Aliases for DOLK Gene
External Ids for DOLK Gene
Previous HGNC Symbols for DOLK Gene
Previous GeneCards Identifiers for DOLK Gene
The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010]
GeneCards Summary for DOLK Gene
DOLK (Dolichol Kinase) is a Protein Coding gene. Diseases associated with DOLK include Congenital Disorder Of Glycosylation, Type Im and Middle Ear Disease. Among its related pathways are Synthesis of substrates in N-glycan biosythesis and Transport to the Golgi and subsequent modification. GO annotations related to this gene include dolichol kinase activity.
UniProtKB/Swiss-Prot for DOLK Gene
Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors.