Aliases for DOCK10 Gene
External Ids for DOCK10 Gene
Previous GeneCards Identifiers for DOCK10 Gene
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
GeneCards Summary for DOCK10 Gene
DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Regulation of CDC42 activity and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.
UniProtKB/Swiss-Prot for DOCK10 Gene
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pahtway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.