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Aliases for DOHH Gene

Aliases for DOHH Gene

  • Deoxyhypusine Hydroxylase/Monooxygenase 2 3 5
  • HEAT-Like (PBS Lyase) Repeat Containing 1 2 3
  • HEAT-Like Repeat-Containing Protein 1 3 4
  • Deoxyhypusine Monooxygenase 3 4
  • Deoxyhypusine Dioxygenase 3 4
  • EC 4 63
  • HLRC1 3 4
  • HDOHH 3 4

External Ids for DOHH Gene

Previous HGNC Symbols for DOHH Gene

  • HLRC1

Previous GeneCards Identifiers for DOHH Gene

  • GC19M003443
  • GC19M003256

Summaries for DOHH Gene

Entrez Gene Summary for DOHH Gene

  • This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for DOHH Gene

DOHH (Deoxyhypusine Hydroxylase/Monooxygenase) is a Protein Coding gene. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Transport to the Golgi and subsequent modification. GO annotations related to this gene include binding and deoxyhypusine monooxygenase activity.

UniProtKB/Swiss-Prot for DOHH Gene

  • Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOHH Gene

Genomics for DOHH Gene

Regulatory Elements for DOHH Gene

Enhancers for DOHH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DOHH on UCSC Golden Path with GeneCards custom track

Genomic Location for DOHH Gene

3,490,821 bp from pter
3,505,918 bp from pter
15,098 bases
Minus strand

Genomic View for DOHH Gene

Genes around DOHH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOHH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOHH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOHH Gene

Proteins for DOHH Gene

  • Protein details for DOHH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxyhypusine hydroxylase
    Protein Accession:
    Secondary Accessions:
    • O75265

    Protein attributes for DOHH Gene

    302 amino acids
    Molecular mass:
    32904 Da
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DOHH Gene

neXtProt entry for DOHH Gene

Proteomics data for DOHH Gene at MOPED

Post-translational modifications for DOHH Gene

  • Ubiquitination at Lys 18
  • Modification sites at PhosphoSitePlus

Other Protein References for DOHH Gene

Domains & Families for DOHH Gene

Suggested Antigen Peptide Sequences for DOHH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the deoxyhypusine hydroxylase family.
  • Contains 5 HEAT-like PBS-type repeats.
  • Belongs to the deoxyhypusine hydroxylase family.
  • Contains 5 HEAT-like PBS-type repeats.
genes like me logo Genes that share domains with DOHH: view

No data available for Gene Families for DOHH Gene

Function for DOHH Gene

Molecular function for DOHH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[eIF5A]-deoxyhypusine + AH(2) + O(2) = [eIF5A]-hypusine + A + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Enzyme Numbers (IUBMB) for DOHH Gene

genes like me logo Genes that share phenotypes with DOHH: view

Animal Models for DOHH Gene

MGI Knock Outs for DOHH:

Animal Model Products

miRNA for DOHH Gene

miRTarBase miRNAs that target DOHH

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOHH Gene

Localization for DOHH Gene

Subcellular locations from

Jensen Localization Image for DOHH Gene COMPARTMENTS Subcellular localization image for DOHH gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DOHH Gene

Pathways & Interactions for DOHH Gene

genes like me logo Genes that share pathways with DOHH: view

UniProtKB/Swiss-Prot Q9BU89-DOHH_HUMAN

  • Pathway: Protein modification; eIF5A hypusination.

Gene Ontology (GO) - Biological Process for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine IEA,TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DOHH: view

No data available for SIGNOR curated interactions for DOHH Gene

Drugs & Compounds for DOHH Gene

(3) Additional Compounds for DOHH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • N(6)-(4-Aminobutyl)-L-lysine
  • N(6)-(4-Aminobutyl)lysine
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with DOHH: view

Transcripts for DOHH Gene

Unigene Clusters for DOHH Gene

Deoxyhypusine hydroxylase/monooxygenase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOHH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -

Relevant External Links for DOHH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOHH Gene

mRNA expression in normal human tissues for DOHH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOHH Gene

This gene is overexpressed in Bone (25.5) and Heart (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOHH Gene

SOURCE GeneReport for Unigene cluster for DOHH Gene Hs.515064

genes like me logo Genes that share expression patterns with DOHH: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DOHH Gene

Orthologs for DOHH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOHH Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DOHH 35
  • 85.51 (n)
  • 88.96 (a)
  • 88 (a)
(Canis familiaris)
Mammalia LOC485060 35
  • 88.82 (n)
  • 88.04 (a)
  • 86 (a)
(Mus musculus)
Mammalia Dohh 35
  • 80.62 (n)
  • 85.05 (a)
Dohh 16
Dohh 36
  • 85 (a)
(Pan troglodytes)
Mammalia DOHH 35
  • 98.68 (n)
  • 98.34 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Dohh 35
  • 78.18 (n)
  • 83.39 (a)
(Monodelphis domestica)
Mammalia DOHH 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia DOHH 36
  • 76 (a)
(Gallus gallus)
Aves DOHH 35
  • 74.61 (n)
  • 75.17 (a)
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145112 35
  • 63.59 (n)
  • 69.62 (a)
Str.7532 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8013 35
(Danio rerio)
Actinopterygii dohh 35
  • 63 (n)
  • 67 (a)
wufb33c04 35
dohh 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11146 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002129 35
  • 62.68 (n)
  • 60.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta nero 35
  • 61.62 (n)
  • 59.26 (a)
nero 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea dohh-1 35
  • 55.44 (n)
  • 58.33 (a)
dohh-1 36
  • 56 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR426C 35
  • 58.12 (n)
  • 49.44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14080g 35
  • 50.61 (n)
  • 51.82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LIA1 35
  • 50.98 (n)
  • 52.21 (a)
LIA1 36
  • 44 (a)
LIA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58180 35
  • 50.9 (n)
  • 53.43 (a)
(Oryza sativa)
Liliopsida Os12g0626100 35
  • 52.35 (n)
  • 51.99 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05252 35
  • 56.26 (n)
  • 49.12 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mmd1 35
  • 47.37 (n)
  • 48.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for DOHH:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOHH Gene

Gene Tree for DOHH (if available)
Gene Tree for DOHH (if available)

Paralogs for DOHH Gene

No data available for Paralogs for DOHH Gene

Variants for DOHH Gene

Sequence variations from dbSNP and Humsavar for DOHH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7259349 -- 3,502,983(+) TTTTT(A/T)AAATT intron-variant, upstream-variant-2KB
rs8108177 -- 3,493,597(+) cagag(A/C/T)gagac intron-variant, utr-variant-3-prime
rs1051808 -- 3,492,342(+) GCGGC(C/T)GGGAC reference, missense
rs71339046 -- 3,502,965(+) GCCCA(-/C)CCCCC intron-variant, upstream-variant-2KB
rs72974801 -- 3,503,116(+) TTCCC(C/G)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOHH Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3653n71 CNV Loss 21882294
nsv526602 CNV Loss 19592680
dgv3654n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294

Variation tolerance for DOHH Gene

Gene Damage Index Score: 0.82; 17.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DOHH Gene

Disorders for DOHH Gene

Relevant External Links for DOHH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DOHH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOHH Gene

Publications for DOHH Gene

  1. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PMID: 16371467) Park J.-H. … Park M.H. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 3 4 67
  2. Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis. (PMID: 16533814) Kim Y.S. … Park M.H. (J. Biol. Chem. 2006) 2 3
  3. Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination. (PMID: 25865244) Han Z. … Hilgenfeld R. (Structure 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DOHH Gene

Sources for DOHH Gene