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Aliases for DOLPP1 Gene

Aliases for DOLPP1 Gene

  • Dolichyldiphosphatase 1 2 3 5
  • Dolichyl Pyrophosphate Phosphatase 1 2 3 4
  • Linked To Surfeit Genes In Fugu Rubripes 2 2 3
  • EC 3.6.1.43 4 61
  • LSFR2 3 4
  • EC 3.6.1 61

External Ids for DOLPP1 Gene

Previous GeneCards Identifiers for DOLPP1 Gene

  • GC09P123489
  • GC09P125297
  • GC09P127219
  • GC09P128923
  • GC09P130883
  • GC09P131844
  • GC09P101450

Summaries for DOLPP1 Gene

Entrez Gene Summary for DOLPP1 Gene

  • A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for DOLPP1 Gene

DOLPP1 (Dolichyldiphosphatase 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include dolichyldiphosphatase activity.

UniProtKB/Swiss-Prot for DOLPP1 Gene

  • Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOLPP1 Gene

Genomics for DOLPP1 Gene

Regulatory Elements for DOLPP1 Gene

Enhancers for DOLPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F129197 1 Ensembl ENCODE 5.8 +117.4 117436 1.7 CTCF L3MBTL2 RAD21 NR2F2 ZBTB48 POLR2A IKZF1 ZBTB33 FOS TCF7L2 IER5L LOC105376289 CRAT ENSG00000268707 DOLPP1 GC09M129195 LOC105376290
GH09F129401 1.4 FANTOM5 Ensembl ENCODE 5 +324.3 324253 8.7 HDGF PKNOX1 ARNT SIN3A CBX5 ZNF143 KLF13 DEK ZNF263 SP3 DOLPP1 ENSG00000236146 LOC105376291
GH09F129960 0.9 Ensembl ENCODE 4.9 +882.9 882891 6.3 TBP IRF2 PKNOX1 TBL1XR1 WRNIP1 ZNF175 ZNF266 ZIC2 ETS1 ZNF335 FNBP1 TOR1A ENSG00000230684 USP20 C9orf78 TOR1B DOLPP1
GH09F129554 1.5 FANTOM5 Ensembl ENCODE 1.5 +476.1 476101 6.0 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 PAF1 SP5 NFYC MXD4 NTMT1 C9orf50 IER5L LOC105376289 PKN3 ENSG00000270755 DOLPP1 LOC105376292 LINC00963
GH09F129079 0.2 ENCODE 0.8 +0.1 118 2.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS KLF13 CEBPZ LOC101929314 SPTAN1 USP20 SPOUT1 ENSG00000272696 LOC105376289 ENSG00000272593 C9orf50 URM1 DOLPP1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DOLPP1 on UCSC Golden Path with GeneCards custom track

Promoters for DOLPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001315330 -100 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS KLF13 CEBPZ

Genomic Location for DOLPP1 Gene

Chromosome:
9
Start:
129,081,100 bp from pter
End:
129,090,438 bp from pter
Size:
9,339 bases
Orientation:
Plus strand

Genomic View for DOLPP1 Gene

Genes around DOLPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOLPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOLPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOLPP1 Gene

Proteins for DOLPP1 Gene

  • Protein details for DOLPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YN1-DOPP1_HUMAN
    Recommended name:
    Dolichyldiphosphatase 1
    Protein Accession:
    Q86YN1
    Secondary Accessions:
    • A8K3U8
    • B0QZG4
    • Q96GF8
    • Q9Y3G1

    Protein attributes for DOLPP1 Gene

    Size:
    238 amino acids
    Molecular mass:
    27031 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB44348.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DOLPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOLPP1 Gene

Selected DME Specific Peptides for DOLPP1 Gene

Q86YN1:
  • YGMPSSHSQFM
  • IVGFVTLIIFKRELHTISFLGGL
  • LVSYSRVY
  • VIQEPRPCGGPH

Post-translational modifications for DOLPP1 Gene

No Post-translational modifications

Other Protein References for DOLPP1 Gene

Domains & Families for DOLPP1 Gene

Gene Families for DOLPP1 Gene

Protein Domains for DOLPP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YN1

UniProtKB/Swiss-Prot:

DOPP1_HUMAN :
  • Belongs to the dolichyldiphosphatase family.
Family:
  • Belongs to the dolichyldiphosphatase family.
genes like me logo Genes that share domains with DOLPP1: view

Function for DOLPP1 Gene

Molecular function for DOLPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).

Enzyme Numbers (IUBMB) for DOLPP1 Gene

Gene Ontology (GO) - Molecular Function for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0047874 dolichyldiphosphatase activity TAS --
genes like me logo Genes that share ontologies with DOLPP1: view
genes like me logo Genes that share phenotypes with DOLPP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DOLPP1

miRNA for DOLPP1 Gene

miRTarBase miRNAs that target DOLPP1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOLPP1 Gene

Localization for DOLPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOLPP1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOLPP1 Gene COMPARTMENTS Subcellular localization image for DOLPP1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytoskeleton 2
lysosome 1

Gene Ontology (GO) - Cellular Components for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane ISS,IBA --
genes like me logo Genes that share ontologies with DOLPP1: view

Pathways & Interactions for DOLPP1 Gene

genes like me logo Genes that share pathways with DOLPP1: view

UniProtKB/Swiss-Prot Q86YN1-DOPP1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation ISS,IBA --
GO:0006489 dolichyl diphosphate biosynthetic process TAS --
GO:0008610 lipid biosynthetic process IBA --
genes like me logo Genes that share ontologies with DOLPP1: view

No data available for SIGNOR curated interactions for DOLPP1 Gene

Drugs & Compounds for DOLPP1 Gene

(3) Drugs for DOLPP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
dolichol phosphate Pharma Competitive, Inhibitor 0

(3) Additional Compounds for DOLPP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichol-20
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
2067-66-5
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DOLPP1: view

Transcripts for DOLPP1 Gene

Unigene Clusters for DOLPP1 Gene

Dolichyl pyrophosphate phosphatase 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOLPP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -

Relevant External Links for DOLPP1 Gene

GeneLoc Exon Structure for
DOLPP1
ECgene alternative splicing isoforms for
DOLPP1

Expression for DOLPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DOLPP1 Gene

Protein differential expression in normal tissues from HIPED for DOLPP1 Gene

This gene is overexpressed in Fetal Brain (12.3), Ovary (8.3), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOLPP1 Gene



Protein tissue co-expression partners for DOLPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DOLPP1 Gene:

DOLPP1

SOURCE GeneReport for Unigene cluster for DOLPP1 Gene:

Hs.21701
genes like me logo Genes that share expression patterns with DOLPP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DOLPP1 Gene

Orthologs for DOLPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOLPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOLPP1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia DOLPP1 34 35
  • 94.82 (n)
cow
(Bos Taurus)
Mammalia DOLPP1 34 35
  • 93.14 (n)
oppossum
(Monodelphis domestica)
Mammalia DOLPP1 35
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dolpp1 34
  • 91.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DOLPP1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dolpp1 34 16 35
  • 90.48 (n)
chicken
(Gallus gallus)
Aves DOLPP1 34 35
  • 78.71 (n)
lizard
(Anolis carolinensis)
Reptilia DOLPP1 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dolpp1 34
  • 74.79 (n)
Str.3212 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14640 34
zebrafish
(Danio rerio)
Actinopterygii dolpp1 34 35
  • 73.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002666 34
  • 58.3 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAX4 34 35 37
  • 44.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05687g 34
  • 44.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL186W 34
  • 42.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03080 34
  • 44.96 (n)
rice
(Oryza sativa)
Liliopsida Os03g0288700 34
  • 49.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03718 34
  • 49.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11001 35
  • 44 (a)
OneToOne
Species where no ortholog for DOLPP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOLPP1 Gene

ENSEMBL:
Gene Tree for DOLPP1 (if available)
TreeFam:
Gene Tree for DOLPP1 (if available)

Paralogs for DOLPP1 Gene

No data available for Paralogs for DOLPP1 Gene

Variants for DOLPP1 Gene

Sequence variations from dbSNP and Humsavar for DOLPP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10760586 -- 129,081,648(+) CTCCC(C/G)GTTGC intron-variant
rs10760587 -- 129,083,737(+) ATGCA(C/G)CTGTA intron-variant
rs10819461 -- 129,079,608(+) TCCCA(C/T)GCAGC upstream-variant-2KB
rs10988198 -- 129,083,846(+) AACCA(C/T)GCTCT intron-variant
rs10988199 -- 129,084,495(+) GTATG(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOLPP1 Gene

Variant ID Type Subtype PubMed ID
nsv509323 CNV insertion 20534489
nsv818725 CNV gain 17921354
nsv831729 CNV loss 17160897

Variation tolerance for DOLPP1 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOLPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOLPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOLPP1 Gene

Disorders for DOLPP1 Gene

Relevant External Links for DOLPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOLPP1

No disorders were found for DOLPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOLPP1 Gene

Publications for DOLPP1 Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 2 3 4 64
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification and characterization of a cDNA encoding a dolichyl pyrophosphate phosphatase located in the endoplasmic reticulum of mammalian cells. (PMID: 12198133) Rush J.S. … Waechter C.J. (J. Biol. Chem. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for DOLPP1 Gene

Sources for DOLPP1 Gene

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