Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

DOCK10 Gene

protein-coding GIFtS: 57
GCID: GC02M225593

Dedicator Of Cytokinesis 10

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dedicator Of Cytokinesis 10¹ ²		Nbla10300²
ZIZ3² ³ ⁵		Dedicator Of Cytokinesis Protein 10²
zizimin3¹ ²		Dopamine Receptor Interacting Protein 2²
KIAA0694³ ⁵		Zizimin-3³
DRIP2²

External Ids:	HGNC: 23479¹	Entrez Gene: 55619²	Ensembl: ENSG00000135905⁷	OMIM: 611518⁵	UniProtKB: Q96BY6³

Export aliases for DOCK10 gene to outside databases

Previous GC identifers: GC02M225832 GC02M225455 GC02M225338 GC02M217481

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DOCK10 Gene:

This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine

nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The

encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal

pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been

described. (provided by RefSeq, Mar 2014)

GeneCards Summary for DOCK10 Gene:

DOCK10 (dedicator of cytokinesis 10) is a protein-coding gene. Diseases associated with DOCK10 include attention deficit hyperactivity disorder, and melanoma. GO annotations related to this gene include Rho GTPase binding and phospholipid binding. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by

exchanging bound GDP for free GTP

Gene Wiki entry for DOCK10 (Dock10) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000002.12 NT_005403.18 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the DOCK10 gene promoter:
STAT1 Elk-1 STAT1beta STAT6 CUTL1 STAT1alpha CREB STAT2 deltaCREB STAT3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK10 promoter sequence

Search Chromatin IP Primers for DOCK10

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.2 Ensembl cytogenetic band: 2q36.2 HGNC cytogenetic band: 2q36.3

DOCK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK10 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M225593: view genomic region (about GC identifiers)

Start:	225,629,807 bp from pter	End:	225,907,330 bp from pter
Size:	277,524 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6 (See protein sequence)

Recommended Name: Dedicator of cytokinesis protein 10

Size: 2186 amino acids; 249531 Da

Sequence caution: Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA91022.1;

Type=Frameshift; Positions=2133; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally

extended;

Secondary accessions: B3FL70 O75178 Q9NW06 Q9NXI8

Alternative splicing: 3 isoforms: Q96BY6-1 Q96BY6-2 Q96BY6-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK10: NX_Q96BY6

Explore proteomics data for DOCK10 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See DOCK10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001277192.1 NP_055504.2

ENSEMBL proteins:

ENSP00000386694 ENSP00000258390 ENSP00000437947 ENSP00000395178 ENSP00000394552

ENSP00000397389

Reactome Protein details: Q96BY6

DOCK10 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for DOCK10
	GenScript Custom Purified and Recombinant Proteins Services for DOCK10
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DOCK10

DOCK10 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DOCK10
	Novus Biologicals DOCK10 Antibodies
	Abcam antibodies for DOCK10
	Cloud-Clone Corp. Antibodies for DOCK10
	Search ThermoFisher Antibodies for DOCK10
	LSBio Antibodies in human, mouse, rat for DOCK10

DOCK10 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DOCK10
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DOCK10
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DOCK10 Cloud-Clone Corp. CLIAs for DOCK10

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

PLEKH: Pleckstrin homology (PH) domain containing

Selected InterPro protein domains (see all 8):

IPR021816 DOCK_C/D_N

IPR027007 DHR-1_domain

IPR026791 DOCK

IPR001849 Pleckstrin_homology

IPR026796 DOCK_D

Graphical View of Domain Structure for InterPro Entry Q96BY6

ProtoNet protein and cluster: Q96BY6

2 Blocks protein domains:

IPB001849 Pleckstrin-like

IPB010703 Dedicator of cytokinesis

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Domain: The DHR-2 domain may mediate some GEF activity (By similarity)

Similarity: Belongs to the DOCK family

Similarity: Contains 1 DHR-1 domain

Similarity: Contains 1 DHR-2 domain

Similarity: Contains 1 PH domain

DOCK10 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: DOC10_HUMAN, Q96BY6

Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by

exchanging bound GDP for free GTP

Induction: Isoforms 1 and 2 are up-regulated in response to interleukin-4

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005085	guanyl-nucleotide exchange factor activity	--	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005488	binding	--	--
GO:0017048	Rho GTPase binding	IEA	--

DOCK10 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DOCK10:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOCK10

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOCK10

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOCK10

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOCK10

miRNA Products:		miRTarBase miRNAs that target DOCK10: hsa-mir-142-3p (MIRT021604), hsa-mir-21-5p (MIRT030887), hsa-mir-132-3p (MIRT021826), hsa-mir-26b-5p (MIRT029588)

		Block miRNA regulation of human, mouse, rat DOCK10 using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate DOCK10:
		hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DOCK10
		Predesigned siRNA for gene silencing in human, mouse, rat DOCK10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DOCK10

Clone Products:		OriGene clones in human, mouse for DOCK10 (see all 6) OriGene ORF clones in mouse, rat for DOCK10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DOCK10 (NM_014689)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DOCK10
		Browse ESI BIO Cell Lines and PureStem Progenitors for DOCK10

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
mitochondrion	2
nucleus	2
endoplasmic reticulum	1
extracellular	1
plasma membrane	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0070062	extracellular vesicular exosome	IDA	--

DOCK10 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for DOCK10 About

See pathways by source

SuperPath

Contained pathways About

Hemostasis

Hemostasis

0.43

Regulation of CDC42 activity

Regulation of CDC42 activity

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for DOCK10

Regulation of CDC42 activity

1 Reactome Pathway for DOCK10

Factors involved in megakaryocyte development and platelet production

DOCK10 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DOCK10
Interactions:

Search GeneGlobe Interaction Network for DOCK10

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for DOCK10 (Q96BY6³ ENSP00000258390⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHOJ	Q9H4E5³, ENSP00000316729⁴	I2D: score=1 STRING: ENSP00000316729
LURAP1	Q96LR2³, ENSP00000361048⁴	I2D: score=3 STRING: ENSP00000361048
CDC42	ENSP00000314458⁴	STRING: ENSP00000314458
NCKAP1	ENSP00000354251⁴	STRING: ENSP00000354251
NCKAP1L	ENSP00000293373⁴	STRING: ENSP00000293373

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0030334	regulation of cell migration	IDA	18835169

DOCK10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DOCK10 (DOC10)

3 HMDB Compounds for DOCK10 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DOCK10 gene (3 alternative transcripts):

NM_001290263.1 NM_014689.2 NM_017718.1

Unigene Cluster for DOCK10:

Dedicator of cytokinesis 10

Hs.46578 [show with all ESTs]

Unigene Representative Sequence: NM_014689

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409592(uc002vob.2) ENST00000258390(uc002voa.2 uc002voc.2 uc010fwz.1)

ENST00000535663 ENST00000492251 ENST00000422684 ENST00000489831 ENST00000472652

ENST00000492369(uc002vod.1) ENST00000543715 ENST00000471810 ENST00000474102

ENST00000435582 ENST00000458608

miRNA Products:		Block miRNA regulation of human, mouse, rat DOCK10 using miScript Target Protectors
		6 qRT-PCR Assays for microRNAs that regulate DOCK10:
		hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
		SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DOCK10
		Predesigned siRNA for gene silencing in human, mouse, rat DOCK10

Clone Products:		OriGene clones in human, mouse for DOCK10 (see all 6) OriGene ORF clones in mouse, rat for DOCK10 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DOCK10 (NM_014689)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DOCK10
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DOCK10
		QuantiTect SYBR Green Assays in human, mouse, rat DOCK10
		QuantiFast Probe-based Assays in human, mouse, rat DOCK10

Additional mRNA sequence:

AB014594.2 AB074179.1 AF250396.1 AK000227.1 AK001253.1 AK130257.1 AK293847.1 AK293879.1

AK307914.1 BC015018.1 CR749492.1 EU236710.2

13 DOTS entries:

DT.313890 DT.101978788 DT.91723314 DT.92035575 DT.100010125 DT.120985656 DT.120985681 DT.91981816

DT.120942277 DT.100717776 DT.40130726 DT.95368908 DT.95368909

1 AceView cDNA sequence:

BX493605

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22
SP1:																									-
SP2:																																											-
SP3:

ECgene alternative splicing isoforms for DOCK10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DOCK10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAATTCCAGT

About this image

DOCK10 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Brain (Nervous System) fully expand to see all 3 entries
Oligodendrocyte Precursor Cells Forebrain White Matter
Oligodendrocyte-like cells

Spinal Cord (Nervous System) fully expand to see all 2 entries
Oligodendrocyte-like cells

Oligodendrocytes (Nervous System) fully expand to see all 2 entries
Oligodendrocyte-like cells

Thymus (Hematopoietic System)
T-Cytotoxic Cells Thymus

Endothelium (Cardiovascular System)
Endothelial-like cells

DOCK10 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DOCK10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.46578

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6

Tissue specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3

is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells

Custom PCR Arrays for DOCK10

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for DOCK10
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DOCK10
		QuantiTect SYBR Green Assays in human, mouse, rat DOCK10
		QuantiFast Probe-based Assays in human, mouse, rat DOCK10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for DOCK10 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dock10^{1 , 5}	dedicator of cytokinesis 10^{1, 5}	87.44(n)¹ 93.78(a)¹		1 (41.41 cM)⁵ 210293¹ NM_175291.4¹ NP_780500.2¹ 80501073⁵
chicken (Gallus gallus)	Aves	DOCK10¹	dedicator of cytokinesis 10	78.37(n) 82.75(a)		424803 XM_001234659.3 XP_001234660.2
lizard (Anolis carolinensis)	Reptilia	DOCK10⁶	dedicator of cytokinesis 10	81(a)	1 ↔ 1	3(24454172-24644014)
tropical clawed frog (Xenopus tropicalis)	Amphibia	dock10¹	dedicator of cytokinesis 10	71.93(n) 74.5(a)		100127561 XM_002937096.2 XP_002937142.2
zebrafish (Danio rerio)	Actinopterygii	dock10¹	dedicator of cytokinesis 10	67.16(n) 69.77(a)		100000949 XM_001341012.5 XP_001341048.5

ENSEMBL Gene Tree for DOCK10 (if available)
TreeFam Gene Tree for DOCK10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for DOCK10 gene

DOCK9² DOCK7² DOCK11² DOCK6² DOCK8²

9 SIMAP similar genes for DOCK10 using alignment to 6 protein entries: DOC10_HUMAN (see all proteins):

Nbla10300 DKFZp781A1532 DRIP2 DKFZp686N04132 DOCK11 DOCK9

DOCK7 DOCK6 DOCK8

DOCK10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs5839080^1,2	C	--	225173173(+)	`AAAAA-/ACTCTT`	1	--	int¹ trp³		0	--	--	--	--
rs193161011^1,2		--	225629307(+)	`GTACTA/GAGGCT`	1	--	ds500¹		0	--	--	--	--
rs7557657^1,2	C,A	--	225629474(+)	`gtcacA/Gtggtc`	1	--	ds500¹		1		NA	2
rs7584202^1,2	A	--	225629507(+)	`ggaaaC/Gtgcaa`	1	--	ds500¹		0	--	--	--	--
rs184351306^1,2		--	225629576(+)	`ACAGAC/TCTCAA`	1	--	ds500¹		0	--	--	--	--
rs74333489^1,2	C	--	225629643(+)	`ACCTCT/CGATCT`	1	--	ds500¹		2		CSA WA	120
rs76185447^1,2	F	--	225629687(+)	`AGATTT/AGAGTC`	1	--	ds500¹		1		EA	120
rs17271491^1,2	C,F	--	225629713(+)	`GGCAAG/AGCATC`	1	--	ds500¹		6		NA	266
rs74548362^1,2	F	--	225629788(+)	`CCCACT/GCTTCA`	1	--	ds500¹		1		WA	118
rs144192577^1,2	C	--	225630149(+)	`TGGGGC/TACTGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DOCK10 (225629807 - 225879807 bp, first 250kb of DOCK10)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for DOCK10 (see all 18): About this table

Variant ID	Type	Subtype	PubMed ID
esv2721534	CNV	Deletion	23290073
esv1631002	CNV	Deletion	17803354
esv2668530	CNV	Deletion	23128226
esv2663234	CNV	Deletion	23128226
esv2721535	CNV	Deletion	23290073
esv4249	CNV	Deletion	18987735
dgv674e201	CNV	Deletion	23290073
esv268262	CNV	Insertion	20981092
esv274230	CNV	Insertion	20981092
esv1010048	CNV	Insertion	20482838

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DOCK10

DNA2.0 Custom Variant and Variant Library Synthesis for DOCK10

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 611518 OMIM disorders: --

2 diseases for DOCK10:
About MalaCards

attention deficit hyperactivity disorder melanoma

DOCK10 for disorders About GeneDecksing

Genetic Association Database (GAD): DOCK10

Export disorders for DOCK10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DOCK10 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with DOCK10)

Utopia: connect your pdf to the dynamic
world of online information

Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)^{1, 2, 3} Cote J.-F. and Vuori K. (J. Cell Sci. 2002)
Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PubMed id 21514340)^{1, 2} Alcaraz-Garcia M.J.... Parrado A. (Hum. Immunol. 2011)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W.... Wilson R.K. (Nature 2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (DNA Res. 2002)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (DNA Res. 1998)
Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PubMed id 18499258)^{1, 9} Yelo E....Parrado A. (Mol. Immunol. 2008)
A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PubMed id 23967269)¹ Kim J.H....Shin H.D. (PLoS ONE 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 55619	HGNC: 23479	AceView: DOCK10.2	Ensembl:ENSG00000135905	euGenes: HUgn55619
ECgene: DOCK10	H-InvDB: DOCK10

(According to HUGE)
About This Section

TryGeneCards Plus

HUGE: KIAA0694

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for DOCK10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DOCK10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for DOCK10 gene:
Search GeneIP for patents involving DOCK10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for DOCK10
	Browse OriGene qPCR primer pairs and template standards		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for DOCK10
	OriGene qSTAR qPCR primer pairs in human, mouse for DOCK10		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for DOCK10		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DOCK10		OriGene Custom Protein Services for DOCK10

	Block miRNA regulation of human, mouse, rat DOCK10 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing DOCK10
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK10		Predesigned siRNA for gene silencing in human, mouse, rat DOCK10
	QuantiFast Probe-based Assays in human, mouse, rat DOCK10		QuantiTect SYBR Green Assays in human, mouse, rat DOCK10
	Custom PCR Arrays for DOCK10		Search Chromatin IP Primers for DOCK10
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat DOCK10		Search GeneGlobe Interaction Network for DOCK10
	Regulatory tfbs in DOCK10 promoter

	GenScript Custom Purified and Recombinant Proteins Services for DOCK10		GenScript cDNA clones with any tag delivered in your preferred vector for DOCK10
	GenScript Custom Assay Services for DOCK10		GenScript Custom overexpressing Cell Line Services for DOCK10
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for DOCK10 (DOC10)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DOCK10 antibodies

	Antibodies for DOCK10
	See all of Abcam's Antibodies, Kits and Proteins for DOCK10
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for DOCK10
	Antibodies for DOCK10
	ELISAs for DOCK10
	CLIAs for DOCK10

Browse ESI BIO Cell Lines and PureStem Progenitors for DOCK10

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

	SwitchGear 3'UTR luciferase reporter plasmids for DOCK10
	SwitchGear Promoter luciferase reporter plasmids for DOCK10

Search ThermoFisher Antibodies for DOCK10

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOCK10
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOCK10

LSBio Antibodies in human, mouse, rat for DOCK10

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DOCK10 gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

DOCK10 Gene

Dedicator Of Cytokinesis 10

Aliases
for DOCK10 gene

Summaries
for DOCK10 gene

Genomic Views
for DOCK10 gene

Proteins
for DOCK10 gene

DOCK10 Human Recombinant Protein Products:

DOCK10 Antibody Products:

DOCK10 Assay Products:

Domains /
Families
for DOCK10 gene

Function
for DOCK10 gene

Localization
for DOCK10 gene

Pathways & Interactions
for DOCK10 gene

Drugs & Compounds
for DOCK10 gene

Transcripts
for DOCK10 gene

Expression
for DOCK10 gene

Orthologs
for DOCK10 gene

Paralogs
for DOCK10 gene

Genomic Variants
for DOCK10 gene

Disorders / Diseases
for DOCK10 gene

Publications
for DOCK10 gene

External Searches for DOCK10 gene

Genome Databases showing DOCK10 gene

Other Databases showing DOCK10 gene

Specialized Databases showing DOCK10 gene

Intellectual Property
for DOCK10 gene

Products
for DOCK10 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

DOCK10 Gene

Dedicator Of Cytokinesis 10

Aliasesfor DOCK10 gene

Summariesfor DOCK10 gene

Genomic Viewsfor DOCK10 gene

Proteinsfor DOCK10 gene

DOCK10 Human Recombinant Protein Products:

DOCK10 Antibody Products:

DOCK10 Assay Products:

Domains /Familiesfor DOCK10 gene

Functionfor DOCK10 gene

Localizationfor DOCK10 gene

Pathways & Interactionsfor DOCK10 gene

Drugs & Compoundsfor DOCK10 gene

Transcriptsfor DOCK10 gene

Expression for DOCK10 gene

Orthologsfor DOCK10 gene

Paralogsfor DOCK10 gene

Genomic Variantsfor DOCK10 gene

Disorders / Diseasesfor DOCK10 gene

Publicationsfor DOCK10 gene

External Searches for DOCK10 gene

Genome Databases showing DOCK10 gene

Other Databases showing DOCK10 gene

Specialized Databases showing DOCK10 gene

Intellectual Propertyfor DOCK10 gene

Productsfor DOCK10 gene

View Random Gene

Aliases
for DOCK10 gene

Summaries
for DOCK10 gene

Genomic Views
for DOCK10 gene

Proteins
for DOCK10 gene

Domains /
Families
for DOCK10 gene

Function
for DOCK10 gene

Localization
for DOCK10 gene

Pathways & Interactions
for DOCK10 gene

Drugs & Compounds
for DOCK10 gene

Transcripts
for DOCK10 gene

Expression
for DOCK10 gene

Orthologs
for DOCK10 gene

Paralogs
for DOCK10 gene

Genomic Variants
for DOCK10 gene

Disorders / Diseases
for DOCK10 gene

Publications
for DOCK10 gene

Intellectual Property
for DOCK10 gene

Products
for DOCK10 gene