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Aliases for DOHH Gene

Aliases for DOHH Gene

  • Deoxyhypusine Hydroxylase/Monooxygenase 2 3
  • HLRC1 3 4 6
  • HEAT-Like (PBS Lyase) Repeat Containing 1 2 3
  • HEAT-Like Repeat-Containing Protein 1 3 4
  • Deoxyhypusine Monooxygenase 3 4
  • Deoxyhypusine Dioxygenase 3 4
  • EC 1.14.99.29 4 63
  • HDOHH 3 4
  • Deoxyhypusine Hydroxylase 3

External Ids for DOHH Gene

Previous HGNC Symbols for DOHH Gene

  • HLRC1

Previous GeneCards Identifiers for DOHH Gene

  • GC19M003443
  • GC19M003256

Summaries for DOHH Gene

Entrez Gene Summary for DOHH Gene

  • This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for DOHH Gene

DOHH (Deoxyhypusine Hydroxylase/Monooxygenase) is a Protein Coding gene. Diseases associated with DOHH include actinomycosis. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include deoxyhypusine monooxygenase activity.

UniProtKB/Swiss-Prot for DOHH Gene

  • Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOHH Gene

Genomics for DOHH Gene

Regulatory Elements for DOHH Gene

Genomic Location for DOHH Gene

Start:
3,490,821 bp from pter
End:
3,500,940 bp from pter
Size:
10,120 bases
Orientation:
Minus strand

Genomic View for DOHH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOHH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOHH Gene

Proteins for DOHH Gene

  • Protein details for DOHH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU89-DOHH_HUMAN
    Recommended name:
    Deoxyhypusine hydroxylase
    Protein Accession:
    Q9BU89
    Secondary Accessions:
    • O75265

    Protein attributes for DOHH Gene

    Size:
    302 amino acids
    Molecular mass:
    32904 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 2 Fe(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for DOHH Gene

Proteomics data for DOHH Gene at MOPED

Post-translational modifications for DOHH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOHH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DOHH Gene

Suggested Antigen Peptide Sequences for DOHH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU89

UniProtKB/Swiss-Prot:

DOHH_HUMAN :
  • Q9BU89
Family:
  • Belongs to the deoxyhypusine hydroxylase family.
Similarity:
  • Contains 5 HEAT-like PBS-type repeats.
genes like me logo Genes that share domains with DOHH: view

No data available for Gene Families for DOHH Gene

Function for DOHH Gene

Molecular function for DOHH Gene

UniProtKB/Swiss-Prot CatalyticActivity: [eIF5A]-deoxyhypusine + AH(2) + O(2) = [eIF5A]-hypusine + A + H(2)O.
UniProtKB/Swiss-Prot Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Enzyme Numbers (IUBMB) for DOHH Gene

Gene Ontology (GO) - Molecular Function for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17213197
GO:0019135 deoxyhypusine monooxygenase activity TAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DOHH: view

miRNA for DOHH Gene

miRTarBase miRNAs that target DOHH

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DOHH Gene

Localization for DOHH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOHH Gene COMPARTMENTS Subcellular localization image for DOHH gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOHH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOHH Gene

Pathways for DOHH Gene

genes like me logo Genes that share pathways with DOHH: view

UniProtKB/Swiss-Prot Q9BU89-DOHH_HUMAN

  • Pathway: Protein modification; eIF5A hypusination.

Gene Ontology (GO) - Biological Process for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DOHH: view

Compounds for DOHH Gene

(3) HMDB Compounds for DOHH Gene

Compound Synonyms Cas Number PubMed IDs
Deoxyhypusine
  • N(6)-(4-Aminobutyl)lysine
82543-85-9
Oxygen
  • Oxygen
7782-44-7
Water
  • Dihydrogen oxide
7732-18-5
genes like me logo Genes that share compounds with DOHH: view

Transcripts for DOHH Gene

Unigene Clusters for DOHH Gene

Deoxyhypusine hydroxylase/monooxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOHH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for DOHH Gene

GeneLoc Exon Structure for
DOHH
ECgene alternative splicing isoforms for
DOHH

Expression for DOHH Gene

mRNA expression in normal human tissues for DOHH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOHH Gene

SOURCE GeneReport for Unigene cluster for DOHH Gene Hs.515064

genes like me logo Genes that share expressions with DOHH: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DOHH Gene

Orthologs for DOHH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOHH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOHH 35
  • 98.68 (n)
  • 98.34 (a)
DOHH 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DOHH 35
  • 85.51 (n)
  • 88.96 (a)
DOHH 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOHH 36
  • 86 (a)
OneToOne
LOC485060 35
  • 88.82 (n)
  • 88.04 (a)
mouse
(Mus musculus)
Mammalia Dohh 35
  • 80.62 (n)
  • 85.05 (a)
Dohh 16
Dohh 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOHH 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOHH 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dohh 35
  • 78.18 (n)
  • 83.39 (a)
chicken
(Gallus gallus)
Aves DOHH 35
  • 74.61 (n)
  • 75.17 (a)
DOHH 36
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8013 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145112 35
  • 63.59 (n)
  • 69.62 (a)
Str.7532 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11146 35
zebrafish
(Danio rerio)
Actinopterygii dohh 35
  • 63 (n)
  • 67 (a)
dohh 36
  • 65 (a)
OneToOne
wufb33c04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002129 35
  • 62.68 (n)
  • 60.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta nero 35
  • 61.62 (n)
  • 59.26 (a)
nero 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dohh-1 35
  • 55.44 (n)
  • 58.33 (a)
dohh-1 36
  • 56 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR426C 35
  • 58.12 (n)
  • 49.44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LIA1 35
  • 50.98 (n)
  • 52.21 (a)
LIA1 36
  • 44 (a)
OneToOne
LIA1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14080g 35
  • 50.61 (n)
  • 51.82 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58180 35
  • 50.9 (n)
  • 53.43 (a)
rice
(Oryza sativa)
Liliopsida Os12g0626100 35
  • 52.35 (n)
  • 51.99 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05252 35
  • 56.26 (n)
  • 49.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mmd1 35
  • 47.37 (n)
  • 48.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for DOHH:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOHH Gene

ENSEMBL:
Gene Tree for DOHH (if available)
TreeFam:
Gene Tree for DOHH (if available)

Paralogs for DOHH Gene

No data available for Paralogs for DOHH Gene

Variants for DOHH Gene

Sequence variations from dbSNP and Humsavar for DOHH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10126 -- 3,491,370(-) GCGCA(C/T)GGTTG utr-variant-3-prime
rs1051803 -- 3,490,910(+) CCCAC(C/T)CAGGG utr-variant-3-prime
rs1051808 -- 3,492,342(+) GCGGC(C/T)GGGAC missense, reference
rs2286440 -- 3,490,953(+) TGGGG(A/G)AGTCA utr-variant-3-prime
rs4806940 -- 3,502,307(+) ggcct(A/G)gtggc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DOHH Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3653n71 CNV Loss 21882294
nsv526602 CNV Loss 19592680
dgv3654n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294

Relevant External Links for DOHH Gene

HapMap Linkage Disequilibrium report
DOHH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOHH Gene

Disorders for DOHH Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DOHH Gene including...

Search for DOHH Gene in MalaCards »

(1) University of Copenhagen DISEASES for DOHH Gene

genes like me logo Genes that share disorders with DOHH: view

No data available for UniProtKB/Swiss-Prot for DOHH Gene

Publications for DOHH Gene

  1. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PMID: 16371467) Park J.-H. … Park M.H. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4
  2. Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis. (PMID: 16533814) Kim Y.S. … Park M.H. (J. Biol. Chem. 2006) 2 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O(2) with a nonheme diiron center. (PMID: 19706422) Vu V.V. … Que L. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4

Products for DOHH Gene

Sources for DOHH Gene

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