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DOCK7 Gene

protein-coding   GIFtS: 52
GCID: GC01M062920

Dedicator Of Cytokinesis 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dedicator Of Cytokinesis 71 2
ZIR22
Dedicator Of Cytokinesis Protein 72
KIAA17713

External Ids:    HGNC: 191901   Entrez Gene: 854402   Ensembl: ENSG000001166417   UniProtKB: Q96N673   

Export aliases for DOCK7 gene to outside databases

Previous GC identifers: GC01U900915 GC01M062291 GC01M062632 GC01M062692 GC01M061032


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOCK7 Gene:
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation
and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but
not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Dec 2012)

GeneCards Summary for DOCK7 Gene:
DOCK7 (dedicator of cytokinesis 7) is a protein-coding gene. Diseases associated with DOCK7 include tuberous sclerosis, and coronary heart disease. GO annotations related to this gene include Rac GTPase binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot: DOCK7_HUMAN, Q96N67
Function: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases
by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15'
phosphorylation during axon formation and consequently for neuronal polarization

Gene Wiki entry for DOCK7 (Dock7) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for DOCK7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOCK7 promoter sequence
   Search Chromatin IP Primers for DOCK7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p32.1

DOCK7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M062920:  view genomic region     (about GC identifiers)

Start:
62,920,397 bp from pter      End:
63,153,969 bp from pter
Size:
233,573 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DOCK7_HUMAN, Q96N67 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 7  
Size: 2140 amino acids; 242561 Da
Subunit: Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3
Sequence caution: Sequence=AAH16392.2; Type=Frameshift; Positions=1337; Sequence=ABC33725.1; Type=Frameshift;
Positions=911; Sequence=BAB70933.1; Type=Erroneous initiation; Sequence=BAB71042.1; Type=Frameshift;
Positions=1792; Sequence=BAC86032.1; Type=Erroneous initiation;
Secondary accessions: Q00M63 Q2PPY7 Q45RE8 Q45RE9 Q5T1B9 Q5T1C0 Q6ZV32 Q8TB82 Q96NG6 Q9C092
Alternative splicing: 6 isoforms:  Q96N67-1   Q96N67-2   Q96N67-3   Q96N67-4   Q96N67-5   Q96N67-6   (Contains a phosphoserine at position 1429. Contains a phosphoserine at position 1421. Contains a phosphoserine at position 1425)

Explore the universe of human proteins at neXtProt for DOCK7: NX_Q96N67

Explore proteomics data for DOCK7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOCK7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001258928.1  NP_001258929.1  NP_001258930.1  NP_001258931.1  NP_212132.2  

    ENSEMBL proteins: 
     ENSP00000413583   ENSP00000340742   ENSP00000384446   ENSP00000251157  
    Reactome Protein details: Q96N67

    DOCK7 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for DOCK7

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    Cloud-Clone Corp. ELISAs for DOCK7
    Cloud-Clone Corp. CLIAs for DOCK7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR021816 DOCK_C/D_N
     IPR027007 DHR-1_domain
     IPR026791 DOCK
     IPR027357 DHR-2
     IPR010703 DOCK_C

    Graphical View of Domain Structure for InterPro Entry Q96N67

    ProtoNet protein and cluster: Q96N67

    1 Blocks protein domain: IPB010703 Dedicator of cytokinesis

    UniProtKB/Swiss-Prot: DOCK7_HUMAN, Q96N67
    Domain: The DHR-2 domain mediates GEF activity
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain


    DOCK7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOCK7_HUMAN, Q96N67
    Function: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases
    by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15'
    phosphorylation during axon formation and consequently for neuronal polarization

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005488binding ----
    GO:0048365Rac GTPase binding IDA16982419
         
    DOCK7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DOCK7:
     Increased G1 DNA content 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dock7):
     adipose tissue  behavior/neurological  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  pigmentation 
     vision/eye 

    DOCK7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOCK7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOCK7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOCK7

    miRNA
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    miRTarBase miRNAs that target DOCK7:
    hsa-mir-21-5p (MIRT006315), hsa-mir-30a-5p (MIRT005202), hsa-mir-1307-3p (MIRT035812)

    Block miRNA regulation of human, mouse, rat DOCK7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOCK7 (see all 28):
    hsa-miR-30c hsa-miR-181c hsa-miR-218-2* hsa-miR-522 hsa-miR-624* hsa-miR-30d hsa-miR-548s hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidDOCK7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DOCK7
    Predesigned siRNA for gene silencing in human, mouse, rat DOCK7

    Gene Editing
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    OriGene ORF clones in mouse, rat for DOCK7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOCK7 (NM_033407)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK7

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DOCK7 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DOCK7_HUMAN, Q96N67: Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008180colocalizes with COP9 signalosome IDA18850735
    GO:0030424axon TAS16982419
    GO:0030426growth cone TAS16982419
    GO:0043005neuron projection TAS16982419
    GO:0045178basal part of cell TAS16982419

    DOCK7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOCK7 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Translation Insulin regulation of translation
    ErbB2/ErbB3 signaling events0.31
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DOCK7
        ErbB2/ErbB3 signaling events

    1 Reactome Pathway for DOCK7
        Factors involved in megakaryocyte development and platelet production



    DOCK7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOCK7
    Interactions:

        GeneGlobe Interaction Network for DOCK7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for DOCK7 (Q96N672, 3 ENSP000003407424) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271058 I2D: score=2 
    SMN2Q166372, 3MINT-8271058 I2D: score=2 
    ANXA7P200732, 3MINT-8248274 I2D: score=2 
    BCL2L1Q078172, 3MINT-8249289 I2D: score=2 
    CDKN1AP389362, 3MINT-8251806 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IMP16982419
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0007409axonogenesis IMP16982419
    GO:0031175neuron projection development IMP16982419
    GO:0032863activation of Rac GTPase activity IDA16982419

    DOCK7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOCK7

    3 HMDB Compounds for DOCK7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DOCK7 gene (5 alternative transcripts): 
    NM_001271999.1  NM_001272000.1  NM_001272001.1  NM_001272002.1  NM_033407.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454575(uc010oov.1) ENST00000340370 ENST00000489185(uc001dar.1)
    ENST00000467758 ENST00000479983 ENST00000404627(uc009wah.1) ENST00000464312
    ENST00000251157(uc001dam.3 uc001dan.3 uc001dao.3 uc001dap.3 uc001daq.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DOCK7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOCK7 (see all 28):
    hsa-miR-30c hsa-miR-181c hsa-miR-218-2* hsa-miR-522 hsa-miR-624* hsa-miR-30d hsa-miR-548s hsa-miR-4260
    SwitchGear 3'UTR luciferase reporter plasmidDOCK7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DOCK7
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    GenScript: all cDNA clones in your preferred vector: DOCK7 (NM_033407)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK7
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOCK7
      QuantiTect SYBR Green Assays in human, mouse, rat DOCK7
      QuantiFast Probe-based Assays in human, mouse, rat DOCK7

    Selected AceView cDNA sequences (see all 155):

    AX747012 AA429436 AA704274 AI814886 BQ694862 F09299 CK823569 AK125049 
    BF515907 AA374756 AI493831 AA700792 BX101334 AI251940 BQ446783 AA933066 
    BM310731 Z45289 BF436753 AB051558 AW057724 Z40520 BX487762 BX505668 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOCK7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTATGGTTT
    DOCK7 Expression
    About this image

    DOCK7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOCK7 Protein Expression

    UniProtKB/Swiss-Prot: DOCK7_HUMAN, Q96N67
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DOCK7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock71 , 5 dedicator of cytokinesis 71, 5 89.8(n)1
    98.05(a)1
      4 (45.60 cM)5
    672991  NM_026082.41  NP_080358.31 
     989366755 
    chicken
    (Gallus gallus)
    Aves DOCK71 dedicator of cytokinesis 7 82.31(n)
    96.17(a)
      424687  XM_004936861.1  XP_004936918.1 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK76
    dedicator of cytokinesis 7
    93(a)
    1 ↔ 1
    4(99807799-99951111)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dock61 dedicator of cytokinesis 6 79.55(n)
    92.9(a)
      100127844  XM_004913936.1  XP_004913993.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dock71 dedicator of cytokinesis 7 75.71(n)
    89.78(a)
      568817  XM_005165886.1  XP_005165943.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Zir1 Zizimin-related 54.95(n)
    52.26(a)
      33165  NM_134645.3  NP_608489.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F46H5.41 F46H5.4 46.6(n)
    35.82(a)
      180988  NM_076818.3  NP_509219.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SPK11 SPK1 42.85(n)
    29.84(a)
      827328  NM_117729.7  NP_193367.7 


    ENSEMBL Gene Tree for DOCK7 (if available)
    TreeFam Gene Tree for DOCK7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOCK7 gene
    DOCK92  DOCK112  DOCK62  DOCK102  DOCK82  
    8 SIMAP similar genes for DOCK7 using alignment to 5 protein entries:     DOCK7_HUMAN (see all proteins):
    DOCK6    DOCK8    DOCK9    DOCK10    DRIP2    DKFZp686N04132
    Nbla10300    DKFZp781A1532

    DOCK7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOCK7 (see all 4453)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs717994171,2
    C--61032020(+) ATTCA-/A/AT  
            
    TGTAA
    4 -- ds50010--------
    rs113495221,2
    C--61060062(+) TTTTT-/TGAGAC 4 -- int1 trp31Minor allele frequency- T:0.00CSA 2
    rs75292691,2
    C--61060923(+) TTTTTG/TTTGGG 4 -- int1 trp32Minor allele frequency- T:0.00NA CSA 3
    rs57746061,2
    C--61080479(+) TTTTT-/TAAAGG 4 -- int10--------
    rs563422641,2
    C--61080956(+) TAATT-/AATAAG 4 -- int11Minor allele frequency- A:0.00CSA 2
    rs785289691,2
    C--61080956(+) TAATTA/TATAAG 4 -- int10--------
    rs113117031,2
    C,F--61084185(+) AAATCT/-TTTTT 4 -- int1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs743076191,2
    C--61139487(+) GCTTA-/GWWAGA 4 -- int10--------
    rs30967911,2
    C--61146583(+) CCGCTA/G/TGCAAG 4 -- int11NA 2
    rs712132751,2
    C,F--61146604(+) AAAGAA/C/GAAAAA 4 -- int13NA 6

    HapMap Linkage Disequilibrium report for DOCK7 (62920397 - 63153969 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DOCK7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2408644CNV Deletion18987734
    esv1006212CNV Deletion20482838
    esv2553332CNV Deletion19546169
    esv1250656CNV Deletion17803354
    esv5210CNV Deletion18987735
    esv2749018CNV Deletion23290073
    nsv159028CNV Loss16902084
    esv5823CNV Loss19470904
    nsv870559CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    8 diseases for DOCK7:    
    About MalaCards
    tuberous sclerosis    coronary heart disease    coronary artery disease    atherosclerosis
    neuronitis    pancreatic cancer    pancreatitis    malaria


    DOCK7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DOCK7
    Human Genome Epidemiology (HuGE) Navigator: DOCK7 (7 documents)

    Export disorders for DOCK7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOCK7 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with DOCK7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (J. Cell Sci. 2002)
    2. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1, 4 Kettunen J....Ripatti S. (Nat. Genet. 2012)
    3. Genetic variants influencing circulating lipid levels and risk of coronary artery disease. (PubMed id 20864672)1, 4 Waterworth D.M....Sandhu M.S. (Arterioscler. Thromb. Vasc. Biol. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    8. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    9. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (Nat. Genet. 2009)
    10. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. (PubMed id 18193044)1, 4 Kathiresan S....Orho-Melander M. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85440 HGNC: 19190 AceView: DOCK7 Ensembl:ENSG00000116641 euGenes: HUgn85440
    ECgene: DOCK7 H-InvDB: DOCK7

    (According to HUGE)
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    HUGE: KIAA1771

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOCK7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DOCK7 gene:
    Search GeneIP for patents involving DOCK7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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