DOCK10 Gene

Aliases
for DOCK10 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02M225832 GC02M225455 GC02M225338 GC02M217481

Summaries
for DOCK10 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for DOCK10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NT_005403.18  NC_018913.2  

SwitchGear Promoter luciferase reporter plasmid: DOCK10 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK10

DOCK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M225593:  view genomic region     (about GC identifiers)

Proteins
for DOCK10 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for DOCK10: NX_Q96BY6

Explore proteomics data for DOCK10 at MOPED

Post-translational modifications: 

DOCK10 Human Recombinant Protein Products:

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	antibodies-online proteins for DOCK10
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Domains /
Families
for DOCK10 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96BY6

Find genes that share domains with DOCK10           About GenesLikeMe

Function
for DOCK10 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 5 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for DOCK10

miRNA Products:		miRTarBase miRNAs that target DOCK10: hsa-mir-142-3p (MIRT021604), hsa-mir-21-5p (MIRT030887), hsa-mir-132-3p (MIRT021826), hsa-mir-26b-5p (MIRT029588)
		Block miRNA regulation of human, mouse, rat DOCK10 using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate DOCK10:
		hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DOCK10
		Predesigned siRNA for gene silencing in human, mouse, rat DOCK10

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for DOCK10

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		GenScript: all cDNA clones in your preferred vector: DOCK10 (NM_014689)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

Flow Cytometry Products:

eBioscience FlowRNA Probe Sets ( VA1-13175) for DOCK10

Localization
for DOCK10 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	2
mitochondrion	2
nucleus	2
endoplasmic reticulum	1
extracellular	1
plasma membrane	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for DOCK10 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for DOCK10 About     See pathways by source

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	SuperPath	Contained pathways About
1	Hemostasis	Hemostasis 0.43
2	Regulation of CDC42 activity	Regulation of CDC42 activity
3	Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production

1 BioSystems Pathway for DOCK10

Regulation of CDC42 activity

1 Reactome Pathway for DOCK10

Factors involved in megakaryocyte development and platelet production

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for DOCK10 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for DOCK10 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for DOCK10 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DOCK10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAATTCCAGT

About this image

Brain (Nervous System)    fully expand to see all 3 entries
Oligodendrocyte Precursor Cells Forebrain White Matter
Oligodendrocyte-like cells
Spinal Cord (Nervous System)    fully expand to see all 2 entries
Oligodendrocyte-like cells
Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
Oligodendrocyte-like cells
Thymus (Hematopoietic System)
T-Cytotoxic Cells Thymus
Endothelium (Cardiovascular System)
Endothelial-like cells

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DOCK10
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOCK10
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		QuantiFast Probe-based Assays in human, mouse, rat DOCK10

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

Orthologs
for DOCK10 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for DOCK10 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for DOCK10 gene

DOCK9²  DOCK7²  DOCK11²  DOCK6²  DOCK8²  

9 SIMAP similar genes for DOCK10 using alignment to 6 protein entries:     DOC10_HUMAN (see all proteins):

Nbla10300    DKFZp781A1532    DRIP2    DKFZp686N04132    DOCK11    DOCK9

DOCK7    DOCK6    DOCK8

Find genes that share paralogs with DOCK10           About GenesLikeMe

Genomic Variants
for DOCK10 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DOCK10 (see all 5624)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs58390801,2	C	--	225173173(+)	AAAAA-/ACTCTT	1	--	int1 trp3		0	--	--	--	--
rs1931610111,2		--	225629307(+)	GTACTA/GAGGCT	1	--	ds5001		0	--	--	--	--
rs75576571,2	C,A	--	225629474(+)	gtcacA/Gtggtc	1	--	ds5001		1		NA	2
rs75842021,2	A	--	225629507(+)	ggaaaC/Gtgcaa	1	--	ds5001		0	--	--	--	--
rs1843513061,2		--	225629576(+)	ACAGAC/TCTCAA	1	--	ds5001		0	--	--	--	--
rs743334891,2	C	--	225629643(+)	ACCTCT/CGATCT	1	--	ds5001		2		CSA WA	120
rs761854471,2	F	--	225629687(+)	AGATTT/AGAGTC	1	--	ds5001		1		EA	120
rs172714911,2	C,F	--	225629713(+)	GGCAAG/AGCATC	1	--	ds5001		6		NA	266
rs745483621,2	F	--	225629788(+)	CCCACT/GCTTCA	1	--	ds5001		1		WA	118
rs1441925771,2	C	--	225630149(+)	TGGGGC/TACTGA	1	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for DOCK10 (225629807 - 225879807 bp, first 250kb of DOCK10)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for DOCK10 (see all 18):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2721534	CNV	Deletion	23290073
esv1631002	CNV	Deletion	17803354
esv2668530	CNV	Deletion	23128226
esv2663234	CNV	Deletion	23128226
esv2721535	CNV	Deletion	23290073
esv4249	CNV	Deletion	18987735
dgv674e201	CNV	Deletion	23290073
esv268262	CNV	Insertion	20981092
esv274230	CNV	Insertion	20981092
esv1010048	CNV	Insertion	20482838

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DOCK10

DNA2.0 Custom Variant and Variant Library Synthesis for DOCK10

Disorders / Diseases
for DOCK10 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for DOCK10 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)^{1, 2, 3} Cote J.-F. and Vuori K. (J. Cell Sci. 2002)
2. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PubMed id 21514340)^{1, 2} Alcaraz-Garcia M.J.... Parrado A. (Hum. Immunol. 2011)
3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (DNA Res. 2002)
8. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (DNA Res. 1998)
9. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PubMed id 18499258)^{1, 9} Yelo E....Parrado A. (Mol. Immunol. 2008)
10. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PubMed id 23967269)¹ Kim J.H....Shin H.D. (PLoS ONE 2013)

External Searches for DOCK10 gene

Genome Databases showing DOCK10 gene

Other Databases showing DOCK10 gene

Specialized Databases showing DOCK10 gene

Products
for DOCK10 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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