DOK6 Gene
protein-coding GIFtS : 54
GCID: GC18 P067068
docking protein 6 (Previous name: docking protein 5-like ) (Previous symbol: DOK5L )
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Aliasesfor DOK6 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Docking Protein 6 1 2 DOK5L1 2 3 HsT32261 2 Downstream Of Tyrosine Kinase 62 3 MGC207851 Docking Protein 5-Like1
Export aliases for DOK6 gene to outside databases Previous GC identifers: GC18P065220 GC18P063951
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Summariesfor DOK6 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DOK6 : DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 (PubMed 15286081)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4 Function : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for theassembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance
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Genomic Viewsfor DOK6 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000018.9 NC_018929.1 NT_025028.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DOK6 gene promoter: Sp1 CUTL1 CBF-C GATA-2 CBF-A CBF-B CP1C CP1A NF-Y CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for DOK6 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DOK6
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 18q22.2 Ensembl cytogenetic band: 18q22.2 HGNC cytogenetic band: 18q22.2 DOK6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18P067068: view genomic region
(about GC identifiers )
Start:
67,068,284 bp from pter
End:
67,516,323 bp from pter
Size:
448,040 bases
Orientation:
plus strand
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Proteinsfor DOK6 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4 (See
protein sequence )Recommended Name: Docking protein 6 Size : 331 amino acids; 38318 Da
Subunit : Interacts via its PTB domain with phosphorylated RET
Sequence caution : Sequence=BAB71577.1; Type=Erroneous initiation;
Secondary accessions : A6NNG3 Q4V9S3 Q8WUZ8 Q96HI2 Q96LU2Explore the universe of human proteins at neXtProt for DOK6: NX_Q6PKX4 Post-translational modifications:
On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6PKX4 DOK6 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689934.2 ENSEMBL proteins: ENSP00000372160 ENSP00000462984 Human Recombinant Protein Products: DOK6 Antibody Products: Assay Products for DOK6:
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Protein
Domains / Familiesfor DOK6 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DOK6 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6PKX4 ProtoNet protein and cluster: Q6PKX4
1 Blocks protein family : IPB001849 Pleckstrin-like UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4 Domain : PTB domain mediates receptor interaction (By similarity)Similarity : Belongs to the DOK family. Type B subfamilySimilarity : Contains 1 IRS-type PTB domainSimilarity : Contains 1 PH domain
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Functionfor DOK6 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4 Function : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for theassembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DOK6 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DOK6OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DOK6 (NM_152721 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOK6 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DOK6
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK6
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005158 insulin receptor binding
IEA -- GO:0005543 phospholipid binding
IEA --
DOK6 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for DOK6 :
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Pathways & Interactionsfor DOK6 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Signaling events regulated by Ret tyrosine kinase
1 BioSystems Pathway for DOK6 Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOK6 STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)5/7 Interacting proteins for DOK6 (Q6PKX4 2 , 3 ENSP00000372160 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 7 )About this table
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Drugs & Compoundsfor DOK6 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DOK6 Search CenterWatch for drugs/clinical trials and news about DOK6
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Transcriptsfor DOK6 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DOK6 gene: NM_152721.5 Unigene Cluster for DOK6:
Docking protein 6 Hs.278285 [show with all ESTs ] Unigene Representative Sequence: NM_152721 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000382713 (uc002lkl.3 ) ENST00000582172 ENST00000584435 ENST00000582992 ENST00000577609 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DOK6 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DOK6OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DOK6 (NM_152721 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOK6 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DOK6
Additional cDNA sequence: AK057795.1 AL512695.1 AY599248.1 BC008583.1 BC019045.2 BC096744.1
6 DOTS entries : DT.204190 DT.436966
DT.100737921 DT.65287172 DT.100694926 DT.121085081 24/31 AceView cDNA sequences (see all 31 ):
AI022989 CD672764 BG190235 BX280184 AK057795 BX357639 BI546276 AA442870 BF115572 AY599248 BF057291 BX493291 BC019045 NM_152721 BX493849 BE552411 BF530452 BC008583 BM451354 AW051318 AW294913 BG471399 BG572298 AA429780 GeneLoc Exon Structure
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Expression for DOK6 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DOK6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTCACACACA
About this image DOK6 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Primitive gut tube-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DOK6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DOK6 SOURCE GeneReport for Unigene cluster: Hs.278285 UniProtKB/Swiss-Prot: DOK6_HUMAN, Q6PKX4 Tissue specificity : Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression inkidney, spinal cord and testis SABiosciences Custom PCR Arrays for DOK6 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DOK6Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DOK6 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DOK6 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DOK6 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK6
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Orthologsfor DOK6 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for DOK6 gene from 3/9 species (see all 9 ) About this table
ENSEMBL Gene Tree for DOK6 (if available)TreeFam Gene Tree for DOK6 (if available)
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Paralogsfor DOK6 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DOK6 gene DOK4 2 DOK5 2 3 SIMAP similar genes for DOK6 using alignment to 2 protein entries: DOK6_HUMAN (see all proteins ):DOK4 DOK5 FRS2
DOK6 for paralogs About GeneDecksing
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Genomic Variantsfor DOK6 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 18 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DOK6 (67068284 - 67318284 bp, first 250kb of DOK6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 24 variations for DOK6 15/16 CNVs (see all 16 ): 37892 67398 50040 88920 50042 50041 43658 50038 10537 50043 50039 53616 39221 7188 1298 8 Indels : 11974 77929 45678 88922 77928 88921 26098 77930
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DOK6
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Disorders
/ Diseasesfor DOK6 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DOK6 for disorders About GeneDecksing
OMIM gene information: 611402
OMIM disorders : --3 diseases for DOK6 : About MalaCards beckwith-wiedemann syndrome osteoporosis neuroblastoma 1 disease from the University of Copenhagen DISEASES database for DOK6 :Beckwith-Wiedemann syndrome Human Genome Epidemiology (HuGE) Navigator: DOK6 (2 documents) Export disorders for DOK6 gene to outside databases
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Publicationsfor DOK6 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DOK6 gene integrated from 9 sources : (articles sorted by number of sources associating them with DOK6) Utopia : connect your pdf to the dynamic world of online information
Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. (PubMed id 15286081) 1 , 2 , 3 Crowder R.J.... Milbrandt J. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) An integration of genome-wide association study and g ene expression profiling to prioritize the discovery of novel susceptibility Lo ci for osteoporosis-related traits. (PubMed id 20548944) 1 Hsu Y.H....Kiel D.P. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells. (PubMed id 20210798) 1 Kurotsuchi A....Takahashi M. (2010) DNA sequence and analysis of human chromosome 18. (PubMed id 16177791) 2 Nusbaum C.... Lander E.S. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DOK6 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DOK6 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DOK6 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DOK6 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DOK6 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DOK6 gene: Search GeneIP for patents involving DOK6 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DOK6 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DOK6 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DOK6 OriGene Protein Over-expression Lysate for DOK6 Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for DOK6 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DOK6 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DOK6 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DOK6 OriGene Custom Protein Services for DOK6 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOK6 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DOK6 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DOK6 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DOK6 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DOK6 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DOK6
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DOK6 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK6
ThermoFisher Antibodies for DOK6
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DOK6
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Aliases for DOK6
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Disorders / Diseases for DOK6
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Expression for DOK6
Function for DOK6
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