Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DOK4 Gene

Aliases for DOK4 Gene

  • Docking Protein 4 2 3 5
  • Downstream Of Tyrosine Kinase 4 3 4
  • Insulin Receptor Substrate 5 3 4
  • IRS-5 3 4
  • IRS5 3 4

External Ids for DOK4 Gene

Previous GeneCards Identifiers for DOK4 Gene

  • GC16M047901
  • GC16M057565
  • GC16M057240
  • GC16M057281
  • GC16M056063
  • GC16M043373

Summaries for DOK4 Gene

GeneCards Summary for DOK4 Gene

DOK4 (Docking Protein 4) is a Protein Coding gene. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Signaling events regulated by Ret tyrosine kinase. GO annotations related to this gene include receptor signaling protein activity and insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK4 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

Gene Wiki entry for DOK4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK4 Gene

Genomics for DOK4 Gene

Regulatory Elements for DOK4 Gene

Promoters for DOK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DOK4 Gene

Chromosome:
16
Start:
57,471,922 bp from pter
End:
57,487,327 bp from pter
Size:
15,406 bases
Orientation:
Minus strand

Genomic View for DOK4 Gene

Genes around DOK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK4 Gene

Proteins for DOK4 Gene

  • Protein details for DOK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEW6-DOK4_HUMAN
    Recommended name:
    Docking protein 4
    Protein Accession:
    Q8TEW6
    Secondary Accessions:
    • O75209
    • Q9BTP2
    • Q9NVV3

    Protein attributes for DOK4 Gene

    Size:
    326 amino acids
    Molecular mass:
    37028 Da
    Quaternary structure:
    • Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires phosphorylation of RET Tyr-1062 (By similarity).
    SequenceCaution:
    • Sequence=AAC24310.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DOK4 Gene

Proteomics data for DOK4 Gene at MOPED

Post-translational modifications for DOK4 Gene

  • Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DOK4 Gene

Domains & Families for DOK4 Gene

Gene Families for DOK4 Gene

Protein Domains for DOK4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DOK4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEW6

UniProtKB/Swiss-Prot:

DOK4_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type B subfamily.
Domain:
  • PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOK family. Type B subfamily.
genes like me logo Genes that share domains with DOK4: view

Function for DOK4 Gene

Molecular function for DOK4 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.

Gene Ontology (GO) - Molecular Function for DOK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IEA --
genes like me logo Genes that share ontologies with DOK4: view

Phenotypes for DOK4 Gene

GenomeRNAi human phenotypes for DOK4:
genes like me logo Genes that share phenotypes with DOK4: view

Animal Model Products

miRNA for DOK4 Gene

miRTarBase miRNAs that target DOK4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOK4 Gene

Localization for DOK4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOK4 Gene COMPARTMENTS Subcellular localization image for DOK4 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DOK4 Gene

Pathways & Interactions for DOK4 Gene

genes like me logo Genes that share pathways with DOK4: view

Pathways by source for DOK4 Gene

1 BioSystems pathway for DOK4 Gene
1 Qiagen pathway for DOK4 Gene

SIGNOR curated interactions for DOK4 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for DOK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
genes like me logo Genes that share ontologies with DOK4: view

Drugs & Compounds for DOK4 Gene

(1) Drugs for DOK4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DOK4: view

Transcripts for DOK4 Gene

Unigene Clusters for DOK4 Gene

Docking protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOK4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e ^ 12a ·
SP1: - -
SP2: -
SP3:
SP4: - - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - -
SP12: - - - - - -
SP13: - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - -
SP15: - - - - - - - - - -
SP16:
SP17: - - - - -
SP18: - - - - - - -

ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for DOK4 Gene

GeneLoc Exon Structure for
DOK4
ECgene alternative splicing isoforms for
DOK4

Expression for DOK4 Gene

mRNA expression in normal human tissues for DOK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOK4 Gene

This gene is overexpressed in Bone marrow stromal cell (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DOK4 Gene



SOURCE GeneReport for Unigene cluster for DOK4 Gene Hs.279832

mRNA Expression by UniProt/SwissProt for DOK4 Gene

Q8TEW6-DOK4_HUMAN
Tissue specificity: Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells.
genes like me logo Genes that share expression patterns with DOK4: view

Protein tissue co-expression partners for DOK4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DOK4 Gene

Orthologs for DOK4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK4 36
  • 100 (a)
OneToOne
DOK4 35
  • 99.8 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia DOK4 36
  • 98 (a)
OneToOne
LOC618756 35
  • 93.56 (n)
  • 98.47 (a)
dog
(Canis familiaris)
Mammalia DOK4 35
  • 92.21 (n)
  • 98.77 (a)
DOK4 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dok4 16
Dok4 35
  • 91.28 (n)
  • 98.46 (a)
Dok4 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOK4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOK4 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dok4 35
  • 91.9 (n)
  • 98.15 (a)
chicken
(Gallus gallus)
Aves DOK4 35
  • 83.61 (n)
  • 90.1 (a)
DOK4 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOK4 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dok4-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dok4 35
  • 71.81 (n)
  • 76.14 (a)
zebrafish
(Danio rerio)
Actinopterygii CR376738.1 36
  • 74 (a)
OneToOne
LOC568912 35
  • 72.61 (n)
  • 80.86 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dok 36
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 36
  • 15 (a)
OneToMany
Species with no ortholog for DOK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK4 Gene

ENSEMBL:
Gene Tree for DOK4 (if available)
TreeFam:
Gene Tree for DOK4 (if available)

Paralogs for DOK4 Gene

Paralogs for DOK4 Gene

genes like me logo Genes that share paralogs with DOK4: view

Variants for DOK4 Gene

Sequence variations from dbSNP and Humsavar for DOK4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs223826 -- 57,483,159(+) GGGTT(C/G)GGAAG intron-variant
rs477025 -- 57,475,048(+) TCCCT(C/T)CCTCT intron-variant
rs739813 -- 57,479,164(-) GGCAG(A/G)CGGCT intron-variant
rs604965 -- 57,487,362(+) AATTT(C/T)TGGGG upstream-variant-2KB
rs663133 -- 57,482,890(-) GCAGG(C/T)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOK4 Gene

Variant ID Type Subtype PubMed ID
nsv906724 CNV Loss 21882294
nsv833245 CNV Loss 17160897
nsv906725 CNV Loss 21882294
nsv906726 CNV Loss 21882294

Variation tolerance for DOK4 Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK4 Gene

HapMap Linkage Disequilibrium report
DOK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK4 Gene

Disorders for DOK4 Gene

Relevant External Links for DOK4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK4

No disorders were found for DOK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK4 Gene

Publications for DOK4 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3 4 67
  2. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C. … Nunes J.A. (Genes Immun. 2003) 3 23
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for DOK4 Gene

Sources for DOK4 Gene

Back to Top

Content