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Aliases for DOLPP1 Gene

Aliases for DOLPP1 Gene

  • Dolichyldiphosphatase 1 2 3 5
  • Dolichyl Pyrophosphate Phosphatase 1 2 3 4
  • Linked To Surfeit Genes In Fugu Rubripes 2 2 3
  • EC 3.6.1.43 4 58
  • LSFR2 3 4
  • EC 3.6.1 58

External Ids for DOLPP1 Gene

Previous GeneCards Identifiers for DOLPP1 Gene

  • GC09P123489
  • GC09P125297
  • GC09P127219
  • GC09P128923
  • GC09P130883
  • GC09P131844
  • GC09P101450

Summaries for DOLPP1 Gene

Entrez Gene Summary for DOLPP1 Gene

  • A similar gene has been characterized in mice and encodes dolichyl pyrophosphate (Dol-P-P) phosphatase. This protein dephosphorylates dolichyl pyrophosphate so that it may be re-utilized as a glycosyl carrier lipid by the oligosaccharyltransferase multisubunit complex in the ER. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for DOLPP1 Gene

DOLPP1 (Dolichyldiphosphatase 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and N-Glycan biosynthesis. GO annotations related to this gene include dolichyldiphosphatase activity.

UniProtKB/Swiss-Prot for DOLPP1 Gene

  • Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).

Additional gene information for DOLPP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOLPP1 Gene

Genomics for DOLPP1 Gene

Regulatory Elements for DOLPP1 Gene

Enhancers for DOLPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H129401 2 FANTOM5 Ensembl ENCODE dbSUPER 5 +324.4 324353 8 HDGF PKNOX1 ATF1 ARNT SIN3A BRCA1 ZBTB7B GLIS2 ELK1 ATF7 DOLPP1 ENSG00000236146 LOC105376291
GH09H129197 1.1 Ensembl ENCODE dbSUPER 5.8 +117.4 117410 1 FOSL1 ZNF3 L3MBTL2 ZBTB48 IKZF1 ZBTB33 RAD21 NR2F2 LOC105376289 IER5L CRAT ENSG00000268707 DOLPP1 GC09M129195 LOC105376290
GH09H129960 1.3 Ensembl ENCODE dbSUPER 4.9 +882.9 882891 6 TBP PKNOX1 IRF2 TBL1XR1 TAF1 ZNF175 ETS1 POLR2A ZNF366 ETV6 FNBP1 TOR1A ENSG00000230684 USP20 C9orf78 TOR1B DOLPP1
GH09H129555 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.5 +476.8 476842 4 FOXA2 MLX ZFP64 ARID4B DMAP1 ZBTB7B YY1 SLC30A9 PAF1 SP5 NTMT1 C9orf50 IER5L LOC105376289 PKN3 DOLPP1 LOC105376292 LINC00963
GH09H129079 1.1 ENCODE 0.7 +0.1 118 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143 NUP188 ODF2 GLE1 CIZ1 URM1 DOLPP1 ENSG00000234055
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOLPP1 on UCSC Golden Path with GeneCards custom track

Promoters for DOLPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241947 0 1401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143

Genomic Location for DOLPP1 Gene

Chromosome:
9
Start:
129,081,100 bp from pter
End:
129,090,438 bp from pter
Size:
9,339 bases
Orientation:
Plus strand

Genomic View for DOLPP1 Gene

Genes around DOLPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOLPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOLPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOLPP1 Gene

Proteins for DOLPP1 Gene

  • Protein details for DOLPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YN1-DOPP1_HUMAN
    Recommended name:
    Dolichyldiphosphatase 1
    Protein Accession:
    Q86YN1
    Secondary Accessions:
    • A8K3U8
    • B0QZG4
    • Q96GF8
    • Q9Y3G1

    Protein attributes for DOLPP1 Gene

    Size:
    238 amino acids
    Molecular mass:
    27031 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB44348.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for DOLPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOLPP1 Gene

Selected DME Specific Peptides for DOLPP1 Gene

Q86YN1:
  • YGMPSSHSQFM
  • IVGFVTLIIFKRELHTISFLGGL
  • LVSYSRVY
  • VIQEPRPCGGPH

Post-translational modifications for DOLPP1 Gene

No Post-translational modifications

Other Protein References for DOLPP1 Gene

Domains & Families for DOLPP1 Gene

Gene Families for DOLPP1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for DOLPP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YN1

UniProtKB/Swiss-Prot:

DOPP1_HUMAN :
  • Belongs to the dolichyldiphosphatase family.
Family:
  • Belongs to the dolichyldiphosphatase family.
genes like me logo Genes that share domains with DOLPP1: view

Function for DOLPP1 Gene

Molecular function for DOLPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl diphosphate + H(2)O = dolichyl phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate (By similarity).

Enzyme Numbers (IUBMB) for DOLPP1 Gene

Phenotypes From GWAS Catalog for DOLPP1 Gene

Gene Ontology (GO) - Molecular Function for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0047874 dolichyldiphosphatase activity TAS --
genes like me logo Genes that share ontologies with DOLPP1: view
genes like me logo Genes that share phenotypes with DOLPP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DOLPP1

CRISPR Products

miRNA for DOLPP1 Gene

miRTarBase miRNAs that target DOLPP1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOLPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOLPP1 Gene

Localization for DOLPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOLPP1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOLPP1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytoskeleton 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with DOLPP1: view

Pathways & Interactions for DOLPP1 Gene

genes like me logo Genes that share pathways with DOLPP1: view

UniProtKB/Swiss-Prot Q86YN1-DOPP1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for DOLPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006487 protein N-linked glycosylation ISS --
GO:0006489 dolichyl diphosphate biosynthetic process TAS --
GO:0008610 lipid biosynthetic process IBA --
genes like me logo Genes that share ontologies with DOLPP1: view

No data available for SIGNOR curated interactions for DOLPP1 Gene

Drugs & Compounds for DOLPP1 Gene

(3) Drugs for DOLPP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
dolichol phosphate Pharma Competitive, Inhibitor 0

(3) Additional Compounds for DOLPP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichol-20
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
2067-66-5
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
genes like me logo Genes that share compounds with DOLPP1: view

Transcripts for DOLPP1 Gene

Unigene Clusters for DOLPP1 Gene

Dolichyl pyrophosphate phosphatase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOLPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DOLPP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - -

Relevant External Links for DOLPP1 Gene

GeneLoc Exon Structure for
DOLPP1
ECgene alternative splicing isoforms for
DOLPP1

Expression for DOLPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOLPP1 Gene

Protein differential expression in normal tissues from HIPED for DOLPP1 Gene

This gene is overexpressed in Fetal Brain (12.3), Ovary (8.3), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOLPP1 Gene



Protein tissue co-expression partners for DOLPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DOLPP1 Gene:

DOLPP1

SOURCE GeneReport for Unigene cluster for DOLPP1 Gene:

Hs.21701

Evidence on tissue expression from TISSUES for DOLPP1 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DOLPP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOLPP1 Gene

Orthologs for DOLPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOLPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOLPP1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia DOLPP1 33 34
  • 94.82 (n)
cow
(Bos Taurus)
Mammalia DOLPP1 33 34
  • 93.14 (n)
oppossum
(Monodelphis domestica)
Mammalia DOLPP1 34
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dolpp1 33
  • 91.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DOLPP1 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dolpp1 33 16 34
  • 90.48 (n)
chicken
(Gallus gallus)
Aves DOLPP1 33 34
  • 78.71 (n)
lizard
(Anolis carolinensis)
Reptilia DOLPP1 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dolpp1 33
  • 74.79 (n)
Str.3212 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14640 33
zebrafish
(Danio rerio)
Actinopterygii dolpp1 33 34
  • 73.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002666 33
  • 58.3 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAX4 33 34 36
  • 44.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05687g 33
  • 44.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL186W 33
  • 42.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03080 33
  • 44.96 (n)
rice
(Oryza sativa)
Liliopsida Os03g0288700 33
  • 49.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03718 33
  • 49.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11001 34
  • 44 (a)
OneToOne
Species where no ortholog for DOLPP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOLPP1 Gene

ENSEMBL:
Gene Tree for DOLPP1 (if available)
TreeFam:
Gene Tree for DOLPP1 (if available)

Paralogs for DOLPP1 Gene

No data available for Paralogs for DOLPP1 Gene

Variants for DOLPP1 Gene

Sequence variations from dbSNP and Humsavar for DOLPP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000059370 -- 129,083,164(+) GGGGA(A/G)CTTGT intron-variant
rs1000148096 -- 129,089,346(+) CAGGA(A/G)TTCCA nc-transcript-variant, utr-variant-3-prime
rs1000233172 -- 129,088,479(+) CTCTG(A/G)ATATA intron-variant
rs1000603829 -- 129,087,616(+) CGGCC(A/G)AAGGC intron-variant
rs1000804739 -- 129,079,137(+) GGATT(C/T)CCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DOLPP1 Gene

Variant ID Type Subtype PubMed ID
nsv509323 CNV insertion 20534489
nsv818725 CNV gain 17921354
nsv831729 CNV loss 17160897

Variation tolerance for DOLPP1 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOLPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOLPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOLPP1 Gene

Disorders for DOLPP1 Gene

Relevant External Links for DOLPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOLPP1

No disorders were found for DOLPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOLPP1 Gene

Publications for DOLPP1 Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J … Fried M (Human molecular genetics 1999) 2 3 4 60
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Identification and characterization of a cDNA encoding a dolichyl pyrophosphate phosphatase located in the endoplasmic reticulum of mammalian cells. (PMID: 12198133) Rush JS … Waechter CJ (The Journal of biological chemistry 2002) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for DOLPP1 Gene

Sources for DOLPP1 Gene

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