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Aliases for DOPEY1 Gene

Aliases for DOPEY1 Gene

  • Dopey Family Member 1 2 3 5
  • KIAA1117 2 3 4
  • Homolog Of Yeast DOP1 3
  • Protein Dopey-1 3
  • DJ202D23.2 3
  • DOP1 3

External Ids for DOPEY1 Gene

Previous HGNC Symbols for DOPEY1 Gene

  • KIAA1117

Previous GeneCards Identifiers for DOPEY1 Gene

  • GC06P083835
  • GC06P081005

Summaries for DOPEY1 Gene

GeneCards Summary for DOPEY1 Gene

DOPEY1 (Dopey Family Member 1) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is DOPEY2.

UniProtKB/Swiss-Prot for DOPEY1 Gene

  • May be involved in protein traffic between late Golgi and early endosomes.

Additional gene information for DOPEY1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOPEY1 Gene

Genomics for DOPEY1 Gene

Regulatory Elements for DOPEY1 Gene

Enhancers for DOPEY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H083866 1.7 FANTOM5 Ensembl ENCODE 69.4 +800.3 800263 2 PKNOX1 FEZF1 ZNF2 CBX5 ZNF302 ZNF416 ZNF143 FOS ZNF548 CEBPZ CEP162 DOPEY1 UBE3D RWDD2A RIPPLY2 CYB5R4 PIR41363 GC06P083900
GH06H083067 1.3 Ensembl ENCODE 37 +2.3 2273 5 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 DEK SP3 DOPEY1 SNAP91 RWDD2A
GH06H082396 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.3 -669.5 -669533 3 TBP INSM2 FEZF1 ZNF2 ZBTB40 ZNF366 FOS ZNF391 RUNX3 SP3 DOPEY1 TPBG UBE3D GC06M082379 GC06M082439
GH06H082259 1 ENCODE 31.5 -806.0 -805962 3 PKNOX1 ARNT FEZF1 ZNF2 ZNF121 GLIS2 ZNF302 KLF7 FOS SP3 DOPEY1 UBE3D LOC100132659 IBTK TPBG PGM3 GC06P082262
GH06H082143 1.5 FANTOM5 Ensembl ENCODE 15.1 -923.1 -923121 2 FOXA2 FEZF1 ZNF2 FOS DEK TSHZ1 ZNF518A STAT3 WT1 SP7 DOPEY1 LINC02542 RNU6-130P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOPEY1 on UCSC Golden Path with GeneCards custom track

Promoters for DOPEY1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199476 440 1401 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 DEK SP3

Genomic Location for DOPEY1 Gene

Chromosome:
6
Start:
83,067,660 bp from pter
End:
83,171,350 bp from pter
Size:
103,691 bases
Orientation:
Plus strand

Genomic View for DOPEY1 Gene

Genes around DOPEY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOPEY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOPEY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOPEY1 Gene

Proteins for DOPEY1 Gene

  • Protein details for DOPEY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JWR5-DOP1_HUMAN
    Recommended name:
    Protein dopey-1
    Protein Accession:
    Q5JWR5
    Secondary Accessions:
    • Q86XV1
    • Q9H5J5
    • Q9NSL4
    • Q9UPN5
    • Q9Y414

    Protein attributes for DOPEY1 Gene

    Size:
    2465 amino acids
    Molecular mass:
    277355 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15631.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DOPEY1 Gene

Post-translational modifications for DOPEY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOPEY1 Gene

Domains & Families for DOPEY1 Gene

Gene Families for DOPEY1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DOPEY1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JWR5

UniProtKB/Swiss-Prot:

DOP1_HUMAN :
  • Belongs to the dopey family.
Family:
  • Belongs to the dopey family.
genes like me logo Genes that share domains with DOPEY1: view

Function for DOPEY1 Gene

Molecular function for DOPEY1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein traffic between late Golgi and early endosomes.

Phenotypes From GWAS Catalog for DOPEY1 Gene

genes like me logo Genes that share phenotypes with DOPEY1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOPEY1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DOPEY1 Gene

Localization for DOPEY1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOPEY1 gene
Compartment Confidence
golgi apparatus 4
endosome 4
plasma membrane 3
cytosol 3
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DOPEY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005802 trans-Golgi network IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with DOPEY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOPEY1 Gene

Pathways & Interactions for DOPEY1 Gene

SuperPathways for DOPEY1 Gene

No Data Available

Interacting Proteins for DOPEY1 Gene

Gene Ontology (GO) - Biological Process for DOPEY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006895 Golgi to endosome transport IBA,ISS --
GO:0007029 endoplasmic reticulum organization ISS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with DOPEY1: view

No data available for Pathways by source and SIGNOR curated interactions for DOPEY1 Gene

Drugs & Compounds for DOPEY1 Gene

No Compound Related Data Available

Transcripts for DOPEY1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOPEY1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DOPEY1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for DOPEY1 Gene

GeneLoc Exon Structure for
DOPEY1
ECgene alternative splicing isoforms for
DOPEY1

Expression for DOPEY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOPEY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOPEY1 Gene

This gene is overexpressed in Liver (33.0) and Urine (30.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOPEY1 Gene



Protein tissue co-expression partners for DOPEY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DOPEY1 Gene:

DOPEY1

SOURCE GeneReport for Unigene cluster for DOPEY1 Gene:

Hs.520246

Evidence on tissue expression from TISSUES for DOPEY1 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with DOPEY1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOPEY1 Gene

Orthologs for DOPEY1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOPEY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOPEY1 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia DOPEY1 33 34
  • 93.21 (n)
cow
(Bos Taurus)
Mammalia DOPEY1 33 34
  • 91.87 (n)
oppossum
(Monodelphis domestica)
Mammalia DOPEY1 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dopey1 33 16 34
  • 89.36 (n)
rat
(Rattus norvegicus)
Mammalia Dopey1 33
  • 89.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DOPEY1 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOPEY1 33 34
  • 80.16 (n)
lizard
(Anolis carolinensis)
Reptilia DOPEY1 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dopey1 33
  • 78.4 (n)
Str.18856 33
zebrafish
(Danio rerio)
Actinopterygii dopey1 33 34
  • 67.49 (n)
Dr.18790 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4902 33
fruit fly
(Drosophila melanogaster)
Insecta CG15099 33 34
  • 48.31 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007605 33
  • 48.14 (n)
worm
(Caenorhabditis elegans)
Secernentea pad-1 34
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOP1 34 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
Species where no ortholog for DOPEY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOPEY1 Gene

ENSEMBL:
Gene Tree for DOPEY1 (if available)
TreeFam:
Gene Tree for DOPEY1 (if available)

Paralogs for DOPEY1 Gene

Paralogs for DOPEY1 Gene

(1) SIMAP similar genes for DOPEY1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with DOPEY1: view

Variants for DOPEY1 Gene

Sequence variations from dbSNP and Humsavar for DOPEY1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036607 A breast cancer sample
rs267608261 Pathogenic 83,170,340(-) CAGAA(G/T)ATGTC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs587777413 Pathogenic 83,170,343(+) ATCTT(C/G)TGTAC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs143654268 Uncertain significance 83,169,251(+) TTGGG(G/T)CCTTT intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1000017406 -- 83,097,860(+) ATTTT(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOPEY1 Gene

Variant ID Type Subtype PubMed ID
esv3407297 CNV insertion 20981092
esv3609773 CNV loss 21293372
nsv1026095 CNV gain 25217958

Variation tolerance for DOPEY1 Gene

Residual Variation Intolerance Score: 1.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOPEY1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOPEY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOPEY1 Gene

Disorders for DOPEY1 Gene

Relevant External Links for DOPEY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOPEY1

No disorders were found for DOPEY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOPEY1 Gene

Publications for DOPEY1 Gene

  1. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham AK … Munro S (The Journal of biological chemistry 2006) 2 3 60
  2. C21orf5, a new member of Dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in Down syndrome. (PMID: 16303751) Rachidi M … Delabar JM (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. (PMID: 10931277) Pascon RC … Miller BL (Molecular microbiology 2000) 2 3 60
  5. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 60

Products for DOPEY1 Gene

Sources for DOPEY1 Gene

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