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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOCK11 Gene

protein-coding   GIFtS: 55
GCID: GC0XP117629

Dedicator Of Cytokinesis 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 111 2     BB128O4.1.1 (Novel Protein)2
zizimin21 2     Dedicator Of Cytokinesis Protein 112
ACG2 3     zizimin-22
ZIZ22 3     Zizimin-23
Activated Cdc42-Associated Guanine Nucleotide Exchange Factor, ACG2     Activated Cdc42-Associated Guanine Nucleotide Exchange Factor3
bB128O4.12     

External Ids:    HGNC: 234831   Entrez Gene: 1398182   Ensembl: ENSG000001472517   OMIM: 3006815   UniProtKB: Q5JSL33   

Export aliases for DOCK11 gene to outside databases

Previous GC identifers: GC0XP116476 GC0XP116383 GC0XP117411 GC0XP117513 GC0XP107125


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DOCK11 Gene: 
DOCK11 (dedicator of cytokinesis 11) is a protein-coding gene. Diseases associated with DOCK11 include atelosteogenesis, and achondrogenesis, and among its related super-pathways are G-protein signaling Regulation of CDC42 activity and Platelet activation, signaling and aggregation. GO annotations related to this gene include Rho GTPase binding and phospholipid binding. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot: DOC11_HUMAN, Q5JSL3
Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By
similarity)

Gene Wiki entry for DOCK11 (Dock11) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOCK11 gene promoter:
         Nkx3-1   Nkx3-1 v4   GATA-3   STAT5A   Nkx3-1 v1   Nkx2-5   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOCK11 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOCK11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

DOCK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP117629:  view genomic region     (about GC identifiers)

Start:
117,629,861 bp from pter      End:
117,820,126 bp from pter
Size:
190,266 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOC11_HUMAN, Q5JSL3 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 11  
Size: 2073 amino acids; 237671 Da
Subunit: Interacts with CDC42 (By similarity)
Miscellaneous: 'Zizim' means 'spike' in Hebrew
Sequence caution: Sequence=BAB71253.1; Type=Erroneous initiation; Sequence=BAC86230.1; Type=Erroneous initiation;
Sequence=CAI41407.1; Type=Erroneous gene model prediction; Sequence=CAI41411.1; Type=Erroneous gene model
prediction;
Secondary accessions: A6NMF0 Q66M66 Q6ZUJ5 Q86VU8 Q96MN3

Explore the universe of human proteins at neXtProt for DOCK11: NX_Q5JSL3

Explore proteomics data for DOCK11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JSL3

  • DOCK11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DOCK11 Protein Expression
    REFSEQ proteins: NP_653259.3  
    ENSEMBL proteins: 
     ENSP00000276204   ENSP00000276202  
    Reactome Protein details: Q5JSL3
    Human Recombinant Protein Products for DOCK11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for DOCK11
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for DOCK11
    GenScript Custom Purified and Recombinant Proteins Services for DOCK11
    Novus Biologicals DOCK11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DOCK11 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    DOCK11 for ontologies           About GeneDecksing



    DOCK11 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for DOCK11 
    Cloud-Clone Corp. CLIAs for DOCK11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5/8 InterPro protein domains (see all 8):
     IPR021816 DOCK_C/D_N
     IPR027007 DHR-1_domain
     IPR026791 DOCK
     IPR001849 Pleckstrin_homology
     IPR026796 DOCK_D

    Graphical View of Domain Structure for InterPro Entry Q5JSL3

    ProtoNet protein and cluster: Q5JSL3

    1 Blocks protein domain: IPB010703 Dedicator of cytokinesis

    UniProtKB/Swiss-Prot: DOC11_HUMAN, Q5JSL3
    Domain: The DHR-2 domain is necessary for the GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 PH domain


    DOCK11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOC11_HUMAN, Q5JSL3
    Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By
    similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0017048Rho GTPase binding IEA--
         
    DOCK11 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DOCK11:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DOCK11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOCK11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOCK11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOCK11 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK11
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK11:
    hsa-miR-4324 hsa-miR-10b hsa-miR-128 hsa-miR-624* hsa-miR-3681* hsa-miR-10a hsa-miR-544b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidDOCK11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DOCK11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK11

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DOCK11

    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DOCK11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00
    2Platelet activation, signaling and aggregation
    Hemostasis0.43
    3Regulation of CDC42 activity
    Regulation of CDC42 activity
    4Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DOCK11
        G-protein signaling Regulation of CDC42 activity


    1 GeneGo (Thomson Reuters) Pathway for DOCK11
        G-protein signaling Regulation of CDC42 activity

    1 BioSystems Pathway for DOCK11
        Regulation of CDC42 activity

    2        Reactome Pathways for DOCK11
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    DOCK11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOCK11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for DOCK11 (Q5JSL33 ENSP000002762024) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    ATG4CQ96DT63I2D: score=1 
    CDC42ENSP000003144584STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0007596blood coagulation TAS--

    DOCK11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOCK11 (DOC11)

    1 HMDB Compound for DOCK11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about DOCK11 / DOC11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DOCK11 gene: 
    NM_144658.3  

    Unigene Cluster for DOCK11:

    Dedicator of cytokinesis 11
    Hs.368203  [show with all ESTs]
    Unigene Representative Sequence: NM_144658
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276204(uc004eqp.2 uc004eqq.2) ENST00000276202 ENST00000498252

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK11
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK11:
    hsa-miR-4324 hsa-miR-10b hsa-miR-128 hsa-miR-624* hsa-miR-3681* hsa-miR-10a hsa-miR-544b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmidDOCK11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DOCK11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK11
    Clone
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    OriGene clones in human, mouse for DOCK11 (see all 5)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOCK11 (NM_144658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK11
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DOCK11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOCK11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK11

    Additional mRNA sequence: 

    AK054649.1 AK056684.1 AK124735.1 AK125641.1 AY692226.1 BC035593.1 BC042053.1 BC047713.1 

    6 DOTS entries:

    DT.309892  DT.100804485  DT.99967465  DT.40240029  DT.95222537  DT.99949504 

    24/93 AceView cDNA sequences (see all 93):

    BG545840 AY692226 BM795650 AK124735 AK054649 BU102169 AK056684 AA384900 
    BC042053 AI361832 BU101811 AI742838 AW023994 CB270465 BU101810 AI923047 
    BC047713 AW574560 BP369093 NM_144658 BX102345 BQ879388 AW515289 CD369436 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOCK11 expression in normal human tissues (normalized intensities)      DOCK11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCCAACA
    DOCK11 Expression
    About this image


    DOCK11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle

    See DOCK11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOCK11

    SOURCE GeneReport for Unigene cluster: Hs.368203
        SABiosciences Custom PCR Arrays for DOCK11
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DOCK11 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock111 , 5 dedicator of cytokinesis 111, 5 91.01(n)1
    96.62(a)1
      X (20.35 cM)5
    759741  NM_001009947.31  NP_001009947.21 
     358888325 
    chicken
    (Gallus gallus)
    Aves DOCK111 dedicator of cytokinesis 11 76.17(n)
    83.14(a)
      422229  XM_003641136.1  XP_003641184.1 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK116
    dedicator of cytokinesis 11
    66(a)
    1 ↔ 1
    GL343403.1(13270-121161)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7996861 dedicator of cytokinesis 11-like 64.29(n)
    65.64(a)
      799686  NM_001202493.1  NP_001189422.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG425336
    --
    36(a)
    1 → many
    2L(7472513-7496307)
    worm
    (Caenorhabditis elegans)
    Secernentea F22G12.51 Protein F22G12.5 43.92(n)
    30.7(a)
      173181  NM_060906.4  NP_493307.3 


    ENSEMBL Gene Tree for DOCK11 (if available)
    TreeFam Gene Tree for DOCK11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOCK11 gene
    DOCK92  DOCK72  DOCK62  DOCK102  DOCK82  
    7 SIMAP similar genes for DOCK11 using alignment to 3 protein entries:     DOC11_HUMAN (see all proteins):
    DKFZp686N04132    Nbla10300    DRIP2    DOCK9    DOCK10    DKFZp781A1532
    DOCK10.2

    DOCK11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DOCK11
    PGOHUM00000247788


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2690 SNPs in DOCK11 are shown (see all 2690)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399941321,2
    C--117627998(+) ATTGGG/TAGTCT 1 -- us2k10--------
    rs1496665771,2
    --117628213(+) CAGAGG/TGTATG 1 -- us2k10--------
    rs580817311,2
    C,F--117628223(+) GAATTC/ATTGGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs605468661,2
    C,F--117628278(+) CAAAAC/ATAAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1828217811,2
    --117628387(+) TACTGA/CGAAGA 1 -- us2k10--------
    rs1136329491,2
    C--117628499(+) GTGCCT/CGATGG 1 -- us2k12Minor allele frequency- C:0.00NA CSA 2
    rs1425697811,2
    C--117628525(+) CTTTCA/GGAAGG 1 -- us2k10--------
    rs1877763461,2
    --117628795(+) AGGTGA/GGTGCA 1 -- us2k10--------
    rs735855491,2
    C--117629028(+) CCCGTC/GGGGGA 1 -- us2k10--------
    rs16406721,2
    C,F,A,H--117629292(-) CCTCCA/GCCCCG 1 -- us2k113Minor allele frequency- G:0.10MN NS EA 2144

    HapMap Linkage Disequilibrium report for DOCK11 (117629861 - 117820126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DOCK11:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1557323CNV Insertion17803354
    nsv510553CNV Loss20534489
    dgv527n21CNV Gain19592680
    nsv522227CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DOCK11
    DNA2.0 Custom Variant and Variant Library Synthesis for DOCK11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300681    OMIM disorders: --

    6 diseases for DOCK11:    About MalaCards
    atelosteogenesis    achondrogenesis    neuronal ceroid lipofuscinosis    gastritis
    glaucoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DOCK11:
    Neuronal ceroid lipofuscinosis

    DOCK11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DOCK11

    Export disorders for DOCK11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOCK11 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with DOCK11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. (PubMed id 16968698)1, 2 Lin Q.... Cerione R.A. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 3 Cote J.-F. and Vuori K. (2002)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    10. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 139818 HGNC: 23483 AceView: DOCK11 Ensembl:ENSG00000147251 euGenes: HUgn139818
    ECgene: DOCK11 H-InvDB: DOCK11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOCK11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DOCK11 gene:
    Search GeneIP for patents involving DOCK11

    GeneCards and IP:
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