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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DOK5 Gene

protein-coding GIFtS: 57
GCID: GC20P053092

docking protein 5

(Previous name: chromosome 20 open reading frame 180 )
(Previous symbol: C20orf180)

Explore 3 diseases affiliated with
DOK5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Docking Protein 5¹ ²		IRS-6² ³
C20orf180¹ ² ³		IRS6² ³
Downstream Of Tyrosine Kinase 5² ³		Chromosome 20 Open Reading Frame 180¹
Insulin Receptor Substrate 6² ³		DJ805C22.1¹

External Ids:	HGNC: 16173¹	Entrez Gene: 55816²	Ensembl: ENSG00000101134⁷	OMIM: 608334⁵	UniProtKB: Q9P104³

Export aliases for DOK5 gene to outside databases

Previous GC identifers: GC20P052780 GC20P053730 GC20P053777 GC20P052525 GC20P049839

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOK5:

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins

involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to

mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this

protein does not interact with RASGAP. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104

Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the

assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive

role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal

differentiation

Gene Wiki entry for DOK5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DOK5 gene promoter:
Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOK5 promoter sequence

Search SABiosciences Chromatin IP Primers for DOK5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOK5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.2 HGNC cytogenetic band: 20q13.2

DOK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK5 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P053092: view genomic region (about GC identifiers)

Start:	53,092,136 bp from pter	End:	53,267,710 bp from pter
Size:	175,575 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104 (See protein sequence)

Recommended Name: Docking protein 5

Size: 306 amino acids; 35464 Da

Subunit: Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By

similarity)

1 PDB 3D structure from and Proteopedia for DOK5:

1J0W (3D)

Secondary accessions: Q5T7Y0 Q5TE53 Q8TEW7 Q96H13 Q9BZ24 Q9NQF4 Q9Y411

Alternative splicing: 2 isoforms: Q9P104-1 Q9P104-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOK5: NX_Q9P104

Post-translational modifications:

Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P104

DOK5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060901.2

ENSEMBL proteins:

ENSP00000262593 ENSP00000379270

Human Recombinant Protein Products for DOK5:

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	Uscn ELISAs and CLIAs for DOK5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DOK5 for domains About GeneDecksing

3 InterPro domains/families:

IPR002404 Insln_rcpt_S1

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q9P104

ProtoNet protein and cluster: Q9P104

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104

Domain: PTB domain mediates receptor interaction (By similarity)

Similarity: Belongs to the DOK family. Type B subfamily

Similarity: Contains 1 IRS-type PTB domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DOK5_HUMAN, Q9P104

Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the

assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive

role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal

differentiation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005158	insulin receptor binding	IEA	--
GO:0005543	phospholipid binding	IEA	--

DOK5 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for DOK5:

Increased G1 DNA content

Increased circadian rhythm amp

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DOK5

miRNA Products:		OriGene 3'-UTR Clone: DOK5 Browse MicroRNA Expression Plasmids
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		hsa-miR-3678-3p hsa-miR-198 hsa-miR-92a hsa-miR-7-2* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-7-1*

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling events regulated by Ret tyrosine kinase

Signaling events regulated by Ret tyrosine kinase

1.00

1 BioSystems Pathway for DOK5

Signaling events regulated by Ret tyrosine kinase

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DOK5

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for DOK5 (Q9P104^{2, 3} ENSP00000262593⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CCDC85B	Q15834²^,³, ENSP00000311695⁴	MINT-67334 I2D: score=5 STRING: ENSP00000311695
BNIP3L	O60238²^,³, ENSP00000370003⁴	MINT-66031 I2D: score=5 STRING: ENSP00000370003
EGFR	P00533²^,³, ENSP00000275493⁴	MINT-74516 I2D: score=2 STRING: ENSP00000275493
RET	P07949³, ENSP00000347942⁴	I2D: score=3 STRING: ENSP00000347942
NTRK2	Q16620³, ENSP00000277120⁴	I2D: score=1 STRING: ENSP00000277120

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	IEA	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IEA	--
GO:0007399	nervous system development	IEA	--

DOK5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DOK5
Search CenterWatch for drugs/clinical trials and news about DOK5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DOK5 gene (2 alternative transcripts):

NM_018431.3 NM_177959.2

Unigene Cluster for DOK5:

Docking protein 5

Hs.656582 [show with all ESTs]

Unigene Representative Sequence: NM_018431

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262593(uc002xwy.3) ENST00000491469 ENST00000395939 ENST00000484860

miRNA Products:		OriGene 3'-UTR Clone: DOK5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOK5
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate DOK5 (see all 10):
		hsa-miR-3678-3p hsa-miR-198 hsa-miR-92a hsa-miR-7-2* hsa-miR-25 hsa-miR-367 hsa-miR-32 hsa-miR-7-1*

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Additional cDNA sequence:

AF466368.1 AK313222.1 AL050069.1 BC008992.1

6 DOTS entries:

DT.442649 DT.95278142 DT.100774364 DT.95278143 DT.92022013 DT.40127066

24/87 AceView cDNA sequences (see all 87):

AA883396 BP349897 AA962632 CR612289 BF343504 BC008992 NM_177959 CD671147

BX459917 AF466368 AI822030 AW088406 BQ445950 CR606944 CR601525 NM_018431

BI758267 AL537482 BX463904 AI094643 AI769246 AI357651 BX455570 BX435064

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DOK5 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b
SP1:							-		-						-
SP2:									-						-
SP3:									-						-				-
SP4:															-
SP5:									-

ECgene alternative splicing isoforms for DOK5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DOK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTCCTCAC

About this image

DOK5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

See DOK5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOK5

SOURCE GeneReport for Unigene cluster: Hs.656582

UniProtKB/Swiss-Prot: DOK5_HUMAN, Q9P104

Tissue specificity: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated

peripheral blood T-lymphocytes

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DOK5 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DOK5¹	docking protein 5	84.53(n) 93.14(a)		419336 XM_417502.3 XP_417502.2
lizard (Anolis carolinensis)	Reptilia	DOK5⁶	--	86(a)	1 ↔ 1	GL343429.1(777239-787370)
zebrafish (Danio rerio)	Actinopterygii	dok6⁶	docking protein 6	60(a)	1 → many	24(14841464-15015801)

ENSEMBL Gene Tree for DOK5 (if available)
TreeFam Gene Tree for DOK5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DOK5 gene

DOK6² DOK4²

2 SIMAP similar genes for DOK5 using alignment to 1 protein entry: DOK5_HUMAN:

DOK4 DOK6

DOK5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1330017^1,2	C,F,O,A,H	--	53090283(-)	`CCATAG/AATAAT`	1	--	us2k¹		24		MN NA NS EA WA CSA	2205
rs144263105^1,2		--	53090390(+)	`AGCTCC/GTTATG`	1	--	us2k¹		0	--	--	--	--
rs57927391^1,2	F	--	53090445(+)	`TCTATA/GAATGA`	1	--	us2k¹		1		WA	118
rs11475058^1,2	C,F	--	53090508(+)	`TTTTT-/TAAGTT`	1	--	us2k¹ trp³		3		NA CSA	6
rs115485753^1,2		--	53090596(+)	`TTAAAA/GCATCA`	1	--	us2k¹		1		WA	118
rs73911913^1,2	C	--	53090646(+)	`ATGTAG/ACAAAA`	1	--	us2k¹		2		WA	120
rs138663686^1,2	C	--	53090683(+)	`TTTTT-/GATTGT`	1	--	us2k¹		0	--	--	--	--
rs57582150^1,2	C,F	--	53090703(+)	`GTCTCG/AGTTCT`	1	--	us2k¹		4		WA NA	242
rs6023270^1,2	C,F,A	--	53090730(+)	`GGAGGT/ATTCTG`	1	--	us2k¹		12		NA WA CSA	374
rs191688107^1,2		--	53090750(+)	`TGAAAC/TTCATC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DOK5 (53092136 - 53267710 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DOK5
1 CNV: 102992

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOK5

DNA2.0 Custom Variant and Variant Library Synthesis for DOK5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DOK5 for disorders           About GeneDecksing

OMIM gene information: 608334    OMIM disorders: --

3 diseases for DOK5:    About MalaCards

bipolar disorder obesity neuronitis

Human Genome Epidemiology (HuGE) Navigator: DOK5 (4 documents)

Export disorders for DOK5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DOK5 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with DOK5)

Utopia: connect your pdf to the dynamic
world of online information

DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)^{1, 2, 9} Favre C....Nunes J.A. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. (PubMed id 12730241)^{1, 2} Cai D.... Shoelson S.E. (2003)
Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein. (PubMed id 12454490)^{1, 2} Shi N.... Rao Z. (2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. (PubMed id 11470823)^{1, 3} Grimm J....Birchmeier W. (2001)
Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population. (PubMed id 20187968)¹ Tabassum R....Bharadwaj D. (2010)
A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)¹ He C....Hunter D.J. (2010)
A genome-wide association study of amygdala activatio n in youths with and without bipolar disorder. (PubMed id 20215924)¹ Liu X....McMahon F.J. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55816	HGNC: 16173	AceView: DOK5	Ensembl:ENSG00000101134	euGenes: HUgn55816
ECgene: DOK5	H-InvDB: DOK5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DOK5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DOK5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DOK5 gene:
Search GeneIP for patents involving DOK5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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docking protein 5

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