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Aliases for DOK2 Gene

Aliases for DOK2 Gene

  • Docking Protein 2 2 3 5
  • Downstream Of Tyrosine Kinase 2 2 3 4
  • Docking Protein 2, 56kDa 2 3
  • Docking Protein 2, 56kD 2 3
  • P56(Dok-2) 3 4
  • P56dok-2 3
  • P56DOK 3

External Ids for DOK2 Gene

Previous GeneCards Identifiers for DOK2 Gene

  • GC08M021526
  • GC08M022119
  • GC08M021788
  • GC08M021822
  • GC08M020309
  • GC08M021766

Summaries for DOK2 Gene

Entrez Gene Summary for DOK2 Gene

  • The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DOK2 Gene

DOK2 (Docking Protein 2) is a Protein Coding gene. Among its related pathways are RET signaling and G-protein signaling TC21 regulation pathway. GO annotations related to this gene include signal transducer activity, downstream of receptor and transmembrane receptor protein tyrosine kinase adaptor activity. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK2 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

Gene Wiki entry for DOK2 Gene

Additional gene information for DOK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK2 Gene

Genomics for DOK2 Gene

Regulatory Elements for DOK2 Gene

Enhancers for DOK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H022190 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.5 -279.0 -278959 4 BCOR TFAP4 MXI1 SAP130 MLX ZNF133 ARID4B ZMYM3 BATF TEAD3 BMP1 PPP3CC XPO7 DOK2 LOC105379319 PHYHIP
GH08H021917 1.5 FANTOM5 ENCODE 1.5 -6.3 -6255 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YY1 ZNF766 ZNF207 ENSG00000253200 BIN3 C8orf58 XPO7 FGF17 CCAR2 FAM160B2 NPM2 ENSG00000251034 POLR3D
GH08H021683 1.4 FANTOM5 Ensembl ENCODE 1.3 +229.5 229504 1 FOXA2 ESRRA JUN SIN3A ZIC2 ZBTB40 FOSL1 ZFHX2 CTBP1 GLIS2 DOK2 GC08P021598 PIR47014
GH08H021907 1.2 ENCODE dbSUPER 0.7 +2.4 2408 7 PKNOX1 ARID4B TCF12 ZNF766 GLIS2 ZNF143 FOS ATF7 RUNX3 MXD4 FGF17 NPM2 HR GFRA2 DOK2 GC08M021903
GH08H021915 1 ENCODE dbSUPER 0.7 -1.5 -1536 0 HDAC1 CTCF TBL1XR1 ARID4B RAD21 TEAD3 FOSL1 CC2D1A SMC3 ZNF143 NPM2 FGF17 XPO7 DOK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOK2 on UCSC Golden Path with GeneCards custom track

Promoters for DOK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000221973 860 1201 ZNF687 CBFB ZBED1 ELF1 ZBTB40 ZFHX2 ZNF766 POLR2A EGR1 MLLT1

Genomic Location for DOK2 Gene

Chromosome:
8
Start:
21,908,873 bp from pter
End:
21,913,860 bp from pter
Size:
4,988 bases
Orientation:
Minus strand

Genomic View for DOK2 Gene

Genes around DOK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK2 Gene

Proteins for DOK2 Gene

  • Protein details for DOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60496-DOK2_HUMAN
    Recommended name:
    Docking protein 2
    Protein Accession:
    O60496
    Secondary Accessions:
    • Q8N5A4

    Protein attributes for DOK2 Gene

    Size:
    412 amino acids
    Molecular mass:
    45379 Da
    Quaternary structure:
    • Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).

    Three dimensional structures from OCA and Proteopedia for DOK2 Gene

neXtProt entry for DOK2 Gene

Post-translational modifications for DOK2 Gene

  • On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).
  • Ubiquitination at isoforms=7
  • Modification sites at PhosphoSitePlus

Other Protein References for DOK2 Gene

No data available for DME Specific Peptides for DOK2 Gene

Domains & Families for DOK2 Gene

Gene Families for DOK2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DOK2 Gene

Suggested Antigen Peptide Sequences for DOK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60496

UniProtKB/Swiss-Prot:

DOK2_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type A subfamily.
Domain:
  • PTB domain mediates receptor interaction.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK2: view

Function for DOK2 Gene

Molecular function for DOK2 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).

Phenotypes From GWAS Catalog for DOK2 Gene

Gene Ontology (GO) - Molecular Function for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor IEA --
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IEA --
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with DOK2: view
genes like me logo Genes that share phenotypes with DOK2: view

Animal Models for DOK2 Gene

MGI Knock Outs for DOK2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK2 Gene

Localization for DOK2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOK2 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DOK2 Gene

Pathways & Interactions for DOK2 Gene

genes like me logo Genes that share pathways with DOK2: view

Gene Ontology (GO) - Biological Process for DOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9478921
GO:0007166 cell surface receptor signaling pathway TAS 10799545
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007265 Ras protein signal transduction IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with DOK2: view

No data available for SIGNOR curated interactions for DOK2 Gene

Drugs & Compounds for DOK2 Gene

(1) Drugs for DOK2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for DOK2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DOK2: view

Transcripts for DOK2 Gene

Unigene Clusters for DOK2 Gene

Docking protein 2, 56kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DOK2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e · 5f
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - -
SP6:
SP7:

Relevant External Links for DOK2 Gene

GeneLoc Exon Structure for
DOK2
ECgene alternative splicing isoforms for
DOK2

Expression for DOK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK2 Gene

This gene is overexpressed in Whole Blood (x24.8) and Spleen (x6.1).

Protein differential expression in normal tissues from HIPED for DOK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.1), Nasal epithelium (9.1), and NK cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOK2 Gene



Protein tissue co-expression partners for DOK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DOK2 Gene:

DOK2

SOURCE GeneReport for Unigene cluster for DOK2 Gene:

Hs.71215

mRNA Expression by UniProt/SwissProt for DOK2 Gene:

O60496-DOK2_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.

Evidence on tissue expression from TISSUES for DOK2 Gene

  • Nervous system(4)
  • Blood(2)
genes like me logo Genes that share expression patterns with DOK2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DOK2 Gene

Orthologs for DOK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK2 33 34
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia DOK2 33 34
  • 85.28 (n)
cow
(Bos Taurus)
Mammalia DOK2 33 34
  • 82.77 (n)
mouse
(Mus musculus)
Mammalia Dok2 33 16 34
  • 77.86 (n)
rat
(Rattus norvegicus)
Mammalia Dok2 33
  • 77.78 (n)
oppossum
(Monodelphis domestica)
Mammalia DOK2 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOK2 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK2 33 34
  • 58.68 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia dok2 33
  • 53.09 (n)
zebrafish
(Danio rerio)
Actinopterygii dok2 33 34
  • 53.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dok 34
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 34
  • 24 (a)
OneToMany
Species where no ortholog for DOK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK2 Gene

ENSEMBL:
Gene Tree for DOK2 (if available)
TreeFam:
Gene Tree for DOK2 (if available)

Paralogs for DOK2 Gene

Paralogs for DOK2 Gene

(2) SIMAP similar genes for DOK2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DOK2: view

Variants for DOK2 Gene

Sequence variations from dbSNP and Humsavar for DOK2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000358438 -- 21,910,189(+) GTTGG(C/T)CAGGA intron-variant
rs1000526442 -- 21,913,361(+) GGCCT(C/G)GTTCA intron-variant
rs1000615997 -- 21,911,242(+) CACTG(A/C)CGGGG intron-variant
rs1000730205 -- 21,911,030(+) TCATA(C/G)TCCCC intron-variant
rs1000817263 -- 21,910,085(+) CAAGC(A/G)ATTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOK2 Gene

Variant ID Type Subtype PubMed ID
dgv7131n100 CNV gain 25217958
dgv7132n100 CNV gain 25217958
esv2759604 CNV loss 17122850
nsv1023009 CNV gain 25217958

Variation tolerance for DOK2 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK2 Gene

Disorders for DOK2 Gene

Relevant External Links for DOK2

Genetic Association Database (GAD)
DOK2
Human Genome Epidemiology (HuGE) Navigator
DOK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK2

No disorders were found for DOK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOK2 Gene

Publications for DOK2 Gene

  1. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. (PMID: 9478921) Di Cristofano A … Resh MD (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. (PMID: 14645010) García A … Zitzmann N (Blood 2004) 2 3 22 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. (PMID: 19299694) Guittard G … Nunès JA (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 22 60
  5. Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. (PMID: 19786546) Mihrshahi R … Brown MH (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 22 60

Products for DOK2 Gene

Sources for DOK2 Gene

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