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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DOCK2 Gene

protein-coding GIFtS: 65
GCID: GC05P169064

dedicator of cytokinesis 2

(Previous name: dedicator of cyto-kinesis 2 )

Explore 6 diseases affiliated with
DOCK2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 2¹ ²
Dedicator Of Cyto-Kinesis 2¹ ²
KIAA0209¹ ³
Dedicator Of Cytokinesis Protein 2²

External Ids:	HGNC: 2988¹	Entrez Gene: 1794²	Ensembl: ENSG00000134516⁷	OMIM: 603122⁵	UniProtKB: Q92608³

Export aliases for DOCK2 gene to outside databases

Previous GC identifers: GC05P169299 GC05P169767 GC05P168999 GC05P169045 GC05P168996 GC05P164162

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOCK2:

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic

cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton

required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in

the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting

that this gene may be a target for controlling transplant rejection. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608

Function: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines.

Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges

bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2

Gene Wiki entry for DOCK2 (Dock2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DOCK2 gene promoter:
USF1 AML1a NRSF form 1 USF2 USF-1:USF-2 NRSF form 2 E2F-1 USF-1 c-Myb ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK2 promoter sequence

Search SABiosciences Chromatin IP Primers for DOCK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.1 Ensembl cytogenetic band: 5q35.1 HGNC cytogenetic band: 5q35.1

DOCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P169064: view genomic region (about GC identifiers)

Start:	169,064,251 bp from pter	End:	169,510,386 bp from pter
Size:	446,136 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608 (See protein sequence)

Recommended Name: Dedicator of cytokinesis protein 2

Size: 1830 amino acids; 211948 Da

Subunit: Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z

Subcellular location: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Colocalizes with

F-actin

Sequence caution: Sequence=BAA13200.1; Type=Erroneous initiation;

4 PDB 3D structures from and Proteopedia for DOCK2:

2RQR (3D)

2YIN (3D)

3A98 (3D)

3B13 (3D)

Secondary accessions: Q2M3I0 Q96AK7

Alternative splicing: 2 isoforms: Q92608-1 Q92608-2 (Splicing donor and acceptor sites between exon 6 and exon 7 are not canonical. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK2: NX_Q92608

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92608

DOCK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004937.1

ENSEMBL proteins:

ENSP00000256935 ENSP00000428850 ENSP00000429283 ENSP00000428841 ENSP00000393451

ENSP00000438827

Reactome Protein details: Q92608
Human Recombinant Protein Products:

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	Novus Biologicals DOCK2 Protein Novus Biologicals DOCK2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DOCK2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IEA	--
GO:0005886	plasma membrane	--	--

DOCK2 for ontologies About GeneDecksing

DOCK2 Antibody Products:

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	Uscn ELISAs and CLIAs for DOCK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DOCK2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR011511 SH3_2

IPR027007 DOCK-C2

IPR026791 DOCK

IPR026799 DOCK_A

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry Q92608

ProtoNet protein and cluster: Q92608

3 Blocks protein families:

IPB001452 SH3 domain signature

IPB010703 Dedicator of cytokinesis

IPB011511 Variant SH3

UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608

Domain: The DHR-2 domain may mediate the GEF activity (By similarity)

Similarity: Belongs to the DOCK family

Similarity: Contains 1 DHR-1 domain

Similarity: Contains 1 DHR-2 domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608

Function: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines.

Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges

bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2

miRNA Products:		OriGene 3'-UTR Clone: DOCK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK2 (see all 17):
		hsa-miR-548j hsa-miR-548w hsa-miR-3163 hsa-miR-4291 hsa-miR-559 hsa-miR-3135 hsa-miR-548i hsa-miR-548h

		SwitchGear 3'UTR luciferase reporter plasmid: DOCK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK2 (see all 4) OriGene shRNA RFP: DOCK2 OriGene siRNA: DOCK2
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DOCK2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK2

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	--	--
GO:0005525	GTP binding	--	--
GO:0009055	electron carrier activity	IEA	--
GO:0020037	heme binding	IEA	--
GO:0030675	Rac GTPase activator activity	IEA	--

DOCK2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DOCK2:

Decreased mitotic index

Animal Models:
Mouse knock-out Dock2^tm1Tsas for DOCK2
6 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Dock2):

cellular	hematopoietic system	homeostasis/metabolism	immune system	mortality/aging
no phenotypic analysis

DOCK2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development HGF signaling pathway

Development HGF signaling pathway

1.00

Development_HGF signaling pathway

0.78

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

1.00

Disease

Disease

1.00

Nef and signal transduction

Nef and signal transduction

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for DOCK2

Development HGF signaling pathway

1 GeneGo (Thomson Reuters) Pathway for DOCK2

Development HGF signaling pathway

1 BioSystems Pathway for DOCK2

Regulation of RAC1 activity

5/7 Reactome Pathways for DOCK2 (see all 7)

	Hemostasis
	Nef and signal transduction
	HIV Infection
	Factors involved in megakaryocyte development and platelet production
	The role of Nef in HIV-1 replication and disease pathogenesis

2 Kegg Pathways (Kegg details for DOCK2):

	Chemokine signaling pathway
	Fc gamma R-mediated phagocytosis

DOCK2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DOCK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/573 Interacting proteins for DOCK2 (Q92608^{2, 3} ENSP00000256935⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 573)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAC1	P63000²^,³, ENSP00000348461⁴	MINT-7306003 MINT-7305987 I2D: score=5 STRING: ENSP00000348461
ELMO1	Q92556²^,³, ENSP00000312185⁴	MINT-7306003 I2D: score=2 STRING: ENSP00000312185
CRKL	P46109³, ENSP00000346300⁴	I2D: score=3 STRING: ENSP00000346300
RAC2	P15153³, ENSP00000249071⁴	I2D: score=3 STRING: ENSP00000249071
VAV1	P15498³, ENSP00000302269⁴	I2D: score=3 STRING: ENSP00000302269

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001766	membrane raft polarization	IEA	--
GO:0001768	establishment of T cell polarity	IEA	--
GO:0001771	immunological synapse formation	IEA	--
GO:0002277	myeloid dendritic cell activation involved in immune response	ISS	--
GO:0006935	chemotaxis	IEA	--

DOCK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DOCK2

3 HMDB Compounds for DOCK2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about DOCK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DOCK2 gene:

NM_004946.2

Unigene Cluster for DOCK2:

Dedicator of cytokinesis 2

Hs.586174 [show with all ESTs]

Unigene Representative Sequence: NM_004946

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000256935(uc003maf.3 uc011der.2) ENST00000522138 ENST00000524185(uc010jjl.1)

ENST00000523684 ENST00000519734 ENST00000519223 ENST00000520908(uc010jjm.3)

ENST00000520836 ENST00000520181 ENST00000519628 ENST00000523351 ENST00000522994

ENST00000433448 ENST00000518056 ENST00000520450(uc003mah.3) ENST00000519868

ENST00000540750

miRNA Products:		OriGene 3'-UTR Clone: DOCK2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK2
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK2 (see all 17):
		hsa-miR-548j hsa-miR-548w hsa-miR-3163 hsa-miR-4291 hsa-miR-559 hsa-miR-3135 hsa-miR-548i hsa-miR-548h

		SwitchGear 3'UTR luciferase reporter plasmid: DOCK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK2 (see all 4) OriGene shRNA RFP: DOCK2 OriGene siRNA: DOCK2
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		GenScript: all cDNA clones in your preferred vector: DOCK2 (NM_004946)
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Additional cDNA sequence:

AK128107.1 BC016996.1 BC035613.1 BC084556.1 BC104900.1 BC113457.1 BC143358.1 D86964.1

8 DOTS entries:

DT.445570 DT.86837400 DT.99969909 DT.120870237 DT.40112931 DT.86841153 DT.91977500 DT.99999258

24/123 AceView cDNA sequences (see all 123):

BM452581 AI660773 AA812175 AA311420 AA360867 BC016996 BQ059375 AI660796

AA748841 CD689721 BM720910 BX089838 BV201512 AI971013 AK130744 BQ060695

AA281114 AI472166 BX482554 BQ052245 AI384045 BI029233 CA425356 BU071590

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK2 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26a	·
SP1:																													-																						-
SP2:																																			-																-
SP3:
SP4:
SP5:

ExUns:	26b	^	27	^	28a	·	28b	^	29a	·	29b	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39a	·	39b	^	40a	·	40b	^	41	^	42	^	43	^	44	^	45a	·	45b	^	46	^
SP1:																	-														-																-
SP2:							-										-														-																-
SP3:
SP4:
SP5:

ExUns:	47	^	48	^	49	^	50	^	51	^	52	^	53	^	54
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DOCK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DOCK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGATGAGG

About this image

DOCK2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DOCK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOCK2

SOURCE GeneReport for Unigene cluster: Hs.586174

UniProtKB/Swiss-Prot: DOCK2_HUMAN, Q92608

Tissue specificity: Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and

expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon

SABiosciences Expression via Pathway-Focused PCR Array including DOCK2:

Inflammatory Response & Autoimmunity 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DOCK2 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dock2^{1 , 5}	dedicator of cyto-kinesis 2^{1, 5}	89.66(n)¹ 95.19(a)¹		11 (19.68 cM)⁵ 94176¹ NM_033374.2¹ NP_203538.2¹ 34226815⁵
chicken (Gallus gallus)	Aves	DOCK2¹	dedicator of cytokinesis 2	76.71(n) 86.32(a)		427612 XM_425184.3 XP_425184.3
lizard (Anolis carolinensis)	Reptilia	DOCK2⁶ DOCK1⁶	--	84(a) 71(a)	many → 1 many → 1	2(120141163-120254918) 2(120378550-120496558)
zebrafish (Danio rerio)	Actinopterygii	CABZ01064234.1⁶	--	65(a)	1 ↔ 1	14(1444373-1582759)
fruit fly (Drosophila melanogaster)	Insecta	mbc³	larval visceral muscle development	40(a)		--
worm (Caenorhabditis elegans)	Secernentea	ced-5⁶	CEll Death abnormality family member (ced-5)	23(a)	possible ortholog	IV(10484090-10492932)

ENSEMBL Gene Tree for DOCK2 (if available)
TreeFam Gene Tree for DOCK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DOCK2 gene

DOCK3² DOCK4² DOCK1² DOCK5²

7 SIMAP similar genes for DOCK2 using alignment to 7 protein entries: DOCK2_HUMAN (see all proteins):

DKFZp779M164 DKFZp781J211 DOCK1 DOCK5 DOCK3 SORBS3

DOCK4

DOCK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74500423^1,2		--	164470140(+)	`GAACCG/AACTGT`	1	--	ds500¹		1		EA	120
rs59931208^1,2	F,	--	164470304(+)	`TCAATA/GATACC`	1	--	ds500¹		1		WA	118
rs59205843^1,2	C,	--	164472292(+)	`GCAAAC/TTCACT`	1	--	us2k¹		2		WA	120
rs35392205^1,2	F,	--	164472327(+)	`AGATTG/ATGAAG`	1	--	us2k¹		1		WA	118
rs116361603^1,2	C,F,	--	164472447(+)	`TCTCAT/CCCATT`	1	--	us2k¹		1		WA	118
rs12655735^1,2	H	--	164472736(+)	`CTTTAG/AGGTGA`	1	--	us2k¹		4		NS EA	420
rs62386597^1,2		--	164473137(+)	`CATTCG/AGTACA`	1	--	us2k¹		1		NA	2
rs79550508^1,2	F,	--	164473431(+)	`TTGCAC/TCTTTC`	1	--	us2k¹		1		EA	120
rs71575581^1,2	C,	--	164562487(+)	`AGCAC-/AAAAAC`	1	--	int¹		1		NA	2
rs189367520^1,2		--	169062321(+)	`TTTTGC/TTTTCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DOCK2 (169064251 - 169314251 bp, first 250kb of DOCK2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for DOCK2
3 CNVs: 81114 6465 93347
6 Indels: 93348 81115 60571 12777 81116 64365

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DOCK2 for disorders           About GeneDecksing

OMIM gene information: 603122    OMIM disorders: --

6 diseases for DOCK2:    About MalaCards

b-cell lymphomas alzheimer's disease prostate cancer prostatitis

immunodeficiency leukemia

Human Genome Epidemiology (HuGE) Navigator: DOCK2 (5 documents)

Export disorders for DOCK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DOCK2 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with DOCK2)

Utopia: connect your pdf to the dynamic
world of online information

DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)^{1, 2, 9} Nishihara H....Tanaka S. (2002)
Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins. (PubMed id 10559471)^{1, 2, 9} Nishihara H.... Matsuda M. (1999)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)^{1, 2} Cote J.-F. and Vuori K. (2002)
DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription. (PubMed id 12176041)^{1, 2} Nishihara H....Tanaka S. (2002)
Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2} Nagase T....Nomura N. (1996)
DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1. (PubMed id 12829596)^{1, 9} Sanui T....Fukui Y. (2003)
Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors. (PubMed id 18056264)^{1, 9} Kwofie M.A. and Skowronski J. (2008)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1794	HGNC: 2988	AceView: DOCK2	Ensembl:ENSG00000134516	euGenes: HUgn1794
ECgene: DOCK2	Kegg: 1794	H-InvDB: DOCK2

(According to HUGE)
About This Section

HUGE: KIAA0209

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DOCK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DOCK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DOCK2 gene:
Search GeneIP for patents involving DOCK2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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