DOLPP1 Gene
protein-coding GIFtS: 52
GCID: GC09P131844
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dolichyl pyrophosphate phosphatase 1
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Aliases for DOLPP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Dolichyl Pyrophosphate Phosphatase 11 2 3 | | LSFR21 2 3 | | EC 3.6.1.433 8 | | Dolichyldiphosphatase 12 | | Linked To Surfeit Genes In Fugu Rubripes 22 | | EC 3.6.18 |
Export aliases for DOLPP1 gene to outside databasesPrevious GC identifers: GC09P123489 GC09P125297 GC09P127219 GC09P128923 GC09P130883 GC09P101450 |
Summaries for DOLPP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DOLPP1: A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This proteindephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by theoligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variantsand protein isoforms. (provided by RefSeq, Jun 2012) UniProtKB/Swiss-Prot: DOPP1_HUMAN, Q86YN1Function: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linkedoligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lowerrate. Does not act on phosphatidate (By similarity)
|
Genomic Views for DOLPP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DOLPP1 gene promoter: HOXA9B HOXA9 USF1 Sox5 GATA-2 Meis-1b YY1 USF-1 c-Myb Meis-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for DOLPP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOLPP1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.1DOLPP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P131844: view genomic region
(about GC identifiers)
Start:
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131,843,379 bp from pter |
End:
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131,852,717 bp from pter |
Size:
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9,339 bases |
Orientation:
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plus strand |
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Proteins for DOLPP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DOPP1_HUMAN, Q86YN1 (See
protein sequence)Recommended Name: Dolichyldiphosphatase 1 Size: 238 amino acids; 27031 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=CAB44348.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K3U8 B0QZG4 Q96GF8 Q9Y3G1Alternative splicing: 2 isoforms: Q86YN1-1 Q86YN1-2 Explore the universe of human proteins at neXtProt for DOLPP1: NX_Q86YN1
4 DME Specific Peptides for DOLPP1 (Q86YN1)
DOLPP1 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_001129389.1 NP_065171.2 ENSEMBL proteins: ENSP00000361625 ENSP00000384043 ENSP00000333294 ENSP00000403278 ENSP00000440218 Reactome Protein details: Q86YN1 Human Recombinant Protein Products for DOLPP1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0030176 | integral to endoplasmic reticulum membrane |
ISS | -- |
DOLPP1 for ontologies About GeneDecksing
DOLPP1 Antibody Products: Assay Products for DOLPP1: |
Protein
Domains / Families for DOLPP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DOLPP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86YN1ProtoNet protein and cluster: Q86YN1 1 Blocks protein family: IPB000326 PA-phosphatase related phosphoesterase
UniProtKB/Swiss-Prot: DOPP1_HUMAN, Q86YN1Similarity: Belongs to the dolichyldiphosphatase family |
Function for DOLPP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: DOPP1_HUMAN, Q86YN1Function: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linkedoligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lowerrate. Does not act on phosphatidate (By similarity)Catalytic activity: Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate Enzyme Numbers (IUBMB): EC 3.6.1.431 2 EC 3.6.12
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0047874 | dolichyldiphosphatase activity |
ISS | -- |
DOLPP1 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for DOLPP1: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOLPP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOLPP1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DOLPP1 (NM_001135917) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOLPP1 |
|
Pathways & Interactions for DOLPP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Asparagine N-linked glycosylation | | | 2 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | | | 3 | Synthesis of Dolichyl-phosphate | |
Pathway sources See GeneCards unified pathways Show all pathways
5/6
Reactome Pathways for DOLPP1 (see all 6)
1
Kegg Pathway (Kegg details for DOLPP1): UniProtKB/Swiss-Prot: DOPP1_HUMAN, Q86YN1Pathway: Protein modification; protein glycosylation
DOLPP1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOLPP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
 5/11 Interacting proteins for DOLPP1 (ENSP000003616254) via UniProtKB, MINT, STRING, and/or I2D (see all 11) About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006487 | protein N-linked glycosylation |
ISS | -- | | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process |
TAS | -- | | GO:0006489 | dolichyl diphosphate biosynthetic process |
TAS | -- | | GO:0018279 | protein N-linked glycosylation via asparagine |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- |
DOLPP1 for ontologies About GeneDecksing
|
Drugs & Compounds for DOLPP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DOLPP1
5 HMDB Compounds for DOLPP1 About this table Search CenterWatch for drugs/clinical trials and news about DOLPP1 / DOPP1 
|
Transcripts for DOLPP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DOLPP1 gene (2 alternative transcripts): NM_001135917.1 NM_020438.4 Unigene Cluster for DOLPP1: Dolichyl pyrophosphate phosphatase 1 Hs.21701 [show with all ESTs]Unigene Representative Sequence: NM_0204386 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372546(uc004bxc.3 uc004bxd.3 uc004bxe.3) ENST00000406974 ENST00000327812 ENST00000412363 ENST00000480255 ENST00000540102
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOLPP1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOLPP1 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DOLPP1 (NM_001135917) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOLPP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOLPP1  |
Additional cDNA sequence: AK290713.1 AK293627.1 AY189675.1 BC009493.2 BC022553.1 BC033686.1 BC040152.1 BC067858.1 DQ655991.2 DQ655992.2 NR_072983.1 7 DOTS entries: DT.101981457 DT.97814291 DT.100750136 DT.454614 DT.315069 DT.100728568 DT.91743941 24/144 AceView cDNA sequences (see all 144): NM_020438 BC009493 BC022553 BQ425191 BF038648 BU742861 BM833320 BU624308 BQ186681 AW474451 BM726499 CA416688 BF515606 AA603748 BF941705 CR597048 BF981660 AI354360 BM980078 BX093232 BM679488 BX384141 BM721060 BC040152 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DOLPP1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   |
ECgene alternative splicing isoforms for DOLPP1
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Expression for DOLPP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DOLPP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTTCCCTCCC
 About this image See DOLPP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DOLPP1
SOURCE GeneReport for Unigene cluster: Hs.21701 SABiosciences Custom PCR Arrays for DOLPP1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOLPP1 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOLPP1 |
Orthologs for DOLPP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DOLPP1 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for DOLPP1 (if available) TreeFam Gene Tree for DOLPP1 (if available)  |
Paralogs for DOLPP1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for DOLPP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DOLPP1 (131843379 - 131852717 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for DOLPP1 1 CNV: 9623  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOLPP1 |
|
Disorders
/ Diseases for DOLPP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DOLPP1 for disorders About MalaCards
DOLPP1 for disorders About GeneDecksing
OMIM gene information: 614516
OMIM disorders: --
1 disease from the University of Copenhagen DISEASES database for DOLPP1:Batten disease Export disorders for DOLPP1 gene to outside databases
|
Publications for DOLPP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DOLPP1 gene integrated from 9 sources: (articles sorted by number of sources associating them with DOLPP1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PubMed id 10369878)1, 2, 3 Gilley J. and Fried M. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Identification and characterization of a cDNA encodin g a dolichyl pyrophosphate phosphatase located in the endoplasmic reticulum of mammalian cells. (PubMed id 12198133)1, 3 Rush J.S....Waechter C.J. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Enzymatic activities in cultured human lymphocytes th at dephosphorylate dolichyl pyrophosphate and dolichyl phosphate. (PubMed id 6243292)1 Wedgwood J.F. and Strominger J.L. (1980)
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External Searches for DOLPP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DOLPP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DOLPP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DOLPP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DOLPP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DOLPP1 gene: Search GeneIP for patents involving DOLPP1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DOLPP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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 | | DOLPP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOLPP1 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOLPP1 |
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