Aliases for DOT1L Gene
External Ids for DOT1L Gene
Previous GeneCards Identifiers for DOT1L Gene
The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011]
GeneCards Summary for DOT1L Gene
DOT1L (DOT1 Like Histone H3K79 Methyltransferase) is a Protein Coding gene. Diseases associated with DOT1L include epididymo-orchitis and diffuse gastric cancer. Among its related pathways are Lysine degradation and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor binding and histone methyltransferase activity.
UniProtKB/Swiss-Prot for DOT1L Gene
Histone methyltransferase. Methylates Lys-79 of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.