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DOCK10 Gene

protein-coding   GIFtS: 57
GCID: GC02M225593

Dedicator Of Cytokinesis 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dedicator Of Cytokinesis 101 2     Nbla103002
ZIZ32 3 5     Dedicator Of Cytokinesis Protein 102
zizimin31 2     Dopamine Receptor Interacting Protein 22
KIAA06943 5     Zizimin-33
DRIP22     

External Ids:    HGNC: 234791   Entrez Gene: 556192   Ensembl: ENSG000001359057   OMIM: 6115185   UniProtKB: Q96BY63   

Export aliases for DOCK10 gene to outside databases

Previous GC identifers: GC02M225832 GC02M225455 GC02M225338 GC02M217481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOCK10 Gene:
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine
nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The
encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal
pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been
described. (provided by RefSeq, Mar 2014)

GeneCards Summary for DOCK10 Gene:
DOCK10 (dedicator of cytokinesis 10) is a protein-coding gene. Diseases associated with DOCK10 include attention deficit hyperactivity disorder, and melanoma. GO annotations related to this gene include Rho GTPase binding and phospholipid binding. An important paralog of this gene is DOCK9.

UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6
Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by
exchanging bound GDP for free GTP

Gene Wiki entry for DOCK10 (Dock10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOCK10 gene promoter:
         STAT1   Elk-1   STAT1beta   STAT6   CUTL1   STAT1alpha   CREB   STAT2   deltaCREB   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDOCK10 promoter sequence
   Search Chromatin IP Primers for DOCK10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.2   Ensembl cytogenetic band:  2q36.2   HGNC cytogenetic band: 2q36.3

DOCK10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M225593:  view genomic region     (about GC identifiers)

Start:
225,629,807 bp from pter      End:
225,907,330 bp from pter
Size:
277,524 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 10  
Size: 2186 amino acids; 249531 Da
Sequence caution: Sequence=AAH15018.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA31669.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA91022.1;
Type=Frameshift; Positions=2133; Sequence=BAA91583.1; Type=Erroneous initiation; Note=Translation N-terminally
extended;
Secondary accessions: B3FL70 O75178 Q9NW06 Q9NXI8
Alternative splicing: 3 isoforms:  Q96BY6-1   Q96BY6-2   Q96BY6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DOCK10: NX_Q96BY6

Explore proteomics data for DOCK10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOCK10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001277192.1  NP_055504.2  

    ENSEMBL proteins: 
     ENSP00000386694   ENSP00000258390   ENSP00000437947   ENSP00000395178   ENSP00000394552  
     ENSP00000397389  
    Reactome Protein details: Q96BY6

    DOCK10 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for DOCK10

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    Selected InterPro protein domains (see all 8):
     IPR021816 DOCK_C/D_N
     IPR027007 DHR-1_domain
     IPR026791 DOCK
     IPR001849 Pleckstrin_homology
     IPR026796 DOCK_D

    Graphical View of Domain Structure for InterPro Entry Q96BY6

    ProtoNet protein and cluster: Q96BY6

    2 Blocks protein domains:
    IPB001849 Pleckstrin-like
    IPB010703 Dedicator of cytokinesis


    UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6
    Domain: The DHR-2 domain may mediate some GEF activity (By similarity)
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 PH domain


    DOCK10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOC10_HUMAN, Q96BY6
    Function: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by
    exchanging bound GDP for free GTP
    Induction: Isoforms 1 and 2 are up-regulated in response to interleukin-4

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005085guanyl-nucleotide exchange factor activity ----
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005488binding ----
    GO:0017048Rho GTPase binding IEA--
         
    DOCK10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DOCK10:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOCK10
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOCK10

    miRNA
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    miRTarBase miRNAs that target DOCK10:
    hsa-mir-142-3p (MIRT021604), hsa-mir-21-5p (MIRT030887), hsa-mir-132-3p (MIRT021826), hsa-mir-26b-5p (MIRT029588)

    Block miRNA regulation of human, mouse, rat DOCK10 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DOCK10:
    hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidDOCK10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DOCK10
    Predesigned siRNA for gene silencing in human, mouse, rat DOCK10

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK10

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DOCK10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070062extracellular vesicular exosome IDA--

    DOCK10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOCK10 About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Regulation of CDC42 activity
    Regulation of CDC42 activity
    3Factors involved in megakaryocyte development and platelet production
    Factors involved in megakaryocyte development and platelet production

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DOCK10
        Regulation of CDC42 activity

    1 Reactome Pathway for DOCK10
        Factors involved in megakaryocyte development and platelet production



    DOCK10 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOCK10
    Interactions:

        Search GeneGlobe Interaction Network for DOCK10

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for DOCK10 (Q96BY63 ENSP000002583904) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOJQ9H4E53, ENSP000003167294I2D: score=1 STRING: ENSP00000316729
    LURAP1Q96LR23, ENSP000003610484I2D: score=3 STRING: ENSP00000361048
    CDC42ENSP000003144584STRING: ENSP00000314458
    NCKAP1ENSP000003542514STRING: ENSP00000354251
    NCKAP1LENSP000002933734STRING: ENSP00000293373
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0030334regulation of cell migration IDA18835169

    DOCK10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOCK10 (DOC10)

    3 HMDB Compounds for DOCK10    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DOCK10 gene (3 alternative transcripts): 
    NM_001290263.1  NM_014689.2  NM_017718.1  

    Unigene Cluster for DOCK10:

    Dedicator of cytokinesis 10
    Hs.46578  [show with all ESTs]
    Unigene Representative Sequence: NM_014689
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409592(uc002vob.2) ENST00000258390(uc002voa.2 uc002voc.2 uc010fwz.1)
    ENST00000535663 ENST00000492251 ENST00000422684 ENST00000489831 ENST00000472652
    ENST00000492369(uc002vod.1) ENST00000543715 ENST00000471810 ENST00000474102
    ENST00000435582 ENST00000458608
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DOCK10 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DOCK10:
    hsa-miR-203 hsa-miR-548d-3p hsa-miR-466 hsa-miR-19b hsa-miR-889 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidDOCK10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DOCK10
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    GenScript: all cDNA clones in your preferred vector: DOCK10 (NM_014689)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DOCK10
      QuantiFast Probe-based Assays in human, mouse, rat DOCK10

    Additional mRNA sequence: 

    AB014594.2 AB074179.1 AF250396.1 AK000227.1 AK001253.1 AK130257.1 AK293847.1 AK293879.1 
    AK307914.1 BC015018.1 CR749492.1 EU236710.2 

    13 DOTS entries:

    DT.313890  DT.101978788  DT.91723314  DT.92035575  DT.100010125  DT.120985656  DT.120985681  DT.91981816 
    DT.120942277  DT.100717776  DT.40130726  DT.95368908  DT.95368909 

    1 AceView cDNA sequence:

    BX493605 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
    SP1:                                                                          -                                                               
    SP2:                                                                                                                                -         
    SP3:                                                                                                                                          


    ECgene alternative splicing isoforms for DOCK10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOCK10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTCCAGT
    DOCK10 Expression
    About this image


    DOCK10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    DOCK10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOCK10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46578

    UniProtKB/Swiss-Prot: DOC10_HUMAN, Q96BY6
    Tissue specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3
    is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DOCK10 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock101 , 5 dedicator of cytokinesis 101, 5 87.44(n)1
    93.78(a)1
      1 (41.41 cM)5
    2102931  NM_175291.41  NP_780500.21 
     805010735 
    chicken
    (Gallus gallus)
    Aves DOCK101 dedicator of cytokinesis 10 78.37(n)
    82.75(a)
      424803  XM_001234659.3  XP_001234660.2 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK106
    dedicator of cytokinesis 10
    81(a)
    1 ↔ 1
    3(24454172-24644014)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dock101 dedicator of cytokinesis 10 71.93(n)
    74.5(a)
      100127561  XM_002937096.2  XP_002937142.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dock101 dedicator of cytokinesis 10 67.16(n)
    69.77(a)
      100000949  XM_001341012.5  XP_001341048.5 


    ENSEMBL Gene Tree for DOCK10 (if available)
    TreeFam Gene Tree for DOCK10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOCK10 gene
    DOCK92  DOCK72  DOCK112  DOCK62  DOCK82  
    9 SIMAP similar genes for DOCK10 using alignment to 6 protein entries:     DOC10_HUMAN (see all proteins):
    Nbla10300    DKFZp781A1532    DRIP2    DKFZp686N04132    DOCK11    DOCK9
    DOCK7    DOCK6    DOCK8

    DOCK10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOCK10 (see all 5624)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58390801,2
    C--225173173(+) AAAAA-/ACTCTT 1 -- int1 trp30--------
    rs1931610111,2
    --225629307(+) GTACTA/GAGGCT 1 -- ds50010--------
    rs75576571,2
    C,A--225629474(+) gtcacA/Gtggtc 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs75842021,2
    A--225629507(+) ggaaaC/Gtgcaa 1 -- ds50010--------
    rs1843513061,2
    --225629576(+) ACAGAC/TCTCAA 1 -- ds50010--------
    rs743334891,2
    C--225629643(+) ACCTCT/CGATCT 1 -- ds50012Minor allele frequency- C:0.07CSA WA 120
    rs761854471,2
    F--225629687(+) AGATTT/AGAGTC 1 -- ds50011Minor allele frequency- A:0.05EA 120
    rs172714911,2
    C,F--225629713(+) GGCAAG/AGCATC 1 -- ds50016Minor allele frequency- A:0.03NA 266
    rs745483621,2
    F--225629788(+) CCCACT/GCTTCA 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1441925771,2
    C--225630149(+) TGGGGC/TACTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DOCK10 (225629807 - 225879807 bp, first 250kb of DOCK10)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DOCK10 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721534CNV Deletion23290073
    esv1631002CNV Deletion17803354
    esv2668530CNV Deletion23128226
    esv2663234CNV Deletion23128226
    esv2721535CNV Deletion23290073
    esv4249CNV Deletion18987735
    dgv674e201CNV Deletion23290073
    esv268262CNV Insertion20981092
    esv274230CNV Insertion20981092
    esv1010048CNV Insertion20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611518    OMIM disorders: --

    2 diseases for DOCK10:    
    About MalaCards
    attention deficit hyperactivity disorder    melanoma


    DOCK10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DOCK10

    Export disorders for DOCK10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOCK10 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with DOCK10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2, 3 Cote J.-F. and Vuori K. (J. Cell Sci. 2002)
    2. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. (PubMed id 21514340)1, 2 Alcaraz-Garcia M.J.... Parrado A. (Hum. Immunol. 2011)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    9. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. (PubMed id 18499258)1, 9 Yelo E....Parrado A. (Mol. Immunol. 2008)
    10. A genome-wide association study of total serum and mite-specific IgEs in asthma patients. (PubMed id 23967269)1 Kim J.H....Shin H.D. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 55619 HGNC: 23479 AceView: DOCK10.2 Ensembl:ENSG00000135905 euGenes: HUgn55619
    ECgene: DOCK10 H-InvDB: DOCK10

    (According to HUGE)
    About This Section

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    HUGE: KIAA0694

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DOCK10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DOCK10 gene:
    Search GeneIP for patents involving DOCK10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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