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DOCK10 Gene(Protein Coding)

Dedicator Of Cytokinesis 10

GCID:
GC02M224765
GIFtS:
54
Genes Participants
UDN Logo

Aliases for DOCK10 Gene

Aliases for DOCK10 Gene

  • Dedicator Of Cytokinesis 10 2 3 5
  • Zizimin3 2 3
  • ZIZ3 3 4
  • Dopamine Receptor Interacting Protein 2 3
  • Nbla10300 3
  • Zizimin-3 4
  • KIAA0694 4
  • DRIP2 3

External Ids for DOCK10 Gene

Previous GeneCards Identifiers for DOCK10 Gene

  • GC02M225593
  • GC02M225832
  • GC02M225455
  • GC02M225338
  • GC02M217481

Summaries for DOCK10 Gene

Entrez Gene Summary for DOCK10 Gene

  • This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for DOCK10 Gene

DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Regulation of CDC42 activity. GO annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK6.

UniProtKB/Swiss-Prot for DOCK10 Gene

  • Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.

Gene Wiki entry for DOCK10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK10 Gene

Genomics for DOCK10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DOCK10 Gene

Enhancers for DOCK10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DOCK10 on UCSC Golden Path with GeneCards custom track

Promoters for DOCK10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DOCK10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DOCK10 gene promoter:

Genomic Location for DOCK10 Gene

Chromosome:
2
Start:
224,765,090 bp from pter
End:
225,042,613 bp from pter
Size:
277,524 bases
Orientation:
Minus strand

Genomic View for DOCK10 Gene

Genes around DOCK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DOCK10 Gene

Proteins for DOCK10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DOCK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BY6-DOC10_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 10
    Protein Accession:
    Q96BY6
    Secondary Accessions:
    • B3FL70
    • O75178
    • Q9NW06
    • Q9NXI8

    Protein attributes for DOCK10 Gene

    Size:
    2186 amino acids
    Molecular mass:
    249531 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91022.1; Type=Frameshift; Positions=2133; Evidence={ECO:0000305}; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DOCK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOCK10 Gene

Proteomics data for DOCK10 Gene at MOPED

Protein Expression for DOCK10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DOCK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOCK10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DOCK10 Gene

Domains & Families for DOCK10 Gene

Gene Families for DOCK10 Gene

HGNC:

Protein Domains for DOCK10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DOCK10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BY6

UniProtKB/Swiss-Prot:

DOC10_HUMAN :
  • The DHR-2 domain may mediate some GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain may mediate some GEF activity.
  • Contains 1 DHR-1 domain.
  • Contains 1 DHR-2 domain.
  • Contains 1 PH domain.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK10: view

Function for DOCK10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DOCK10 Gene

UniProtKB/Swiss-Prot Function:
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.
UniProtKB/Swiss-Prot Induction:
Isoforms 1 and 2 are up-regulated in response to interleukin-4.

Gene Ontology (GO) - Molecular Function for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DOCK10: view

Phenotypes for DOCK10 Gene

GenomeRNAi human phenotypes for DOCK10:
genes like me logo Genes that share phenotypes with DOCK10: view

Animal Model Products

miRNA for DOCK10 Gene

miRTarBase miRNAs that target DOCK10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOCK10 Gene

Localization for DOCK10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOCK10 Gene COMPARTMENTS Subcellular localization image for DOCK10 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DOCK10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DOCK10 Gene

Pathways & Interactions for DOCK10 Gene

genes like me logo Genes that share pathways with DOCK10: view

Pathways by source for DOCK10 Gene

1 BioSystems pathway for DOCK10 Gene

Gene Ontology (GO) - Biological Process for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with DOCK10: view

No data available for SIGNOR curated interactions for DOCK10 Gene

Drugs & Compounds for DOCK10 Gene

Products:

  1. Drug

(3) Drugs for DOCK10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK10: view

Transcripts for DOCK10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DOCK10 Gene

(14) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOCK10 Gene

Dedicator of cytokinesis 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:

Relevant External Links for DOCK10 Gene

GeneLoc Exon Structure for
DOCK10
ECgene alternative splicing isoforms for
DOCK10

Expression for DOCK10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for DOCK10 Gene

mRNA expression in normal human tissues for DOCK10 Gene
mRNA expression by BioGPS for DOCK10 GenemRNA expression by GTEx for DOCK10 Gene

mRNA differential expression in normal tissues according to GTEx for DOCK10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for DOCK10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lymph node (15.8), CD8 Tcells (6.9), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOCK10 Gene



SOURCE GeneReport for Unigene cluster for DOCK10 Gene Hs.46578

mRNA Expression by UniProt/SwissProt for DOCK10 Gene

Q96BY6-DOC10_HUMAN
Tissue specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
genes like me logo Genes that share expression patterns with DOCK10: view

Primer Products

No data available for Protein tissue co-expression partners for DOCK10 Gene

Orthologs for DOCK10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia DOCK10 35
  • 90.88 (n)
  • 94.73 (a)
DOCK10 36
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia DOCK10 35
  • 91.73 (n)
  • 95.76 (a)
DOCK10 36
  • 94 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dock10 35
  • 87.44 (n)
  • 93.78 (a)
Dock10 16
Dock10 36
  • 94 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia DOCK10 35
  • 99.53 (n)
  • 99.73 (a)
DOCK10 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Dock10 35
  • 87.41 (n)
  • 93.3 (a)
oppossum
(Monodelphis domestica)
 Mammalia DOCK10 36
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 78 (a)
 OneToMany
-- 36
  • 73 (a)
 OneToMany
-- 36
  • 84 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves DOCK10 35
  • 78.37 (n)
  • 82.75 (a)
DOCK10 36
  • 83 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DOCK10 36
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dock10 35
  • 71.93 (n)
  • 74.5 (a)
zebrafish
(Danio rerio)
 Actinopterygii dock10 35
  • 67.16 (n)
  • 69.77 (a)
dock10 36
  • 67 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 59 (a)
 OneToOne
Species with no ortholog for DOCK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOCK10 Gene

ENSEMBL:
Gene Tree for DOCK10 (if available)
TreeFam:
Gene Tree for DOCK10 (if available)

Paralogs for DOCK10 Gene

Paralogs for DOCK10 Gene

(9) SIMAP similar genes for DOCK10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DOCK10: view

Variants for DOCK10 Gene

Sequence variations from dbSNP and Humsavar for DOCK10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs367427 -- 225,037,054(+) AATGG(A/T)AATAC intron-variant
rs375154 -- 225,015,357(+) GATTT(C/T)ACCAT intron-variant
rs375205 -- 224,983,862(+) CTAAC(C/T)CCCTC intron-variant, upstream-variant-2KB
rs377571 -- 224,986,188(+) GGAAA(A/C)CTACT intron-variant
rs379579 -- 225,039,338(+) TTGAC(A/T)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK10 Gene

Variant ID Type Subtype PubMed ID
nsv875909 CNV Gain 21882294
nsv470519 CNV Gain 18288195
nsv875912 CNV Gain 21882294
nsv3185 CNV Loss 18451855
esv2663234 CNV Deletion 23128226
esv2668530 CNV Deletion 23128226
esv274230 CNV Insertion 20981092
esv268262 CNV Insertion 20981092
esv8487 CNV Gain 19470904
esv1011163 CNV Insertion 20482838
nsv508131 CNV Loss 20534489
esv1010048 CNV Insertion 20482838
esv2721534 CNV Deletion 23290073
esv4249 CNV Deletion 18987735
esv2721535 CNV Deletion 23290073
esv1631002 CNV Deletion 17803354
dgv674e201 CNV Deletion 23290073
nsv517969 CNV Loss 19592680

Variation tolerance for DOCK10 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.65; 91.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DOCK10 Gene

Disorders for DOCK10 Gene

Relevant External Links for DOCK10

Genetic Association Database (GAD)
DOCK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOCK10

No disorders were found for DOCK10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK10 Gene

Publications for DOCK10 Gene

  1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3 4 67
  2. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E. … Parrado A. (Mol. Immunol. 2008) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PMID: 23967269) Kim J.H. … Shin H.D. (PLoS ONE 2013) 3
  5. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PMID: 21514340) Alcaraz-Garcia M.J. … Parrado A. (Hum. Immunol. 2011) 3

Products for DOCK10 Gene

Sources for DOCK10 Gene

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