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Aliases for DOK1 Gene

Aliases for DOK1 Gene

  • Docking Protein 1 2 3 5
  • Downstream Of Tyrosine Kinase 1 2 3 4
  • Pp62 3 4
  • Docking Protein 1, 62kDa (Downstream Of Tyrosine Kinase 1) 2
  • Docking Protein 1, 62kD (Downstream Of Tyrosine Kinase 1) 2
  • P62(Dok) 4
  • P62DOK 3

External Ids for DOK1 Gene

Previous GeneCards Identifiers for DOK1 Gene

  • GC02P074918
  • GC02P074988
  • GC02P074733
  • GC02P074755
  • GC02P074756
  • GC02P074692
  • GC02P074776
  • GC02P074518

Summaries for DOK1 Gene

Entrez Gene Summary for DOK1 Gene

  • The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for DOK1 Gene

DOK1 (Docking Protein 1) is a Protein Coding gene. Diseases associated with DOK1 include Leukemia, Chronic Myeloid, Somatic. Among its related pathways are Signaling by PTK6 and Insulin Pathway. GO annotations related to this gene include signal transducer activity, downstream of receptor and insulin receptor binding. An important paralog of this gene is DOK2.

UniProtKB/Swiss-Prot for DOK1 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Gene Wiki entry for DOK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK1 Gene

Genomics for DOK1 Gene

Regulatory Elements for DOK1 Gene

Enhancers for DOK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G074570 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.4 +24.6 24623 4.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF766 CBX5 ZNF207 JUNB DOK1 LBX2-AS1 HTRA2 AUP1 PCGF1 LBX2 TLX2 DQX1 MRPL53 MOGS
GH02G074575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +28.9 28884 3.4 CTCF PKNOX1 MAX CEBPG ZBTB40 EED SMC3 ETV6 CREM ZNF639 DOK1 LOXL3 AUP1 HTRA2 DQX1 TLX2 PCGF1 LBX2 CCDC142 TTC31
GH02G074585 1.2 Ensembl dbSUPER 16.8 +37.4 37396 0.4 ELF3 FOXA2 NFIB MLX ARID4B THRB ZNF48 RAD21 RARA SLC30A9 DOK1 LOXL3 AUP1 HTRA2 TLX2 PCGF1 TTC31 CCDC142 DQX1 LBX2
GH02G074583 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +35.7 35748 1.6 PKNOX1 BACH1 ZNF316 CBX5 FOS NFE2 MAFK CREM NFE2L2 MTA2 LOXL3 DOK1 HTRA2 AUP1 TLX2 PCGF1 CCDC142 TTC31 DQX1 LBX2
GH02G074587 1.1 Ensembl ENCODE 15.8 +39.6 39596 0.4 HDGF RB1 TBL1XR1 WRNIP1 ARID4B ZNF2 RAD21 ZNF143 THAP11 ZNF654 LBX2 DOK1 MRPL53 HTRA2 AUP1 PCGF1 DQX1 LOXL3 CCDC142 TTC31
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOK1 on UCSC Golden Path with GeneCards custom track

Promoters for DOK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119186 795 801 CREB3L1 ZFP64 SIN3A DMAP1 ZNF2 ZNF48 REST SMARCB1 ZNF592 SMARCA4

Genomic Location for DOK1 Gene

Chromosome:
2
Start:
74,548,205 bp from pter
End:
74,557,554 bp from pter
Size:
9,350 bases
Orientation:
Plus strand

Genomic View for DOK1 Gene

Genes around DOK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK1 Gene

Proteins for DOK1 Gene

  • Protein details for DOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99704-DOK1_HUMAN
    Recommended name:
    Docking protein 1
    Protein Accession:
    Q99704
    Secondary Accessions:
    • O43204
    • Q53TY2
    • Q9UHG6

    Protein attributes for DOK1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52392 Da
    Quaternary structure:
    • Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. Interacts with SRMS (via the SH2 and SH3 domains).

    Three dimensional structures from OCA and Proteopedia for DOK1 Gene

    Alternative splice isoforms for DOK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK1 Gene

Post-translational modifications for DOK1 Gene

  • Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOK1 Gene

Domains & Families for DOK1 Gene

Protein Domains for DOK1 Gene

Suggested Antigen Peptide Sequences for DOK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99704

UniProtKB/Swiss-Prot:

DOK1_HUMAN :
  • The PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type A subfamily.
Domain:
  • The PTB domain mediates receptor interaction.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK1: view

No data available for Gene Families for DOK1 Gene

Function for DOK1 Gene

Molecular function for DOK1 Gene

GENATLAS Biochemistry:
phosphotyrosylprotein,62kDa,GAP-associated protein-kinase in chronic myelogenic leukemia progenitor cells
UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Gene Ontology (GO) - Molecular Function for DOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 signal transducer activity, downstream of receptor IEA --
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with DOK1: view
genes like me logo Genes that share phenotypes with DOK1: view

Animal Models for DOK1 Gene

MGI Knock Outs for DOK1:

Animal Model Products

CRISPR Products

miRNA for DOK1 Gene

miRTarBase miRNAs that target DOK1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DOK1
  • Applied Biological Materials Clones for DOK1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK1 Gene

Localization for DOK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOK1 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 3: Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOK1 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23822091
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with DOK1: view

Pathways & Interactions for DOK1 Gene

genes like me logo Genes that share pathways with DOK1: view

SIGNOR curated interactions for DOK1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9008160
GO:0007166 cell surface receptor signaling pathway TAS 10799545
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA,TAS --
GO:0007265 Ras protein signal transduction IEA --
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with DOK1: view

Drugs & Compounds for DOK1 Gene

(2) Drugs for DOK1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DOK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DOK1: view

Transcripts for DOK1 Gene

Unigene Clusters for DOK1 Gene

Docking protein 1, 62kDa (downstream of tyrosine kinase 1):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DOK1
  • Applied Biological Materials Clones for DOK1

Alternative Splicing Database (ASD) splice patterns (SP) for DOK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for DOK1 Gene

GeneLoc Exon Structure for
DOK1
ECgene alternative splicing isoforms for
DOK1

Expression for DOK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK1 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for DOK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.6), Platelet (18.1), and Monocytes (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOK1 Gene



Protein tissue co-expression partners for DOK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DOK1 Gene:

DOK1

SOURCE GeneReport for Unigene cluster for DOK1 Gene:

Hs.103854

mRNA Expression by UniProt/SwissProt for DOK1 Gene:

Q99704-DOK1_HUMAN
Tissue specificity: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.

Evidence on tissue expression from TISSUES for DOK1 Gene

  • Blood(4.4)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with DOK1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DOK1 Gene

Orthologs for DOK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK1 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia DOK1 34 35
  • 88.77 (n)
dog
(Canis familiaris)
Mammalia DOK1 34 35
  • 87.94 (n)
rat
(Rattus norvegicus)
Mammalia Dok1 34
  • 83.82 (n)
mouse
(Mus musculus)
Mammalia Dok1 34 16 35
  • 83.47 (n)
oppossum
(Monodelphis domestica)
Mammalia DOK1 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK1 35
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOK1 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730410 34
  • 56.62 (n)
zebrafish
(Danio rerio)
Actinopterygii dok1b 34 35
  • 53.61 (n)
dok1a 35
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dok 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 35
  • 25 (a)
OneToMany
Species where no ortholog for DOK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK1 Gene

ENSEMBL:
Gene Tree for DOK1 (if available)
TreeFam:
Gene Tree for DOK1 (if available)

Paralogs for DOK1 Gene

Paralogs for DOK1 Gene

(2) SIMAP similar genes for DOK1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DOK1 Gene

genes like me logo Genes that share paralogs with DOK1: view

Variants for DOK1 Gene

Sequence variations from dbSNP and Humsavar for DOK1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs41295954 Uncertain significance 74,556,738(+) CCCCA(A/G)AGAGG upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs146972503 Benign 74,552,556(+) GGACG(C/G)AGACC intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000411198 -- 74,549,094(+) CGCGC(A/G)CCCCG intron-variant, utr-variant-5-prime
rs1000548501 -- 74,548,678(+) GTAGA(C/T)GTTCC intron-variant, upstream-variant-2KB
rs1001007749 -- 74,552,979(+) AGGAT(A/G)TGAGA intron-variant, upstream-variant-2KB

Variation tolerance for DOK1 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DOK1 Gene

Disorders for DOK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DOK1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, chronic myeloid, somatic
  • leukemia, chronic myeloid
- elite association - COSMIC cancer census association via MalaCards
Search DOK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DOK1

Genetic Association Database (GAD)
DOK1
Human Genome Epidemiology (HuGE) Navigator
DOK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK1
genes like me logo Genes that share disorders with DOK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOK1 Gene

Publications for DOK1 Gene

  1. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. (PMID: 9008160) Carpino N. … Clarkson B. (Cell 1997) 2 3 4 22 64
  2. DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. (PMID: 15546884) Ling Y. … Clemmons D.R. (J. Biol. Chem. 2005) 2 3 22 64
  3. Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. (PMID: 11551902) Wick M.J. … Liu F. (J. Biol. Chem. 2001) 3 4 22 64
  4. The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1. (PMID: 23822091) Goel R.K. … Lukong K.E. (FEBS J. 2013) 3 4 64
  5. Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. (PMID: 19299694) Guittard G. … NunA"s J.A. (J. Immunol. 2009) 3 22 64

Products for DOK1 Gene

  • Addgene plasmids for DOK1

Sources for DOK1 Gene

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