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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DOCK10 Gene

protein-coding   GIFtS: 56
GCID: GC02M225593

dedicator of cytokinesis 10
 Explore 1 disease affiliated with
DOCK10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DOCK10    

Aliases
for DOCK10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dedicator Of Cytokinesis 101 2     Dopamine Receptor Interacting Protein 22
ZIZ31 2 3 5     Protein Zizimin 32
KIAA06941 3 5     Zizimin-33
DRIP22     Zizimin31
Nbla103002     Zizimin-33
Dedicator Of Cytokinesis Protein 102     

External Ids:    HGNC: 234791   Entrez Gene: 556192   Ensembl: ENSG000001359057   OMIM: 6115185   UniProtKB: Q96BY63   

Export aliases for DOCK10 gene to outside databases

Previous GC identifers: GC02M225832 GC02M225455 GC02M225338 GC02M217481


Summaries
for DOCK10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6
Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging
bound GDP for free GTP

Gene Wiki entry for DOCK10 (Dock10)


Genomic Views
for DOCK10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005403.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DOCK10 gene promoter:
         STAT1   Elk-1   STAT1beta   STAT6   CUTL1   STAT1alpha   CREB   STAT2   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DOCK10 promoter sequence
   Search SABiosciences Chromatin IP Primers for DOCK10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.2   Ensembl cytogenetic band:  2q36.2   HGNC cytogenetic band: 2q36.3

DOCK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M225593:  view genomic region     (about GC identifiers)

Start:
 225,629,807 bp from pter      End:
 225,907,330 bp from pter
Size:
 277,524 bases      Orientation:
 minus strand

Proteins
for DOCK10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 10  
Size: 2186 amino acids; 249531 Da
Sequence caution: Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA91022.1;
Type=Frameshift; Positions=2133; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
Secondary accessions: O75178 Q9NW06 Q9NXI8
Alternative splicing: 2 isoforms:  Q96BY6-1   Q96BY6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK10: NX_Q96BY6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BY6

    • DOCK10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055504.2  
    ENSEMBL proteins: 
     ENSP00000386392   ENSP00000386694   ENSP00000258390   ENSP00000437947   ENSP00000395178  
     ENSP00000394552   ENSP00000397389  
    Reactome Protein details: Q96BY6
    Human Recombinant Protein Products: 
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    Uscn Proteins for DOCK10


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    Uscn ELISAs and CLIAs for DOCK10

    Protein Domains /
    Families
    for DOCK10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DOCK10 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR021816 DOCK_C/D_N
     IPR027007 DOCK-C2
     IPR026791 DOCK
     IPR001849 Pleckstrin_homology
     IPR026796 DOCK_D

    Graphical View of Domain Structure for InterPro Entry Q96BY6

    ProtoNet protein and cluster: Q96BY6

    2 Blocks protein families:
    IPB001849 Pleckstrin-like
    IPB010703 Dedicator of cytokinesis


    UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6
    Domain: The DHR-2 domain may mediate some GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 PH domain


    Function
    for DOCK10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6
    Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging
    bound GDP for free GTP

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK10:
    hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence
    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DOCK10

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DOCK10 (see all 2)
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    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005525GTP binding ----
    GO:0005543phospholipid binding IEA--
    GO:0017048Rho GTPase binding IEA--


    DOCK10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DOCK10:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for DOCK10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Factors involved in megakaryocyte development and platelet production
    		Factors involved in megakaryocyte development and platelet production1.00
    2Regulation of CDC42 activity
    		Regulation of CDC42 activity1.00
    3Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for DOCK10 
        Regulation of CDC42 activity

    2        Reactome Pathways for DOCK10
        Hemostasis
    Factors involved in megakaryocyte development and platelet production



    DOCK10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DOCK10

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DOCK10 (Q96BY63 ENSP000002583904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOJQ9H4E53, ENSP000003167294I2D: score=1 STRING: ENSP00000316729
    LURAP1Q96LR23, ENSP000003610484I2D: score=3 STRING: ENSP00000361048
    CDC42ENSP000003144584STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--


    DOCK10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DOCK10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DOCK10

    3 HMDB Compounds for DOCK10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    Search CenterWatch for drugs/clinical trials and news about DOCK10 / DOC10 

    Transcripts
    for DOCK10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DOCK10 gene (2 alternative transcripts): 
    NM_017718.1  NM_014689.2  

    Unigene Cluster for DOCK10:

    Dedicator of cytokinesis 10
    Hs.46578  [show with all ESTs]
    Unigene Representative Sequence: NM_014689
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409802 ENST00000409592(uc002vob.2) ENST00000258390(uc002voa.2 uc002voc.2 uc010fwz.1)
    ENST00000535663 ENST00000492251 ENST00000422684 ENST00000489831 ENST00000472652
    ENST00000492369(uc002vod.1) ENST00000543715 ENST00000471810 ENST00000474102
    ENST00000435582 ENST00000458608

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate DOCK10:
    hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmid: DOCK10 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DOCK10 (see all 3)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DOCK10
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DOCK10 (NM_014689)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DOCK10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DOCK10

    Additional cDNA sequence: 

    AB014594.2 AB074179.1 AF250396.1 AK000227.1 AK001253.1 AK130257.1 AK293847.1 AK293879.1 
    AK307914.1 BC015018.1 CR749492.1 EU236710.2 

    13 DOTS entries:

    DT.313890  DT.101978788  DT.91723314  DT.92035575  DT.100010125  DT.120985656  DT.120985681  DT.91981816 
    DT.120942277  DT.100717776  DT.40130726  DT.95368908  DT.95368909 

    1 AceView cDNA sequence:

    BX493605 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                          -                                                               
    SP2:                                                                                                                                -         
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for DOCK10

    Expression
    for DOCK10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DOCK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAATTCCAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DOCK10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    KidneyRenal VesicleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See DOCK10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DOCK10

    SOURCE GeneReport for Unigene cluster: Hs.46578

    UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6
    Tissue specificity: Expressed at low level in brain and lung

        SABiosciences Custom PCR Arrays for DOCK10
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

    Orthologs
    for DOCK10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DOCK10 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DOCK101 dedicator of cytokinesis 10 78.43(n)
    82.88(a)    		   424803  XM_001234659.2  XP_001234660.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DOCK106
    		 --
    		 81(a)
    		 1 ↔ 1
    		 3(24531326-24643059)
    zebrafish
    (Danio rerio)    		 Actinopterygii dock101 dedicator of cytokinesis 10 67.36(n)
    70.24(a)    		   100000949  XM_001341012.4  XP_001341048.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG425336
    		 --
    		 33(a)
    		 1 → many
    		 2L(7472513-7496307)
    worm
    (Caenorhabditis elegans)    		 Secernentea F22G12.56
    		 --
    		 21(a)
    		 possible ortholog
    		 I(13162488-13182797)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SPK16
    		 guanyl-nucleotide exchange factor / GTPase binding...
    		 19(a)
    		 1 → many
    		 4(9228185-9241317)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 guanine nucleotide exchange factor, putative, expr...
    		 22(a)
    		 1 → many
    		 3(12000006-12006559)


    ENSEMBL Gene Tree for DOCK10 (if available)
    TreeFam Gene Tree for DOCK10 (if available) 

    Paralogs
    for DOCK10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DOCK10 gene
    DOCK92  DOCK72  DOCK112  DOCK62  DOCK82  
    10 SIMAP similar genes for DOCK10 using alignment to 7 protein entries:     DOC10_HUMAN (see all proteins):
    Nbla10300    DKFZp781A1532    DOCK10.2    DRIP2    DKFZp686N04132    DOCK11
    DOCK9    DOCK7    DOCK6    DOCK8

    DOCK10 for paralogs           About GeneDecksing



    Genomic Variants
    for DOCK10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4668 NCBI SNPs in DOCK10 are shown (see all 4668)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1931610111,2
    		--225629307(+) GTACTA/GAGGCT 1 -- ds50010--------
    rs75576571,2
    		C,A--225629474(+) gtcacA/Gtggtc 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs75842021,2
    		A--225629507(+) ggaaaC/Gtgcaa 1 -- ds50010--------
    rs1843513061,2
    		--225629576(+) ACAGAC/TCTCAA 1 -- ds50010--------
    rs743334891,2
    		C,--225629643(+) ACCTCT/CGATCT 1 -- ds50012Minor allele frequency- C:0.07CSA WA 120
    rs761854471,2
    		F,--225629687(+) AGATTT/AGAGTC 1 -- ds50011Minor allele frequency- A:0.05EA 120
    rs172714911,2
    		C,F,--225629713(+) GGCAAG/AGCATC 1 -- ds50016Minor allele frequency- A:0.03NA 266
    rs745483621,2
    		F,--225629788(+) CCCACT/GCTTCA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1441925771,2
    		--225630149(+) TGGGGC/TACTGA 1 -- ut310--------
    rs10456541,2
    		C,F,O,A,H,--225630233(-) AGCCAA/GGTTGA 1 -- ut31 ese331Minor allele frequency- G:0.27MN EA NA NS WA CSA 3157

    HapMap Linkage Disequilibrium report for DOCK10 (225629807 - 225879807 bp, first 250kb of DOCK10)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for DOCK10
         3 Indels: 42101 60349 26577

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    Disorders / Diseases
    for DOCK10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DOCK10 for disorders           About GeneDecksing

    OMIM gene information: 611518    OMIM disorders: --

    1 disease for DOCK10:    About MalaCards
    melanoma


    Export disorders for DOCK10 gene to outside databases

    Publications
    for DOCK10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DOCK10 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DOCK10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (2002)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
    8. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PubMed id 18499258)1, 9 Yelo E....Parrado A. (2008)
    9. Human and mouse DOCK10 splicing isoforms with alterna tive first coding exon usage are differentially expressed in T and B lymphocyte s. (PubMed id 21514340)1 Alcaraz-GarcA-a M.J....Parrado A. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for DOCK10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing DOCK10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55619 HGNC: 23479 AceView: DOCK10.2 Ensembl:ENSG00000135905 euGenes: HUgn55619
    ECgene: DOCK10 H-InvDB: DOCK10

    Other Databases showing DOCK10 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0694

    Specialized Databases showing DOCK10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DOCK10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DOCK10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DOCK10 gene:
    Search GeneIP for patents involving DOCK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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