Aliases for DOK1 Gene
External Ids for DOK1 Gene
Previous GeneCards Identifiers for DOK1 Gene
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
GeneCards Summary for DOK1 Gene
DOK1 (Docking Protein 1) is a Protein Coding gene. Diseases associated with DOK1 include Leukemia, Chronic Myeloid, Somatic. Among its related pathways are RET signaling and G-protein signaling_H-RAS regulation pathway. GO annotations related to this gene include signal transducer activity, downstream of receptor and insulin receptor binding. An important paralog of this gene is DOK2.
UniProtKB/Swiss-Prot for DOK1 Gene
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.