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DOK6 Gene

protein-coding   GIFtS: 53
GCID: GC18P067068

Docking Protein 6

(Previous name: docking protein 5-like)
(Previous symbol: DOK5L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Docking Protein 61 2
DOK5L1 2 3
Downstream Of Tyrosine Kinase 62 3
Docking Protein 5-Like1
HsT32262

External Ids:    HGNC: 283011   Entrez Gene: 2201642   Ensembl: ENSG000002060527   OMIM: 6114025   UniProtKB: Q6PKX43   

Export aliases for DOK6 gene to outside databases

Previous GC identifers: GC18P065220 GC18P063951


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOK6 Gene:
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET
(MIM 164761) signaling cascade (Crowder et al., 2004 (PubMed 15286081)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DOK6 Gene:
DOK6 (docking protein 6) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a
role in brain development and/or maintenance




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010966.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOK6 gene promoter:
         Sp1   CUTL1   CBF-C   GATA-2   CBF-A   CBF-B   CP1C   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOK6 promoter sequence
   Search Chromatin IP Primers for DOK6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOK6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q22.2   Ensembl cytogenetic band:  18q22.2   HGNC cytogenetic band: 18q22.2

DOK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK6 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P067068:  view genomic region     (about GC identifiers)

Start:
67,068,284 bp from pter      End:
67,516,323 bp from pter
Size:
448,040 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4 (See protein sequence)
Recommended Name: Docking protein 6  
Size: 331 amino acids; 38318 Da
Subunit: Interacts via its PTB domain with phosphorylated RET
Sequence caution: Sequence=BAB71577.1; Type=Erroneous initiation;
Secondary accessions: A6NNG3 Q4V9S3 Q8WUZ8 Q96HI2 Q96LU2

Explore the universe of human proteins at neXtProt for DOK6: NX_Q6PKX4

Explore proteomics data for DOK6 at MOPED

Post-translational modifications: 

  • On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOK6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689934.2  
    ENSEMBL proteins: 
     ENSP00000372160   ENSP00000462984  

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    Cloud-Clone Corp. Proteins for DOK6

     
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    Search eBioscience for ELISAs for DOK6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q6PKX4

    ProtoNet protein and cluster: Q6PKX4

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4
    Domain: PTB domain mediates receptor interaction (By similarity)
    Similarity: Belongs to the DOK family. Type B subfamily
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    Find genes that share domains with DOK6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK6_HUMAN, Q6PKX4
    Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
    for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a
    role in brain development and/or maintenance

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI16273093
         
    Find genes that share ontologies with DOK6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DOK6:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOK6
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    miRNA
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    miRTarBase miRNAs that target DOK6:
    hsa-mir-1 (MIRT023914), hsa-mir-335-5p (MIRT018286)

    Block miRNA regulation of human, mouse, rat DOK6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOK6 (see all 91):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-106a hsa-miR-4272 hsa-miR-219-5p hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidDOK6 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    eBioscience FlowRNA Probe Sets ( VA1-13576) for DOK6 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOK6 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling events regulated by Ret tyrosine kinase
    Signaling events regulated by Ret tyrosine kinase


    1 BioSystems Pathway for DOK6
        Signaling events regulated by Ret tyrosine kinase


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOK6
    Interactions:

        Search GeneGlobe Interaction Network for DOK6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for DOK6 (Q6PKX41, 2, 3 ENSP000003721604) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3MINT-74519 I2D: score=2 
    EGFRP005331, 2, 3, ENSP000002754934EBI-2880244,EBI-297353 MINT-74517 MINT-74518 I2D: score=2 STRING: ENSP00000275493
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    RETP079493, ENSP000003479424I2D: score=2 STRING: ENSP00000347942
    GDNFENSP000003171454STRING: ENSP00000317145
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOK6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DOK6 gene: 
    NM_152721.5  

    Unigene Cluster for DOK6:

    Docking protein 6
    Hs.278285  [show with all ESTs]
    Unigene Representative Sequence: NM_152721
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382713(uc002lkl.3) ENST00000582172 ENST00000584435 ENST00000582992
    ENST00000577609
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DOK6 (see all 91):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-106a hsa-miR-4272 hsa-miR-219-5p hsa-miR-374a hsa-miR-3653 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidDOK6 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOK6
      QuantiTect SYBR Green Assays in human, mouse, rat DOK6
      QuantiFast Probe-based Assays in human, mouse, rat DOK6
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-13576) for DOK6 

    Additional mRNA sequence: 

    AK057795.1 AL512695.1 AY599248.1 BC008583.1 BC019045.2 BC096744.1 

    6 DOTS entries:

    DT.204190  DT.436966  DT.100737921  DT.65287172  DT.100694926  DT.121085081 

    Selected AceView cDNA sequences (see all 31):

    BX280184 CD672764 BG190235 AI022989 BE552411 AK057795 BC019045 BC008583 
    BX493849 NM_152721 AY599248 AA442870 BX493291 BF530452 BM451354 BX357639 
    BI546276 BF057291 BF115572 AW051318 D81422 AA429780 AW294913 BG572298 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOK6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACACACA
    DOK6 Expression
    About this image

    DOK6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOK6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.278285

    UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4
    Tissue specificity: Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression
    in kidney, spinal cord and testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DOK6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dok61 , 5 docking protein 61, 5 91.84(n)1
    99.7(a)1
      18 (59.05 cM)5
    6232791  NM_001039173.11  NP_001034262.11 
     893010825 
    chicken
    (Gallus gallus)
    Aves DOK61 docking protein 6 84.59(n)
    94.86(a)
      421025  XM_419111.3  XP_419111.2 
    lizard
    (Anolis carolinensis)
    Reptilia DOK66
    docking protein 6
    84(a)
    1 ↔ 1
    4(46764646-46916328)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dok61 docking protein 6 81.35(n)
    94.76(a)
      100494237  XM_002939618.2  XP_002939664.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dok61 docking protein 6 75.16(n)
    84.52(a)
      795289  NM_001089439.1  NP_001082908.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dok6
    Downstream of kinase
    10(a)
    1 → many
    X(7218251-7222839)


    ENSEMBL Gene Tree for DOK6 (if available)
    TreeFam Gene Tree for DOK6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOK6 gene
    DOK12  DOK42  DOK32  DOK22  DOK52  
    3 SIMAP similar genes for DOK6 using alignment to 2 protein entries:     DOK6_HUMAN (see all proteins):
    DOK4    DOK5    FRS2

    Find genes that share paralogs with DOK6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOK6 (see all 9682)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906947331,2
    Cuntested167254568(+) TTAGCA/C/GCAACA 1 -- int10--------
    rs106290641,2
    C--63981395(+) AAAAA-/A/AA  
            
    GAAAG
    1 -- int1 trp30--------
    rs556546601,2
    C--63990600(+) AAAAA-/A/A   
      A
    /AAAA
    GGACA
    1 -- int11NA 2
    rs106594441,2
    C--64063423(+) gtgtg-/TAtatat 1 -- int10--------
    rs556706001,2
    C--64194280(+) GATCA-/GACTCAA 1 -- int11Minor allele frequency- GA:0.00NA 2
    rs80896711,2
    C,F--66920834(+) AACATG/AAATGT 1 -- us2k1 tfbs35Minor allele frequency- A:0.20CSA WA NA EA 362
    rs80898881,2
    C,F,A,H--67066549(+) TGCAGC/TGTATG 1 -- us2k118Minor allele frequency- T:0.23NS EA NA CSA WA 2226
    rs1462691841,2
    C--67066603(+) TTAGA-/GGAAAG 1 -- us2k10--------
    rs1915758941,2
    C--67066654(+) AGAAGA/GTCAGA 1 -- us2k10--------
    rs570699631,2
    C--67066817(+) TATTT-/AAAAAA 1 -- us2k12Minor allele frequency- A:0.25NA CSA 4

    HapMap Linkage Disequilibrium report for DOK6 (67068284 - 67318284 bp, first 250kb of DOK6)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DOK6 (see all 59):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664077CNV Deletion23128226
    esv2666112CNV Deletion23128226
    esv1008327CNV Deletion20482838
    esv2717298CNV Deletion23290073
    esv2861CNV Deletion18987735
    esv2717295CNV Deletion23290073
    esv2675546CNV Deletion23128226
    esv2717294CNV Deletion23290073
    esv2717290CNV Deletion23290073
    esv2421592CNV Deletion20811451

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOK6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611402    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DOK6:
    Beckwith-Wiedemann syndrome

    Find genes that share disorders with DOK6           About GenesLikeMe

    Genetic Association Database (GAD): DOK6
    Human Genome Epidemiology (HuGE) Navigator: DOK6 (2 documents)

    Export disorders for DOK6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOK6 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with DOK6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. (PubMed id 15286081)1, 2, 3 Crowder R.J.... Milbrandt J. (J. Biol. Chem. 2004)
    2. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. (PubMed id 20548944)1, 4 Hsu Y.H....Kiel D.P. (PLoS Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    7. Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells. (PubMed id 20210798)1 Kurotsuchi A....Takahashi M. (Cancer Sci. 2010)
    8. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)4 Soranzo N....Gieger C. (Nat. Genet. 2009)
    9. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 220164 HGNC: 28301 AceView: DOK5L Ensembl:ENSG00000206052 euGenes: HUgn220164
    ECgene: DOK6 H-InvDB: DOK6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOK6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOK6 gene:
    Search GeneIP for patents involving DOK6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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