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Aliases for DOPEY2 Gene

Aliases for DOPEY2 Gene

  • Dopey Family Member 2 2 3
  • KIAA0933 4 6
  • C21orf5 3 4
  • 21orf5 3 6
  • Chromosome 21 Open Reading Frame 5 2
  • Homolog Of Yeast DOP1 3
  • Protein Dopey-2 3

External Ids for DOPEY2 Gene

Previous HGNC Symbols for DOPEY2 Gene

  • C21orf5

Previous GeneCards Identifiers for DOPEY2 Gene

  • GC21P036459
  • GC21P037529
  • GC21P023014

Summaries for DOPEY2 Gene

GeneCards Summary for DOPEY2 Gene

DOPEY2 (Dopey Family Member 2) is a Protein Coding gene. An important paralog of this gene is DOPEY1.

UniProtKB/Swiss-Prot for DOPEY2 Gene

  • May be involved in protein traffic between late Golgi and early endosomes.

Gene Wiki entry for DOPEY2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOPEY2 Gene

Genomics for DOPEY2 Gene

Regulatory Elements for DOPEY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOPEY2 Gene

Start:
36,156,782 bp from pter
End:
36,294,274 bp from pter
Size:
137,493 bases
Orientation:
Plus strand

Genomic View for DOPEY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOPEY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOPEY2 Gene

Proteins for DOPEY2 Gene

  • Protein details for DOPEY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3R5-DOP2_HUMAN
    Recommended name:
    Protein dopey-2
    Protein Accession:
    Q9Y3R5
    Secondary Accessions:
    • D3DSG5
    • Q6PJQ7
    • Q9UEZ3

    Protein attributes for DOPEY2 Gene

    Size:
    2298 amino acids
    Molecular mass:
    258230 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DOPEY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOPEY2 Gene

Proteomics data for DOPEY2 Gene at MOPED

Post-translational modifications for DOPEY2 Gene

  • Ubiquitination at Lys23 and Lys420
  • Modification sites at PhosphoSitePlus

Other Protein References for DOPEY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DOPEY2 Gene

Domains for DOPEY2 Gene

Protein Domains for DOPEY2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DOPEY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3R5

UniProtKB/Swiss-Prot:

DOP2_HUMAN :
  • Q9Y3R5
Family:
  • Belongs to the dopey family.
genes like me logo Genes that share domains with DOPEY2: view

No data available for Gene Families for DOPEY2 Gene

Function for DOPEY2 Gene

Molecular function for DOPEY2 Gene

UniProtKB/Swiss-Prot Function: May be involved in protein traffic between late Golgi and early endosomes.

Gene Ontology (GO) - Molecular Function for DOPEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DOPEY2: view

Phenotypes for DOPEY2 Gene

genes like me logo Genes that share phenotypes with DOPEY2: view

Animal Model Products

CRISPR Products

miRNA for DOPEY2 Gene

miRTarBase miRNAs that target DOPEY2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DOPEY2 Gene

Localization for DOPEY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOPEY2 Gene COMPARTMENTS Subcellular localization image for DOPEY2 gene
Compartment Confidence
golgi apparatus 3
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DOPEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS 16301316
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DOPEY2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOPEY2 Gene

Pathways for DOPEY2 Gene

SuperPathways for DOPEY2 Gene

No Data Available

Interacting Proteins for DOPEY2 Gene

Gene Ontology (GO) - Biological Process for DOPEY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport ISS 16301316
GO:0007029 endoplasmic reticulum organization ISS 16301316
GO:0007275 multicellular organismal development NAS 10950924
GO:0015031 protein transport IEA --
GO:0050890 cognition IMP 23227193
genes like me logo Genes that share ontologies with DOPEY2: view

No data available for Pathways by source for DOPEY2 Gene

Transcripts for DOPEY2 Gene

Unigene Clusters for DOPEY2 Gene

Dopey family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOPEY2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DOPEY2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOPEY2 Gene

No ASD Table

Relevant External Links for DOPEY2 Gene

GeneLoc Exon Structure for
DOPEY2
ECgene alternative splicing isoforms for
DOPEY2

Expression for DOPEY2 Gene

mRNA expression in normal human tissues for DOPEY2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOPEY2 Gene

SOURCE GeneReport for Unigene cluster for DOPEY2 Gene Hs.204575

mRNA Expression by UniProt/SwissProt for DOPEY2 Gene

Q9Y3R5-DOP2_HUMAN
Tissue specificity: Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients.
genes like me logo Genes that share expressions with DOPEY2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DOPEY2 Gene

Orthologs for DOPEY2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOPEY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOPEY2 35
  • 99.48 (n)
  • 99.74 (a)
DOPEY2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DOPEY2 35
  • 83.44 (n)
  • 86.31 (a)
DOPEY2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOPEY2 35
  • 87.41 (n)
  • 90.07 (a)
DOPEY2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dopey2 35
  • 83.1 (n)
  • 86.57 (a)
Dopey2 16
Dopey2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOPEY2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOPEY2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dopey2 35
  • 83.24 (n)
  • 86.44 (a)
chicken
(Gallus gallus)
Aves DOPEY2 35
  • 71.57 (n)
  • 76.33 (a)
gga-mir-7452 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOPEY2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dopey2 35
  • 68.14 (n)
  • 70.83 (a)
zebrafish
(Danio rerio)
Actinopterygii dopey2 36
  • 56 (a)
OneToOne
zgc63622 35
fruit fly
(Drosophila melanogaster)
Insecta CG15099 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pad-1 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOP1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for DOPEY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOPEY2 Gene

ENSEMBL:
Gene Tree for DOPEY2 (if available)
TreeFam:
Gene Tree for DOPEY2 (if available)

Paralogs for DOPEY2 Gene

Paralogs for DOPEY2 Gene

Selected SIMAP similar genes for DOPEY2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DOPEY2: view

Variants for DOPEY2 Gene

Sequence variations from dbSNP and Humsavar for DOPEY2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs4174 -- 36,261,525(-) GGGGA(A/G)AAACC intron-variant
rs885808 -- 36,182,043(+) CTTAT(A/G)TATTA intron-variant
rs885875 -- 36,182,645(+) GCAAC(A/G)TAGCC intron-variant
rs1012931 -- 36,207,152(+) CTGTT(A/C/G)TTCTG intron-variant
rs1023367 -- 36,247,426(+) CTCTC(C/T)CTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOPEY2 Gene

Variant ID Type Subtype PubMed ID
esv2751927 CNV Gain 17911159
esv2751928 CNV Gain 17911159
esv33578 CNV Loss 17666407
nsv459249 CNV Gain 19166990
nsv516175 CNV Gain 19592680
esv2456821 CNV Deletion 19546169
nsv510797 CNV Loss 20534489
nsv913734 CNV Gain 21882294
esv2723391 CNV Deletion 23290073
esv2670565 CNV Deletion 23128226

Relevant External Links for DOPEY2 Gene

HapMap Linkage Disequilibrium report
DOPEY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOPEY2 Gene

Disorders for DOPEY2 Gene

(1) University of Copenhagen DISEASES for DOPEY2 Gene

Relevant External Links for DOPEY2

Genetic Association Database (GAD)
DOPEY2
Human Genome Epidemiology (HuGE) Navigator
DOPEY2
genes like me logo Genes that share disorders with DOPEY2: view

No data available for UniProtKB/Swiss-Prot for DOPEY2 Gene

Publications for DOPEY2 Gene

  1. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. (PMID: 10931277) Pascon R.C. … Miller B.L. (Mol. Microbiol. 2000) 2 3 4
  2. C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning. (PMID: 10950924) Guipponi M. … Antonarakis S.E. (Genomics 2000) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. The differentially expressed C21orf5 gene in the medial temporal-lobe system could play a role in mental retardation in Down syndrome and transgenic mice. (PMID: 12767918) Lopes C. … Rachidi M. (Biochem. Biophys. Res. Commun. 2003) 3 4
  5. C21orf5, a human candidate gene for brain abnormalities and mental retardation in Down syndrome. (PMID: 16276086) Rachidi M. … Delabar J.-M. (Cytogenet. Genome Res. 2006) 3 4

Products for DOPEY2 Gene

Sources for DOPEY2 Gene

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