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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOK7 Gene

protein-coding   GIFtS: 50
GCID: GC04P003465

Docking Protein 7

(Previous name: chromosome 4 open reading frame 25)
(Previous symbol: C4orf25)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Docking Protein 71 2
C4orf251 2 3 5
Downstream Of Tyrosine Kinase 72 3
CMS1B2 5
Chromosome 4 Open Reading Frame 251
Protein Dok-72

External Ids:    HGNC: 265941   Entrez Gene: 2854892   Ensembl: ENSG000001759207   OMIM: 6102855   UniProtKB: Q18PE13   

Export aliases for DOK7 gene to outside databases

Previous GC identifer: GC04P003434


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOK7 Gene:
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural
activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the
subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation
of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia
autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results
in multiple transcript variants. (provided by RefSeq, Sep 2009)

GeneCards Summary for DOK7 Gene: 
DOK7 (docking protein 7) is a protein-coding gene. Diseases associated with DOK7 include dok7-related fetal akinesia deformation sequence, and myasthenia, limb-girdle, familial. GO annotations related to this gene include protein kinase binding and insulin receptor binding.

UniProtKB/Swiss-Prot: DOK7_HUMAN, Q18PE1
Function: Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular
synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in
myotubes. Induces autophosphorylation of MUSK




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006051.18  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOK7 gene promoter:
         USF1   AML1a   AP-4   Nkx2-5   YY1   E47   CREB   USF-1   Zic3   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DOK7 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOK7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.2

DOK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P003465:  view genomic region     (about GC identifiers)

Start:
3,465,033 bp from pter      End:
3,503,200 bp from pter
Size:
38,168 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOK7_HUMAN, Q18PE1 (See protein sequence)
Recommended Name: Protein Dok-7  
Size: 504 amino acids; 53097 Da
Subunit: Homodimer (By similarity). Forms a heterotetramer composed of 2 DOK7 and 2 MUSK molecules which
facilitates MUSK trans-autophosphorylation on tyrosine residue and activation (By similarity). Interacts (via
IRS-type PTB domain) with MUSK (via cytoplasmic part); requires MUSK phosphorylation
Subcellular location: Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By
similarity). Note=Accumulates at neuromuscular junctions (By similarity)
Sequence caution: Sequence=BAC11367.1; Type=Miscellaneous discrepancy; Note=Contains a poly-A tail in the
5'region;
Secondary accessions: A2A499 A2RRD4 E9PB56 Q6P6A6 Q86XG5 Q8N2J3 Q8NBC1
Alternative splicing: 4 isoforms:  Q18PE1-1   Q18PE1-2   Q18PE1-4   Q18PE1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOK7: NX_Q18PE1

Explore proteomics data for DOK7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q18PE1

  • DOK7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOK7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001158145.1  NP_001243825.1  NP_775931.3  

    ENSEMBL proteins: 
     ENSP00000423614   ENSP00000344432   ENSP00000374304  

    Human Recombinant Protein Products for DOK7: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOK7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0030054cell junction IEA--
    GO:0031594neuromuscular junction IEA--

    DOK7 for ontologies           About GeneDecksing



    DOK7 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q18PE1

    ProtoNet protein and cluster: Q18PE1

    UniProtKB/Swiss-Prot: DOK7_HUMAN, Q18PE1
    Domain: The PH domain mediated binding to phospholipids with phosphoinositol headgroups. Affinity is highest for
    phosphatidyl 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol
    4,5-bisphosphate (By similarity)
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    DOK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK7_HUMAN, Q18PE1
    Function: Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular
    synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in
    myotubes. Induces autophosphorylation of MUSK

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding ----
    GO:0019901protein kinase binding IDA--
    GO:0035091phosphatidylinositol binding IEA--
         
    DOK7 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dok7):
     behavior/neurological  mortality/aging  nervous system  respiratory system 

    DOK7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dok7tm1Yyam for DOK7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOK7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOK7

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOK7 

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    hsa-miR-185*
    SwitchGear 3'UTR luciferase reporter plasmidDOK7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOK7

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for DOK7 (Q18PE13 ENSP000003444324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MUSKO151463, ENSP000003635714I2D: score=1 STRING: ENSP00000363571
    ATG10Q9H0Y03I2D: score=1 
    --Q6FG913I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0007528neuromuscular junction development IEA--
    GO:0043113receptor clustering IEA--
    GO:0061098positive regulation of protein tyrosine kinase activity IDA--

    DOK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOK7

    Search CenterWatch for drugs/clinical trials and news about DOK7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOK7 gene (3 alternative transcripts): 
    NM_001164673.1  NM_001256896.1  NM_173660.4  

    Unigene Clusters for DOK7:

    Docking protein 7
    Hs.122110  [show with all ESTs], Hs.701584  [show with all ESTs]
    Unigene Representative Sequences: NM_173660, AK075037
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511267 ENST00000503688 ENST00000507039(uc003ghe.3) ENST00000340083(uc003ghd.3)
    ENST00000515886(uc003ghf.3) ENST00000513995 ENST00000512714(uc003ghg.1)
    ENST00000389653
    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate DOK7:
    hsa-miR-185*
    SwitchGear 3'UTR luciferase reporter plasmidDOK7 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOK7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOK7

    Additional mRNA sequence: AK075037.1 

    4 DOTS entries:

    DT.95117736  DT.40125001  DT.97819298  DT.121251361 

    22 AceView cDNA sequences:

    AX746744 AK091037 NM_173660 BM929763 CD513121 BU857646 BC062369 BQ787121 
    BC043568 AK075037 BG680641 AK096456 AW189555 BF308079 BQ786851 AW474640 
    AA779697 AI743416 AI376727 AI689331 BM726730 BI910181 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DOK7 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11
    SP1:                          -     -     -                                                               
    SP2:              -     -     -     -     -                                                               
    SP3:                                      -                                                               
    SP4:                                                                                -                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for DOK7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCTCCTG
    DOK7 Expression
    About this image


    See DOK7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOK7

    SOURCE GeneReport for Unigene clusters: Hs.122110 Hs.701584

    UniProtKB/Swiss-Prot: DOK7_HUMAN, Q18PE1
    Tissue specificity: Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and
    heart but not in the liver or spleen (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DOK7 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dok71 , 5 docking protein 71, 5 81.17(n)1
    84.42(a)1
      5 (18.00 cM)5
    2311341  NM_172708.31  NP_766296.11 
     350568135 
    chicken
    (Gallus gallus)
    Aves DOK71 docking protein 7 65.51(n)
    69.72(a)
      422875  XM_420818.3  XP_420818.3 
    lizard
    (Anolis carolinensis)
    Reptilia DOK76
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343236.1(2085095-2110219)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.163032 Transcribed sequences 69.94(n)    BI326636.1 


    ENSEMBL Gene Tree for DOK7 (if available)
    TreeFam Gene Tree for DOK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1390 SNPs in DOK7 are shown (see all 1390)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0687524
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687522 A V mis40--------
    VAR_0687644
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687642 G D mis40--------
    VAR_0687674
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687672 G V mis40--------
    VAR_0687634
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687632 G R mis40--------
    VAR_0687564
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687562 G C mis40--------
    VAR_0687604
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687602 P L mis40--------
    VAR_0687584
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687582 H Q mis40--------
    VAR_0687544
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687542 T M mis40--------
    VAR_0687514
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687512 P T mis40--------
    VAR_0687504
    Myasthenia, limb-girdle, familial (LGM)4--see VAR_0687502 E K mis40--------

    HapMap Linkage Disequilibrium report for DOK7 (3465033 - 3503200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/57 variations for DOK7 (see all 57):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670025CNV Deletion23128226
    esv2726892CNV Deletion23290073
    esv1301117CNV Deletion17803354
    esv2657183CNV Deletion23128226
    esv2726893CNV Deletion23290073
    esv2726890CNV Deletion23290073
    esv2665392CNV Deletion23128226
    esv2726888CNV Deletion23290073
    esv2726898CNV Deletion23290073
    esv2223892CNV Deletion18987734


    Human Gene Mutation Database (HGMD): DOK7

    Locus Specific Mutation Databases (LSDB): DOK7
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DOK7
    DNA2.0 Custom Variant and Variant Library Synthesis for DOK7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610285   
    OMIM disorders: 254300  208150  
    UniProtKB/Swiss-Prot: DOK7_HUMAN, Q18PE1
  • Myasthenia, limb-girdle, familial (LGM) [MIM:254300]: A congenital myasthenic syndrome characterized by a
    typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal
    acetylcholine receptor and acetylcholinesterase function. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 9 diseases for DOK7:    About MalaCards
    dok7-related fetal akinesia deformation sequence    myasthenia, limb-girdle, familial    dok7-related congenital myasthenic syndrome    endplate acetylcholinesterase deficiency
    fetal akinesia deformation sequence    congenital myasthenic syndrome    myasthenia gravis    myopathy
    neuropathy

    2 diseases from the University of Copenhagen DISEASES database for DOK7:
    Myopathy     Neuropathy

    DOK7 for disorders           About GeneDecksing

    GeneTests: DOK7
    GeneReviews: DOK7
    Human Genome Epidemiology (HuGE) Navigator: DOK7 (1 document)

    Export disorders for DOK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOK7 gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with DOK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. (PubMed id 16794080)1, 2, 3 Okada K.... Yamanashi Y. (2006)
    2. The spectrum of mutations that underlie the neuromuscular junction synaptopathy in DOK7 congenital myasthenic syndrome. (PubMed id 22661499)1, 2 Cossins J.... Beeson D. (2012)
    3. The cytoplasmic adaptor protein Dok7 activates the re ceptor tyrosine kinase MuSK via dimerization. (PubMed id 20603078)1, 2 Bergamin E....Hubbard S.R. (2010)
    4. Phenotype genotype analysis in 15 patients presenting a congenital myasthenic syndrome due to mutations in DOK7. (PubMed id 20012313)1, 2 Ben Ammar A....Eymard B. (2010)
    5. Phenotypical spectrum of DOK7 mutations in congenital myasthenic syndromes. (PubMed id 17439981)1, 2 Muller J.S....Lochmuller H. (2007)
    6. Dok-7 mutations underlie a neuromuscular junction synaptopathy. (PubMed id 16917026)1, 2 Beeson D.... Yamanashi Y. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. DOK7 limb-girdle myasthenic syndrome mimicking congeni tal muscular dystrophy. (PubMed id 22884442)1 Mahjneh I....Abicht A. (2013)
    10. DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker. (PubMed id 23054610)1 Heyn H....Esteller M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 285489 HGNC: 26594 AceView: FLJ33718 Ensembl:ENSG00000175920 euGenes: HUgn285489
    ECgene: DOK7 H-InvDB: DOK7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOK7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOK7 gene:
    Search GeneIP for patents involving DOK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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