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Aliases for DOK1 Gene

Aliases for DOK1 Gene

  • Docking Protein 1 2 3 5
  • Downstream Of Tyrosine Kinase 1 2 3 4
  • Docking Protein 1, 62kDa (Downstream Of Tyrosine Kinase 1) 2 3
  • Pp62 3 4
  • Docking Protein 1, 62kD (Downstream Of Tyrosine Kinase 1) 2
  • Docking Protein 1 (Downstream Of Tyrosine Kinase 1) 3
  • P62(Dok) 4
  • P62DOK 3

External Ids for DOK1 Gene

Previous GeneCards Identifiers for DOK1 Gene

  • GC02P074918
  • GC02P074988
  • GC02P074733
  • GC02P074755
  • GC02P074756
  • GC02P074692
  • GC02P074776
  • GC02P074518

Summaries for DOK1 Gene

Entrez Gene Summary for DOK1 Gene

  • The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for DOK1 Gene

DOK1 (Docking Protein 1) is a Protein Coding gene. Diseases associated with DOK1 include leukemia, chronic myeloid, somatic. Among its related pathways are Signaling by GPCR and Kit Receptor Signaling Pathway. GO annotations related to this gene include receptor signaling protein activity and insulin receptor binding. An important paralog of this gene is DOK5.

UniProtKB/Swiss-Prot for DOK1 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Gene Wiki entry for DOK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK1 Gene

Genomics for DOK1 Gene

Regulatory Elements for DOK1 Gene

Promoters for DOK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DOK1 Gene

Chromosome:
2
Start:
74,548,205 bp from pter
End:
74,557,554 bp from pter
Size:
9,350 bases
Orientation:
Plus strand

Genomic View for DOK1 Gene

Genes around DOK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK1 Gene

Proteins for DOK1 Gene

  • Protein details for DOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99704-DOK1_HUMAN
    Recommended name:
    Docking protein 1
    Protein Accession:
    Q99704
    Secondary Accessions:
    • O43204
    • Q53TY2
    • Q9UHG6

    Protein attributes for DOK1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52392 Da
    Quaternary structure:
    • Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. Interacts with SRMS (via the SH2 and SH3 domains).

    Three dimensional structures from OCA and Proteopedia for DOK1 Gene

    Alternative splice isoforms for DOK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK1 Gene

Proteomics data for DOK1 Gene at MOPED

Post-translational modifications for DOK1 Gene

  • Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
  • Isoform 3 contains a N-acetylmethionine at position 1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DOK1 (DOK1)

No data available for DME Specific Peptides for DOK1 Gene

Domains & Families for DOK1 Gene

Protein Domains for DOK1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DOK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99704

UniProtKB/Swiss-Prot:

DOK1_HUMAN :
  • The PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type A subfamily.
Domain:
  • The PTB domain mediates receptor interaction.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK1: view

No data available for Gene Families for DOK1 Gene

Function for DOK1 Gene

Molecular function for DOK1 Gene

GENATLAS Biochemistry:
phosphotyrosylprotein,62kDa,GAP-associated protein-kinase in chronic myelogenic leukemia progenitor cells
UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
genes like me logo Genes that share phenotypes with DOK1: view

Animal Models for DOK1 Gene

MGI Knock Outs for DOK1:

Animal Model Products

miRNA for DOK1 Gene

miRTarBase miRNAs that target DOK1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK1 Gene

Localization for DOK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOK1 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 3: Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOK1 Gene COMPARTMENTS Subcellular localization image for DOK1 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DOK1 Gene

Pathways & Interactions for DOK1 Gene

genes like me logo Genes that share pathways with DOK1: view

SIGNOR curated interactions for DOK1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 10799545
genes like me logo Genes that share ontologies with DOK1: view

Drugs & Compounds for DOK1 Gene

(2) Drugs for DOK1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DOK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DOK1: view

Transcripts for DOK1 Gene

Unigene Clusters for DOK1 Gene

Docking protein 1, 62kDa (downstream of tyrosine kinase 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for DOK1 Gene

GeneLoc Exon Structure for
DOK1
ECgene alternative splicing isoforms for
DOK1

Expression for DOK1 Gene

mRNA expression in normal human tissues for DOK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK1 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for DOK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (30.6), Platelet (18.1), and Monocytes (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOK1 Gene



SOURCE GeneReport for Unigene cluster for DOK1 Gene Hs.103854

mRNA Expression by UniProt/SwissProt for DOK1 Gene

Q99704-DOK1_HUMAN
Tissue specificity: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
genes like me logo Genes that share expression patterns with DOK1: view

Protein tissue co-expression partners for DOK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for DOK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK1 36
  • 100 (a)
OneToOne
DOK1 35
  • 99.58 (n)
  • 99.58 (a)
cow
(Bos Taurus)
Mammalia DOK1 35
  • 88.77 (n)
  • 88.15 (a)
DOK1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOK1 36
  • 88 (a)
OneToOne
DOK1 35
  • 87.94 (n)
  • 88.36 (a)
mouse
(Mus musculus)
Mammalia Dok1 16
Dok1 36
  • 84 (a)
OneToOne
Dok1 35
  • 83.47 (n)
  • 83.96 (a)
oppossum
(Monodelphis domestica)
Mammalia DOK1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dok1 35
  • 83.82 (n)
  • 84.37 (a)
chicken
(Gallus gallus)
Aves DOK1 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOK1 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730410 35
  • 56.62 (n)
  • 54.59 (a)
zebrafish
(Danio rerio)
Actinopterygii dok1b 35
  • 53.61 (n)
  • 45.5 (a)
dok1a 36
  • 26 (a)
OneToMany
dok1b 36
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dok 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 36
  • 25 (a)
OneToMany
Species with no ortholog for DOK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK1 Gene

ENSEMBL:
Gene Tree for DOK1 (if available)
TreeFam:
Gene Tree for DOK1 (if available)

Paralogs for DOK1 Gene

Paralogs for DOK1 Gene

(2) SIMAP similar genes for DOK1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DOK1 Gene

genes like me logo Genes that share paralogs with DOK1: view

Variants for DOK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DOK1 Gene

Variant ID Type Subtype PubMed ID
dgv4166n71 CNV Loss 21882294

Variation tolerance for DOK1 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOK1 Gene

HapMap Linkage Disequilibrium report
DOK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DOK1 Gene

Disorders for DOK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DOK1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
leukemia, chronic myeloid, somatic
  • chronic myeloid leukemia
- elite association - COSMIC cancer census association via MalaCards
Search DOK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DOK1

Genetic Association Database (GAD)
DOK1
Human Genome Epidemiology (HuGE) Navigator
DOK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOK1
genes like me logo Genes that share disorders with DOK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOK1 Gene

Publications for DOK1 Gene

  1. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. (PMID: 9008160) Carpino N. … Clarkson B. (Cell 1997) 2 3 4 23 67
  2. DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. (PMID: 15546884) Ling Y. … Clemmons D.R. (J. Biol. Chem. 2005) 2 3 23
  3. Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PMID: 19682241) Senis Y.A. … GarcA-a A. (J. Thromb. Haemost. 2009) 3 23
  4. Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells. (PMID: 19299694) Guittard G. … NunA"s J.A. (J. Immunol. 2009) 3 23
  5. All-trans retinoic acid induces p62DOK1 and p56DOK2 expression which enhances induced differentiation and G0 arrest of HL-60 leukemia cells. (PMID: 16823827) Lamkin T.J. … Yen A. (Am. J. Hematol. 2006) 3 23

Products for DOK1 Gene

Sources for DOK1 Gene

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