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DOK4 Gene

protein-coding   GIFtS: 54
GCID: GC16M057505

Docking Protein 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Docking Protein 41 2
Downstream Of Tyrosine Kinase 42 3
Insulin Receptor Substrate 52 3
IRS-52 3
IRS52 3

External Ids:    HGNC: 198681   Entrez Gene: 557152   Ensembl: ENSG000001251707   OMIM: 6083335   UniProtKB: Q8TEW63   

Export aliases for DOK4 gene to outside databases

Previous GC identifers: GC16M047901 GC16M057565 GC16M057240 GC16M057281 GC16M056063 GC16M043373


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DOK4 Gene:
DOK4 (docking protein 4) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and
plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream
effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by
T-cells

Gene Wiki entry for DOK4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOK4 gene promoter:
         COUP-TF1   Elk-1   COUP   HNF-4alpha2   NF-kappaB   AREB6   COUP-TF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DOK4 promoter sequence
   Search Chromatin IP Primers for DOK4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q13

DOK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M057505:  view genomic region     (about GC identifiers)

Start:
57,505,863 bp from pter      End:
57,521,239 bp from pter
Size:
15,377 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6 (See protein sequence)
Recommended Name: Docking protein 4  
Size: 326 amino acids; 37028 Da
Subunit: Interacts with RET and TEK/TIE2. Interaction with RET is mediated through the PTB domain and requires
phosphorylation of RET 'Tyr-1062' (By similarity)
Sequence caution: Sequence=AAC24310.1; Type=Erroneous gene model prediction;
Secondary accessions: O75209 Q9BTP2 Q9NVV3

Explore the universe of human proteins at neXtProt for DOK4: NX_Q8TEW6

Explore proteomics data for DOK4 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues in response to insulin, IGF1 or RET stimulation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOK4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060580.2  
    ENSEMBL proteins: 
     ENSP00000455566   ENSP00000344277   ENSP00000455128   ENSP00000457971   ENSP00000456864  
     ENSP00000456590   ENSP00000458037   ENSP00000457621   ENSP00000457192   ENSP00000457730  
     ENSP00000457670   ENSP00000457212   ENSP00000456739   ENSP00000454738   ENSP00000457188  
     ENSP00000455528  

    DOK4 Human Recombinant Protein Products:

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    Novus Biologicals DOK4 Protein
    Novus Biologicals DOK4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOK4

     
    Search eBioscience for Proteins for DOK4 

     
    antibodies-online proteins for DOK4 

     
    antibodies-online peptides for DOK4

    DOK4 Antibody Products:

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    antibodies-online antibodies for DOK4 (46 products) 

    DOK4 Assay Products:

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    Cloud-Clone Corp. ELISAs for DOK4
    Cloud-Clone Corp. CLIAs for DOK4
    Search eBioscience for ELISAs for DOK4 
    antibodies-online kits for DOK4 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TEW6

    ProtoNet protein and cluster: Q8TEW6

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6
    Domain: PTB domain mediates receptor interaction (By similarity)
    Similarity: Belongs to the DOK family. Type B subfamily
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    Find genes that share domains with DOK4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK4_HUMAN, Q8TEW6
    Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
    for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and
    plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream
    effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by
    T-cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI16273093
         
    Find genes that share ontologies with DOK4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DOK4:
     Decreased Salmonella enterica  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DOK4

    miRNA
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    miRTarBase miRNAs that target DOK4:
    hsa-mir-421 (MIRT039377)

    Block miRNA regulation of human, mouse, rat DOK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOK4 (see all 39):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-3194-5p hsa-miR-3651 hsa-miR-765 hsa-miR-766 hsa-miR-4267 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidDOK4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DOK4
    Predesigned siRNA for gene silencing in human, mouse, rat DOK4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DOK4 (NM_018110)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    extracellular1
    mitochondrion1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOK4 About    
    See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    GDNF-Family Ligands and Receptor Interactions0.41
    2Signaling events regulated by Ret tyrosine kinase
    Signaling events regulated by Ret tyrosine kinase

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DOK4
        GDNF-Family Ligands and Receptor Interactions

    1 BioSystems Pathway for DOK4
        Signaling events regulated by Ret tyrosine kinase


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOK4
    Interactions:

        GeneGlobe Interaction Network for DOK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for DOK4 (Q8TEW61, 2, 3 ENSP000003442774) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046261, 2, 3, ENSP000002695714EBI-6918542,EBI-641062 MINT-74514 MINT-74515 I2D: score=2 STRING: ENSP00000269571
    EGFRP005332, 3, ENSP000002754934MINT-74513 I2D: score=2 STRING: ENSP00000275493
    TEKQ027633, ENSP000003839774I2D: score=2 STRING: ENSP00000383977
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IEA--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0007399nervous system development IEA--

    Find genes that share ontologies with DOK4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOK4

    1 Novoseek inferred chemical compound relationship for DOK4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 37 9 14963042 (5), 17258175 (2), 15855164 (1)



    Find genes that share compounds with DOK4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DOK4 gene: 
    NM_018110.3  

    Unigene Cluster for DOK4:

    Docking protein 4
    Hs.279832  [show with all ESTs]
    Unigene Representative Sequence: NM_018110
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000566936(uc010cdb.3) ENST00000340099(uc002elv.4) ENST00000569548
    ENST00000569010 ENST00000561659 ENST00000561918 ENST00000569250 ENST00000564378
    ENST00000562737 ENST00000568617 ENST00000567276 ENST00000566588 ENST00000567214
    ENST00000569538 ENST00000563483 ENST00000566705 ENST00000562008 ENST00000567175

    miRNA
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    Block miRNA regulation of human, mouse, rat DOK4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOK4 (see all 39):
    hsa-miR-140-5p hsa-miR-520f hsa-miR-3194-5p hsa-miR-3651 hsa-miR-765 hsa-miR-766 hsa-miR-4267 hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmidDOK4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DOK4
    Predesigned siRNA for gene silencing in human, mouse, rat DOK4
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK4
    Primer
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    OriGene qPCR primer pairs and template standards for DOK4
    OriGene qSTAR qPCR primer pairs in human, mouse for DOK4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOK4
      QuantiTect SYBR Green Assays in human, mouse, rat DOK4
      QuantiFast Probe-based Assays in human, mouse, rat DOK4

    Additional mRNA sequence: 

    AF466369.1 AK001350.1 AK307270.1 AK315426.1 BC001540.2 BC003541.1 

    23 DOTS entries:

    DT.454003  DT.100799222  DT.419003  DT.95078452  DT.100887499  DT.100733658  DT.100887508  DT.92457515 
    DT.120657601  DT.100689281  DT.100887493  DT.100038826  DT.100673226  DT.120657587  DT.97795902  DT.100697983 
    DT.120657546  DT.120657555  DT.92457531  DT.95168012  DT.95168027  DT.120657607  DT.95168020 

    Selected AceView cDNA sequences (see all 254):

    AI968180 BX451652 BM817907 BU633999 BX366437 AV655455 BE295528 BF316380 
    AI766552 F03011 BE261069 CB250416 AA780101 BF591163 BE313458 BM852745 
    BE263160 AI263163 CA950635 AI214207 CA430929 CA950508 BX331429 BC003541 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DOK4 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e ^ 12a ·
    SP1:                                                                                                  -     -                                                   
    SP2:                                                                                                        -                                                   
    SP3:                                                                                                                                                            
    SP4:                    -     -     -     -     -     -     -     -     -     -     -                 -     -                                                   
    SP5:                          -     -     -     -     -     -     -     -     -     -                 -     -                                                   

    ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DOK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOK4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAGATTA
    DOK4 Expression
    About this image


    DOK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Endocardial Tube Cells Endocardium
             Cardiomyocyte-like progenitor cells
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     NULL (Uncategorized)
             DKK1-induced cells
     
     Colon (Gastrointestinal Tract)
    DOK4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOK4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279832

    UniProtKB/Swiss-Prot: DOK4_HUMAN, Q8TEW6
    Tissue specificity: Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker
    expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated
    peripheral blood T-cells

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    QuantiFast Probe-based Assays in human, mouse, rat DOK4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DOK4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dok41 , 5 docking protein 41, 5 91.28(n)1
    98.46(a)1
      8 (46.93 cM)5
    1142551  NM_053246.31  NP_444476.11 
     948638285 
    chicken
    (Gallus gallus)
    Aves DOK41 docking protein 4 83.61(n)
    90.1(a)
      430610  XM_003641888.2  XP_003641936.1 
    lizard
    (Anolis carolinensis)
    Reptilia DOK46
    docking protein 4
    92(a)
    1 ↔ 1
    GL343677.1(26356-39812)
    African clawed frog
    (Xenopus laevis)
    Amphibia dok4-prov2 downstream of tyrosine kinase 4 74.66(n)    BC044121.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5689121 docking protein 4-like 72.61(n)
    80.86(a)
      568912  XM_692273.3  XP_697365.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dok6
    Downstream of kinase
    10(a)
    1 → many
    X(7218251-7222839)


    ENSEMBL Gene Tree for DOK4 (if available)
    TreeFam Gene Tree for DOK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOK4 gene
    DOK62  DOK12  DOK32  DOK22  DOK52  
    3 SIMAP similar genes for DOK4 using alignment to 12 protein entries:     DOK4_HUMAN (see all proteins):
    DOK6    DOK5    FRS2

    Find genes that share paralogs with DOK4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOK4 (see all 352)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838680251,2
    --57506464(+) AGAGGA/GGGGCA 1 -- ut310--------
    rs1890378061,2
    --57506620(+) AGGAGC/GCTGTG 1 -- ut310--------
    rs1920382651,2
    --57506656(+) TTTCAC/TCTGAG 1 -- ut310--------
    rs794244841,2
    C,F--57506729(+) GAAGTG/ACAGAT 1 -- ut311Minor allele frequency- A:0.08EA 120
    rs1848539991,2
    --57506736(+) AGATCC/TTTCCT 1 -- ut310--------
    rs1140239191,2
    C--57506800(+) GGCTGC/TCTGGG 1 -- ut310--------
    rs1844011,2
    C,F,A,H--57506801(+) GCTGTT/CTGGGA 1 -- ut31 ese329Minor allele frequency- C:0.23MN NA NS EA WA CSA 2664
    rs2238751,2
    C,F,H--57506915(+) ATGGAC/TACGAC 1 -- ut31 ese321Minor allele frequency- T:0.14MN NS EA NA CSA WA 2577
    rs1822141511,2
    --57506978(+) AATTTG/TTGTGT 1 -- ut310--------
    rs1407720051,2
    --57506999(+) AAGGAC/TGGGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DOK4 (57505863 - 57521239 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DOK4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906726CNV Loss21882294
    nsv906724CNV Loss21882294
    nsv833245CNV Loss17160897
    nsv906725CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOK4
    DNA2.0 Custom Variant and Variant Library Synthesis for DOK4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608333    OMIM disorders: --


    Find genes that share disorders with DOK4           About GenesLikeMe


    Export disorders for DOK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOK4 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with DOK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2, 3 Loftus B.J.... Adams M.D. (Genomics 1999)
    2. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)1, 2, 9 Favre C.... Nunes J.A. (Genes Immun. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. (PubMed id 12730241)1, 2 Cai D.... Shoelson S.E. (J. Biol. Chem. 2003)
    6. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    7. New insights into Dok-4 PTB domain structure and function. (PubMed id 22982678)1 Hooker E....Lemay S. (Biochem. Biophys. Res. Commun. 2012)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. Dok-4 is a novel negative regulator of T cell activation. (PubMed id 19494292)1 GAcrard A....NunA"s J.A. (J. Immunol. 2009)
    10. Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells. (PubMed id 19073520)1 Gray S.G....O'Byrne K.J. (Clin Lung Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55715 HGNC: 19868 AceView: DOK4 Ensembl:ENSG00000125170 euGenes: HUgn55715
    ECgene: DOK4 H-InvDB: DOK4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOK4 gene:
    Search GeneIP for patents involving DOK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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