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Aliases for DOCK11 Gene

Aliases for DOCK11 Gene

  • Dedicator Of Cytokinesis 11 2 3 5
  • Zizimin-2 3 4
  • Zizimin2 2 3
  • ZIZ2 3 4
  • ACG 3 4
  • Activated Cdc42-Associated Guanine Nucleotide Exchange Factor, ACG 3
  • Activated Cdc42-Associated Guanine Nucleotide Exchange Factor 4
  • Dedicator Of Cytokinesis Protein 11 3
  • BB128O4.1.1 (Novel Protein) 3
  • BB128O4.1 3

External Ids for DOCK11 Gene

Previous GeneCards Identifiers for DOCK11 Gene

  • GC0XP116476
  • GC0XP116383
  • GC0XP117411
  • GC0XP117513
  • GC0XP117629
  • GC0XP107125

Summaries for DOCK11 Gene

GeneCards Summary for DOCK11 Gene

DOCK11 (Dedicator Of Cytokinesis 11) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and Regulation of CDC42 activity. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho GTPase binding. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot for DOCK11 Gene

  • Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.

Gene Wiki entry for DOCK11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK11 Gene

Genomics for DOCK11 Gene

Regulatory Elements for DOCK11 Gene

Enhancers for DOCK11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG118519 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.2 +26.6 26561 6.0 HDAC1 PKNOX1 ARNT ZNF133 ZBTB40 TCF12 ELK1 GATA2 EGR1 FOS DOCK11 LONRF3 WDR44 GC0XM118570 ENSG00000206862
GH0XG118527 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.9 +33.4 33449 4.4 TBP PKNOX1 ZNF146 CEBPG ZBTB40 IRF9 EGR1 ZBTB48 POLR2A EED LONRF3 DOCK11 IL13RA1 ENSG00000206862 GC0XM118570
GH0XG118535 1.3 Ensembl ENCODE dbSUPER 14 +41.6 41637 4.0 CTCF ZNF792 ETV1 FEZF1 RAD21 YY1 ARID3A ZBTB48 ZSCAN5C ZNF143 DOCK11 ENSG00000206862 GC0XM118570
GH0XG118525 0.8 Ensembl dbSUPER 17.8 +30.3 30303 1.2 OSR2 PRDM6 PBX2 ZNF341 WT1 TRIM28 DOCK11 ENSG00000206862 GC0XM118570
GH0XG118723 1.7 FANTOM5 Ensembl ENCODE 7.3 +231.6 231577 7.9 PKNOX1 FOXA2 ARID4B SIN3A YY1 FOS KLF13 SP3 SP5 JUNB IL13RA1 LONRF3 DOCK11 ZCCHC12 ENSG00000239182
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOCK11 on UCSC Golden Path with GeneCards custom track

Promoters for DOCK11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248259 602 2601 HDGF SIN3A GLIS2 KLF7 KLF13 ZNF263 SP3 REST ZNF579 GLIS1

Genomic Location for DOCK11 Gene

Chromosome:
X
Start:
118,495,898 bp from pter
End:
118,686,163 bp from pter
Size:
190,266 bases
Orientation:
Plus strand

Genomic View for DOCK11 Gene

Genes around DOCK11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK11 Gene

Proteins for DOCK11 Gene

  • Protein details for DOCK11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSL3-DOC11_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 11
    Protein Accession:
    Q5JSL3
    Secondary Accessions:
    • A6NMF0
    • Q66M66
    • Q6ZUJ5
    • Q86VU8
    • Q96MN3

    Protein attributes for DOCK11 Gene

    Size:
    2073 amino acids
    Molecular mass:
    237671 Da
    Quaternary structure:
    • Interacts with CDC42.
    Miscellaneous:
    • Zizim means spike in Hebrew.
    SequenceCaution:
    • Sequence=BAB71253.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC86230.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI41407.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41411.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DOCK11 Gene

Post-translational modifications for DOCK11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOCK11 Gene

No data available for DME Specific Peptides for DOCK11 Gene

Domains & Families for DOCK11 Gene

Gene Families for DOCK11 Gene

Suggested Antigen Peptide Sequences for DOCK11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JSL3

UniProtKB/Swiss-Prot:

DOC11_HUMAN :
  • The DHR-2 domain is necessary for the GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain is necessary for the GEF activity.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK11: view

Function for DOCK11 Gene

Molecular function for DOCK11 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42.

Gene Ontology (GO) - Molecular Function for DOCK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA,ISS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 25074804
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DOCK11: view
genes like me logo Genes that share phenotypes with DOCK11: view

Animal Models for DOCK11 Gene

MGI Knock Outs for DOCK11:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK11 Gene

Localization for DOCK11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK11 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for DOCK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DOCK11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOCK11 Gene

Pathways & Interactions for DOCK11 Gene

genes like me logo Genes that share pathways with DOCK11: view

Pathways by source for DOCK11 Gene

1 BioSystems pathway for DOCK11 Gene
1 GeneGo (Thomson Reuters) pathway for DOCK11 Gene

Interacting Proteins for DOCK11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000276202%0d%0a9606.ENSP00000364582%0d%0a9606.ENSP00000314458%0d%0a9606.ENSP00000293373%0d%0a9606.ENSP00000354251%0d%0a9606.ENSP00000320176%0d%0a
Selected Interacting proteins: ENSP00000276202 Q5JSL3-DOC11_HUMAN for DOCK11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DOCK11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0002315 marginal zone B cell differentiation IEA,ISS --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0043547 positive regulation of GTPase activity IEA,ISS --
genes like me logo Genes that share ontologies with DOCK11: view

No data available for SIGNOR curated interactions for DOCK11 Gene

Drugs & Compounds for DOCK11 Gene

(1) Drugs for DOCK11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK11: view

Transcripts for DOCK11 Gene

Unigene Clusters for DOCK11 Gene

Dedicator of cytokinesis 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK11 Gene

No ASD Table

Relevant External Links for DOCK11 Gene

GeneLoc Exon Structure for
DOCK11
ECgene alternative splicing isoforms for
DOCK11

Expression for DOCK11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOCK11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOCK11 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for DOCK11 Gene

This gene is overexpressed in Nasal epithelium (21.5), Lavage (20.1), Peripheral blood mononuclear cells (8.3), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOCK11 Gene



NURSA nuclear receptor signaling pathways regulating expression of DOCK11 Gene:

DOCK11

SOURCE GeneReport for Unigene cluster for DOCK11 Gene:

Hs.368203

Evidence on tissue expression from TISSUES for DOCK11 Gene

  • Nervous system(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with DOCK11: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK11 Gene

Orthologs for DOCK11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOCK11 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia DOCK11 34 35
  • 93.41 (n)
dog
(Canis familiaris)
Mammalia DOCK11 34 35
  • 92.84 (n)
mouse
(Mus musculus)
Mammalia Dock11 34 16 35
  • 91.01 (n)
rat
(Rattus norvegicus)
Mammalia Dock11 34
  • 90.82 (n)
oppossum
(Monodelphis domestica)
Mammalia DOCK11 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOCK11 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOCK11 34 35
  • 76.17 (n)
lizard
(Anolis carolinensis)
Reptilia DOCK11 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dock11 34
  • 73.08 (n)
zebrafish
(Danio rerio)
Actinopterygii dock11 35
  • 65 (a)
OneToOne
LOC799686 34
  • 64.26 (n)
Species where no ortholog for DOCK11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOCK11 Gene

ENSEMBL:
Gene Tree for DOCK11 (if available)
TreeFam:
Gene Tree for DOCK11 (if available)

Paralogs for DOCK11 Gene

Paralogs for DOCK11 Gene

(6) SIMAP similar genes for DOCK11 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DOCK11 Gene

genes like me logo Genes that share paralogs with DOCK11: view

Variants for DOCK11 Gene

Sequence variations from dbSNP and Humsavar for DOCK11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000001374 -- 118,513,305(+) TGATG(G/T)CTGGA intron-variant
rs1000008050 -- 118,526,009(+) CTTAA(G/T)TCACA intron-variant
rs1000058548 -- 118,645,350(+) TGAAG(C/T)GTTCA intron-variant
rs1000061380 -- 118,668,940(+) ATAAC(A/G)TAAAG intron-variant
rs1000113199 -- 118,586,357(+) TCGTG(G/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK11 Gene

Variant ID Type Subtype PubMed ID
dgv527n21 CNV gain 19592680
esv1557323 CNV insertion 17803354
nsv510553 OTHER sequence alteration 20534489
nsv522227 CNV gain 19592680

Variation tolerance for DOCK11 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOCK11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK11 Gene

Disorders for DOCK11 Gene

Relevant External Links for DOCK11

Genetic Association Database (GAD)
DOCK11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOCK11

No disorders were found for DOCK11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK11 Gene

Publications for DOCK11 Gene

  1. Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42. (PMID: 16968698) Lin Q. … Cerione R.A. (J. Biol. Chem. 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3 64
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for DOCK11 Gene

Sources for DOCK11 Gene

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