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DOK3 Gene(Protein Coding)

Docking Protein 3

GCID:
GC05M177501
GIFtS:
53
Genes Participants
UDN Logo

Aliases for DOK3 Gene

Aliases for DOK3 Gene

  • Docking Protein 3 2 3 5
  • Downstream Of Tyrosine Kinase 3 3 4
  • Dok-Like Protein 3
  • DOKL 3

External Ids for DOK3 Gene

Previous GeneCards Identifiers for DOK3 Gene

  • GC00U916977
  • GC05M176861
  • GC05M176928
  • GC05M171849

Summaries for DOK3 Gene

GeneCards Summary for DOK3 Gene

DOK3 (Docking Protein 3) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (WikiPathways). GO annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK3 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Gene Wiki entry for DOK3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK3 Gene

Genomics for DOK3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DOK3 Gene

Enhancers for DOK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DOK3 on UCSC Golden Path with GeneCards custom track

Promoters for DOK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOK3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DOK3 gene promoter:

Genomic Location for DOK3 Gene

Chromosome:
5
Start:
177,501,904 bp from pter
End:
177,511,274 bp from pter
Size:
9,371 bases
Orientation:
Minus strand

Genomic View for DOK3 Gene

Genes around DOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DOK3 Gene

Proteins for DOK3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L591-DOK3_HUMAN
    Recommended name:
    Docking protein 3
    Protein Accession:
    Q7L591
    Secondary Accessions:
    • E9PAT0
    • H7BXS0
    • Q8N864
    • Q9BQB3
    • Q9H666

    Protein attributes for DOK3 Gene

    Size:
    496 amino acids
    Molecular mass:
    53288 Da
    Quaternary structure:
    • On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).

    Alternative splice isoforms for DOK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK3 Gene

Proteomics data for DOK3 Gene at MOPED

Protein Expression for DOK3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DOK3 Gene

  • Constitutively tyrosine-phosphorylated.
  • On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DOK3

No data available for DME Specific Peptides for DOK3 Gene

Domains & Families for DOK3 Gene

Protein Domains for DOK3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DOK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L591

UniProtKB/Swiss-Prot:

DOK3_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type A subfamily.
Domain:
  • PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK3: view

No data available for Gene Families for DOK3 Gene

Function for DOK3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DOK3 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Phenotypes for DOK3 Gene

MGI mutant phenotypes for DOK3:
inferred from 2 alleles
GenomeRNAi human phenotypes for DOK3:
genes like me logo Genes that share phenotypes with DOK3: view

Animal Models for DOK3 Gene

MGI Knock Outs for DOK3:

Animal Model Products

miRNA for DOK3 Gene

miRTarBase miRNAs that target DOK3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK3 Gene

Localization for DOK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOK3 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOK3 Gene COMPARTMENTS Subcellular localization image for DOK3 gene
Compartment Confidence
plasma membrane 4
nucleus 2
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DOK3: view

Pathways & Interactions for DOK3 Gene

genes like me logo Genes that share pathways with DOK3: view

Pathways by source for DOK3 Gene

1 BioSystems pathway for DOK3 Gene

Gene Ontology (GO) - Biological Process for DOK3 Gene

None

No data available for SIGNOR curated interactions for DOK3 Gene

Drugs & Compounds for DOK3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DOK3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DOK3 Gene

(12) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(120) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOK3 Gene

Docking protein 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOK3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - - -
SP10: - -
SP11: - - - -
SP12: - - -
SP13:

Relevant External Links for DOK3 Gene

GeneLoc Exon Structure for
DOK3
ECgene alternative splicing isoforms for
DOK3

Expression for DOK3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DOK3 Gene

mRNA expression in normal human tissues for DOK3 Gene
mRNA expression by BioGPS for DOK3 GenemRNA expression by GTEx for DOK3 Gene

mRNA differential expression in normal tissues according to GTEx for DOK3 Gene

This gene is overexpressed in Whole Blood (x35.0) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for DOK3 Gene

This gene is overexpressed in Lavage (25.9), Peripheral blood mononuclear cells (17.1), Platelet (10.3), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOK3 Gene



SOURCE GeneReport for Unigene cluster for DOK3 Gene Hs.720849

mRNA Expression by UniProt/SwissProt for DOK3 Gene

Q7L591-DOK3_HUMAN
Tissue specificity: Expressed in spleen.
genes like me logo Genes that share expression patterns with DOK3: view

Protein tissue co-expression partners for DOK3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DOK3 Gene

Orthologs for DOK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia DOK3 35
  • 82.25 (n)
  • 80.79 (a)
DOK3 36
  • 79 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DOK3 35
  • 82.42 (n)
  • 80.91 (a)
DOK3 36
  • 78 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dok3 35
  • 79.77 (n)
  • 78.41 (a)
Dok3 16
Dok3 36
  • 77 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dok3 35
  • 79.24 (n)
  • 77.95 (a)
oppossum
(Monodelphis domestica)
 Mammalia DOK3 36
  • 62 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DOK3 36
  • 50 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DOK3 35
  • 60.02 (n)
  • 48.13 (a)
DOK3 36
  • 43 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DOK3 36
  • 40 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii CABZ01072950.1 36
  • 42 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta Dok 36
  • 13 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.4936 36
  • 20 (a)
 OneToMany
Species with no ortholog for DOK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK3 Gene

ENSEMBL:
Gene Tree for DOK3 (if available)
TreeFam:
Gene Tree for DOK3 (if available)

Paralogs for DOK3 Gene

Paralogs for DOK3 Gene

(2) SIMAP similar genes for DOK3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with DOK3: view

Variants for DOK3 Gene

Sequence variations from dbSNP and Humsavar for DOK3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3749728 - 177,509,818(-) CGCGC(A/C/G)TGCCC intron-variant, reference, missense, utr-variant-5-prime
rs41275297 - 177,509,645(+) CCCTC(C/T)GTCTA intron-variant, reference, missense, utr-variant-5-prime
rs2878525 -- 177,510,413(-) CTCAC(A/G)TGGTT upstream-variant-2KB, utr-variant-5-prime
rs163011 -- 177,502,518(+) GTTTC(C/T)ACTGT utr-variant-3-prime
rs179810 -- 177,504,705(-) TGACA(C/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOK3 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv6381n71 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv883177 CNV Loss 21882294
nsv883180 CNV Loss 21882294

Variation tolerance for DOK3 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DOK3 Gene

Disorders for DOK3 Gene

Relevant External Links for DOK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK3

No disorders were found for DOK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK3 Gene

Publications for DOK3 Gene

  1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C. … Nunes J.A. (Genes Immun. 2003) 2 3 4 67
  2. Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PMID: 19682241) Senis Y.A. … GarcA-a A. (J. Thromb. Haemost. 2009) 3 23
  3. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. (PMID: 10733577) Lemay S. … Veillette A. (Mol. Cell. Biol. 2000) 2 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for DOK3 Gene

Sources for DOK3 Gene

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