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Aliases for DOCK11 Gene

Aliases for DOCK11 Gene

  • Dedicator Of Cytokinesis 11 2 3 5
  • Zizimin-2 3 4
  • Zizimin2 2 3
  • ZIZ2 3 4
  • ACG 3 4
  • Activated Cdc42-Associated Guanine Nucleotide Exchange Factor, ACG 3
  • Activated Cdc42-Associated Guanine Nucleotide Exchange Factor 4
  • BB128O4.1.1 (Novel Protein) 3
  • BB128O4.1 3

External Ids for DOCK11 Gene

Previous GeneCards Identifiers for DOCK11 Gene

  • GC0XP116476
  • GC0XP116383
  • GC0XP117411
  • GC0XP117513
  • GC0XP117629
  • GC0XP107125

Summaries for DOCK11 Gene

GeneCards Summary for DOCK11 Gene

DOCK11 (Dedicator Of Cytokinesis 11) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho GTPase binding. An important paralog of this gene is DOCK6.

UniProtKB/Swiss-Prot for DOCK11 Gene

  • Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.

Gene Wiki entry for DOCK11 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK11 Gene

Genomics for DOCK11 Gene

Regulatory Elements for DOCK11 Gene

Promoters for DOCK11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOCK11 on UCSC Golden Path with GeneCards custom track

Genomic Location for DOCK11 Gene

Chromosome:
X
Start:
118,495,898 bp from pter
End:
118,686,163 bp from pter
Size:
190,266 bases
Orientation:
Plus strand

Genomic View for DOCK11 Gene

Genes around DOCK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK11 Gene

Proteins for DOCK11 Gene

  • Protein details for DOCK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSL3-DOC11_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 11
    Protein Accession:
    Q5JSL3
    Secondary Accessions:
    • A6NMF0
    • Q66M66
    • Q6ZUJ5
    • Q86VU8
    • Q96MN3

    Protein attributes for DOCK11 Gene

    Size:
    2073 amino acids
    Molecular mass:
    237671 Da
    Quaternary structure:
    • Interacts with CDC42.
    Miscellaneous:
    • Zizim means spike in Hebrew.
    SequenceCaution:
    • Sequence=BAB71253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86230.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI41407.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41411.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DOCK11 Gene

Proteomics data for DOCK11 Gene at MOPED

Post-translational modifications for DOCK11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOCK11 Gene

No data available for DME Specific Peptides for DOCK11 Gene

Domains & Families for DOCK11 Gene

Gene Families for DOCK11 Gene

Protein Domains for DOCK11 Gene

Suggested Antigen Peptide Sequences for DOCK11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JSL3

UniProtKB/Swiss-Prot:

DOC11_HUMAN :
  • The DHR-2 domain is necessary for the GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain is necessary for the GEF activity.
  • Contains 1 DHR-1 domain.
  • Contains 1 DHR-2 domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK11: view

Function for DOCK11 Gene

Molecular function for DOCK11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP.
genes like me logo Genes that share phenotypes with DOCK11: view

Animal Models for DOCK11 Gene

MGI Knock Outs for DOCK11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK11 Gene

Localization for DOCK11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOCK11 Gene COMPARTMENTS Subcellular localization image for DOCK11 gene
Compartment Confidence
cytosol 5
plasma membrane 3
chloroplast 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DOCK11 Gene

Pathways & Interactions for DOCK11 Gene

genes like me logo Genes that share pathways with DOCK11: view

Pathways by source for DOCK11 Gene

1 BioSystems pathway for DOCK11 Gene
1 GeneGo (Thomson Reuters) pathway for DOCK11 Gene

Interacting Proteins for DOCK11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000276202%0d%0a9606.ENSP00000280333%0d%0a9606.ENSP00000294618%0d%0a9606.ENSP00000365643%0d%0a9606.ENSP00000408464%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q5JSL3-DOC11_HUMAN ENSP00000276202 for DOCK11 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for DOCK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with DOCK11: view

No data available for SIGNOR curated interactions for DOCK11 Gene

Drugs & Compounds for DOCK11 Gene

(1) Drugs for DOCK11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK11: view

Transcripts for DOCK11 Gene

Unigene Clusters for DOCK11 Gene

Dedicator of cytokinesis 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK11 Gene

No ASD Table

Relevant External Links for DOCK11 Gene

GeneLoc Exon Structure for
DOCK11
ECgene alternative splicing isoforms for
DOCK11

Expression for DOCK11 Gene

mRNA expression in normal human tissues for DOCK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOCK11 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for DOCK11 Gene

This gene is overexpressed in Nasal epithelium (21.5), Lavage (20.1), Peripheral blood mononuclear cells (8.3), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOCK11 Gene



SOURCE GeneReport for Unigene cluster for DOCK11 Gene Hs.368203

genes like me logo Genes that share expression patterns with DOCK11: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DOCK11 Gene

Orthologs for DOCK11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOCK11 35
  • 93.41 (n)
  • 97.2 (a)
DOCK11 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOCK11 35
  • 92.84 (n)
  • 97.22 (a)
DOCK11 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dock11 35
  • 91.01 (n)
  • 96.62 (a)
Dock11 16
Dock11 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DOCK11 35
  • 99.54 (n)
  • 99.61 (a)
DOCK11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dock11 35
  • 90.82 (n)
  • 96.33 (a)
oppossum
(Monodelphis domestica)
Mammalia DOCK11 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOCK11 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOCK11 35
  • 76.17 (n)
  • 83.14 (a)
DOCK11 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOCK11 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dock11 35
  • 73.08 (n)
  • 77.51 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC799686 35
  • 64.26 (n)
  • 65.59 (a)
dock11 36
  • 65 (a)
OneToOne
Species with no ortholog for DOCK11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOCK11 Gene

ENSEMBL:
Gene Tree for DOCK11 (if available)
TreeFam:
Gene Tree for DOCK11 (if available)

Paralogs for DOCK11 Gene

Paralogs for DOCK11 Gene

(6) SIMAP similar genes for DOCK11 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DOCK11 Gene

genes like me logo Genes that share paralogs with DOCK11: view

Variants for DOCK11 Gene

Sequence variations from dbSNP and Humsavar for DOCK11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs16995229 - 118,598,081(+) TGAAG(A/T)TTAAA reference, missense
rs929601 -- 118,498,501(-) CTTTG(C/G)TTAAC intron-variant
rs929602 -- 118,498,233(-) TGTGT(C/G)TGGCA intron-variant
rs1287164 -- 118,626,281(+) GGCCA(A/G)GCTGG intron-variant
rs1287165 -- 118,633,638(-) TCAAG(A/G)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK11 Gene

Variant ID Type Subtype PubMed ID
dgv527n21 CNV Gain 19592680
nsv522227 CNV Gain 19592680
nsv510553 CNV Loss 20534489
esv1557323 CNV Insertion 17803354

Variation tolerance for DOCK11 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOCK11 Gene

HapMap Linkage Disequilibrium report
DOCK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK11 Gene

Disorders for DOCK11 Gene

Relevant External Links for DOCK11

Genetic Association Database (GAD)
DOCK11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOCK11

No disorders were found for DOCK11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK11 Gene

Publications for DOCK11 Gene

  1. Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. (PMID: 16968698) Lin Q. … Cerione R.A. (J. Biol. Chem. 2006) 2 3 4 67
  2. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3
  3. Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. (PMID: 25074804) Williamson R.C. … Bass M.D. (J. Cell. Sci. 2014) 3
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
  5. Scanning the human proteome for calmodulin-binding proteins. (PMID: 15840729) Shen X. … Liu R. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3

Products for DOCK11 Gene

Sources for DOCK11 Gene

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