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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOCK4 Gene

protein-coding   GIFtS: 62
GCID: GC07M111366

Dedicator Of Cytokinesis 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 41 2
KIAA07163 5
Dedicator Of Cytokinesis Protein 42

External Ids:    HGNC: 191921   Entrez Gene: 97322   Ensembl: ENSG000001285127   OMIM: 6076795   UniProtKB: Q8N1I03   

Export aliases for DOCK4 gene to outside databases

Previous GC identifers: GC07M109849 GC07M110912 GC07M110926 GC07M110928 GC07M110960 GC07M111153 GC07M105734


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOCK4 Gene:
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1)
domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a
guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations
in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced
variants which encode different protein isoforms have been described, but only one has been fully characterized.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DOCK4 Gene: 
DOCK4 (dedicator of cytokinesis 4) is a protein-coding gene. Diseases associated with DOCK4 include intraductal papilloma, and colorectal cancer, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include PDZ domain binding and SH3 domain binding. An important paralog of this gene is DOCK3.

UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0
Function: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as
a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free
GTP

Gene Wiki entry for DOCK4 (Dock4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOCK4 gene promoter:
         STAT5B   Pbx1a   Olf-1   IRF-1   Egr-4   Evi-1   AREB6   Chx10   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): DOCK4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOCK4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.1

DOCK4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M111366:  view genomic region     (about GC identifiers)

Start:
111,366,164 bp from pter      End:
111,846,466 bp from pter
Size:
480,303 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 110,734,721-111,215,001     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 4  
Size: 1966 amino acids; 225206 Da
Subunit: Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG.
Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2
Subcellular location: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytosol
Miscellaneous: Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it
is not the case with the Leu-1718 variant
Sequence caution: Sequence=BAC03696.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O14584 O94824 Q8NB45
Alternative splicing: 4 isoforms:  Q8N1I0-1   Q8N1I0-2   Q8N1I0-3   Q8N1I0-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK4: NX_Q8N1I0

Explore proteomics data for DOCK4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1I0

  • DOCK4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOCK4 Protein Expression
    REFSEQ proteins: NP_055520.3  
    ENSEMBL proteins: 
     ENSP00000412834   ENSP00000410746   ENSP00000404179   ENSP00000397412   ENSP00000393486  
     ENSP00000406298   ENSP00000406468   ENSP00000403504   ENSP00000440944  
    Reactome Protein details: Q8N1I0
    Human Recombinant Protein Products for DOCK4: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOCK4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol IDA--
    GO:0012505endomembrane system IEA--
    GO:0016020membrane IDA--
    GO:0032420stereocilium ISS16464467

    DOCK4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR011511 SH3_2
     IPR027007 DHR-1_domain
     IPR026800 DOCK_B
     IPR026791 DOCK
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q8N1I0

    ProtoNet protein and cluster: Q8N1I0

    1 Blocks protein domain: IPB010703 Dedicator of cytokinesis

    UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0
    Domain: The DHR-2 domain probably mediates the GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 SH3 domain


    DOCK4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOCK4_HUMAN, Q8N1I0
    Function: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as
    a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free
    GTP

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI16464467
    GO:0017124SH3 domain binding IEA--
    GO:0030165PDZ domain binding IPI16464467
    GO:0030675Rac GTPase activator activity IDA16464467
         
    DOCK4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DOCK4:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOCK4 
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    hsa-mir-155 (MIRT005411)

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    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK4 (see all 48):
    hsa-miR-4291 hsa-miR-429 hsa-miR-106a hsa-miR-200a hsa-miR-624 hsa-miR-548l hsa-miR-141 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidDOCK4 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DOCK4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for DOCK4
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    DOCK4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOCK4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for DOCK4 (Q8N1I02, 3 ENSP000004041794) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHABP319462, 3, ENSP000003001614MINT-50987 I2D: score=2 STRING: ENSP00000300161
    HNRNPLP148663, ENSP000002214194I2D: score=2 STRING: ENSP00000221419
    FASLGP480233, ENSP000003566944I2D: score=1 STRING: ENSP00000356694
    APCP250543I2D: score=1 
    DNM2ENSP000003527214STRING: ENSP00000352721
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0032855positive regulation of Rac GTPase activity IDA16464467
    GO:0060326cell chemotaxis IMP--

    DOCK4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOCK4

    3 HMDB Compounds for DOCK4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about DOCK4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOCK4 gene: 
    NM_014705.3  

    Unigene Cluster for DOCK4:

    Dedicator of cytokinesis 4
    Hs.654652  [show with all ESTs]
    Unigene Representative Sequence: NM_014705
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423057(uc011kml.2 uc011kmm.2 uc003vfw.3) ENST00000428084(uc003vfx.3 uc003vfy.3 uc010ljt.1)
    ENST00000486186(uc003vfv.3) ENST00000437633 ENST00000445943 ENST00000494769
    ENST00000428053 ENST00000437129 ENST00000450156 ENST00000492436 ENST00000417165
    ENST00000464338 ENST00000469898 ENST00000476846(uc003vga.1) ENST00000492532
    ENST00000468571 ENST00000494651
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidDOCK4 3' UTR sequence
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    Additional mRNA sequence: 

    AB018259.2 AK091557.1 AK098050.1 AK294722.1 AK294820.1 AK309605.1 AY233380.1 BC111430.1 
    BC117688.2 BC117689.1 BC117694.1 

    8 DOTS entries:

    DT.95265645  DT.442189  DT.100813652  DT.121108727  DT.121108747  DT.99933716  DT.95265646  DT.101973415 

    24/94 AceView cDNA sequences (see all 94):

    AA149885 AK091557 Z44118 CK906300 AK098050 AA308532 AI359664 AW148941 
    AA232140 CR622980 BQ029063 BU152969 BU178299 AW015993 AL119647 AX747059 
    NM_014705 AY233380 BQ022632 F09048 BM717835 AI431876 AA668695 AK095906 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK4    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b ^ 48 ^ 49 ^ 50 ^
    SP1:                                      -                                                                                         -                           
    SP2:                                                                                                                                -                       -   
    SP3:                                                                                                                                                            

    ExUns: 51 ^ 52a · 52b · 52c
    SP1:                        
    SP2:                        
    SP3:                        


    ECgene alternative splicing isoforms for DOCK4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOCK4 expression in normal human tissues (normalized intensities)      DOCK4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTTGCTG
    DOCK4 Expression
    About this image


    DOCK4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Amygdala
             Caudate nucleus   
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood

    See DOCK4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOCK4

    SOURCE GeneReport for Unigene cluster: Hs.654652

    UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0
    Tissue specificity: Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary

        SABiosciences Expression via Pathway-Focused PCR Array including DOCK4: 
              Adherens Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DOCK4 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock41 , 5 dedicator of cytokinesis 41, 5 90.62(n)1
    98.32(a)1
      12 (18.06 cM)5
    2381301  NM_172803.21  NP_766391.21 
     404460535 
    chicken
    (Gallus gallus)
    Aves DOCK41 dedicator of cytokinesis 4 83.39(n)
    93.61(a)
      417779  XM_416024.3  XP_416024.3 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK46
    Uncharacterized protein
    88(a)
    1 ↔ 1
    5(58054236-58243765)
    zebrafish
    (Danio rerio)
    Actinopterygii dock4b1 dedicator of cytokinesis 4b 72.05(n)
    80.02(a)
      654774  NM_001166228.1  NP_001159700.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spg6
    sponge
    33(a)
    1 → many
    3R(24670992-24695340)
    worm
    (Caenorhabditis elegans)
    Secernentea ced-56
    Protein CED-5
    21(a)
    1 → many
    IV(10484110-10492952)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YLR422W6
    Protein of unknown function with similarity to hum...
    13(a)
    1 → many
    XII(965897-971695)


    ENSEMBL Gene Tree for DOCK4 (if available)
    TreeFam Gene Tree for DOCK4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOCK4 gene
    DOCK32  DOCK12  DOCK22  DOCK52  
    6 SIMAP similar genes for DOCK4 using alignment to 13 protein entries:     DOCK4_HUMAN (see all proteins):
    DOCK3    DKFZp779M164    DOCK2    DKFZp781J211    DOCK1    DOCK5

    DOCK4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9258 SNPs in DOCK4 are shown (see all 9258)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0158264
    Ovarian cancer cell lines4--see VAR_0158262 P L mis40--------
    VAR_0158254
    A CNS cancer cell line4--see VAR_0158252 K T mis40--------
    VAR_0158234
    A CNS cancer cell line4--see VAR_0158232 T I mis40--------
    VAR_0158284
    Colorectal cancer cell line4--see VAR_0158282 S P mis40--------
    VAR_0158294
    A prostate cancer cell line4--see VAR_0158292 V M mis40--------
    VAR_0158244
    ----see VAR_0158242 E Q mis40--------
    rs1508252391,2
    C--106103270(+) TTAAGA/-GAAAG 1 -- int13Minor allele frequency- -:0.17NA 6
    rs20672281,2
    C--106103619(+) ATAAT-/AAGGTCTT 1 -- cds16Minor allele frequency- AAG:0.29EU NA EA MN 432
    rs679350221,2
    C--106103620(+) TAATG-/AAGTCTTT 1 -- cds10--------
    rs106963521,2
    C--106106594(+) TTAACTT/-AGGCT 1 -- int11Minor allele frequency- -:0.50NA 2

    HapMap Linkage Disequilibrium report for DOCK4 (111366164 - 111616164 bp, first 250kb of DOCK4)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for DOCK4 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662534CNV Deletion23128226
    esv2735037CNV Deletion23290073
    esv2670440CNV Deletion23128226
    esv2735038CNV Deletion23290073
    esv2735036CNV Deletion23290073
    esv2735039CNV Deletion23290073
    esv2621161CNV Deletion19546169
    esv2422365CNV Duplication17116639
    nsv516034CNV Loss19592680
    esv9335CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607679    OMIM disorders: --

    9 diseases for DOCK4:    About MalaCards
    intraductal papilloma    colorectal cancer    dyslexia    prostatitis
    papilloma    osteosarcoma    schizophrenia    alzheimer's disease
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for DOCK4:
    Dyslexia

    DOCK4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DOCK4
    Human Genome Epidemiology (HuGE) Navigator: DOCK4 (4 documents)

    Export disorders for DOCK4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOCK4 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with DOCK4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DOCK4, a GTPase activator, is disrupted during tumorigenesis. (PubMed id 12628187)1, 2, 3 Yajnik V....Haber D.A. (2003)
    2. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Characterization of a family with rare deletions in C NTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. (PubMed id 20346443)1, 4 Pagnamenta A.T....Monaco A.P. (2010)
    5. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    6. Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas. (PubMed id 19383911)1, 4 Kuo K.T....Wang T.L. (2009)
    7. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PubMed id 19401682)1, 4 Maestrini E....Monaco A.P. (2009)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    10. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9732 HGNC: 19192 AceView: DOCK4 Ensembl:ENSG00000128512 euGenes: HUgn9732
    ECgene: DOCK4 H-InvDB: DOCK4

    (According to HUGE)
    About This Section
    HUGE: KIAA0716

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOCK4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOCK4 gene:
    Search GeneIP for patents involving DOCK4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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