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Set Analyses:

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DOK3 Gene

protein-coding GIFtS: 50
GCID: GC05M176928

Docking Protein 3

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Docking Protein 3¹ ²
Downstream Of Tyrosine Kinase 3² ³
DOKL² ⁵
Dok-Like Protein²

External Ids:	HGNC: 24583¹	Entrez Gene: 79930²	Ensembl: ENSG00000146094⁷	OMIM: 611435⁵	UniProtKB: Q7L591³

Export aliases for DOK3 gene to outside databases

Previous GC identifers: GC00U916977 GC05M176861 GC05M171849

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DOK3 Gene:

DOK3 (docking protein 3) is a protein-coding gene. Diseases associated with DOK3 include inflammatory bowel disease, and neuronitis. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591

Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform

for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells

through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)

Gene Wiki entry for DOK3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the DOK3 gene promoter:
E2F AP-1 STAT3 IRF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOK3 promoter sequence

Search Chromatin IP Primers for DOK3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35

DOK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M176928: view genomic region (about GC identifiers)

Start:	176,928,905 bp from pter	End:	176,938,275 bp from pter
Size:	9,371 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591 (See protein sequence)

Recommended Name: Docking protein 3

Size: 496 amino acids; 53288 Da

Subunit: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and

Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1

through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity)

Secondary accessions: E9PAT0 H7BXS0 Q8N864 Q9BQB3 Q9H666

Alternative splicing: 4 isoforms: Q7L591-1 Q7L591-2 Q7L591-3 Q7L591-4 (No experimental confirmation available. Ref.1 (BAC04986) sequence is in conflict in position: 200:R->C)

Explore the universe of human proteins at neXtProt for DOK3: NX_Q7L591

Explore proteomics data for DOK3 at MOPED

Post-translational modifications:

Constitutively tyrosine-phosphorylated (By similarity)¹

On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be

phosphorylated by ABL1 kinase (By similarity)¹

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See DOK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001138347.1 NP_001138348.1 NP_079148.2

ENSEMBL proteins:

ENSP00000325174 ENSP00000366316 ENSP00000349727 ENSP00000421688 ENSP00000422395

ENSP00000423328 ENSP00000423635 ENSP00000424726 ENSP00000424580 ENSP00000426694

DOK3 Human Recombinant Protein Products:

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	Novus Biologicals DOK3 Protein Novus Biologicals DOK3 Lysate
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	Cloud-Clone Corp. Proteins for DOK3

DOK3 Antibody Products:

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	Novus Biologicals DOK3 Antibodies
	Abcam antibodies for DOK3
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	ThermoFisher Antibodies for DOK3
	LSBio Antibodies in human, mouse, rat for DOK3

DOK3 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for DOK3
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DOK3 Cloud-Clone Corp. CLIAs for DOK3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR002404 Insln_rcpt_S1

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q7L591

ProtoNet protein and cluster: Q7L591

1 Blocks protein domain: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591

Domain: PTB domain mediates receptor interaction (By similarity)

Similarity: Belongs to the DOK family. Type A subfamily

Similarity: Contains 1 IRS-type PTB domain

Similarity: Contains 1 PH domain

DOK3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DOK3_HUMAN, Q7L591

Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform

for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells

through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005158	insulin receptor binding	IEA	--
GO:0005515	protein binding	IPI	17290227

DOK3 for ontologies About GeneDecksing

Phenotypes:
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dok3):

hematopoietic system

immune system

mortality/aging

respiratory system

tumorigenesis

DOK3 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Dok3^tm1Ppp for DOK3

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOK3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOK3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOK3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOK3

miRNA Products:		miRTarBase miRNAs that target DOK3: hsa-mir-320a (MIRT044507)

		Block miRNA regulation of human, mouse, rat DOK3 using miScript Target Protectors
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		SwitchGear 3'UTR luciferase reporter plasmid: DOK3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DOK3
		Predesigned siRNA for gene silencing in human, mouse, rat DOK3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DOK3

Clone Products:		OriGene clones in human, mouse for DOK3 (see all 17) OriGene ORF clones in mouse, rat for DOK3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): DOK3 (NM_024872)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOK3
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DOK3
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DOK3_HUMAN, Q7L591: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By

similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5
nucleus	2
cytosol	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--

DOK3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for DOK3 About

See pathways by source

SuperPath

Contained pathways About

B Cell Receptor Signaling Pathway (WikiPathways)

B Cell Receptor Signaling Pathway

1 BioSystems Pathway for DOK3

B Cell Receptor Signaling Pathway

Pathway & Disease-focused RT² Profiler PCR Array including DOK3:

Insulin Signaling Pathway in human mouse rat

Interactions:

GeneGlobe Interaction Network for DOK3

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for DOK3 (Q7L591^{1, 2, 3} ENSP00000349727⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
INPP5D	Q92835²^,³, ENSP00000352575⁴	MINT-4329711 I2D: score=2 STRING: ENSP00000352575
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-8034859 MINT-8035813 MINT-8287491 I2D: score=1 STRING: ENSP00000339007
ABL1	P00519³, ENSP00000361423⁴	I2D: score=2 STRING: ENSP00000361423
CSK	P41240³, ENSP00000220003⁴	I2D: score=1 STRING: ENSP00000220003
FYN	P06241³, ENSP00000357656⁴	I2D: score=1 STRING: ENSP00000357656

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007265	Ras protein signal transduction	IEA	--

DOK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DOK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DOK3 gene (3 alternative transcripts):

NM_001144875.1 NM_001144876.1 NM_024872.2

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000312943(uc003mhi.4 uc003mhj.4) ENST00000500323(uc003mhh.4)

ENST00000377112 ENST00000357198(uc003mhk.3) ENST00000501403 ENST00000510380

ENST00000506493 ENST00000502885 ENST00000510898 ENST00000509310 ENST00000502380

ENST00000512660 ENST00000510389

miRNA Products:		Block miRNA regulation of human, mouse, rat DOK3 using miScript Target Protectors
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		SwitchGear 3'UTR luciferase reporter plasmid: DOK3 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DOK3
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Clone Products:		OriGene clones in human, mouse for DOK3 (see all 17) OriGene ORF clones in mouse, rat for DOK3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): DOK3 (NM_024872)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK3

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DOK3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DOK3
		QuantiTect SYBR Green Assays in human, mouse, rat DOK3
		QuantiFast Probe-based Assays in human, mouse, rat DOK3

Selected AceView cDNA sequences (see all 120):

BF795410 BM479812 CD367823 CR595723 AA765866 BG756981 BQ030365 BG754710

AK097258 BF477398 BV175653 AL583057 BQ061745 BQ422792 BG755871 BU158395

BQ436982 BX364341 BX337814 BM457606 BQ061336 BI489608 BG546489 BI518837

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DOK3 (see all 13) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	·	3d	·	3e	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b
SP1:			-		-		-		-		-		-		-				-		-		-												-		-
SP2:			-		-		-		-		-								-		-		-												-		-
SP3:											-								-		-		-
SP4:			-		-		-		-		-								-		-		-		-		-								-		-
SP5:											-		-		-				-		-		-

ECgene alternative splicing isoforms for DOK3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DOK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

DOK3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DOK3 Protein Expression

UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591

Tissue specificity: Expressed in spleen

Pathway & Disease-focused RT² Profiler PCR Array including DOK3:

Insulin Signaling Pathway in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DOK3
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DOK3
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DOK3 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dok3^{1 , 5}	docking protein 3^{1, 5}	79.77(n)¹ 78.41(a)¹		13 (30.06 cM)⁵ 27261¹ NM_013739.2¹ NP_038767.1¹ 55523235⁵
chicken (Gallus gallus)	Aves	DOK3¹	docking protein 3	60.02(n) 48.13(a)		429960 NM_001083363.1 NP_001076832.1
lizard (Anolis carolinensis)	Reptilia	DOK3⁶	docking protein 3	40(a)	1 ↔ 1	2(145622370-145637992)
zebrafish (Danio rerio)	Actinopterygii	CABZ01072950.1⁶	Uncharacterized protein	42(a)	1 ↔ 1	14(51981054-51997702) ENSDARG00000086910
fruit fly (Drosophila melanogaster)	Insecta	Dok⁶	Downstream of kinase	13(a)	1 → many	X(7218251-7222839)

ENSEMBL Gene Tree for DOK3 (if available)
TreeFam Gene Tree for DOK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DOK3 gene

DOK6² DOK1² DOK4² DOK2² DOK5²

2 SIMAP similar genes for DOK3 using alignment to 8 protein entries: DOK3_HUMAN (see all proteins):

FRS2 DOK1

DOK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111786724^1,2	C,F	--	176928454(+)	`GCCTCT/ATGGCC`	2	--	int¹		2		CSA WA	119
rs34440308^1,2	C,F	--	176928514(-)	`ATTTCG/AGCTCA`	2	--	int¹		2		NA	122
rs28587302^1,2	C	--	176928515(+)	`GAGCCG/AAAATC`	2	--	int¹		12		WA NA CSA EA	374
rs180670688^1,2		--	176928719(+)	`ACAGAC/GCTTCG`	2	--	int¹		0	--	--	--	--
rs55643106^1,2	C,F	--	176928835(+)	`TGAGCG/ATGGAT`	2	--	int¹		2		WA	120
rs185104857^1,2		--	176928840(+)	`GTGGAC/TGCCCA`	2	--	int¹		0	--	--	--	--
rs189183288^1,2		--	176928841(+)	`TGGATA/GCCCAG`	2	--	int¹		0	--	--	--	--
rs143828793^1,2		--	176928862(+)	`CCAGAC/TTGATG`	2	--	int¹		0	--	--	--	--
rs28446242^1,2	C,F,H	--	176929080(+)	`ATTGTT/CATGAG`	2	--	ut3¹		5		EA NS NA	512
rs1422268^1,2	C,F,O,H	--	176929130(-)	`CACTCA/GGCTCT`	2	--	ut3¹ ese³		17		MN NS EA NA WA CSA	978

HapMap Linkage Disequilibrium report for DOK3 (176928905 - 176938275 bp)

Structural Variations
Database of Genomic Variants (DGV) 6 variations for DOK3: About this table

Variant ID	Type	Subtype	PubMed ID
dgv6379n71	CNV	Loss	21882294
nsv883180	CNV	Loss	21882294
nsv883177	CNV	Loss	21882294
dgv6383n71	CNV	Loss	21882294
dgv6381n71	CNV	Loss	21882294
nsv883164	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing DOK3

DNA2.0 Custom Variant and Variant Library Synthesis for DOK3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611435 OMIM disorders: --

2 diseases for DOK3:
About MalaCards

inflammatory bowel disease neuronitis

DOK3 for disorders About GeneDecksing

Export disorders for DOK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DOK3 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with DOK3)

Utopia: connect your pdf to the dynamic
world of online information

DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)^{1, 2, 3} Favre C.... Nunes J.A. (Genes Immun. 2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. (PubMed id 10733577)^{1, 3} Lemay S....Veillette A. (Mol. Cell. Biol. 2000)
Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PubMed id 19682241)^{1, 9} Senis Y.A....GarcA-a A. (J. Thromb. Haemost. 2009)
The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters. (PubMed id 23223229)¹ LAPsing M....Engelke M. (J. Biol. Chem. 2013)
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)¹ Jostins L....Cho J.H. (Nature 2012)
DOK3 negatively regulates LPS responses and endotoxin tolerance. (PubMed id 22761938)¹ Peng Q....Humphrey M.B. (PLoS ONE 2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. (PubMed id 21822214)¹ Oellerich T....Wienands J. (EMBO J. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79930	HGNC: 24583	AceView: DOK3	Ensembl:ENSG00000146094	euGenes: HUgn79930
ECgene: DOK3	H-InvDB: DOK3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DOK3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DOK3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DOK3 gene:
Search GeneIP for patents involving DOK3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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