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Aliases for DOK5 Gene

Aliases for DOK5 Gene

  • Docking Protein 5 2 3
  • Downstream Of Tyrosine Kinase 5 3 4
  • Insulin Receptor Substrate 6 3 4
  • C20orf180 3 4
  • IRS-6 3 4
  • IRS6 3 4
  • Chromosome 20 Open Reading Frame 180 2

External Ids for DOK5 Gene

Previous HGNC Symbols for DOK5 Gene

  • C20orf180

Previous GeneCards Identifiers for DOK5 Gene

  • GC20P052780
  • GC20P053730
  • GC20P053777
  • GC20P052525
  • GC20P053092
  • GC20P049839

Summaries for DOK5 Gene

Entrez Gene Summary for DOK5 Gene

  • The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DOK5 Gene

DOK5 (Docking Protein 5) is a Protein Coding gene. Among its related pathways are Signaling events regulated by Ret tyrosine kinase and BDNF signaling pathway. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK5 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation

Gene Wiki entry for DOK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK5 Gene

Genomics for DOK5 Gene

Regulatory Elements for DOK5 Gene

Transcription factor binding sites by QIAGEN in the DOK5 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOK5 Gene

54,475,597 bp from pter
54,651,171 bp from pter
175,575 bases
Plus strand

Genomic View for DOK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK5 Gene

Proteins for DOK5 Gene

  • Protein details for DOK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Docking protein 5
    Protein Accession:
    Secondary Accessions:
    • Q5T7Y0
    • Q5TE53
    • Q8TEW7
    • Q96H13
    • Q9BZ24
    • Q9NQF4
    • Q9Y411

    Protein attributes for DOK5 Gene

    306 amino acids
    Molecular mass:
    35464 Da
    Quaternary structure:
    • Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).

    Three dimensional structures from OCA and Proteopedia for DOK5 Gene

    Alternative splice isoforms for DOK5 Gene


neXtProt entry for DOK5 Gene

Proteomics data for DOK5 Gene at MOPED

Post-translational modifications for DOK5 Gene

  • Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOK5 Gene

No data available for DME Specific Peptides for DOK5 Gene

Domains for DOK5 Gene

Gene Families for DOK5 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for DOK5 Gene

Suggested Antigen Peptide Sequences for DOK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P104
  • PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
  • Belongs to the DOK family. Type B subfamily.
genes like me logo Genes that share domains with DOK5: view

Function for DOK5 Gene

Molecular function for DOK5 Gene

UniProtKB/Swiss-Prot Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation

Gene Ontology (GO) - Molecular Function for DOK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005158 insulin receptor binding IEA --
genes like me logo Genes that share ontologies with DOK5: view

Phenotypes for DOK5 Gene

GenomeRNAi human phenotypes for DOK5:
genes like me logo Genes that share phenotypes with DOK5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DOK5 Gene

Localization for DOK5 Gene

Subcellular locations from

Jensen Localization Image for DOK5 Gene COMPARTMENTS Subcellular localization image for DOK5 gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DOK5 Gene

Pathways for DOK5 Gene

genes like me logo Genes that share pathways with DOK5: view

Pathways by source for DOK5 Gene

Gene Ontology (GO) - Biological Process for DOK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with DOK5: view

Transcripts for DOK5 Gene

Unigene Clusters for DOK5 Gene

Docking protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOK5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOK5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for DOK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOK5 Gene

mRNA expression in normal human tissues for DOK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK5 Gene

This gene is overexpressed in Muscle - Skeletal (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DOK5 Gene

SOURCE GeneReport for Unigene cluster for DOK5 Gene Hs.656582

mRNA Expression by UniProt/SwissProt for DOK5 Gene

Tissue specificity: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
genes like me logo Genes that share expressions with DOK5: view

In Situ Assay Products

Orthologs for DOK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DOK5 35
  • 99.56 (n)
  • 100 (a)
DOK5 36
  • 100 (a)
(Bos Taurus)
Mammalia DOK5 35
  • 90.74 (n)
  • 94.77 (a)
DOK5 36
  • 94 (a)
(Canis familiaris)
Mammalia DOK5 35
  • 92.42 (n)
  • 97.55 (a)
DOK5 36
  • 93 (a)
(Mus musculus)
Mammalia Dok5 35
  • 89.25 (n)
  • 98.36 (a)
Dok5 16
Dok5 36
  • 98 (a)
(Monodelphis domestica)
Mammalia DOK5 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia DOK5 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Dok5 35
  • 90.52 (n)
  • 97.39 (a)
(Gallus gallus)
Aves DOK5 35
  • 84.53 (n)
  • 93.14 (a)
DOK5 36
  • 87 (a)
(Anolis carolinensis)
Reptilia DOK5 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dok5 35
  • 77.45 (n)
  • 87.25 (a)
(Danio rerio)
Actinopterygii BX323022.1 36
  • 12 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dok 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 36
  • 16 (a)
Species with no ortholog for DOK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK5 Gene

Gene Tree for DOK5 (if available)
Gene Tree for DOK5 (if available)

Paralogs for DOK5 Gene

Paralogs for DOK5 Gene

Selected SIMAP similar genes for DOK5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DOK5: view

Variants for DOK5 Gene

Sequence variations from dbSNP and Humsavar for DOK5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2840 -- 54,651,037(-) ACTAA(C/T)GGGTT utr-variant-3-prime
rs2841 -- 54,651,054(-) GTAAC(C/T)CTGTA utr-variant-3-prime
rs2842 -- 54,651,043(-) AACAA(C/T)ACTAA utr-variant-3-prime
rs2843 -- 54,651,096(-) AAAAG(C/G)GGGGT utr-variant-3-prime
rs15899 -- 54,651,088(-) GGTAA(A/G)GGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DOK5 Gene

Variant ID Type Subtype PubMed ID
dgv67n68 CNV Gain 17160897
esv2441780 CNV Deletion 19546169
esv2566495 CNV Deletion 19546169
esv997407 CNV Insertion 20482838

Relevant External Links for DOK5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK5 Gene

Disorders for DOK5 Gene

Relevant External Links for DOK5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DOK5: view

No data available for UniProtKB/Swiss-Prot for DOK5 Gene

Publications for DOK5 Gene

  1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C. … Nunes J.A. (Genes Immun. 2003) 3 4 23
  2. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. (PMID: 11470823) Grimm J. … Birchmeier W. (J. Cell Biol. 2001) 2 3
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein. (PMID: 12454490) Shi N. … Rao Z. (Acta Crystallogr. D 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DOK5 Gene

Sources for DOK5 Gene

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