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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOPEY1 Gene

protein-coding   GIFtS: 43
GCID: GC06P083835

dopey family member 1

(Previous name: KIAA1117 )
(Previous symbol: KIAA1117)
 Explore 1 disease affiliated with
DOPEY1 via our new
 Human Malady Compendium 
Biological research products
for DOPEY1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Dopey Family Member 11 2
KIAA11171 2 3
DJ202D23.21
Homolog Of Yeast DOP12
Protein Dopey-12

External Ids:    HGNC: 211941   Entrez Gene: 230332   Ensembl: ENSG000000830977   UniProtKB: Q5JWR53   

Export aliases for DOPEY1 gene to outside databases

Previous GC identifer: GC06P081005


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DOP1_HUMAN, Q5JWR5
Function: May be involved in protein traffic between late Golgi and early endosomes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOPEY1 gene promoter:
         Max1   S8   GATA-6   COUP   Meis-1a   FOXL1   Meis-1   Meis-1b   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOPEY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOPEY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOPEY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q15

DOPEY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOPEY1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P083835:  view genomic region     (about GC identifiers)

Start:
83,777,385 bp from pter      End:
83,881,069 bp from pter
Size:
103,685 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOP1_HUMAN, Q5JWR5 (See protein sequence)
Recommended Name: Protein dopey-1  
Size: 2465 amino acids; 277355 Da
Sequence caution: Sequence=BAB15631.1; Type=Erroneous initiation;
Secondary accessions: Q86XV1 Q9H5J5 Q9NSL4 Q9UPN5 Q9Y414

Explore the universe of human proteins at neXtProt for DOPEY1: NX_Q5JWR5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5JWR5

  • DOPEY1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186871.1  NP_055833.2  

    ENSEMBL proteins: 
     ENSP00000195654   ENSP00000358754   ENSP00000237163   ENSP00000439675  

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    Uscn Proteins for DOPEY1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----


    DOPEY1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DOPEY1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DOPEY1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007249 Dopey_N

    Graphical View of Domain Structure for InterPro Entry Q5JWR5

    ProtoNet protein and cluster: Q5JWR5

    UniProtKB/Swiss-Prot: DOP1_HUMAN, Q5JWR5
    Similarity: Belongs to the dopey family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DOP1_HUMAN, Q5JWR5
    Function: May be involved in protein traffic between late Golgi and early endosomes (By similarity)

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOPEY1

    2 Interacting proteins for DOPEY1 (Q5JWR53) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSNP260383I2D: score=2 
    RBL1P287493I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006895Golgi to endosome transport ----
    GO:0007029endoplasmic reticulum organization ----
    GO:0015031protein transport IEA--


    DOPEY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOPEY1
    Search CenterWatch for drugs/clinical trials and news about DOPEY1 / DOP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOPEY1 gene (2 alternative transcripts): 
    NM_001199942.1  NM_015018.3  

    Unigene Clusters for DOPEY1:

    Dopey family member 1
    Hs.520246  [show with all ESTs], Hs.708998
    Unigene Representative Sequences: NM_001199942, BC036257
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349129(uc011dyy.2 uc003pjs.1 uc010kbl.1) ENST00000369739
    ENST00000493541 ENST00000484282(uc003pjt.3) ENST00000481979 ENST00000237163
    ENST00000536812

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DOPEY1:
    hsa-miR-593* hsa-miR-767-5p
    SwitchGear 3'UTR luciferase reporter plasmidDOPEY1 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: DOPEY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOPEY1
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOPEY1
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    Additional cDNA sequence: BC036257.1 

    9 DOTS entries:

    DT.95178650  DT.97778253  DT.214469  DT.99933312  DT.91755649  DT.121328688  DT.75196420  DT.91755653 
    DT.100804173 

    24/109 AceView cDNA sequences (see all 109):

    AA911485 AK027030 BP378340 AB029040 AA386034 AL050080 AI222079 AA625526 
    BC048342 Z42610 AL162056 NM_015018 CA393739 BX415490 CD676565 Z44640 
    AI453281 F05975 CD244222 AK094766 AA902258 F02219 AL704073 F03679 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DOPEY1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                    -                                                           -                           
    SP2:        -                                                                                                                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40
    SP1:        -                                                                 -                             -               
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for DOPEY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOPEY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAAGTCCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DOPEY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOPEY1

    SOURCE GeneReport for Unigene clusters: Hs.520246 Hs.708998
        SABiosciences Custom PCR Arrays for DOPEY1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DOPEY1 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dopey11 , 5 dopey family member 11, 5 89.36(n)1
    93.42(a)1
      9 (46.58 cM)5
    3206151  NM_177208.31  NP_796182.21 
     864854075 
    chicken
    (Gallus gallus)
    Aves DOPEY11 dopey family member 1 80.12(n)
    88.36(a)
      421842  XM_419863.3  XP_419863.3 
    lizard
    (Anolis carolinensis)
    Reptilia DOPEY16
    --
    86(a)
    1 ↔ 1
    1(197766116-197822786)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.188562 Transcribed sequence with weak similarity to protein refNP_005119.1 (H.sapiens) chromosome 21 open reading frame 5 [Homo sapiens] less 79.39(n)    AL896134.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.187902 Transcribed sequence with moderate similarity to protein pirT47141 (H.sapiens) T47141 hypothetical protein DKFZp761N1024.1 - human (fragment) less 76.35(n)    BQ618339.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG150991 CG15099 44.17(n)
    36.34(a)
      37176  NM_137537.3  NP_611381.2 
    worm
    (Caenorhabditis elegans)
    Secernentea pad-11 Protein PAD-1 45.4(n)
    34.16(a)
      173156  NM_060851.3  NP_493252.3 


    ENSEMBL Gene Tree for DOPEY1 (if available)
    TreeFam Gene Tree for DOPEY1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOPEY1 gene
    DOPEY22  
    1 SIMAP similar gene for DOPEY1 using alignment to 6 protein entries:     DOP1_HUMAN (see all proteins):
    DOPEY2

    DOPEY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1558 NCBI SNPs in DOPEY1 are shown (see all 1558    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785516161,2
    C,--83775482(+) CCGAGG/AGGCCC 3 -- ut51 us2k12Minor allele frequency- A:0.10CSA WA 120
    rs1495603391,2
    --83775569(+) AGATCG/TCAGGG 3 -- us2k10--------
    rs1918093481,2
    --83775612(+) GCCGGC/TCGGAG 3 -- us2k10--------
    rs787599711,2
    F,--83775771(+) GTTAGC/TATCCC 3 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1442586211,2
    --83775805(+) CCCAGC/GGTTCA 3 -- us2k10--------
    rs1831476531,2
    --83775960(+) TCTATC/TTAAAG 3 -- us2k10--------
    rs785494961,2
    C,--83776077(+) GCAGAA/GGAGTG 3 -- us2k12Minor allele frequency- G:0.02NA 122
    rs1484768431,2
    --83776123(+) GGGTAA/GAAAAG 3 -- us2k10--------
    rs729038391,2
    C,F,--83776144(+) ATGATT/GACGTA 3 -- us2k11Minor allele frequency- G:0.04NA 120
    rs1881883231,2
    --83776358(+) TATTTA/TTTTTC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DOPEY1 (83777385 - 83881069 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DOPEY1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOPEY1
    DNA2.0 Custom Variant and Variant Library Synthesis for DOPEY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DOPEY1 for disorders           About GeneDecksing

    1 disease for DOPEY1:    About MalaCards
    down syndrome


    Export disorders for DOPEY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOPEY1 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DOPEY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PubMed id 16301316)1, 3 Gillingham A.K.... Munro S. (2006)
    2. C21orf5, a new member of Dopey family involved in mor phogenesis, could participate in neurological alterations and mental retardatio n in Down syndrome. (PubMed id 16303751)1, 3 Rachidi M....Delabar J.M. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. (PubMed id 10931277)1, 3 Pascon R.C. and Miller B.L. (2000)
    5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23033 HGNC: 21194 AceView: KIAA1117 Ensembl:ENSG00000083097 euGenes: HUgn23033
    ECgene: DOPEY1 H-InvDB: DOPEY1

    (According to HUGE)
    About This Section
    HUGE: KIAA1117

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOPEY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOPEY1 gene:
    Search GeneIP for patents involving DOPEY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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