Aliases for DOK1 Gene
External Ids for DOK1 Gene
Previous GeneCards Identifiers for DOK1 Gene
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
GeneCards Summary for DOK1 Gene
DOK1 (Docking Protein 1, 62kDa (Downstream Of Tyrosine Kinase 1)) is a Protein Coding gene. Diseases associated with DOK1 include leukemia, chronic myeloid, somatic. Among its related pathways are Tyrosine Kinases / Adaptors and Signaling events mediated by PTP1B. GO annotations related to this gene include receptor signaling protein activity and insulin receptor binding. An important paralog of this gene is DOK5.
UniProtKB/Swiss-Prot for DOK1 Gene
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.