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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOCK9 Gene

protein-coding   GIFtS: 64
GCID: GC13M099445

Dedicator Of Cytokinesis 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 91 2     zizimin11
Cdc42 Guanine Nucleotide Exchange Factor Zizimin-12 3     ZIZIMIN12
ZIZ12 5     Dedicator Of Cytokinesis Protein 92
KIAA10583 5     

External Ids:    HGNC: 141321   Entrez Gene: 233482   Ensembl: ENSG000000883877   OMIM: 6073255   UniProtKB: Q9BZ293   

Export aliases for DOCK9 gene to outside databases

Previous GC identifers: GC13M097143 GC13M098243 GC13M080039


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DOCK9 Gene: 
DOCK9 (dedicator of cytokinesis 9) is a protein-coding gene. Diseases associated with DOCK9 include keratoconus, and bipolar disorder, and among its related super-pathways are G-protein signaling Regulation of CDC42 activity and Platelet activation, signaling and aggregation. GO annotations related to this gene include Rho GTPase binding and phospholipid binding. An important paralog of this gene is DOCK7.

UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29
Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.
Overexpression induces filopodia formation

Gene Wiki entry for DOCK9 (Dock9) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_009952.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOCK9 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   CUTL1   Gfi-1   E2F-1   E2F   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOCK9 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOCK9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3   Ensembl cytogenetic band:  13q32.3   HGNC cytogenetic band: 13q32.3

DOCK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK9 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M099445:  view genomic region     (about GC identifiers)

Start:
99,445,741 bp from pter      End:
99,738,879 bp from pter
Size:
293,139 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 9  
Size: 2069 amino acids; 236446 Da
Subunit: Homodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42
Subcellular location: Endomembrane system (Probable). Note=Associated with membranes (Probable)
Miscellaneous: 'Zizim' means 'spike' in Hebrew
Sequence caution: Sequence=BAA83010.2; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for DOCK9:
1WG7 (3D)        2WM9 (3D)        2WMN (3D)        2WMO (3D)    
Secondary accessions: B3KX25 E9PFM9 Q5JUD4 Q5JUD6 Q5T2Q1 Q5TAN8 Q9BZ25 Q9BZ26 Q9BZ27 Q9BZ28
Q9UPU4
Alternative splicing: 5 isoforms:  Q9BZ29-1   Q9BZ29-5   Q9BZ29-3   Q9BZ29-4   Q9BZ29-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK9: NX_Q9BZ29

Explore proteomics data for DOCK9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZ29

  • DOCK9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOCK9 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001123520.1  NP_001123521.1  NP_001123522.1  NP_056111.1  

    ENSEMBL proteins: 
     ENSP00000383087   ENSP00000365643   ENSP00000388193   ENSP00000407610   ENSP00000344702  
     ENSP00000403528   ENSP00000396897   ENSP00000413781   ENSP00000341086   ENSP00000401958  
     ENSP00000406883  
    Reactome Protein details: Q9BZ29
    Human Recombinant Protein Products for DOCK9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOCK9 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--
    GO:0012505endomembrane system IEA--
    GO:0016020membrane IEA--

    DOCK9 for ontologies           About GeneDecksing



    DOCK9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DOCK9
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    Assay Products for DOCK9: 
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    Cloud-Clone Corp. ELISAs for DOCK9 
    Cloud-Clone Corp. CLIAs for DOCK9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5/8 InterPro protein domains (see all 8):
     IPR021816 DOCK_C/D_N
     IPR027007 DHR-1_domain
     IPR026791 DOCK
     IPR001849 Pleckstrin_homology
     IPR026796 DOCK_D

    Graphical View of Domain Structure for InterPro Entry Q9BZ29

    ProtoNet protein and cluster: Q9BZ29

    2 Blocks protein domains:
    IPB001849 Pleckstrin-like
    IPB010703 Dedicator of cytokinesis


    UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29
    Domain: The DHR-2 domain is necessary and sufficient for the GEF activity
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 PH domain


    DOCK9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOCK9_HUMAN, Q9BZ29
    Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.
    Overexpression induces filopodia formation

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI18729074
    GO:0005543phospholipid binding IEA--
         
    DOCK9 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DOCK9:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOCK9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOCK9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOCK9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOCK9 

    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK9 (see all 27):
    hsa-miR-1271 hsa-miR-25 hsa-miR-218 hsa-miR-374c hsa-miR-9 hsa-miR-761 hsa-miR-96 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDOCK9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DOCK9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00
    2Platelet activation, signaling and aggregation
    Hemostasis0.43
    3Regulation of CDC42 activity
    Regulation of CDC42 activity
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DOCK9
        G-protein signaling Regulation of CDC42 activity


    1 GeneGo (Thomson Reuters) Pathway for DOCK9
        G-protein signaling Regulation of CDC42 activity

    1 BioSystems Pathway for DOCK9
        Regulation of CDC42 activity

    2        Reactome Pathways for DOCK9
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    DOCK9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DOCK9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for DOCK9 (Q9BZ291, 3 ENSP000003656434) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD2Q157961, 3, ENSP000002621604EBI-2695893,EBI-1040141 I2D: score=2 STRING: ENSP00000262160
    SMAD3P840221, 3, ENSP000003329734EBI-2695893,EBI-347161 I2D: score=2 STRING: ENSP00000332973
    CDC42P609533, ENSP000003144584I2D: score=3 STRING: ENSP00000314458
    PTCH1Q136353I2D: score=3 
    NEBP209291EBI-2695893,EBI-1049657
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0007596blood coagulation TAS--
    GO:0008150biological_process ND--

    DOCK9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOCK9

    1 HMDB Compound for DOCK9    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about DOCK9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOCK9 gene (4 alternative transcripts): 
    NM_001130048.1  NM_001130049.1  NM_001130050.1  NM_015296.2  

    Unigene Cluster for DOCK9:

    Dedicator of cytokinesis 9
    Hs.596105  [show with all ESTs]
    Unigene Representative Sequence: NM_001130048
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400228 ENST00000376460(uc001vnq.2 uc001vnr.2 uc010tin.1 uc001vns.2 uc010tio.1 uc010tip.1 uc001vnw.2 uc021rlw.1 uc001vnt.2)
    ENST00000419908 ENST00000451563 ENST00000340449(uc001vnu.1) ENST00000481051
    ENST00000449796 ENST00000450257 ENST00000472874 ENST00000461998 ENST00000473165
    ENST00000427887 ENST00000479769 ENST00000339416(uc010tir.1 uc010tit.1)
    ENST00000448493(uc001vnv.1 uc010tiq.1) ENST00000442173(uc010afu.1 uc010tis.1)

    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK9 (see all 27):
    hsa-miR-1271 hsa-miR-25 hsa-miR-218 hsa-miR-374c hsa-miR-9 hsa-miR-761 hsa-miR-96 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDOCK9 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK9

    Additional mRNA sequence: 

    AB028981.2 AF085864.1 AF527605.1 AK122987.1 AK126492.1 AK127215.1 AK127508.1 AK294573.1 
    AK294705.1 AK294770.1 AK300298.1 AK300331.1 BC043506.1 BC053620.1 BC136274.1 BC146814.1 
    BC171753.1 CR749658.1 

    24/28 DOTS entries (see all 28):

    DT.91771928  DT.120772799  DT.455349  DT.100790519  DT.40300458  DT.95345044  DT.86840828  DT.101983902 
    DT.100790517  DT.40202016  DT.92432489  DT.91848959  DT.102763  DT.120772727  DT.92432490  DT.120772692 
    DT.120772807  DT.120772808  DT.99970659  DT.99984886  DT.120772653  DT.120772701  DT.86838928  DT.91886612 

    24/328 AceView cDNA sequences (see all 328):

    AW513794 AW500493 AK090793 AA165512 BM968821 BQ024801 BX477638 BM353207 
    BG015473 CK825119 AL079478 BF875976 BF992833 CB242596 BX100976 AA484945 
    AI733873 BC043506 AK122987 AA165554 BU163886 AW168032 AL707343 BF590966 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK9 (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                      -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35a · 35b · 35c · 35d ^ 36 ^ 37a · 37b ^ 38 ^ 39 ^ 40a · 40b · 40c ^ 41a · 41b · 41c ^ 42 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                      -     -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 43a · 43b · 43c ^ 44 ^ 45 ^ 46a · 46b · 46c ^ 47 ^ 48 ^ 49 ^ 50 ^ 51a · 51b · 51c ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b ^ 55 ^ 56 ^ 57 ^ 58 ^ 59a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:  -                                                           -                                   -     -                                                   
    SP4:  -     -                                                     -                                   -     -     -                                             
    SP5:                                                                                                  -     -     -                                             


    ECgene alternative splicing isoforms for DOCK9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOCK9 expression in normal human tissues (normalized intensities)      DOCK9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATATTTTC
    DOCK9 Expression
    About this image


    DOCK9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Human Intestinal Microvascular Endothelial Cells (HIMEC)   
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Oral Cavity (Muscoskeletal System)
             tongue squamous cells   
     
     Intestine
             Human Intestinal Microvascular Endothelial Cells (HIMEC)   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See DOCK9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOCK9

    SOURCE GeneReport for Unigene cluster: Hs.596105

    UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29
    Tissue specificity: Widely expressed, with highest expression in heart and placenta. Expressed at intermediate
    level in kidney, brain, lung and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DOCK9 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock91 , 5 dedicator of cytokinesis 91, 5 87.31(n)1
    95(a)1
      14 (65.28 cM)5
    1054451  NM_001081039.11  NP_001074508.11 
     1215420395 
    chicken
    (Gallus gallus)
    Aves DOCK91 dedicator of cytokinesis 9 80.92(n)
    91.22(a)
      418779  XM_416974.3  XP_416974.3 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK96
    Uncharacterized protein
    84(a)
    1 ↔ 1
    3(98570714-98672688)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.249092 Xenopus laevis transcribed sequences 84.03(n)    BJ059259.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570460772   -- 75(n)    57046077 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425331 CG42533 50.91(n)
    44.98(a)
      34030  NM_135281.3  NP_609125.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F22G12.56
    Protein F22G12.5, isoform b
    22(a)
    1 → many
    I(13162499-13182808)


    ENSEMBL Gene Tree for DOCK9 (if available)
    TreeFam Gene Tree for DOCK9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOCK9 gene
    DOCK72  DOCK112  DOCK62  DOCK102  DOCK82  
    10 SIMAP similar genes for DOCK9 using alignment to 11 protein entries:     DOCK9_HUMAN (see all proteins):
    DKFZp686N04132    DRIP2    Nbla10300    DOCK11    DOCK10    DKFZp781A1532
    DOCK10.2    DOCK7    DOCK6    DOCK8

    DOCK9 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DOCK9
    PGOHUM00000235606


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6133 SNPs in DOCK9 are shown (see all 6133)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113688441,2
    C--80055581(+) TTTTT-/GTTTTT 2 -- int1 trp30--------
    rs1496425721,2
    --99445506(+) AAATCC/TGTATC 2 -- int10--------
    rs1441976291,2
    --99445580(+) CCACAA/GTGACC 2 -- int10--------
    rs1841281821,2
    --99445602(+) AGTCCC/GGTGGT 2 -- int10--------
    rs783836681,2
    C--99445661(+) CAGACA/CCCGTG 2 -- int10--------
    rs756763231,2
    C--99445662(+) AGACCC/TCGTGT 2 -- int10--------
    rs780060801,2
    C--99445663(+) GACCCC/TGTGTG 2 -- int10--------
    rs762689501,2
    C--99445664(+) ACCCCA/GTGTGA 2 -- int10--------
    rs1465426271,2
    C--99445856(+) ATTAC-/TAAAT 
            
    TAAAG
    2 -- ut310--------
    rs1883833761,2
    --99445860(+) CTAAAG/TTAAAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DOCK9 (99445741 - 99695741 bp, first 250kb of DOCK9)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for DOCK9 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2492957CNV Deletion19546169
    esv1956817CNV Deletion18987734
    esv2747870CNV Deletion23290073
    esv2747869CNV Deletion23290073
    esv2747872CNV Deletion23290073
    esv2670219CNV Deletion23128226
    esv2664437CNV Deletion23128226
    esv2747871CNV Deletion23290073
    esv2674237CNV Deletion23128226
    esv2108331CNV Deletion18987734


    Human Gene Mutation Database (HGMD): DOCK9
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607325    OMIM disorders: --

    3 diseases for DOCK9:    About MalaCards
    keratoconus    bipolar disorder    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for DOCK9:
    Keratoconus

    DOCK9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DOCK9
    Human Genome Epidemiology (HuGE) Navigator: DOCK9 (2 documents)

    Export disorders for DOCK9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOCK9 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with DOCK9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. (PubMed id 12172552)1, 2, 3, 9 Meller N....Schwartz M.A. (2002)
    2. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. (PubMed id 19745154)1, 2 Yang J....Barford D. (2009)
    5. Sequence variation in DOCK9 and heterogeneity in bipolar disorder. (PubMed id 17728666)1, 4 Detera-Wadleigh S.D....McMahon F.J. (2007)
    6. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    10. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23348 HGNC: 14132 AceView: DOCK9 Ensembl:ENSG00000088387 euGenes: HUgn23348
    ECgene: DOCK9 H-InvDB: DOCK9

    (According to HUGE)
    About This Section
    HUGE: KIAA1058

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOCK9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOCK9 gene:
    Search GeneIP for patents involving DOCK9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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