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Aliases for DOCK10 Gene

Aliases for DOCK10 Gene

  • Dedicator Of Cytokinesis 10 2 3
  • ZIZ3 3 4 6
  • Zizimin3 2 3
  • KIAA0694 4 6
  • Dopamine Receptor Interacting Protein 2 3
  • Dedicator Of Cytokinesis Protein 10 3
  • Nbla10300 3
  • Zizimin-3 4
  • DRIP2 3

External Ids for DOCK10 Gene

Previous GeneCards Identifiers for DOCK10 Gene

  • GC02M225593
  • GC02M225832
  • GC02M225455
  • GC02M225338
  • GC02M217481

Summaries for DOCK10 Gene

Entrez Gene Summary for DOCK10 Gene

  • This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for DOCK10 Gene

DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Hemostasis and Regulation of CDC42 activity. GO annotations related to this gene include phospholipid binding and Rho GTPase binding. An important paralog of this gene is DOCK6.

UniProtKB/Swiss-Prot for DOCK10 Gene

  • Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP

Gene Wiki entry for DOCK10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK10 Gene

Genomics for DOCK10 Gene

Regulatory Elements for DOCK10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOCK10 Gene

224,765,090 bp from pter
225,042,613 bp from pter
277,524 bases
Minus strand

Genomic View for DOCK10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOCK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK10 Gene

Proteins for DOCK10 Gene

  • Protein details for DOCK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dedicator of cytokinesis protein 10
    Protein Accession:
    Secondary Accessions:
    • B3FL70
    • O75178
    • Q9NW06
    • Q9NXI8

    Protein attributes for DOCK10 Gene

    2186 amino acids
    Molecular mass:
    249531 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91022.1; Type=Frameshift; Positions=2133; Evidence={ECO:0000305}; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DOCK10 Gene


neXtProt entry for DOCK10 Gene

Proteomics data for DOCK10 Gene at MOPED

Post-translational modifications for DOCK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOCK10 Gene

No data available for DME Specific Peptides for DOCK10 Gene

Domains for DOCK10 Gene

Gene Families for DOCK10 Gene

  • PLEKH :Pleckstrin homology (PH) domain containing

Protein Domains for DOCK10 Gene

Suggested Antigen Peptide Sequences for DOCK10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96BY6
  • The DHR-2 domain may mediate some GEF activity.
  • Contains 1 DHR-1 domain.
  • Contains 1 DHR-2 domain.
  • Contains 1 PH domain.
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK10: view

Function for DOCK10 Gene

Molecular function for DOCK10 Gene

UniProtKB/Swiss-Prot Function:
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP
UniProtKB/Swiss-Prot Induction:
Isoforms 1 and 2 are up-regulated in response to interleukin-4.

Gene Ontology (GO) - Molecular Function for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005085 guanyl-nucleotide exchange factor activity --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DOCK10: view

Phenotypes for DOCK10 Gene

GenomeRNAi human phenotypes for DOCK10:
genes like me logo Genes that share phenotypes with DOCK10: view

Animal Model Products

miRNA for DOCK10 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DOCK10 Gene

Localization for DOCK10 Gene

Subcellular locations from

Jensen Localization Image for DOCK10 Gene COMPARTMENTS Subcellular localization image for DOCK10 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DOCK10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOCK10 Gene

Pathways for DOCK10 Gene

genes like me logo Genes that share pathways with DOCK10: view

Pathways by source for DOCK10 Gene

1 BioSystems pathway for DOCK10 Gene

Gene Ontology (GO) - Biological Process for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030334 regulation of cell migration IDA 18835169
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DOCK10: view

Compounds for DOCK10 Gene

(3) HMDB Compounds for DOCK10 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with DOCK10: view

Transcripts for DOCK10 Gene

mRNA/cDNA for DOCK10 Gene

(14) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOCK10 Gene

Dedicator of cytokinesis 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOCK10

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -

Relevant External Links for DOCK10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOCK10 Gene

mRNA expression in normal human tissues for DOCK10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOCK10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.6).

Protein differential expression in normal tissues for DOCK10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lymph node (15.8), CD8 Tcells (6.9), and Pancreas (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOCK10 Gene

SOURCE GeneReport for Unigene cluster for DOCK10 Gene Hs.46578

mRNA Expression by UniProt/SwissProt for DOCK10 Gene

Tissue specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
genes like me logo Genes that share expressions with DOCK10: view

In Situ Assay Products

No data available for Expression partners for DOCK10 Gene

Orthologs for DOCK10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DOCK10 35
  • 90.88 (n)
  • 94.73 (a)
DOCK10 36
  • 92 (a)
(Canis familiaris)
Mammalia DOCK10 35
  • 91.73 (n)
  • 95.76 (a)
DOCK10 36
  • 94 (a)
(Mus musculus)
Mammalia Dock10 35
  • 87.44 (n)
  • 93.78 (a)
Dock10 16
Dock10 36
  • 94 (a)
(Pan troglodytes)
Mammalia DOCK10 35
  • 99.53 (n)
  • 99.73 (a)
DOCK10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dock10 35
  • 87.41 (n)
  • 93.3 (a)
(Monodelphis domestica)
Mammalia DOCK10 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
-- 36
  • 73 (a)
-- 36
  • 84 (a)
(Gallus gallus)
Aves DOCK10 35
  • 78.37 (n)
  • 82.75 (a)
DOCK10 36
  • 83 (a)
(Anolis carolinensis)
Reptilia DOCK10 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dock10 35
  • 71.93 (n)
  • 74.5 (a)
(Danio rerio)
Actinopterygii dock10 35
  • 67.16 (n)
  • 69.77 (a)
dock10 36
  • 67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
Species with no ortholog for DOCK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOCK10 Gene

Gene Tree for DOCK10 (if available)
Gene Tree for DOCK10 (if available)

Paralogs for DOCK10 Gene

Paralogs for DOCK10 Gene

Selected SIMAP similar genes for DOCK10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DOCK10: view

Variants for DOCK10 Gene

Sequence variations from dbSNP and Humsavar for DOCK10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs51071 -- 225,028,795(-) CAGTT(A/G)AAAAT intron-variant
rs166842 -- 225,017,569(-) AGAAG(C/G)ATGTA intron-variant
rs182215 -- 225,006,942(-) CAGTT(A/G)GGTGA intron-variant
rs185797 -- 225,031,274(+) CCATA(C/T)TGTAT intron-variant
rs188140 -- 225,033,331(+) GTGCA(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK10 Gene

Variant ID Type Subtype PubMed ID
nsv875909 CNV Gain 21882294
nsv470519 CNV Gain 18288195
nsv875912 CNV Gain 21882294
nsv3185 CNV Loss 18451855
esv2663234 CNV Deletion 23128226
esv2668530 CNV Deletion 23128226
esv274230 CNV Insertion 20981092
esv268262 CNV Insertion 20981092
esv8487 CNV Gain 19470904
esv1011163 CNV Insertion 20482838
nsv508131 CNV Loss 20534489
esv1010048 CNV Insertion 20482838
esv2721534 CNV Deletion 23290073
esv4249 CNV Deletion 18987735
esv2721535 CNV Deletion 23290073
esv1631002 CNV Deletion 17803354
dgv674e201 CNV Deletion 23290073
nsv517969 CNV Loss 19592680

Relevant External Links for DOCK10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK10 Gene

Disorders for DOCK10 Gene

Relevant External Links for DOCK10

Genetic Association Database (GAD)

No disorders were found for DOCK10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DOCK10 Gene

Publications for DOCK10 Gene

  1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3 4
  2. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E. … Parrado A. (Mol. Immunol. 2008) 3 23
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DOCK10 Gene

Sources for DOCK10 Gene

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