DOM3Z Gene
protein-coding GIFtS: 52
GCID: GC06M031937
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dom-3 homolog Z (C. elegans)(Previous name: DOM-3 (C. elegans) homolog Z )
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Aliases
for DOM3Z gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dom-3 Homolog Z (C. Elegans)1 2 | | RAI12 | | DOM3L2 3 | | Protein Dom3Z2 | | NG62 3 | | Dom-3 Homolog Z3 | | DOM-3 (C. Elegans) Homolog Z1 | | |
Export aliases for DOM3Z gene to outside databasesPrevious GC identifers: GC06M031999 GC06M031708 GC06M032041 GC06M032045 GC06M031725 |
Summaries
for DOM3Z gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DOM3Z:
This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of itsprotein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotessuggests that this may be a housekeeping gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DOM3Z_HUMAN, O77932Function: May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA (By similarity)
Gene Wiki entry for DOM3Z
|
Genomic Views
for DOM3Z gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167247.1 NT_167248.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DOM3Z gene promoter:
RFX1 STAT1 Pax-5 STAT1beta NF-kappaB STAT1alpha FOXO4 NF-kappaB1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DOM3Z
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOM3Z |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3DOM3Z Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M031937: view genomic region
(about GC identifiers)
Start:
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31,937,587 bp from pter |
End:
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31,940,069 bp from pter |
Size:
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2,483 bases |
Orientation:
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minus strand |
5 alternative locations:
| Chr6-,ALT_REF_LOCI_5 31,928,855-31,931,299 | Chr6-,ALT_REF_LOCI_6 31,927,979-31,966,005 | Chr6-,ALT_REF_LOCI_3 31,919,773-31,933,256 | | Chr6-,ALT_REF_LOCI_2 31,925,139-31,966,772 | Chr6-,ALT_REF_LOCI_7 31,859,763-31,862,207 |
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Proteins
for DOM3Z gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DOM3Z_HUMAN, O77932 (See
protein sequence)Recommended Name: Protein Dom3Z Size: 396 amino acids; 44929 Da
Sequence caution: Sequence=AAB67983.1; Type=Erroneous gene model prediction; Sequence=CAB89306.1; Type=Erroneous genemodel prediction;
Secondary accessions: A2CER3 B0UZ80 O15004 O78127 O78128 Q5ST60 Q6IPZ2 Q9NPK4Explore the universe of human proteins at neXtProt for DOM3Z: NX_O77932
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O77932
DOM3Z Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005501.2
ENSEMBL proteins: ENSP00000337759 ENSP00000364498 ENSP00000419588 ENSP00000364505 ENSP00000418632
Human Recombinant Protein Products:
DOM3Z Antibody Products:
Assay Products for DOM3Z: |
Protein
Domains /
Families
for DOM3Z gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DOM3Z for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O77932ProtoNet protein and cluster: O77932 1 Blocks protein family: IPB013961 RAI1 like
UniProtKB/Swiss-Prot: DOM3Z_HUMAN, O77932Similarity: Belongs to the Dom3Z family |
Function
for DOM3Z gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DOM3Z_HUMAN, O77932Function: May possess pyrophosphohydrolase activity towards 5' triphosphorylated RNA (By similarity) Genatlas biochemistry entry for DOM3Z:C elegans DOM3Z homolog,putatively involved in growth and reproduction
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOM3Z (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOM3Z (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DOM3Z (NM_005510) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOM3Z | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOM3Z |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOM3Z |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
DOM3Z for ontologies About GeneDecksing
|
Pathways & Interactions
for DOM3Z gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOM3Z
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for DOM3Z (O779322, 3 ENSP000003377594) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for DOM3Z gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DOM3Z
Search CenterWatch for drugs/clinical trials and news about DOM3Z
|
Transcripts
for DOM3Z gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DOM3Z gene: NM_005510.3 Unigene Cluster for DOM3Z: Dom-3 homolog Z (C. elegans) Hs.153299 [show with all ESTs]Unigene Representative Sequence: BC01908315 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000491327 ENST00000485557 ENST00000477826 ENST00000337523(uc003nyp.1 uc003nyq.1)
ENST00000375349(uc003nyu.1) ENST00000495340 ENST00000473976 ENST00000478221
ENST00000375356 ENST00000498357 ENST00000480240 ENST00000474587 ENST00000492946(uc010jtl.1)
ENST00000487914 ENST00000460058
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOM3Z (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOM3Z (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DOM3Z (NM_005510) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOM3Z | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOM3Z |
Additional cDNA sequence: AF059252.1 AF059253.1 AF059254.1 AK310107.1 BC009344.2 BC019083.2 BC050618.1 15 DOTS entries: DT.121361941 DT.112296 DT.100651906 DT.91752624 DT.95296222 DT.447275 DT.100651903 DT.100853230 DT.121361282 DT.95296223 DT.121361950 DT.91752618 DT.101982667 DT.100651904 DT.95296224 24/144 AceView cDNA sequences (see all 144): AF059252 BC071651 BC050618 F08347 BM701096 Z41353 NM_005510 CR622492 BC019083 BU687914 CD518827 AW006105 AI400743 AI208763 BC009344 BP873226 CB154762 BM833054 CR596930 CR590730 BC058885 CR622082 BM922282 AL542827
GeneLoc Exon Structure
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Expression
for DOM3Z gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DOM3Z expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTTCTGTG
About this image
See DOM3Z Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOM3Z
SOURCE GeneReport for Unigene cluster: Hs.153299
UniProtKB/Swiss-Prot: DOM3Z_HUMAN, O77932Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for DOM3Z
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOM3Z
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOM3Z | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOM3Z | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOM3Z | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOM3Z |
Orthologs
for DOM3Z gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DOM3Z gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for DOM3Z (if available)
TreeFam Gene Tree for DOM3Z (if available) |
Paralogs
for DOM3Z gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DOM3Z gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DOM3Z (31937587 - 31940069 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for DOM3Z
6 CNVs: 0599 3602 36508 36509 36507 4492
Human Gene Mutation Database (HGMD): DOM3Z
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOM3Z |
|
Disorders
/ Diseases
for DOM3Z gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DOM3Z for disorders About GeneDecksing
OMIM gene information: 605996
OMIM disorders: --
2  diseases for DOM3Z: About MalaCardsasphyxiating thoracic dystrophy gyrate atrophy
Human Genome Epidemiology (HuGE) Navigator: DOM3Z (6 documents)
Export disorders for DOM3Z gene to outside databases
|
Publications
for DOM3Z gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DOM3Z gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DOM3Z) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Four ubiquitously expressed genes, RD (D6S45)-SKI2W (SKIV2L)-DOM3Z- RP1 (D6S60E), are present between complement component genes factor B and C4 in the class III region of the HLA. (PubMed id 9799600)1, 2, 3 Yang Z.... Yu C.Y. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. (PubMed id 14656967)1, 2 Xie T.... Hood L. (2003)
- Organizations and gene duplications of the human and mouse MHC complement gene clusters. (PubMed id 10686478)1, 2 Yang Z. and Yu C.Y. (2000)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (2009)
- A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1 Lehner B. and Sanderson C.M. (2004)
- Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819)1 Lehner B....Sanderson C.M. (2004)
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External Searches for DOM3Z gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DOM3Z gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DOM3Z gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DOM3Z gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DOM3Z | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DOM3Z gene:
Search GeneIP for patents involving DOM3Z
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DOM3Z gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DOM3Z | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOM3Z | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOM3Z | | | OriGene Protein Over-expression Lysate for DOM3Z | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DOM3Z | | OriGene 3'-UTR Clone for DOM3Z | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOM3Z | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOM3Z | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DOM3Z | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DOM3Z | | OriGene Custom Protein Services for DOM3Z | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOM3Z | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOM3Z | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOM3Z | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOM3Z | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOM3Z | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOM3Z |
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| | | | Search Tocris compounds for DOM3Z |
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 | | | DOM3Z Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOM3Z |
|  |  |  | | | | ThermoFisher Antibodies for DOM3Z |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOM3Z |
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