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Aliases for DOCK4 Gene

Aliases for DOCK4 Gene

  • Dedicator Of Cytokinesis 4 2 3 5
  • KIAA0716 4

External Ids for DOCK4 Gene

Previous GeneCards Identifiers for DOCK4 Gene

  • GC07M109849
  • GC07M110912
  • GC07M110926
  • GC07M110928
  • GC07M110960
  • GC07M111153
  • GC07M111366
  • GC07M105734

Summaries for DOCK4 Gene

Entrez Gene Summary for DOCK4 Gene

  • This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for DOCK4 Gene

DOCK4 (Dedicator Of Cytokinesis 4) is a Protein Coding gene. Diseases associated with DOCK4 include Dyslexia and Reading Disorder. Among its related pathways are Ras signaling pathway and Platelet activation, signaling and aggregation. GO annotations related to this gene include GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK5.

UniProtKB/Swiss-Prot for DOCK4 Gene

  • Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.

Gene Wiki entry for DOCK4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK4 Gene

Genomics for DOCK4 Gene

Regulatory Elements for DOCK4 Gene

Enhancers for DOCK4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DOCK4 on UCSC Golden Path with GeneCards custom track

Promoters for DOCK4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOCK4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DOCK4 Gene

Chromosome:
7
Start:
111,726,108 bp from pter
End:
112,206,411 bp from pter
Size:
480,304 bases
Orientation:
Minus strand

Genomic View for DOCK4 Gene

Genes around DOCK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK4 Gene

Proteins for DOCK4 Gene

  • Protein details for DOCK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1I0-DOCK4_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 4
    Protein Accession:
    Q8N1I0
    Secondary Accessions:
    • O14584
    • O94824
    • Q8NB45

    Protein attributes for DOCK4 Gene

    Size:
    1966 amino acids
    Molecular mass:
    225206 Da
    Quaternary structure:
    • Interacts with the SH3 domain of CRK. Interacts with nucleotide-free Rap1. Interacts with FASLG. Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2.
    Miscellaneous:
    • Injection of wild-type protein suppresses tumor invasion in osteosarcoma mouse cell lines while it is not the case with the Leu-1718 variant.
    SequenceCaution:
    • Sequence=BAC03696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DOCK4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOCK4 Gene

Proteomics data for DOCK4 Gene at MOPED

Post-translational modifications for DOCK4 Gene

  • Ubiquitination at Lys 101
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DOCK4 Gene

Domains & Families for DOCK4 Gene

Protein Domains for DOCK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1I0

UniProtKB/Swiss-Prot:

DOCK4_HUMAN :
  • The DHR-2 domain probably mediates the GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain probably mediates the GEF activity.
  • Contains 1 DHR-1 domain.
  • Contains 1 DHR-2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK4: view

No data available for Gene Families for DOCK4 Gene

Function for DOCK4 Gene

Molecular function for DOCK4 Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.

Gene Ontology (GO) - Molecular Function for DOCK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0030165 PDZ domain binding IPI 16464467
genes like me logo Genes that share ontologies with DOCK4: view
genes like me logo Genes that share phenotypes with DOCK4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOCK4 Gene

Localization for DOCK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK4 Gene

Cell membrane. Cell projection. Cytoplasm, cytosol. Note=Colocalizes with EPHA2, RhoG and CTTN/cortactin at the tip of protrusions in migrating cells. {ECO:0000269 PubMed:20679435}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOCK4 Gene COMPARTMENTS Subcellular localization image for DOCK4 gene
Compartment Confidence
cytosol 5
plasma membrane 3
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DOCK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with DOCK4: view

Pathways & Interactions for DOCK4 Gene

genes like me logo Genes that share pathways with DOCK4: view

Pathways by source for DOCK4 Gene

1 KEGG pathway for DOCK4 Gene

Gene Ontology (GO) - Biological Process for DOCK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0060326 cell chemotaxis IMP 20679435
genes like me logo Genes that share ontologies with DOCK4: view

No data available for SIGNOR curated interactions for DOCK4 Gene

Drugs & Compounds for DOCK4 Gene

(3) Drugs for DOCK4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK4: view

Transcripts for DOCK4 Gene

Unigene Clusters for DOCK4 Gene

Dedicator of cytokinesis 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1:
SP2:
SP3:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b ^ 48 ^ 49 ^ 50 ^
SP1: - -
SP2: - -
SP3:

ExUns: 51 ^ 52a · 52b · 52c
SP1:
SP2:
SP3:

Relevant External Links for DOCK4 Gene

GeneLoc Exon Structure for
DOCK4
ECgene alternative splicing isoforms for
DOCK4

Expression for DOCK4 Gene

mRNA expression in normal human tissues for DOCK4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOCK4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for DOCK4 Gene

This gene is overexpressed in Cervix (25.1) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOCK4 Gene



SOURCE GeneReport for Unigene cluster for DOCK4 Gene Hs.654652

mRNA Expression by UniProt/SwissProt for DOCK4 Gene

Q8N1I0-DOCK4_HUMAN
Tissue specificity: Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.
genes like me logo Genes that share expression patterns with DOCK4: view

Protein tissue co-expression partners for DOCK4 Gene

Primer Products

Orthologs for DOCK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOCK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOCK4 35
  • 93 (n)
  • 98.47 (a)
DOCK4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOCK4 35
  • 92.12 (n)
  • 97.34 (a)
DOCK4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dock4 35
  • 90.25 (n)
  • 97.81 (a)
Dock4 16
Dock4 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DOCK4 35
  • 99.71 (n)
  • 99.95 (a)
DOCK4 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOCK4 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves DOCK4 35
  • 83 (n)
  • 93.1 (a)
DOCK4 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOCK4 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dock4 35
  • 78.83 (n)
  • 88.47 (a)
zebrafish
(Danio rerio)
Actinopterygii dock4b 35
  • 72.54 (n)
  • 80.64 (a)
DOCK4 (2 of 2) 36
  • 73 (a)
OneToMany
dock4b 36
  • 78 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta spg 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ced-5 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 16 (a)
OneToMany
Species with no ortholog for DOCK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOCK4 Gene

ENSEMBL:
Gene Tree for DOCK4 (if available)
TreeFam:
Gene Tree for DOCK4 (if available)

Paralogs for DOCK4 Gene

Paralogs for DOCK4 Gene

genes like me logo Genes that share paralogs with DOCK4: view

Variants for DOCK4 Gene

Sequence variations from dbSNP and Humsavar for DOCK4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_015823 -
VAR_015824 -
VAR_015825 -
VAR_015826 -
rs150569245 - 111,739,142(+) CGAAG(A/C/G)CTCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DOCK4 Gene

Variant ID Type Subtype PubMed ID
nsv5901 CNV Loss 18451855
esv2735036 CNV Deletion 23290073
esv2621161 CNV Deletion 19546169
esv2670440 CNV Deletion 23128226
esv2735037 CNV Deletion 23290073
esv2422365 CNV Duplication 17116639
nsv464689 CNV Gain 19166990
nsv889054 CNV Loss 21882294
esv2662534 CNV Deletion 23128226
esv2735038 CNV Deletion 23290073
esv9335 CNV Loss 19470904
esv2735039 CNV Deletion 23290073
nsv516034 CNV Loss 19592680
nsv824270 CNV Loss 20364138

Variation tolerance for DOCK4 Gene

Residual Variation Intolerance Score: 5.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOCK4 Gene

Human Gene Mutation Database (HGMD)
DOCK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK4 Gene

Disorders for DOCK4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DOCK4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dyslexia
reading disorder
  • specific reading disorder
intraductal papilloma
  • ductal papilloma
- elite association - COSMIC cancer census association via MalaCards
Search DOCK4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DOCK4

Genetic Association Database (GAD)
DOCK4
Human Genome Epidemiology (HuGE) Navigator
DOCK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOCK4
genes like me logo Genes that share disorders with DOCK4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOCK4 Gene

Publications for DOCK4 Gene

  1. DOCK4, a GTPase activator, is disrupted during tumorigenesis. (PMID: 12628187) Yajnik V. … Haber D.A. (Cell 2003) 2 3 4 67
  2. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3
  3. TGF-I^/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis. (PMID: 25644601) Yu J.R. … Van Aelst L. (Genes Dev. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. (PMID: 26129894) Abraham S. … Mavria G. (Nat Commun 2015) 3

Products for DOCK4 Gene

Sources for DOCK4 Gene

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