Aliases for DOCK2 Gene
External Ids for DOCK2 Gene
Previous GeneCards Identifiers for DOCK2 Gene
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
GeneCards Summary for DOCK2 Gene
DOCK2 (Dedicator Of Cytokinesis 2) is a Protein Coding gene. Diseases associated with DOCK2 include Immunodeficiency 40 and Dock2 Deficiency. Among its related pathways are Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters and Infectious disease. GO annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK5.
UniProtKB/Swiss-Prot for DOCK2 Gene
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.