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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOK3 Gene

protein-coding   GIFtS: 53
GCID: GC05M176928

Docking Protein 3
  See related disease
at
MalaCards
 

Aliases
for DOK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Docking Protein 31 2
Downstream Of Tyrosine Kinase 32 3
DOKL2 5
Dok-Like Protein2

External Ids:    HGNC: 245831   Entrez Gene: 799302   Ensembl: ENSG000001460947   OMIM: 6114355   UniProtKB: Q7L5913   

Export aliases for DOK3 gene to outside databases

Previous GC identifers: GC00U916977 GC05M176861 GC05M171849


Summaries
for DOK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for DOK3 Gene: 
DOK3 (docking protein 3) is a protein-coding gene. Diseases associated with DOK3 include neuronitis. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells
through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)

Gene Wiki entry for DOK3 Gene


Genomic Views
for DOK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOK3 gene promoter:
         E2F   AP-1   STAT3   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

DOK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176928:  view genomic region     (about GC identifiers)

Start:
 176,928,905 bp from pter      End:
 176,938,275 bp from pter
Size:
 9,371 bases      Orientation:
 minus strand

Proteins
for DOK3 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591 (See protein sequence)
Recommended Name: Docking protein 3  
Size: 496 amino acids; 53288 Da
Subunit: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and
Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1
through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity)
Subcellular location: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By
similarity)
Secondary accessions: E9PAT0 H7BXS0 Q8N864 Q9BQB3 Q9H666
Alternative splicing: 4 isoforms:  Q7L591-1   Q7L591-2   Q7L591-3   Q7L591-4   (No experimental confirmation available. Ref.1 (BAC04986) sequence is in conflict in position: 200:R->C)

Explore the universe of human proteins at neXtProt for DOK3: NX_Q7L591

Explore proteomics data for DOK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Constitutively tyrosine-phosphorylated (By similarity)
  • UniProtKB: On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be
    phosphorylated by ABL1 kinase (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L591

    • DOK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOK3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138347.1  NP_001138348.1  NP_079148.2  

    ENSEMBL proteins: 
     ENSP00000325174   ENSP00000366316   ENSP00000349727   ENSP00000421688   ENSP00000422395  
     ENSP00000423328   ENSP00000423635   ENSP00000424726   ENSP00000424580   ENSP00000426694  

    Human Recombinant Protein Products for DOK3: 
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    Novus Biologicals DOK3 Protein
    Novus Biologicals DOK3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOK3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    DOK3 for ontologies           About GeneDecksing



    DOK3 Antibody Products: 
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    Abcam antibodies for DOK3
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    ThermoFisher Antibodies for DOK3
    LSBio Antibodies in human, mouse, rat for DOK3 

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    Cloud-Clone Corp. ELISAs for DOK3 
    Cloud-Clone Corp. CLIAs for DOK3

    Protein Domains /
    Families
    for DOK3 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q7L591

    ProtoNet protein and cluster: Q7L591

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591
    Domain: PTB domain mediates receptor interaction (By similarity)
    Similarity: Belongs to the DOK family. Type A subfamily
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    DOK3 for domains           About GeneDecksing


    Function
    for DOK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK3_HUMAN, Q7L591
    Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
    for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells
    through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI17290227
    GO:0005543phospholipid binding IEA--
         
    DOK3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dok3):
     hematopoietic system  immune system  mortality/aging  respiratory system  tumorigenesis 

    DOK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dok3tm1Ppp for DOK3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOK3 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOK3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DOK3
    SwitchGear 3'UTR luciferase reporter plasmid: DOK3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DOK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DOK3
    Sirion Biotech Customized adenovirus for overexpression of DOK3

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): DOK3 (NM_024872)
    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of DOK3 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK3


    Pathways & Interactions
    for DOK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DOK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1B Cell Receptor Signaling Pathway
    		B Cell Receptor Signaling Pathway


    1 BioSystems Pathway for DOK3
        B Cell Receptor Signaling Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DOK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/16 Interacting proteins for DOK3 (Q7L5912, 3 ENSP000003497274) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INPP5DQ928352, 3, ENSP000003525754MINT-4329711 I2D: score=2 STRING: ENSP00000352575
    GRB2P629932, 3, ENSP000003390074MINT-8034859 MINT-8035813 MINT-8287491 I2D: score=1 STRING: ENSP00000339007
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    CSKP412403, ENSP000002200034I2D: score=1 STRING: ENSP00000220003
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265Ras protein signal transduction IEA--

    DOK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DOK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOK3

    Search CenterWatch for drugs/clinical trials and news about DOK3

    Transcripts
    for DOK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DOK3 gene (3 alternative transcripts): 
    NM_001144875.1  NM_001144876.1  NM_024872.2  

    Unigene Cluster for DOK3:

    Docking protein 3
    Hs.720849  [show with all ESTs]
    Unigene Representative Sequence: BC004867
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312943(uc003mhi.4 uc003mhj.4) ENST00000500323(uc003mhh.4)
    ENST00000377112 ENST00000357198(uc003mhk.3) ENST00000501403 ENST00000510380
    ENST00000506493 ENST00000502885 ENST00000510898 ENST00000509310 ENST00000502380
    ENST00000512660 ENST00000510389
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DOK3
    SwitchGear 3'UTR luciferase reporter plasmid: DOK3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DOK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOK3
    Clone
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    OriGene ORF clones in mouse, rat for DOK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DOK3 (NM_024872)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK3
    Sirion Biotech Customized lentivirus for stable overexpression of DOK3 
                         Customized lentivirus expression plasmids for stable overexpression of DOK3 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOK3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOK3

    Additional mRNA sequence: 

    AK026223.1 AK097258.1 AK307300.1 AL833678.1 BC004564.2 BC004867.2 

    13 DOTS entries:

    DT.65286148  DT.207179  DT.100816137  DT.86844545  DT.120862448  DT.92426270  DT.101976334  DT.120862388 
    DT.120862369  DT.120862371  DT.120862381  DT.120862416  DT.65287309 

    24/120 AceView cDNA sequences (see all 120):

    CD367823 BG756981 AA765866 BF795410 BQ030365 CR595723 BM479812 AA281131 
    AW406678 BI907755 BC004867 BQ422792 AW505181 BG546489 AA362163 AK097258 
    BM454634 BI521096 BI837113 AK026223 BF477398 BV175653 BG755256 BQ433101 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DOK3 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:        -     -     -     -     -     -     -           -     -     -                                   -     -               
    SP2:        -     -     -     -     -                       -     -     -                                   -     -               
    SP3:                                -                       -     -     -                                                         
    SP4:        -     -     -     -     -                       -     -     -     -     -                       -     -               
    SP5:                                -     -     -           -     -     -                                                         


    ECgene alternative splicing isoforms for DOK3

    Expression
    for DOK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DOK3 Expression
    About this image


    See DOK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOK3

    SOURCE GeneReport for Unigene cluster: Hs.720849

    UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591
    Tissue specificity: Expressed in spleen

        SABiosciences Expression via Pathway-Focused PCR Array including DOK3: 
              Insulin Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK3

    Orthologs
    for DOK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DOK3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dok31 , 5 docking protein 31, 5 79.77(n)1
    78.41(a)1    		   13 (30.06 cM)5
    272611  NM_013739.21  NP_038767.11 
     555232355 
    chicken
    (Gallus gallus)    		 Aves DOK31 docking protein 3 59.51(n)
    47.56(a)    		   429960  NM_001083363.1  NP_001076832.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DOK36
    --
    		 --
    		 38(a)
    24(a)
    		 1 ↔ 1
    possible ortholog
    		 2(145622370-145637992)
    GL343867.1(157196-161799)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003339721 docking protein 3-like 47.74(n)
    38.32(a)    		   100333972  XM_002664489.1  XP_002664535.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dok6
    		 Downstream of kinase
    		 11(a)
    		 1 → many
    		 X(7218251-7222839)


    ENSEMBL Gene Tree for DOK3 (if available)
    TreeFam Gene Tree for DOK3 (if available)

    Paralogs
    for DOK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOK3 gene
    DOK62  DOK12  DOK42  DOK22  DOK52  
    2 SIMAP similar genes for DOK3 using alignment to 8 protein entries:     DOK3_HUMAN (see all proteins):
    FRS2    DOK1

    DOK3 for paralogs           About GeneDecksing



    Genomic Variants
    for DOK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/332 SNPs in DOK3 are shown (see all 332)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1117867241,2
    		C,F--176928454(+) GCCTCT/ATGGCC 2 -- int12Minor allele frequency- A:0.05CSA WA 119
    rs344403081,2
    		C,F--176928514(-) ATTTCG/AGCTCA 2 -- int12Minor allele frequency- A:0.12NA 122
    rs285873021,2
    		C--176928515(+) GAGCCG/AAAATC 2 -- int112Minor allele frequency- A:0.02WA NA CSA EA 374
    rs1806706881,2
    		--176928719(+) ACAGAC/GCTTCG 2 -- int10--------
    rs556431061,2
    		C,F--176928835(+) TGAGCG/ATGGAT 2 -- int12Minor allele frequency- A:0.04WA 120
    rs1851048571,2
    		--176928840(+) GTGGAC/TGCCCA 2 -- int10--------
    rs1891832881,2
    		--176928841(+) TGGATA/GCCCAG 2 -- int10--------
    rs1438287931,2
    		--176928862(+) CCAGAC/TTGATG 2 -- int10--------
    rs284462421,2
    		C,F,H--176929080(+) ATTGTT/CATGAG 2 -- ut315Minor allele frequency- C:0.01EA NS NA 512
    rs14222681,2
    		C,F,O,H--176929130(-) CACTCA/GGCTCT 2 -- ut31 ese317Minor allele frequency- G:0.17MN NS EA NA WA CSA 978

    HapMap Linkage Disequilibrium report for DOK3 (176928905 - 176938275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DOK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6379n71CNV Loss21882294
    nsv883180CNV Loss21882294
    nsv883177CNV Loss21882294
    dgv6383n71CNV Loss21882294
    dgv6381n71CNV Loss21882294
    nsv883164CNV Loss21882294

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    Disorders / Diseases
    for DOK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 611435    OMIM disorders: --

    2 diseases for DOK3:    About MalaCards
    neuronitis    


    DOK3 for disorders           About GeneDecksing


    Export disorders for DOK3 gene to outside databases

    Publications
    for DOK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOK3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with DOK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)1, 2, 3 Favre C....Nunes J.A. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. (PubMed id 10733577)1, 3 Lemay S....Veillette A. (2000)
    5. Proteomic analysis of integrin alphaIIbbeta3 outside- in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PubMed id 19682241)1, 9 Senis Y.A....GarcA-a A. (2009)
    6. The Dok-3/Grb2 protein signal module attenuates Lyn ki nase-dependent activation of Syk kinase in B cell antigen receptor microclusters . (PubMed id 23223229)1 Losing M....Engelke M. (2013)
    7. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    8. DOK3 negatively regulates LPS responses and endotoxin tolerance. (PubMed id 22761938)1 Peng Q....Humphrey M.B. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. The B-cell antigen receptor signals through a preform ed transducer module of SLP65 and CIN85. (PubMed id 21822214)1 Oellerich T....Wienands J. (2011)

    External Searches for DOK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DOK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79930 HGNC: 24583 AceView: DOK3 Ensembl:ENSG00000146094 euGenes: HUgn79930
    ECgene: DOK3 H-InvDB: DOK3

    Other Databases showing DOK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DOK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DOK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DOK3 gene:
    Search GeneIP for patents involving DOK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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