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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOCK11 Gene

protein-coding   GIFtS: 55
GCID: GC0XP117629

dedicator of cytokinesis 11
 Explore 8 diseases affiliated with
DOCK11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DOCK11    

Aliases
for DOCK11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dedicator Of Cytokinesis 111 2     BB128O4.1.1 (Novel Protein)2
ZIZ21 2 3     Dedicator Of Cytokinesis Protein 112
ACG2 3     Zizimin-23
FLJ321221     Zizimin21
FLJ436531     Zizimin-23
Activated Cdc42-Associated Guanine Nucleotide Exchange Factor, ACG2     Activated Cdc42-Associated Guanine Nucleotide Exchange Factor3
BB128O4.11     

External Ids:    HGNC: 234831   Entrez Gene: 1398182   Ensembl: ENSG000001472517   OMIM: 3006815   UniProtKB: Q5JSL33   

Export aliases for DOCK11 gene to outside databases

Previous GC identifers: GC0XP116476 GC0XP116383 GC0XP117411 GC0XP117513 GC0XP107125


Summaries
for DOCK11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DOC11_HUMAN, Q5JSL3
Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By
similarity)

Gene Wiki entry for DOCK11 (Dock11)


Genomic Views
for DOCK11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOCK11 gene promoter:
         Nkx3-1   Nkx3-1 v4   GATA-3   STAT5A   Nkx3-1 v1   Nkx2-5   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK11 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOCK11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

DOCK11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP117629:  view genomic region     (about GC identifiers)

Start:
 117,629,861 bp from pter      End:
 117,820,126 bp from pter
Size:
 190,266 bases      Orientation:
 plus strand

Proteins
for DOCK11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DOC11_HUMAN, Q5JSL3 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 11  
Size: 2073 amino acids; 237671 Da
Subunit: Interacts with CDC42 (By similarity)
Miscellaneous: 'Zizim' means 'spike' in Hebrew
Sequence caution: Sequence=BAB71253.1; Type=Erroneous initiation; Sequence=BAC86230.1; Type=Erroneous initiation;
Sequence=CAI41407.1; Type=Erroneous gene model prediction; Sequence=CAI41411.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NMF0 Q66M66 Q6ZUJ5 Q86VU8 Q96MN3

Explore the universe of human proteins at neXtProt for DOCK11: NX_Q5JSL3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5JSL3

    • DOCK11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_653259.3  
    ENSEMBL proteins: 
     ENSP00000276204   ENSP00000276202  
    Reactome Protein details: Q5JSL3
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate: DOCK11
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    Novus Biologicals DOCK11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DOCK11

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    DOCK11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DOCK11

    Protein Domains /
    Families
    for DOCK11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DOCK11 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR021816 DOCK_C/D_N
     IPR027007 DOCK-C2
     IPR026791 DOCK
     IPR001849 Pleckstrin_homology
     IPR026796 DOCK_D

    Graphical View of Domain Structure for InterPro Entry Q5JSL3

    ProtoNet protein and cluster: Q5JSL3

    1 Blocks protein family: IPB010703 Dedicator of cytokinesis

    UniProtKB/Swiss-Prot: DOC11_HUMAN, Q5JSL3
    Domain: The DHR-2 domain is necessary for the GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 PH domain


    Function
    for DOCK11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DOC11_HUMAN, Q5JSL3
    Function: Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By
    similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK11
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK11:
    hsa-miR-4324 hsa-miR-10b hsa-miR-128 hsa-miR-624* hsa-miR-3681* hsa-miR-10a hsa-miR-544b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmid: DOCK11 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK11 (see all 4)
    OriGene shRNA RFP: DOCK11
    OriGene siRNA: DOCK11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK11

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DOCK11

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK11 (see all 2)
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    Cell Line
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    Search LifeMap BioReagents cell lines for DOCK11

    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005525GTP binding ----
    GO:0005543phospholipid binding IEA--
    GO:0017048Rho GTPase binding IEA--


    DOCK11 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DOCK11:
     Decreased focal adhesion (FA)   Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for DOCK11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling Regulation of RAC1 activity
    		G-protein signaling_Regulation of CDC42 activity0.25
    		G-protein signaling Regulation of CDC42 activity0.25
    2Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    3Regulation of CDC42 activity
    		Regulation of CDC42 activity1.00
    4Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for DOCK11
        G-protein signaling Regulation of CDC42 activity


    1 GeneGo (Thomson Reuters) Pathway for DOCK11
        G-protein signaling Regulation of CDC42 activity

    1 BioSystems Pathway for DOCK11 
        Regulation of CDC42 activity

    2        Reactome Pathways for DOCK11
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    DOCK11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOCK11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for DOCK11 (Q5JSL33 ENSP000002762024) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    ATG4CQ96DT63I2D: score=1 
    CDC42ENSP000003144584STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0007596blood coagulation TAS--


    DOCK11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DOCK11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOCK11

    1 HMDB Compound for DOCK11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about DOCK11 / DOC11 

    Transcripts
    for DOCK11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DOCK11 gene: 
    NM_144658.3  

    Unigene Cluster for DOCK11:

    Dedicator of cytokinesis 11
    Hs.368203  [show with all ESTs]
    Unigene Representative Sequence: NM_144658
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276204(uc004eqp.2 uc004eqq.2) ENST00000276202 ENST00000498252


    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK11:
    hsa-miR-4324 hsa-miR-10b hsa-miR-128 hsa-miR-624* hsa-miR-3681* hsa-miR-10a hsa-miR-544b hsa-miR-378*
    SwitchGear 3'UTR luciferase reporter plasmid: DOCK11 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK11 (see all 4)
    OriGene shRNA RFP: DOCK11
    OriGene siRNA: DOCK11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK11
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK11
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DOCK11 (NM_144658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK11 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DOCK11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK11

    Additional cDNA sequence: 

    AK054649.1 AK056684.1 AK124735.1 AK125641.1 AY692226.1 BC035593.1 BC042053.1 BC047713.1 

    6 DOTS entries:

    DT.309892  DT.100804485  DT.99967465  DT.40240029  DT.95222537  DT.99949504 

    24/93 AceView cDNA sequences (see all 93):

    BU102169 AI742838 AI361832 BC042053 BU101811 AK124735 AW023994 BG545840 
    BM795650 AY692226 AI923047 BU101810 CB270465 NM_144658 BP369093 BC047713 
    AW574560 BX102345 AK054649 AJ705508 CD369436 AK125641 AW515289 BQ879388 

    GeneLoc Exon Structure


    Expression
    for DOCK11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOCK11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTCCAACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DOCK11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    N2/LSB induced-cells (Generation of midbra...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DOCK11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOCK11

    SOURCE GeneReport for Unigene cluster: Hs.368203
        SABiosciences Custom PCR Arrays for DOCK11
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK11

    Orthologs
    for DOCK11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DOCK11 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DOCK111 dedicator of cytokinesis 11 76.17(n)
    83.14(a)    		   422229  XM_003641136.1  XP_003641184.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DOCK116
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343403.1(23172-121161)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7996861 dedicator of cytokinesis 11-like 64.29(n)
    65.64(a)    		   799686  NM_001202493.1  NP_001189422.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG425336
    		 --
    		 35(a)
    		 1 → many
    		 2L(7472513-7496307)
    worm
    (Caenorhabditis elegans)    		 Secernentea F22G12.51 Protein F22G12.5 43.92(n)
    30.7(a)    		   173181  NM_060906.4  NP_493307.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SPK16
    		 guanyl-nucleotide exchange factor / GTPase binding...
    		 21(a)
    		 1 → many
    		 4(9228185-9241317)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 guanine nucleotide exchange factor, putative, expr...
    		 24(a)
    		 1 → many
    		 3(12000006-12006559)


    ENSEMBL Gene Tree for DOCK11 (if available)
    TreeFam Gene Tree for DOCK11 (if available) 

    Paralogs
    for DOCK11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOCK11 gene
    DOCK92  DOCK72  DOCK62  DOCK102  DOCK82  
    8 SIMAP similar genes for DOCK11 using alignment to 3 protein entries:     DOC11_HUMAN (see all proteins):
    DKFZp686N04132    Nbla10300    DRIP2    DOCK9    DOCK10    DKFZp781A1532
    DOCK10.2    DOCK8

    DOCK11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DOCK11
    PGOHUM00000247788


    Genomic Variants
    for DOCK11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2211 NCBI SNPs in DOCK11 are shown (see all 2211)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1399941321,2
    		--117627998(+) ATTGGG/TAGTCT 1 -- us2k10--------
    rs1496665771,2
    		--117628213(+) CAGAGG/TGTATG 1 -- us2k10--------
    rs580817311,2
    		C,--117628223(+) GAATTC/ATTGGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs605468661,2
    		C,--117628278(+) CAAAAC/ATAAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1828217811,2
    		--117628387(+) TACTGA/CGAAGA 1 -- us2k10--------
    rs1136329491,2
    		C,--117628499(+) GTGCCT/CGATGG 1 -- us2k12Minor allele frequency- C:0.00NA CSA 2
    rs1425697811,2
    		C,--117628525(+) CTTTCA/GGAAGG 1 -- us2k10--------
    rs1877763461,2
    		--117628795(+) AGGTGA/GGTGCA 1 -- us2k10--------
    rs735855491,2
    		C,--117629028(+) CCCGTC/GGGGGA 1 -- us2k10--------
    rs16406721,2
    		C,F,A,H,--117629292(-) CCTCCA/GCCCCG 1 -- us2k113Minor allele frequency- G:0.10MN NS EA 2144

    HapMap Linkage Disequilibrium report for DOCK11 (117629861 - 117820126 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for DOCK11
         2 CNVs: 96913 83697
         1 Indel: 83698

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK11
    DNA2.0 Custom Variant and Variant Library Synthesis for DOCK11

    Disorders / Diseases
    for DOCK11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DOCK11 for disorders           About GeneDecksing

    OMIM gene information: 300681    OMIM disorders: --

    8 diseases for DOCK11:    About MalaCards
    angle-closure glaucoma    neuronal ceroid-lipofuscinosis    ceroid lipofuscinosis    atelosteogenesis
    achondrogenesis    glaucoma    gastritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DOCK11:
    Neuronal ceroid lipofuscinosis

    Export disorders for DOCK11 gene to outside databases

    Publications
    for DOCK11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOCK11 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with DOCK11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. (PubMed id 16968698)1, 2 Lin Q.... Cerione R.A. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 3 Cote J.-F. and Vuori K. (2002)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)2 Matsuoka S.... Elledge S.J. (2007)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

    External Searches for DOCK11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing DOCK11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 139818 HGNC: 23483 AceView: DOCK11 Ensembl:ENSG00000147251 euGenes: HUgn139818
    ECgene: DOCK11 H-InvDB: DOCK11

    Other Databases showing DOCK11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DOCK11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOCK11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DOCK11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DOCK11 gene:
    Search GeneIP for patents involving DOCK11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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