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Aliases for DOCK9 Gene

Aliases for DOCK9 Gene

  • Dedicator Of Cytokinesis 9 2 3
  • Cdc42 Guanine Nucleotide Exchange Factor Zizimin-1 3 4
  • Zizimin1 2
  • ZIZIMIN1 3
  • KIAA1058 4
  • ZIZ1 3

External Ids for DOCK9 Gene

Previous GeneCards Identifiers for DOCK9 Gene

  • GC13M097143
  • GC13M098243
  • GC13M099445
  • GC13M080039

Summaries for DOCK9 Gene

GeneCards Summary for DOCK9 Gene

DOCK9 (Dedicator Of Cytokinesis 9) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Hemostasis. GO annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK6.

UniProtKB/Swiss-Prot for DOCK9 Gene

  • Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.

Gene Wiki entry for DOCK9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK9 Gene

Genomics for DOCK9 Gene

Regulatory Elements for DOCK9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOCK9 Gene

Chromosome:
13
Start:
98,793,487 bp from pter
End:
99,088,618 bp from pter
Size:
295,132 bases
Orientation:
Minus strand

Genomic View for DOCK9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOCK9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK9 Gene

Proteins for DOCK9 Gene

  • Protein details for DOCK9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZ29-DOCK9_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 9
    Protein Accession:
    Q9BZ29
    Secondary Accessions:
    • B3KX25
    • E9PFM9
    • Q5JUD4
    • Q5JUD6
    • Q5T2Q1
    • Q5TAN8
    • Q9BZ25
    • Q9BZ26
    • Q9BZ27
    • Q9BZ28
    • Q9UPU4

    Protein attributes for DOCK9 Gene

    Size:
    2069 amino acids
    Molecular mass:
    236446 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42.
    Miscellaneous:
    • Zizim means spike in Hebrew
    SequenceCaution:
    • Sequence=BAA83010.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DOCK9 Gene

    Alternative splice isoforms for DOCK9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOCK9 Gene

Proteomics data for DOCK9 Gene at MOPED

Post-translational modifications for DOCK9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOCK9 Gene

Domains & Families for DOCK9 Gene

Gene Families for DOCK9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZ29

UniProtKB/Swiss-Prot:

DOCK9_HUMAN :
  • The DHR-2 domain is necessary and sufficient for the GEF activity
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain is necessary and sufficient for the GEF activity
  • Contains 1 DHR-1 domain.
  • Contains 1 DHR-2 domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK9: view

Function for DOCK9 Gene

Molecular function for DOCK9 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.

Gene Ontology (GO) - Molecular Function for DOCK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 18729074
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DOCK9: view
genes like me logo Genes that share phenotypes with DOCK9: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOCK9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DOCK9 Gene

Localization for DOCK9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK9 Gene

Endomembrane system. Note=Associated with membranes. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOCK9 Gene COMPARTMENTS Subcellular localization image for DOCK9 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DOCK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DOCK9: view

Pathways & Interactions for DOCK9 Gene

genes like me logo Genes that share pathways with DOCK9: view

Pathways by source for DOCK9 Gene

1 BioSystems pathway for DOCK9 Gene
1 GeneGo (Thomson Reuters) pathway for DOCK9 Gene

Gene Ontology (GO) - Biological Process for DOCK9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0008150 biological_process ND --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DOCK9: view

No data available for SIGNOR curated interactions for DOCK9 Gene

Drugs & Compounds for DOCK9 Gene

(1) Drugs for DOCK9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK9: view

Transcripts for DOCK9 Gene

Unigene Clusters for DOCK9 Gene

Dedicator of cytokinesis 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOCK9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c · 35d ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40a · 40b · 40c ^ 41a · 41b · 41c ^ 42 ^
SP1:
SP2:
SP3:
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8: - -
SP9:
SP10:
SP11: - - - - -
SP12: - - - - - -
SP13: - - - - - - -
SP14: - -
SP15:
SP16:
SP17:

ExUns: 43a · 43b · 43c ^ 44 ^ 45 ^ 46a · 46b · 46c ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b · 51c ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b ^ 55 ^ 56 ^ 57 ^ 58 ^ 59a ·
SP1:
SP2:
SP3: - - - -
SP4: - - - - - -
SP5: - - -
SP6: - -
SP7: - - - -
SP8:
SP9:
SP10: - -
SP11: - -
SP12: - -
SP13: - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DOCK9 Gene

GeneLoc Exon Structure for
DOCK9
ECgene alternative splicing isoforms for
DOCK9

Expression for DOCK9 Gene

mRNA expression in normal human tissues for DOCK9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOCK9 Gene

This gene is overexpressed in Breast (37.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOCK9 Gene



SOURCE GeneReport for Unigene cluster for DOCK9 Gene Hs.596105

mRNA Expression by UniProt/SwissProt for DOCK9 Gene

Q9BZ29-DOCK9_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle.
genes like me logo Genes that share expression patterns with DOCK9: view

Protein tissue co-expression partners for DOCK9 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DOCK9 Gene

Orthologs for DOCK9 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOCK9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOCK9 35
  • 90.15 (n)
  • 95.71 (a)
DOCK9 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOCK9 35
  • 91.33 (n)
  • 97.43 (a)
DOCK9 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dock9 35
  • 87.4 (n)
  • 94.97 (a)
Dock9 16
Dock9 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DOCK9 35
  • 99.66 (n)
  • 99.85 (a)
DOCK9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dock9 35
  • 87.14 (n)
  • 94.79 (a)
oppossum
(Monodelphis domestica)
Mammalia DOCK9 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOCK9 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOCK9 35
  • 80.86 (n)
  • 91.19 (a)
DOCK9 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOCK9 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24909 35
zebrafish
(Danio rerio)
Actinopterygii dock9b 35
  • 70.85 (n)
  • 77.45 (a)
DOCK9 (2 of 2) 36
  • 71 (a)
OneToMany
dock9b 36
  • 74 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008535 35
  • 50.32 (n)
  • 43.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42533 35
  • 50.87 (n)
  • 45.24 (a)
worm
(Caenorhabditis elegans)
Secernentea F22G12.5 35
  • 42.8 (n)
  • 31.93 (a)
Species with no ortholog for DOCK9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DOCK9 Gene

ENSEMBL:
Gene Tree for DOCK9 (if available)
TreeFam:
Gene Tree for DOCK9 (if available)

Paralogs for DOCK9 Gene

Paralogs for DOCK9 Gene

Pseudogenes.org Pseudogenes for DOCK9 Gene

genes like me logo Genes that share paralogs with DOCK9: view

Variants for DOCK9 Gene

Sequence variations from dbSNP and Humsavar for DOCK9 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_053067 -
VAR_062000 -

Structural Variations from Database of Genomic Variants (DGV) for DOCK9 Gene

Variant ID Type Subtype PubMed ID
esv270394 CNV Insertion 20981092
esv2670219 CNV Deletion 23128226
esv2108331 CNV Deletion 18987734
esv2664437 CNV Deletion 23128226
esv2747868 CNV Deletion 23290073
nsv826755 CNV Loss 20364138
esv2674237 CNV Deletion 23128226
esv2747869 CNV Deletion 23290073
esv2747870 CNV Deletion 23290073
esv2747871 CNV Deletion 23290073
esv1956817 CNV Deletion 18987734
esv3791 CNV Deletion 18987735
esv2492957 CNV Deletion 19546169
esv2747872 CNV Deletion 23290073
esv1155114 CNV Deletion 17803354
esv2658888 CNV Deletion 23128226
esv27384 CNV Loss 19812545

Variation tolerance for DOCK9 Gene

Residual Variation Intolerance Score: 1.47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.89; 74.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOCK9 Gene

HapMap Linkage Disequilibrium report
DOCK9
Human Gene Mutation Database (HGMD)
DOCK9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK9 Gene

Disorders for DOCK9 Gene

Relevant External Links for DOCK9

Genetic Association Database (GAD)
DOCK9
Human Genome Epidemiology (HuGE) Navigator
DOCK9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOCK9
genes like me logo Genes that share disorders with DOCK9: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK9 Gene

Publications for DOCK9 Gene

  1. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. (PMID: 12172552) Meller N. … Schwartz M.A. (Nat. Cell Biol. 2002) 2 23 67
  2. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E. … Parrado A. (Mol. Immunol. 2008) 23 67
  3. Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. (PMID: 18056264) Kwofie M.A. … Skowronski J. (J. Biol. Chem. 2008) 23 67
  4. Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. (PMID: 15710388) Nishikimi A. … Maruyama M. (FEBS Lett. 2005) 23 67
  5. The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain. (PMID: 15247287) Meller N. … Schwartz M.A. (J. Biol. Chem. 2004) 23 67

Products for DOCK9 Gene

Sources for DOCK9 Gene

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