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DOCK5 Gene

protein-coding   GIFtS: 53
GCID: GC08P025098

Dedicator Of Cytokinesis 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dedicator Of Cytokinesis 51 2
Dedicator Of Cytokinesis Protein 52

External Ids:    HGNC: 234761   Entrez Gene: 800052   Ensembl: ENSG000001474597   UniProtKB: Q9H7D03   

Export aliases for DOCK5 gene to outside databases

Previous GC identifers: GC08P025247 GC08P023646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DOCK5 Gene:
DOCK5 (dedicator of cytokinesis 5) is a protein-coding gene. Diseases associated with DOCK5 include obesity, and cervicitis. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK4.

UniProtKB/Swiss-Prot: DOCK5_HUMAN, Q9H7D0
Function: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by
exchanging bound GDP for free GTP

Gene Wiki entry for DOCK5 (Dock5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOCK5 gene promoter:
         AhR   Sox5   NF-1/L   NF-1   AML1a   Egr-1   STAT5A   Nkx2-5   HNF-3beta   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOCK5 promoter sequence
   Search Chromatin IP Primers for DOCK5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

DOCK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P025098:  view genomic region     (about GC identifiers)

Start:
25,042,238 bp from pter      End:
25,275,598 bp from pter
Size:
233,361 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DOCK5_HUMAN, Q9H7D0 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 5  
Size: 1870 amino acids; 215309 Da
Sequence caution: Sequence=BAB14962.1; Type=Erroneous initiation; Sequence=BAC86503.1; Type=Erroneous initiation;
Secondary accessions: B2RNY0 Q5XKD5 Q6AI11 Q6PJS6 Q6ZTS6
Alternative splicing: 2 isoforms:  Q9H7D0-1   Q9H7D0-2   

Explore the universe of human proteins at neXtProt for DOCK5: NX_Q9H7D0

Explore proteomics data for DOCK5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOCK5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079216.4  
    ENSEMBL proteins: 
     ENSP00000387036   ENSP00000429737   ENSP00000276440   ENSP00000414125   ENSP00000428479  
    Reactome Protein details: Q9H7D0

    DOCK5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DOCK5
    GenScript Custom Purified and Recombinant Proteins Services for DOCK5
    Novus Biologicals DOCK5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOCK5

    DOCK5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DOCK5
    Novus Biologicals DOCK5 Antibodies
    Abcam antibodies for DOCK5
    Cloud-Clone Corp. Antibodies for DOCK5
    Search ThermoFisher Antibodies for DOCK5
    Search LSBio for Antibodies for DOCK5

    DOCK5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DOCK5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DOCK5
    Cloud-Clone Corp. CLIAs for DOCK5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR027007 DHR-1_domain
     IPR026791 DOCK
     IPR001452 SH3_domain
     IPR027357 DHR-2
     IPR010703 DOCK_C

    Graphical View of Domain Structure for InterPro Entry Q9H7D0

    ProtoNet protein and cluster: Q9H7D0

    1 Blocks protein domain: IPB010703 Dedicator of cytokinesis

    UniProtKB/Swiss-Prot: DOCK5_HUMAN, Q9H7D0
    Domain: The DHR-2 domain may mediate some GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 SH3 domain


    DOCK5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOCK5_HUMAN, Q9H7D0
    Function: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by
    exchanging bound GDP for free GTP

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ISS--
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    DOCK5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DOCK5:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dock5):
     embryogenesis  mortality/aging  muscle  vision/eye 

    DOCK5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOCK5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOCK5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOCK5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOCK5

    miRNA
    Products:
        
    miRTarBase miRNAs that target DOCK5:
    hsa-mir-93-3p (MIRT038767), hsa-mir-7-5p (MIRT025783), hsa-mir-98-5p (MIRT027646), hsa-mir-877-3p (MIRT036937), hsa-mir-222-3p (MIRT046721), hsa-mir-16-5p (MIRT031712), hsa-let-7b-5p (MIRT001638), hsa-mir-21-5p (MIRT006314)

    Block miRNA regulation of human, mouse, rat DOCK5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOCK5 (see all 23):
    hsa-miR-4291 hsa-miR-607 hsa-miR-136 hsa-miR-25 hsa-miR-624* hsa-miR-488 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidDOCK5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DOCK5
    Predesigned siRNA for gene silencing in human, mouse, rat DOCK5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DOCK5

    Clone
    Products:
         
    OriGene clones in human, mouse for DOCK5 (see all 6)
    OriGene ORF clones in mouse, rat for DOCK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOCK5 (NM_024940)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DOCK5
    Browse ESI BIO Cell Lines and PureStem Progenitors for DOCK5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DOCK5_HUMAN, Q9H7D0: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--

    DOCK5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOCK5 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DOCK5
        Factors involved in megakaryocyte development and platelet production



    DOCK5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOCK5
    Interactions:

        Search GeneGlobe Interaction Network for DOCK5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DOCK5 (Q9H7D02, 3 ENSP000002764404) via UniProtKB, MINT, STRING, and/or I2D (see all 573)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT4P509912, 3, ENSP000003779584MINT-7947479 I2D: score=1 STRING: ENSP00000377958
    TCP1P179872, 3, ENSP000003173344MINT-7947479 I2D: score=1 STRING: ENSP00000317334
    CCT2P783712, 3, ENSP000002993004MINT-7947479 I2D: score=1 STRING: ENSP00000299300
    CCT3P493682, 3, ENSP000003572444MINT-7947479 I2D: score=1 STRING: ENSP00000357244
    CCT5P486432, 3, ENSP000002803264MINT-7947479 I2D: score=1 STRING: ENSP00000280326
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0043087regulation of GTPase activity ISS--

    DOCK5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOCK5

    3 HMDB Compounds for DOCK5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DOCK5 gene: 
    NM_024940.6  

    Unigene Cluster for DOCK5:

    Dedicator of cytokinesis 5
    Hs.195403  [show with all ESTs]
    Unigene Representative Sequence: NM_024940
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000410074 ENST00000481100(uc003xef.3) ENST00000276440(uc010luf.1 uc003xei.3 uc003xeg.3 uc003xej.3)
    ENST00000495236 ENST00000444569(uc003xeh.1) ENST00000478099 ENST00000487948
    ENST00000467709 ENST00000481728 ENST00000463457 ENST00000521405 ENST00000479547

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DOCK5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOCK5 (see all 23):
    hsa-miR-4291 hsa-miR-607 hsa-miR-136 hsa-miR-25 hsa-miR-624* hsa-miR-488 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidDOCK5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DOCK5
    Predesigned siRNA for gene silencing in human, mouse, rat DOCK5
    Clone
    Products:
         
    OriGene clones in human, mouse for DOCK5 (see all 6)
    OriGene ORF clones in mouse, rat for DOCK5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOCK5 (NM_024940)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DOCK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOCK5
      QuantiTect SYBR Green Assays in human, mouse, rat DOCK5
      QuantiFast Probe-based Assays in human, mouse, rat DOCK5

    Additional mRNA sequence: 

    AK022242.1 AK024687.1 AK026663.1 AK123607.1 AK126249.1 AK129574.1 AL832744.1 BC011877.2 
    BC015352.1 BC041761.2 BC057384.1 BC137175.1 BC137176.1 BX648352.1 CR627414.1 CR749353.1 
    CR933718.1 

    12 DOTS entries:

    DT.40298392  DT.208581  DT.92027127  DT.97838482  DT.40278083  DT.121468434  DT.91939865  DT.101984151 
    DT.91732558  DT.92025565  DT.92054013  DT.100688869 

    Selected AceView cDNA sequences (see all 93):

    BM674956 BQ775987 AA676620 BC011877 BF433998 BX105780 BM983657 BF447954 
    BU675420 AA085627 BE765643 AI128661 CB139656 NM_024940 AI474143 BM969940 
    BG054577 AL832744 BM979193 CD632363 AK123607 CD632355 AV651067 AK024687 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOCK5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACAGTTAGG
    DOCK5 Expression
    About this image


    DOCK5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
    DOCK5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOCK5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.195403
        Custom PCR Arrays for DOCK5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DOCK5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOCK5
    QuantiTect SYBR Green Assays in human, mouse, rat DOCK5
    QuantiFast Probe-based Assays in human, mouse, rat DOCK5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DOCK5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock51 , 5 dedicator of cytokinesis 51, 5 87.13(n)1
    94(a)1
      14 (34.66 cM)5
    688131  NM_177780.31  NP_808448.21 
     677519285 
    chicken
    (Gallus gallus)
    Aves DOCK51 dedicator of cytokinesis 5 78(n)
    86.77(a)
      419527  XM_417678.3  XP_417678.2 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK56
    dedicator of cytokinesis 5
    80(a)
    1 ↔ 1
    GL343422.1(428479-514047)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dock51 dedicator of cytokinesis 5 69.3(n)
    74.24(a)
      100488768  XM_004912550.1  XP_004912607.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dock51 dedicator of cytokinesis 5 69.3(n)
    72.58(a)
      571688  NM_001110012.1  NP_001103482.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mbc6
    myoblast city
    35(a)
    many ↔ many
    3R(19607488-19627356)
    worm
    (Caenorhabditis elegans)
    Secernentea ced-56
    Protein CED-5 (ced-5) mRNA, complete cds
    27(a)
    1 → many
    IV(10484110-10492952) WBGene00000419
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Protein of unknown function with similarity to hum...
    17(a)
    1 → many
    XII(965897-971695) YLR422W


    ENSEMBL Gene Tree for DOCK5 (if available)
    TreeFam Gene Tree for DOCK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOCK5 gene
    DOCK42  DOCK32  DOCK12  DOCK22  
    6 SIMAP similar genes for DOCK5 using alignment to 5 protein entries:     DOCK5_HUMAN (see all proteins):
    DKFZp779M164    DKFZp781J211    DOCK1    DOCK2    DOCK3    DOCK4

    DOCK5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOCK5 (see all 5236)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880421641,2
    Cuntested125267658(+) CCTGTC/TCCACC 2 V syn10--------
    rs61505121,2
    C--23799232(+) TGTCCGTGTGTGTG
    TGTGTGT
    /-
    gtgtg
    1 -- int11Minor allele frequency- -:0.50CSA 2
    rs345810231,2
    C--23800255(+) CGTGA-/CAGTGTT 1 -- int11Minor allele frequency- CA:0.00NA 2
    rs1906403181,2
    --25040302(+) GTGAAA/GGGACA 1 -- us2k10--------
    rs1824553361,2
    --25040554(+) ACCTAC/TTGGTT 1 -- us2k10--------
    rs2011578651,2
    C--25040566(+) TGGAG-/AAAAAA 1 -- us2k10--------
    rs126782751,2
    H--25040596(+) TACCCA/CCCGTG 1 -- us2k14Minor allele frequency- C:0.00NS EA 416
    rs1406588771,2
    --25040649(+) CCACCA/GAAGTT 1 -- us2k10--------
    rs119919901,2
    C,F,H--25040664(+) TGCACT/GAATTC 1 -- us2k112Minor allele frequency- G:0.07NS EA NA CSA WA 902
    rs748963531,2
    C,F--25040673(+) TCTCCA/GATGAA 1 -- us2k15Minor allele frequency- G:0.15WA CSA NA 244

    HapMap Linkage Disequilibrium report for DOCK5 (25042238 - 25275598 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DOCK5 (see all 48):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736775CNV Deletion23290073
    esv989370CNV Deletion20482838
    esv2736776CNV Deletion23290073
    esv2736771CNV Deletion23290073
    esv2665846CNV Deletion23128226
    nsv820928CNV Deletion20802225
    esv2736772CNV Deletion23290073
    esv2657736CNV Deletion23128226
    esv2736770CNV Deletion23290073
    esv2736774CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DOCK5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOCK5
    DNA2.0 Custom Variant and Variant Library Synthesis for DOCK5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for DOCK5:    
    About MalaCards
    obesity    cervicitis


    DOCK5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DOCK5

    Export disorders for DOCK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOCK5 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with DOCK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (J. Cell Sci. 2002)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    6. Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. (PubMed id 22595969)1 El-Sayed Moustafa J.S....Coin L.J. (Hum. Mol. Genet. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80005 HGNC: 23476 AceView: DOCK5 Ensembl:ENSG00000147459 euGenes: HUgn80005
    ECgene: DOCK5 H-InvDB: DOCK5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DOCK5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOCK5 gene:
    Search GeneIP for patents involving DOCK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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