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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DOCK9 Gene

protein-coding GIFtS: 61
GCID: GC13M099445

dedicator of cytokinesis 9

Explore 3 diseases affiliated with
DOCK9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 9¹ ²
ZIZ1¹ ² ⁵
KIAA1058¹ ³ ⁵
Cdc42 Guanine Nucleotide Exchange Factor Zizimin-1² ³
ZIZIMIN1²
Dedicator Of Cytokinesis Protein 9²

External Ids:	HGNC: 14132¹	Entrez Gene: 23348²	Ensembl: ENSG00000088387⁷	OMIM: 607325⁵	UniProtKB: Q9BZ29³

Export aliases for DOCK9 gene to outside databases

Previous GC identifers: GC13M097143 GC13M098243 GC13M080039

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29

Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.

Overexpression induces filopodia formation

Gene Wiki entry for DOCK9 (Dock9)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_009952.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DOCK9 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 CUTL1 Gfi-1 E2F-1 E2F FOXO1a FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK9 promoter sequence

Search SABiosciences Chromatin IP Primers for DOCK9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.3 Ensembl cytogenetic band: 13q32.3 HGNC cytogenetic band: 13q32.3

DOCK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK9 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M099445: view genomic region (about GC identifiers)

Start:	99,445,741 bp from pter	End:	99,738,879 bp from pter
Size:	293,139 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29 (See protein sequence)

Recommended Name: Dedicator of cytokinesis protein 9

Size: 2069 amino acids; 236446 Da

Subunit: Homodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42

Subcellular location: Endomembrane system (Probable). Note=Associated with membranes (Probable)

Miscellaneous: 'Zizim' means 'spike' in Hebrew

Sequence caution: Sequence=BAA83010.2; Type=Erroneous initiation;

4 PDB 3D structures from and Proteopedia for DOCK9:

1WG7 (3D)

2WM9 (3D)

2WMN (3D)

2WMO (3D)

Secondary accessions: B3KX25 E9PFM9 Q5JUD4 Q5JUD6 Q5T2Q1 Q5TAN8 Q9BZ25 Q9BZ26 Q9BZ27 Q9BZ28 Q9UPU4

Alternative splicing: 5 isoforms: Q9BZ29-1 Q9BZ29-5 Q9BZ29-3 Q9BZ29-4 Q9BZ29-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK9: NX_Q9BZ29

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BZ29

DOCK9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001123520.1 NP_001123521.1 NP_001123522.1 NP_056111.1

ENSEMBL proteins:

ENSP00000383087 ENSP00000365643 ENSP00000388193 ENSP00000407610 ENSP00000344702

ENSP00000403528 ENSP00000396897 ENSP00000413781 ENSP00000341086 ENSP00000401958

ENSP00000406883

Reactome Protein details: Q9BZ29
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for DOCK9
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DOCK9

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005829	cytosol	TAS	--
GO:0012505	endomembrane system	IEA	--
GO:0016020	membrane	IEA	--

DOCK9 for ontologies About GeneDecksing

DOCK9 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DOCK9
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	Novus Biologicals DOCK9 Antibodies
	Search for Antibodies for DOCK9 at Abcam
	Uscn Antibodies for DOCK9
	Search ThermoFisher Antibodies for DOCK9

Assay Products for DOCK9:

	Browse Kits and Assays available from EMD Millipore
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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DOCK9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DOCK9 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR021816 DOCK_C/D_N

IPR027007 DOCK-C2

IPR026791 DOCK

IPR001849 Pleckstrin_homology

IPR026796 DOCK_D

Graphical View of Domain Structure for InterPro Entry Q9BZ29

ProtoNet protein and cluster: Q9BZ29

2 Blocks protein families:

IPB001849 Pleckstrin-like

IPB010703 Dedicator of cytokinesis

UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29

Domain: The DHR-2 domain is necessary and sufficient for the GEF activity

Similarity: Belongs to the DOCK family

Similarity: Contains 1 DHR-1 domain

Similarity: Contains 1 DHR-2 domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29

Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.

Overexpression induces filopodia formation

miRNA Products:		OriGene 3'-UTR Clone (see all 4): DOCK9 Browse MicroRNA Expression Plasmids
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		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK9 (see all 27):
		hsa-miR-1271 hsa-miR-25 hsa-miR-218 hsa-miR-374c hsa-miR-9 hsa-miR-761 hsa-miR-96 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: DOCK9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK9 (see all 7) OriGene shRNA RFP: DOCK9 OriGene siRNA: DOCK9
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Gene Editing
Products:

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DOCK9
		Search LifeMap BioReagents cell lines for DOCK9

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK9

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	--	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005515	protein binding	IPI	18729074
GO:0005525	GTP binding	--	--
GO:0005543	phospholipid binding	IEA	--

DOCK9 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for DOCK9:

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling Regulation of RAC1 activity

G-protein signaling_Regulation of CDC42 activity

0.25

G-protein signaling Regulation of CDC42 activity

0.25

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

1.00

Regulation of CDC42 activity

Regulation of CDC42 activity

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for DOCK9

G-protein signaling Regulation of CDC42 activity

1 GeneGo (Thomson Reuters) Pathway for DOCK9

G-protein signaling Regulation of CDC42 activity

1 BioSystems Pathway for DOCK9

Regulation of CDC42 activity

2 Reactome Pathways for DOCK9

	Hemostasis
	Factors involved in megakaryocyte development and platelet production

DOCK9 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DOCK9

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/12 Interacting proteins for DOCK9 (Q9BZ29^{1, 3} ENSP00000365643⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD2	Q15796¹^,³, ENSP00000262160⁴	EBI-2695893,EBI-1040141 I2D: score=2 STRING: ENSP00000262160
SMAD3	P84022¹^,³, ENSP00000332973⁴	EBI-2695893,EBI-1965323 I2D: score=2 STRING: ENSP00000332973
CDC42	P60953³, ENSP00000314458⁴	I2D: score=3 STRING: ENSP00000314458
PTCH1	Q13635³	I2D: score=3
NEB	P20929¹	EBI-2695893,EBI-1049657

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0008150	biological_process	ND	--

DOCK9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DOCK9

1 HMDB Compound for DOCK9 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about DOCK9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DOCK9 gene (4 alternative transcripts):

NM_001130048.1 NM_001130049.1 NM_001130050.1 NM_015296.2

Unigene Cluster for DOCK9:

Dedicator of cytokinesis 9

Hs.596105 [show with all ESTs]

Unigene Representative Sequence: NM_001130048

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000400228 ENST00000376460(uc001vnq.2 uc001vnr.2 uc010tin.1 uc001vns.2 uc010tio.1 uc010tip.1 uc001vnw.2 uc021rlw.1 uc001vnt.2)

ENST00000419908 ENST00000451563 ENST00000340449(uc001vnu.1) ENST00000481051

ENST00000449796 ENST00000450257 ENST00000472874 ENST00000461998 ENST00000473165

ENST00000427887 ENST00000479769 ENST00000339416(uc010tir.1 uc010tit.1)

ENST00000448493(uc001vnv.1 uc010tiq.1) ENST00000442173(uc010afu.1 uc010tis.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): DOCK9 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK9
		8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK9 (see all 27):
		hsa-miR-1271 hsa-miR-25 hsa-miR-218 hsa-miR-374c hsa-miR-9 hsa-miR-761 hsa-miR-96 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: DOCK9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK9 (see all 7) OriGene shRNA RFP: DOCK9 OriGene siRNA: DOCK9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK9

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK9 (see all 9) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK9 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): DOCK9 (NM_001130049)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK9

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK9

Additional cDNA sequence:

AB028981.2 AF085864.1 AF527605.1 AK122987.1 AK126492.1 AK127215.1 AK127508.1 AK294573.1

AK294705.1 AK294770.1 AK300298.1 AK300331.1 BC043506.1 BC053620.1 BC136274.1 BC146814.1

BC171753.1 CR749658.1

24/28 DOTS entries (see all 28):

DT.91771928 DT.120772799 DT.455349 DT.100790519 DT.40300458 DT.95345044 DT.86840828 DT.101983902

DT.100790517 DT.40202016 DT.92432489 DT.91848959 DT.102763 DT.120772727 DT.92432490 DT.120772692

DT.120772807 DT.120772808 DT.99970659 DT.99984886 DT.120772653 DT.120772701 DT.86838928 DT.91886612

24/328 AceView cDNA sequences (see all 328):

AF339774 BU156731 BX477638 BQ024801 Z39079 BC043506 CB155804 CR600775

CD514754 BF992833 BG824727 AW389763 BM353207 AI733873 AA484945 AW500493

AA165554 AW009821 BX091481 BX100976 AI022476 AI870702 CB243706 AW513794

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK9 (see all 17) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^
SP1:																																													-
SP2:
SP3:
SP4:
SP5:

ExUns:	26	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35a	·	35b	·	35c	·	35d	^	36	^	37a	·	37b	^	38	^	39	^	40a	·	40b	·	40c	^	41a	·	41b	·	41c	^	42	^
SP1:
SP2:
SP3:
SP4:																																													-		-		-		-
SP5:

ExUns:	43a	·	43b	·	43c	^	44	^	45	^	46a	·	46b	·	46c	^	47	^	48	^	49	^	50	^	51a	·	51b	·	51c	^	52a	·	52b	^	53a	·	53b	^	54a	·	54b	^	55	^	56	^	57	^	58	^	59a	·
SP1:
SP2:
SP3:	-																				-												-		-
SP4:	-		-																		-												-		-		-
SP5:																																	-		-		-

ECgene alternative splicing isoforms for DOCK9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DOCK9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATATTTTC

About this image

DOCK9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Posterior foregut-like cells (A scalable, suspensi...)

See DOCK9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOCK9

SOURCE GeneReport for Unigene cluster: Hs.596105

UniProtKB/Swiss-Prot: DOCK9_HUMAN, Q9BZ29

Tissue specificity: Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in

kidney, brain, lung and skeletal muscle

SABiosciences Custom PCR Arrays for DOCK9

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOCK9 gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DOCK9¹	dedicator of cytokinesis 9	80.92(n) 91.22(a)		418779 XM_416974.3 XP_416974.3
lizard (Anolis carolinensis)	Reptilia	DOCK9⁶	--	84(a)	1 ↔ 1	3(98573531-98660800)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24909²	Xenopus laevis transcribed sequences	84.03(n)		BJ059259.1
zebrafish (Danio rerio)	Actinopterygii	57046077²	--	75(n)		57046077
fruit fly (Drosophila melanogaster)	Insecta	CG42533¹	CG42533	50.91(n) 44.98(a)		34030 NM_135281.3 NP_609125.3
worm (Caenorhabditis elegans)	Secernentea	F22G12.5⁶	--	22(a)	possible ortholog	I(13162488-13182797)
thale cress (Arabidopsis thaliana)	eudicotyledons	SPK1⁶	guanyl-nucleotide exchange factor / GTPase binding...	20(a)	1 → many	4(9228185-9241317)
rice (Oryza sativa)	Liliopsida	--	guanine nucleotide exchange factor, putative, expr...	23(a)	1 → many	3(12000006-12006559)

ENSEMBL Gene Tree for DOCK9 (if available)
TreeFam Gene Tree for DOCK9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DOCK9 gene

DOCK7² DOCK11² DOCK6² DOCK10² DOCK8²

10 SIMAP similar genes for DOCK9 using alignment to 11 protein entries: DOCK9_HUMAN (see all proteins):

DKFZp686N04132 DRIP2 Nbla10300 DOCK11 DOCK10 DKFZp781A1532

DOCK10.2 DOCK7 DOCK6 DOCK8

DOCK9 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DOCK9
PGOHUM00000235606

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs34096236^1,2	C,	--	80047438(+)	`AATAC-/AAAAAA`	1	--	int¹		2		NA	4
rs34971128^1,2	C,	--	80083010(+)	`TATTC-/TTCCTA`	1	--	int¹		1		NA	2
rs149642572^1,2		--	99445506(+)	`AAATCC/TGTATC`	2	--	int¹		0	--	--	--	--
rs144197629^1,2		--	99445580(+)	`CCACAA/GTGACC`	2	--	int¹		0	--	--	--	--
rs184128182^1,2		--	99445602(+)	`AGTCCC/GGTGGT`	2	--	int¹		0	--	--	--	--
rs78383668^1,2	C	--	99445661(+)	`CAGACA/CCCGTG`	2	--	int¹		0	--	--	--	--
rs75676323^1,2	C	--	99445662(+)	`AGACCC/TCGTGT`	2	--	int¹		0	--	--	--	--
rs78006080^1,2	C	--	99445663(+)	`GACCCC/TGTGTG`	2	--	int¹		0	--	--	--	--
rs76268950^1,2	C	--	99445664(+)	`ACCCCA/GTGTGA`	2	--	int¹		0	--	--	--	--
rs146542627^1,2	C,	--	99445856(+)	`ATTAC-/TAAAT TAAAG`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DOCK9 (99445741 - 99695741 bp, first 250kb of DOCK9)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DOCK9
1 CNV: 66529
2 Indels: 41353 45223
Human Gene Mutation Database (HGMD): DOCK9

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK9

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DOCK9 for disorders           About GeneDecksing

OMIM gene information: 607325    OMIM disorders: --

3 diseases for DOCK9:    About MalaCards

bipolar disorder keratoconus schizophrenia

Human Genome Epidemiology (HuGE) Navigator: DOCK9 (2 documents)

Export disorders for DOCK9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DOCK9 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with DOCK9)

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Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. (PubMed id 12172552)^{1, 2, 3, 9} Meller N....Schwartz M.A. (2002)
Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)^{1, 2, 3} Cote J.-F. and Vuori K. (2002)
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor. (PubMed id 19745154)^{1, 2} Yang J....Barford D. (2009)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)^{1, 2} Kikuno R....Ohara O. (1999)
Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. (PubMed id 18056264)^{1, 9} Kwofie M.A. and Skowronski J. (2008)
Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)¹ Guo Z....Gao Y. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23348	HGNC: 14132	AceView: DOCK9	Ensembl:ENSG00000088387	euGenes: HUgn23348
ECgene: DOCK9	H-InvDB: DOCK9

(According to HUGE)
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HUGE: KIAA1058

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DOCK9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DOCK9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DOCK9 gene:
Search GeneIP for patents involving DOCK9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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