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Aliases for DOK2 Gene

Aliases for DOK2 Gene

  • Docking Protein 2, 56kDa 2 3
  • Downstream Of Tyrosine Kinase 2 3 4
  • Docking Protein 2, 56kD 2 3
  • P56(Dok-2) 3 4
  • P56DOK 3 6
  • Docking Protein 2 3
  • P56dok-2 3

External Ids for DOK2 Gene

Summaries for DOK2 Gene

Entrez Gene Summary for DOK2 Gene

  • The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DOK2 Gene

DOK2 (Docking Protein 2, 56kDa) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Hemostasis. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK2 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

Gene Wiki entry for DOK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK2 Gene

Genomics for DOK2 Gene

Genomic Location for DOK2 Gene

Start:
21,908,873 bp from pter
End:
21,913,860 bp from pter
Size:
4,988 bases
Orientation:
Minus strand

Genomic View for DOK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK2 Gene

Regulatory Elements for DOK2 Gene

Proteins for DOK2 Gene

  • Protein details for DOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60496-DOK2_HUMAN
    Recommended name:
    Docking protein 2
    Protein Accession:
    O60496
    Secondary Accessions:
    • Q8N5A4

    Protein attributes for DOK2 Gene

    Size:
    412 amino acids
    Molecular mass:
    45379 Da
    Quaternary structure:
    • Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).

    Three dimensional structures from OCA and Proteopedia for DOK2 Gene

neXtProt entry for DOK2 Gene

Proteomics data for DOK2 Gene at MOPED

Post-translational modifications for DOK2 Gene

  • On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys7

Other Protein References for DOK2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DOK2 Gene

Domains for DOK2 Gene

Protein Domains for DOK2 Gene

UniProtKB/Swiss-Prot:

DOK2_HUMAN
Domain:
  • PTB domain mediates receptor interaction:
    • O60496
  • Contains 1 IRS-type PTB domain.:
    • O60496
  • Contains 1 PH domain.:
    • O60496
Family:
  • Belongs to the DOK family. Type A subfamily.:
    • O60496
genes like me logo Genes that share domains with DOK2: view

No data available for Gene Families for DOK2 Gene

Function for DOK2 Gene

Molecular function for DOK2 Gene

UniProtKB/Swiss-Prot Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

Gene Ontology (GO) - Molecular Function for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IEA --
GO:0005158 insulin receptor binding IEA --
genes like me logo Genes that share ontologies with DOK2: view
genes like me logo Genes that share phenotypes with DOK2: view

Animal Models for DOK2 Gene

MGI Knock Outs for DOK2:

miRNA for DOK2 Gene

miRTarBase miRNAs that target DOK2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DOK2 Gene

Localization for DOK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOK2 Gene COMPARTMENTS Subcellular localization image for DOK2 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOK2: view

Pathways for DOK2 Gene

genes like me logo Genes that share pathways with DOK2: view

Gene Ontology (GO) - Biological Process for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10799545
GO:0007166 cell surface receptor signaling pathway TAS 10799545
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007265 Ras protein signal transduction IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with DOK2: view

Compounds for DOK2 Gene

(2) Novoseek inferred chemical compound relationships for DOK2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 55.7 14
phosphotyrosine 44.5 1
genes like me logo Genes that share compounds with DOK2: view

Transcripts for DOK2 Gene

Unigene Clusters for DOK2 Gene

Docking protein 2, 56kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOK2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for DOK2 Gene

GeneLoc Exon Structure for
DOK2
ECgene alternative splicing isoforms for
DOK2

Expression for DOK2 Gene

mRNA expression in normal human tissues for DOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK2 Gene

This gene is overexpressed in Whole Blood (24.8) and Spleen (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOK2 Gene

SOURCE GeneReport for Unigene cluster for DOK2 Gene Hs.71215

mRNA Expression by UniProt/SwissProt for DOK2 Gene

O60496-DOK2_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
genes like me logo Genes that share expressions with DOK2: view

Orthologs for DOK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK2 36
  • 99.11 (n)
  • 99.27 (a)
DOK2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DOK2 36
  • 82.77 (n)
  • 83.98 (a)
DOK2 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOK2 36
  • 85.28 (n)
  • 85.44 (a)
DOK2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dok2 36
  • 77.86 (n)
  • 76.05 (a)
Dok2 16
Dok2 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOK2 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOK2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dok2 36
  • 77.78 (n)
  • 77.29 (a)
chicken
(Gallus gallus)
Aves DOK2 36
  • 58.68 (n)
  • 51.83 (a)
DOK2 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dok2 36
  • 53.09 (n)
  • 47.52 (a)
zebrafish
(Danio rerio)
Actinopterygii dok2 36
  • 53.96 (n)
  • 48.09 (a)
dok2 37
  • 32 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dok 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 37
  • 24 (a)
OneToMany
Species with no ortholog for DOK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK2 Gene

ENSEMBL:
Gene Tree for DOK2 (if available)
TreeFam:
Gene Tree for DOK2 (if available)

Paralogs for DOK2 Gene

Paralogs for DOK2 Gene

Selected SIMAP similar genes for DOK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DOK2: view

Variants for DOK2 Gene

Sequence variations from dbSNP and Humsavar for DOK2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs899428 -- 21,913,252(-) GCTCT(A/G)TGTTG intron-variant
rs1140295 - 21,910,837(-) AATTT(C/G)CTGTG missense, reference, utr-variant-5-prime
rs2086234 -- 21,909,759(-) GTCGC(G/T)GCCCC missense, reference
rs2242240 -- 21,909,764(-) CCCGC(A/C/G)TCGCT synonymous-codon, reference
rs2242241 - 21,909,370(-) CTGCT(G/T)CTGGC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for DOK2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850

Relevant External Links for DOK2 Gene

HapMap Linkage Disequilibrium report
DOK2

Disorders for DOK2 Gene

Relevant External Links for DOK2

Genetic Association Database (GAD)
DOK2
Human Genome Epidemiology (HuGE) Navigator
DOK2
genes like me logo Genes that share disorders with DOK2: view

No data available for UniProtKB/Swiss-Prot for DOK2 Gene

Publications for DOK2 Gene

  1. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. (PMID: 9478921) Di Cristofano A. … Resh M.D. (J. Biol. Chem. 1998) 2 3 4 23
  2. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. (PMID: 14645010) Garcia A. … Zitzmann N. (Blood 2004) 2 3 23
  3. Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. (PMID: 14647425) GAcrard A. … NunA"s J.A. (Oncogene 2004) 3 23
  4. Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. (PMID: 19786546) Mihrshahi R. … Brown M.H. (J. Immunol. 2009) 3 23
  5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4

Products for DOK2 Gene

Sources for DOK2 Gene

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