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DOK2 Gene

protein-coding   GIFtS: 63
GCID: GC08M021766

Docking Protein 2, 56kDa

(Previous names: docking protein 2, 56kD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Docking Protein 2, 56kDa1 2     Docking Protein 22
Downstream Of Tyrosine Kinase 22 3     p56DOK2
p56(dok-2)2 3     p56dok-22
Docking Protein 2, 56kD1     P56DOK5

External Ids:    HGNC: 29911   Entrez Gene: 90462   Ensembl: ENSG000001474437   OMIM: 6049975   UniProtKB: O604963   

Export aliases for DOK2 gene to outside databases

Previous GC identifers: GC08M021526 GC08M022119 GC08M021788 GC08M021822 GC08M020309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOK2 Gene:
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated
from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for
p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP)
from CML cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for DOK2 Gene:
DOK2 (docking protein 2, 56kDa) is a protein-coding gene. Diseases associated with DOK2 include leukemia, and acute leukemia. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK6.

UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by
IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP
kinase activation (By similarity)

Gene Wiki entry for DOK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOK2 gene promoter:
         Elk-1   NRSF form 1   FOXD1   RelA   NRSF form 2   GATA-2   CREB   SRY   deltaCREB   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOK2 promoter sequence
   Search Chromatin IP Primers for DOK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.3

DOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M021766:  view genomic region     (about GC identifiers)

Start:
21,766,384 bp from pter      End:
21,771,371 bp from pter
Size:
4,988 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496 (See protein sequence)
Recommended Name: Docking protein 2  
Size: 412 amino acids; 45379 Da
Subunit: Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with
TEK/TIE2 (tyrosine phosphorylated) (By similarity)
2 PDB 3D structures from and Proteopedia for DOK2:
2D9W (3D)        2DLW (3D)    
Secondary accessions: Q8N5A4

Explore the universe of human proteins at neXtProt for DOK2: NX_O60496

Explore proteomics data for DOK2 at MOPED

Post-translational modifications: 

  • On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is
    required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for
    interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity)1
  • Ubiquitination2 at Lys7
  • Modification sites at PhosphoSitePlus

  • See DOK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003965.2  
    ENSEMBL proteins: 
     ENSP00000276420   ENSP00000429508   ENSP00000430729   ENSP00000429224   ENSP00000443602  
    Reactome Protein details: O60496

    DOK2 Human Recombinant Protein Products:

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    Novus Biologicals DOK2 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DOK2

    DOK2 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DOK2

    DOK2 Assay Products:

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    Cloud-Clone Corp. ELISAs for DOK2
    Cloud-Clone Corp. CLIAs for DOK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O60496

    ProtoNet protein and cluster: O60496

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496
    Domain: PTB domain mediates receptor interaction
    Similarity: Belongs to the DOK family. Type A subfamily
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    DOK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOK2_HUMAN, O60496
    Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform
    for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by
    IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP
    kinase activation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005068transmembrane receptor protein tyrosine kinase adaptor activity IEA--
    GO:0005158insulin receptor binding IEA--
         
    DOK2 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dok2):
     hematopoietic system  immune system  mortality/aging  respiratory system  tumorigenesis 

    DOK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dok2tm1Yyam for DOK2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOK2

    miRNA
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    miRTarBase miRNAs that target DOK2:
    hsa-mir-193b-3p (MIRT041270)

    Block miRNA regulation of human, mouse, rat DOK2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DOK2:
    hsa-miR-765 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidDOK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DOK2
    Predesigned siRNA for gene silencing in human, mouse, rat DOK2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DOK2 (see all 6)
    OriGene ORF clones in mouse, rat for DOK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOK2 (NM_003974)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    DOK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOK2 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IL 23 signaling pathway
    Development Angiopoietin Tie2 signaling0.38
    Angiopoietin receptor Tie2-mediated signaling0.32
    Angiopoietin-TIE2 Signaling0.36
    2Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39
    GDNF-Family Ligands and Receptor Interactions0.41
    3G protein signaling TC21 regulation pathway
    G protein signaling TC21 regulation pathway0.71
    G protein signaling M RAS regulation pathway0.71
    4Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    Tie2 Signaling0.00
    5IL2-mediated signaling events
    IL2-mediated signaling events0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DOK2
        EGF Pathway
    GDNF-Family Ligands and Receptor Interactions
    Angiopoietin-TIE2 Signaling

    1 Cell Signaling Technology (CST) Pathway for DOK2
        Tyrosine Kinases / Adaptors

    Selected GeneGo (Thomson Reuters) Pathways for DOK2 (see all 6)
        G-protein signaling H-RAS regulation pathway
    G-protein signaling TC21 regulation pathway
    G-protein signaling M-RAS regulation pathway
    Development EGFR signaling pathway
    Development EGFR signaling via small GTPases

    5 BioSystems Pathways for DOK2
        EGFR1 Signaling Pathway
    IL-4 signaling Pathway
    IL4-mediated signaling events
    IL2-mediated signaling events
    Angiopoietin receptor Tie2-mediated signaling

    1 Reactome Pathway for DOK2
        Tie2 Signaling



    DOK2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DOK2: 
              Insulin Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DOK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DOK2 (O604962, 3 ENSP000002764204) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163332, 3, ENSP000002889864MINT-8035617 I2D: score=6 STRING: ENSP00000288986
    KIAA1279Q96EK52, 3, ENSP000003548484MINT-66467 I2D: score=5 STRING: ENSP00000354848
    TEKQ027633, ENSP000003839774I2D: score=5 STRING: ENSP00000383977
    RASA1P209363, ENSP000002743764I2D: score=4 STRING: ENSP00000274376
    ABL1P005193, ENSP000003614234I2D: score=2 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10799545
    GO:0007166cell surface receptor signaling pathway TAS10799545
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway ----
    GO:0007265Ras protein signal transduction IEA--
    GO:0007596blood coagulation TAS--

    DOK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOK2

    2 Novoseek inferred chemical compound relationships for DOK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 55.7 17 14647425 (4), 14645010 (2), 16177091 (2), 8985154 (1) (see all 9)
    phosphotyrosine 44.5 1 16177091 (1)



    DOK2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DOK2 gene (2 alternative transcripts): 
    NM_003974.2  NM_201349.1  

    Unigene Cluster for DOK2:

    Docking protein 2, 56kDa
    Hs.71215  [show with all ESTs]
    Unigene Representative Sequence: NM_003974
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276420(uc003wzx.1 uc003wzy.1 uc003wzz.1 uc010lth.1)
    ENST00000524001 ENST00000517422 ENST00000518197 ENST00000523932 ENST00000522011
    ENST00000544659

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate DOK2:
    hsa-miR-765 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidDOK2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DOK2 (NM_003974)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK2
    Primer
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    OriGene qPCR primer pairs and template standards for DOK2
    OriGene qSTAR qPCR primer pairs in human, mouse for DOK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOK2
      QuantiTect SYBR Green Assays in human, mouse, rat DOK2
      QuantiFast Probe-based Assays in human, mouse, rat DOK2

    Additional mRNA sequence: 

    AF034970.1 AK226110.1 AK292126.1 AK296671.1 BC032623.1 

    6 DOTS entries:

    DT.409458  DT.100777519  DT.100776025  DT.95302807  DT.409459  DT.92416977 

    Selected AceView cDNA sequences (see all 78):

    CA306148 CR602622 NM_201349 CR611181 CR626090 CD369937 NM_003974 AA936619 
    AA380752 BQ073121 CR597117 AI826859 BM922310 CB529846 BI821037 BM996521 
    BM918675 BX414717 BI836532 CD743150 AL545512 BI916932 CD368678 CA430343 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DOK2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
    SP1:              -     -                       -                                             
    SP2:              -     -                       -           -                                 
    SP3:              -     -                 -     -                                             
    SP4:              -     -     -     -     -     -                                             
    SP5:                                      -     -                                             


    ECgene alternative splicing isoforms for DOK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAGCCAGC
    DOK2 Expression
    About this image


    DOK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Cells Epiblast
    DOK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.71215

    UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496
    Tissue specificity: Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in
    thymus, bone marrow and fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Array including DOK2: 
              Insulin Signaling Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DOK2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOK2
    QuantiTect SYBR Green Assays in human, mouse, rat DOK2
    QuantiFast Probe-based Assays in human, mouse, rat DOK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DOK2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dok21 , 5 docking protein 21, 5 77.86(n)1
    76.05(a)1
      14 (36.71 cM)5
    134491  NM_010071.21  NP_034201.11 
     707660365 
    chicken
    (Gallus gallus)
    Aves DOK21 docking protein 2, 56kDa 58.68(n)
    51.83(a)
      100857332  XM_003642549.2  XP_003642597.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dok21 docking protein 2, 56kDa 53.09(n)
    47.52(a)
      100487659  XM_002932696.2  XP_002932742.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dok21 docking protein 2 53.96(n)
    48.09(a)
      100001537  XM_001341478.5  XP_001341514.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dok6
    Downstream of kinase
    16(a)
    1 → many
    X(7218251-7222839)


    ENSEMBL Gene Tree for DOK2 (if available)
    TreeFam Gene Tree for DOK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOK2 gene
    DOK62  DOK12  DOK42  DOK32  DOK52  
    2 SIMAP similar genes for DOK2 using alignment to 5 protein entries:     DOK2_HUMAN (see all proteins):
    FRS2    DOK1

    DOK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOK2 (see all 245)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1181124131,2
    F--21765905(+) AGCAAG/CCACAA 1 -- ds50011Minor allele frequency- C:0.01EA 120
    rs1470246041,2
    --21765906(+) GCAAGC/TACAAG 1 -- ds50010--------
    rs1383182511,2
    --21765911(+) CACAAA/GGACAC 1 -- ds50010--------
    rs1908318241,2
    C--21766018(+) ACCCCC/GTCATT 1 -- ds50010--------
    rs1810008681,2
    C--21766094(+) ACTCCG/TGGTGT 1 -- ds50010--------
    rs175817641,2
    C,F,H--21766101(+) GTGTAC/TAAGAG 1 -- ds500199Minor allele frequency- T:0.26NA NS EA PA EU CA WA 6682
    rs1413146591,2
    --21766123(+) CCAATG/TATTTC 1 -- ds50010--------
    rs1508074961,2
    --21766271(+) GTGAGA/CAGATG 1 -- ds50010--------
    rs1391362731,2
    C--21766401(+) GCTTTA/CATGCC 1 -- ut310--------
    rs1495227221,2
    --21766733(+) CCAGAA/TGGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DOK2 (21766384 - 21771371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DOK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    essv21913CNV CNV17122850
    essv19243CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOK2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604997    OMIM disorders: --

    8 diseases for DOK2:    
    About MalaCards
    leukemia    acute leukemia    gastric adenocarcinoma    tonsillitis
    alzheimer's disease    colorectal cancer    adenocarcinoma    neuronitis


    DOK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): DOK2
    Human Genome Epidemiology (HuGE) Navigator: DOK2 (4 documents)

    Export disorders for DOK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOK2 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with DOK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. (PubMed id 9478921)1, 2, 3, 9 Di Cristofano A.... Resh M.D. (J. Biol. Chem. 1998)
    2. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. (PubMed id 14645010)1, 3, 9 Garcia A.... Zitzmann N. (Blood 2004)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation. (PubMed id 16177091)1, 9 Boulay I....Duplay P. (J. Immunol. 2005)
    8. Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. (PubMed id 14647425)1, 9 GAcrard A....NunA"s J.A. (Oncogene 2004)
    9. Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. (PubMed id 19786546)1, 9 Mihrshahi R....Brown M.H. (J. Immunol. 2009)
    10. All-trans retinoic acid induces p62DOK1 and p56DOK2 expression which enhances induced differentiation and G0 arrest of HL-60 leukemia cells. (PubMed id 16823827)1, 9 Lamkin T.J....Yen A. (Am. J. Hematol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9046 HGNC: 2991 AceView: DOK2 Ensembl:ENSG00000147443 euGenes: HUgn9046
    ECgene: DOK2 H-InvDB: DOK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DOK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DOK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DOK2 gene:
    Search GeneIP for patents involving DOK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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