Aliases for DOHH Gene
External Ids for DOHH Gene
Previous HGNC Symbols for DOHH Gene
Previous GeneCards Identifiers for DOHH Gene
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
GeneCards Summary for DOHH Gene
DOHH (Deoxyhypusine Hydroxylase/Monooxygenase) is a Protein Coding gene. Diseases associated with DOHH include actinomycosis. Among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include deoxyhypusine monooxygenase activity.
UniProtKB/Swiss-Prot for DOHH Gene
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.