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Aliases for DONSON Gene

Aliases for DONSON Gene

  • Downstream Neighbor Of SON 2 3 5
  • C21orf60 3 4
  • B17 3 4
  • Protein Downstream Neighbor Of Son 3
  • MISSLA 3
  • MIMIS 3

External Ids for DONSON Gene

Previous HGNC Symbols for DONSON Gene

  • C21orf60

Previous GeneCards Identifiers for DONSON Gene

  • GC21U990030
  • GC21M031608
  • GC21M033870
  • GC21M033873
  • GC21M034948
  • GC21M020428

Summaries for DONSON Gene

Entrez Gene Summary for DONSON Gene

  • This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for DONSON Gene

DONSON (Downstream Neighbor Of SON) is a Protein Coding gene. Diseases associated with DONSON include Microcephaly-Micromelia Syndrome and Microcephaly, Short Stature, And Limb Abnormalities.

UniProtKB/Swiss-Prot for DONSON Gene

  • Essential for DNA amplification in the ovary and required for cell proliferation during development.

Additional gene information for DONSON Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DONSON Gene

Genomics for DONSON Gene

Regulatory Elements for DONSON Gene

Enhancers for DONSON Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H034543 2.4 VISTA FANTOM5 Ensembl ENCODE dbSUPER 47.6 -956.8 -956792 3 PKNOX1 FOXA2 ARNT ZNF766 ZNF143 ZNF207 ATF7 RUNX3 JUNB REST DONSON RCAN1 C21orf140 KCNE1 GC21M034521 GC21M034577
GH21H032769 1.2 ENCODE 83.8 +817.4 817355 3 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZC3H11A ZFP41 PAXBP1 TMEM50B SON DONSON C21orf59 EVA1C URB1 MIS18A-AS1 MIS18A GART
GH21H034200 1.4 FANTOM5 ENCODE 40.5 -614.1 -614129 5 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF416 ZNF143 TMEM50B SON DONSON GART SMIM11A C21orf140 MRPS6 ENSG00000214955 GC21P034168
GH21H033539 1.4 ENCODE dbSUPER 38.2 +45.7 45701 6 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 ZNF610 GLIS1 SON PAXBP1 TMEM50B GART DONSON C21orf140 C21orf59 PAXBP1-AS1 DNAJC28 ENSG00000231355
GH21H033201 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.7 +384.7 384747 4 HDGF PKNOX1 SIN3A DMAP1 ZNF48 YY1 FOS ATF7 ZNF548 RUNX3 SON PAXBP1 TMEM50B EVA1C GART DONSON IFNAR2 IFNGR2 URB1 C21orf59
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DONSON on UCSC Golden Path with GeneCards custom track

Promoters for DONSON Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141574 308 2001 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for DONSON Gene

Chromosome:
21
Start:
33,559,542 bp from pter
End:
33,588,708 bp from pter
Size:
29,167 bases
Orientation:
Minus strand

Genomic View for DONSON Gene

Genes around DONSON on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DONSON Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DONSON Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DONSON Gene

Proteins for DONSON Gene

  • Protein details for DONSON Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYP3-DONS_HUMAN
    Recommended name:
    Protein downstream neighbor of Son
    Protein Accession:
    Q9NYP3
    Secondary Accessions:
    • Q8NC53
    • Q9NSR9
    • Q9NVZ5
    • Q9NYP1
    • Q9NYP2

    Protein attributes for DONSON Gene

    Size:
    566 amino acids
    Molecular mass:
    62747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DONSON Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DONSON Gene

Post-translational modifications for DONSON Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DONSON Gene

Domains & Families for DONSON Gene

Gene Families for DONSON Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DONSON Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DONSON Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYP3

UniProtKB/Swiss-Prot:

DONS_HUMAN :
  • Belongs to the DONSON family.
Family:
  • Belongs to the DONSON family.
genes like me logo Genes that share domains with DONSON: view

Function for DONSON Gene

Molecular function for DONSON Gene

UniProtKB/Swiss-Prot Function:
Essential for DNA amplification in the ovary and required for cell proliferation during development.

Phenotypes From GWAS Catalog for DONSON Gene

Gene Ontology (GO) - Molecular Function for DONSON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DONSON: view
genes like me logo Genes that share phenotypes with DONSON: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DONSON
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DONSON Gene

Localization for DONSON Gene

Subcellular locations from UniProtKB/Swiss-Prot for DONSON Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DONSON gene
Compartment Confidence
nucleus 4
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DONSON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with DONSON: view

Pathways & Interactions for DONSON Gene

SuperPathways for DONSON Gene

No Data Available

Interacting Proteins for DONSON Gene

Gene Ontology (GO) - Biological Process for DONSON Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0033260 nuclear DNA replication IBA --
genes like me logo Genes that share ontologies with DONSON: view

No data available for Pathways by source and SIGNOR curated interactions for DONSON Gene

Drugs & Compounds for DONSON Gene

No Compound Related Data Available

Transcripts for DONSON Gene

Unigene Clusters for DONSON Gene

Downstream neighbor of SON:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DONSON
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DONSON Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b · 14c ·
SP1: - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7: -
SP8: - - - - -
SP9:
SP10:
SP11: - - - - - - -
SP12: - - - - - - - -
SP13:
SP14:
SP15: - - -
SP16: - -
SP17:
SP18:

ExUns: 14d ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9: -
SP10: - - - - - -
SP11:
SP12: -
SP13: - - - -
SP14: - -
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DONSON Gene

GeneLoc Exon Structure for
DONSON
ECgene alternative splicing isoforms for
DONSON

Expression for DONSON Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DONSON Gene

Protein differential expression in normal tissues from HIPED for DONSON Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DONSON Gene



Protein tissue co-expression partners for DONSON Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DONSON Gene:

DONSON

SOURCE GeneReport for Unigene cluster for DONSON Gene:

Hs.436341
genes like me logo Genes that share expression patterns with DONSON: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DONSON Gene

Orthologs for DONSON Gene

This gene was present in the common ancestor of animals.

Orthologs for DONSON Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DONSON 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia LOC478407 33
  • 88.6 (n)
-- 34
  • 87 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DONSON 33 34
  • 87.16 (n)
rat
(Rattus norvegicus)
Mammalia Donson 33
  • 81.34 (n)
mouse
(Mus musculus)
Mammalia Donson 33 16 34
  • 80 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DONSON 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DONSON 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves DONSON 33 34
  • 68.23 (n)
lizard
(Anolis carolinensis)
Reptilia DONSON 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia donson 33
  • 65.01 (n)
MGC76196 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6441 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.503 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005874 33
  • 48.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta hd 33 34
  • 46.99 (n)
CG2669 35
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
OneToOne
Species where no ortholog for DONSON was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DONSON Gene

ENSEMBL:
Gene Tree for DONSON (if available)
TreeFam:
Gene Tree for DONSON (if available)

Paralogs for DONSON Gene

Pseudogenes.org Pseudogenes for DONSON Gene

genes like me logo Genes that share paralogs with DONSON: view

No data available for Paralogs for DONSON Gene

Variants for DONSON Gene

Sequence variations from dbSNP and Humsavar for DONSON Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000162766 -- 33,578,202(+) AAGTT(-/A)ATGTT utr-variant-3-prime
rs1000164987 -- 33,588,282(+) CGAAA(C/G)ACAAG intron-variant
rs1000384402 -- 33,585,841(+) GGAAA(C/G)ACAAA intron-variant
rs1000604263 -- 33,579,753(+) TTTCC(A/C)TATTA intron-variant
rs1000681745 -- 33,578,560(+) TCCTA(G/T)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DONSON Gene

Variant ID Type Subtype PubMed ID
esv2723356 CNV deletion 23290073
esv2723357 CNV deletion 23290073

Variation tolerance for DONSON Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DONSON Gene

Human Gene Mutation Database (HGMD)
DONSON
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DONSON

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DONSON Gene

Disorders for DONSON Gene

MalaCards: The human disease database

(2) MalaCards diseases for DONSON Gene - From: OMIM and ClinVar

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DONSON

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DONSON
genes like me logo Genes that share disorders with DONSON: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DONSON Gene

Publications for DONSON Gene

  1. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. (PMID: 10773462) Slavov D … Gardiner K (Gene 2000) 2 3 4 60
  2. Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. (PMID: 28191891) Reynolds JJ … Stewart GS (Nature genetics 2017) 2 3 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman RT … Brenner SE (Genome biology 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for DONSON Gene

Sources for DONSON Gene

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