Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DOK2 Gene

Aliases for DOK2 Gene

  • Docking Protein 2 2 3 5
  • Downstream Of Tyrosine Kinase 2 2 3 4
  • Docking Protein 2, 56kDa 2 3
  • Docking Protein 2, 56kD 2 3
  • P56(Dok-2) 3 4
  • P56dok-2 3
  • P56DOK 3

External Ids for DOK2 Gene

Previous GeneCards Identifiers for DOK2 Gene

  • GC08M021526
  • GC08M022119
  • GC08M021788
  • GC08M021822
  • GC08M020309
  • GC08M021766

Summaries for DOK2 Gene

Entrez Gene Summary for DOK2 Gene

  • The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DOK2 Gene

DOK2 (Docking Protein 2) is a Protein Coding gene. Among its related pathways are RET signaling and G-protein signaling_H-RAS regulation pathway. GO annotations related to this gene include signal transducer activity, downstream of receptor and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK2 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

Gene Wiki entry for DOK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK2 Gene

Genomics for DOK2 Gene

Regulatory Elements for DOK2 Gene

Enhancers for DOK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F021917 1.2 FANTOM5 ENCODE 1.5 -6.3 -6255 4.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YY1 ZNF207 POLR3D ENSG00000253200 BIN3 SORBS3 C8orf58 FGF17 NPM2 GFRA2 DMTN DOK2
GH08F022190 1.2 FANTOM5 Ensembl ENCODE 1.5 -279.0 -278959 4.6 MLX ZNF133 ARID4B ZNF335 GLIS2 FOS EGR2 SMARCA5 ZNF202 TGIF2 ENSG00000253200 BMP1 POLR3D C8orf58 SORBS3 ENSG00000251034 PPP3CC XPO7 DOK2 LOC105379319
GH08F021683 1 FANTOM5 Ensembl ENCODE 1.3 +229.6 229560 2.2 ESRRA JUN ZBTB40 ZIC2 ZFHX2 GATA3 CTBP1 GLIS2 SCRT2 FOS DOK2 GC08P021598 PIR47014
GH08F021915 0.2 ENCODE 0.8 -1.5 -1536 0.0 CTCF ESRRA TBL1XR1 WRNIP1 ARID4B RAD21 TEAD3 SMC3 THAP11 ZNF654 NPM2 FGF17 DOK2 XPO7
GH08F021916 0.6 ENCODE 0.8 -1.6 -1635 0.2 CTCF ESRRA TBL1XR1 WRNIP1 ARID4B RAD21 TEAD3 ZBTB48 SMC3 THAP11 NPM2 FGF17 DOK2 XPO7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DOK2 on UCSC Golden Path with GeneCards custom track

Promoters for DOK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001387381 1060 2001 CTCF MXI1 EBF1 ZBTB40 ZFHX2 POLR2A EGR1 CREM MAZ CBFB

Genomic Location for DOK2 Gene

Chromosome:
8
Start:
21,908,873 bp from pter
End:
21,913,860 bp from pter
Size:
4,988 bases
Orientation:
Minus strand

Genomic View for DOK2 Gene

Genes around DOK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK2 Gene

Proteins for DOK2 Gene

  • Protein details for DOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60496-DOK2_HUMAN
    Recommended name:
    Docking protein 2
    Protein Accession:
    O60496
    Secondary Accessions:
    • Q8N5A4

    Protein attributes for DOK2 Gene

    Size:
    412 amino acids
    Molecular mass:
    45379 Da
    Quaternary structure:
    • Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).

    Three dimensional structures from OCA and Proteopedia for DOK2 Gene

neXtProt entry for DOK2 Gene

Post-translational modifications for DOK2 Gene

  • On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).
  • Ubiquitination at Lys 7
  • Modification sites at PhosphoSitePlus

Other Protein References for DOK2 Gene

No data available for DME Specific Peptides for DOK2 Gene

Domains & Families for DOK2 Gene

Protein Domains for DOK2 Gene

Suggested Antigen Peptide Sequences for DOK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60496

UniProtKB/Swiss-Prot:

DOK2_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type A subfamily.
Domain:
  • PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK2: view

No data available for Gene Families for DOK2 Gene

Function for DOK2 Gene

Molecular function for DOK2 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

Gene Ontology (GO) - Molecular Function for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor IEA --
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IEA --
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with DOK2: view
genes like me logo Genes that share phenotypes with DOK2: view

Animal Models for DOK2 Gene

MGI Knock Outs for DOK2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK2 Gene

Localization for DOK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOK2 Gene COMPARTMENTS Subcellular localization image for DOK2 gene
Compartment Confidence
cytosol 5
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOK2 Gene

Pathways & Interactions for DOK2 Gene

genes like me logo Genes that share pathways with DOK2: view

Gene Ontology (GO) - Biological Process for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9478921
GO:0007166 cell surface receptor signaling pathway TAS 10799545
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007265 Ras protein signal transduction IEA --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with DOK2: view

No data available for SIGNOR curated interactions for DOK2 Gene

Drugs & Compounds for DOK2 Gene

(1) Drugs for DOK2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for DOK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DOK2: view

Transcripts for DOK2 Gene

Unigene Clusters for DOK2 Gene

Docking protein 2, 56kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOK2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for DOK2 Gene

GeneLoc Exon Structure for
DOK2
ECgene alternative splicing isoforms for
DOK2

Expression for DOK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK2 Gene

This gene is overexpressed in Whole Blood (x24.8) and Spleen (x6.1).

Protein differential expression in normal tissues from HIPED for DOK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.1), Nasal epithelium (9.1), and NK cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOK2 Gene



Protein tissue co-expression partners for DOK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DOK2 Gene:

DOK2

SOURCE GeneReport for Unigene cluster for DOK2 Gene:

Hs.71215

mRNA Expression by UniProt/SwissProt for DOK2 Gene:

O60496-DOK2_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
genes like me logo Genes that share expression patterns with DOK2: view

Primer Products

Orthologs for DOK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK2 34 35
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia DOK2 34 35
  • 85.28 (n)
cow
(Bos Taurus)
Mammalia DOK2 34 35
  • 82.77 (n)
mouse
(Mus musculus)
Mammalia Dok2 34 16 35
  • 77.86 (n)
rat
(Rattus norvegicus)
Mammalia Dok2 34
  • 77.78 (n)
oppossum
(Monodelphis domestica)
Mammalia DOK2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOK2 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK2 34 35
  • 58.68 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia dok2 34
  • 53.09 (n)
zebrafish
(Danio rerio)
Actinopterygii dok2 34 35
  • 53.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dok 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 35
  • 24 (a)
OneToMany
Species where no ortholog for DOK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK2 Gene

ENSEMBL:
Gene Tree for DOK2 (if available)
TreeFam:
Gene Tree for DOK2 (if available)

Paralogs for DOK2 Gene

Paralogs for DOK2 Gene

(2) SIMAP similar genes for DOK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DOK2: view

Variants for DOK2 Gene

Sequence variations from dbSNP and Humsavar for DOK2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs111470868 -- 21,912,097(+) ACTGG(A/G)TTCGG intron-variant
rs111543087 -- 21,909,728(+) TCATG(C/T)GGCCG reference, synonymous-codon
rs111623053 -- 21,911,900(+) CCTCA(A/C/G)CTGTG intron-variant, splice-donor-variant
rs112710387 -- 21,911,749(+) AAGCG(A/G)GAAGG intron-variant
rs11313762 -- 21,912,209(+) CCTTT(-/C)CGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOK2 Gene

Variant ID Type Subtype PubMed ID
dgv7131n100 CNV gain 25217958
dgv7132n100 CNV gain 25217958
esv2759604 CNV loss 17122850
nsv1023009 CNV gain 25217958

Variation tolerance for DOK2 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK2 Gene

Disorders for DOK2 Gene

Relevant External Links for DOK2

Genetic Association Database (GAD)
DOK2
Human Genome Epidemiology (HuGE) Navigator
DOK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK2

No disorders were found for DOK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK2 Gene

Publications for DOK2 Gene

  1. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. (PMID: 9478921) Di Cristofano A. … Resh M.D. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. (PMID: 14645010) Garcia A. … Zitzmann N. (Blood 2004) 2 3 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. (PMID: 19299694) Guittard G. … NunA"s J.A. (J. Immunol. 2009) 3 22 64
  5. Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. (PMID: 19786546) Mihrshahi R. … Brown M.H. (J. Immunol. 2009) 3 22 64

Products for DOK2 Gene

Sources for DOK2 Gene

Content
Loading form....