Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DOHH Gene

Aliases for DOHH Gene

  • Deoxyhypusine Hydroxylase/Monooxygenase 2 3
  • HEAT-Like (PBS Lyase) Repeat Containing 1 2 3
  • HEAT-Like Repeat-Containing Protein 1 3 4
  • Deoxyhypusine Monooxygenase 3 4
  • Deoxyhypusine Dioxygenase 3 4
  • EC 1.14.99.29 4 63
  • HLRC1 3 4
  • HDOHH 3 4

External Ids for DOHH Gene

Previous HGNC Symbols for DOHH Gene

  • HLRC1

Previous GeneCards Identifiers for DOHH Gene

  • GC19M003443
  • GC19M003256

Summaries for DOHH Gene

Entrez Gene Summary for DOHH Gene

  • This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]

GeneCards Summary for DOHH Gene

DOHH (Deoxyhypusine Hydroxylase/Monooxygenase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include binding and deoxyhypusine monooxygenase activity.

UniProtKB/Swiss-Prot for DOHH Gene

  • Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOHH Gene

Genomics for DOHH Gene

Regulatory Elements for DOHH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOHH Gene

Chromosome:
19
Start:
3,490,821 bp from pter
End:
3,505,918 bp from pter
Size:
15,098 bases
Orientation:
Minus strand

Genomic View for DOHH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOHH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOHH Gene

Proteins for DOHH Gene

  • Protein details for DOHH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU89-DOHH_HUMAN
    Recommended name:
    Deoxyhypusine hydroxylase
    Protein Accession:
    Q9BU89
    Secondary Accessions:
    • O75265

    Protein attributes for DOHH Gene

    Size:
    302 amino acids
    Molecular mass:
    32904 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 2 Fe(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DOHH Gene

neXtProt entry for DOHH Gene

Proteomics data for DOHH Gene at MOPED

Post-translational modifications for DOHH Gene

  • Ubiquitination at Lys 18
  • Modification sites at PhosphoSitePlus

Other Protein References for DOHH Gene

Domains & Families for DOHH Gene

Suggested Antigen Peptide Sequences for DOHH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU89

UniProtKB/Swiss-Prot:

DOHH_HUMAN :
  • Belongs to the deoxyhypusine hydroxylase family.
  • Contains 5 HEAT-like PBS-type repeats.
Family:
  • Belongs to the deoxyhypusine hydroxylase family.
Similarity:
  • Contains 5 HEAT-like PBS-type repeats.
genes like me logo Genes that share domains with DOHH: view

No data available for Gene Families for DOHH Gene

Function for DOHH Gene

Molecular function for DOHH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[eIF5A]-deoxyhypusine + AH(2) + O(2) = [eIF5A]-hypusine + A + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.

Enzyme Numbers (IUBMB) for DOHH Gene

Gene Ontology (GO) - Molecular Function for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 17213197
GO:0019135 deoxyhypusine monooxygenase activity TAS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DOHH: view
genes like me logo Genes that share phenotypes with DOHH: view

Animal Model Products

miRNA for DOHH Gene

miRTarBase miRNAs that target DOHH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOHH

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DOHH Gene

Localization for DOHH Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOHH Gene COMPARTMENTS Subcellular localization image for DOHH gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOHH: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOHH Gene

Pathways & Interactions for DOHH Gene

genes like me logo Genes that share pathways with DOHH: view

UniProtKB/Swiss-Prot Q9BU89-DOHH_HUMAN

  • Pathway: Protein modification; eIF5A hypusination.

Gene Ontology (GO) - Biological Process for DOHH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with DOHH: view

No data available for SIGNOR curated interactions for DOHH Gene

Drugs & Compounds for DOHH Gene

(3) Additional Compounds for DOHH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
deoxyhypusine
  • N(6)-(4-Aminobutyl)-L-lysine
  • N(6)-(4-Aminobutyl)lysine
82543-85-9
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DOHH: view

Transcripts for DOHH Gene

Unigene Clusters for DOHH Gene

Deoxyhypusine hydroxylase/monooxygenase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOHH

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOHH Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for DOHH Gene

GeneLoc Exon Structure for
DOHH
ECgene alternative splicing isoforms for
DOHH

Expression for DOHH Gene

mRNA expression in normal human tissues for DOHH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOHH Gene

This gene is overexpressed in Bone (25.5) and Heart (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOHH Gene



SOURCE GeneReport for Unigene cluster for DOHH Gene Hs.515064

genes like me logo Genes that share expression patterns with DOHH: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DOHH Gene

Orthologs for DOHH Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOHH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOHH 36
  • 98 (a)
OneToOne
DOHH 35
  • 98.68 (n)
  • 98.34 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia DOHH 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dohh 36
  • 85 (a)
OneToOne
Dohh 16
Dohh 35
  • 80.62 (n)
  • 85.05 (a)
oppossum
(Monodelphis domestica)
Mammalia DOHH 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOHH 36
  • 86 (a)
OneToOne
LOC485060 35
  • 88.82 (n)
  • 88.04 (a)
cow
(Bos Taurus)
Mammalia DOHH 36
  • 88 (a)
OneToOne
DOHH 35
  • 85.51 (n)
  • 88.96 (a)
rat
(Rattus norvegicus)
Mammalia Dohh 35
  • 78.18 (n)
  • 83.39 (a)
chicken
(Gallus gallus)
Aves DOHH 36
  • 75 (a)
OneToOne
DOHH 35
  • 74.61 (n)
  • 75.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8013 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7532 35
LOC100145112 35
  • 63.59 (n)
  • 69.62 (a)
zebrafish
(Danio rerio)
Actinopterygii dohh 36
  • 65 (a)
OneToOne
wufb33c04 35
dohh 35
  • 63 (n)
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11146 35
fruit fly
(Drosophila melanogaster)
Insecta nero 36
  • 58 (a)
OneToOne
nero 35
  • 61.62 (n)
  • 59.26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002129 35
  • 62.68 (n)
  • 60.07 (a)
worm
(Caenorhabditis elegans)
Secernentea dohh-1 36
  • 56 (a)
OneToOne
dohh-1 35
  • 55.44 (n)
  • 58.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LIA1 38
LIA1 36
  • 44 (a)
OneToOne
LIA1 35
  • 50.98 (n)
  • 52.21 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B14080g 35
  • 50.61 (n)
  • 51.82 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR426C 35
  • 58.12 (n)
  • 49.44 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G58180 35
  • 50.9 (n)
  • 53.43 (a)
rice
(Oryza sativa)
Liliopsida Os12g0626100 35
  • 52.35 (n)
  • 51.99 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mmd1 35
  • 47.37 (n)
  • 48.77 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05252 35
  • 56.26 (n)
  • 49.12 (a)
Species with no ortholog for DOHH:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOHH Gene

ENSEMBL:
Gene Tree for DOHH (if available)
TreeFam:
Gene Tree for DOHH (if available)

Paralogs for DOHH Gene

No data available for Paralogs for DOHH Gene

Variants for DOHH Gene

Sequence variations from dbSNP and Humsavar for DOHH Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10126 -- 3,491,370(-) GCGCA(C/T)GGTTG utr-variant-3-prime
rs1051808 -- 3,492,342(+) GCGGC(C/T)GGGAC missense, reference
rs4806940 -- 3,502,307(+) ggcct(A/G)gtggc upstream-variant-2KB, intron-variant
rs4807477 -- 3,493,333(+) GGGCC(A/G)GGCGC intron-variant, downstream-variant-500B
rs4807478 -- 3,493,603(+) GAGAC(A/T)CCGTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DOHH Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3653n71 CNV Loss 21882294
nsv526602 CNV Loss 19592680
dgv3654n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294

Variation tolerance for DOHH Gene

Gene Damage Index Score: 0.82; 17.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOHH Gene

HapMap Linkage Disequilibrium report
DOHH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOHH Gene

Disorders for DOHH Gene

Relevant External Links for DOHH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOHH
genes like me logo Genes that share disorders with DOHH: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOHH Gene

Publications for DOHH Gene

  1. Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme. (PMID: 16371467) Park J.-H. … Park M.H. (Proc. Natl. Acad. Sci. U.S.A. 2006) 2 67
  2. Deoxyhypusine hydroxylase is an Fe(II)-dependent, HEAT-repeat enzyme. Identification of amino acid residues critical for Fe(II) binding and catalysis. (PMID: 16533814) Kim Y.S. … Park M.H. (J. Biol. Chem. 2006) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. Iron chaperones PCBP1 and PCBP2 mediate the metallation of the dinuclear iron enzyme deoxyhypusine hydroxylase. (PMID: 24843120) Frey A.G. … Philpott C.C. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67

Products for DOHH Gene

Sources for DOHH Gene

Back to Top

Content