DOT1L Gene
protein-coding GIFtS: 60
GCID: GC19P002115
|
|
DOT1-like, histone H3 methyltransferase (S. cerevisiae)
| |
Aliases
for DOT1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae)1 2 | | H3-K79-HMTase2 3 | | KMT41 2 3 | | DOT1-Like Protein2 3 | | DOT11 2 5 | | Histone Methyltransferase DOT1L2 | | KIAA18141 3 5 | | Histone-Lysine N-Methyltransferase, H3 Lysine-79 Specific2 | | Histone H3-K79 Methyltransferase2 3 | | EC 2.1.1.433 | | Lysine N-Methyltransferase 42 3 | | |
Export aliases for DOT1L gene to outside databasesPrevious GC identifers: GC19P002248 GC19P002104 GC19P001935 |
Summaries
for DOT1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DOT1L:
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactiveagainst free core histones, but shows significant histone methyltransferase activity against nucleosomes. (provided byRefSeq, Aug 2011)
UniProtKB/Swiss-Prot: DOT1L_HUMAN, Q8TEK3Function: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate comparedto free histones. Binds to DNA
Gene Wiki entry for DOT1L
|
Genomic Views
for DOT1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DOT1L gene promoter:
Sp1 GCNF NRSF form 1 MIF-1 NRSF form 2 GATA-2 FOXI1 GCNF-1 Pax-4a GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DOT1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOT1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3DOT1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P002115: view genomic region
(about GC identifiers)
Start:
|
2,164,148 bp from pter |
End:
|
2,232,577 bp from pter |
Size:
|
68,430 bases |
Orientation:
|
plus strand |
|
Proteins
for DOT1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DOT1L_HUMAN, Q8TEK3 (See
protein sequence)Recommended Name: Histone-lysine N-methyltransferase, H3 lysine-79 specific Size: 1739 amino acids; 184853 Da
Subunit: Interacts with MLLT10
Subcellular location: Nucleus (Probable)
Miscellaneous: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting theexistence of another mechanism for methylation of lysine residues of histones
Sequence caution: Sequence=AAC08316.1; Type=Erroneous gene model prediction;
6/15 PDB 3D structures from  and Proteopedia  for DOT1L (see all 15):1NW3 (3D)
3QOW (3D)
3QOX (3D)
3SR4 (3D)
3SX0 (3D)
3UWP (3D)
Secondary accessions: O60379 Q96JL1Alternative splicing: 2 isoforms: Q8TEK3-1 Q8TEK3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DOT1L: NX_Q8TEK3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TEK3
DOT1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115871.1
ENSEMBL proteins: ENSP00000381657 ENSP00000404284 ENSP00000388276 ENSP00000407411 ENSP00000412916
Human Recombinant Protein Products for DOT1L:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
DOT1L for ontologies About GeneDecksing
DOT1L Antibody Products:
Assay Products for DOT1L: |
Protein
Domains /
Families
for DOT1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DOT1L for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TEK3ProtoNet protein and cluster: Q8TEK3 UniProtKB/Swiss-Prot: DOT1L_HUMAN, Q8TEK3Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 familySimilarity: Contains 1 DOT1 domain |
Function
for DOT1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DOT1L_HUMAN, Q8TEK3Function: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate comparedto free histones. Binds to DNACatalytic activity: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine +N(6)-methyl-L-lysine-[histone] Enzyme Number (IUBMB): EC 2.1.1.431
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
DOT1L for ontologies About GeneDecksing
Phenotypes:
9 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Dot1l):
DOT1L for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Dot1ltm1.1Tche for DOT1L
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOT1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOT1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DOT1L (NM_032482) | |  | Sino Biological Human cDNA Clone for DOT1L | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOT1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOT1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOT1L |
|
Pathways & Interactions
for DOT1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Lysine degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for DOT1L):
DOT1L for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DOT1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/35 Interacting proteins for DOT1L (Q8TEK31, 2, 3 ENSP000003816574) via UniProtKB, MINT, STRING, and/or I2D (see all 35)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016571 | histone methylation |
-- | -- | | GO:0034968 | histone lysine methylation |
IDA | 17707234 | | GO:0046425 | regulation of JAK-STAT cascade |
IDA | -- | | GO:2000677 | regulation of transcription regulatory region DNA binding |
IMP | -- |
DOT1L for ontologies About GeneDecksing
|
Drugs & Compounds
for DOT1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DOT1L for compounds About GeneDecksing
 Browse Tocris compounds for DOT1L
3 HMDB Compounds for DOT1L About this table
1 Novoseek chemical compound relationship for DOT1L gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lysine |
58.4 |
2 |
14572310 (1), 18065378 (1) |
Search CenterWatch for drugs/clinical trials and news about DOT1L
|
Transcripts
for DOT1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DOT1L gene: NM_032482.2 Unigene Cluster for DOT1L: DOT1-like, histone H3 methyltransferase (S. cerevisiae) Hs.713641 [show with all ESTs]Unigene Representative Sequence: NM_03248211 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000398665(uc002lvb.4 uc002lvc.1) ENST00000478937 ENST00000452696
ENST00000592459 ENST00000440640 ENST00000591498 ENST00000586024 ENST00000472540
ENST00000482433(uc002lve.1) ENST00000457590 ENST00000446286
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOT1L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOT1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DOT1L (NM_032482) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOT1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOT1L |
Additional cDNA sequence: AB058717.1 AF509504.1 AK074120.1 AL080221.1 BC021037.1 BC032803.1 15 DOTS entries: DT.100024459 DT.99936606 DT.100749671 DT.310751 DT.121414401 DT.92418676 DT.95159594 DT.100001366 DT.100749670 DT.443785 DT.92033664 DT.95205123 DT.95219318 DT.100884259 DT.91967410 24/175 AceView cDNA sequences (see all 175): BU191550 BQ673798 BU948021 AL040709 BM725109 AA831699 CA433459 BM710320 BU623754 AB058717 BF343473 AF509504 CA433891 BM797557 BU180946 CB528521 BF507396 AK074120 BQ229264 AA310116 BU622332 AA584872 AI026903 BF982417
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DOT1L (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DOT1L
|
Expression
for DOT1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DOT1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCCGCCG
About this image
See DOT1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOT1L
SOURCE GeneReport for Unigene cluster: Hs.713641
SABiosciences Expression via Pathway-Focused PCR Array including DOT1L:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOT1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOT1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOT1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOT1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOT1L |
Orthologs
for DOT1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DOT1L gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for DOT1L (if available)
TreeFam Gene Tree for DOT1L (if available) |
Paralogs
for DOT1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DOT1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DOT1L (2164148 - 2232577 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DOT1L
2 CNVs: 5068 5067 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOT1L |
|
Disorders
/ Diseases
for DOT1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DOT1L for disorders About GeneDecksing
OMIM gene information: 607375
OMIM disorders: --
5  diseases for DOT1L: About MalaCardsaldosteronism homocysteine hepatocellular carcinoma carcinoma
leukemia
1 disease from the University of Copenhagen DISEASES database for DOT1L:Leukemia Human Genome Epidemiology (HuGE) Navigator: DOT1L (3 documents)
Export disorders for DOT1L gene to outside databases
|
Publications
for DOT1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DOT1L gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with DOT1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. (PubMed id 12123582)1, 2, 3 Feng Q....Zhang Y. (2002)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (2001)
- Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase. (PubMed id 12628190)1, 2, 9 Min J.... Xu R.-M. (2003)
- hDOT1L links histone methylation to leukemogenesis. (PubMed id 15851025)1, 2 Okada Y.... Zhang Y. (2005)
- Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones. (PubMed id 12693554)1, 2 Jikuya H....Ohara O. (2003)
- Characterization of the DOT1L network: implications o f diverse roles for DOT1L. (PubMed id 20431927)1, 9 Park G....Kim J.E. (2010)
- Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). (PubMed id 20203130)1, 9 Mohan M....Shilatifard A. (2010)
- Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upo n DNA demethylation. (PubMed id 19734945)1, 9 Jacinto F.V....Esteller M. (2009)
- Genome-wide association and functional studies identif y the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. (PubMed id 22566624)1 Castano Betancourt M.C....van Meurs J.B. (2012)
- Histone monoubiquitylation position determines specifi city and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2. (PubMed id 22619169)1 Whitcomb S.J....Allis C.D. (2012)
|
External Searches for DOT1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DOT1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DOT1L gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DOT1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DOT1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DOT1L gene:
Search GeneIP for patents involving DOT1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DOT1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DOT1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOT1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOT1L | | | OriGene Protein Over-expression Lysate for DOT1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DOT1L | | OriGene 3'-UTR Clone for DOT1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOT1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOT1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DOT1L | | OriGene Custom Protein Services for DOT1L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOT1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOT1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOT1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOT1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOT1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOT1L |
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| | | | Search Tocris compounds for DOT1L |
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 | | | DOT1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOT1L |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DOT1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOT1L |
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