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DOCK10 Gene(Protein Coding)

Dedicator Of Cytokinesis 10

GCID:
GC02M224765
GIFtS:
54
Genes Participants
UDN Logo

Aliases for DOCK10 Gene

Aliases for DOCK10 Gene

  • Dedicator Of Cytokinesis 10 2 3 5
  • Zizimin3 2 3
  • ZIZ3 3 4
  • Dopamine Receptor Interacting Protein 2 3
  • Dedicator Of Cytokinesis Protein 10 3
  • Nbla10300 3
  • Zizimin-3 4
  • KIAA0694 4
  • DRIP2 3

External Ids for DOCK10 Gene

Previous GeneCards Identifiers for DOCK10 Gene

  • GC02M225593
  • GC02M225832
  • GC02M225455
  • GC02M225338
  • GC02M217481

Summaries for DOCK10 Gene

Entrez Gene Summary for DOCK10 Gene

  • This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for DOCK10 Gene

DOCK10 (Dedicator Of Cytokinesis 10) is a Protein Coding gene. Among its related pathways are Regulation of CDC42 activity and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot for DOCK10 Gene

  • Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pahtway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.

Gene Wiki entry for DOCK10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK10 Gene

Genomics for DOCK10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DOCK10 Gene

Enhancers for DOCK10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G224881 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29.7 +158.1 158148 6.0 CTCF MAX RAD21 RELA YY1 GATA3 ARID3A CBX5 EED RELB DOCK10 PIR37983 GC02P224823
GH02G224943 1.5 FANTOM5 ENCODE dbSUPER 22.1 +96.1 96072 6.9 HDGF TBP PKNOX1 SIN3A RAD21 ZBTB40 GATA2 CBX5 FOS RELB DOCK10 NYAP2 CUL3 PIR37983 MIR4439
GH02G225009 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17 +31.7 31671 2.8 JUN CHD1 NR3C1 FOSL1 JUND ATF3 GATA2 GLIS1 EHMT2 FOS DOCK10 NYAP2 MIR4439
GH02G225037 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +2.1 2123 6.2 TBP TBL1XR1 SIN3A BMI1 ZBTB40 EGR1 RELB ETV6 IKZF2 CREM DOCK10 NYAP2 CUL3 MIR4439
GH02G224921 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +117.3 117292 8.1 HDGF PKNOX1 JUN BACH1 BMI1 ARID3A GATA2 CBX5 EED FOS DOCK10 NYAP2 CUL3 PIR37983 GC02P224823
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DOCK10 on UCSC Golden Path with GeneCards custom track

Promoters for DOCK10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000131168 613 2001 TBP TBL1XR1 SIN3A BMI1 EGR1 RELB ETV6 IKZF2 CREM EGR2

Transcription factor binding sites by QIAGEN in the DOCK10 gene promoter:

Genomic Location for DOCK10 Gene

Chromosome:
2
Start:
224,765,090 bp from pter
End:
225,042,613 bp from pter
Size:
277,524 bases
Orientation:
Minus strand

Genomic View for DOCK10 Gene

Genes around DOCK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DOCK10 Gene

Proteins for DOCK10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DOCK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BY6-DOC10_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 10
    Protein Accession:
    Q96BY6
    Secondary Accessions:
    • B3FL70
    • O75178
    • Q68DA4
    • Q9NW06
    • Q9NXI8

    Protein attributes for DOCK10 Gene

    Size:
    2186 amino acids
    Molecular mass:
    249531 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Zizim means spike in Hebrew.
    SequenceCaution:
    • Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA91022.1; Type=Frameshift; Positions=2133; Evidence={ECO:0000305}; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18316.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DOCK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOCK10 Gene

Protein Expression for DOCK10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DOCK10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOCK10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DOCK10 Gene

Domains & Families for DOCK10 Gene

Gene Families for DOCK10 Gene

HGNC:

Protein Domains for DOCK10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DOCK10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BY6

UniProtKB/Swiss-Prot:

DOC10_HUMAN :
  • The DHR-2 domain may mediate some GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain may mediate some GEF activity.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK10: view

Function for DOCK10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DOCK10 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pahtway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
UniProtKB/Swiss-Prot Induction:
Isoforms 1 and 2 are up-regulated in response to IL4 in B-cells but not T-cells.

Gene Ontology (GO) - Molecular Function for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005085 guanyl-nucleotide exchange factor activity ISS,IEA --
genes like me logo Genes that share ontologies with DOCK10: view
genes like me logo Genes that share phenotypes with DOCK10: view

Animal Models for DOCK10 Gene

MGI Knock Outs for DOCK10:

Animal Model Products

CRISPR Products

miRNA for DOCK10 Gene

miRTarBase miRNAs that target DOCK10

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK10 Gene

Localization for DOCK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK10 Gene

Nucleus. Cytoplasm. Cell projection, dendritic spine.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK10 gene
Compartment Confidence
extracellular 5
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 18499258
GO:0005737 cytoplasm IDA 18499258
GO:0016020 membrane IDA 19946888
GO:0043197 dendritic spine ISS --
genes like me logo Genes that share ontologies with DOCK10: view

Pathways & Interactions for DOCK10 Gene

genes like me logo Genes that share pathways with DOCK10: view

Pathways by source for DOCK10 Gene

1 BioSystems pathway for DOCK10 Gene

Gene Ontology (GO) - Biological Process for DOCK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis ISS --
GO:0002315 marginal zone B cell differentiation ISS --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0030334 regulation of cell migration IDA 18835169
GO:0043547 positive regulation of GTPase activity ISS,IEA --
genes like me logo Genes that share ontologies with DOCK10: view

No data available for SIGNOR curated interactions for DOCK10 Gene

Drugs & Compounds for DOCK10 Gene

Products:

  1. Drug

(3) Drugs for DOCK10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK10: view

Transcripts for DOCK10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DOCK10 Gene

(12) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOCK10 Gene

Dedicator of cytokinesis 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3:

Relevant External Links for DOCK10 Gene

GeneLoc Exon Structure for
DOCK10
ECgene alternative splicing isoforms for
DOCK10

Expression for DOCK10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOCK10 Gene

mRNA expression in normal human tissues for DOCK10 Gene
mRNA expression by BioGPS for DOCK10 GenemRNA expression by GTEx for DOCK10 Gene

mRNA differential expression in normal tissues according to GTEx for DOCK10 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.6).

Protein differential expression in normal tissues from HIPED for DOCK10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.2), Lymph node (15.8), CD8 Tcells (6.9), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOCK10 Gene



NURSA nuclear receptor signaling pathways regulating expression of DOCK10 Gene:

DOCK10

SOURCE GeneReport for Unigene cluster for DOCK10 Gene:

Hs.46578

mRNA Expression by UniProt/SwissProt for DOCK10 Gene:

Q96BY6-DOC10_HUMAN
Tissue specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.

Evidence on tissue expression from TISSUES for DOCK10 Gene

  • Nervous system(4.6)
  • Blood(4.3)
  • Bone marrow(4.2)
  • Intestine(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DOCK10: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK10 Gene

Orthologs for DOCK10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DOCK10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DOCK10 34 35
  • 99.53 (n)
dog
(Canis familiaris)
 Mammalia DOCK10 34 35
  • 91.73 (n)
cow
(Bos Taurus)
 Mammalia DOCK10 34 35
  • 90.88 (n)
mouse
(Mus musculus)
 Mammalia Dock10 34 16 35
  • 87.44 (n)
rat
(Rattus norvegicus)
 Mammalia Dock10 34
  • 87.41 (n)
oppossum
(Monodelphis domestica)
 Mammalia DOCK10 35
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 84 (a)
 OneToMany
-- 35
  • 78 (a)
 OneToMany
-- 35
  • 73 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves DOCK10 34 35
  • 78.37 (n)
lizard
(Anolis carolinensis)
 Reptilia DOCK10 35
  • 81 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dock10 34
  • 71.93 (n)
zebrafish
(Danio rerio)
 Actinopterygii dock10 34 35
  • 67.16 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 59 (a)
 OneToOne
Species where no ortholog for DOCK10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOCK10 Gene

ENSEMBL:
Gene Tree for DOCK10 (if available)
TreeFam:
Gene Tree for DOCK10 (if available)

Paralogs for DOCK10 Gene

Paralogs for DOCK10 Gene

(9) SIMAP similar genes for DOCK10 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DOCK10: view

Variants for DOCK10 Gene

Sequence variations from dbSNP and Humsavar for DOCK10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000042374 -- 224,923,105(+) TATAT(A/G)AGAAT intron-variant
rs1000044143 -- 224,920,341(+) AGTGC(A/T)GGGAT intron-variant
rs1000050959 -- 224,791,444(+) AGTTT(G/T)CTTTG intron-variant
rs1000058239 -- 224,963,724(+) AAGTA(A/G)TAATT intron-variant
rs1000084773 -- 224,855,576(+) TGCGG(A/C)CACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK10 Gene

Variant ID Type Subtype PubMed ID
dgv2351e59 CNV duplication 20981092
dgv631e201 CNV deletion 23290073
esv1010048 CNV insertion 20482838
esv1011163 CNV insertion 20482838
esv1631002 CNV deletion 17803354
esv2663234 CNV deletion 23128226
esv2668530 CNV deletion 23128226
esv2721534 CNV deletion 23290073
esv2721535 CNV deletion 23290073
esv3303983 CNV mobile element insertion 20981092
esv3309958 CNV mobile element insertion 20981092
esv3326171 CNV insertion 20981092
esv3392806 CNV insertion 20981092
esv3405152 CNV insertion 20981092
esv3561074 CNV deletion 23714750
esv3594478 CNV gain 21293372
esv3594480 CNV loss 21293372
esv3594481 CNV loss 21293372
esv3594482 CNV loss 21293372
esv4249 CNV loss 18987735
esv8487 CNV gain 19470904
nsv1073014 CNV deletion 25765185
nsv1076504 CNV duplication 25765185
nsv1116001 CNV insertion 24896259
nsv1116831 CNV deletion 24896259
nsv1125776 CNV deletion 24896259
nsv1129212 CNV insertion 24896259
nsv1138892 CNV deletion 24896259
nsv1138893 CNV deletion 24896259
nsv3185 CNV deletion 18451855
nsv470519 CNV gain 18288195
nsv473288 CNV novel sequence insertion 20440878
nsv508131 OTHER sequence alteration 20534489
nsv517969 CNV loss 19592680
nsv954202 CNV deletion 24416366

Variation tolerance for DOCK10 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.65; 91.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOCK10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK10 Gene

Disorders for DOCK10 Gene

Relevant External Links for DOCK10

Genetic Association Database (GAD)
DOCK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOCK10

No disorders were found for DOCK10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK10 Gene

Publications for DOCK10 Gene

  1. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PMID: 18499258) Yelo E. … Parrado A. (Mol. Immunol. 2008) 3 4 22 64
  2. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Cote J.-F. … Vuori K. (J. Cell Sci. 2002) 2 3 4 64
  3. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PMID: 21514340) Alcaraz-Garcia M.J. … Parrado A. (Hum. Immunol. 2011) 3 4 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64

Products for DOCK10 Gene

Sources for DOCK10 Gene

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