Aliases for DOK3 Gene
Aliases for DOK3 Gene
External Ids for DOK3 Gene
- HGNC: 24583
- Entrez Gene: 79930
- Ensembl: ENSG00000146094
- OMIM: 611435
- UniProtKB: Q7L591
Previous GeneCards Identifiers for DOK3 Gene
- GC00U916977
- GC05M176861
- GC05M176928
- GC05M171849
Summaries for DOK3 Gene
GeneCards Summary for DOK3 Gene
DOK3 (Docking Protein 3) is a Protein Coding gene. Among its related pathways are Innate Immune System and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK2.
UniProtKB/Swiss-Prot for DOK3 Gene
-
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK3 Gene
Genomics for DOK3 Gene
GeneHancer (GH) Regulatory Elements for DOK3 Gene
Regulatory Element Products
Genomic Locations for DOK3 Gene
- chr5:177,501,904-177,511,274
- (GRCh38/hg38)
- Size:
- 9,371 bases
- Orientation:
- Minus strand
- chr5:176,928,905-176,938,275
- (GRCh37/hg19)
Genomic View for DOK3 Gene
- Cytogenetic band:
-
- 5q35.3 by Ensembl
- 5q35.3 by Entrez Gene
- 5q35.3 by HGNC


RefSeq DNA sequence for DOK3 Gene
Proteins for DOK3 Gene
-
Protein details for DOK3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q7L591-DOK3_HUMAN
- Recommended name:
- Docking protein 3
- Protein Accession:
- Q7L591
- E9PAT0
- H7BXS0
- Q8N864
- Q9BQB3
- Q9H666
Protein attributes for DOK3 Gene
- Size:
- 496 amino acids
- Molecular mass:
- 53288 Da
- Quaternary structure:
-
- On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).
Protein Expression for DOK3 Gene
Post-translational modifications for DOK3 Gene
- Constitutively tyrosine-phosphorylated.
- On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
Other Protein References for DOK3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DOK3 (DOK3)
-
Custom Antibody ServicesOriGene Antibodies for DOK3
- Novus Biologicals Antibodies for DOK3
-
Abcam antibodies for DOK3
-
Cloud-Clone Corp. Antibodies for DOK3
- Invitrogen Antibodies for DOK3
- GeneTex DOK3 antibody for DOK3
-
Santa Cruz Biotechnology (SCBT) Antibodies for DOK3
Protein Products
-
OriGene Purified Proteins for DOK3
- Search Origene for MassSpec and Protein Over-expression Lysates for DOK3
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-
Cloud-Clone Corp. Proteins for DOK3
- Search GeneTex for Proteins for DOK3
-
Abcam proteins for DOK3
Assay Products
- antibodies-online: Search results for available DOK3 related products ranked by validation data
No data available for DME Specific Peptides for DOK3 Gene
Domains & Families for DOK3 Gene
Gene Families for DOK3 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for DOK3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DOK3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q7L591UniProtKB/Swiss-Prot:
DOK3_HUMAN :- PTB domain mediates receptor interaction.
- Belongs to the DOK family. Type A subfamily.
- Domain:
-
- PTB domain mediates receptor interaction.
- Family:
-
- Belongs to the DOK family. Type A subfamily.
Function for DOK3 Gene
Molecular function for DOK3 Gene
- UniProtKB/Swiss-Prot Function:
- DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).
Phenotypes From GWAS Catalog for DOK3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 17290227 |
Phenotypes for DOK3 Gene
- MGI mutant phenotypes for DOK3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DOK3:
Animal Models for DOK3 Gene
- MGI Knock Outs for DOK3:
-
- Dok3 tm1Ppp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DOK3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DOK3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DOK3 gene
- Search ViGene Biosciences for DOK3
CRISPR Products
-
OriGene CRISPR knockouts for DOK3
- genomics-online: gRNA clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
- Applied Biological Materials CRISPR for DOK3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOK3
- GenScript: Design CRISPR guide RNA sequences for DOK3
miRNA for DOK3 Gene
- miRTarBase miRNAs that target DOK3
miRNA Products
- Search ViGene Biosciences for DOK3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DOK3
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- genomics-online: shRNA clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DOK3 gene
Clone Products
-
OriGene ORF clones in human for DOK3
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DOK3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DOK3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DOK3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DOK3
-
ViGene Biosciences adenoviral particle packaged cDNA for DOK3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DOK3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DOK3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK3 Gene
Localization for DOK3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DOK3 Gene
- Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0030667 | secretory granule membrane | TAS | -- |
GO:0101003 | ficolin-1-rich granule membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DOK3 Gene
Pathways & Interactions for DOK3 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | B Cell Receptor Signaling Pathway (sino) |
Pathways by source for DOK3 Gene
1 Sino Biological pathway for DOK3 Gene
3 Reactome pathways for DOK3 Gene
Interacting Proteins for DOK3 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for DOK3 Gene
Transcripts for DOK3 Gene
mRNA/cDNA for DOK3 Gene
- (13) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (120) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for DOK3
- genomics-online: gRNA clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
- Applied Biological Materials CRISPR for DOK3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOK3
- GenScript: Design CRISPR guide RNA sequences for DOK3
miRNA Products
- Search ViGene Biosciences for DOK3
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for DOK3
- Browse OriGene Inhibitory RNA Products For DOK3
- genomics-online: shRNA clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for DOK3 gene
Clone Products
-
OriGene ORF clones in human for DOK3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DOK3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DOK3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DOK3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for DOK3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP10: | - | - | |||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP13: |
Expression for DOK3 Gene
mRNA differential expression in normal tissues according to GTEx for DOK3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOK3 Gene
NURSA nuclear receptor signaling pathways regulating expression of DOK3 Gene:
DOK3SOURCE GeneReport for Unigene cluster for DOK3 Gene:
Hs.720849mRNA Expression by UniProt/SwissProt for DOK3 Gene:
Q7L591-DOK3_HUMANEvidence on tissue expression from TISSUES for DOK3 Gene
- Blood(4.6)
- Intestine(4.3)
- Liver(4.1)
Primer Products
-
OriGene qPCR primer pairs for DOK3
- genomics-online: primer clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOK3 Gene
Orthologs for DOK3 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
dog (Canis familiaris) |
Mammalia | DOK3 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | DOK3 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Dok3 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Dok3 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | DOK3 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | DOK3 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | DOK3 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | DOK3 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | CABZ01072950.1 34 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | Dok 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4936 34 |
|
OneToMany |
- Species where no ortholog for DOK3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DOK3 Gene
(2) SIMAP similar genes for DOK3 Gene using alignment to 8 proteins:
Variants for DOK3 Gene
SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs869312828 | risk-factor, Myeloproliferative/lymphoproliferative neoplasms, familial (multiple types), susceptibility to | 177,512,369(-) | C/T | upstream_transcript_variant | |
rs78923296 | likely-benign, not specified | 177,511,717(-) | G/A | upstream_transcript_variant | |
rs140652745 | benign, not specified | 177,512,145(-) | G/A | upstream_transcript_variant | |
rs1000621375 | -- | 177,507,446(-) | C/T | intron_variant | |
rs1001407768 | -- | 177,508,708(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1161311 | CNV | duplication | 26073780 |
Additional Variant Information for DOK3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DOK3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK3 Gene
Disorders for DOK3 Gene
Additional Disease Information for DOK3
No disorders were found for DOK3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK3 Gene
Publications for DOK3 Gene
- DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C … Nunès JA (Genes and immunity 2003) 2 3 4 58
- Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PMID: 19682241) Senis YA … García A (Journal of thrombosis and haemostasis : JTH 2009) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. (PMID: 10733577) Lemay S … Veillette A (Molecular and cellular biology 2000) 2 3 58
Products for DOK3 Gene
- R&D Systems Antibodies for DOK3 (DOK3)
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for DOK3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for DOK3
- VectorBuilder custom plasmid, inducible vectors for DOK3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DOK3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 96 available DOK3 Antibodies ranked by validation data
- Compare Top DOK3 Antibodies
- antibodies-online: Search results for available DOK3 related products ranked by validation data
- antibodies-online: Search results for 10 available DOK3 Proteins ranked by validation data
- Compare Top DOK3 Proteins
- GeneTex DOK3 antibody for DOK3
- Search GeneTex for Proteins for DOK3
- ViGene Biosciences adenoviral particle packaged cDNA for DOK3 gene
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- Search ViGene Biosciences for DOK3
- Santa Cruz Biotechnology (SCBT) Antibodies for DOK3
- Search Santa Cruz Biotechnology (SCBT) for DOK3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DOK3
- Horizon Cell Lines for DOK3
- genomics-online: cdna clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
- orf clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
- genomics-online: gRNA clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
- genomics-online: primer clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
- genomics-online: shRNA clones - Search results for 112 available DOK3 gene related products
- Overview of 112 available DOK3 gene related products
Sources for DOK3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
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