Aliases for DOT1L Gene
External Ids for DOT1L Gene
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
GeneCards Summary for DOT1L Gene
DOT1L (DOT1-Like Histone H3K79 Methyltransferase) is a Protein Coding gene. Among its related pathways are Transcriptional misregulation in cancer and Lysine degradation. GO annotations related to this gene include transcription factor binding and histone-lysine N-methyltransferase activity.
UniProtKB/Swiss-Prot for DOT1L Gene
Histone methyltransferase. Methylates Lys-79 of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA