DOPEY2 Gene
protein-coding GIFtS: 45
GCID: GC21P037529
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|
dopey family member 2(Previous name: chromosome 21 open reading frame 5 )
(Previous symbol: C21orf5)
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Aliases
for DOPEY2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dopey Family Member 21 2 | | Chromosome 21 Open Reading Frame 51 | | C21orf51 2 3 | | Homolog Of Yeast DOP12 | | KIAA09331 3 5 | | Protein Dopey-22 | | 21orf52 5 | | |
Export aliases for DOPEY2 gene to outside databasesPrevious GC identifers: GC21P036459 GC21P023014 |
Summaries
for DOPEY2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DOP2_HUMAN, Q9Y3R5Function: May be involved in protein traffic between late Golgi and early endosomes (By similarity)
Gene Wiki entry for DOPEY2
|
Genomic Views
for DOPEY2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DOPEY2 gene promoter:
RP58 AML1a NCX/Ncx FOXD1 E47 AREB6 PPAR-gamma1 COMP1 PPAR-gamma2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for DOPEY2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOPEY2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.2 Ensembl cytogenetic band: 21q22.12 HGNC cytogenetic band: 21q22.2DOPEY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P037529: view genomic region
(about GC identifiers)
Start:
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37,529,080 bp from pter |
End:
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37,711,195 bp from pter |
Size:
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182,116 bases |
Orientation:
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plus strand |
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Proteins
for DOPEY2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DOP2_HUMAN, Q9Y3R5 (See
protein sequence)Recommended Name: Protein dopey-2 Size: 2298 amino acids; 258230 Da
Developmental stage: Abundantly expressed in developing central nervous system, with highest levels in cerebellum andlowest in telencephalon
Secondary accessions: D3DSG5 Q6PJQ7 Q9UEZ3Alternative splicing: 2 isoforms: Q9Y3R5-1 Q9Y3R5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DOPEY2: NX_Q9Y3R5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3R5
DOPEY2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005119.2
ENSEMBL proteins: ENSP00000270190 ENSP00000382104 ENSP00000393528 ENSP00000389477 ENSP00000411059 ENSP00000413506
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
DOPEY2 for ontologies About GeneDecksing
DOPEY2 Antibody Products:
Assay Products for DOPEY2: |
Protein
Domains /
Families
for DOPEY2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DOPEY2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3R5ProtoNet protein and cluster: Q9Y3R5 UniProtKB/Swiss-Prot: DOP2_HUMAN, Q9Y3R5Similarity: Belongs to the dopey family |
Function
for DOPEY2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DOP2_HUMAN, Q9Y3R5Function: May be involved in protein traffic between late Golgi and early endosomes (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOPEY2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOPEY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DOPEY2 (NM_005128) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOPEY2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOPEY2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOPEY2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
DOPEY2 for ontologies About GeneDecksing
|
Pathways & Interactions
for DOPEY2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOPEY2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for DOPEY2 (ENSP000003821044) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
DOPEY2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DOPEY2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DOPEY2
Search CenterWatch for drugs/clinical trials and news about DOPEY2 / DOP2
|
Transcripts
for DOPEY2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DOPEY2 gene: NM_005128.2 Unigene Cluster for DOPEY2: Dopey family member 2 Hs.204575 [show with all ESTs]Unigene Representative Sequence: NM_0051288 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000270190 ENST00000399151(uc002yvh.3 uc002yvg.3 uc011aeb.2)
ENST00000492760 ENST00000463668 ENST00000414001 ENST00000445834 ENST00000435949
ENST00000418642
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOPEY2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOPEY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DOPEY2 (NM_005128) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOPEY2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOPEY2 |
Additional cDNA sequence: AB023150.2 AJ001857.1 AJ237839.2 AK025095.1 AK026478.1 BC012791.2 6 DOTS entries: DT.40285384 DT.100747276 DT.101980259 DT.121139296 DT.40223446 DT.91889911 24/75 AceView cDNA sequences (see all 75): AI510780 BQ927561 AK025095 BU152648 CR613258 AA931930 AL546074 BX643639 BX091550 BE465311 NM_005128 AB023150 AA987490 BC012791 BM762343 AJ237839 AW083855 BX483490 BP364624 AW085802 BE551040 AW575790 BX389506 AL571566
GeneLoc Exon Structure
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Expression
for DOPEY2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DOPEY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DOPEY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOPEY2
SOURCE GeneReport for Unigene cluster: Hs.204575
UniProtKB/Swiss-Prot: DOP2_HUMAN, Q9Y3R5Tissue specificity: Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients
SABiosciences Custom PCR Arrays for DOPEY2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOPEY2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOPEY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOPEY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOPEY2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOPEY2 |
Orthologs
for DOPEY2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DOPEY2 gene from 5/21 species (see all 21) About this table
ENSEMBL Gene Tree for DOPEY2 (if available)
TreeFam Gene Tree for DOPEY2 (if available) |
Paralogs
for DOPEY2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DOPEY2 gene
- DOPEY12
1 SIMAP similar gene for DOPEY2 using alignment to 2 protein entries: DOP2_HUMAN (see all proteins):DOPEY1
DOPEY2 for paralogs About GeneDecksing
|
Genomic Variants
for DOPEY2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DOPEY2 (37529080 - 37711195 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for DOPEY2
7 CNVs: 39303 8894 8893 103085 50772 34484 7322 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOPEY2 |
|
Disorders
/ Diseases
for DOPEY2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DOPEY2 for disorders About GeneDecksing
OMIM gene information: 604803
OMIM disorders: --
2  diseases for DOPEY2: About MalaCardsintellectual disability down syndrome
1 disease from the University of Copenhagen DISEASES database for DOPEY2:Down syndrome Human Genome Epidemiology (HuGE) Navigator: DOPEY2 (1 document)
Export disorders for DOPEY2 gene to outside databases
|
Publications
for DOPEY2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DOPEY2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DOPEY2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. (PubMed id 10931277)1, 2, 3 Pascon R.C. and Miller B.L. (2000)
- Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PubMed id 16301316)1, 3 Gillingham A.K.... Munro S. (2006)
- C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down syndrome. (PubMed id 16276086)1, 2 Rachidi M.... Delabar J.-M. (2006)
- C21orf5, a new member of Dopey family involved in mor phogenesis, could participate in neurological alterations and mental retardatio n in Down syndrome. (PubMed id 16303751)1, 3 Rachidi M....Delabar J.M. (2005)
- The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. (PubMed id 12767918)1, 2 Lopes C.... Rachidi M. (2003)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning. (PubMed id 10950924)1, 2 Guipponi M.... Antonarakis S.E. (2000)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
- Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
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External Searches for DOPEY2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DOPEY2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DOPEY2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DOPEY2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DOPEY2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DOPEY2 gene:
Search GeneIP for patents involving DOPEY2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DOPEY2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DOPEY2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOPEY2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOPEY2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DOPEY2 | | OriGene 3'-UTR Clone for DOPEY2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOPEY2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOPEY2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DOPEY2 | | OriGene Custom Protein Services for DOPEY2 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOPEY2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOPEY2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOPEY2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOPEY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOPEY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOPEY2 |
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| | | | Search Tocris compounds for DOPEY2 |
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 | | | DOPEY2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOPEY2 |
|  |  |  | | | | Search ThermoFisher Antibodies for DOPEY2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOPEY2 |
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