DOCK4 Gene
protein-coding GIFtS: 59
GCID: GC07M111366
|
|
dedicator of cytokinesis 4
| |
Aliases
for DOCK4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dedicator Of Cytokinesis 41 2 | | KIAA07161 3 5 | | FLJ342381 | | Dedicator Of Cytokinesis Protein 42 |
Export aliases for DOCK4 gene to outside databasesPrevious GC identifers: GC07M109849 GC07M110912 GC07M110926 GC07M110928 GC07M110960 GC07M111153 GC07M105734 |
Summaries
for DOCK4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DOCK4:
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain,a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guaninenucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this genehave been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants whichencode different protein isoforms have been described, but only one has been fully characterized. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0Function: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as aguanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP
Gene Wiki entry for DOCK4 (Dock4)
|
Genomic Views
for DOCK4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DOCK4 gene promoter:
STAT5B Pbx1a Olf-1 IRF-1 Egr-4 Evi-1 AREB6 Chx10 TGIF Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DOCK4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.1 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31.1DOCK4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M111366: view genomic region
(about GC identifiers)
Start:
|
111,366,164 bp from pter |
End:
|
111,846,466 bp from pter |
Size:
|
480,303 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 110,734,721-111,215,001 |
|
Proteins
for DOCK4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0 (See
protein sequence)Recommended Name: Dedicator of cytokinesis protein 4 Size: 1966 amino acids; 225206 Da
Subunit: Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interactswith ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2
Subcellular location: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytosol
Miscellaneous: Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it isnot the case with the Leu-1718 variant
Sequence caution: Sequence=BAC03696.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: O14584 O94824 Q8NB45Alternative splicing: 4 isoforms: Q8N1I0-1 Q8N1I0-2 Q8N1I0-3 Q8N1I0-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DOCK4: NX_Q8N1I0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N1I0
DOCK4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055520.3
ENSEMBL proteins: ENSP00000412834 ENSP00000410746 ENSP00000404179 ENSP00000397412 ENSP00000393486 ENSP00000406298 ENSP00000406468 ENSP00000403504 ENSP00000440944 Reactome Protein details: Q8N1I0
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
DOCK4 for ontologies About GeneDecksing
DOCK4 Antibody Products:
Assay Products for DOCK4: |
Protein
Domains /
Families
for DOCK4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DOCK4 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8N1I0ProtoNet protein and cluster: Q8N1I0 1 Blocks protein family: IPB010703 Dedicator of cytokinesis
UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0Domain: The DHR-2 domain probably mediates the GEF activity (By similarity)Similarity: Belongs to the DOCK familySimilarity: Contains 1 DHR-1 domainSimilarity: Contains 1 DHR-2 domainSimilarity: Contains 1 SH3 domain |
Function
for DOCK4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0Function: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as aguanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DOCK4 (NM_014705) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOCK4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK4 |
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
DOCK4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DOCK4:
|
Pathways & Interactions
for DOCK4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Factors involved in megakaryocyte development and platelet production | | | 2 | Platelet activation, signaling and aggregation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Reactome Pathways for DOCK4
DOCK4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOCK4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/9 Interacting proteins for DOCK4 (Q8N1I02, 3 ENSP000004041794) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0032855 | positive regulation of Rac GTPase activity |
IDA | 16464467 | | GO:0060326 | cell chemotaxis |
IMP | -- |
DOCK4 for ontologies About GeneDecksing
|
Drugs & Compounds
for DOCK4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DOCK4
3 HMDB Compounds for DOCK4 About this table
Search CenterWatch for drugs/clinical trials and news about DOCK4
|
Transcripts
for DOCK4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DOCK4 gene: NM_014705.3 Unigene Cluster for DOCK4: Dedicator of cytokinesis 4 Hs.654652 [show with all ESTs]Unigene Representative Sequence: NM_01470517 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000423057(uc011kml.2 uc011kmm.2 uc003vfw.3) ENST00000428084(uc003vfx.3 uc003vfy.3 uc010ljt.1)
ENST00000486186(uc003vfv.3) ENST00000437633 ENST00000445943 ENST00000494769
ENST00000428053 ENST00000437129 ENST00000450156 ENST00000492436 ENST00000417165
ENST00000464338 ENST00000469898 ENST00000476846(uc003vga.1) ENST00000492532
ENST00000468571 ENST00000494651
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DOCK4 (NM_014705) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DOCK4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK4 |
Additional cDNA sequence: AB018259.2 AK091557.1 AK098050.1 AK294722.1 AK294820.1 AK309605.1 AY233380.1 BC111430.1 BC117688.2 BC117689.1 BC117694.1 8 DOTS entries: DT.95265645 DT.442189 DT.100813652 DT.121108727 DT.121108747 DT.99933716 DT.95265646 DT.101973415 24/94 AceView cDNA sequences (see all 94): AW015993 AK091557 CK906300 AA149885 Z44118 AK098050 AA308532 AI359664 AW148941 CR622980 AA232140 BQ029063 AB018259 AX747059 NM_014705 AY233380 BU152969 AL119647 BU178299 AI431876 AK095906 AA668695 BM126591 F09048
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 | ^ | 44 | ^ | 45 | ^ | 46 | ^ | 47a | · | 47b | ^ | 48 | ^ | 49 | ^ | 50 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 51 | ^ | 52a | · | 52b | · | 52c |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | |
ECgene alternative splicing isoforms for DOCK4
|
Expression
for DOCK4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DOCK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTTGCTG
About this image
See DOCK4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOCK4
SOURCE GeneReport for Unigene cluster: Hs.654652
UniProtKB/Swiss-Prot: DOCK4_HUMAN, Q8N1I0Tissue specificity: Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary
SABiosciences Expression via Pathway-Focused PCR Array including DOCK4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOCK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK4 |
Orthologs
for DOCK4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DOCK4 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DOCK41 |
dedicator of cytokinesis 4 |
83.39(n)
93.61(a) |
|
417779 XM_416024.3 XP_416024.3 |
lizard
(Anolis carolinensis) |
Reptilia |
DOCK46 |
-- |
88(a) |
1 ↔ 1 |
5(58054236-58243765) |
zebrafish
(Danio rerio) |
Actinopterygii |
dock4b1 |
dedicator of cytokinesis 4b |
72.05(n)
80.02(a) |
|
654774 NM_001166228.1 NP_001159700.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
spg6 |
sponge |
34(a) |
1 → many |
3R(24670992-24695340) |
worm
(Caenorhabditis elegans) |
Secernentea |
ced-56 |
CEll Death abnormality family member (ced-5) |
21(a) |
possible ortholog |
IV(10484090-10492932) |
ENSEMBL Gene Tree for DOCK4 (if available)
TreeFam Gene Tree for DOCK4 (if available) |
Paralogs
for DOCK4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DOCK4 gene
- DOCK32 DOCK12 DOCK22 DOCK52
6 SIMAP similar genes for DOCK4 using alignment to 13 protein entries: DOCK4_HUMAN (see all proteins):DOCK3 DKFZp779M164 DOCK2 DKFZp781J211 DOCK1 DOCK5
DOCK4 for paralogs About GeneDecksing
|
Genomic Variants
for DOCK4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DOCK4 (111366164 - 111616164 bp, first 250kb of DOCK4)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for DOCK4
4 CNVs: 62715 52060 5246 100078 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK4 |
|
Disorders
/ Diseases
for DOCK4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DOCK4 for disorders About GeneDecksing
OMIM gene information: 607679
OMIM disorders: --
6  diseases for DOCK4: About MalaCardsprostatitis colorectal cancer dyslexia osteosarcoma
carcinoma schizophrenia
2 diseases from the University of Copenhagen DISEASES database for DOCK4:Dyslexia Intraductal papilloma Human Genome Epidemiology (HuGE) Navigator: DOCK4 (4 documents)
Export disorders for DOCK4 gene to outside databases
|
Publications
for DOCK4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DOCK4 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with DOCK4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DOCK4, a GTPase activator, is disrupted during tumorigenesis. (PubMed id 12628187)1, 2, 3 Yajnik V....Haber D.A. (2003)
- Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (2002)
- Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (1998)
- Genetic associations with C-reactive protein level and white blood cell count in the KARE study. (PubMed id 22788528)1 Kong M. and Lee C. (2013)
- Effects of partner proteins on BCA2 RING ligase activi ty. (PubMed id 22315970)1 Bacopulos S....Seth A.K. (2012)
- Genetic variants associated with breast size also infl uence breast cancer risk. (PubMed id 22747683)1 Eriksson N....Tung J.Y. (2012)
- Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. (PubMed id 22881374)1 Cummings A.C....Haines J.L. (2012)
|
External Searches for DOCK4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DOCK4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DOCK4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing DOCK4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DOCK4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DOCK4 gene:
Search GeneIP for patents involving DOCK4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DOCK4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DOCK4 | | OriGene 3'-UTR Clone for DOCK4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DOCK4 | | OriGene Custom Protein Services for DOCK4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOCK4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DOCK4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DOCK4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK4 |
|  |  |  | | | | Search ThermoFisher Antibodies for DOCK4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK4 |
|
|
|
|
