External Ids for DOCK2 Gene
The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]
GeneCards Summary for DOCK2 Gene
DOCK2 (Dedicator Of Cytokinesis 2) is a Protein Coding gene. Among its related pathways are Disease and Hemostasis. GO annotations related to this gene include T cell receptor binding. An important paralog of this gene is DOCK5.
UniProtKB/Swiss-Prot for DOCK2 Gene
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.