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Aliases for DOK5 Gene

Aliases for DOK5 Gene

  • Docking Protein 5 2 3 5
  • Downstream Of Tyrosine Kinase 5 3 4
  • Insulin Receptor Substrate 6 3 4
  • C20orf180 3 4
  • IRS-6 3 4
  • IRS6 3 4
  • Chromosome 20 Open Reading Frame 180 2

External Ids for DOK5 Gene

Previous HGNC Symbols for DOK5 Gene

  • C20orf180

Previous GeneCards Identifiers for DOK5 Gene

  • GC20P052780
  • GC20P053730
  • GC20P053777
  • GC20P052525
  • GC20P053092
  • GC20P049839

Summaries for DOK5 Gene

Entrez Gene Summary for DOK5 Gene

  • The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DOK5 Gene

DOK5 (Docking Protein 5) is a Protein Coding gene. Among its related pathways are BDNF signaling pathway and Signaling events regulated by Ret tyrosine kinase. GO annotations related to this gene include receptor signaling protein activity and insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK5 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

Gene Wiki entry for DOK5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK5 Gene

Genomics for DOK5 Gene

Regulatory Elements for DOK5 Gene

Promoters for DOK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOK5 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DOK5 gene promoter:

Genomic Location for DOK5 Gene

Chromosome:
20
Start:
54,475,472 bp from pter
End:
54,651,171 bp from pter
Size:
175,700 bases
Orientation:
Plus strand

Genomic View for DOK5 Gene

Genes around DOK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK5 Gene

Proteins for DOK5 Gene

  • Protein details for DOK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P104-DOK5_HUMAN
    Recommended name:
    Docking protein 5
    Protein Accession:
    Q9P104
    Secondary Accessions:
    • Q5T7Y0
    • Q5TE53
    • Q8TEW7
    • Q96H13
    • Q9BZ24
    • Q9NQF4
    • Q9Y411

    Protein attributes for DOK5 Gene

    Size:
    306 amino acids
    Molecular mass:
    35464 Da
    Quaternary structure:
    • Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).

    Three dimensional structures from OCA and Proteopedia for DOK5 Gene

    Alternative splice isoforms for DOK5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK5 Gene

Proteomics data for DOK5 Gene at MOPED

Post-translational modifications for DOK5 Gene

  • Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOK5 Gene

Antibody Products

No data available for DME Specific Peptides for DOK5 Gene

Domains & Families for DOK5 Gene

Gene Families for DOK5 Gene

Protein Domains for DOK5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DOK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P104

UniProtKB/Swiss-Prot:

DOK5_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type B subfamily.
Domain:
  • PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOK family. Type B subfamily.
genes like me logo Genes that share domains with DOK5: view

Function for DOK5 Gene

Molecular function for DOK5 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

Gene Ontology (GO) - Molecular Function for DOK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IEA --
genes like me logo Genes that share ontologies with DOK5: view
genes like me logo Genes that share phenotypes with DOK5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DOK5 Gene

Localization for DOK5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOK5 Gene COMPARTMENTS Subcellular localization image for DOK5 gene
Compartment Confidence
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DOK5 Gene

Pathways & Interactions for DOK5 Gene

genes like me logo Genes that share pathways with DOK5: view

Pathways by source for DOK5 Gene

SIGNOR curated interactions for DOK5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DOK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with DOK5: view

Drugs & Compounds for DOK5 Gene

No Compound Related Data Available

Transcripts for DOK5 Gene

Unigene Clusters for DOK5 Gene

Docking protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOK5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for DOK5 Gene

GeneLoc Exon Structure for
DOK5
ECgene alternative splicing isoforms for
DOK5

Expression for DOK5 Gene

mRNA expression in normal human tissues for DOK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for DOK5 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DOK5 Gene



SOURCE GeneReport for Unigene cluster for DOK5 Gene Hs.656582

mRNA Expression by UniProt/SwissProt for DOK5 Gene

Q9P104-DOK5_HUMAN
Tissue specificity: Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.
genes like me logo Genes that share expression patterns with DOK5: view

Protein tissue co-expression partners for DOK5 Gene

Primer Products

In Situ Assay Products

Orthologs for DOK5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOK5 35
  • 90.74 (n)
  • 94.77 (a)
DOK5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOK5 35
  • 92.42 (n)
  • 97.55 (a)
DOK5 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dok5 35
  • 89.25 (n)
  • 98.36 (a)
Dok5 16
Dok5 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DOK5 35
  • 99.56 (n)
  • 100 (a)
DOK5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dok5 35
  • 90.52 (n)
  • 97.39 (a)
oppossum
(Monodelphis domestica)
Mammalia DOK5 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOK5 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK5 35
  • 84.53 (n)
  • 93.14 (a)
DOK5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOK5 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dok5 35
  • 77.45 (n)
  • 87.25 (a)
zebrafish
(Danio rerio)
Actinopterygii BX323022.1 36
  • 12 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dok 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 36
  • 16 (a)
OneToMany
Species with no ortholog for DOK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK5 Gene

ENSEMBL:
Gene Tree for DOK5 (if available)
TreeFam:
Gene Tree for DOK5 (if available)

Paralogs for DOK5 Gene

Paralogs for DOK5 Gene

(2) SIMAP similar genes for DOK5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DOK5: view

Variants for DOK5 Gene

Sequence variations from dbSNP and Humsavar for DOK5 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2840 -- 54,651,037(-) ACTAA(C/T)GGGTT utr-variant-3-prime
rs2841 -- 54,651,054(-) GTAAC(C/T)CTGTA utr-variant-3-prime
rs2842 -- 54,651,043(-) AACAA(C/T)ACTAA utr-variant-3-prime
rs2843 -- 54,651,096(-) AAAAG(C/G)GGGGT utr-variant-3-prime
rs15899 -- 54,651,088(-) GGTAA(A/G)GGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DOK5 Gene

Variant ID Type Subtype PubMed ID
dgv67n68 CNV Gain 17160897
esv2441780 CNV Deletion 19546169
esv2566495 CNV Deletion 19546169
esv997407 CNV Insertion 20482838

Variation tolerance for DOK5 Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK5 Gene

HapMap Linkage Disequilibrium report
DOK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK5 Gene

Disorders for DOK5 Gene

Relevant External Links for DOK5

Genetic Association Database (GAD)
DOK5
Human Genome Epidemiology (HuGE) Navigator
DOK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK5

No disorders were found for DOK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK5 Gene

Publications for DOK5 Gene

  1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C. … Nunes J.A. (Genes Immun. 2003) 3 4 23 67
  2. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. (PMID: 11470823) Grimm J. … Birchmeier W. (J. Cell Biol. 2001) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis. (PMID: 24551065) Yasuoka H. … Feghali-Bostwick C.A. (PLoS ONE 2014) 3
  5. Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study. (PMID: 23192668) Kraja A.T. … Arnett D.K. (Lipids 2013) 3

Products for DOK5 Gene

Sources for DOK5 Gene

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