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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOLK Gene

protein-coding   GIFtS: 54
GCID: GC09M131707

Dolichol Kinase

(Previous name: transmembrane protein 15)
(Previous symbol: TMEM15)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dolichol Kinase1 2     SEC592 5
TMEM151 2 3 5     KIAA10943 5
Transmembrane Protein 151 2 3     DK2
Dolichol Kinase 11 2     SEC59 Homolog2
CDG1M2 5     EC 2.7.1.1083
DK12 5     

External Ids:    HGNC: 234061   Entrez Gene: 228452   Ensembl: ENSG000001752837   OMIM: 6107465   UniProtKB: Q9UPQ83   

Export aliases for DOLK gene to outside databases

Previous GC identifers: GC09M130749 GC09M101315


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOLK Gene:
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the
synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked
glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic
reticulum. Mutations in this gene are associated with dolichol kinase deficiency.(provided by RefSeq, Apr 2010)

GeneCards Summary for DOLK Gene: 
DOLK (dolichol kinase) is a protein-coding gene. Diseases associated with DOLK include congenital disorder of glycosylation, type im, and hypotonia, and among its related super-pathways are WNT ligand biogenesis and trafficking and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include dolichol kinase activity.

UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8
Function: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked
and O-linked oligosaccharides and for that of GPI anchors (By similarity)

Gene Wiki entry for DOLK (Dolichol kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOLK gene promoter:
         AML1a   POU2F1   POU2F1a   FOXD3   FOXJ2   HNF-3beta   C/EBPalpha   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOLK promoter sequence
   Search SABiosciences Chromatin IP Primers for DOLK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOLK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

DOLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOLK gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131707:  view genomic region     (about GC identifiers)

Start:
131,707,809 bp from pter      End:
131,710,012 bp from pter
Size:
2,204 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8 (See protein sequence)
Recommended Name: Dolichol kinase  
Size: 538 amino acids; 59268 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Miscellaneous: Complements the defects in growth, dolichol kinase activity and protein N-glycosylation at the
restrictive temperature in yeast sec59 mutant cells
Sequence caution: Sequence=BAA83046.2; Type=Erroneous initiation;
Secondary accessions: Q5SRE6

Explore the universe of human proteins at neXtProt for DOLK: NX_Q9UPQ8

Explore proteomics data for DOLK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPQ8

  • DOLK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOLK Protein Expression
    REFSEQ proteins: NP_055723.1  
    ENSEMBL proteins: 
     ENSP00000361667  
    Reactome Protein details: Q9UPQ8
    Human Recombinant Protein Products for DOLK: 
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    Novus Biologicals DOLK Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOLK 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0030176integral to endoplasmic reticulum membrane IDA16923818

    DOLK for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026566 DOLK

    Graphical View of Domain Structure for InterPro Entry Q9UPQ8

    ProtoNet protein and cluster: Q9UPQ8

    1 Blocks protein domain: IPB000374 Phosphatidate cytidylyltransferase

    UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8
    Similarity: Belongs to the polyprenol kinase family


    DOLK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOLK_HUMAN, Q9UPQ8
    Function: Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked
    and O-linked oligosaccharides and for that of GPI anchors (By similarity)
    Catalytic activity: CTP + dolichol = CDP + dolichyl phosphate

         Enzyme Number (IUBMB): EC 2.7.1.1081

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004168dolichol kinase activity IDA12213788
         
    DOLK for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Dolk (no phenotypes)

    DOLK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dolktm1Lex for DOLK

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOLK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOLK

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    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DOLK About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.53
    Synthesis of substrates in N-glycan biosythesis0.53
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40
    5dolichol and dolichyl phosphate biosynthesis
    dolichol and dolichyl phosphate biosynthesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DOLK
        dolichol and dolichyl phosphate biosynthesis

    5/9        Reactome Pathways for DOLK (see all 9)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Synthesis of Dolichyl-phosphate
    Synthesis of substrates in N-glycan biosythesis


    2         Kegg Pathways  (Kegg details for DOLK):
        N-Glycan biosynthesis
    Metabolic pathways


    DOLK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOLK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for DOLK (Q9UPQ83 ENSP000003616674) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    ALG5ENSP000002398914STRING: ENSP00000239891
    DOLPP1ENSP000003616254STRING: ENSP00000361625
    DPAGT1ENSP000003461424STRING: ENSP00000346142
    DPM1ENSP000003606444STRING: ENSP00000360644
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
    GO:0006489dolichyl diphosphate biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043048dolichyl monophosphate biosynthetic process IDA12213788
    GO:0043687post-translational protein modification TAS--

    DOLK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOLK

    2 HMDB Compounds for DOLK    About this table
    CompoundSynonyms CAS #PubMed Ids
    CDPCDP (see all 3)63-38-7--
    Dolichol-20Dolichol (C100) (see all 5)2067-66-5--

    Search CenterWatch for drugs/clinical trials and news about DOLK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOLK gene: 
    NM_014908.3  

    Unigene Cluster for DOLK:

    Dolichol kinase
    Hs.531563  [show with all ESTs]
    Unigene Representative Sequence: NM_014908
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372586(uc004bwr.3)
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DOLK (NM_014908)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOLK

    Additional mRNA sequence: 

    AB029017.1 AK225402.1 AK300180.1 AY358759.1 BC035556.1 

    5 DOTS entries:

    DT.40214549  DT.100777144  DT.100777140  DT.100677596  DT.95173009 

    24/431 AceView cDNA sequences (see all 431):

    BF058618 BQ058021 AL046739 BG035436 BM561059 BM782516 BU196907 BU187325 
    AL046732 AL043359 BG106615 AK025292 BQ943880 BM558153 AA767508 BM695810 
    BU552569 BQ073271 BG392063 BM974449 BG391475 BQ063289 D79991 BE206717 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOLK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGCCAAG
    DOLK Expression
    About this image


    See DOLK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOLK

    SOURCE GeneReport for Unigene cluster: Hs.531563

    UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DOLK gene from 9/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dolk1 , 5 dolichol kinase1, 5 88.7(n)1
    95.32(a)1
      2 (21.49 cM)5
    2276971  NM_177648.31  NP_808316.11 
     302842315 
    chicken
    (Gallus gallus)
    Aves DOLK1 dolichol kinase 70.25(n)
    78.5(a)
      417199  XM_415482.2  XP_415482.1 
    lizard
    (Anolis carolinensis)
    Reptilia DOLK6
    Uncharacterized protein
    73(a)
    1 ↔ 1
    AAWZ02037988(3846-5468)
    zebrafish
    (Danio rerio)
    Actinopterygii dolk1 dolichol kinase 62.99(n)
    65.96(a)
      799960  NM_001110484.1  NP_001103954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG83111 CG8311 44.14(n)
    34.17(a)
      36856  NM_137295.2  NP_611139.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y56A3A.361 Protein Y56A3A.36 44.55(n)
    36.1(a)
      3565503  NM_001027754.1  NP_001022925.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC59(YMR013C)4 Dolichol kinase, catalyzes the terminal step in dolichyl more   --   13(296738-295179) 855026  NP_013726.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G450401 dolichol kinase 43.08(n)
    33.47(a)
      823639  NM_114373.3  NP_190090.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g01465001 hypothetical protein 46.69(n)
    42.41(a)
      4328285  NM_001052412.1  NP_001045877.1 


    ENSEMBL Gene Tree for DOLK (if available)
    TreeFam Gene Tree for DOLK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/20 SNPs in DOLK are shown (see all 20)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0328524
    Congenital disorder of glycosylation 1M (CDG1M)4--see VAR_0328522 Y S mis40--------
    VAR_0328514
    Congenital disorder of glycosylation 1M (CDG1M)4--see VAR_0328512 C S mis40--------
    VAR_0497094
    ----see VAR_0497092 D V mis40--------
    rs1443788451,2
    --101315044(+) TTAGTC/TTGACC 1 -- ds50010--------
    rs109881631,2
    C,A,H--101315052(+) acccaG/Tagact 1 -- ds50015Minor allele frequency- T:0.00NS EA NA 420
    rs1928251911,2
    C--101315249(+) TTTGGA/GAGGCC 1 -- ds50010--------
    rs1415169581,2
    --101315390(+) GGCTGC/GGACAG 1 -- ds50010--------
    rs1505481431,2
    C--101315442(+) GAGATC/GGCGCC 1 -- ds50010--------
    rs1833334411,2
    --101315504(+) AAAAAA/TAAATA 1 -- ds50010--------
    rs1142546251,2
    C,F--101315506(+) AAAAAA/TATATA 1 -- ds50011Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for DOLK (131707809 - 131710012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DOLK:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv8297n71CNV Loss21882294
    nsv893902CNV Gain21882294


    Human Gene Mutation Database (HGMD): DOLK
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DOLK
    DNA2.0 Custom Variant and Variant Library Synthesis for DOLK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610746   
    OMIM disorders: 610768  
    UniProtKB/Swiss-Prot: DOLK_HUMAN, Q9UPQ8
  • Congenital disorder of glycosylation 1M (CDG1M) [MIM:610768]: A multisystem disorder caused by a defect
    in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of
    glycosylation result in a wide variety of clinical features, such as defects in the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. CDG1M is a very severe disease with death occurring in early life. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for DOLK:    About MalaCards
    congenital disorder of glycosylation, type im    hypotonia    congenital disorder of glycosylation    dilated cardiomyopathy


    DOLK for disorders           About GeneDecksing

    GeneTests: DOLK
    GeneReviews: DOLK

    Export disorders for DOLK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOLK gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with DOLK)
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    1. Human dolichol kinase, a polytopic endoplasmic reticulum membrane protein with a cytoplasmically oriented CTP-binding site. (PubMed id 16923818)1, 2, 3 Shridas P. and Waechter C.J. (2006)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    3. A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy. (PubMed id 17273964)1, 2 Kranz C.... Marquardt T. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. Expression and characterization of a human cDNA that complements the temperature-sensitive defect in dolichol kinase activity in the yeast sec59-1 mutant: the enzymatic phosphorylation of dolichol and diacylglycerol are catalyzed by separate CTP-mediated kinase activities in Saccharomyces cerevisiae. (PubMed id 12213788)1, 2 Fernandez F.... Waechter C.J. (2002)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    8. Autosomal recessive dilated cardiomyopathy due to DOLK mutations results from abnormal dystroglycan O-mannosylation. (PubMed id 22242004)1 Lefeber D.J....Wevers R.A. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22845 HGNC: 23406 AceView: NUP188 Ensembl:ENSG00000175283 euGenes: HUgn22845
    ECgene: DOLK Kegg: 22845 H-InvDB: DOLK

    (According to HUGE)
    About This Section
    HUGE: KIAA1094

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOLK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOLK gene:
    Search GeneIP for patents involving DOLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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