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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOK4 Gene

protein-coding   GIFtS: 54
GCID: GC16M057505

Docking Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Docking Protein 41 2
Downstream Of Tyrosine Kinase 42 3
Insulin Receptor Substrate 52 3
IRS-52 3
IRS52 3

External Ids:    HGNC: 198681   Entrez Gene: 557152   Ensembl: ENSG000001251707   OMIM: 6083335   UniProtKB: Q8TEW63   

Export aliases for DOK4 gene to outside databases

Previous GC identifers: GC16M047901 GC16M057565 GC16M057240 GC16M057281 GC16M056063 GC16M043373


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DOK4 Gene: 
DOK4 (docking protein 4) is a protein-coding gene. Diseases associated with DOK4 include clear cell renal cell carcinoma, and renal cell carcinoma, and among its related super-pathways are Development GDNF family signaling. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and
plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream
effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by
T-cells

Gene Wiki entry for DOK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOK4 gene promoter:
         COUP-TF1   Elk-1   COUP   HNF-4alpha2   NF-kappaB   AREB6   COUP-TF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DOK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

DOK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M057505:  view genomic region     (about GC identifiers)

Start:
57,505,863 bp from pter      End:
57,521,239 bp from pter
Size:
15,377 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6 (See protein sequence)
Recommended Name: Docking protein 4  
Size: 326 amino acids; 37028 Da
Subunit: Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires
phosphorylation of RET 'Tyr-1062' (By similarity)
Sequence caution: Sequence=AAC24310.1; Type=Erroneous gene model prediction;
Secondary accessions: O75209 Q9BTP2 Q9NVV3

Explore the universe of human proteins at neXtProt for DOK4: NX_Q8TEW6

Explore proteomics data for DOK4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TEW6

  • DOK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOK4 Protein Expression
    REFSEQ proteins: NP_060580.2  
    ENSEMBL proteins: 
     ENSP00000455566   ENSP00000344277   ENSP00000455128   ENSP00000457971   ENSP00000456864  
     ENSP00000456590   ENSP00000458037   ENSP00000457621   ENSP00000457192   ENSP00000457730  
     ENSP00000457670   ENSP00000457212   ENSP00000456739   ENSP00000454738   ENSP00000457188  
     ENSP00000455528  

    Human Recombinant Protein Products for DOK4: 
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    Novus Biologicals DOK4 Protein
    Novus Biologicals DOK4 Lysate
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for DOK4 


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    Cloud-Clone Corp. CLIAs for DOK4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TEW6

    ProtoNet protein and cluster: Q8TEW6

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6
    Domain: PTB domain mediates receptor interaction (By similarity)
    Similarity: Belongs to the DOK family. Type B subfamily
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    DOK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK4_HUMAN, Q8TEW6
    Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
    for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and
    plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream
    effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by
    T-cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI16273093
    GO:0005543phospholipid binding IEA--
         
    DOK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DOK4:
     Decreased Salmonella enterica  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOK4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOK4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOK4 
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    miRNA
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    hsa-miR-140-5p hsa-miR-520f hsa-miR-3194-5p hsa-miR-3651 hsa-miR-765 hsa-miR-766 hsa-miR-4267 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidDOK4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DOK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    GDNF-Family Ligands and Receptor Interactions0.41
    2Signaling events regulated by Ret tyrosine kinase
    Signaling events regulated by Ret tyrosine kinase

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DOK4
        GDNF-Family Ligands and Receptor Interactions

    1 BioSystems Pathway for DOK4
        Signaling events regulated by Ret tyrosine kinase


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DOK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for DOK4 (Q8TEW62, 3 ENSP000003442774) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74514 MINT-74515 I2D: score=2 STRING: ENSP00000269571
    EGFRP005332, 3, ENSP000002754934MINT-74513 I2D: score=2 STRING: ENSP00000275493
    TEKQ027633, ENSP000003839774I2D: score=2 STRING: ENSP00000383977
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0007399nervous system development IEA--

    DOK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DOK4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOK4

    1 Novoseek inferred chemical compound relationship for DOK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37 9 14963042 (5), 17258175 (2), 15855164 (1)

    Search CenterWatch for drugs/clinical trials and news about DOK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOK4 gene: 
    NM_018110.3  

    Unigene Cluster for DOK4:

    Docking protein 4
    Hs.279832  [show with all ESTs]
    Unigene Representative Sequence: NM_018110
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566936(uc010cdb.3) ENST00000340099(uc002elv.4) ENST00000569548
    ENST00000569010 ENST00000561659 ENST00000561918 ENST00000569250 ENST00000564378
    ENST00000562737 ENST00000568617 ENST00000567276 ENST00000566588 ENST00000567214
    ENST00000569538 ENST00000563483 ENST00000566705 ENST00000562008 ENST00000567175

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate DOK4 (see all 39):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-3194-5p hsa-miR-3651 hsa-miR-765 hsa-miR-766 hsa-miR-4267 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidDOK4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOK4

    Additional mRNA sequence: 

    AF466369.1 AK001350.1 AK307270.1 AK315426.1 BC001540.2 BC003541.1 

    23 DOTS entries:

    DT.454003  DT.100799222  DT.419003  DT.95078452  DT.100887499  DT.100733658  DT.100887508  DT.92457515 
    DT.120657601  DT.100689281  DT.100887493  DT.100038826  DT.100673226  DT.120657587  DT.97795902  DT.100697983 
    DT.120657546  DT.120657555  DT.92457531  DT.95168012  DT.95168027  DT.120657607  DT.95168020 

    24/254 AceView cDNA sequences (see all 254):

    CR608867 CA950395 AL538247 BE295528 AA780101 BQ068645 CA430929 AA402614 
    BE313458 CB851638 BE263160 AI263163 BE383345 AL565672 BX366437 CR623999 
    BU634132 CR619149 BC003541 AA427495 AA078997 AI968180 AA973194 BM129626 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for DOK4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e ^ 12a ·
    SP1:                                                                                                  -     -                                                   
    SP2:                                                                                                        -                                                   
    SP3:                                                                                                                                                            
    SP4:                    -     -     -     -     -     -     -     -     -     -     -                 -     -                                                   
    SP5:                          -     -     -     -     -     -     -     -     -     -                 -     -                                                   

    ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DOK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOK4 expression in normal human tissues (normalized intensities)      DOK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAGATTA
    DOK4 Expression
    About this image


    DOK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             ganglion/cranial/facial VII   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiomyocyte-like progenitor cells ( Derivation of cardiomyocytes from pluripotent...
     
     Colon (Gastrointestinal Tract)
             distal colon   
     
     Intestine (Gastrointestinal Tract)
             ileum   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See DOK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOK4

    SOURCE GeneReport for Unigene cluster: Hs.279832

    UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6
    Tissue specificity: Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker
    expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated
    peripheral blood T-cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DOK4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dok41 , 5 docking protein 41, 5 91.28(n)1
    98.46(a)1
      8 (46.93 cM)5
    1142551  NM_053246.31  NP_444476.11 
     948638285 
    chicken
    (Gallus gallus)
    Aves LOC4306101 docking protein 4-like 83.61(n)
    90.1(a)
      430610  XM_003641888.1  XP_003641936.1 
    lizard
    (Anolis carolinensis)
    Reptilia DOK46
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343677.1(26356-39812)
    African clawed frog
    (Xenopus laevis)
    Amphibia dok4-prov2 downstream of tyrosine kinase 4 74.66(n)    BC044121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5689121 docking protein 4-like 72.61(n)
    80.86(a)
      568912  XM_692273.2  XP_697365.2 


    ENSEMBL Gene Tree for DOK4 (if available)
    TreeFam Gene Tree for DOK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOK4 gene
    DOK62  DOK12  DOK32  DOK22  DOK52  
    3 SIMAP similar genes for DOK4 using alignment to 12 protein entries:     DOK4_HUMAN (see all proteins):
    DOK6    DOK5    FRS2

    DOK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/352 SNPs in DOK4 are shown (see all 352)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838680251,2
    --57506464(+) AGAGGA/GGGGCA 1 -- ut310--------
    rs1890378061,2
    --57506620(+) AGGAGC/GCTGTG 1 -- ut310--------
    rs1920382651,2
    --57506656(+) TTTCAC/TCTGAG 1 -- ut310--------
    rs794244841,2
    C,F--57506729(+) GAAGTG/ACAGAT 1 -- ut311Minor allele frequency- A:0.08EA 120
    rs1848539991,2
    --57506736(+) AGATCC/TTTCCT 1 -- ut310--------
    rs1140239191,2
    C--57506800(+) GGCTGC/TCTGGG 1 -- ut310--------
    rs1844011,2
    C,F,A,H--57506801(+) GCTGTT/CTGGGA 1 -- ut31 ese329Minor allele frequency- C:0.23MN NA NS EA WA CSA 2664
    rs2238751,2
    C,F,H--57506915(+) ATGGAC/TACGAC 1 -- ut31 ese321Minor allele frequency- T:0.14MN NS EA NA CSA WA 2577
    rs1822141511,2
    --57506978(+) AATTTG/TTGTGT 1 -- ut310--------
    rs1407720051,2
    --57506999(+) AAGGAC/TGGGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DOK4 (57505863 - 57521239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DOK4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906726CNV Loss21882294
    nsv906724CNV Loss21882294
    nsv833245CNV Loss17160897
    nsv906725CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608333    OMIM disorders: --

    5 diseases for DOK4:    About MalaCards
    clear cell renal cell carcinoma    renal cell carcinoma    lung cancer    endotheliitis
    neuronitis


    DOK4 for disorders           About GeneDecksing


    Export disorders for DOK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOK4 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DOK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2, 3 Loftus B.J.... Adams M.D. (1999)
    2. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)1, 2, 9 Favre C....Nunes J.A. (2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. (PubMed id 12730241)1, 2 Cai D.... Shoelson S.E. (2003)
    6. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    7. New insights into Dok-4 PTB domain structure and funct ion. (PubMed id 22982678)1 Hooker E....Lemay S. (2012)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Dok-4 is a novel negative regulator of T cell activat ion. (PubMed id 19494292)1 GAcrard A....NunA"s J.A. (2009)
    10. Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. (PubMed id 19073520)1 Gray S.G....O'Byrne K.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55715 HGNC: 19868 AceView: DOK4 Ensembl:ENSG00000125170 euGenes: HUgn55715
    ECgene: DOK4 H-InvDB: DOK4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOK4 gene:
    Search GeneIP for patents involving DOK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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