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Aliases for DOCK4 Gene

Aliases for DOCK4 Gene

  • Dedicator Of Cytokinesis 4 2 3
  • KIAA0716 4 6

External Ids for DOCK4 Gene

Previous GeneCards Identifiers for DOCK4 Gene

  • GC07M109849
  • GC07M110912
  • GC07M110926
  • GC07M110928
  • GC07M110960
  • GC07M111153
  • GC07M111366
  • GC07M105734

Summaries for DOCK4 Gene

Entrez Gene Summary for DOCK4 Gene

  • This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DOCK4 Gene

DOCK4 (Dedicator Of Cytokinesis 4) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Hemostasis. GO annotations related to this gene include SH3 domain binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK5.

UniProtKB/Swiss-Prot for DOCK4 Gene

  • Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.

Gene Wiki entry for DOCK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK4 Gene

Genomics for DOCK4 Gene

Regulatory Elements for DOCK4 Gene

Genomic Location for DOCK4 Gene

111,726,108 bp from pter
112,206,411 bp from pter
480,304 bases
Minus strand

Genomic View for DOCK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOCK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK4 Gene

Proteins for DOCK4 Gene

  • Protein details for DOCK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dedicator of cytokinesis protein 4
    Protein Accession:
    Secondary Accessions:
    • O14584
    • O94824
    • Q8NB45

    Protein attributes for DOCK4 Gene

    1966 amino acids
    Molecular mass:
    225206 Da
    Quaternary structure:
    • Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2.
    • Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant
    • Sequence=BAC03696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DOCK4 Gene


neXtProt entry for DOCK4 Gene

Proteomics data for DOCK4 Gene at MOPED

Post-translational modifications for DOCK4 Gene

  • Ubiquitination at Lys101
  • Modification sites at PhosphoSitePlus

Other Protein References for DOCK4 Gene

No data available for DME Specific Peptides for DOCK4 Gene

Domains for DOCK4 Gene

Protein Domains for DOCK4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N1I0
  • The DHR-2 domain probably mediates the GEF activity.
  • Contains 1 DHR-1 domain.
  • Contains 1 DHR-2 domain.
  • Contains 1 SH3 domain.
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK4: view

No data available for Gene Families for DOCK4 Gene

Function for DOCK4 Gene

Molecular function for DOCK4 Gene

UniProtKB/Swiss-Prot Function: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.

Gene Ontology (GO) - Molecular Function for DOCK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IDA 16464467
GO:0005515 protein binding IPI 16464467
GO:0017124 SH3 domain binding IEA --
GO:0030165 PDZ domain binding IPI 16464467
genes like me logo Genes that share ontologies with DOCK4: view

Phenotypes for DOCK4 Gene

GenomeRNAi human phenotypes for DOCK4:
genes like me logo Genes that share phenotypes with DOCK4: view

miRNA for DOCK4 Gene

miRTarBase miRNAs that target DOCK4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DOCK4 Gene

Localization for DOCK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK4 Gene

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for DOCK4 Gene COMPARTMENTS Subcellular localization image for DOCK4 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DOCK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol IDA 20679435
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IDA 20679435
GO:0032420 stereocilium ISS 16464467
genes like me logo Genes that share ontologies with DOCK4: view

Pathways for DOCK4 Gene

genes like me logo Genes that share pathways with DOCK4: view

Pathways by source for DOCK4 Gene

1 KEGG pathway for DOCK4 Gene

Gene Ontology (GO) - Biological Process for DOCK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0060326 cell chemotaxis IMP 20679435
genes like me logo Genes that share ontologies with DOCK4: view

Compounds for DOCK4 Gene

(3) HMDB Compounds for DOCK4 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with DOCK4: view

Transcripts for DOCK4 Gene

Unigene Clusters for DOCK4 Gene

Dedicator of cytokinesis 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b ^ 48 ^ 49 ^ 50 ^
SP1: - -
SP2: - -

ExUns: 51 ^ 52a · 52b · 52c

Relevant External Links for DOCK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOCK4 Gene

mRNA expression in normal human tissues for DOCK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOCK4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOCK4 Gene

SOURCE GeneReport for Unigene cluster for DOCK4 Gene Hs.654652

mRNA Expression by UniProt/SwissProt for DOCK4 Gene

Tissue specificity: Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.
genes like me logo Genes that share expressions with DOCK4: view

Orthologs for DOCK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOCK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DOCK4 35
  • 99.71 (n)
  • 99.95 (a)
DOCK4 36
  • 100 (a)
(Bos Taurus)
Mammalia DOCK4 35
  • 93 (n)
  • 98.47 (a)
DOCK4 36
  • 98 (a)
(Canis familiaris)
Mammalia DOCK4 35
  • 92.12 (n)
  • 97.34 (a)
DOCK4 36
  • 97 (a)
(Mus musculus)
Mammalia Dock4 35
  • 90.25 (n)
  • 97.81 (a)
Dock4 16
Dock4 36
  • 98 (a)
(Monodelphis domestica)
Mammalia DOCK4 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
-- 36
  • 89 (a)
-- 36
  • 99 (a)
-- 36
  • 97 (a)
-- 36
  • 91 (a)
(Gallus gallus)
Aves DOCK4 35
  • 83 (n)
  • 93.1 (a)
DOCK4 36
  • 91 (a)
(Anolis carolinensis)
Reptilia DOCK4 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dock4 35
  • 78.83 (n)
  • 88.47 (a)
(Danio rerio)
Actinopterygii DOCK4 (2 of 2) 36
  • 73 (a)
dock4b 35
  • 72.54 (n)
  • 80.64 (a)
dock4b 36
  • 78 (a)
fruit fly
(Drosophila melanogaster)
Insecta spg 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea ced-5 36
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 16 (a)
Species with no ortholog for DOCK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOCK4 Gene

Gene Tree for DOCK4 (if available)
Gene Tree for DOCK4 (if available)

Paralogs for DOCK4 Gene

Paralogs for DOCK4 Gene

genes like me logo Genes that share paralogs with DOCK4: view

Variants for DOCK4 Gene

Sequence variations from dbSNP and Humsavar for DOCK4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs453 -- 112,110,551(+) TCAGG(C/T)CACAT intron-variant
rs454 -- 112,110,579(+) CAGGG(C/T)AAAGG intron-variant
rs455 -- 112,110,793(+) ACTGC(C/T)TGGGG intron-variant
rs458 -- 112,014,577(+) TTCTA(C/T)ACCTC intron-variant
rs26846 -- 112,109,776(+) gtctc(A/G)ctctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK4 Gene

Variant ID Type Subtype PubMed ID
nsv5901 CNV Loss 18451855
esv2735036 CNV Deletion 23290073
esv2621161 CNV Deletion 19546169
esv2670440 CNV Deletion 23128226
esv2735037 CNV Deletion 23290073
esv2422365 CNV Duplication 17116639
nsv464689 CNV Gain 19166990
nsv889054 CNV Loss 21882294
esv2662534 CNV Deletion 23128226
esv2735038 CNV Deletion 23290073
esv9335 CNV Loss 19470904
esv2735039 CNV Deletion 23290073
nsv516034 CNV Loss 19592680
nsv824270 CNV Loss 20364138

Relevant External Links for DOCK4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK4 Gene

Disorders for DOCK4 Gene

(1) University of Copenhagen DISEASES for DOCK4 Gene

Relevant External Links for DOCK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DOCK4: view

No data available for UniProtKB/Swiss-Prot for DOCK4 Gene

Publications for DOCK4 Gene

  1. DOCK4, a GTPase activator, is disrupted during tumorigenesis. (PMID: 12628187) Yajnik V. … Haber D.A. (Cell 2003) 2 3 4
  2. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3 4
  3. Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas. (PMID: 19383911) Kuo K.T. … Wang T.L. (Cancer Res. 2009) 3 48
  4. High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. (PMID: 19401682) Maestrini E. … Monaco A.P. (Mol. Psychiatry 2010) 3 48
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for DOCK4 Gene

Sources for DOCK4 Gene

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