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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DOCK10 Gene

protein-coding GIFtS: 56
GCID: GC02M225593

Dedicator Of Cytokinesis 10

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 10¹ ²		Dedicator Of Cytokinesis Protein 10²
ZIZ3² ³ ⁵		Dopamine Receptor Interacting Protein 2²
zizimin3¹ ²		Protein Zizimin 3²
KIAA0694³ ⁵		zizimin-3²
DRIP2²		Zizimin-3³
Nbla10300²

External Ids:	HGNC: 23479¹	Entrez Gene: 55619²	Ensembl: ENSG00000135905⁷	OMIM: 611518⁵	UniProtKB: Q96BY6³

Export aliases for DOCK10 gene to outside databases

Previous GC identifers: GC02M225832 GC02M225455 GC02M225338 GC02M217481

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DOCK10 Gene:

DOCK10 (dedicator of cytokinesis 10) is a protein-coding gene. Diseases associated with DOCK10 include melanoma, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include Rho GTPase binding and phospholipid binding. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging

bound GDP for free GTP

Gene Wiki entry for DOCK10 (Dock10) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NT_005403.17 NC_018913.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DOCK10 gene promoter:
STAT1 Elk-1 STAT1beta STAT6 CUTL1 STAT1alpha CREB STAT2 deltaCREB STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK10 promoter sequence

Search SABiosciences Chromatin IP Primers for DOCK10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.2 Ensembl cytogenetic band: 2q36.2 HGNC cytogenetic band: 2q36.3

DOCK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK10 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M225593: view genomic region (about GC identifiers)

Start:	225,629,807 bp from pter	End:	225,907,330 bp from pter
Size:	277,524 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6 (See protein sequence)

Recommended Name: Dedicator of cytokinesis protein 10

Size: 2186 amino acids; 249531 Da

Sequence caution: Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA91022.1;

Type=Frameshift; Positions=2133; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

Secondary accessions: O75178 Q9NW06 Q9NXI8

Alternative splicing: 2 isoforms: Q96BY6-1 Q96BY6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK10: NX_Q96BY6

Explore proteomics data for DOCK10 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96BY6

DOCK10 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_055504.2

ENSEMBL proteins:

ENSP00000386694 ENSP00000258390 ENSP00000437947 ENSP00000395178 ENSP00000394552

ENSP00000397389

Reactome Protein details: Q96BY6
Human Recombinant Protein Products for DOCK10:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

PLEKH: Pleckstrin homology (PH) domain containing

5/8 InterPro protein domains (see all 8):

IPR021816 DOCK_C/D_N

IPR027007 DHR-1_domain

IPR026791 DOCK

IPR001849 Pleckstrin_homology

IPR026796 DOCK_D

Graphical View of Domain Structure for InterPro Entry Q96BY6

ProtoNet protein and cluster: Q96BY6

2 Blocks protein domains:

IPB001849 Pleckstrin-like

IPB010703 Dedicator of cytokinesis

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Domain: The DHR-2 domain may mediate some GEF activity (By similarity)

Similarity: Belongs to the DOCK family

Similarity: Contains 1 DHR-1 domain

Similarity: Contains 1 DHR-2 domain

Similarity: Contains 1 PH domain

DOCK10 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DOC10_HUMAN, Q96BY6

Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging

bound GDP for free GTP

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	--	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005488	binding	--	--
GO:0005515	protein binding	--	--
GO:0005543	phospholipid binding	IEA	--

DOCK10 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DOCK10:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for DOCK10

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DOCK10

miRNA Products:
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK10:
		hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for DOCK10 About

See pathways by source

SuperPath

Contained pathways About

Platelet activation, signaling and aggregation

Hemostasis

0.43

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

Regulation of CDC42 activity

Regulation of CDC42 activity

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for DOCK10

Regulation of CDC42 activity

2 Reactome Pathways for DOCK10

	Hemostasis
	Factors involved in megakaryocyte development and platelet production

DOCK10 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DOCK10

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for DOCK10 (Q96BY6³ ENSP00000258390⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHOJ	Q9H4E5³, ENSP00000316729⁴	I2D: score=1 STRING: ENSP00000316729
LURAP1	Q96LR2³, ENSP00000361048⁴	I2D: score=3 STRING: ENSP00000361048
CDC42	ENSP00000314458⁴	STRING: ENSP00000314458

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--

DOCK10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DOCK10 (DOC10)

3 HMDB Compounds for DOCK10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about DOCK10 / DOC10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DOCK10 gene (2 alternative transcripts):

NM_017718.1 NM_014689.2

Unigene Cluster for DOCK10:

Dedicator of cytokinesis 10

Hs.46578 [show with all ESTs]

Unigene Representative Sequence: NM_014689

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409592(uc002vob.2) ENST00000258390(uc002voa.2 uc002voc.2 uc010fwz.1)

ENST00000535663 ENST00000492251 ENST00000422684 ENST00000489831 ENST00000472652

ENST00000492369(uc002vod.1) ENST00000543715 ENST00000471810 ENST00000474102

ENST00000435582 ENST00000458608

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK10
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK10:
		hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against DOCK10

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK10

Additional mRNA sequence:

AB014594.2 AB074179.1 AF250396.1 AK000227.1 AK001253.1 AK130257.1 AK293847.1 AK293879.1

AK307914.1 BC015018.1 CR749492.1 EU236710.2

13 DOTS entries:

DT.313890 DT.101978788 DT.91723314 DT.92035575 DT.100010125 DT.120985656 DT.120985681 DT.91981816

DT.120942277 DT.100717776 DT.40130726 DT.95368908 DT.95368909

1 AceView cDNA sequence:

BX493605

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22
SP1:																									-
SP2:																																											-
SP3:

ECgene alternative splicing isoforms for DOCK10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DOCK10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAATTCCAGT

About this image

See DOCK10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOCK10

SOURCE GeneReport for Unigene cluster: Hs.46578

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Tissue specificity: Expressed at low level in brain and lung

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DOCK10 gene from 6/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dock10^{1 , 5}	dedicator of cytokinesis 10^{1, 5}	87.44(n)¹ 93.78(a)¹		1 (41.41 cM)⁵ 210293¹ NM_175291.3¹ NP_780500.2¹ 80501073⁵
chicken (Gallus gallus)	Aves	DOCK10¹	dedicator of cytokinesis 10	78.43(n) 82.88(a)		424803 XM_001234659.2 XP_001234660.2
lizard (Anolis carolinensis)	Reptilia	DOCK10⁶	Uncharacterized protein	81(a)	1 ↔ 1	3(24454172-24644014)
zebrafish (Danio rerio)	Actinopterygii	dock10¹	dedicator of cytokinesis 10	67.36(n) 70.24(a)		100000949 XM_001341012.4 XP_001341048.4
fruit fly (Drosophila melanogaster)	Insecta	CG42533⁶	--	34(a)	1 → many	2L(7472513-7496307)
worm (Caenorhabditis elegans)	Secernentea	F22G12.5⁶	Protein F22G12.5, isoform b	21(a)	1 → many	I(13162499-13182808)

ENSEMBL Gene Tree for DOCK10 (if available)
TreeFam Gene Tree for DOCK10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DOCK10 gene

DOCK9² DOCK7² DOCK11² DOCK6² DOCK8²

10 SIMAP similar genes for DOCK10 using alignment to 6 protein entries: DOC10_HUMAN (see all proteins):

DOCK10.2 Nbla10300 DKFZp781A1532 DRIP2 DKFZp686N04132 DOCK11

DOCK9 DOCK7 DOCK6 DOCK8

DOCK10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5839080^1,2	C	--	225173173(+)	`AAAAA-/ACTCTT`	1	--	int¹ trp³		0	--	--	--	--
rs193161011^1,2		--	225629307(+)	`GTACTA/GAGGCT`	1	--	ds500¹		0	--	--	--	--
rs7557657^1,2	C,A	--	225629474(+)	`gtcacA/Gtggtc`	1	--	ds500¹		1		NA	2
rs7584202^1,2	A	--	225629507(+)	`ggaaaC/Gtgcaa`	1	--	ds500¹		0	--	--	--	--
rs184351306^1,2		--	225629576(+)	`ACAGAC/TCTCAA`	1	--	ds500¹		0	--	--	--	--
rs74333489^1,2	C	--	225629643(+)	`ACCTCT/CGATCT`	1	--	ds500¹		2		CSA WA	120
rs76185447^1,2	F	--	225629687(+)	`AGATTT/AGAGTC`	1	--	ds500¹		1		EA	120
rs17271491^1,2	C,F	--	225629713(+)	`GGCAAG/AGCATC`	1	--	ds500¹		6		NA	266
rs74548362^1,2	F	--	225629788(+)	`CCCACT/GCTTCA`	1	--	ds500¹		1		WA	118
rs144192577^1,2	C	--	225630149(+)	`TGGGGC/TACTGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DOCK10 (225629807 - 225879807 bp, first 250kb of DOCK10)

Structural Variations
Database of Genomic Variants (DGV) 10/18 variations for DOCK10 (see all 18): About this table

Variant ID	Type	Subtype	PubMed ID
esv2721534	CNV	Deletion	23290073
esv1631002	CNV	Deletion	17803354
esv2668530	CNV	Deletion	23128226
esv2663234	CNV	Deletion	23128226
esv2721535	CNV	Deletion	23290073
esv4249	CNV	Deletion	18987735
dgv674e201	CNV	Deletion	23290073
esv268262	CNV	Insertion	20981092
esv274230	CNV	Insertion	20981092
esv1010048	CNV	Insertion	20482838

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK10

DNA2.0 Custom Variant and Variant Library Synthesis for DOCK10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DOCK10 for disorders           About GeneDecksing

OMIM gene information: 611518    OMIM disorders: --

2 diseases for DOCK10:    About MalaCards

melanoma

Genetic Association Database (GAD): DOCK10

Export disorders for DOCK10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DOCK10 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with DOCK10)

Utopia: connect your pdf to the dynamic
world of online information

Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)^{1, 2, 3} Cote J.-F. and Vuori K. (2002)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (1998)
Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PubMed id 18499258)^{1, 9} Yelo E....Parrado A. (2008)
Human and mouse DOCK10 splicing isoforms with alterna tive first coding exon usage are differentially expressed in T and B lymphocyte s. (PubMed id 21514340)¹ Alcaraz-GarcA-a M.J....Parrado A. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55619	HGNC: 23479	AceView: DOCK10.2	Ensembl:ENSG00000135905	euGenes: HUgn55619
ECgene: DOCK10	H-InvDB: DOCK10

(According to HUGE)
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HUGE: KIAA0694

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DOCK10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DOCK10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DOCK10 gene:
Search GeneIP for patents involving DOCK10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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Dedicator Of Cytokinesis 10

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DOCK10 Gene

Dedicator Of Cytokinesis 10

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