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Aliases for DOPEY2 Gene

Aliases for DOPEY2 Gene

  • Dopey Family Member 2 2 3 5
  • C21orf5 3 4
  • Chromosome 21 Open Reading Frame 5 2
  • Homolog Of Yeast DOP1 3
  • KIAA0933 4
  • 21orf5 3

External Ids for DOPEY2 Gene

Previous HGNC Symbols for DOPEY2 Gene

  • C21orf5

Previous GeneCards Identifiers for DOPEY2 Gene

  • GC21P036459
  • GC21P037529
  • GC21P023014

Summaries for DOPEY2 Gene

GeneCards Summary for DOPEY2 Gene

DOPEY2 (Dopey Family Member 2) is a Protein Coding gene. Diseases associated with DOPEY2 include Down Syndrome. An important paralog of this gene is DOPEY1.

UniProtKB/Swiss-Prot for DOPEY2 Gene

  • May be involved in protein traffic between late Golgi and early endosomes.

Gene Wiki entry for DOPEY2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOPEY2 Gene

Genomics for DOPEY2 Gene

Regulatory Elements for DOPEY2 Gene

Enhancers for DOPEY2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DOPEY2 on UCSC Golden Path with GeneCards custom track

Promoters for DOPEY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOPEY2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DOPEY2 Gene

36,156,782 bp from pter
36,294,274 bp from pter
137,493 bases
Plus strand

Genomic View for DOPEY2 Gene

Genes around DOPEY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOPEY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOPEY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOPEY2 Gene

Proteins for DOPEY2 Gene

  • Protein details for DOPEY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein dopey-2
    Protein Accession:
    Secondary Accessions:
    • D3DSG5
    • Q6PJQ7
    • Q9UEZ3

    Protein attributes for DOPEY2 Gene

    2298 amino acids
    Molecular mass:
    258230 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DOPEY2 Gene


neXtProt entry for DOPEY2 Gene

Proteomics data for DOPEY2 Gene at MOPED

Post-translational modifications for DOPEY2 Gene

  • Ubiquitination at Lys 23 and Lys 420
  • Modification sites at PhosphoSitePlus

Other Protein References for DOPEY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DOPEY2 Gene

Domains & Families for DOPEY2 Gene

Protein Domains for DOPEY2 Gene


Suggested Antigen Peptide Sequences for DOPEY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dopey family.
  • Belongs to the dopey family.
genes like me logo Genes that share domains with DOPEY2: view

No data available for Gene Families for DOPEY2 Gene

Function for DOPEY2 Gene

Molecular function for DOPEY2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein traffic between late Golgi and early endosomes.
genes like me logo Genes that share phenotypes with DOPEY2: view

Animal Models for DOPEY2 Gene

MGI Knock Outs for DOPEY2:

Animal Model Products

miRNA for DOPEY2 Gene

miRTarBase miRNAs that target DOPEY2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOPEY2 Gene

Localization for DOPEY2 Gene

Subcellular locations from

Jensen Localization Image for DOPEY2 Gene COMPARTMENTS Subcellular localization image for DOPEY2 gene
Compartment Confidence
extracellular 5
golgi apparatus 3
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DOPEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS 16301316
genes like me logo Genes that share ontologies with DOPEY2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOPEY2 Gene

Pathways & Interactions for DOPEY2 Gene

SuperPathways for DOPEY2 Gene

No Data Available

Interacting Proteins for DOPEY2 Gene

Gene Ontology (GO) - Biological Process for DOPEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport ISS 16301316
GO:0007029 endoplasmic reticulum organization ISS 16301316
genes like me logo Genes that share ontologies with DOPEY2: view

No data available for Pathways by source and SIGNOR curated interactions for DOPEY2 Gene

Drugs & Compounds for DOPEY2 Gene

No Compound Related Data Available

Transcripts for DOPEY2 Gene

Unigene Clusters for DOPEY2 Gene

Dopey family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOPEY2 Gene

No ASD Table

Relevant External Links for DOPEY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOPEY2 Gene

mRNA expression in normal human tissues for DOPEY2 Gene

Protein differential expression in normal tissues from HIPED for DOPEY2 Gene

This gene is overexpressed in Bone (37.3) and Salivary gland (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOPEY2 Gene

SOURCE GeneReport for Unigene cluster for DOPEY2 Gene Hs.204575

mRNA Expression by UniProt/SwissProt for DOPEY2 Gene

Tissue specificity: Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients.
genes like me logo Genes that share expression patterns with DOPEY2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for DOPEY2 Gene

Orthologs for DOPEY2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOPEY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DOPEY2 35
  • 83.44 (n)
  • 86.31 (a)
  • 85 (a)
(Canis familiaris)
Mammalia DOPEY2 35
  • 87.41 (n)
  • 90.07 (a)
  • 80 (a)
(Mus musculus)
Mammalia Dopey2 35
  • 83.1 (n)
  • 86.57 (a)
Dopey2 16
Dopey2 36
  • 86 (a)
(Pan troglodytes)
Mammalia DOPEY2 35
  • 99.48 (n)
  • 99.74 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dopey2 35
  • 83.24 (n)
  • 86.44 (a)
(Monodelphis domestica)
Mammalia DOPEY2 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia DOPEY2 36
  • 74 (a)
(Gallus gallus)
Aves DOPEY2 35
  • 71.57 (n)
  • 76.33 (a)
gga-mir-7452 36
  • 75 (a)
(Anolis carolinensis)
Reptilia DOPEY2 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dopey2 35
  • 68.14 (n)
  • 70.83 (a)
(Danio rerio)
Actinopterygii zgc63622 35
dopey2 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15099 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea pad-1 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOP1 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
-- 36
  • 25 (a)
Species with no ortholog for DOPEY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOPEY2 Gene

Gene Tree for DOPEY2 (if available)
Gene Tree for DOPEY2 (if available)

Paralogs for DOPEY2 Gene

Paralogs for DOPEY2 Gene

(1) SIMAP similar genes for DOPEY2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DOPEY2: view

Variants for DOPEY2 Gene

Sequence variations from dbSNP and Humsavar for DOPEY2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs4817788 - 36,245,332(+) GCTCC(A/G/T)GCCAC nc-transcript-variant, reference, missense
rs3746866 - 36,245,426(+) CATCC(A/C)CATGG nc-transcript-variant, reference, missense
rs3746867 - 36,245,631(+) GAAAG(G/T)CAGGA nc-transcript-variant, reference, missense
rs3827183 - 36,289,107(+) AGTGG(A/G)GGAGA nc-transcript-variant, reference, missense
rs7278340 - 36,239,950(+) GAACT(C/G/T)GGCCG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DOPEY2 Gene

Variant ID Type Subtype PubMed ID
esv2751927 CNV Gain 17911159
esv2751928 CNV Gain 17911159
esv33578 CNV Loss 17666407
nsv459249 CNV Gain 19166990
nsv516175 CNV Gain 19592680
esv2456821 CNV Deletion 19546169
nsv510797 CNV Loss 20534489
nsv913734 CNV Gain 21882294
esv2723391 CNV Deletion 23290073
esv2670565 CNV Deletion 23128226

Variation tolerance for DOPEY2 Gene

Residual Variation Intolerance Score: 71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.97; 91.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DOPEY2 Gene

Disorders for DOPEY2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DOPEY2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
down syndrome
  • complete trisomy 21 syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DOPEY2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DOPEY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOPEY2 Gene

Publications for DOPEY2 Gene

  1. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. (PMID: 10931277) Pascon R.C. … Miller B.L. (Mol. Microbiol. 2000) 2 3 4 67
  2. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham A.K. … Munro S. (J. Biol. Chem. 2006) 2 3
  3. C21orf5, a new member of Dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in Down syndrome. (PMID: 16303751) Rachidi M. … Delabar J.M. (DNA Res. 2005) 2 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for DOPEY2 Gene

Sources for DOPEY2 Gene