DOLK Gene
protein-coding GIFtS: 53
GCID: GC09M131707
|
|
dolichol kinase(Previous name: transmembrane protein 15 )
(Previous symbol: TMEM15)
| |
Aliases
for DOLK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dolichol Kinase1 2 | | SEC592 5 | | TMEM151 2 3 5 | | DK2 | | Transmembrane Protein 151 2 3 | | Dolichol Kinase 12 | | DK11 2 5 | | SEC59 Homolog2 | | KIAA10941 3 5 | | EC 2.7.1.1083 | | CDG1M2 5 | | |
Export aliases for DOLK gene to outside databasesPrevious GC identifers: GC09M130749 GC09M101315 |
Summaries
for DOLK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DOLK:
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in thesynthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linkedglycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum.Mutations in this gene are associated with dolichol kinase deficiency.(provided by RefSeq, Apr 2010)
UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8Function: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked andO-linked oligosaccharides and for that of GPI anchors (By similarity)
Gene Wiki entry for DOLK (Dolichol kinase)
|
Genomic Views
for DOLK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DOLK gene promoter:
AML1a POU2F1 POU2F1a FOXD3 FOXJ2 HNF-3beta C/EBPalpha FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DOLK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOLK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.13DOLK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M131707: view genomic region
(about GC identifiers)
Start:
|
131,707,809 bp from pter |
End:
|
131,710,012 bp from pter |
Size:
|
2,204 bases |
Orientation:
|
minus strand |
|
Proteins
for DOLK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8 (See
protein sequence)Recommended Name: Dolichol kinase Size: 538 amino acids; 59268 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at therestrictive temperature in yeast sec59 mutant cells
Sequence caution: Sequence=BAA83046.2; Type=Erroneous initiation;
Secondary accessions: Q5SRE6Explore the universe of human proteins at neXtProt for DOLK: NX_Q9UPQ8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UPQ8
DOLK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055723.1
ENSEMBL proteins: ENSP00000361667 Reactome Protein details: Q9UPQ8
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0030176 | integral to endoplasmic reticulum membrane |
IDA | 16923818 |
DOLK for ontologies About GeneDecksing
DOLK Antibody Products:
Assay Products for DOLK: |
Protein
Domains /
Families
for DOLK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DOLK for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UPQ8ProtoNet protein and cluster: Q9UPQ8 1 Blocks protein family: IPB000374 Phosphatidate cytidylyltransferase
UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8Similarity: Belongs to the polyprenol kinase family |
Function
for DOLK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8Function: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked andO-linked oligosaccharides and for that of GPI anchors (By similarity)Catalytic activity: CTP + dolichol = CDP + dolichyl phosphateEnzyme Number (IUBMB): EC 2.7.1.1081
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOLK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOLK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DOLK (NM_014908) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOLK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOLK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOLK |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
DOLK for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Dolktm1Lex for DOLK
1 MGI phenotypic allele  for Dolk (no phenotypes)
DOLK for phenotypes About GeneDecksing
|
Pathways & Interactions
for DOLK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Asparagine N-linked glycosylation | | | 2 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | | | 3 | dolichol and dolichyl phosphate biosynthesis | | | 4 | Synthesis of Dolichyl-phosphate | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for DOLK
5/6 
Reactome Pathways for DOLK (see all 6)
2 
Kegg Pathways (Kegg details for DOLK):
DOLK for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOLK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/8 Interacting proteins for DOLK (Q9UPQ83 ENSP000003616674) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic process |
TAS | -- | | GO:0006489 | dolichyl diphosphate biosynthetic process |
TAS | -- | | GO:0018279 | protein N-linked glycosylation via asparagine |
TAS | -- | | GO:0043048 | dolichyl monophosphate biosynthetic process |
IDA | 12213788 | | GO:0043687 | post-translational protein modification |
TAS | -- |
DOLK for ontologies About GeneDecksing
|
Drugs & Compounds
for DOLK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DOLK
2 HMDB Compounds for DOLK About this table
Search CenterWatch for drugs/clinical trials and news about DOLK
|
Transcripts
for DOLK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DOLK gene: NM_014908.3 Unigene Cluster for DOLK: Dolichol kinase Hs.531563 [show with all ESTs]Unigene Representative Sequence: NM_0149081 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372586(uc004bwr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOLK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOLK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DOLK (NM_014908) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOLK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOLK |
Additional cDNA sequence: AB029017.1 AK225402.1 AK300180.1 AY358759.1 BC035556.1 5 DOTS entries: DT.40214549 DT.100777144 DT.100777140 DT.100677596 DT.95173009 24/431 AceView cDNA sequences (see all 431): Z41514 AL523184 AW072128 BQ921840 BQ943880 BE887545 BG035436 D79991 BQ052588 BQ064804 BM695810 BG392063 BM671848 BU187325 BQ055344 BX325410 BQ071308 BG391475 BQ683960 CA396162 BE260478 BM918033 BQ057053 BC040352
GeneLoc Exon Structure
|
Expression
for DOLK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DOLK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAGCCAAG
About this image
See DOLK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOLK
SOURCE GeneReport for Unigene cluster: Hs.531563
UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for DOLK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOLK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOLK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOLK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOLK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOLK |
Orthologs
for DOLK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DOLK gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for DOLK (if available)
TreeFam Gene Tree for DOLK (if available) |
Paralogs
for DOLK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DOLK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DOLK (131707809 - 131710012 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DOLK: --
Human Gene Mutation Database (HGMD): DOLK
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOLK |
|
Disorders
/ Diseases
for DOLK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DOLK for disorders About GeneDecksing
OMIM gene information: 610746
OMIM disorders: 610768
UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8
Defects in DOLK are the cause of congenital disorder of glycosylation type 1M (CDG1M) [MIM:610768]; also knownas dolichol kinase deficiency. CDGs are a family of severe inherited diseases caused by a defect in glycoproteinbiosynthesis. They are characterized by under-glycosylated serum glycoproteins. These multisystem disorders presentwith a wide variety of clinical features, such as disorders of the nervous system development, psychomotorretardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum offeatures reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenanceof cell functions. CDG1M is a very severe disorder with death occurring in early infancy
3  diseases for DOLK: About MalaCardscongenital disorder of glycosylation hypotonia malaria
GeneTests: DOLK
Congenital Disorders of Glycosylation
Export disorders for DOLK gene to outside databases
|
Publications
for DOLK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DOLK gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with DOLK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site. (PubMed id 16923818)1, 2, 3 Shridas P. and Waechter C.J. (2006)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy. (PubMed id 17273964)1, 2 Kranz C.... Marquardt T. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae. (PubMed id 12213788)1, 2 Fernandez F.... Waechter C.J. (2002)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- Autosomal recessive dilated cardiomyopathy due to DOLK mutations results from abnormal dystroglycan O-mannosylation. (PubMed id 22242004)1 Lefeber D.J....Wevers R.A. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DOLK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DOLK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DOLK gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DOLK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DOLK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DOLK gene:
Search GeneIP for patents involving DOLK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DOLK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DOLK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOLK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOLK | | | OriGene Protein Over-expression Lysate for DOLK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DOLK | | OriGene 3'-UTR Clone for DOLK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOLK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOLK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DOLK | | OriGene Custom Protein Services for DOLK | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOLK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOLK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOLK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOLK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOLK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOLK |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DOLK |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DOLK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOLK |
|  |  |  | | | | Search ThermoFisher Antibodies for DOLK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOLK |
|
|
|
|
