1 Gene

Genomics for DPAGT1 Gene

Regulatory Elements for DPAGT1 Gene

Genomic Location for DPAGT1 Gene

119,096,503 bp from pter
119,108,331 bp from pter
11,829 bases
Minus strand

Genomic View for DPAGT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPAGT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPAGT1 Gene

Proteins for DPAGT1 Gene

  • Protein details for DPAGT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
    Protein Accession:
    Secondary Accessions:
    • O15216
    • Q86WV9
    • Q9BWE6

    Protein attributes for DPAGT1 Gene

    408 amino acids
    Molecular mass:
    46090 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DPAGT1 Gene


neXtProt entry for DPAGT1 Gene

Proteomics data for DPAGT1 Gene at MOPED

Post-translational modifications for DPAGT1 Gene

Other Protein References for DPAGT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for DPAGT1 Gene

Protein Domains for DPAGT1 Gene


Suggested Antigen Peptide Sequences for DPAGT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 4 family.
  • Belongs to the glycosyltransferase 4 family.
genes like me logo Genes that share domains with DPAGT1: view

No data available for Gene Families for DPAGT1 Gene

Function for DPAGT1 Gene

Molecular function for DPAGT1 Gene

GENATLAS Biochemistry:
dolichyl-phosphate alpha-N-acetylglucosamyltransferase (see D11S366)
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol
UniProtKB/Swiss-Prot Function:
Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides

Enzyme Numbers (IUBMB) for DPAGT1 Gene

Gene Ontology (GO) - Molecular Function for DPAGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IMP 12872255
GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with DPAGT1: view

Phenotypes for DPAGT1 Gene

MGI mutant phenotypes for DPAGT1:
inferred from 3 alleles
GenomeRNAi human phenotypes for DPAGT1:
genes like me logo Genes that share phenotypes with DPAGT1: view

Animal Models for DPAGT1 Gene

MGI Knock Outs for DPAGT1:

Animal Model Products

miRNA for DPAGT1 Gene

miRTarBase miRNAs that target DPAGT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPAGT1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DPAGT1 Gene

Localization for DPAGT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPAGT1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DPAGT1 Gene COMPARTMENTS Subcellular localization image for DPAGT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DPAGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 8179616
GO:0016021 integral component of membrane ISS --
GO:0030176 integral component of endoplasmic reticulum membrane NAS 12872255
GO:0043231 intracellular membrane-bounded organelle IDA 12872255
genes like me logo Genes that share ontologies with DPAGT1: view

Pathways for DPAGT1 Gene

genes like me logo Genes that share pathways with DPAGT1: view

UniProtKB/Swiss-Prot Q9H3H5-GPT_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for DPAGT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000271 polysaccharide biosynthetic process IBA --
GO:0006047 UDP-N-acetylglucosamine metabolic process IBA --
GO:0006487 protein N-linked glycosylation IMP 19549906
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with DPAGT1: view

Drugs for DPAGT1 Gene

(4) Drugbank Compounds for DPAGT1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
Carboxylic PRPP
46936838 Target experimental
73-40-5 764 Target experimental
85-32-5 5748251 Target experimental
69-89-6 1188 Target experimental

(5) HMDB Compounds for DPAGT1 Gene

Compound Synonyms Cas Number PubMed IDs
Dolichol phosphate
  • Dolichol monophosphate
  • Dolichol
  • N-Acetyl-D-glucosaminyl-diphosphodolichol
Uridine 5'-monophosphate
  • 5'-UMP
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-Dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide

(10) Novoseek inferred chemical compound relationships for DPAGT1 Gene

Compound -log(P) Hits PubMed IDs
glcnac-pp-dolichol 96.2 3
dolichol 78.9 4
mycophenolic acid 59.8 2
tunicamycin 57 4
6 thioguanine 46.3 1
genes like me logo Genes that share compounds with DPAGT1: view

Transcripts for DPAGT1 Gene

Unigene Clusters for DPAGT1 Gene

Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DPAGT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DPAGT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a ·
SP1: - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: -
SP9: - - -
SP10: - - - -

ExUns: 11b

Relevant External Links for DPAGT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DPAGT1 Gene

mRNA expression in normal human tissues for DPAGT1 Gene

Protein differential expression in normal tissues for DPAGT1 Gene

This gene is overexpressed in Liver (8.7), Cardia (7.2), Monocytes (6.6), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DPAGT1 Gene

SOURCE GeneReport for Unigene cluster for DPAGT1 Gene Hs.524081

genes like me logo Genes that share expressions with DPAGT1: view

Expression partners for DPAGT1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DPAGT1 Gene

Orthologs for DPAGT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPAGT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DPAGT1 35
  • 92.24 (n)
  • 93.63 (a)
  • 94 (a)
(Canis familiaris)
Mammalia DPAGT1 35
  • 92.57 (n)
  • 95.59 (a)
  • 96 (a)
(Mus musculus)
Mammalia Dpagt1 35
  • 89.95 (n)
  • 94.12 (a)
Dpagt1 16
Dpagt1 36
  • 94 (a)
(Pan troglodytes)
Mammalia DPAGT1 35
  • 99.84 (n)
  • 99.75 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dpagt1 35
  • 90.44 (n)
  • 93.63 (a)
(Monodelphis domestica)
Mammalia DPAGT1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia DPAGT1 36
  • 64 (a)
(Gallus gallus)
Aves DPAGT1 35
  • 75.69 (n)
  • 83.46 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia DPAGT1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487779 35
  • 73.73 (n)
  • 83.77 (a)
(Danio rerio)
Actinopterygii dpagt1 35
  • 69.55 (n)
  • 77.48 (a)
dpagt1 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5287 37
  • 55 (a)
CG5287 35
  • 58.82 (n)
  • 57.03 (a)
CG5287 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008131 35
  • 58.83 (n)
  • 56.25 (a)
(Caenorhabditis elegans)
Secernentea T08D2.2 37
  • 51 (a)
Y60A3A.14 37
  • 50 (a)
CELE_Y60A3A.14 35
  • 54.23 (n)
  • 52.79 (a)
T08D2.2 36
  • 46 (a)
Y60A3A.14 36
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL037W 35
  • 53.03 (n)
  • 45.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06776g 35
  • 50.09 (n)
  • 44.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG7 35
  • 50.36 (n)
  • 44.59 (a)
ALG7 36
  • 38 (a)
ALG7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G57220 35
  • 52.96 (n)
  • 51.71 (a)
(Oryza sativa)
Liliopsida Os07g0661100 35
  • 54.21 (n)
  • 48.82 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10762 35
  • 54.03 (n)
  • 46.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gpt2 35
  • 49 (n)
  • 47.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6031 36
  • 52 (a)
Species with no ortholog for DPAGT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DPAGT1 Gene

Gene Tree for DPAGT1 (if available)
Gene Tree for DPAGT1 (if available)

Paralogs for DPAGT1 Gene

No data available for Paralogs for DPAGT1 Gene

Variants for DPAGT1 Gene

Sequence variations from dbSNP and Humsavar for DPAGT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs565669 -- 119,103,411(-) CCTCA(C/T)ATCTG upstream-variant-2KB
rs599385 -- 119,103,775(+) ACAAA(A/G)ACCCA upstream-variant-2KB
rs603826 -- 119,100,168(-) CAATA(G/T)GCATA intron-variant
rs604714 -- 119,099,986(-) ACAGG(G/T)TCATT intron-variant
rs649870 -- 119,100,541(+) AGACA(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPAGT1 Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294

Relevant External Links for DPAGT1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPAGT1 Gene

Disorders for DPAGT1 Gene

(2) OMIM Diseases for DPAGT1 Gene (191350)


  • Congenital disorder of glycosylation 1J (CDG1J) [MIM:608093]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:12872255}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Myasthenic syndrome, congenital, with tubular aggregates, 2 (CMSTA2) [MIM:614750]: A congenital myasthenic syndrome characterized by muscle weakness mostly affecting proximal limb muscles, minimal involvement of facial, ocular and bulbar muscles, and tubular aggregates present on muscle biopsy. Symptoms include difficulty walking and frequent falls. Younger patients show hypotonia and poor head control. Neurophysiological features indicate a disorder of neuromuscular transmission on electromyography. {ECO:0000269 PubMed:22742743}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for DPAGT1 Gene

Disease -log(P) Hits PubMed IDs
smoking habit 14.2 2
bleeding 0 2

Relevant External Links for DPAGT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DPAGT1: view

No data available for Genatlas for DPAGT1 Gene

Publications for DPAGT1 Gene

  1. Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae. (PMID: 9451016) Eckert V. … Schwarz R.T. (Glycobiology 1998) 3 4 23
  2. Deficiency of UDP-GlcNAc:dolichol phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) causes a novel congenital disorder of glycosylation type Ij. (PMID: 12872255) Wu X. … Freeze H.H. (Hum. Mutat. 2003) 3 4 23
  3. Genomic structure of the human UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase gene. (PMID: 12592703) Regis S. … Filocamo M. (DNA Seq. 2002) 3 23
  4. Structure, expression, and regulation of UDP-GlcNAc: dolichol phosphate GlcNAc-1-phosphate transferase (DPAGT1). (PMID: 19519349) Bretthauer R.K. (Curr Drug Targets 2009) 3 23
  5. Major defect of carbohydrate-deficient-glycoprotein syndrome is not found in the synthesis of dolichyl phosphate or N-acetylglucosaminyl-pyrophosphoryl-dolichol. (PMID: 8179616) Yasugi E. … Oshima M. (Biochem. Biophys. Res. Commun. 1994) 3 23

Products for DPAGT1 Gene

Sources for DPAGT1 Gene

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