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Aliases for DOK6 Gene

Aliases for DOK6 Gene

  • Docking Protein 6 2 3 5
  • Downstream Of Tyrosine Kinase 6 3 4
  • DOK5L 3 4
  • Docking Protein 5-Like 2
  • HsT3226 3

External Ids for DOK6 Gene

Previous HGNC Symbols for DOK6 Gene

  • DOK5L

Previous GeneCards Identifiers for DOK6 Gene

  • GC18P065220
  • GC18P067068
  • GC18P063951

Summaries for DOK6 Gene

Entrez Gene Summary for DOK6 Gene

  • DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DOK6 Gene

DOK6 (Docking Protein 6) is a Protein Coding gene. Among its related pathways are Developmental Biology and RET signaling. GO annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK5.

UniProtKB/Swiss-Prot for DOK6 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK6 Gene

Genomics for DOK6 Gene

Regulatory Elements for DOK6 Gene

Enhancers for DOK6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18G069356 0.9 dbSUPER 12.2 -42.5 -42527 3.6 ELF3 TBP FOXA2 ATF1 MLX ARID4B RAD21 ZSCAN9 RARA GATA4 DOK6 GC18P069340 ENSG00000278532
GH18G069349 0.9 dbSUPER 11.3 -50.7 -50720 1.1 ELF3 FOXA2 ATF1 ARID4B RARA GATA4 CREM MIXL1 THAP11 CEBPB DOK6 GC18P069340 ENSG00000278532
GH18G069403 0.6 FANTOM5 12 +1.1 1070 0.4 ZNF202 MXI1 RNF2 SUZ12 CBX2 ZNF48 CTBP2 EZH2 DOK6 GC18M069396
GH18G069894 1.4 Ensembl ENCODE dbSUPER 5.1 +495.7 495746 4.3 HDGF PKNOX1 TBL1XR1 BMI1 YBX1 YY1 RELB IKZF2 CREM CBFB CD226 DOK6 GC18M069851
GH18G069878 0.5 ENCODE 5.6 +478.2 478192 1.6 SMARCA4 GLIS1 ZNF512 MAX POU5F1 CD226 DOK6 GC18M069851
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOK6 on UCSC Golden Path with GeneCards custom track

Promoters for DOK6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000104752 -248 1201 ELF3 FOXA2 SIN3A ARID4B DMAP1 DNMT3B ZNF48 RAD21 YY1 GATA4

Genomic Location for DOK6 Gene

Chromosome:
18
Start:
69,401,048 bp from pter
End:
69,849,087 bp from pter
Size:
448,040 bases
Orientation:
Plus strand

Genomic View for DOK6 Gene

Genes around DOK6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK6 Gene

Proteins for DOK6 Gene

  • Protein details for DOK6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PKX4-DOK6_HUMAN
    Recommended name:
    Docking protein 6
    Protein Accession:
    Q6PKX4
    Secondary Accessions:
    • A6NNG3
    • Q4V9S3
    • Q8WUZ8
    • Q96HI2
    • Q96LU2

    Protein attributes for DOK6 Gene

    Size:
    331 amino acids
    Molecular mass:
    38318 Da
    Quaternary structure:
    • Interacts via its PTB domain with phosphorylated RET.
    SequenceCaution:
    • Sequence=BAB71577.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DOK6 Gene

Post-translational modifications for DOK6 Gene

  • On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOK6 Gene

No data available for DME Specific Peptides for DOK6 Gene

Domains & Families for DOK6 Gene

Gene Families for DOK6 Gene

Protein Domains for DOK6 Gene

Suggested Antigen Peptide Sequences for DOK6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PKX4

UniProtKB/Swiss-Prot:

DOK6_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type B subfamily.
Domain:
  • PTB domain mediates receptor interaction.
Family:
  • Belongs to the DOK family. Type B subfamily.
genes like me logo Genes that share domains with DOK6: view

Function for DOK6 Gene

Molecular function for DOK6 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.

Gene Ontology (GO) - Molecular Function for DOK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with DOK6: view
genes like me logo Genes that share phenotypes with DOK6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOK6 Gene

Localization for DOK6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOK6 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DOK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOK6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOK6 Gene

Pathways & Interactions for DOK6 Gene

genes like me logo Genes that share pathways with DOK6: view

Pathways by source for DOK6 Gene

1 BioSystems pathway for DOK6 Gene
3 Reactome pathways for DOK6 Gene

SIGNOR curated interactions for DOK6 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DOK6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with DOK6: view

Drugs & Compounds for DOK6 Gene

No Compound Related Data Available

Transcripts for DOK6 Gene

Unigene Clusters for DOK6 Gene

Docking protein 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOK6 Gene

No ASD Table

Relevant External Links for DOK6 Gene

GeneLoc Exon Structure for
DOK6
ECgene alternative splicing isoforms for
DOK6

Expression for DOK6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOK6 Gene

mRNA differential expression in normal tissues according to GTEx for DOK6 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.6).

Protein differential expression in normal tissues from HIPED for DOK6 Gene

This gene is overexpressed in Ovary (42.4) and Peripheral blood mononuclear cells (26.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DOK6 Gene



Protein tissue co-expression partners for DOK6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DOK6 Gene:

DOK6

SOURCE GeneReport for Unigene cluster for DOK6 Gene:

Hs.278285

mRNA Expression by UniProt/SwissProt for DOK6 Gene:

Q6PKX4-DOK6_HUMAN
Tissue specificity: Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.

Evidence on tissue expression from TISSUES for DOK6 Gene

  • Nervous system(4.5)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with DOK6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOK6 Gene

Orthologs for DOK6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK6 34 35
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia DOK6 34 35
  • 94.28 (n)
rat
(Rattus norvegicus)
Mammalia Dok6 34
  • 91.94 (n)
mouse
(Mus musculus)
Mammalia Dok6 34 16 35
  • 91.84 (n)
cow
(Bos Taurus)
Mammalia DOK6 34 35
  • 90.63 (n)
oppossum
(Monodelphis domestica)
Mammalia DOK6 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK6 34 35
  • 84.59 (n)
lizard
(Anolis carolinensis)
Reptilia DOK6 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dok6 34
  • 81.35 (n)
zebrafish
(Danio rerio)
Actinopterygii dok6 34 35
  • 75.16 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dok 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 35
  • 16 (a)
OneToMany
Species where no ortholog for DOK6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK6 Gene

ENSEMBL:
Gene Tree for DOK6 (if available)
TreeFam:
Gene Tree for DOK6 (if available)

Paralogs for DOK6 Gene

Paralogs for DOK6 Gene

(3) SIMAP similar genes for DOK6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DOK6: view

Variants for DOK6 Gene

Sequence variations from dbSNP and Humsavar for DOK6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000000181 -- 69,684,720(+) AGACT(A/G)GAATG intron-variant
rs1000003496 -- 69,421,599(+) GATTT(C/G)ATTTG intron-variant
rs1000004317 -- 69,417,253(+) CCCAC(C/G/T)ATTCT intron-variant
rs1000005556 -- 69,691,097(+) GGAGA(A/C)TCACT intron-variant
rs1000011133 -- 69,541,676(+) CCATG(A/C)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOK6 Gene

Variant ID Type Subtype PubMed ID
dgv133n111 CNV deletion 26073780
dgv35e198 CNV loss 23635498
dgv390n27 CNV loss 19166990
dgv462e201 CNV deletion 23290073
dgv6047n54 CNV loss 21841781
dgv6048n54 CNV loss 21841781
dgv6049n54 CNV loss 21841781
dgv6050n54 CNV loss 21841781
dgv6051n54 CNV loss 21841781
dgv6052n54 CNV loss 21841781
dgv6053n54 CNV loss 21841781
dgv6054n54 CNV loss 21841781
dgv6055n54 CNV loss 21841781
dgv999e212 CNV loss 25503493
esv1008327 CNV deletion 20482838
esv1507792 CNV insertion 17803354
esv1558164 CNV deletion 17803354
esv1633222 CNV deletion 17803354
esv2268046 CNV deletion 18987734
esv24037 CNV loss 19812545
esv2421592 CNV deletion 20811451
esv2656079 CNV loss 23635498
esv2658803 CNV deletion 23128226
esv2664077 CNV deletion 23128226
esv2666112 CNV deletion 23128226
esv2668347 CNV deletion 23128226
esv2673472 CNV deletion 23128226
esv2675546 CNV deletion 23128226
esv26936 CNV loss 19812545
esv2717289 CNV deletion 23290073
esv2717290 CNV deletion 23290073
esv2717294 CNV deletion 23290073
esv2717295 CNV deletion 23290073
esv2717297 CNV deletion 23290073
esv2717298 CNV deletion 23290073
esv2717299 CNV deletion 23290073
esv2717300 CNV deletion 23290073
esv2717301 CNV deletion 23290073
esv2717302 CNV deletion 23290073
esv2717303 CNV deletion 23290073
esv2762688 CNV loss 21179565
esv2861 CNV loss 18987735
esv32736 CNV gain+loss 17666407
esv3304388 CNV mobile element insertion 20981092
esv3355775 CNV insertion 20981092
esv3390195 CNV insertion 20981092
esv3398077 CNV insertion 20981092
esv3555590 CNV deletion 23714750
esv3555591 CNV deletion 23714750
esv3583134 CNV loss 25503493
esv3642964 CNV loss 21293372
esv3642965 CNV loss 21293372
esv3642966 CNV loss 21293372
esv3642968 CNV loss 21293372
esv3642969 CNV loss 21293372
esv3642970 CNV loss 21293372
esv3642973 CNV loss 21293372
esv3642975 CNV loss 21293372
esv3642976 CNV loss 21293372
esv3893134 CNV loss 25118596
nsv1058291 CNV loss 25217958
nsv1072275 CNV deletion 25765185
nsv1111536 CNV deletion 24896259
nsv1123190 CNV deletion 24896259
nsv1135516 CNV deletion 24896259
nsv1153509 CNV duplication 26484159
nsv131554 CNV deletion 16902084
nsv437829 CNV loss 16327808
nsv442449 CNV loss 18776908
nsv458276 CNV loss 19166990
nsv472211 CNV novel sequence insertion 20440878
nsv474787 CNV novel sequence insertion 20440878
nsv510464 OTHER sequence alteration 20534489
nsv510747 CNV deletion 20534489
nsv510748 CNV deletion 20534489
nsv514885 CNV loss 21397061
nsv515792 CNV loss 19592680
nsv517162 CNV loss 19592680
nsv520983 CNV loss 19592680
nsv523105 CNV gain 19592680
nsv523563 CNV loss 19592680
nsv528494 CNV loss 19592680
nsv577507 CNV loss 21841781
nsv577545 CNV loss 21841781
nsv817807 CNV loss 17921354
nsv828295 CNV loss 20364138
nsv833685 CNV loss 17160897

Variation tolerance for DOK6 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK6 Gene

Disorders for DOK6 Gene

Relevant External Links for DOK6

Genetic Association Database (GAD)
DOK6
Human Genome Epidemiology (HuGE) Navigator
DOK6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK6

No disorders were found for DOK6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK6 Gene

Publications for DOK6 Gene

  1. Dok-6, a novel p62 Dok family member, promotes Ret-mediated neurite outgrowth. (PMID: 15286081) Crowder R.J. … Milbrandt J. (J. Biol. Chem. 2004) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. (PMID: 20548944) Hsu Y.H. … Kiel D.P. (PLoS Genet. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DOK6 Gene

Sources for DOK6 Gene

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