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Aliases for DOK6 Gene

Aliases for DOK6 Gene

  • Docking Protein 6 2 3 5
  • Downstream Of Tyrosine Kinase 6 3 4
  • DOK5L 3 4
  • Docking Protein 5-Like 2
  • HsT3226 3

External Ids for DOK6 Gene

Previous HGNC Symbols for DOK6 Gene

  • DOK5L

Previous GeneCards Identifiers for DOK6 Gene

  • GC18P065220
  • GC18P067068
  • GC18P063951

Summaries for DOK6 Gene

Entrez Gene Summary for DOK6 Gene

  • DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DOK6 Gene

DOK6 (Docking Protein 6) is a Protein Coding gene. Among its related pathways are Signaling events regulated by Ret tyrosine kinase. GO annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK6 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK6 Gene

Genomics for DOK6 Gene

Regulatory Elements for DOK6 Gene

Enhancers for DOK6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DOK6 on UCSC Golden Path with GeneCards custom track

Promoters for DOK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOK6 on UCSC Golden Path with GeneCards custom track

Genomic Location for DOK6 Gene

69,401,048 bp from pter
69,849,087 bp from pter
448,040 bases
Plus strand

Genomic View for DOK6 Gene

Genes around DOK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK6 Gene

Proteins for DOK6 Gene

  • Protein details for DOK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Docking protein 6
    Protein Accession:
    Secondary Accessions:
    • A6NNG3
    • Q4V9S3
    • Q8WUZ8
    • Q96HI2
    • Q96LU2

    Protein attributes for DOK6 Gene

    331 amino acids
    Molecular mass:
    38318 Da
    Quaternary structure:
    • Interacts via its PTB domain with phosphorylated RET.
    • Sequence=BAB71577.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DOK6 Gene

Proteomics data for DOK6 Gene at MOPED

Post-translational modifications for DOK6 Gene

  • On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOK6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DOK6 Gene

Domains & Families for DOK6 Gene

Gene Families for DOK6 Gene

Protein Domains for DOK6 Gene


Suggested Antigen Peptide Sequences for DOK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type B subfamily.
  • PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
  • Belongs to the DOK family. Type B subfamily.
genes like me logo Genes that share domains with DOK6: view

Function for DOK6 Gene

Molecular function for DOK6 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.

Gene Ontology (GO) - Molecular Function for DOK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IEA --
genes like me logo Genes that share ontologies with DOK6: view
genes like me logo Genes that share phenotypes with DOK6: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOK6 Gene

Localization for DOK6 Gene

Subcellular locations from

Jensen Localization Image for DOK6 Gene COMPARTMENTS Subcellular localization image for DOK6 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DOK6 Gene

Pathways & Interactions for DOK6 Gene

genes like me logo Genes that share pathways with DOK6: view

Pathways by source for DOK6 Gene

1 BioSystems pathway for DOK6 Gene

SIGNOR curated interactions for DOK6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DOK6 Gene


Drugs & Compounds for DOK6 Gene

No Compound Related Data Available

Transcripts for DOK6 Gene

Unigene Clusters for DOK6 Gene

Docking protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOK6 Gene

No ASD Table

Relevant External Links for DOK6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOK6 Gene

mRNA expression in normal human tissues for DOK6 Gene

mRNA differential expression in normal tissues according to GTEx for DOK6 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6).

Protein differential expression in normal tissues from HIPED for DOK6 Gene

This gene is overexpressed in Ovary (42.4) and Peripheral blood mononuclear cells (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DOK6 Gene

SOURCE GeneReport for Unigene cluster for DOK6 Gene Hs.278285

mRNA Expression by UniProt/SwissProt for DOK6 Gene

Tissue specificity: Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.
genes like me logo Genes that share expression patterns with DOK6: view

Protein tissue co-expression partners for DOK6 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DOK6 Gene

Orthologs for DOK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DOK6 35
  • 90.63 (n)
  • 98.19 (a)
DOK6 36
  • 98 (a)
(Canis familiaris)
Mammalia DOK6 35
  • 94.28 (n)
  • 99.35 (a)
DOK6 36
  • 98 (a)
(Mus musculus)
Mammalia Dok6 35
  • 91.84 (n)
  • 99.7 (a)
Dok6 16
Dok6 36
  • 100 (a)
(Pan troglodytes)
Mammalia DOK6 35
  • 99.3 (n)
  • 100 (a)
DOK6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dok6 35
  • 91.94 (n)
  • 99.7 (a)
(Monodelphis domestica)
Mammalia DOK6 36
  • 90 (a)
(Gallus gallus)
Aves DOK6 35
  • 84.59 (n)
  • 94.86 (a)
DOK6 36
  • 95 (a)
(Anolis carolinensis)
Reptilia DOK6 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dok6 35
  • 81.35 (n)
  • 94.76 (a)
(Danio rerio)
Actinopterygii dok6 35
  • 75.16 (n)
  • 84.52 (a)
dok6 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dok 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 36
  • 16 (a)
Species with no ortholog for DOK6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK6 Gene

Gene Tree for DOK6 (if available)
Gene Tree for DOK6 (if available)

Paralogs for DOK6 Gene

Paralogs for DOK6 Gene

(3) SIMAP similar genes for DOK6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DOK6: view

Variants for DOK6 Gene

Sequence variations from dbSNP and Humsavar for DOK6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs3729 -- 69,660,028(+) TTTGG(A/G)GGTGT intron-variant
rs3731 -- 69,660,073(+) CTGCA(A/C)CCTCT intron-variant
rs187160 -- 69,418,006(+) gtagg(C/T)tttct intron-variant
rs1545095 -- 69,797,305(-) TATCC(A/G)ACTAC intron-variant
rs1545247 -- 69,519,290(-) TAAAT(C/T)ACTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOK6 Gene

Variant ID Type Subtype PubMed ID
esv32736 CNV Gain+Loss 17666407
nsv909851 CNV Loss 21882294
esv2717289 CNV Deletion 23290073
nsv523105 CNV Gain 19592680
esv2664077 CNV Deletion 23128226
esv2717290 CNV Deletion 23290073
dgv503e201 CNV Deletion 23290073
esv2668347 CNV Deletion 23128226
esv26936 CNV Loss 19812545
nsv515792 CNV Loss 19592680
nsv437829 CNV Loss 16327808
nsv909852 CNV Loss 21882294
nsv909853 CNV Gain 21882294
esv2717294 CNV Deletion 23290073
esv268666 CNV Insertion 20981092
esv1507792 CNV Insertion 17803354
nsv909854 CNV Loss 21882294
esv2673472 CNV Deletion 23128226
esv2717295 CNV Deletion 23290073
dgv3460n71 CNV Loss 21882294
nsv528494 CNV Loss 19592680
dgv3461n71 CNV Gain 21882294
nsv909861 CNV Loss 21882294
nsv517162 CNV Loss 19592680
esv2421592 CNV Deletion 20811451
nsv442449 CNV CNV 18776908
esv2861 CNV Deletion 18987735
esv2658803 CNV Deletion 23128226
esv2717297 CNV Deletion 23290073
nsv828295 CNV Loss 20364138
nsv458276 CNV Loss 19166990
dgv390n27 CNV Loss 19166990
nsv817807 CNV Loss 17921354
esv24037 CNV Loss 19812545
nsv514885 CNV Loss 21397061
nsv909862 CNV Gain 21882294
esv2717298 CNV Deletion 23290073
nsv510747 CNV Loss 20534489
esv2717299 CNV Deletion 23290073
nsv510464 CNV Loss 20534489
esv2268046 CNV Deletion 18987734
esv1008327 CNV Deletion 20482838
esv1633222 CNV Deletion 17803354
nsv131554 CNV Loss 16902084
nsv833685 CNV Loss 17160897
esv2717300 CNV Deletion 23290073
nsv909863 CNV Loss 21882294
nsv909864 CNV Gain 21882294
nsv909865 CNV Loss 21882294
nsv520983 CNV Loss 19592680
nsv510748 CNV Loss 20534489
esv2666112 CNV Deletion 23128226
esv2717301 CNV Deletion 23290073
esv1558164 CNV Deletion 17803354
esv2717302 CNV Deletion 23290073
esv2717303 CNV Deletion 23290073
esv2675546 CNV Deletion 23128226
nsv523563 CNV Loss 19592680
nsv909866 CNV Loss 21882294

Variation tolerance for DOK6 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DOK6 Gene

Disorders for DOK6 Gene

Relevant External Links for DOK6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DOK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK6 Gene

Publications for DOK6 Gene

  1. Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. (PMID: 15286081) Crowder R.J. … Milbrandt J. (J. Biol. Chem. 2004) 2 3 4 67
  2. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells. (PMID: 20210798) Kurotsuchi A. … Takahashi M. (Cancer Sci. 2010) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for DOK6 Gene

Sources for DOK6 Gene