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DOCK2 Gene

protein-coding   GIFtS: 66
GCID: GC05P169064

Dedicator Of Cytokinesis 2

(Previous name: dedicator of cyto-kinesis 2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dedicator Of Cytokinesis 21 2
Dedicator Of Cyto-Kinesis 21 2
Dedicator Of Cytokinesis Protein 22
KIAA02093

External Ids:    HGNC: 29881   Entrez Gene: 17942   Ensembl: ENSG000001345167   OMIM: 6031225   UniProtKB: Q926083   

Export aliases for DOCK2 gene to outside databases

Previous GC identifers: GC05P169299 GC05P169767 GC05P168999 GC05P169045 GC05P168996 GC05P164162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOCK2 Gene:
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic
cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton
required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment
in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts,
suggesting that this gene may be a target for controlling transplant rejection. (provided by RefSeq, Oct 2011)

GeneCards Summary for DOCK2 Gene:
DOCK2 (dedicator of cytokinesis 2) is a protein-coding gene. GO annotations related to this gene include T cell receptor binding and Rac GTPase activator activity. An important paralog of this gene is DOCK4.

UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608
Function: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines.
Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which
exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of
RAC2

Gene Wiki entry for DOCK2 (Dock2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOCK2 gene promoter:
         USF1   AML1a   NRSF form 1   USF2   USF-1:USF-2   NRSF form 2   E2F-1   USF-1   c-Myb   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOCK2 promoter sequence
   Search Chromatin IP Primers for DOCK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q35.1

DOCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P169064:  view genomic region     (about GC identifiers)

Start:
169,064,251 bp from pter      End:
169,510,386 bp from pter
Size:
446,136 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 2  
Size: 1830 amino acids; 211948 Da
Subunit: Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z
Sequence caution: Sequence=BAA13200.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for DOCK2:
2RQR (3D)        2YIN (3D)        3A98 (3D)        3B13 (3D)    
Secondary accessions: Q2M3I0 Q96AK7
Alternative splicing: 2 isoforms:  Q92608-1   Q92608-2   (Splicing donor and acceptor sites between exon 6 and exon 7 are not canonical. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK2: NX_Q92608

Explore proteomics data for DOCK2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys199, Lys268, Lys371, Lys410, Lys485, Lys494, Lys622, Lys835, Lys863, Lys1076,
                                 Lys1127, Lys1184, Lys1212, Lys1424, Lys1435, Lys1474, Lys1615, Lys1726, Lys1808, Lys1814 (see all 21)
  • Modification sites at PhosphoSitePlus

  • See DOCK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004937.1  
    ENSEMBL proteins: 
     ENSP00000256935   ENSP00000428850   ENSP00000429283   ENSP00000428841   ENSP00000393451  
     ENSP00000438827  
    Reactome Protein details: Q92608

    DOCK2 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for DOCK2
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    Novus Biologicals DOCK2 Protein
    Novus Biologicals DOCK2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOCK2

     
    Search eBioscience for Proteins for DOCK2 

     
    antibodies-online proteins for DOCK2 (2 products) 

     
    antibodies-online peptides for DOCK2

    DOCK2 Antibody Products:

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    antibodies-online antibodies for DOCK2 (25 products) 

    DOCK2 Assay Products:

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    Cloud-Clone Corp. ELISAs for DOCK2
    Cloud-Clone Corp. CLIAs for DOCK2
    Search eBioscience for ELISAs for DOCK2 
    antibodies-online kits for DOCK2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR011511 SH3_2
     IPR027007 DHR-1_domain
     IPR026791 DOCK
     IPR026799 DOCK_2
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q92608

    ProtoNet protein and cluster: Q92608

    3 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB010703 Dedicator of cytokinesis
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608
    Domain: The DHR-2 domain may mediate the GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with DOCK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOCK2_HUMAN, Q92608
    Function: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines.
    Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which
    exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of
    RAC2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005488binding ----
    GO:0005515protein binding IPI12134158
    GO:0009055electron carrier activity ----
    GO:0020037heme binding ----
         
    Find genes that share ontologies with DOCK2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DOCK2:
     Decreased mitotic index 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Dock2):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis 

    Find genes that share phenotypes with DOCK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dock2tm1Tsas for DOCK2

       genOway: Develop your customized and physiologically relevant rodent model for DOCK2

    miRNA
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    Block miRNA regulation of human, mouse, rat DOCK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOCK2 (see all 17):
    hsa-miR-548j hsa-miR-548w hsa-miR-3163 hsa-miR-4291 hsa-miR-559 hsa-miR-3135 hsa-miR-548i hsa-miR-548h
    SwitchGear 3'UTR luciferase reporter plasmidDOCK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DOCK2
    Predesigned siRNA for gene silencing in human, mouse, rat DOCK2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: DOCK2 (NM_004946)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DOCK2_HUMAN, Q92608: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes
    with F-actin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0012505endomembrane system IEA--
    GO:0016020membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with DOCK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOCK2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
    The role of Nef in HIV-1 replication and disease pathogenesis0.76
    Nef and signal transduction0.00
    2HIV Life Cycle
    HIV Infection0.62
    Host Interactions of HIV factors0.60
    3Development HGF signaling pathway
    Development HGF signaling pathway0.45
    4Hemostasis
    Hemostasis0.43
    5Chemokine Signaling
    Chemokine signaling pathway0.33


    Find genes that share SuperPaths with DOCK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DOCK2
        Development HGF signaling pathway

    1 BioSystems Pathway for DOCK2
        Regulation of RAC1 activity

    2 Reactome Pathways for DOCK2
        Nef and signal transduction
    Factors involved in megakaryocyte development and platelet production


    2 Kegg Pathways  (Kegg details for DOCK2):
        Chemokine signaling pathway
    Fc gamma R-mediated phagocytosis

        Pathway & Disease-focused RT2 Profiler PCR Array including DOCK2: 
              Inflammatory Response & Autoimmunity 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DOCK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DOCK2 (Q926081, 2, 3 ENSP000002569354) via UniProtKB, MINT, STRING, and/or I2D (see all 610)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC1P630001, 2, 3, ENSP000003484614EBI-448771,EBI-413628 MINT-7306003 MINT-7305987 I2D: score=5 STRING: ENSP00000348461
    ELMO1Q925562, 3, ENSP000003121854MINT-7306003 I2D: score=2 STRING: ENSP00000312185
    CRKLP461093, ENSP000003463004I2D: score=3 STRING: ENSP00000346300
    RAC2P151533, ENSP000002490714I2D: score=3 STRING: ENSP00000249071
    VAV1P154983, ENSP000003022694I2D: score=3 STRING: ENSP00000302269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001766membrane raft polarization IEA--
    GO:0001768establishment of T cell polarity IEA--
    GO:0001771immunological synapse formation IEA--
    GO:0002277myeloid dendritic cell activation involved in immune response ISS--
    GO:0006935chemotaxis IEA--

    Find genes that share ontologies with DOCK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOCK2

    3 HMDB Compounds for DOCK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DOCK2 gene: 
    NM_004946.2  

    Unigene Cluster for DOCK2:

    Dedicator of cytokinesis 2
    Hs.586174  [show with all ESTs]
    Unigene Representative Sequence: NM_004946
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256935(uc003maf.3 uc011der.2) ENST00000522138 ENST00000524185(uc010jjl.1)
    ENST00000523684 ENST00000519734 ENST00000519223 ENST00000520908(uc010jjm.3)
    ENST00000520836 ENST00000520181 ENST00000519628 ENST00000523351 ENST00000522994
    ENST00000433448 ENST00000518056 ENST00000520450(uc003mah.3) ENST00000519868
    ENST00000540750
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DOCK2 (see all 17):
    hsa-miR-548j hsa-miR-548w hsa-miR-3163 hsa-miR-4291 hsa-miR-559 hsa-miR-3135 hsa-miR-548i hsa-miR-548h
    SwitchGear 3'UTR luciferase reporter plasmidDOCK2 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOCK2
      QuantiTect SYBR Green Assays in human, mouse, rat DOCK2
      QuantiFast Probe-based Assays in human, mouse, rat DOCK2

    Additional mRNA sequence: 

    AK128107.1 BC016996.1 BC035613.1 BC084556.1 BC104900.1 BC113457.1 BC143358.1 D86964.1 

    8 DOTS entries:

    DT.445570  DT.86837400  DT.99969909  DT.120870237  DT.40112931  DT.86841153  DT.91977500  DT.99999258 

    Selected AceView cDNA sequences (see all 123):

    BM720910 CD689721 AI660773 BM452581 AA812175 AA311420 AA360867 BQ059375 
    AA748841 AI660796 BC016996 AK128449 D86964 AK128107 AL560031 BC035613 
    BU624362 AI904057 BQ063157 BX484435 BQ214354 BG036603 BM676997 BQ055414 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DOCK2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a ·
    SP1:                                                                                      -                                                                 -   
    SP2:                                                                                                        -                                               -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 26b ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39a · 39b ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45a · 45b ^ 46 ^
    SP1:                                                  -                                         -                                               -               
    SP2:                    -                             -                                         -                                               -               
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for DOCK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DOCK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGATGAGG
    DOCK2 Expression
    About this image


    DOCK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Hematopoietic Stem Cells Thymus
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DOCK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOCK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.586174

    UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608
    Tissue specificity: Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood
    leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small
    intestine and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including DOCK2: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DOCK2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock21 , 5 dedicator of cyto-kinesis 21, 5 89.7(n)1
    95.19(a)1
      11 (19.68 cM)5
    941761  NM_033374.31  NP_203538.21 
     342268155 
    chicken
    (Gallus gallus)
    Aves DOCK21 dedicator of cytokinesis 2 76.63(n)
    86.14(a)
      427612  XM_425184.4  XP_425184.4 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK26
    dedicator of cytokinesis 2
    83(a)
    1 ↔ 1
    2(120131201-120505507)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dock21 dedicator of cytokinesis 2 73.12(n)
    80.31(a)
      100497849  XM_002937730.2  XP_002937776.2 
    zebrafish
    (Danio rerio)
    Actinopterygii DOCK26
    dedicator of cytokinesis 2
    65(a)
    1 ↔ 1
    14(1444373-1582759) ENSDARG00000076562
    fruit fly
    (Drosophila melanogaster)
    Insecta mbc3 larval visceral muscle development 40(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ced-56
    Protein CED-5 (ced-5) mRNA, complete cds
    26(a)
    1 → many
    IV(10484110-10492952) WBGene00000419
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Protein of unknown function with similarity to hum...
    15(a)
    1 → many
    XII(965897-971695) YLR422W


    ENSEMBL Gene Tree for DOCK2 (if available)
    TreeFam Gene Tree for DOCK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOCK2 gene
    DOCK42  DOCK32  DOCK12  DOCK52  
    7 SIMAP similar genes for DOCK2 using alignment to 7 protein entries:     DOCK2_HUMAN (see all proteins):
    DKFZp779M164    DKFZp781J211    DOCK1    DOCK5    DOCK3    SORBS3
    DOCK4

    Find genes that share paralogs with DOCK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOCK2 (see all 7068)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893675201,2
    --169062321(+) TTTTGC/TTTTCT 1 -- us2k10--------
    rs1806950941,2
    --169062599(+) ATTAGC/TTGACA 1 -- us2k10--------
    rs720970011,2
    C--169062762(+) ATGTG-/TATATAT 1 -- us2k10--------
    rs1506131871,2
    C--169062765(+) GTATA-/TATATATATATATA
    TGCATATATGTATGTG
    TATAT
    1 -- cds10--------
    rs1455364501,2
    C--169062797(+) ATGTG-/TATATA
            
    TATAT
    1 -- cds10--------
    rs681823501,2
    C--169062798(+) TGTGT-/TA/   
      TATATA
    ATATA
    2 -- us2k1 cds10--------
    rs595946401,2
    C--169062802(+) TATAT-/ATATAT/ATATATATATGCA
    TATATGTATGTGTATATATATAT
    GCATA
    2 -- cds10--------
    rs356371581,2
    C--169062838(+) TATGT-/ATG   
      T
    /TATG
    GTATA
    1 -- us2k10--------
    rs1872177951,2
    --169062860(+) ATGCAC/TATATG 1 -- us2k10--------
    rs721136281,2
    C--169062874(+) GTATG-/TATGTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DOCK2 (169064251 - 169314251 bp, first 250kb of DOCK2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DOCK2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731056CNV Deletion23290073
    esv2731060CNV Deletion23290073
    dgv1055e199CNV Deletion23128226
    esv2678882CNV Deletion23128226
    esv2731058CNV Deletion23290073
    esv2731059CNV Deletion23290073
    esv2731057CNV Deletion23290073
    esv988430CNV Insertion20482838
    esv273090CNV Insertion20981092
    nsv328128CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOCK2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603122    OMIM disorders: --


    Find genes that share disorders with DOCK2           About GenesLikeMe

    Genetic Association Database (GAD): DOCK2
    Human Genome Epidemiology (HuGE) Navigator: DOCK2 (5 documents)

    Export disorders for DOCK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOCK2 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with DOCK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 2, 9 Nishihara H....Tanaka S. (Blood 2002)
    2. Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. (PubMed id 10559471)1, 2, 9 Nishihara H.... Matsuda M. (Biochim. Biophys. Acta 1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2 Cote J.-F. and Vuori K. (J. Cell Sci. 2002)
    10. DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription. (PubMed id 12176041)1, 2 Nishihara H....Tanaka S. (Biochem. Biophys. Res. Commun. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1794 HGNC: 2988 AceView: DOCK2 Ensembl:ENSG00000134516 euGenes: HUgn1794
    ECgene: DOCK2 Kegg: 1794 H-InvDB: DOCK2

    (According to HUGE)
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    HUGE: KIAA0209

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOCK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOCK2 gene:
    Search GeneIP for patents involving DOCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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