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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DOK1 Gene

protein-coding GIFtS: 63
GCID: GC02P074776

docking protein 1, 62kDa (downstream of tyrosine kinase...

(Previous names: docking protein 1, 62kD (downstream of tyrosine kinase...)

Explore 11 diseases affiliated with
DOK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Docking Protein 1, 62kDa (Downstream Of Tyrosine Kinase 1)¹ ²		P62dok¹
Downstream Of Tyrosine Kinase 1² ³		P62DOK²
P62(Dok)¹		Docking Protein 1²
Pp62¹		Docking Protein 1 (Downstream Of Tyrosine Kinase 1)²
Docking Protein 1, 62kD (Downstream Of Tyrosine Kinase 1)¹

External Ids:	HGNC: 2990¹	Entrez Gene: 1796²	Ensembl: ENSG00000115325⁷	OMIM: 602919⁵	UniProtKB: Q99704³

Export aliases for DOK1 gene to outside databases

Previous GC identifers: GC02P074918 GC02P074988 GC02P074733 GC02P074755 GC02P074756 GC02P074692 GC02P074518

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOK1:

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The

encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes.

Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2010)

UniProtKB/Swiss-Prot: DOK1_HUMAN, Q99704

Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the

assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling

pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3

Gene Wiki entry for DOK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DOK1 gene promoter:
c-Fos STAT1 AP-1 ATF-2 c-Jun E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOK1 promoter sequence

Search SABiosciences Chromatin IP Primers for DOK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13

DOK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOK1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P074776: view genomic region (about GC identifiers)

Start:	74,776,153 bp from pter	End:	74,784,681 bp from pter
Size:	8,529 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOK1_HUMAN, Q99704 (See protein sequence)

Recommended Name: Docking protein 1

Size: 481 amino acids; 52392 Da

Subunit: Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with

phosphorylated ITGB3

Subcellular location: Isoform 1: Cytoplasm

Subcellular location: Isoform 3: Cytoplasm, perinuclear region

1 PDB 3D structure from and Proteopedia for DOK1:

2V76 (3D)

Secondary accessions: O43204 Q53TY2 Q9UHG6

Alternative splicing, Alternative initiation: 3 isoforms: Q99704-1 Q99704-2 Q99704-3 (Produced by alternative initiation at Met-140 of isoform 1. Contains a N-acetylmethionine at position 1)

Explore the universe of human proteins at neXtProt for DOK1: NX_Q99704

Post-translational modifications:

Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity)¹

Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin

signaling pathway¹

Isoform 3 contains a N-acetylmethionine at position 1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99704

DOK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001184189.1 NP_001372.1

ENSEMBL proteins:

ENSP00000387016 ENSP00000233668 ENSP00000344330 ENSP00000393586

Reactome Protein details: Q99704
Human Recombinant Protein Products:

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	Novus Biologicals DOK1 Proteins Novus Biologicals DOK1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DOK1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

DOK1 for ontologies About GeneDecksing

DOK1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DOK1
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	Novus Biologicals DOK1 Antibodies
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	Uscn Antibodies for DOK1
	ThermoFisher Antibodies for DOK1

Assay Products for DOK1:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DOK1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DOK1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DOK1 for domains About GeneDecksing

3 InterPro domains/families:

IPR002404 Insln_rcpt_S1

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q99704

ProtoNet protein and cluster: Q99704

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: DOK1_HUMAN, Q99704

Domain: The PTB domain mediates receptor interaction

Similarity: Belongs to the DOK family. Type A subfamily

Similarity: Contains 1 IRS-type PTB domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DOK1_HUMAN, Q99704

Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the

assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling

pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3

Genatlas biochemistry entry for DOK1:

phosphotyrosylprotein,62kDa,GAP-associated protein-kinase in chronic myelogenic leukemia progenitor cells

miRNA Products:		OriGene 3'-UTR Clone: DOK1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOK1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate DOK1:
		hsa-miR-3128 hsa-miR-3133 hsa-miR-342-3p
		SwitchGear 3'UTR luciferase reporter plasmid: DOK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOK1 (see all 7) OriGene shRNA RFP: DOK1 OriGene siRNA: DOK1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOK1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DOK1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): DOK1 (NM_001381)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DOK1
		Search LifeMap BioReagents cell lines for DOK1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005158	insulin receptor binding	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005543	phospholipid binding	IEA	--

DOK1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DOK1:

Paclitaxel antagonistic effect

Animal Models:
Mouse knock-outs for DOK1: Dok1^tm1Ppp Dok1^tm1Yyam
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dok1):

adipose tissue	cellular	growth/size	hematopoietic system	homeostasis/metabolism
immune system	mortality/aging	respiratory system	tumorigenesis

DOK1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IRS-related events

IRS-related events	1.00	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.90
IRS-mediated signalling	0.98	IGF1R signaling cascade	0.90
Insulin receptor signalling cascade	0.94	PI3K Cascade	0.84
IRS-related events triggered by IGF1R	0.93	Signaling by Insulin receptor	0.74

G-protein signaling TC21 regulation pathway

	G-protein signaling TC21 regulation pathway	1.00			G-protein signaling_M-RAS regulation pathway	0.71
	G-protein signaling_TC21 regulation pathway	1.00			G-protein signaling M-RAS regulation pathway	0.71

Development EGFR signaling pathway

	Development_GDNF family signaling	0.45			GDNF-Family Ligands and Receptor Interactions	0.21
	Development GDNF family signaling	0.45

Signaling events mediated by Stem cell factor receptor (c-Kit)

Signaling events mediated by Stem cell factor receptor (c-Kit)

1.00

Kit Receptor Signaling Pathway

0.37

Development_Dopamine D2 receptor transactivation of EGFR

Chemotaxis_CXCR4 signaling pathway

0.48

Chemotaxis CXCR4 signaling pathway

0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for DOK1

	Chemotaxis CXCR4 signaling pathway
	G-protein signaling M-RAS regulation pathway
	Development GDNF family signaling
	G-protein signaling TC21 regulation pathway
	G-protein signaling H-RAS regulation pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DOK1

	Fc-Gamma-RIIB Signaling in B-Cells
	GDNF-Family Ligands and Receptor Interactions

1 Cell Signaling Technology (CST) Pathway for DOK1

Tyrosine Kinases / Adaptors

5 GeneGo (Thomson Reuters) Pathways for DOK1

	G-protein signaling H-RAS regulation pathway
	G-protein signaling TC21 regulation pathway
	G-protein signaling M-RAS regulation pathway
	Development GDNF family signaling
	Chemotaxis CXCR4 signaling pathway

5/9 BioSystems Pathways for DOK1 (see all 9)

	Kit Receptor Signaling Pathway
	B Cell Receptor Signaling Pathway
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	Signaling events mediated by PTP1B
	BCR signaling pathway

5/11 Reactome Pathways for DOK1 (see all 11)

	PI3K Cascade
	IGF1R signaling cascade
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	Insulin receptor signalling cascade
	IRS-related events

1 Kegg Pathway (Kegg details for DOK1):

Measles

DOK1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DOK1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for DOK1 (Q99704^{1, 2, 3} ENSP00000233668⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2	P04626²^,³, ENSP00000269571⁴	MINT-74511 MINT-74512 I2D: score=2 STRING: ENSP00000269571
PTPN11	Q06124²^,³, ENSP00000340944⁴	MINT-8036392 I2D: score=1 STRING: ENSP00000340944
SH2D1A	O60880²^,³, ENSP00000360181⁴	MINT-8037441 MINT-8037456 I2D: score=4 STRING: ENSP00000360181
ABL1	P00519³, ENSP00000361423⁴	I2D: score=5 STRING: ENSP00000361423
RASA1	P20936³, ENSP00000274376⁴	I2D: score=5 STRING: ENSP00000274376

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	9008160
GO:0007166	cell surface receptor signaling pathway	TAS	10799545
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	TAS	9008160
GO:0007243	intracellular protein kinase cascade	IEA	--
GO:0007265	Ras protein signal transduction	IEA	--

DOK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DOK1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DOK1
4 Novoseek chemical compound relationships for DOK1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	68.9	59	10688886 (5), 14647425 (4), 11551902 (4), 9620604 (3) (see all 25)
phosphotyrosine	53.2	1	16177091 (1)
phosphatidylinositol	25.5	1	10755621 (1)
phenylalanine	19.7	2	11551902 (2)

Search CenterWatch for drugs/clinical trials and news about DOK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DOK1 gene (2 alternative transcripts):

NM_001197260.1 NM_001381.3

Unigene Cluster for DOK1:

Docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Hs.103854 [show with all ESTs]

Unigene Representative Sequence: AK055944

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409429(uc002smr.3) ENST00000485132 ENST00000233668(uc002sms.3 uc010ffo.3 uc002smt.3 uc002smu.3 uc010yrz.2 uc002smw.1)

ENST00000488613 ENST00000340004 ENST00000489958 ENST00000482206 ENST00000474924

ENST00000480318 ENST00000496966 ENST00000475191 ENST00000464613 ENST00000429631

miRNA Products:		OriGene 3'-UTR Clone: DOK1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOK1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate DOK1:
		hsa-miR-3128 hsa-miR-3133 hsa-miR-342-3p
		SwitchGear 3'UTR luciferase reporter plasmid: DOK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOK1

Additional cDNA sequence:

AF035299.1 AF180527.1 AK055944.1 AK127127.1 AK127656.1 AK222883.1 AK296154.1 AK300097.1

AK314678.1 BC111055.1 BC114440.1 BC114497.1 U70987.1

7 DOTS entries:

DT.100781129 DT.309002 DT.120975019 DT.95373231 DT.100781127 DT.92422050 DT.120975036

24/83 AceView cDNA sequences (see all 83):

CR608499 BX094686 BE047000 BE392310 BX358845 U70987 CF126340 NM_001381

CA771296 AU279985 BE672409 CR617916 BM312866 AF180527 CR615375 BQ006371

CR595209 BQ006816 CA770996 AA811324 BX486985 BU145504 BQ635988 BQ694137

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DOK1 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c
SP1:
SP2:											-		-
SP3:									-
SP4:

ECgene alternative splicing isoforms for DOK1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DOK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCAGAATGG

About this image
See DOK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOK1

SOURCE GeneReport for Unigene cluster: Hs.103854

UniProtKB/Swiss-Prot: DOK1_HUMAN, Q99704

Tissue specificity: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated

peripheral blood T-cells

SABiosciences Expression via Pathway-Focused PCR Array including DOK1:

Insulin Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOK1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOK1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DOK1 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DOK1¹	docking protein 1, 62kDa (downstream of tyrosine kinase more	57.46(n) 50.13(a)		430423 XM_427981.3 XP_427981.3
lizard (Anolis carolinensis)	Reptilia	DOK1⁶	--	46(a)	1 ↔ 1	GL343867.1(157196-161799)
African clawed frog (Xenopus laevis)	Amphibia	CA789095.1²	--	75.79(n)		CA789095.1
zebrafish (Danio rerio)	Actinopterygii	dok1b¹	docking protein 1b	52.38(n) 44.24(a)		406361 NM_213088.1 NP_998253.1
fruit fly (Drosophila melanogaster)	Insecta	Dok⁶	Downstream of kinase	13(a)	1 → many	X(7218251-7222839)

ENSEMBL Gene Tree for DOK1 (if available)
TreeFam Gene Tree for DOK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DOK1 gene

DOK3² DOK2²

2 SIMAP similar genes for DOK1 using alignment to 4 protein entries: DOK1_HUMAN (see all proteins):

DOK3 DOK2

DOK1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DOK1
PGOHUM00000242360

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114680296^1,2	F,	--	74774303(+)	`CAGCTA/GATTTT`	2	--	int¹ us2k¹		1		WA	118
rs181325425^1,2		--	74774314(+)	`ATTTTA/TAAAAA`	2	--	us2k¹ int¹		0	--	--	--	--
rs10153592^1,2	C,F,H,	--	74774473(+)	`AAGATC/TTCAGT`	2	--	int¹ us2k¹		9		NS EA NA	1182
rs185400276^1,2		--	74774694(+)	`GTACCA/GAAAGT`	2	--	int¹ us2k¹		0	--	--	--	--
rs188261005^1,2		--	74774751(+)	`AGAAAC/GTGTGA`	2	--	int¹ us2k¹		0	--	--	--	--
rs180931739^1,2		--	74774832(+)	`GGATTC/TCTCAA`	2	--	int¹ us2k¹		0	--	--	--	--
rs146995861^1,2		--	74775377(+)	`CATCAC/TGGCTT`	2	--	us2k¹ int¹		0	--	--	--	--
rs185928057^1,2		--	74775386(+)	`TTTTTC/TATGGC`	2	--	us2k¹ int¹		0	--	--	--	--
rs191975437^1,2		--	74775387(+)	`TTTTTA/GTGGCT`	2	--	int¹ us2k¹		0	--	--	--	--
rs184038057^1,2		--	74775429(+)	`GTAAAC/TGTCAC`	2	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DOK1 (74776153 - 74784681 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DOK1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DOK1 for disorders           About GeneDecksing

OMIM gene information: 602919    OMIM disorders: --

11 diseases for DOK1:    About MalaCards

chronic lymphocytic leukemia lymphocytic leukemia burkitt's lymphoma lymphoproliferative syndrome

stomach cancer measles leukemia lung carcinoma

carcinoma pancreatitis neuronitis

2 Novoseek disease relationships for DOK1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	55.6	2	16823827 (1), 9008160 (1)
tumors	0	1	14647425 (1)

Genetic Association Database (GAD): DOK1
Human Genome Epidemiology (HuGE) Navigator: DOK1 (4 documents)

Export disorders for DOK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DOK1 gene, integrated from 9 sources (see all 95):
(articles sorted by number of sources associating them with DOK1)

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p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. (PubMed id 9008160)^{1, 2, 3, 9} Carpino N.... Clarkson B. (1997)
Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. (PubMed id 11551902)^{1, 2, 9} Wick M.J.... Liu F. (2001)
DOK1 mediates SHP-2 binding to the alphaVbeta3 integr in and thereby regulates insulin-like growth factor I signaling in cultured vas cular smooth muscle cells. (PubMed id 15546884)^{1, 3, 9} Ling Y....Clemmons D.R. (2005)
Targeted mass spectrometric analysis of N-terminally truncated isoforms generated via alternative translation initiation. (PubMed id 19481542)^{1, 2} Kobayashi R.... Vykoukal J. (2009)
An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding. (PubMed id 18156175)^{1, 2} Oxley C.L....Wegener K.L. (2008)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Germline mutations in Dok1 do not predispose to chronic lymphocytic leukemia. (PubMed id 15541476)^{1, 4} Sellick G.S....Houlston R.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PubMed id 12595900)^{1, 2} Favre C....Nunes J.A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1796	HGNC: 2990	AceView: DOK1	Ensembl:ENSG00000115325	euGenes: HUgn1796
ECgene: DOK1	Kegg: 1796	H-InvDB: DOK1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DOK1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DOK1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DOK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DOK1 gene:
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GeneCards and IP:
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