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Aliases for DOHH Gene

Aliases for DOHH Gene

  • Deoxyhypusine Hydroxylase 2 3 5
  • HEAT-Like (PBS Lyase) Repeat Containing 1 2 3
  • Deoxyhypusine Hydroxylase/Monooxygenase 2 3
  • HEAT-Like Repeat-Containing Protein 1 3 4
  • Deoxyhypusine Monooxygenase 3 4
  • Deoxyhypusine Dioxygenase 3 4
  • EC 1.14.99.29 4 58
  • HLRC1 3 4
  • HDOHH 3 4

External Ids for DOHH Gene

Previous HGNC Symbols for DOHH Gene

  • HLRC1

Previous GeneCards Identifiers for DOHH Gene

  • GC19M003443
  • GC19M003256

Summaries for DOHH Gene

Entrez Gene Summary for DOHH Gene

  • This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for DOHH Gene

DOHH (Deoxyhypusine Hydroxylase) is a Protein Coding gene. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Metabolism of proteins. GO annotations related to this gene include binding and deoxyhypusine monooxygenase activity.

UniProtKB/Swiss-Prot for DOHH Gene

  • Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Additional gene information for DOHH Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOHH Gene

Genomics for DOHH Gene

Regulatory Elements for DOHH Gene

Enhancers for DOHH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H003502 1.4 FANTOM5 ENCODE dbSUPER 13.1 +3.0 2984 0 GTF2F1 FOXA2 SAP130 TAL1 IRF9 ZNF664 TCF12 ZNF316 CTBP1 FOXK2 DOHH TLE2 FZR1 S1PR4 GC19P003503
GH19H003499 1.1 ENCODE 14.5 +5.3 5292 1 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CACTIN-AS1 CACTIN ENSG00000267030 CCDC94 ZNF77 APBA3 ENSG00000266959 LOC105372244 ENSG00000267063 DOHH
GH19H003484 0.8 FANTOM5 10.4 +20.8 20803 0 BCOR CTCF PTBP1 ZNF76 ZMYM3 ZNF384 ZBTB7B RAD21 ZFHX2 PATZ1 CACTIN ZNF77 CCDC94 DOHH CACTIN-AS1 ENSG00000284638 GC19P003497
GH19H003386 1.5 Ensembl ENCODE dbSUPER 4.8 +117.3 117337 4 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 TCF12 ATF7 NCOA1 NFIC SMIM24 DOHH ENSG00000279599
GH19H003345 1.2 Ensembl ENCODE dbSUPER 5.3 +159.2 159193 1 ZNF740 MAX MNT REST NR3C1 RAD21 NR2F2 GABPA YY1 ZFHX2 DOHH ENSG00000280103 NFIC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOHH on UCSC Golden Path with GeneCards custom track

Promoters for DOHH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106060 -582 2201 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for DOHH Gene

Chromosome:
19
Start:
3,490,821 bp from pter
End:
3,505,918 bp from pter
Size:
15,098 bases
Orientation:
Minus strand

Genomic View for DOHH Gene

Genes around DOHH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOHH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOHH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOHH Gene

Proteins for DOHH Gene

  • Protein details for DOHH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU89-DOHH_HUMAN
    Recommended name:
    Deoxyhypusine hydroxylase
    Protein Accession:
    Q9BU89
    Secondary Accessions:
    • O75265

    Protein attributes for DOHH Gene

    Size:
    302 amino acids
    Molecular mass:
    32904 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DOHH Gene

neXtProt entry for DOHH Gene

Selected DME Specific Peptides for DOHH Gene

Q9BU89:
  • SALLKHE
  • ESCEVALDM
  • RYRAMFALR
  • EVAETCQLAV
  • SVDPAPP
  • QPLQARFRALFTLRGLGGP
  • EAALALAEGL
  • PLFERYRAMF

Post-translational modifications for DOHH Gene

  • Ubiquitination at isoforms=18
  • Modification sites at PhosphoSitePlus

Other Protein References for DOHH Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DOHH Gene

Gene Families for DOHH Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DOHH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU89

UniProtKB/Swiss-Prot:

DOHH_HUMAN :
  • Belongs to the deoxyhypusine hydroxylase family.
Family:
  • Belongs to the deoxyhypusine hydroxylase family.
genes like me logo Genes that share domains with DOHH: view

Function for DOHH Gene

Molecular function for DOHH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[eIF5A]-deoxyhypusine + AH(2) + O(2) = [eIF5A]-hypusine + A + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Enzyme Numbers (IUBMB) for DOHH Gene

Gene Ontology (GO) - Molecular Function for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17213197
GO:0016491 oxidoreductase activity IEA --
GO:0019135 deoxyhypusine monooxygenase activity EXP,IMP 16371467
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DOHH: view
genes like me logo Genes that share phenotypes with DOHH: view

Animal Models for DOHH Gene

MGI Knock Outs for DOHH:

Animal Model Products

CRISPR Products

miRNA for DOHH Gene

miRTarBase miRNAs that target DOHH

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOHH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOHH Gene

Localization for DOHH Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOHH gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOHH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOHH Gene

Pathways & Interactions for DOHH Gene

genes like me logo Genes that share pathways with DOHH: view

UniProtKB/Swiss-Prot Q9BU89-DOHH_HUMAN

  • Pathway: Protein modification; eIF5A hypusination.

Interacting Proteins for DOHH Gene

Gene Ontology (GO) - Biological Process for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DOHH: view

No data available for SIGNOR curated interactions for DOHH Gene

Drugs & Compounds for DOHH Gene

(2) Drugs for DOHH Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(1) Additional Compounds for DOHH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
deoxyhypusine
  • N(6)-(4-Aminobutyl)-L-lysine
  • N(6)-(4-Aminobutyl)lysine
82543-85-9
genes like me logo Genes that share compounds with DOHH: view

Transcripts for DOHH Gene

mRNA/cDNA for DOHH Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(105) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOHH Gene

Deoxyhypusine hydroxylase/monooxygenase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DOHH
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DOHH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for DOHH Gene

GeneLoc Exon Structure for
DOHH
ECgene alternative splicing isoforms for
DOHH

Expression for DOHH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOHH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOHH Gene

This gene is overexpressed in Bone (25.5) and Heart (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOHH Gene



NURSA nuclear receptor signaling pathways regulating expression of DOHH Gene:

DOHH

SOURCE GeneReport for Unigene cluster for DOHH Gene:

Hs.515064

Evidence on tissue expression from TISSUES for DOHH Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with DOHH: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOHH Gene

Orthologs for DOHH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOHH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOHH 33 34
  • 98.68 (n)
dog
(Canis familiaris)
Mammalia LOC485060 33
  • 88.82 (n)
DOHH 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DOHH 33 34
  • 85.51 (n)
mouse
(Mus musculus)
Mammalia Dohh 33 16 34
  • 80.62 (n)
rat
(Rattus norvegicus)
Mammalia Dohh 33
  • 78.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DOHH 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOHH 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOHH 33 34
  • 74.61 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145112 33
  • 63.59 (n)
Str.7532 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8013 33
zebrafish
(Danio rerio)
Actinopterygii dohh 33 34
  • 63 (n)
wufb33c04 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11146 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002129 33
  • 62.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta nero 33 34
  • 61.62 (n)
worm
(Caenorhabditis elegans)
Secernentea dohh-1 33 34
  • 55.44 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR426C 33
  • 58.12 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LIA1 33 34
  • 50.98 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14080g 33
  • 50.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58180 33
  • 50.9 (n)
rice
(Oryza sativa)
Liliopsida Os12g0626100 33
  • 52.35 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05252 33
  • 56.26 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mmd1 33
  • 47.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
Species where no ortholog for DOHH was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOHH Gene

ENSEMBL:
Gene Tree for DOHH (if available)
TreeFam:
Gene Tree for DOHH (if available)

Paralogs for DOHH Gene

No data available for Paralogs for DOHH Gene

Variants for DOHH Gene

Sequence variations from dbSNP and Humsavar for DOHH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000117459 -- 3,490,724(+) TCCCC(A/G)CCCAG nc-transcript-variant, downstream-variant-500B
rs1000287739 -- 3,493,479(+) GTGGC(A/G)GGCGC intron-variant, downstream-variant-500B
rs1000504124 -- 3,501,736(+) GGATG(A/G)TCGAT upstream-variant-2KB
rs1002030480 -- 3,498,406(+) AATGA(A/T)GGAAT intron-variant
rs1002221408 -- 3,492,366(+) CCTCC(C/G)GCAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DOHH Gene

Variant ID Type Subtype PubMed ID
nsv470114 CNV loss 18288195
nsv526602 CNV loss 19592680
nsv953948 CNV deletion 24416366

Variation tolerance for DOHH Gene

Gene Damage Index Score: 0.82; 17.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOHH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOHH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOHH Gene

Disorders for DOHH Gene

Relevant External Links for DOHH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOHH

No disorders were found for DOHH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOHH Gene

Publications for DOHH Gene

  1. Deoxyhypusine hydroxylase is a Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis [corrected]. (PMID: 16533814) Kim YS … Park MH (The Journal of biological chemistry 2006) 2 3 4 60
  2. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PMID: 16371467) Park JH … Park MH (Proceedings of the National Academy of Sciences of the United States of America 2006) 2 3 4 60
  3. Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O2 with a nonheme diiron center. (PMID: 19706422) Vu VV … Que L (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 60
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for DOHH Gene

Sources for DOHH Gene

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