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DOHH Gene

protein-coding   GIFtS: 53
GCID: GC19M003491

Deoxyhypusine Hydroxylase/Monooxygenase

(Previous name: HEAT-like (PBS lyase) repeat containing 1)
(Previous symbol: HLRC1)
  See DOHH-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxyhypusine Hydroxylase/Monooxygenase1 2     hDOHH2 3
HLRC11 2 3 5     HEAT-Like Repeat-Containing Protein 12 3
HEAT-Like (PBS Lyase) Repeat Containing 11 2     EC 1.14.99.293 8
Deoxyhypusine Dioxygenase2 3     Deoxyhypusine Hydroxylase2
Deoxyhypusine Monooxygenase2 3     

External Ids:    HGNC: 286621   Entrez Gene: 834752   Ensembl: ENSG000001299327   OMIM: 6112625   UniProtKB: Q9BU893   

Export aliases for DOHH gene to outside databases

Previous GC identifers: GC19M003443 GC19M003256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOHH Gene:
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino
acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine
in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, Feb 2009)

GeneCards Summary for DOHH Gene:
DOHH (deoxyhypusine hydroxylase/monooxygenase) is a protein-coding gene. Diseases associated with DOHH include actinomycosis. GO annotations related to this gene include deoxyhypusine monooxygenase activity.

UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an
essential post-translational modification only found in mature eIF-5A factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOHH gene promoter:
         AhR   NRF-2   AP-2gamma   ATF6   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOHH promoter sequence
   Search Chromatin IP Primers for DOHH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOHH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

DOHH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOHH gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003491:  view genomic region     (about GC identifiers)

Start:
3,490,819 bp from pter      End:
3,500,938 bp from pter
Size:
10,120 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89 (See protein sequence)
Recommended Name: Deoxyhypusine hydroxylase  
Size: 302 amino acids; 32904 Da
Cofactor: Binds 2 Fe(2+) ions per subunit
Secondary accessions: O75265

Explore the universe of human proteins at neXtProt for DOHH: NX_Q9BU89

Explore proteomics data for DOHH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DOHH (Q9BU89) (see all 8)
     SALLKHE  SVDPAPP  ESCEVALDM  RYRAMFALR 


    See DOHH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138637.1  NP_112594.1  

    ENSEMBL proteins: 
     ENSP00000250937   ENSP00000464905   ENSP00000468416   ENSP00000398882  
    Reactome Protein details: Q9BU89

    DOHH Human Recombinant Protein Products:

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    Novus Biologicals DOHH Protein
    Novus Biologicals DOHH Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DOHH

     
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    DOHH Antibody Products:

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    Search eBioscience for ELISAs for DOHH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR004155 PBS_lyase_HEAT
     IPR027517 Deoxyhypusine_hydroxylase
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9BU89

    ProtoNet protein and cluster: Q9BU89

    1 Blocks protein domain: IPB004155 PBS lyase HEAT-like repeat

    UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89
    Similarity: Belongs to the deoxyhypusine hydroxylase family
    Similarity: Contains 5 HEAT-like PBS-type repeats


    Find genes that share domains with DOHH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOHH_HUMAN, Q9BU89
    Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an
    essential post-translational modification only found in mature eIF-5A factor
    Catalytic activity: [eIF5A]-deoxyhypusine + AH(2) + O(2) = [eIF5A]-hypusine + A + H(2)O

         Enzyme Number (IUBMB): EC 1.14.99.291 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI17213197
    GO:0019135deoxyhypusine monooxygenase activity TAS--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with DOHH           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOHH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOHH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOHH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOHH

    miRNA
    Products:
        
    miRTarBase miRNAs that target DOHH:
    hsa-mir-331-3p (MIRT006887), hsa-mir-642a-5p (MIRT006888)

    Block miRNA regulation of human, mouse, rat DOHH using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DOHH:
    hsa-miR-889 hsa-miR-331-3p hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidDOHH 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat DOHH

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DOHH (NM_031304)
    Sino Biological Human cDNA Clone for DOHH
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOHH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOHH

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOHH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DOHH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOHH About    
    See pathways by source

    SuperPathContained pathways About
    1PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    Hypusine synthesis from eIF5A-lysine0.00
    hypusine biosynthesis0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30


    Find genes that share SuperPaths with DOHH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DOHH
        hypusine biosynthesis


    1 Reactome Pathway for DOHH
        Hypusine synthesis from eIF5A-lysine


    UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89
    Pathway: Protein modification; eIF5A hypusination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOHH
    Interactions:

        Search GeneGlobe Interaction Network for DOHH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DOHH (Q9BU893 ENSP000002509374) via UniProtKB, MINT, STRING, and/or I2D (see all 95)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227314O431963I2D: score=1 
    ENSG00000230293O431963I2D: score=1 
    ENSG00000230961O431963I2D: score=1 
    ENSG00000235222O431963I2D: score=1 
    MSH5O431963I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008612peptidyl-lysine modification to hypusine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with DOHH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOHH

    3 HMDB Compounds for DOHH    About this table
    CompoundSynonyms CAS #PubMed Ids
    DeoxyhypusineN(6)-(4-Aminobutyl)lysine (see all 2)82543-85-9--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DOHH gene (2 alternative transcripts): 
    NM_001145165.1  NM_031304.4  

    Unigene Cluster for DOHH:

    Deoxyhypusine hydroxylase/monooxygenase
    Hs.515064  [show with all ESTs]
    Unigene Representative Sequence: NM_001145165
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250937(uc002lxs.3) ENST00000586906 ENST00000592858 ENST00000587122
    ENST00000427575(uc010xhl.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DOHH using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DOHH:
    hsa-miR-889 hsa-miR-331-3p hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidDOHH 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DOHH
    Predesigned siRNA for gene silencing in human, mouse, rat DOHH
    Clone
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    OriGene ORF clones in mouse, rat for DOHH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DOHH (NM_031304)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOHH
    Primer
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    OriGene qPCR primer pairs and template standards for DOHH
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOHH
      QuantiTect SYBR Green Assays in human, mouse, rat DOHH
      QuantiFast Probe-based Assays in human, mouse, rat DOHH

    Additional mRNA sequence: 

    BC002817.2 BC009863.2 

    5 DOTS entries:

    DT.211662  DT.97858688  DT.100775787  DT.91760652  DT.95269652 

    Selected AceView cDNA sequences (see all 105):

    BG491509 AI937482 AW340212 AW006196 BM559040 AW135672 AI479685 AI128417 
    AW002050 BU624567 BF434395 BM558865 CF141889 BU147125 CA774553 BV184325 
    BI600415 AA262575 BE795251 BC002817 BI602861 BI549492 R69784 AI222070 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DOHH    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                          -                                 
    SP2:              -           -                                 
    SP3:                                                            


    ECgene alternative splicing isoforms for DOHH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOHH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAGCACG
    DOHH Expression
    About this image


    DOHH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Lymph (Hematopoietic System)
    DOHH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOHH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515064
        Custom PCR Arrays for DOHH
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOHH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DOHH gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dohh1 , 5 deoxyhypusine hydroxylase/monooxygenase1, 5 80.62(n)1
    85.05(a)1
      10 (39.72 cM)5
    1021151  NM_133964.21  NP_598725.21 
     813844285 
    chicken
    (Gallus gallus)
    Aves DOHH1 deoxyhypusine hydroxylase/monooxygenase 74.61(n)
    75.17(a)
      427066  NM_001031413.1  NP_001026584.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80132 Xenopus laevis transcribed sequence with moderate similarity more 74.85(n)    CA972864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb33c042 wufb33c04 73.51(n)   321732  BC046086.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nero1 nero 61.62(n)
    59.26(a)
      43740  NM_143630.1  NP_651887.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dohh-11 dohh-1 55.44(n)
    58.33(a)
      3565578  NM_063878.3  NP_496279.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LIA1(YJR070C)4
    LIA11
    Deoxyhypusine hydroxylase, a HEAT-repeat containing more4
    LIA11
    50.98(n)1
    52.21(a)1
      10(570598-569621)4
    8535341, 4  NP_012604.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G581801 AT3G58180 50.9(n)
    53.43(a)
      824987  NM_115680.2  NP_567062.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g06261001 Os12g0626100 52.35(n)
    51.99(a)
      4352843  NM_001073854.1  NP_001067322.2 


    ENSEMBL Gene Tree for DOHH (if available)
    TreeFam Gene Tree for DOHH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOHH (see all 302)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009572351,2
    C--3490321(-) GGAGGA/CAAAAC 2 -- ds50010--------
    rs1846751971,2
    --3490454(+) GAGCCA/GGCGGA 2 -- ds50010--------
    rs1898949091,2
    --3490595(+) GAGCTA/GGCTGG 2 -- ds50010--------
    rs1140917181,2
    F--3490696(+) AGCCAA/GTGGCT 2 -- ds50011Minor allele frequency- G:0.10WA 118
    rs609826351,2
    C,F--3490743(+) CTCTCG/CGGGAA 2 -- ds50013Minor allele frequency- C:0.32WA 122
    rs1158870011,2
    C,F--3490749(+) GGGAAC/TGTTCC 2 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1467597261,2
    --3490798(+) TCACCC/TAACAC 2 -- ds50010--------
    rs10518031,2
    C,F,H--3490908(+) CCCACT/CCAGGG 2 -- ut31 ese322Minor allele frequency- C:0.43EA MN NS NA WA 4026
    rs1807338861,2
    --3490939(+) CAGGCC/TTCGGG 2 -- ut310--------
    rs22864401,2
    C,F,H--3490951(+) TGGGGG/AAGTCA 2 -- ut31 ese315Minor allele frequency- A:0.12EA NS WA 3508

    HapMap Linkage Disequilibrium report for DOHH (3490819 - 3500938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DOHH:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3651n71CNV Loss21882294
    nsv910722CNV Loss21882294
    dgv3652n71CNV Loss21882294
    nsv470114CNV Loss18288195
    dgv3654n71CNV Loss21882294
    nsv910723CNV Loss21882294
    nsv526602CNV Loss19592680
    dgv3653n71CNV Loss21882294
    dgv3655n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611262    OMIM disorders: --

    1 disease for DOHH:    
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    actinomycosis

    1 disease from the University of Copenhagen DISEASES database for DOHH:
    Actinomycosis

    Find genes that share disorders with DOHH           About GenesLikeMe


    Export disorders for DOHH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOHH gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with DOHH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PubMed id 16371467)1, 2, 3 Park J.-H.... Park M.H. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    2. Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis. (PubMed id 16533814)1, 2, 3 Kim Y.S.... Park M.H. (J. Biol. Chem. 2006)
    3. Human deoxyhypusine hydroxylase, an enzyme involved in regulating cell growth, activates O(2) with a nonheme diiron center. (PubMed id 19706422)1, 2 Vu V.V....Que L. Jr. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    8. Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR-642-5p in prostate cancer cells. (PubMed id 22908221)1 Epis M.R....Leedman P.J. (J. Biol. Chem. 2012)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83475 HGNC: 28662 AceView: MGC4293 Ensembl:ENSG00000129932 euGenes: HUgn83475
    ECgene: DOHH H-InvDB: DOHH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOHH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOHH gene:
    Search GeneIP for patents involving DOHH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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