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Aliases for DOLPP1 Gene

Aliases for DOLPP1 Gene

  • Dolichyldiphosphatase 1 2 3
  • Dolichyl Pyrophosphate Phosphatase 1 2 3 4
  • LSFR2 3 4 6
  • Linked To Surfeit Genes In Fugu Rubripes 2 2 3
  • EC 3.6.1.43 4 64
  • EC 3.6.1 64

External Ids for DOLPP1 Gene

Summaries for DOLPP1 Gene

Entrez Gene Summary for DOLPP1 Gene

  • A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for DOLPP1 Gene

DOLPP1 (Dolichyldiphosphatase 1) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include dolichyldiphosphatase activity.

UniProtKB/Swiss-Prot for DOLPP1 Gene

  • Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOLPP1 Gene

Genomics for DOLPP1 Gene

Genomic Location for DOLPP1 Gene

Start:
129,081,100 bp from pter
End:
129,090,438 bp from pter
Size:
9,339 bases
Orientation:
Plus strand

Genomic View for DOLPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOLPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOLPP1 Gene

Regulatory Elements for DOLPP1 Gene

Proteins for DOLPP1 Gene

  • Protein details for DOLPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YN1-DOPP1_HUMAN
    Recommended name:
    Dolichyldiphosphatase 1
    Protein Accession:
    Q86YN1
    Secondary Accessions:
    • A8K3U8
    • B0QZG4
    • Q96GF8
    • Q9Y3G1

    Protein attributes for DOLPP1 Gene

    Size:
    238 amino acids
    Molecular mass:
    27031 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB44348.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DOLPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOLPP1 Gene

Proteomics data for DOLPP1 Gene at MOPED

Selected DME Specific Peptides for DOLPP1 Gene

Post-translational modifications for DOLPP1 Gene

No Post-translational modifications

Other Protein References for DOLPP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DOLPP1 Gene

Protein Domains for DOLPP1 Gene

UniProtKB/Swiss-Prot:

DOPP1_HUMAN
Family:
  • Belongs to the dolichyldiphosphatase family.:
    • Q86YN1
genes like me logo Genes that share domains with DOLPP1: view

No data available for Gene Families for DOLPP1 Gene

Function for DOLPP1 Gene

Molecular function for DOLPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate.
UniProtKB/Swiss-Prot Function: Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).

Enzyme Numbers (IUBMB) for DOLPP1 Gene

Gene Ontology (GO) - Molecular Function for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0047874 dolichyldiphosphatase activity ISS --
genes like me logo Genes that share ontologies with DOLPP1: view

Phenotypes for DOLPP1 Gene

genes like me logo Genes that share phenotypes with DOLPP1: view

miRNA for DOLPP1 Gene

miRTarBase miRNAs that target DOLPP1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DOLPP1 Gene

Localization for DOLPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOLPP1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOLPP1 Gene COMPARTMENTS Subcellular localization image for DOLPP1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane --
GO:0030176 integral component of endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with DOLPP1: view

Pathways for DOLPP1 Gene

genes like me logo Genes that share pathways with DOLPP1: view

UniProtKB/Swiss-Prot Q86YN1-DOPP1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for DOLPP1 Gene

Gene Ontology (GO) - Biological Process for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006487 protein N-linked glycosylation ISS --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006489 dolichyl diphosphate biosynthetic process TAS --
GO:0008610 lipid biosynthetic process IBA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with DOLPP1: view

Compounds for DOLPP1 Gene

(5) HMDB Compounds for DOLPP1 Gene

Compound Synonyms Cas Number PubMed IDs
Dolichol phosphate
  • dolichol-phosphate
34457-14-2
Dolichol-20
  • Dolichol (C100)
2067-66-5
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
Phosphate
  • NFB Orthophosphate
14265-44-2
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with DOLPP1: view

Transcripts for DOLPP1 Gene

Unigene Clusters for DOLPP1 Gene

Dolichyl pyrophosphate phosphatase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOLPP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -

Relevant External Links for DOLPP1 Gene

GeneLoc Exon Structure for
DOLPP1
ECgene alternative splicing isoforms for
DOLPP1

Expression for DOLPP1 Gene

mRNA expression in normal human tissues for DOLPP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOLPP1 Gene

SOURCE GeneReport for Unigene cluster for DOLPP1 Gene Hs.21701

genes like me logo Genes that share expressions with DOLPP1: view

Orthologs for DOLPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOLPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOLPP1 36
  • 100 (n)
  • 100 (a)
DOLPP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DOLPP1 36
  • 93.14 (n)
  • 95.8 (a)
DOLPP1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOLPP1 36
  • 94.82 (n)
  • 96.22 (a)
DOLPP1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dolpp1 36
  • 90.48 (n)
  • 94.12 (a)
Dolpp1 16
Dolpp1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOLPP1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOLPP1 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dolpp1 36
  • 91.97 (n)
  • 97.44 (a)
chicken
(Gallus gallus)
Aves DOLPP1 36
  • 78.71 (n)
  • 87.82 (a)
DOLPP1 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOLPP1 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14640 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dolpp1 36
  • 74.79 (n)
  • 81.93 (a)
Str.3212 36
zebrafish
(Danio rerio)
Actinopterygii dolpp1 36
  • 73.14 (n)
  • 75.95 (a)
dolpp1 37
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002666 36
  • 58.3 (n)
  • 57.53 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL186W 36
  • 42.18 (n)
  • 32.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAX4 36
  • 44.58 (n)
  • 36.87 (a)
CAX4 37
  • 30 (a)
OneToOne
CAX4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05687g 36
  • 44.13 (n)
  • 36.15 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03080 36
  • 44.96 (n)
  • 40.47 (a)
rice
(Oryza sativa)
Liliopsida Os03g0288700 36
  • 49.85 (n)
  • 40.74 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03718 36
  • 49.16 (n)
  • 41.01 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11001 37
  • 44 (a)
OneToOne
Species with no ortholog for DOLPP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOLPP1 Gene

ENSEMBL:
Gene Tree for DOLPP1 (if available)
TreeFam:
Gene Tree for DOLPP1 (if available)

Paralogs for DOLPP1 Gene

No data available for Paralogs for DOLPP1 Gene

Variants for DOLPP1 Gene

Sequence variations from dbSNP and Humsavar for DOLPP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1107530 -- 129,083,340(-) CCTCA(C/T)AGCAC intron-variant
rs3750335 -- 129,085,183(-) CAGGG(C/T)ATCAC intron-variant
rs3750336 -- 129,084,972(-) GGCTG(C/T)TACCT intron-variant
rs4411004 -- 129,090,873(+) CAGCA(C/G)TTTGG downstream-variant-500B
rs4836634 -- 129,087,384(+) GATCT(C/T)GGCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOLPP1 Gene

Variant ID Type Subtype PubMed ID
nsv893902 CNV Gain 21882294
nsv831729 CNV Loss 17160897
nsv509323 CNV Insertion 20534489
nsv818725 CNV Gain 17921354

Relevant External Links for DOLPP1 Gene

HapMap Linkage Disequilibrium report
DOLPP1

Disorders for DOLPP1 Gene

(1) University of Copenhagen DISEASES for DOLPP1 Gene

genes like me logo Genes that share disorders with DOLPP1: view

No data available for UniProtKB/Swiss-Prot for DOLPP1 Gene

Publications for DOLPP1 Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 2 3 4
  2. Identification and characterization of a cDNA encoding a dolichyl pyrophosphate phosphatase located in the endoplasmic reticulum of mammalian cells. (PMID: 12198133) Rush J.S. … Waechter C.J. (J. Biol. Chem. 2002) 2 3
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DOLPP1 Gene

Sources for DOLPP1 Gene

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