Aliases for DOCK10 Gene
Aliases for DOCK10 Gene
External Ids for DOCK10 Gene
- HGNC: 23479
- Entrez Gene: 55619
- Ensembl: ENSG00000135905
- OMIM: 611518
- UniProtKB: Q96BY6
Previous GeneCards Identifiers for DOCK10 Gene
- GC02M225593
- GC02M225832
- GC02M225455
- GC02M225338
- GC02M217481
Summaries for DOCK10 Gene
-
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
GeneCards Summary for DOCK10 Gene
DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Regulation of CDC42 activity and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.
UniProtKB/Swiss-Prot for DOCK10 Gene
-
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pahtway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK10 Gene
Genomics for DOCK10 Gene
Regulatory Elements for DOCK10 Gene
Enhancers for DOCK10 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G224881 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 29.7 | +158.1 | 158148 | 6.0 | CTCF MAX RAD21 RELA YY1 GATA3 CBX5 EED RELB FOS | DOCK10 PIR37983 GC02P224823 |
| GH02G224943 | 1.5 | FANTOM5 ENCODE dbSUPER | 22.1 | +96.1 | 96072 | 6.9 | HDGF TBP PKNOX1 SIN3A RAD21 ZBTB40 GATA2 CBX5 FOS RELB | DOCK10 NYAP2 CUL3 PIR37983 MIR4439 |
| GH02G225009 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 17 | +31.7 | 31671 | 2.8 | JUN CHD1 NR3C1 FOSL1 JUND ATF3 GATA2 GLIS1 EHMT2 FOS | DOCK10 NYAP2 MIR4439 |
| GH02G225037 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 11.1 | +2.1 | 2123 | 6.2 | TBP TBL1XR1 SIN3A BMI1 ZBTB40 EGR1 RELB ETV6 IKZF2 CREM | DOCK10 NYAP2 CUL3 MIR4439 |
| GH02G224921 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 10.4 | +117.3 | 117292 | 8.1 | HDGF PKNOX1 JUN BACH1 BMI1 ARID3A GATA2 CBX5 EED FOS | DOCK10 NYAP2 CUL3 PIR37983 GC02P224823 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around DOCK10 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the DOCK10 gene promoter:
Regulatory Element Products
Genomic Location for DOCK10 Gene
- Chromosome:
- 2
- Start:
- 224,765,090 bp from pter
- End:
- 225,042,613 bp from pter
- Size:
- 277,524 bases
- Orientation:
- Minus strand
Genomic View for DOCK10 Gene
Genes around DOCK10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.2 by Ensembl
- 2q36.2 by Entrez Gene
- 2q36.2 by HGNC
DOCK10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DOCK10 Gene
Proteins for DOCK10 Gene
-
Protein details for DOCK10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96BY6-DOC10_HUMAN
- Recommended name:
- Dedicator of cytokinesis protein 10
- Protein Accession:
- Q96BY6
- B3FL70
- O75178
- Q68DA4
- Q9NW06
- Q9NXI8
Protein attributes for DOCK10 Gene
- Size:
- 2186 amino acids
- Molecular mass:
- 249531 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- Zizim means spike in Hebrew.
- SequenceCaution:
-
- Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91022.1; Type=Frameshift; Positions=2133; Evidence={ECO:0000305}; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18316.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for DOCK10 Gene
Post-translational modifications for DOCK10 Gene
Other Protein References for DOCK10 Gene
Antibody Products
- Novus Biologicals Antibodies for DOCK10
-
Abcam antibodies for DOCK10
- Invitrogen Antibodies for DOCK10
- antibodies-online Antibodies for DOCK10: See all 5
- Search GeneTex for Antibodies for DOCK10
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DOCK10
- Origene Custom Protein Services for DOCK10
- Novus Biologicals proteins for DOCK10
- Search GeneTex for Proteins for DOCK10
Assay Products
No data available for DME Specific Peptides for DOCK10 Gene
Domains & Families for DOCK10 Gene
Gene Families for DOCK10 Gene
Protein Domains for DOCK10 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DOCK10 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96BY6UniProtKB/Swiss-Prot:
DOC10_HUMAN :- The DHR-2 domain may mediate some GEF activity.
- Belongs to the DOCK family.
- Domain:
-
- The DHR-2 domain may mediate some GEF activity.
- Family:
-
- Belongs to the DOCK family.
Function for DOCK10 Gene
Molecular function for DOCK10 Gene
- UniProtKB/Swiss-Prot Function:
- Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pahtway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
- UniProtKB/Swiss-Prot Induction:
- Isoforms 1 and 2 are up-regulated in response to IL4 in B-cells but not T-cells.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0005085 | guanyl-nucleotide exchange factor activity | ISS,IEA | -- |
Phenotypes for DOCK10 Gene
- MGI mutant phenotypes for DOCK10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DOCK10:
Animal Models for DOCK10 Gene
- MGI Knock Outs for DOCK10:
-
- Dock10 tm1a(EUCOMM)Hmgu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DOCK10
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DOCK10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DOCK10 gene
- Search ViGene Biosciences for DOCK10
CRISPR Products
-
OriGene CRISPR knockouts for DOCK10
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOCK10
- GenScript: Design CRISPR guide RNA sequences for DOCK10
miRNA for DOCK10 Gene
- miRTarBase miRNAs that target DOCK10
miRNA Products
- Search ViGene Biosciences for DOCK10
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for DOCK10
- Browse OriGene Inhibitory RNA Products For DOCK10
-
ViGene Biosciences ready-to-package AAV shRNAs for DOCK10 gene
Clone Products
- Sino Biological Human cDNA Clone for DOCK10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DOCK10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DOCK10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for DOCK10
-
ViGene Biosciences adenoviral particle packaged cDNA for DOCK10 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DOCK10 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DOCK10 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-13175) for DOCK10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK10 Gene
Localization for DOCK10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DOCK10 Gene
- Nucleus. Cytoplasm. Cell projection, dendritic spine.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| mitochondrion | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | IDA | 18499258 |
| GO:0005737 | cytoplasm | IDA | 18499258 |
| GO:0016020 | membrane | IDA | 19946888 |
| GO:0043197 | dendritic spine | ISS | -- |
Pathways & Interactions for DOCK10 Gene
Pathways by source for DOCK10 Gene
1 BioSystems pathway for DOCK10 Gene
2 Reactome pathways for DOCK10 Gene
Interacting Proteins for DOCK10 Gene
Selected Interacting proteins:
ENSP00000258390
Q96BY6-DOC10_HUMAN
for DOCK10 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001782 | B cell homeostasis | ISS | -- |
| GO:0002315 | marginal zone B cell differentiation | ISS | -- |
| GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
| GO:0030334 | regulation of cell migration | IDA | 18835169 |
| GO:0043547 | positive regulation of GTPase activity | ISS,IEA | -- |
No data available for SIGNOR curated interactions for DOCK10 Gene
Transcripts for DOCK10 Gene
mRNA/cDNA for DOCK10 Gene
- (12) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (60) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DOCK10 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DOCK10
-
Santa Cruz Biotechnology (SCBT) CRISPR for DOCK10
- GenScript: Design CRISPR guide RNA sequences for DOCK10
miRNA Products
- Search ViGene Biosciences for DOCK10
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for DOCK10
- Browse OriGene Inhibitory RNA Products For DOCK10
-
ViGene Biosciences ready-to-package AAV shRNAs for DOCK10 gene
Clone Products
- Sino Biological Human cDNA Clone for DOCK10
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DOCK10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DOCK10
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-13175) for DOCK10
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: |
Expression for DOCK10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Spinal Cord (Nervous System)
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
-
Blood (Cardiovascular System)
- T-Cytotoxic Cells Thymus
- Endothelium (Cardiovascular System)
- Oligodendrocytes (Nervous System)
- Glial Cells (Uncategorized)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for DOCK10 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).
This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lymph node (15.8), CD8 Tcells (6.9), and Pancreas (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOCK10 Gene
NURSA nuclear receptor signaling pathways regulating expression of DOCK10 Gene:
DOCK10SOURCE GeneReport for Unigene cluster for DOCK10 Gene:
Hs.46578mRNA Expression by UniProt/SwissProt for DOCK10 Gene:
Q96BY6-DOC10_HUMAN
Tissue specificity:
Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
Evidence on tissue expression from TISSUES for DOCK10 Gene
- Nervous system(4.6)
- Blood(4.3)
- Bone marrow(4.2)
- Intestine(4.2)
- Skin(4.1)
Primer Products
-
OriGene qPCR primer pairs for DOCK10
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK10 Gene
Orthologs for DOCK10 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DOCK10 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | DOCK10 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | DOCK10 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Dock10 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dock10 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DOCK10 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | DOCK10 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | DOCK10 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dock10 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dock10 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for DOCK10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DOCK10 Gene
(9) SIMAP similar genes for DOCK10 Gene using alignment to 6 proteins:
Variants for DOCK10 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000042374 | -- | 224,923,105(+) | TATAT(A/G)AGAAT | intron-variant | |
| rs1000044143 | -- | 224,920,341(+) | AGTGC(A/T)GGGAT | intron-variant | |
| rs1000050959 | -- | 224,791,444(+) | AGTTT(G/T)CTTTG | intron-variant | |
| rs1000058239 | -- | 224,963,724(+) | AAGTA(A/G)TAATT | intron-variant | |
| rs1000084773 | -- | 224,855,576(+) | TGCGG(A/C)CACCC | intron-variant |
Residual Variation Intolerance Score:
27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.65;
91.40% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for DOCK10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DOCK10
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK10 Gene
Disorders for DOCK10 Gene
Relevant External Links for DOCK10
No disorders were found for DOCK10 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK10 Gene
Publications for DOCK10 Gene
- Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E. … Parrado A. (Mol. Immunol. 2008) 3 4 22 64
- Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3 4 64
- Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PMID: 21514340) Alcaraz-Garcia M.J. … Parrado A. (Hum. Immunol. 2011) 3 4 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
Products for DOCK10 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for DOCK10
- Origene Custom Protein Services for DOCK10
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DOCK10
- Browse OriGene Inhibitory RNA Products For DOCK10
- OriGene qPCR primer pairs for DOCK10
- OriGene CRISPR knockouts for DOCK10
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DOCK10
- GenScript: Next-day shipping cDNA ORF clone for DOCK10 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DOCK10
- GenScript Custom Assay Services for DOCK10
- GenScript Custom overexpressing Cell Line Services for DOCK10
- GenScript: Design CRISPR guide RNA sequences for DOCK10
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DOCK10
- Sino Biological Human cDNA Clone for DOCK10
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for DOCK10
- Novus Biologicals proteins for DOCK10
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for DOCK10 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DOCK10 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DOCK10 gene
- Search ViGene Biosciences for DOCK10
- Horizon Cell Lines for DOCK10
- Cyagen custom Knockout/knockin (KOKI) mouse models for DOCK10
- VectorBuilder custom plasmid, inducible vectors for DOCK10
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DOCK10
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for DOCK10 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
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