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Aliases for DOK1 Gene

Aliases for DOK1 Gene

  • Docking Protein 1, 62kDa (Downstream Of Tyrosine Kinase 1) 2 3
  • Downstream Of Tyrosine Kinase 1 3 4
  • P62(Dok) 3 4
  • Pp62 3 4
  • Docking Protein 1, 62kD (Downstream Of Tyrosine Kinase 1) 2
  • Docking Protein 1 (Downstream Of Tyrosine Kinase 1) 3
  • Docking Protein 1 3
  • P62DOK 3

External Ids for DOK1 Gene

Previous GeneCards Identifiers for DOK1 Gene

  • GC02P074918
  • GC02P074988
  • GC02P074733
  • GC02P074755
  • GC02P074756
  • GC02P074692
  • GC02P074776
  • GC02P074518

Summaries for DOK1 Gene

Entrez Gene Summary for DOK1 Gene

  • The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

GeneCards Summary for DOK1 Gene

DOK1 (Docking Protein 1, 62kDa (Downstream Of Tyrosine Kinase 1)) is a Protein Coding gene. Diseases associated with DOK1 include stomach cancer. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include phospholipid binding and insulin receptor binding. An important paralog of this gene is DOK5.

UniProtKB/Swiss-Prot for DOK1 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Gene Wiki entry for DOK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK1 Gene

Genomics for DOK1 Gene

Regulatory Elements for DOK1 Gene

Genomic Location for DOK1 Gene

Start:
74,549,020 bp from pter
End:
74,557,554 bp from pter
Size:
8,535 bases
Orientation:
Plus strand

Genomic View for DOK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK1 Gene

Proteins for DOK1 Gene

  • Protein details for DOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99704-DOK1_HUMAN
    Recommended name:
    Docking protein 1
    Protein Accession:
    Q99704
    Secondary Accessions:
    • O43204
    • Q53TY2
    • Q9UHG6

    Protein attributes for DOK1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52392 Da
    Quaternary structure:
    • Interacts with ABL1 (By similarity). Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. Interacts with SRMS (via the SH2 and SH3 domains).

    Three dimensional structures from OCA and Proteopedia for DOK1 Gene

    Alternative splice isoforms for DOK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK1 Gene

Proteomics data for DOK1 Gene at MOPED

Post-translational modifications for DOK1 Gene

  • Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
  • Isoform 3 contains a N-acetylmethionine at position 1
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DOK1 Gene

Domains for DOK1 Gene

Protein Domains for DOK1 Gene

Suggested Antigen Peptide Sequences for DOK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99704

UniProtKB/Swiss-Prot:

DOK1_HUMAN :
  • Q99704
Domain:
  • The PTB domain mediates receptor interaction
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK1: view

No data available for Gene Families for DOK1 Gene

Function for DOK1 Gene

Molecular function for DOK1 Gene

GENATLAS Biochemistry: phosphotyrosylprotein,62kDa,GAP-associated protein-kinase in chronic myelogenic leukemia progenitor cells
UniProtKB/Swiss-Prot Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Gene Ontology (GO) - Molecular Function for DOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005158 insulin receptor binding IEA --
GO:0005515 protein binding IPI 16273093
genes like me logo Genes that share ontologies with DOK1: view
genes like me logo Genes that share phenotypes with DOK1: view

Animal Models for DOK1 Gene

MGI Knock Outs for DOK1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DOK1 Gene

Localization for DOK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOK1 Gene

Isoform 1: Cytoplasm. Nucleus.
Isoform 3: Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOK1 Gene COMPARTMENTS Subcellular localization image for DOK1 gene
Compartment Confidence
cytosol 4
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23822091
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with DOK1: view

Pathways for DOK1 Gene

genes like me logo Genes that share pathways with DOK1: view

Gene Ontology (GO) - Biological Process for DOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 10799545
GO:0007166 cell surface receptor signaling pathway TAS 10799545
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 9008160
GO:0007265 Ras protein signal transduction IEA --
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with DOK1: view

Compounds for DOK1 Gene

(4) Novoseek inferred chemical compound relationships for DOK1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 68.9 46
phosphotyrosine 53.2 1
phosphatidylinositol 25.5 1
phenylalanine 19.7 2
genes like me logo Genes that share compounds with DOK1: view

Transcripts for DOK1 Gene

Unigene Clusters for DOK1 Gene

Docking protein 1, 62kDa (downstream of tyrosine kinase 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1:
SP2: - -
SP3: -
SP4:

Relevant External Links for DOK1 Gene

GeneLoc Exon Structure for
DOK1
ECgene alternative splicing isoforms for
DOK1

Expression for DOK1 Gene

mRNA expression in normal human tissues for DOK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOK1 Gene

This gene is overexpressed in Whole Blood (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOK1 Gene

SOURCE GeneReport for Unigene cluster for DOK1 Gene Hs.103854

mRNA Expression by UniProt/SwissProt for DOK1 Gene

Q99704-DOK1_HUMAN
Tissue specificity: Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
genes like me logo Genes that share expressions with DOK1: view

Orthologs for DOK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOK1 35
  • 99.58 (n)
  • 99.58 (a)
DOK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DOK1 35
  • 88.77 (n)
  • 88.15 (a)
DOK1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOK1 35
  • 87.94 (n)
  • 88.36 (a)
DOK1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dok1 35
  • 83.47 (n)
  • 83.96 (a)
Dok1 16
Dok1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOK1 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dok1 35
  • 83.82 (n)
  • 84.37 (a)
chicken
(Gallus gallus)
Aves DOK1 36
  • 33 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOK1 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730410 35
  • 56.62 (n)
  • 54.59 (a)
zebrafish
(Danio rerio)
Actinopterygii dok1a 36
  • 26 (a)
OneToMany
dok1b 35
  • 53.61 (n)
  • 45.5 (a)
dok1b 36
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dok 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 36
  • 25 (a)
OneToMany
Species with no ortholog for DOK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK1 Gene

ENSEMBL:
Gene Tree for DOK1 (if available)
TreeFam:
Gene Tree for DOK1 (if available)

Paralogs for DOK1 Gene

Paralogs for DOK1 Gene

Selected SIMAP similar genes for DOK1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for DOK1 Gene

genes like me logo Genes that share paralogs with DOK1: view

Variants for DOK1 Gene

Sequence variations from dbSNP and Humsavar for DOK1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10194923 -- 74,557,286(+) GTCCT(A/G)AGAAG utr-variant-3-prime, downstream-variant-500B
rs11554781 -- 74,557,322(-) ATGCA(A/G)AGCCC utr-variant-3-prime, downstream-variant-500B
rs41295954 -- 74,556,738(+) CCCCA(A/G)AGAGG reference, missense, utr-variant-3-prime
rs41305594 -- 74,557,381(+) GGGAC(C/T)AGGTC utr-variant-3-prime, downstream-variant-500B
rs78483803 -- 74,556,892(+) GATGA(A/C)TACGC missense, reference, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DOK1 Gene

Variant ID Type Subtype PubMed ID
dgv4166n71 CNV Loss 21882294

Relevant External Links for DOK1 Gene

HapMap Linkage Disequilibrium report
DOK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK1 Gene

Disorders for DOK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DOK1 Gene including...

Search for DOK1 Gene in MalaCards »

(2) Novoseek inferred disease relationships for DOK1 Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia chronic 55.6 2
tumors 0 1

Relevant External Links for DOK1

Genetic Association Database (GAD)
DOK1
Human Genome Epidemiology (HuGE) Navigator
DOK1
genes like me logo Genes that share disorders with DOK1: view

No data available for UniProtKB/Swiss-Prot for DOK1 Gene

Publications for DOK1 Gene

  1. p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. (PMID: 9008160) Carpino N. … Clarkson B. (Cell 1997) 2 3 4 23
  2. Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. (PMID: 11551902) Wick M.J. … Liu F. (J. Biol. Chem. 2001) 3 4 23
  3. DOK1 mediates SHP-2 binding to the alphaVbeta3 integrin and thereby regulates insulin-like growth factor I signaling in cultured vascular smooth muscle cells. (PMID: 15546884) Ling Y. … Clemmons D.R. (J. Biol. Chem. 2005) 2 3 23
  4. IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation. (PMID: 15574499) Lee S. … Sylla B.S. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 23
  5. Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation. (PMID: 16177091) Boulay I. … Duplay P. (J. Immunol. 2005) 3 23

Products for DOK1 Gene

Sources for DOK1 Gene

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