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DOK5 Gene

protein-coding   GIFtS: 56
GCID: GC20P053092

Docking Protein 5

(Previous name: chromosome 20 open reading frame 180)
(Previous symbol: C20orf180)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Docking Protein 51 2     IRS-62 3
C20orf1801 2 3     IRS62 3
Downstream Of Tyrosine Kinase 52 3     Chromosome 20 Open Reading Frame 1801
Insulin Receptor Substrate 62 3     

External Ids:    HGNC: 161731   Entrez Gene: 558162   Ensembl: ENSG000001011347   OMIM: 6083345   UniProtKB: Q9P1043   

Export aliases for DOK5 gene to outside databases

Previous GC identifers: GC20P052780 GC20P053730 GC20P053777 GC20P052525 GC20P049839


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOK5 Gene:
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins
involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to
mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins,
this protein does not interact with RASGAP. (provided by RefSeq, Jul 2008)

GeneCards Summary for DOK5 Gene:
DOK5 (docking protein 5) is a protein-coding gene. Diseases associated with DOK5 include bipolar disorder, and obesity. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and
plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in
neuronal differentiation

Gene Wiki entry for DOK5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOK5 gene promoter:
         Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOK5 promoter sequence
   Search Chromatin IP Primers for DOK5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.2   HGNC cytogenetic band: 20q13.2

DOK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK5 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P053092:  view genomic region     (about GC identifiers)

Start:
53,092,136 bp from pter      End:
53,267,710 bp from pter
Size:
175,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104 (See protein sequence)
Recommended Name: Docking protein 5  
Size: 306 amino acids; 35464 Da
Subunit: Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP
(By similarity)
1 PDB 3D structure from and Proteopedia for DOK5:
1J0W (3D)    
Secondary accessions: Q5T7Y0 Q5TE53 Q8TEW7 Q96H13 Q9BZ24 Q9NQF4 Q9Y411
Alternative splicing: 2 isoforms:  Q9P104-1   Q9P104-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOK5: NX_Q9P104

Explore proteomics data for DOK5 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOK5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060901.2  
    ENSEMBL proteins: 
     ENSP00000262593   ENSP00000379270  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9P104

    ProtoNet protein and cluster: Q9P104

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104
    Domain: PTB domain mediates receptor interaction (By similarity)
    Similarity: Belongs to the DOK family. Type B subfamily
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    DOK5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK5_HUMAN, Q9P104
    Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
    for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and
    plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in
    neuronal differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005158insulin receptor binding IEA--
         
    DOK5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DOK5:
     Increased G1 DNA content  Increased circadian rhythm amp 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOK5
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    Selected qRT-PCR Assays for microRNAs that regulate DOK5 (see all 10):
    hsa-miR-3678-3p hsa-miR-198 hsa-miR-92a hsa-miR-7-2* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidDOK5 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOK5 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling events regulated by Ret tyrosine kinase
    Signaling events regulated by Ret tyrosine kinase
    2BDNF signaling pathway
    BDNF signaling pathway


    2 BioSystems Pathways for DOK5
        BDNF signaling pathway
    Signaling events regulated by Ret tyrosine kinase



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOK5
    Interactions:

        GeneGlobe Interaction Network for DOK5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for DOK5 (Q9P1042, 3 ENSP000002625934) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158342, 3, ENSP000003116954MINT-67334 I2D: score=5 STRING: ENSP00000311695
    BNIP3LO602382, 3, ENSP000003700034MINT-66031 I2D: score=5 STRING: ENSP00000370003
    EGFRP005332, 3, ENSP000002754934MINT-74516 I2D: score=2 STRING: ENSP00000275493
    RETP079493, ENSP000003479424I2D: score=3 STRING: ENSP00000347942
    NTRK2Q166203, ENSP000002771204I2D: score=1 STRING: ENSP00000277120
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0007399nervous system development IEA--

    DOK5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOK5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DOK5 gene (2 alternative transcripts): 
    NM_018431.3  NM_177959.2  

    Unigene Cluster for DOK5:

    Docking protein 5
    Hs.656582  [show with all ESTs]
    Unigene Representative Sequence: NM_018431
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262593(uc002xwy.3) ENST00000491469 ENST00000395939 ENST00000484860

    miRNA
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    Block miRNA regulation of human, mouse, rat DOK5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOK5 (see all 10):
    hsa-miR-3678-3p hsa-miR-198 hsa-miR-92a hsa-miR-7-2* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidDOK5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DOK5
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOK5 (NM_018431)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK5
    Primer
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    OriGene qPCR primer pairs and template standards for DOK5
    OriGene qSTAR qPCR primer pairs in human, mouse for DOK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOK5
      QuantiTect SYBR Green Assays in human, mouse, rat DOK5
      QuantiFast Probe-based Assays in human, mouse, rat DOK5

    Additional mRNA sequence: 

    AF466368.1 AK313222.1 AL050069.1 BC008992.1 

    6 DOTS entries:

    DT.442649  DT.95278142  DT.100774364  DT.95278143  DT.92022013  DT.40127066 

    Selected AceView cDNA sequences (see all 87):

    AI822030 CR601525 AA883396 NM_177959 NM_018431 AF466368 BX459917 BF343504 
    CD671147 CR606944 BC008992 BQ445950 BP349897 AA962632 AW088406 BI758267 
    CR612289 CA415329 AL050069 CB117720 BX435064 AL537482 BQ182961 AI148169 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DOK5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
    SP1:                    -     -                 -                                             
    SP2:                          -                 -                                             
    SP3:                          -                 -           -                                 
    SP4:                                            -                                             
    SP5:                          -                                                               


    ECgene alternative splicing isoforms for DOK5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOK5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTCCTCAC
    DOK5 Expression
    About this image


    DOK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Ovary (Reproductive System)
             Cumulus Cells Antral Follicle
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
     
     Neurons
             Cholinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Cholinergic Amacrine Cells Inner Nuclear Layer
    DOK5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOK5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656582

    UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104
    Tissue specificity: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in
    activated peripheral blood T-lymphocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DOK5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dok51 , 5 docking protein 51, 5 89.25(n)1
    98.36(a)1
      2 (92.26 cM)5
    768291  NM_001163686.11  NP_001157158.11 
     1707318075 
    chicken
    (Gallus gallus)
    Aves DOK51 docking protein 5 84.53(n)
    93.14(a)
      419336  XM_417502.4  XP_417502.2 
    lizard
    (Anolis carolinensis)
    Reptilia DOK56
    docking protein 5
    86(a)
    1 ↔ 1
    GL343429.1(777239-787370)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dok51 docking protein 5 77.45(n)
    87.25(a)
      100496159  XM_002935385.2  XP_002935431.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BX323022.16
    Uncharacterized protein
    12(a)
    many ↔ many
    10(20067833-20098417) ENSDARG00000087271
    fruit fly
    (Drosophila melanogaster)
    Insecta Dok6
    Downstream of kinase
    9(a)
    1 → many
    X(7218251-7222839)


    ENSEMBL Gene Tree for DOK5 (if available)
    TreeFam Gene Tree for DOK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOK5 gene
    DOK62  DOK12  DOK42  DOK32  DOK22  
    2 SIMAP similar genes for DOK5 using alignment to 1 protein entry:     DOK5_HUMAN:
    DOK4    DOK6

    DOK5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOK5 (see all 4151)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1878996581,2
    --49837625(+) TTCCTC/TAGCTC 1 -- us2k10--------
    rs13300171,2
    C,F,O,A,H--53090283(-) CCATAG/AATAAT 1 -- us2k124Minor allele frequency- A:0.26MN NA NS EA WA CSA 2205
    rs1442631051,2
    C--53090390(+) AGCTCC/GTTATG 1 -- us2k10--------
    rs579273911,2
    C,F--53090445(+) TCTATA/GAATGA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs114750581,2
    C,F--53090508(+) TTTTT-/TAAGTT 1 -- us2k1 trp33Minor allele frequency- T:0.33NA CSA 6
    rs1154857531,2
    C,F--53090596(+) TTAAAA/GCATCA 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs739119131,2
    C,F--53090646(+) ATGTAG/ACAAAA 1 -- us2k12Minor allele frequency- A:0.08WA 120
    rs1386636861,2
    C--53090683(+) TTTTT-/GATTGT 1 -- us2k10--------
    rs575821501,2
    C,F--53090703(+) GTCTCG/AGTTCT 1 -- us2k14Minor allele frequency- A:0.09WA NA 242
    rs60232701,2
    C,F,A--53090730(+) GGAGGT/ATTCTG 1 -- us2k112Minor allele frequency- A:0.18NA WA CSA 374

    HapMap Linkage Disequilibrium report for DOK5 (53092136 - 53267710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DOK5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2441780CNV Deletion19546169
    esv2566495CNV Deletion19546169
    esv997407CNV Insertion20482838
    dgv67n68CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOK5
    DNA2.0 Custom Variant and Variant Library Synthesis for DOK5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608334    OMIM disorders: --

    3 diseases for DOK5:    
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    bipolar disorder    obesity    neuronitis


    DOK5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DOK5
    Human Genome Epidemiology (HuGE) Navigator: DOK5 (4 documents)

    Export disorders for DOK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOK5 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with DOK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)1, 2, 9 Favre C.... Nunes J.A. (Genes Immun. 2003)
    2. Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population. (PubMed id 20187968)1, 4 Tabassum R....Bharadwaj D. (BMC Med. Genet. 2010)
    3. A genome-wide association study of amygdala activation in youths with and without bipolar disorder. (PubMed id 20215924)1, 4 Liu X....McMahon F.J. (J Am Acad Child Adolesc Psychiatry 2010)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. (PubMed id 12730241)1, 2 Cai D.... Shoelson S.E. (J. Biol. Chem. 2003)
    7. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein. (PubMed id 12454490)1, 2 Shi N.... Rao Z. (Acta Crystallogr. D 2002)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. (PubMed id 11470823)1, 3 Grimm J....Birchmeier W. (J. Cell Biol. 2001)
    10. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PubMed id 23936387)1 A9stensson M....Torinsson-Naluai A.8. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55816 HGNC: 16173 AceView: DOK5 Ensembl:ENSG00000101134 euGenes: HUgn55816
    ECgene: DOK5 H-InvDB: DOK5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOK5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOK5 gene:
    Search GeneIP for patents involving DOK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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