DOK2 Gene
protein-coding GIFtS: 60
GCID: GC08M021822
|
|
docking protein 2, 56kDa(Previous names: docking protein 2, 56kD )
| |
Aliases
for DOK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Docking Protein 2, 56kDa1 2 | | Docking Protein 2, 56kD1 | | P56dok-21 | | Docking Protein 22 | | Downstream Of Tyrosine Kinase 22 3 | | P56DOK5 | | P56(Dok-2)1 | | P56DOK5 | | Dok-21 | | |
Export aliases for DOK2 gene to outside databasesPrevious GC identifers: GC08M021526 GC08M022119 GC08M021788 GC08M020309 |
Summaries
for DOK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DOK2:
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated fromchronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), achimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for theassembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as wellas IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (Bysimilarity)
Gene Wiki entry for DOK2
|
Genomic Views
for DOK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_167187.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DOK2 gene promoter:
Elk-1 NRSF form 1 FOXD1 RelA NRSF form 2 GATA-2 CREB SRY deltaCREB Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DOK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8p21.3 Ensembl cytogenetic band: 8p21.3 HGNC cytogenetic band: 8p21.3DOK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M021822: view genomic region
(about GC identifiers)
Start:
|
21,766,384 bp from pter |
End:
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21,771,371 bp from pter |
Size:
|
4,988 bases |
Orientation:
|
minus strand |
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Proteins
for DOK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496 (See
protein sequence)Recommended Name: Docking protein 2 Size: 412 amino acids; 45379 Da
Subunit: Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) withTEK/TIE2 (tyrosine phosphorylated) (By similarity)
2 PDB 3D structures from  and Proteopedia  for DOK2:2D9W (3D)
2DLW (3D)
Secondary accessions: Q8N5A4Explore the universe of human proteins at neXtProt for DOK2: NX_O60496
Post-translational modifications:
On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is requiredfor binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction withRASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O60496
DOK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003965.2
ENSEMBL proteins: ENSP00000276420 ENSP00000429508 ENSP00000430729 ENSP00000429224 ENSP00000443602 Reactome Protein details: O60496
Human Recombinant Protein Products for DOK2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
DOK2 for ontologies About GeneDecksing
DOK2 Antibody Products:
Assay Products for DOK2: |
Protein
Domains /
Families
for DOK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DOK2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60496ProtoNet protein and cluster: O60496 1 Blocks protein family: IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496Domain: PTB domain mediates receptor interactionSimilarity: Belongs to the DOK family. Type A subfamilySimilarity: Contains 1 IRS-type PTB domainSimilarity: Contains 1 PH domain |
Function
for DOK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DOK2_HUMAN, O60496Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for theassembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as wellas IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (Bysimilarity) Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005057 | receptor signaling protein activity |
IEA | -- | | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity |
IEA | -- | | GO:0005158 | insulin receptor binding |
IEA | -- | | GO:0005543 | phospholipid binding |
IEA | -- |
DOK2 for ontologies About GeneDecksing
Phenotypes:
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dok2):
DOK2 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Dok2tm1Yyam for DOK2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOK2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DOK2 (NM_003974) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK2 |
|
Pathways & Interactions
for DOK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling TC21 regulation pathway | | | 2 | Development EGFR signaling pathway | | | 3 | Development_PDGF signaling via STATs and NF-kB | | | 4 | Development HGF signaling pathway | | | 5 | G-protein signaling K-RAS regulation pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for DOK2 (see all 6)
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DOK2
1 
Cell Signaling Technology (CST) Pathway for DOK2
5/6  GeneGo (Thomson Reuters) Pathways for DOK2 (see all 6)
5  BioSystems Pathways for DOK2
3 
Reactome Pathways for DOK2
DOK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DOK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/46 Interacting proteins for DOK2 (O604962, 3 ENSP000002764204) via UniProtKB, MINT, STRING, and/or I2D (see all 46)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
DOK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DOK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DOK2 for compounds About GeneDecksing
 Browse Tocris compounds for DOK2
2 Novoseek chemical compound relationships for DOK2 gene About this table
Search CenterWatch for drugs/clinical trials and news about DOK2
|
Transcripts
for DOK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DOK2 gene (2 alternative transcripts): NM_003974.2 NM_201349.1 Unigene Cluster for DOK2: Docking protein 2, 56kDa Hs.71215 [show with all ESTs]Unigene Representative Sequence: NM_0039748 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000276420(uc003wzx.1 uc003wzy.1 uc003wzz.1 uc010lth.1)
ENST00000524001 ENST00000517422 ENST00000518197 ENST00000523932 ENST00000522011
ENST00000521910 ENST00000544659
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOK2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DOK2 (NM_003974) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOK2 |
Additional cDNA sequence: AF034970.1 AK226110.1 AK292126.1 AK296671.1 BC032623.1 6 DOTS entries: DT.409458 DT.100777519 DT.100776025 DT.95302807 DT.409459 DT.92416977 24/78 AceView cDNA sequences (see all 78): AA936619 CR602622 AI826859 CR626090 AA380752 NM_201349 NM_003974 BQ073121 CR597117 CA306148 CD369937 CR611181 BX341194 AI300320 BM922360 BM932080 CA439849 CD743150 BQ067133 BM925494 BX348501 BM922480 BQ084451 AA133189
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DOK2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DOK2
|
Expression
for DOK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DOK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGCCAGC
About this image
See DOK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOK2
SOURCE GeneReport for Unigene cluster: Hs.71215
UniProtKB/Swiss-Prot: DOK2_HUMAN, O60496Tissue specificity: Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression inthymus, bone marrow and fetal liver
SABiosciences Expression via Pathway-Focused PCR Array including DOK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK2 |
Orthologs
for DOK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DOK2 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for DOK2 (if available)
TreeFam Gene Tree for DOK2 (if available) |
Paralogs
for DOK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DOK2 gene
- DOK12 DOK32
3 SIMAP similar genes for DOK2 using alignment to 5 protein entries: DOK2_HUMAN (see all proteins):FRS2 DOK1 DOK3
DOK2 for paralogs About GeneDecksing
|
Genomic Variants
for DOK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DOK2 (21766384 - 21771371 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DOK2
2 CNVs: 2746 3726 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOK2 |
|
Disorders
/ Diseases
for DOK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DOK2 for disorders About GeneDecksing
OMIM gene information: 604997
OMIM disorders: --
5  diseases for DOK2: About MalaCardsleukemia acute leukemia alzheimer's disease colorectal cancer
neuronitis
Human Genome Epidemiology (HuGE) Navigator: DOK2 (4 documents)
Export disorders for DOK2 gene to outside databases
|
Publications
for DOK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DOK2 gene, integrated from 9 sources (see all 53):
(articles sorted by number of sources associating them with DOK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins. (PubMed id 9478921)1, 2, 3, 9 Di Cristofano A.... Resh M.D. (1998)
- Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. (PubMed id 14645010)1, 3, 9 Garcia A....Zitzmann N. (2004)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation. (PubMed id 16177091)1, 9 Boulay I....Duplay P. (2005)
- Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase. (PubMed id 14647425)1, 9 Gerard A....Nunes J.A. (2004)
- Essential roles for Dok2 and RasGAP in CD200 receptor -mediated regulation of human myeloid cells. (PubMed id 19786546)1, 9 Mihrshahi R....Brown M.H. (2009)
- All-trans retinoic acid induces p62DOK1 and p56DOK2 expression which enhances induced differentiation and G0 arrest of HL-60 leukemia cells. (PubMed id 16823827)1, 9 Lamkin T.J....Yen A. (2006)
- Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. (PubMed id 19299694)1, 9 Guittard G....NunA"s J.A. (2009)
|
External Searches for DOK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DOK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DOK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DOK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DOK2 gene:
Search GeneIP for patents involving DOK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DOK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for DOK2 | | OriGene shRNA RFP for DOK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOK2 | | | OriGene Protein Over-expression Lysate for DOK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DOK2 | | OriGene 3'-UTR Clone for DOK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DOK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DOK2 | | OriGene Custom Protein Services for DOK2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOK2 |
| |
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| | Antibodies & Assays for DOK2 |
| | | | Search Tocris compounds for DOK2 |
| |  |  |  |  | | | | |
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 | | | DOK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK2 |
|  |  |  |  | | | | ThermoFisher Antibodies for DOK2 |
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