Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DOCK10 Gene

protein-coding GIFtS: 56
GCID: GC02M225593

dedicator of cytokinesis 10

Explore 1 disease affiliated with
DOCK10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 10¹ ²		Dopamine Receptor Interacting Protein 2²
ZIZ3¹ ² ³ ⁵		Protein Zizimin 3²
KIAA0694¹ ³ ⁵		Zizimin-3³
DRIP2²		Zizimin3¹
Nbla10300²		Zizimin-3³
Dedicator Of Cytokinesis Protein 10²

External Ids:	HGNC: 23479¹	Entrez Gene: 55619²	Ensembl: ENSG00000135905⁷	OMIM: 611518⁵	UniProtKB: Q96BY6³

Export aliases for DOCK10 gene to outside databases

Previous GC identifers: GC02M225832 GC02M225455 GC02M225338 GC02M217481

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging

bound GDP for free GTP

Gene Wiki entry for DOCK10 (Dock10)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DOCK10 gene promoter:
STAT1 Elk-1 STAT1beta STAT6 CUTL1 STAT1alpha CREB STAT2 deltaCREB STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK10 promoter sequence

Search SABiosciences Chromatin IP Primers for DOCK10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.2 Ensembl cytogenetic band: 2q36.2 HGNC cytogenetic band: 2q36.3

DOCK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK10 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M225593: view genomic region (about GC identifiers)

Start:	225,629,807 bp from pter	End:	225,907,330 bp from pter
Size:	277,524 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6 (See protein sequence)

Recommended Name: Dedicator of cytokinesis protein 10

Size: 2186 amino acids; 249531 Da

Sequence caution: Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA91022.1;

Type=Frameshift; Positions=2133; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

Secondary accessions: O75178 Q9NW06 Q9NXI8

Alternative splicing: 2 isoforms: Q96BY6-1 Q96BY6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK10: NX_Q96BY6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96BY6

DOCK10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055504.2

ENSEMBL proteins:

ENSP00000386392 ENSP00000386694 ENSP00000258390 ENSP00000437947 ENSP00000395178

ENSP00000394552 ENSP00000397389

Reactome Protein details: Q96BY6
Human Recombinant Protein Products for DOCK10:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for DOCK10
	GenScript Custom Purified and Recombinant Proteins Services for DOCK10
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DOCK10

DOCK10 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DOCK10
	GenScript Custom Superior Antibodies Services for DOCK10
	Novus Biologicals DOCK10 Antibodies
	Abcam antibodies for DOCK10
	Uscn Antibodies for DOCK10
	Search ThermoFisher Antibodies for DOCK10

Assay Products for DOCK10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DOCK10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DOCK10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DOCK10 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR021816 DOCK_C/D_N

IPR027007 DOCK-C2

IPR026791 DOCK

IPR001849 Pleckstrin_homology

IPR026796 DOCK_D

Graphical View of Domain Structure for InterPro Entry Q96BY6

ProtoNet protein and cluster: Q96BY6

2 Blocks protein families:

IPB001849 Pleckstrin-like

IPB010703 Dedicator of cytokinesis

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Domain: The DHR-2 domain may mediate some GEF activity (By similarity)

Similarity: Belongs to the DOCK family

Similarity: Contains 1 DHR-1 domain

Similarity: Contains 1 DHR-2 domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DOC10_HUMAN, Q96BY6

Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging

bound GDP for free GTP

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	--	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005525	GTP binding	--	--
GO:0005543	phospholipid binding	IEA	--
GO:0017048	Rho GTPase binding	IEA	--

DOCK10 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DOCK10:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DOCK10

miRNA Products:		OriGene 3'-UTR Clone: DOCK10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK10
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK10:
		hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK10 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK10
		Sirion Biotech Custom design and validation of potent shRNA sequences against DOCK10

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DOCK10
			Sirion Biotech Customized adenovirus for overexpression of DOCK10 Sirion Biotech Customized adenovirus for potent knockdown of DOCK10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK10 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK10 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DOCK10 (NM_014689)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DOCK10
		Search LifeMap BioReagents cell lines for DOCK10
		Sirion Biotech Customized stable knockdown cell line services for DOCK10 Sirion Biotech Customized inducible knockdown cell line services for DOCK10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

1.00

Regulation of CDC42 activity

Regulation of CDC42 activity

1.00

Platelet activation, signaling and aggregation

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for DOCK10

Regulation of CDC42 activity

2 Reactome Pathways for DOCK10

	Hemostasis
	Factors involved in megakaryocyte development and platelet production

DOCK10 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DOCK10

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for DOCK10 (Q96BY6³ ENSP00000258390⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHOJ	Q9H4E5³, ENSP00000316729⁴	I2D: score=1 STRING: ENSP00000316729
LURAP1	Q96LR2³, ENSP00000361048⁴	I2D: score=3 STRING: ENSP00000361048
CDC42	ENSP00000314458⁴	STRING: ENSP00000314458

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--

DOCK10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DOCK10

3 HMDB Compounds for DOCK10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about DOCK10 / DOC10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DOCK10 gene (2 alternative transcripts):

NM_017718.1 NM_014689.2

Unigene Cluster for DOCK10:

Dedicator of cytokinesis 10

Hs.46578 [show with all ESTs]

Unigene Representative Sequence: NM_014689

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409802 ENST00000409592(uc002vob.2) ENST00000258390(uc002voa.2 uc002voc.2 uc010fwz.1)

ENST00000535663 ENST00000492251 ENST00000422684 ENST00000489831 ENST00000472652

ENST00000492369(uc002vod.1) ENST00000543715 ENST00000471810 ENST00000474102

ENST00000435582 ENST00000458608

miRNA Products:		OriGene 3'-UTR Clone: DOCK10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DOCK10
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK10:
		hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK10 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK10
		Sirion Biotech Custom design and validation of potent shRNA sequences against DOCK10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK10 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK10 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DOCK10 (NM_014689)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DOCK10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK10

Additional cDNA sequence:

AB014594.2 AB074179.1 AF250396.1 AK000227.1 AK001253.1 AK130257.1 AK293847.1 AK293879.1

AK307914.1 BC015018.1 CR749492.1 EU236710.2

13 DOTS entries:

DT.313890 DT.101978788 DT.91723314 DT.92035575 DT.100010125 DT.120985656 DT.120985681 DT.91981816

DT.120942277 DT.100717776 DT.40130726 DT.95368908 DT.95368909

1 AceView cDNA sequence:

BX493605

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22
SP1:																									-
SP2:																																											-
SP3:

ECgene alternative splicing isoforms for DOCK10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DOCK10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTCCAGT

About this image

DOCK10 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

See DOCK10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOCK10

SOURCE GeneReport for Unigene cluster: Hs.46578

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Tissue specificity: Expressed at low level in brain and lung

SABiosciences Custom PCR Arrays for DOCK10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DOCK10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DOCK10 gene from 7/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DOCK10¹	dedicator of cytokinesis 10	78.43(n) 82.88(a)		424803 XM_001234659.2 XP_001234660.2
lizard (Anolis carolinensis)	Reptilia	DOCK10⁶	--	81(a)	1 ↔ 1	3(24531326-24643059)
zebrafish (Danio rerio)	Actinopterygii	dock10¹	dedicator of cytokinesis 10	67.36(n) 70.24(a)		100000949 XM_001341012.4 XP_001341048.4
fruit fly (Drosophila melanogaster)	Insecta	CG42533⁶	--	33(a)	1 → many	2L(7472513-7496307)
worm (Caenorhabditis elegans)	Secernentea	F22G12.5⁶	--	21(a)	possible ortholog	I(13162488-13182797)
thale cress (Arabidopsis thaliana)	eudicotyledons	SPK1⁶	guanyl-nucleotide exchange factor / GTPase binding...	19(a)	1 → many	4(9228185-9241317)
rice (Oryza sativa)	Liliopsida	--	guanine nucleotide exchange factor, putative, expr...	22(a)	1 → many	3(12000006-12006559)

ENSEMBL Gene Tree for DOCK10 (if available)
TreeFam Gene Tree for DOCK10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DOCK10 gene

DOCK9² DOCK7² DOCK11² DOCK6² DOCK8²

10 SIMAP similar genes for DOCK10 using alignment to 7 protein entries: DOC10_HUMAN (see all proteins):

Nbla10300 DKFZp781A1532 DOCK10.2 DRIP2 DKFZp686N04132 DOCK11

DOCK9 DOCK7 DOCK6 DOCK8

DOCK10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193161011^1,2		--	225629307(+)	`GTACTA/GAGGCT`	1	--	ds500¹		0	--	--	--	--
rs7557657^1,2	C,A	--	225629474(+)	`gtcacA/Gtggtc`	1	--	ds500¹		1		NA	2
rs7584202^1,2	A	--	225629507(+)	`ggaaaC/Gtgcaa`	1	--	ds500¹		0	--	--	--	--
rs184351306^1,2		--	225629576(+)	`ACAGAC/TCTCAA`	1	--	ds500¹		0	--	--	--	--
rs74333489^1,2	C	--	225629643(+)	`ACCTCT/CGATCT`	1	--	ds500¹		2		CSA WA	120
rs76185447^1,2	F	--	225629687(+)	`AGATTT/AGAGTC`	1	--	ds500¹		1		EA	120
rs17271491^1,2	C,F	--	225629713(+)	`GGCAAG/AGCATC`	1	--	ds500¹		6		NA	266
rs74548362^1,2	F	--	225629788(+)	`CCCACT/GCTTCA`	1	--	ds500¹		1		WA	118
rs144192577^1,2		--	225630149(+)	`TGGGGC/TACTGA`	1	--	ut3¹		0	--	--	--	--
rs1045654^1,2	C,F,O,A,H	--	225630233(-)	`AGCCAA/GGTTGA`	1	--	ut3¹ ese³		31		MN EA NA NS WA CSA	3157

HapMap Linkage Disequilibrium report for DOCK10 (225629807 - 225879807 bp, first 250kb of DOCK10)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DOCK10
3 Indels: 42101 60349 26577

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK10

DNA2.0 Custom Variant and Variant Library Synthesis for DOCK10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DOCK10 for disorders           About GeneDecksing

OMIM gene information: 611518    OMIM disorders: --

1 disease for DOCK10:    About MalaCards

melanoma

Export disorders for DOCK10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DOCK10 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with DOCK10)

Utopia: connect your pdf to the dynamic
world of online information

Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)^{1, 2, 3} Cote J.-F. and Vuori K. (2002)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (1998)
Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PubMed id 18499258)^{1, 9} Yelo E....Parrado A. (2008)
Human and mouse DOCK10 splicing isoforms with alterna tive first coding exon usage are differentially expressed in T and B lymphocyte s. (PubMed id 21514340)¹ Alcaraz-GarcA-a M.J....Parrado A. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55619	HGNC: 23479	AceView: DOCK10.2	Ensembl:ENSG00000135905	euGenes: HUgn55619
ECgene: DOCK10	H-InvDB: DOCK10

(According to HUGE)
About This Section

HUGE: KIAA0694

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DOCK10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DOCK10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DOCK10 gene:
Search GeneIP for patents involving DOCK10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK10		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DOCK10
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	Browse OriGene siRNAs		OriGene 3'-UTR Clone for DOCK10
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK10		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK10
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DOCK10		OriGene Custom Protein Services for DOCK10
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DOCK10
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DOCK10
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK10
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK10
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK10
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK10

	GenScript Custom Purified and Recombinant Proteins Services for DOCK10		GenScript cDNA clones with any tag delivered in your preferred vector for DOCK10
	GenScript Custom Assay Services for DOCK10		GenScript Custom Superior Antibodies Services for DOCK10
	GenScript Custom overexpressing Cell Line Services for DOCK10		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DOCK10 promoter
	Search Chromatin IP Primers for DOCK10
	RT² qPCR Primer Assay in human, mouse, rat DOCK10
	Search GNC Networks for DOCK10
	SABiosciences Custom PCR Arrays for DOCK10

Search Tocris compounds for DOCK10

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DOCK10 antibodies

	Antibodies for DOCK10
	See all of Abcam's Antibodies, Kits and Proteins for DOCK10
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

DOCK10 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DOCK10

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

	SwitchGear 3'UTR luciferase reporter plasmids for DOCK10
	SwitchGear Promoter luciferase reporter plasmids for DOCK10

Search ThermoFisher Antibodies for DOCK10

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DOCK10

Sirion Biotech Customized:

	stable knockdown cell line services for DOCK10
	inducible knockdown cell line services for DOCK10
	design and validation of potent shRNA sequences against DOCK10
	adenovirus for potent knockdown of DOCK10
	adenovirus for overexpression of DOCK10
	stable overexpressing cell line services
	inducible overexpressing cell line services

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DOCK10 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

DOCK10 Gene

dedicator of cytokinesis 10

Aliases
for DOCK10 gene

Summaries
for DOCK10 gene

Genomic Views
for DOCK10 gene

Proteins
for DOCK10 gene

Protein Domains /
Families
for DOCK10 gene

Function
for DOCK10 gene

Pathways & Interactions
for DOCK10 gene

Drugs & Compounds
for DOCK10 gene

Transcripts
for DOCK10 gene

Expression
for DOCK10 gene

Orthologs
for DOCK10 gene

Paralogs
for DOCK10 gene

Genomic Variants
for DOCK10 gene

Disorders / Diseases
for DOCK10 gene

Publications
for DOCK10 gene

External Searches for DOCK10 gene

Genome Databases showing DOCK10 gene

Other Databases showing DOCK10 gene

Specialized Databases showing DOCK10 gene

Intellectual Property
for DOCK10 gene

Products
for DOCK10 gene

View Random Gene

Advanced Search

Export list of displayed genes

DOCK10 Gene

dedicator of cytokinesis 10

Aliasesfor DOCK10 gene

Summariesfor DOCK10 gene

Genomic Viewsfor DOCK10 gene

Proteinsfor DOCK10 gene

Protein Domains /Familiesfor DOCK10 gene

Functionfor DOCK10 gene

Pathways & Interactionsfor DOCK10 gene

Drugs & Compoundsfor DOCK10 gene

Transcriptsfor DOCK10 gene

Expression for DOCK10 gene

Orthologsfor DOCK10 gene

Paralogsfor DOCK10 gene

Genomic Variantsfor DOCK10 gene

Disorders / Diseasesfor DOCK10 gene

Publicationsfor DOCK10 gene

External Searches for DOCK10 gene

Genome Databases showing DOCK10 gene

Other Databases showing DOCK10 gene

Specialized Databases showing DOCK10 gene

Intellectual Propertyfor DOCK10 gene

Productsfor DOCK10 gene

View Random Gene

Aliases
for DOCK10 gene

Summaries
for DOCK10 gene

Genomic Views
for DOCK10 gene

Proteins
for DOCK10 gene

Protein Domains /
Families
for DOCK10 gene

Function
for DOCK10 gene

Pathways & Interactions
for DOCK10 gene

Drugs & Compounds
for DOCK10 gene

Transcripts
for DOCK10 gene

Expression
for DOCK10 gene

Orthologs
for DOCK10 gene

Paralogs
for DOCK10 gene

Genomic Variants
for DOCK10 gene

Disorders / Diseases
for DOCK10 gene

Publications
for DOCK10 gene

Intellectual Property
for DOCK10 gene

Products
for DOCK10 gene