Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOHH Gene

protein-coding   GIFtS: 52
GCID: GC19M003443

Deoxyhypusine Hydroxylase/Monooxygenase

(Previous name: HEAT-like (PBS lyase) repeat containing 1)
(Previous symbol: HLRC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Deoxyhypusine Hydroxylase/Monooxygenase1 2     hDOHH2 3
HLRC11 2 3     HEAT-Like Repeat-Containing Protein 12 3
HEAT-Like (PBS Lyase) Repeat Containing 11 2     EC 1.14.99.293 8
Deoxyhypusine Dioxygenase2 3     Deoxyhypusine Hydroxylase2
Deoxyhypusine Monooxygenase2 3     

External Ids:    HGNC: 286621   Entrez Gene: 834752   Ensembl: ENSG000001299327   OMIM: 6112625   UniProtKB: Q9BU893   

Export aliases for DOHH gene to outside databases

Previous GC identifer: GC19M003256


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOHH Gene:
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino
acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine
in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript
variants.(provided by RefSeq, Feb 2009)

GeneCards Summary for DOHH Gene: 
DOHH (deoxyhypusine hydroxylase/monooxygenase) is a protein-coding gene. Diseases associated with DOHH include glioblastoma, and prostate cancer, and among its related super-pathways are Hypusine synthesis from eIF5A-lysine and Post-translational protein modification. GO annotations related to this gene include deoxyhypusine monooxygenase activity and metal ion binding.

UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89
Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an
essential post-translational modification only found in mature eIF-5A factor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOHH gene promoter:
         AhR   NRF-2   AP-2gamma   ATF6   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOHH promoter sequence
   Search SABiosciences Chromatin IP Primers for DOHH

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOHH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

DOHH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOHH gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003443:  view genomic region     (about GC identifiers)

Start:
3,490,819 bp from pter      End:
3,500,938 bp from pter
Size:
10,120 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89 (See protein sequence)
Recommended Name: Deoxyhypusine hydroxylase  
Size: 302 amino acids; 32904 Da
Cofactor: Binds 2 Fe(2+) ions per subunit
Secondary accessions: O75265

Explore the universe of human proteins at neXtProt for DOHH: NX_Q9BU89

Explore proteomics data for DOHH at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BU89

  • 4/8 DME Specific Peptides for DOHH (Q9BU89) (see all 8)
     SALLKHE  SVDPAPP  ESCEVALDM  RYRAMFALR 

    DOHH Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOHH Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001138637.1  NP_112594.1  

    ENSEMBL proteins: 
     ENSP00000250937   ENSP00000464905   ENSP00000468416   ENSP00000398882  
    Reactome Protein details: Q9BU89
    Human Recombinant Protein Products for DOHH: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for DOHH
    OriGene Protein Over-expression Lysate for DOHH
    OriGene MassSpec for DOHH 
    OriGene Custom Protein Services for DOHH
    GenScript Custom Purified and Recombinant Proteins Services for DOHH
    Novus Biologicals DOHH Protein
    Novus Biologicals DOHH Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOHH 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    DOHH for ontologies           About GeneDecksing



    DOHH Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DOHH
    GenScript Custom Superior Antibodies Services for DOHH
    Novus Biologicals DOHH Antibodies
    Abcam antibodies for DOHH
    Cloud-Clone Corp. Antibodies for DOHH 
    Search ThermoFisher Antibodies for DOHH
    LSBio Antibodies in human, mouse, rat for DOHH 

    Assay Products for DOHH: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DOHH
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DOHH
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DOHH 
    Cloud-Clone Corp. CLIAs for DOHH


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR021133 HEAT_type_2
     IPR004155 PBS_lyase_HEAT
     IPR027517 Deoxyhypusine_hydroxylase
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9BU89

    ProtoNet protein and cluster: Q9BU89

    1 Blocks protein domain: IPB004155 PBS lyase HEAT-like repeat

    UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89
    Similarity: Belongs to the deoxyhypusine hydroxylase family
    Similarity: Contains 5 HEAT-like PBS-type repeats


    DOHH for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOHH_HUMAN, Q9BU89
    Function: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an
    essential post-translational modification only found in mature eIF-5A factor
    Catalytic activity: Protein N(6)-(4-aminobutyl)-L-lysine + AH(2) + O(2) = protein
    N(6)-((R)-4-amino-2-hydroxybutyl)-L-lysine + A + H(2)O

         Enzyme Number (IUBMB): EC 1.14.99.291 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI17213197
    GO:0019135deoxyhypusine monooxygenase activity TAS--
    GO:0046872metal ion binding IEA--
         
    DOHH for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOHH 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOHH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOHH 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOHH 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOHH
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DOHH:
    hsa-miR-889 hsa-miR-331-3p hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidDOHH 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DOHH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOHH

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DOHH
    Sirion Biotech Customized adenovirus for overexpression of DOHH

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DOHH (see all 13)
    OriGene ORF clones in mouse, rat for DOHH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DOHH (NM_031304)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOHH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOHH
    Sirion Biotech Customized lentivirus for stable overexpression of DOHH 
                         Customized lentivirus expression plasmids for stable overexpression of DOHH 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DOHH
    Search LifeMap BioReagents cell lines for DOHH
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOHH


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DOHH About                                                                                                See pathways by source

    SuperPathContained pathways About
    1hypusine biosynthesis
    hypusine biosynthesis0.50
    Hypusine synthesis from eIF5A-lysine0.50
    2Asparagine N-linked glycosylation
    Post-translational protein modification0.44
    Metabolism of proteins0.35
    3PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DOHH
        hypusine biosynthesis

    4        Reactome Pathways for DOHH
        Hypusine synthesis from eIF5A-lysine
    Metabolism of proteins
    Post-translational protein modification
    PTM: gamma carboxylation, hypusine formation and arylsulfatase activation


    UniProtKB/Swiss-Prot: DOHH_HUMAN, Q9BU89
    Pathway: Protein modification; eIF5A hypusination


    DOHH for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOHH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/79 Interacting proteins for DOHH (Q9BU893 ENSP000002509374) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227314O431963I2D: score=1 
    ENSG00000230293O431963I2D: score=1 
    ENSG00000235222O431963I2D: score=1 
    MSH5O431963I2D: score=1 
    CCT2P783713, ENSP000002993004I2D: score=4 STRING: ENSP00000299300
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008612peptidyl-lysine modification to hypusine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    DOHH for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOHH

    3 HMDB Compounds for DOHH    About this table
    CompoundSynonyms CAS #PubMed Ids
    DeoxyhypusineN(6)-(4-Aminobutyl)lysine (see all 2)82543-85-9--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    Search CenterWatch for drugs/clinical trials and news about DOHH

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOHH gene (2 alternative transcripts): 
    NM_001145165.1  NM_031304.4  

    Unigene Cluster for DOHH:

    Deoxyhypusine hydroxylase/monooxygenase
    Hs.515064  [show with all ESTs]
    Unigene Representative Sequence: NM_001145165
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250937(uc002lxs.3) ENST00000586906 ENST00000592858 ENST00000587122
    ENST00000427575(uc010xhl.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOHH
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DOHH:
    hsa-miR-889 hsa-miR-331-3p hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidDOHH 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DOHH
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOHH
    Clone
    Products:
         
    OriGene clones in human, mouse for DOHH (see all 13)
    OriGene ORF clones in mouse, rat for DOHH
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DOHH (NM_031304)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOHH
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOHH
    Sirion Biotech Customized lentivirus for stable overexpression of DOHH 
                         Customized lentivirus expression plasmids for stable overexpression of DOHH 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DOHH
    OriGene qSTAR qPCR primer pairs in human, mouse for DOHH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOHH
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOHH
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOHH

    Additional mRNA sequence: 

    BC002817.2 BC009863.2 

    5 DOTS entries:

    DT.211662  DT.97858688  DT.100775787  DT.91760652  DT.95269652 

    24/105 AceView cDNA sequences (see all 105):

    CA774553 BU147125 BF434395 BU624567 BG491509 AI937482 AW006196 AW002050 
    AI128417 AW340212 BM559040 AW135672 AI479685 CF141889 BM558865 AI589665 
    BI754133 AI458431 CB852971 BQ877449 AA262575 AI370867 AI783894 BE503659 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DOHH    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                          -                                 
    SP2:              -           -                                 
    SP3:                                                            


    ECgene alternative splicing isoforms for DOHH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOHH expression in normal human tissues (normalized intensities)      DOHH embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGAGCACG
    DOHH Expression
    About this image


    DOHH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retina   
     
     Blood (Hematopoietic System)
             cd14+ cells   
     
     Brain (Nervous System)
             corpus callosum   
     
     Lymph (Hematopoietic System)

     -- (Nervous System)
             nodose nucleus   

    See DOHH Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOHH

    SOURCE GeneReport for Unigene cluster: Hs.515064
        SABiosciences Custom PCR Arrays for DOHH
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DOHH
    OriGene qSTAR qPCR primer pairs in human, mouse for DOHH
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOHH
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOHH
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOHH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOHH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DOHH gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dohh1 , 5 deoxyhypusine hydroxylase/monooxygenase1, 5 80.62(n)1
    85.05(a)1
      10 (39.72 cM)5
    1021151  NM_133964.21  NP_598725.21 
     813844285 
    chicken
    (Gallus gallus)
    Aves DOHH1 deoxyhypusine hydroxylase/monooxygenase 74.61(n)
    75.17(a)
      427066  NM_001031413.1  NP_001026584.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80132 Xenopus laevis transcribed sequence with moderate similarity more 74.85(n)    CA972864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb33c042 wufb33c04 73.51(n)   321732  BC046086.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta nero1 CG2245-PA 61.62(n)
    59.26(a)
      43740  NM_143630.1  NP_651887.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dohh-11 Protein DOHH-1 55.44(n)
    58.33(a)
      3565578  NM_063878.2  NP_496279.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LIA1(YJR070C)4
    LIA11
    Deoxyhypusine hydroxylase, a HEAT-repeat containing more4
    Lia1p1
    50.74(n)1
    52.21(a)1
      10(570598-569621)4
    8535341, 4  NP_012604.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G581801 deoxyhypusine hydroxylase 50.78(n)
    53.05(a)
      824987  NM_115680.2  NP_567062.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g06261001 hypothetical protein 52.23(n)
    51.99(a)
      4352843  NM_001073854.1  NP_001067322.2 


    ENSEMBL Gene Tree for DOHH (if available)
    TreeFam Gene Tree for DOHH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/302 SNPs in DOHH are shown (see all 302)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009572351,2
    C--3490321(-) GGAGGA/CAAAAC 2 -- ds50010--------
    rs1846751971,2
    --3490454(+) GAGCCA/GGCGGA 2 -- ds50010--------
    rs1898949091,2
    --3490595(+) GAGCTA/GGCTGG 2 -- ds50010--------
    rs1140917181,2
    F--3490696(+) AGCCAA/GTGGCT 2 -- ds50011Minor allele frequency- G:0.10WA 118
    rs609826351,2
    C,F--3490743(+) CTCTCG/CGGGAA 2 -- ds50013Minor allele frequency- C:0.32WA 122
    rs1158870011,2
    C,F--3490749(+) GGGAAC/TGTTCC 2 -- ds50011Minor allele frequency- T:0.09WA 118
    rs1467597261,2
    --3490798(+) TCACCC/TAACAC 2 -- ds50010--------
    rs10518031,2
    C,F,H--3490908(+) CCCACT/CCAGGG 2 -- ut31 ese322Minor allele frequency- C:0.43EA MN NS NA WA 4026
    rs1807338861,2
    --3490939(+) CAGGCC/TTCGGG 2 -- ut310--------
    rs22864401,2
    C,F,H--3490951(+) TGGGGG/AAGTCA 2 -- ut31 ese315Minor allele frequency- A:0.12EA NS WA 3508

    HapMap Linkage Disequilibrium report for DOHH (3490819 - 3500938 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DOHH:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3651n71CNV Loss21882294
    nsv910722CNV Loss21882294
    dgv3652n71CNV Loss21882294
    nsv470114CNV Loss18288195
    dgv3654n71CNV Loss21882294
    nsv910723CNV Loss21882294
    nsv526602CNV Loss19592680
    dgv3653n71CNV Loss21882294
    dgv3655n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DOHH
    DNA2.0 Custom Variant and Variant Library Synthesis for DOHH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611262    OMIM disorders: --

    3 diseases for DOHH:    About MalaCards
    glioblastoma    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for DOHH:
    Actinomycosis

    DOHH for disorders           About GeneDecksing


    Export disorders for DOHH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOHH gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with DOHH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis. (PubMed id 16533814)1, 2, 3 Kim Y.S.... Park M.H. (2006)
    2. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PubMed id 16371467)1, 2, 3 Park J.-H.... Park M.H. (2006)
    3. Human deoxyhypusine hydroxylase, an enzyme involved i n regulating cell growth, activates O2 with a nonheme diiron center. (PubMed id 19706422)1, 2 Vu V.V....Que L. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    6. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. Expression of eukaryotic initiation factor 5A and hypu sine forming enzymes in glioblastoma patient samples: implications for new targe ted therapies. (PubMed id 22927971)1 Preukschas M....Balabanov S. (2012)
    9. Regulation of expression of deoxyhypusine hydroxylase (DOHH), the enzyme that catalyzes the activation of eIF5A, by miR-331-3p and miR -642-5p in prostate cancer cells. (PubMed id 22908221)1 Epis M.R....Leedman P.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83475 HGNC: 28662 AceView: MGC4293 Ensembl:ENSG00000129932 euGenes: HUgn83475
    ECgene: DOHH H-InvDB: DOHH

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOHH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOHH gene:
    Search GeneIP for patents involving DOHH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DOHH  
     OriGene qPCR primer pairs and template standards for DOHH   OriGene Protein Over-expression Lysate for DOHH  
     OriGene MassSpec something-or-other for DOHH   OriGene clones in human, mouse for DOHH  
     OriGene qSTAR qPCR primer pairs in human, mouse for DOHH   OriGene Purified Protein for DOHH  
     OriGene ORF clones in mouse, rat for DOHH   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DOHH   OriGene Custom Protein Services for DOHH  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOHH
     QIAGEN SeqTarget long-range PCR primers for resequencing DOHH
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOHH
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOHH
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOHH
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOHH
     GenScript Custom Purified and Recombinant Proteins Services for DOHH GenScript cDNA clones with any tag delivered in your preferred vector for DOHH
     GenScript Custom Assay Services for DOHH GenScript Custom Superior Antibodies Services for DOHH
     GenScript Custom overexpressing Cell Line Services for DOHH CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DOHH promoter
     Search Chromatin IP Primers for DOHH
     RT2 qPCR Primer Assay in human, mouse, rat DOHH
     Search GNC Networks for DOHH
     SABiosciences Custom PCR Arrays for DOHH
     Search Tocris compounds for DOHH
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DOHH antibodies
     DOHH proteins
     DOHH lysates
     Antibodies for DOHH
     See all of Abcam's Antibodies, Kits and Proteins for DOHH
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DOHH
     Antibodies for DOHH
     ELISAs for DOHH
     CLIAs for DOHH
     Search LifeMap BioReagents cell lines for DOHH
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOHH
     SwitchGear 3'UTR luciferase reporter plasmids for DOHH
     SwitchGear Promoter luciferase reporter plasmids for DOHH
     Search ThermoFisher Antibodies for DOHH
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOHH
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DOHH
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOHH
    Customized:
     lentivirus for stable overexpression of DOHH
     lentivirus expression plasmids for stable overexpression of DOHH
     adenovirus for overexpression of DOHH
     LSBio Antibodies in human, mouse, rat for DOHH
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DOHH gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4