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Aliases for DOK5 Gene

Aliases for DOK5 Gene

  • Docking Protein 5 2 3 5
  • Downstream Of Tyrosine Kinase 5 3 4
  • Insulin Receptor Substrate 6 3 4
  • C20orf180 3 4
  • IRS-6 3 4
  • IRS6 3 4
  • Chromosome 20 Open Reading Frame 180 2

External Ids for DOK5 Gene

Previous HGNC Symbols for DOK5 Gene

  • C20orf180

Previous GeneCards Identifiers for DOK5 Gene

  • GC20P052780
  • GC20P053730
  • GC20P053777
  • GC20P052525
  • GC20P053092
  • GC20P049839

Summaries for DOK5 Gene

Entrez Gene Summary for DOK5 Gene

  • The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DOK5 Gene

DOK5 (Docking Protein 5) is a Protein Coding gene. Among its related pathways are RET signaling and Developmental Biology. GO annotations related to this gene include signal transducer activity, downstream of receptor and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot for DOK5 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

Gene Wiki entry for DOK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK5 Gene

Genomics for DOK5 Gene

Regulatory Elements for DOK5 Gene

Enhancers for DOK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F054254 1 Ensembl ENCODE 9.6 -219.0 -219048 2.9 SMARCC1 HLF JUN CEBPB EP300 KAT2B ZNF217 JUND GATA3 SMARCA4 DOK5 ENSG00000280041
GH20F054559 0.8 ENCODE 11 +83.9 83905 0.2 ATF1 CREB3L1 TAL1 ZNF175 BACH1 ZNF766 NCOR1 ADNP SCRT2 ZNF584 DOK5 RNU4ATAC7P
GH20F054207 1.1 ENCODE 6.1 -267.0 -267045 2.3 PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 DOK5 PFDN4 ENSG00000280041
GH20F054221 0.9 Ensembl ENCODE 6.2 -253.6 -253572 1.4 HMG20B HLF CEBPB RAD21 YY1 ATF3 CEBPA ZBTB33 CYP24A1 DOK5 PFDN4 ENSG00000280041
GH20F054344 1.1 Ensembl ENCODE 4.7 -129.8 -129752 1.8 GTF2F1 TBP JUN BMI1 RAD21 BRCA1 RFX5 RCOR1 NFE2 FOS DOK5 ENSG00000280041
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOK5 on UCSC Golden Path with GeneCards custom track

Promoters for DOK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001838623 728 2401 SOX13 SUZ12 RAD21 RARA ZFHX2 POLR2A EGR2 EZH2 GATAD2A SOX5

Transcription factor binding sites by QIAGEN in the DOK5 gene promoter:

Genomic Location for DOK5 Gene

Chromosome:
20
Start:
54,475,472 bp from pter
End:
54,651,171 bp from pter
Size:
175,700 bases
Orientation:
Plus strand

Genomic View for DOK5 Gene

Genes around DOK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK5 Gene

Proteins for DOK5 Gene

  • Protein details for DOK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P104-DOK5_HUMAN
    Recommended name:
    Docking protein 5
    Protein Accession:
    Q9P104
    Secondary Accessions:
    • Q5T7Y0
    • Q5TE53
    • Q8TEW7
    • Q96H13
    • Q9BZ24
    • Q9NQF4
    • Q9Y411

    Protein attributes for DOK5 Gene

    Size:
    306 amino acids
    Molecular mass:
    35464 Da
    Quaternary structure:
    • Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).

    Three dimensional structures from OCA and Proteopedia for DOK5 Gene

    Alternative splice isoforms for DOK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK5 Gene

Post-translational modifications for DOK5 Gene

  • Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOK5 Gene

No data available for DME Specific Peptides for DOK5 Gene

Domains & Families for DOK5 Gene

Gene Families for DOK5 Gene

Protein Domains for DOK5 Gene

Suggested Antigen Peptide Sequences for DOK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P104

UniProtKB/Swiss-Prot:

DOK5_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type B subfamily.
Domain:
  • PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOK family. Type B subfamily.
genes like me logo Genes that share domains with DOK5: view

Function for DOK5 Gene

Molecular function for DOK5 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

Gene Ontology (GO) - Molecular Function for DOK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor IEA --
GO:0005158 insulin receptor binding IEA --
genes like me logo Genes that share ontologies with DOK5: view
genes like me logo Genes that share phenotypes with DOK5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DOK5 Gene

Localization for DOK5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOK5 gene
Compartment Confidence
cytosol 5
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DOK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DOK5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOK5 Gene

Pathways & Interactions for DOK5 Gene

genes like me logo Genes that share pathways with DOK5: view

Pathways by source for DOK5 Gene

SIGNOR curated interactions for DOK5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DOK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007399 nervous system development IEA --
GO:0051386 regulation of neurotrophin TRK receptor signaling pathway IMP 23954828
genes like me logo Genes that share ontologies with DOK5: view

Drugs & Compounds for DOK5 Gene

(10) Drugs for DOK5 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2829
Cytarabine Approved, Investigational Pharma 1093
Daunorubicin Approved Pharma DNA topoisomerase II inhibitor 264
Dexamethasone Approved, Investigational, Vet_approved Pharma Agonist 2084
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1714
genes like me logo Genes that share compounds with DOK5: view

Transcripts for DOK5 Gene

Unigene Clusters for DOK5 Gene

Docking protein 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOK5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for DOK5 Gene

GeneLoc Exon Structure for
DOK5
ECgene alternative splicing isoforms for
DOK5

Expression for DOK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DOK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for DOK5 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DOK5 Gene



Protein tissue co-expression partners for DOK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DOK5 Gene:

DOK5

SOURCE GeneReport for Unigene cluster for DOK5 Gene:

Hs.656582

mRNA Expression by UniProt/SwissProt for DOK5 Gene:

Q9P104-DOK5_HUMAN
Tissue specificity: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
genes like me logo Genes that share expression patterns with DOK5: view

Orthologs for DOK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK5 34 35
  • 99.56 (n)
oppossum
(Monodelphis domestica)
Mammalia DOK5 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOK5 34 35
  • 92.42 (n)
cow
(Bos Taurus)
Mammalia DOK5 34 35
  • 90.74 (n)
rat
(Rattus norvegicus)
Mammalia Dok5 34
  • 90.52 (n)
mouse
(Mus musculus)
Mammalia Dok5 34 16 35
  • 89.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DOK5 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK5 34 35
  • 84.53 (n)
lizard
(Anolis carolinensis)
Reptilia DOK5 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dok5 34
  • 77.45 (n)
zebrafish
(Danio rerio)
Actinopterygii BX323022.1 35
  • 12 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dok 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 35
  • 16 (a)
OneToMany
Species where no ortholog for DOK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK5 Gene

ENSEMBL:
Gene Tree for DOK5 (if available)
TreeFam:
Gene Tree for DOK5 (if available)

Paralogs for DOK5 Gene

Paralogs for DOK5 Gene

(2) SIMAP similar genes for DOK5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DOK5: view

Variants for DOK5 Gene

Sequence variations from dbSNP and Humsavar for DOK5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10154005 -- 54,627,578(+) AAAGC(A/G)GAGAG intron-variant
rs1034094 -- 54,525,295(-) TTCCC(A/T)TTTGT intron-variant
rs10485783 -- 54,638,523(-) TTAAC(C/T)GGTCA intron-variant
rs10485784 -- 54,576,175(-) GCATC(A/G)TCTTT intron-variant
rs10485785 -- 54,556,095(-) TGTGC(C/T)TATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOK5 Gene

Variant ID Type Subtype PubMed ID
nsv586282 CNV loss 21841781
nsv586224 CNV gain 21841781
nsv1136553 CNV deletion 24896259
nsv1067497 CNV gain 25217958
nsv1060552 CNV gain 25217958
esv997407 CNV insertion 20482838
esv3646140 CNV loss 21293372
esv3646139 CNV loss 21293372
esv3646138 CNV loss 21293372
esv2760673 CNV loss 21179565
esv2566495 CNV deletion 19546169
esv2441780 CNV deletion 19546169
dgv67n68 CNV gain 17160897
dgv2264n106 CNV tandem duplication 24896259

Variation tolerance for DOK5 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK5 Gene

Disorders for DOK5 Gene

Relevant External Links for DOK5

Genetic Association Database (GAD)
DOK5
Human Genome Epidemiology (HuGE) Navigator
DOK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK5

No disorders were found for DOK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK5 Gene

Publications for DOK5 Gene

  1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C. … Nunes J.A. (Genes Immun. 2003) 3 4 22 64
  2. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  3. Evaluation of DOK5 as a susceptibility gene for type 2 diabetes and obesity in North Indian population. (PMID: 20187968) Tabassum R. … Bharadwaj D. (BMC Med. Genet. 2010) 3 46 64
  4. A genome-wide association study of amygdala activation in youths with and without bipolar disorder. (PMID: 20215924) Liu X. … McMahon F.J. (J Am Acad Child Adolesc Psychiatry 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DOK5 Gene

Sources for DOK5 Gene

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