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Aliases for DONSON Gene

Aliases for DONSON Gene

  • Downstream Neighbor Of SON 2 3
  • C21orf60 3 4
  • B17 3 4

External Ids for DONSON Gene

Previous HGNC Symbols for DONSON Gene

  • C21orf60

Previous GeneCards Identifiers for DONSON Gene

  • GC21U990030
  • GC21M031608
  • GC21M033870
  • GC21M033873
  • GC21M034948
  • GC21M020428

Summaries for DONSON Gene

Entrez Gene Summary for DONSON Gene

  • This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for DONSON Gene

DONSON (Downstream Neighbor Of SON) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DONSON Gene

  • Essential for DNA amplification in the ovary and required for cell proliferation during development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DONSON Gene

Genomics for DONSON Gene

Regulatory Elements for DONSON Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DONSON Gene

Chromosome:
21
Start:
33,559,542 bp from pter
End:
33,588,708 bp from pter
Size:
29,167 bases
Orientation:
Minus strand

Genomic View for DONSON Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DONSON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DONSON Gene

Proteins for DONSON Gene

  • Protein details for DONSON Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYP3-DONS_HUMAN
    Recommended name:
    Protein downstream neighbor of Son
    Protein Accession:
    Q9NYP3
    Secondary Accessions:
    • Q8NC53
    • Q9NSR9
    • Q9NVZ5
    • Q9NYP1
    • Q9NYP2

    Protein attributes for DONSON Gene

    Size:
    566 amino acids
    Molecular mass:
    62747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DONSON Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DONSON Gene

Proteomics data for DONSON Gene at MOPED

Post-translational modifications for DONSON Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DONSON Gene

Domains & Families for DONSON Gene

Protein Domains for DONSON Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DONSON Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYP3

UniProtKB/Swiss-Prot:

DONS_HUMAN :
  • Belongs to the DONSON family.
Family:
  • Belongs to the DONSON family.
genes like me logo Genes that share domains with DONSON: view

No data available for Gene Families for DONSON Gene

Function for DONSON Gene

Molecular function for DONSON Gene

UniProtKB/Swiss-Prot Function:
Essential for DNA amplification in the ovary and required for cell proliferation during development.

Gene Ontology (GO) - Molecular Function for DONSON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DONSON: view
genes like me logo Genes that share phenotypes with DONSON: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DONSON

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DONSON Gene

Localization for DONSON Gene

Subcellular locations from UniProtKB/Swiss-Prot for DONSON Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DONSON Gene COMPARTMENTS Subcellular localization image for DONSON gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DONSON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DONSON: view

Pathways & Interactions for DONSON Gene

SuperPathways for DONSON Gene

No Data Available

Interacting Proteins for DONSON Gene

Gene Ontology (GO) - Biological Process for DONSON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DONSON: view

No data available for Pathways by source and SIGNOR curated interactions for DONSON Gene

Drugs & Compounds for DONSON Gene

No Compound Related Data Available

Transcripts for DONSON Gene

Unigene Clusters for DONSON Gene

Downstream neighbor of SON:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DONSON

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DONSON Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b · 14c ·
SP1: - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: -
SP8: - - - - -
SP9:
SP10:
SP11: - - - - - - -
SP12: - - - - - - - -
SP13:
SP14:
SP15: - - -
SP16: - -
SP17:
SP18:

ExUns: 14d ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9: -
SP10: - - - - - -
SP11:
SP12: -
SP13: - - - -
SP14: - -
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DONSON Gene

GeneLoc Exon Structure for
DONSON
ECgene alternative splicing isoforms for
DONSON

Expression for DONSON Gene

mRNA expression in normal human tissues for DONSON Gene

Protein differential expression in normal tissues from HIPED for DONSON Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DONSON Gene



SOURCE GeneReport for Unigene cluster for DONSON Gene Hs.436341

genes like me logo Genes that share expression patterns with DONSON: view

Protein tissue co-expression partners for DONSON Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DONSON Gene

Orthologs for DONSON Gene

This gene was present in the common ancestor of animals.

Orthologs for DONSON Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DONSON 35
  • 87.16 (n)
  • 84.59 (a)
DONSON 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC478407 35
  • 88.6 (n)
  • 86.71 (a)
-- 36
  • 83 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Donson 35
  • 80 (n)
  • 77.68 (a)
Donson 16
Donson 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DONSON 35
  • 99.41 (n)
  • 99.29 (a)
DONSON 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Donson 35
  • 81.34 (n)
  • 79.01 (a)
oppossum
(Monodelphis domestica)
Mammalia DONSON 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DONSON 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DONSON 35
  • 68.23 (n)
  • 67.23 (a)
DONSON 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DONSON 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia donson 35
  • 65.01 (n)
  • 65.01 (a)
MGC76196 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6441 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.503 35
fruit fly
(Drosophila melanogaster)
Insecta CG2669 37
  • 33 (a)
hd 35
  • 46.99 (n)
  • 40.2 (a)
hd 36
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005874 35
  • 48.43 (n)
  • 39.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToOne
Species with no ortholog for DONSON:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DONSON Gene

ENSEMBL:
Gene Tree for DONSON (if available)
TreeFam:
Gene Tree for DONSON (if available)

Paralogs for DONSON Gene

Pseudogenes.org Pseudogenes for DONSON Gene

genes like me logo Genes that share paralogs with DONSON: view

No data available for Paralogs for DONSON Gene

Variants for DONSON Gene

Structural Variations from Database of Genomic Variants (DGV) for DONSON Gene

Variant ID Type Subtype PubMed ID
nsv913724 CNV Loss 21882294
esv2723356 CNV Deletion 23290073

Variation tolerance for DONSON Gene

Residual Variation Intolerance Score: 76.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DONSON Gene

HapMap Linkage Disequilibrium report
DONSON

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DONSON Gene

Disorders for DONSON Gene

Relevant External Links for DONSON

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DONSON
genes like me logo Genes that share disorders with DONSON: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DONSON Gene

Publications for DONSON Gene

  1. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PMID: 10773462) Slavov D. … Gardiner K. (Gene 2000) 2 67
  2. Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. (PMID: 10950926) Wynn S.L. … Buluwela L. (Genomics 2000) 2 67
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 67
  4. Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. (PMID: 22079093) Fedorova O.A. … Barlev N.A. (Biochem. Biophys. Res. Commun. 2011) 67
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 67

Products for DONSON Gene

Sources for DONSON Gene

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