Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOCK5 Gene

protein-coding   GIFtS: 53
GCID: GC08P025098

dedicator of cytokinesis 5
  Search for DOCK5
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DOCK5    

Aliases
for DOCK5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dedicator Of Cytokinesis 51 2
FLJ210341
Dedicator Of Cytokinesis Protein 52

External Ids:    HGNC: 234761   Entrez Gene: 800052   Ensembl: ENSG000001474597   UniProtKB: Q9H7D03   

Export aliases for DOCK5 gene to outside databases

Previous GC identifers: GC08P025247 GC08P023646


Summaries
for DOCK5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DOCK5_HUMAN, Q9H7D0
Function: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging
bound GDP for free GTP

Gene Wiki entry for DOCK5 (Dock5)


Genomic Views
for DOCK5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOCK5 gene promoter:
         AhR   Sox5   NF-1/L   NF-1   AML1a   Egr-1   STAT5A   Nkx2-5   HNF-3beta   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOCK5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.2   Ensembl cytogenetic band:  8p21.2   HGNC cytogenetic band: 8p21.2

DOCK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P025098:  view genomic region     (about GC identifiers)

Start:
 25,042,238 bp from pter      End:
 25,275,598 bp from pter
Size:
 233,361 bases      Orientation:
 plus strand

Proteins
for DOCK5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DOCK5_HUMAN, Q9H7D0 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 5  
Size: 1870 amino acids; 215309 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAB14962.1; Type=Erroneous initiation; Sequence=BAC86503.1; Type=Erroneous initiation;
Secondary accessions: B2RNY0 Q5XKD5 Q6AI11 Q6PJS6 Q6ZTS6
Alternative splicing: 2 isoforms:  Q9H7D0-1   Q9H7D0-2   

Explore the universe of human proteins at neXtProt for DOCK5: NX_Q9H7D0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H7D0

    • DOCK5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079216.4  
    ENSEMBL proteins: 
     ENSP00000387036   ENSP00000429737   ENSP00000276440   ENSP00000414125   ENSP00000428479  
    Reactome Protein details: Q9H7D0
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for DOCK5 
    GenScript Custom Purified and Recombinant Proteins Services for DOCK5
    Novus Biologicals DOCK5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DOCK5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--


    DOCK5 for ontologies           About GeneDecksing



    DOCK5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DOCK5 
    GenScript Custom Superior Antibodies Services for DOCK5
    Novus Biologicals DOCK5 Antibodies
    Search for Antibodies for DOCK5 at Abcam  
    Uscn Antibodies for DOCK5
    Search ThermoFisher Antibodies for DOCK5

    Assay Products for DOCK5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DOCK5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DOCK5

    Protein Domains /
    Families
    for DOCK5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DOCK5 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR027007 DOCK-C2
     IPR026791 DOCK
     IPR026799 DOCK_A
     IPR001452 SH3_domain
     IPR010703 DOCK_C

    Graphical View of Domain Structure for InterPro Entry Q9H7D0

    ProtoNet protein and cluster: Q9H7D0

    1 Blocks protein family: IPB010703 Dedicator of cytokinesis

    UniProtKB/Swiss-Prot: DOCK5_HUMAN, Q9H7D0
    Domain: The DHR-2 domain may mediate some GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 SH3 domain


    Function
    for DOCK5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DOCK5_HUMAN, Q9H7D0
    Function: Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging
    bound GDP for free GTP

    miRNA
    Products:            		miRTarBase miRNAs that target DOCK5:
    hsa-let-7b (MIRT001638)

    OriGene 3'-UTR Clone: DOCK5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK5
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK5 (see all 23):
    hsa-miR-4291 hsa-miR-607 hsa-miR-136 hsa-miR-25 hsa-miR-624* hsa-miR-488 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: DOCK5 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK5 (see all 7)
    OriGene shRNA RFP: DOCK5
    OriGene siRNA: DOCK5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DOCK5

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK5 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DOCK5 (NM_024940)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK5 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DOCK5
    Search LifeMap BioReagents cell lines for DOCK5

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK5

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ISS--
    GO:0005525GTP binding ----
    GO:0051020GTPase binding ----


    DOCK5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DOCK5:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dock5):
     embryogenesis  mortality/aging  muscle  vision/eye 

    DOCK5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DOCK5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    2Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for DOCK5
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    DOCK5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOCK5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/537 Interacting proteins for DOCK5 (Q9H7D02, 3 ENSP000002764404) via UniProtKB, MINT, STRING, and/or I2D (see all 537)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCT4P509912, 3, ENSP000003779584MINT-7947479 I2D: score=1 STRING: ENSP00000377958
    TCP1P179872, 3, ENSP000003173344MINT-7947479 I2D: score=1 STRING: ENSP00000317334
    CCT2P783712, 3, ENSP000002993004MINT-7947479 I2D: score=1 STRING: ENSP00000299300
    CCT3P493682, 3, ENSP000003572444MINT-7947479 I2D: score=1 STRING: ENSP00000357244
    CCT5P486432, 3, ENSP000002803264MINT-7947479 I2D: score=1 STRING: ENSP00000280326
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--


    DOCK5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DOCK5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOCK5

    3 HMDB Compounds for DOCK5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about DOCK5 

    Transcripts
    for DOCK5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DOCK5 gene: 
    NM_024940.6  

    Unigene Cluster for DOCK5:

    Dedicator of cytokinesis 5
    Hs.195403  [show with all ESTs]
    Unigene Representative Sequence: NM_024940
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000410074 ENST00000481100(uc003xef.3) ENST00000276440(uc010luf.1 uc003xei.3 uc003xeg.3 uc003xej.3)
    ENST00000495236 ENST00000444569(uc003xeh.1) ENST00000478099 ENST00000487948
    ENST00000467709 ENST00000522741 ENST00000481728 ENST00000463457 ENST00000521405
    ENST00000479547

    miRNA
    Products:             		 OriGene 3'-UTR Clone: DOCK5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK5
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK5 (see all 23):
    hsa-miR-4291 hsa-miR-607 hsa-miR-136 hsa-miR-25 hsa-miR-624* hsa-miR-488 hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmid: DOCK5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK5 (see all 7)
    OriGene shRNA RFP: DOCK5
    OriGene siRNA: DOCK5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK5 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK5 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DOCK5 (NM_024940)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK5 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOCK5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK5

    Additional cDNA sequence: 

    AK022242.1 AK024687.1 AK026663.1 AK123607.1 AK126249.1 AK129574.1 AL832744.1 BC011877.2 
    BC015352.1 BC041761.2 BC057384.1 BC137175.1 BC137176.1 BX648352.1 CR627414.1 CR749353.1 
    CR933718.1 

    12 DOTS entries:

    DT.40298392  DT.208581  DT.92027127  DT.97838482  DT.40278083  DT.121468434  DT.91939865  DT.101984151 
    DT.91732558  DT.92025565  DT.92054013  DT.100688869 

    24/93 AceView cDNA sequences (see all 93):

    BX105780 BF447954 BE765643 BU675420 BM674956 BQ775987 AA085627 CB139656 
    BM983657 AI474143 AA676620 NM_024940 BC011877 BF433998 BM969940 AI128661 
    BG054577 AI339387 CB957421 CD632359 AK126249 N81158 AA693718 CD632355 

    GeneLoc Exon Structure


    Expression
    for DOCK5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOCK5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACAGTTAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DOCK5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Primary Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteLumbar Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DOCK5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOCK5

    SOURCE GeneReport for Unigene cluster: Hs.195403
        SABiosciences Custom PCR Arrays for DOCK5
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOCK5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK5

    Orthologs
    for DOCK5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DOCK5 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DOCK51 dedicator of cytokinesis 5 78.18(n)
    86.98(a)    		   419527  XM_417678.2  XP_417678.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DOCK56
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343422.1(428479-514047)
    zebrafish
    (Danio rerio)    		 Actinopterygii dock51 dedicator of cytokinesis 5 68.46(n)
    71.46(a)    		   571688  NM_001110012.1  NP_001103482.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mbc6
    		 myoblast city
    		 34(a)
    		 1 → many
    		 3R(19607488-19627356)
    worm
    (Caenorhabditis elegans)    		 Secernentea ced-56
    		 CEll Death abnormality family member (ced-5)
    		 24(a)
    		 possible ortholog
    		 IV(10484090-10492932)


    ENSEMBL Gene Tree for DOCK5 (if available)
    TreeFam Gene Tree for DOCK5 (if available) 

    Paralogs
    for DOCK5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOCK5 gene
    DOCK32  DOCK42  DOCK12  DOCK22  
    6 SIMAP similar genes for DOCK5 using alignment to 5 protein entries:     DOCK5_HUMAN (see all proteins):
    DKFZp779M164    DKFZp781J211    DOCK1    DOCK2    DOCK3    DOCK4

    DOCK5 for paralogs           About GeneDecksing



    Genomic Variants
    for DOCK5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4383 NCBI SNPs in DOCK5 are shown (see all 4383)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1906403181,2
    		--25040302(+) GTGAAA/GGGACA 1 -- us2k10--------
    rs1824553361,2
    		--25040554(+) ACCTAC/TTGGTT 1 -- us2k10--------
    rs2011578651,2
    		--25040566(+) TGGAG-/AAAAAA 1 -- us2k10--------
    rs126782751,2
    		H--25040596(+) TACCCA/CCCGTG 1 -- us2k14Minor allele frequency- C:0.00NS EA 416
    rs1406588771,2
    		--25040649(+) CCACCA/GAAGTT 1 -- us2k10--------
    rs119919901,2
    		C,F,H,--25040664(+) TGCACT/GAATTC 1 -- us2k112Minor allele frequency- G:0.07NS EA NA CSA WA 902
    rs748963531,2
    		C,F,--25040673(+) TCTCCA/GATGAA 1 -- us2k15Minor allele frequency- G:0.15WA CSA NA 244
    rs119927061,2
    		C,H--25040722(+) TACTGG/TCtttt 1 -- us2k1 trp31Minor allele frequency- T:0.00NA 2
    rs285870641,2
    		C--25040723(+) ACTGTC/TTNNNN 1 -- us2k1 trp30--------
    rs1439200221,2
    		--25040763(+) GCCCTA/GTTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DOCK5 (25042238 - 25275598 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 26 variations for DOCK5
         15/19 CNVs (see all 19): 62785 100300 39523 65092 95330 22760 59464 52500 65093 3727 6598 82539 6599 95333 36807
         7 Indels: 13042 47523 95335 59593 62786 95332 95334
    Human Gene Mutation Database (HGMD): DOCK5

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK5
    DNA2.0 Custom Variant and Variant Library Synthesis for DOCK5

    Disorders / Diseases
    for DOCK5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DOCK5 for disorders           About MalaCards

    DOCK5 for disorders           About GeneDecksing


    Export disorders for DOCK5 gene to outside databases

    Publications
    for DOCK5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOCK5 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DOCK5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (2002)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Novel association approach for variable number tandem repeats (VNTRs) identifies DOCK5 as a susceptibility gene for severe obesity. (PubMed id 22595969)1 El-Sayed Moustafa J.S....Coin L.J. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)

    External Searches for DOCK5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DOCK5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80005 HGNC: 23476 AceView: DOCK5 Ensembl:ENSG00000147459 euGenes: HUgn80005
    ECgene: DOCK5 H-InvDB: DOCK5

    Other Databases showing DOCK5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DOCK5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOCK5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DOCK5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DOCK5 gene:
    Search GeneIP for patents involving DOCK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DOCK5 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DOCK5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK5  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DOCK5   OriGene 3'-UTR Clone for DOCK5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DOCK5   OriGene Custom Protein Services for DOCK5  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOCK5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK5
     GenScript Custom Purified and Recombinant Proteins Services for DOCK5 GenScript cDNA clones with any tag delivered in your preferred vector for DOCK5
     GenScript Custom Assay Services for DOCK5 GenScript Custom Superior Antibodies Services for DOCK5
     GenScript Custom overexpressing Cell Line Services for DOCK5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DOCK5 promoter
     Search Chromatin IP Primers for DOCK5
     RT2 qPCR Primer Assay in human, mouse, rat DOCK5
     Search GNC Networks for DOCK5
     SABiosciences Custom PCR Arrays for DOCK5
     Search Tocris compounds for DOCK5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DOCK5 antibodies
     DOCK5 proteins
     Search for Antibodies for DOCK5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DOCK5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DOCK5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DOCK5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK5
     SwitchGear 3'UTR luciferase reporter plasmids for DOCK5
     SwitchGear Promoter luciferase reporter plasmids for DOCK5
     Search ThermoFisher Antibodies for DOCK5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DOCK5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4