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DOK3 Gene

protein-coding   GIFtS: 50
GCID: GC05M176928

Docking Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Docking Protein 31 2
Downstream Of Tyrosine Kinase 32 3
DOKL2 5
Dok-Like Protein2

External Ids:    HGNC: 245831   Entrez Gene: 799302   Ensembl: ENSG000001460947   OMIM: 6114355   UniProtKB: Q7L5913   

Export aliases for DOK3 gene to outside databases

Previous GC identifers: GC00U916977 GC05M176861 GC05M171849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DOK3 Gene:
DOK3 (docking protein 3) is a protein-coding gene. Diseases associated with DOK3 include inflammatory bowel disease, and neuronitis. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells
through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)

Gene Wiki entry for DOK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DOK3 gene promoter:
         E2F   AP-1   STAT3   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOK3 promoter sequence
   Search Chromatin IP Primers for DOK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35

DOK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176928:  view genomic region     (about GC identifiers)

Start:
176,928,905 bp from pter      End:
176,938,275 bp from pter
Size:
9,371 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591 (See protein sequence)
Recommended Name: Docking protein 3  
Size: 496 amino acids; 53288 Da
Subunit: On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and
Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1
through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity)
Secondary accessions: E9PAT0 H7BXS0 Q8N864 Q9BQB3 Q9H666
Alternative splicing: 4 isoforms:  Q7L591-1   Q7L591-2   Q7L591-3   Q7L591-4   (No experimental confirmation available. Ref.1 (BAC04986) sequence is in conflict in position: 200:R->C)

Explore the universe of human proteins at neXtProt for DOK3: NX_Q7L591

Explore proteomics data for DOK3 at MOPED

Post-translational modifications: 

  • Constitutively tyrosine-phosphorylated (By similarity)1
  • On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be
    phosphorylated by ABL1 kinase (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138347.1  NP_001138348.1  NP_079148.2  

    ENSEMBL proteins: 
     ENSP00000325174   ENSP00000366316   ENSP00000349727   ENSP00000421688   ENSP00000422395  
     ENSP00000423328   ENSP00000423635   ENSP00000424726   ENSP00000424580   ENSP00000426694  

    DOK3 Human Recombinant Protein Products:

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    Novus Biologicals DOK3 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DOK3

    DOK3 Antibody Products:

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    DOK3 Assay Products:

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    Cloud-Clone Corp. ELISAs for DOK3
    Cloud-Clone Corp. CLIAs for DOK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q7L591

    ProtoNet protein and cluster: Q7L591

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591
    Domain: PTB domain mediates receptor interaction (By similarity)
    Similarity: Belongs to the DOK family. Type A subfamily
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    DOK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK3_HUMAN, Q7L591
    Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
    for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells
    through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI17290227
         
    DOK3 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dok3):
     hematopoietic system  immune system  mortality/aging  respiratory system  tumorigenesis 

    DOK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dok3tm1Ppp for DOK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOK3

    miRNA
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    miRTarBase miRNAs that target DOK3:
    hsa-mir-320a (MIRT044507)

    Block miRNA regulation of human, mouse, rat DOK3 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidDOK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DOK3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DOK3

    Clone
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    OriGene ORF clones in mouse, rat for DOK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DOK3 (NM_024872)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DOK3_HUMAN, Q7L591: Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    DOK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOK3 About    
    See pathways by source

    SuperPathContained pathways About
    1B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway


    1 BioSystems Pathway for DOK3
        B Cell Receptor Signaling Pathway


        Pathway & Disease-focused RT2 Profiler PCR Array including DOK3: 
              Insulin Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DOK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for DOK3 (Q7L5911, 2, 3 ENSP000003497274) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INPP5DQ928352, 3, ENSP000003525754MINT-4329711 I2D: score=2 STRING: ENSP00000352575
    GRB2P629932, 3, ENSP000003390074MINT-8034859 MINT-8035813 MINT-8287491 I2D: score=1 STRING: ENSP00000339007
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    CSKP412403, ENSP000002200034I2D: score=1 STRING: ENSP00000220003
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265Ras protein signal transduction IEA--

    DOK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOK3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DOK3 gene (3 alternative transcripts): 
    NM_001144875.1  NM_001144876.1  NM_024872.2  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312943(uc003mhi.4 uc003mhj.4) ENST00000500323(uc003mhh.4)
    ENST00000377112 ENST00000357198(uc003mhk.3) ENST00000501403 ENST00000510380
    ENST00000506493 ENST00000502885 ENST00000510898 ENST00000509310 ENST00000502380
    ENST00000512660 ENST00000510389
    miRNA
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    Block miRNA regulation of human, mouse, rat DOK3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DOK3
    SwitchGear 3'UTR luciferase reporter plasmidDOK3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DOK3
    Predesigned siRNA for gene silencing in human, mouse, rat DOK3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DOK3 (NM_024872)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DOK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOK3
      QuantiTect SYBR Green Assays in human, mouse, rat DOK3
      QuantiFast Probe-based Assays in human, mouse, rat DOK3

    Selected AceView cDNA sequences (see all 120):

    BF795410 BM479812 CD367823 CR595723 AA765866 BG756981 BQ030365 BG754710 
    AK097258 BF477398 BV175653 AL583057 BQ061745 BQ422792 BG755871 BU158395 
    BQ436982 BX364341 BX337814 BM457606 BQ061336 BI489608 BG546489 BI518837 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DOK3 (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:        -     -     -     -     -     -     -           -     -     -                                   -     -               
    SP2:        -     -     -     -     -                       -     -     -                                   -     -               
    SP3:                                -                       -     -     -                                                         
    SP4:        -     -     -     -     -                       -     -     -     -     -                       -     -               
    SP5:                                -     -     -           -     -     -                                                         


    ECgene alternative splicing isoforms for DOK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DOK3 Expression
    About this image

    DOK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOK3 Protein Expression

    UniProtKB/Swiss-Prot: DOK3_HUMAN, Q7L591
    Tissue specificity: Expressed in spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including DOK3: 
              Insulin Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DOK3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dok31 , 5 docking protein 31, 5 79.77(n)1
    78.41(a)1
      13 (30.06 cM)5
    272611  NM_013739.21  NP_038767.11 
     555232355 
    chicken
    (Gallus gallus)
    Aves DOK31 docking protein 3 60.02(n)
    48.13(a)
      429960  NM_001083363.1  NP_001076832.1 
    lizard
    (Anolis carolinensis)
    Reptilia DOK36
    docking protein 3
    40(a)
    1 ↔ 1
    2(145622370-145637992)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01072950.16
    Uncharacterized protein
    42(a)
    1 ↔ 1
    14(51981054-51997702) ENSDARG00000086910
    fruit fly
    (Drosophila melanogaster)
    Insecta Dok6
    Downstream of kinase
    13(a)
    1 → many
    X(7218251-7222839)


    ENSEMBL Gene Tree for DOK3 (if available)
    TreeFam Gene Tree for DOK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOK3 gene
    DOK62  DOK12  DOK42  DOK22  DOK52  
    2 SIMAP similar genes for DOK3 using alignment to 8 protein entries:     DOK3_HUMAN (see all proteins):
    FRS2    DOK1

    DOK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOK3 (see all 332)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117867241,2
    C,F--176928454(+) GCCTCT/ATGGCC 2 -- int12Minor allele frequency- A:0.05CSA WA 119
    rs344403081,2
    C,F--176928514(-) ATTTCG/AGCTCA 2 -- int12Minor allele frequency- A:0.12NA 122
    rs285873021,2
    C--176928515(+) GAGCCG/AAAATC 2 -- int112Minor allele frequency- A:0.02WA NA CSA EA 374
    rs1806706881,2
    --176928719(+) ACAGAC/GCTTCG 2 -- int10--------
    rs556431061,2
    C,F--176928835(+) TGAGCG/ATGGAT 2 -- int12Minor allele frequency- A:0.04WA 120
    rs1851048571,2
    --176928840(+) GTGGAC/TGCCCA 2 -- int10--------
    rs1891832881,2
    --176928841(+) TGGATA/GCCCAG 2 -- int10--------
    rs1438287931,2
    --176928862(+) CCAGAC/TTGATG 2 -- int10--------
    rs284462421,2
    C,F,H--176929080(+) ATTGTT/CATGAG 2 -- ut315Minor allele frequency- C:0.01EA NS NA 512
    rs14222681,2
    C,F,O,H--176929130(-) CACTCA/GGCTCT 2 -- ut31 ese317Minor allele frequency- G:0.17MN NS EA NA WA CSA 978

    HapMap Linkage Disequilibrium report for DOK3 (176928905 - 176938275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DOK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6379n71CNV Loss21882294
    nsv883180CNV Loss21882294
    nsv883177CNV Loss21882294
    dgv6383n71CNV Loss21882294
    dgv6381n71CNV Loss21882294
    nsv883164CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DOK3
    DNA2.0 Custom Variant and Variant Library Synthesis for DOK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611435    OMIM disorders: --

    2 diseases for DOK3:    
    About MalaCards
    inflammatory bowel disease    neuronitis


    DOK3 for disorders           About GeneDecksing


    Export disorders for DOK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOK3 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with DOK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)1, 2, 3 Favre C.... Nunes J.A. (Genes Immun. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. (PubMed id 10733577)1, 3 Lemay S....Veillette A. (Mol. Cell. Biol. 2000)
    5. Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PubMed id 19682241)1, 9 Senis Y.A....GarcA-a A. (J. Thromb. Haemost. 2009)
    6. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters. (PubMed id 23223229)1 LAPsing M....Engelke M. (J. Biol. Chem. 2013)
    7. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    8. DOK3 negatively regulates LPS responses and endotoxin tolerance. (PubMed id 22761938)1 Peng Q....Humphrey M.B. (PLoS ONE 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. (PubMed id 21822214)1 Oellerich T....Wienands J. (EMBO J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79930 HGNC: 24583 AceView: DOK3 Ensembl:ENSG00000146094 euGenes: HUgn79930
    ECgene: DOK3 H-InvDB: DOK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOK3 gene:
    Search GeneIP for patents involving DOK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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