Aliases for DOCK6 Gene
External Ids for DOCK6 Gene
Previous GeneCards Identifiers for DOCK6 Gene
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
GeneCards Summary for DOCK6 Gene
DOCK6 (Dedicator Of Cytokinesis 6) is a Protein Coding gene. Diseases associated with DOCK6 include adams-oliver syndrome 2 and adams-oliver syndrome. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Hemostasis. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK11.
UniProtKB/Swiss-Prot for DOCK6 Gene
Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).