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Aliases for DOPEY1 Gene

Aliases for DOPEY1 Gene

  • Dopey Family Member 1 2 3
  • KIAA1117 2 3 4
  • Homolog Of Yeast DOP1 3
  • Protein Dopey-1 3
  • DJ202D23.2 3

External Ids for DOPEY1 Gene

Previous HGNC Symbols for DOPEY1 Gene

  • KIAA1117

Previous GeneCards Identifiers for DOPEY1 Gene

  • GC06P083835
  • GC06P081005

Summaries for DOPEY1 Gene

GeneCards Summary for DOPEY1 Gene

DOPEY1 (Dopey Family Member 1) is a Protein Coding gene. An important paralog of this gene is DOPEY2.

UniProtKB/Swiss-Prot for DOPEY1 Gene

  • May be involved in protein traffic between late Golgi and early endosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOPEY1 Gene

Genomics for DOPEY1 Gene

Regulatory Elements for DOPEY1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOPEY1 Gene

83,067,666 bp from pter
83,171,350 bp from pter
103,685 bases
Plus strand

Genomic View for DOPEY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOPEY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOPEY1 Gene

Proteins for DOPEY1 Gene

  • Protein details for DOPEY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein dopey-1
    Protein Accession:
    Secondary Accessions:
    • Q86XV1
    • Q9H5J5
    • Q9NSL4
    • Q9UPN5
    • Q9Y414

    Protein attributes for DOPEY1 Gene

    2465 amino acids
    Molecular mass:
    277355 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15631.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DOPEY1 Gene

Proteomics data for DOPEY1 Gene at MOPED

Post-translational modifications for DOPEY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOPEY1 Gene

No data available for DME Specific Peptides for DOPEY1 Gene

Domains for DOPEY1 Gene

Protein Domains for DOPEY1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q5JWR5
  • Belongs to the dopey family.
genes like me logo Genes that share domains with DOPEY1: view

No data available for Gene Families for DOPEY1 Gene

Function for DOPEY1 Gene

Molecular function for DOPEY1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protein traffic between late Golgi and early endosomes.

Gene Ontology (GO) - Molecular Function for DOPEY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with DOPEY1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DOPEY1 Gene

Localization for DOPEY1 Gene

Subcellular locations from

Jensen Localization Image for DOPEY1 Gene COMPARTMENTS Subcellular localization image for DOPEY1 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DOPEY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane --
genes like me logo Genes that share ontologies with DOPEY1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOPEY1 Gene

Pathways for DOPEY1 Gene

SuperPathways for DOPEY1 Gene

No Data Available

Interacting Proteins for DOPEY1 Gene

Gene Ontology (GO) - Biological Process for DOPEY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006895 Golgi to endosome transport --
GO:0007029 endoplasmic reticulum organization --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with DOPEY1: view

No data available for Pathways by source for DOPEY1 Gene

Transcripts for DOPEY1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOPEY1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOPEY1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40
SP1: - - -

Relevant External Links for DOPEY1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOPEY1 Gene

mRNA expression in normal human tissues for DOPEY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DOPEY1 Gene

This gene is overexpressed in Liver (33.0) and Urine (30.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOPEY1 Gene

SOURCE GeneReport for Unigene cluster for DOPEY1 Gene Hs.520246

genes like me logo Genes that share expressions with DOPEY1: view

Expression partners for DOPEY1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DOPEY1 Gene

Orthologs for DOPEY1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOPEY1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DOPEY1 35
  • 91.87 (n)
  • 95.33 (a)
  • 95 (a)
(Canis familiaris)
Mammalia DOPEY1 35
  • 93.21 (n)
  • 96.19 (a)
  • 96 (a)
(Mus musculus)
Mammalia Dopey1 35
  • 89.36 (n)
  • 93.42 (a)
Dopey1 16
Dopey1 36
  • 93 (a)
(Pan troglodytes)
Mammalia DOPEY1 35
  • 99.43 (n)
  • 99.31 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Dopey1 35
  • 89.19 (n)
  • 93.31 (a)
(Monodelphis domestica)
Mammalia DOPEY1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia DOPEY1 36
  • 87 (a)
(Gallus gallus)
Aves DOPEY1 35
  • 80.16 (n)
  • 88.4 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia DOPEY1 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dopey1 35
  • 78.4 (n)
  • 87.8 (a)
Str.18856 35
(Danio rerio)
Actinopterygii dopey1 35
  • 67.49 (n)
  • 73.53 (a)
Dr.18790 35
dopey1 36
  • 70 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4902 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007605 35
  • 48.14 (n)
  • 41.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15099 35
  • 48.31 (n)
  • 41.89 (a)
CG15099 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea pad-1 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DOP1 36
  • 20 (a)
DOP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
-- 36
  • 29 (a)
Species with no ortholog for DOPEY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOPEY1 Gene

Gene Tree for DOPEY1 (if available)
Gene Tree for DOPEY1 (if available)

Paralogs for DOPEY1 Gene

Paralogs for DOPEY1 Gene

Selected SIMAP similar genes for DOPEY1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with DOPEY1: view

Variants for DOPEY1 Gene

Sequence variations from dbSNP and Humsavar for DOPEY1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs481325 -- 83,163,352(-) TACTG(C/T)ATTTT intron-variant
rs482899 -- 83,149,475(-) TACTT(C/T)GCCCC intron-variant
rs490022 -- 83,132,386(-) AGTAT(G/T)TGTGT intron-variant
rs491330 -- 83,142,472(-) GGAGT(A/G)CAGTG intron-variant
rs491454 -- 83,142,422(-) CAAGC(A/G)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOPEY1 Gene

Variant ID Type Subtype PubMed ID
nsv886329 CNV Loss 21882294

Relevant External Links for DOPEY1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOPEY1 Gene

Disorders for DOPEY1 Gene

No disorders were found for DOPEY1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DOPEY1 Gene

Publications for DOPEY1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus. (PMID: 16301316) Gillingham A.K. … Munro S. (J. Biol. Chem. 2006) 2 3
  3. C21orf5, a new member of Dopey family involved in morphogenesis, could participate in neurological alterations and mental retardation in Down syndrome. (PMID: 16303751) Rachidi M. … Delabar J.M. (DNA Res. 2005) 2 3
  4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  5. Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans. (PMID: 10931277) Pascon R.C. … Miller B.L. (Mol. Microbiol. 2000) 2 3

Products for DOPEY1 Gene

Sources for DOPEY1 Gene

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