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Aliases for DOCK1 Gene

Aliases for DOCK1 Gene

  • Dedicator Of Cytokinesis 1 2 3 5
  • 180 KDa Protein Downstream Of CRK 3 4
  • DOwnstream Of CrK 2 3
  • DOCK180 3 4
  • Dedicator Of Cytokinesis Protein 1 3
  • Dedicator Of Cyto-Kinesis 1 2
  • Ced5 3

External Ids for DOCK1 Gene

Previous GeneCards Identifiers for DOCK1 Gene

  • GC10P127593
  • GC10P127797
  • GC10P128709
  • GC10P128168
  • GC10P128584
  • GC10P122340

Summaries for DOCK1 Gene

Entrez Gene Summary for DOCK1 Gene

  • This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for DOCK1 Gene

DOCK1 (Dedicator Of Cytokinesis 1) is a Protein Coding gene. Diseases associated with DOCK1 include Distal 10Q Deletion Syndrome. Among its related pathways are Platelet activation, signaling and aggregation and Shigellosis. GO annotations related to this gene include binding and heme binding. An important paralog of this gene is DOCK5.

UniProtKB/Swiss-Prot for DOCK1 Gene

  • Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).

Gene Wiki entry for DOCK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK1 Gene

Genomics for DOCK1 Gene

Regulatory Elements for DOCK1 Gene

Enhancers for DOCK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DOCK1 on UCSC Golden Path with GeneCards custom track

Promoters for DOCK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DOCK1 Gene

Chromosome:
10
Start:
126,905,409 bp from pter
End:
127,452,517 bp from pter
Size:
547,109 bases
Orientation:
Plus strand

Genomic View for DOCK1 Gene

Genes around DOCK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK1 Gene

Proteins for DOCK1 Gene

  • Protein details for DOCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14185-DOCK1_HUMAN
    Recommended name:
    Dedicator of cytokinesis protein 1
    Protein Accession:
    Q14185
    Secondary Accessions:
    • A9Z1Z5

    Protein attributes for DOCK1 Gene

    Size:
    1865 amino acids
    Molecular mass:
    215346 Da
    Quaternary structure:
    • Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1.

    Three dimensional structures from OCA and Proteopedia for DOCK1 Gene

neXtProt entry for DOCK1 Gene

Post-translational modifications for DOCK1 Gene

  • Ubiquitination at Lys 799
  • Modification sites at PhosphoSitePlus

Other Protein References for DOCK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DOCK1 (DOCK1)
  • Cloud-Clone Corp. Antibodies for DOCK1

No data available for DME Specific Peptides for DOCK1 Gene

Domains & Families for DOCK1 Gene

Suggested Antigen Peptide Sequences for DOCK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14185

UniProtKB/Swiss-Prot:

DOCK1_HUMAN :
  • The DHR-2 domain is necessary and sufficient for the GEF activity.
  • Belongs to the DOCK family.
Domain:
  • The DHR-2 domain is necessary and sufficient for the GEF activity.
  • Contains 1 DHR-1 domain.
  • Contains 1 DHR-2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK1: view

No data available for Gene Families for DOCK1 Gene

Function for DOCK1 Gene

Molecular function for DOCK1 Gene

GENATLAS Biochemistry:
Crk-binding protein 180 kDa
UniProtKB/Swiss-Prot Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).

Gene Ontology (GO) - Molecular Function for DOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 contributes_to guanyl-nucleotide exchange factor activity IDA 12134158
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA,IPI 12134158
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with DOCK1: view
genes like me logo Genes that share phenotypes with DOCK1: view

Animal Models for DOCK1 Gene

MGI Knock Outs for DOCK1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOCK1 Gene

Localization for DOCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK1 Gene

Cytoplasm. Membrane. Note=Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000305}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOCK1 Gene COMPARTMENTS Subcellular localization image for DOCK1 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DOCK1: view

Pathways & Interactions for DOCK1 Gene

genes like me logo Genes that share pathways with DOCK1: view

Gene Ontology (GO) - Biological Process for DOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006911 phagocytosis, engulfment TAS 9548255
GO:0006915 apoptotic process IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007165 signal transduction TAS 8661160
GO:0007229 integrin-mediated signaling pathway TAS 9808620
genes like me logo Genes that share ontologies with DOCK1: view

No data available for SIGNOR curated interactions for DOCK1 Gene

Drugs & Compounds for DOCK1 Gene

(4) Drugs for DOCK1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK1: view

Transcripts for DOCK1 Gene

Unigene Clusters for DOCK1 Gene

Dedicator of cytokinesis 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

ExUns: 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44a · 44b ^ 45a · 45b ^ 46 ^
SP1: - - - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:

ExUns: 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52a · 52b ^ 53 ^ 54 ^ 55
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for DOCK1 Gene

GeneLoc Exon Structure for
DOCK1
ECgene alternative splicing isoforms for
DOCK1

Expression for DOCK1 Gene

mRNA expression in normal human tissues for DOCK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DOCK1 Gene

This gene is overexpressed in Salivary gland (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DOCK1 Gene



Protein tissue co-expression partners for DOCK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DOCK1 Gene:

DOCK1

SOURCE GeneReport for Unigene cluster for DOCK1 Gene:

Hs.159195

mRNA Expression by UniProt/SwissProt for DOCK1 Gene:

Q14185-DOCK1_HUMAN
Tissue specificity: Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
genes like me logo Genes that share expression patterns with DOCK1: view

Primer Products

No data available for mRNA differential expression in normal tissues for DOCK1 Gene

Orthologs for DOCK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOCK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOCK1 34
  • 89.83 (n)
  • 97.69 (a)
DOCK1 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOCK1 34
  • 91.26 (n)
  • 98.05 (a)
DOCK1 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dock1 34
  • 87.56 (n)
  • 96.51 (a)
Dock1 16
Dock1 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dock1 34
  • 87.48 (n)
  • 96.46 (a)
oppossum
(Monodelphis domestica)
Mammalia DOCK1 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOCK1 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DOCK1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOCK1 34
  • 82.23 (n)
  • 94.58 (a)
DOCK1 35
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOCK1 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dock1 34
  • 76.25 (n)
  • 86.98 (a)
Str.17267 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.18189 34
zebrafish
(Danio rerio)
Actinopterygii dock1 34
  • 75.36 (n)
  • 84.57 (a)
dock1 35
  • 83 (a)
OneToMany
DOCK1 (1 of 3) 35
  • 86 (a)
OneToMany
DOCK1 (2 of 3) 35
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mbc 36
  • 39 (a)
mbc 34
  • 51.87 (n)
  • 44.9 (a)
mbc 35
  • 38 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004320 34
  • 53.18 (n)
  • 46.93 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-5 34
  • 44.93 (n)
  • 32.32 (a)
ced-5 35
  • 28 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 54 (a)
OneToMany
Species where no ortholog for DOCK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOCK1 Gene

ENSEMBL:
Gene Tree for DOCK1 (if available)
TreeFam:
Gene Tree for DOCK1 (if available)

Paralogs for DOCK1 Gene

Paralogs for DOCK1 Gene

(6) SIMAP similar genes for DOCK1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DOCK1 Gene

genes like me logo Genes that share paralogs with DOCK1: view

Variants for DOCK1 Gene

Sequence variations from dbSNP and Humsavar for DOCK1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs869801 - 127,447,420(+) CGGGG(A/G)CGGAC reference, missense
rs1926426 -- 127,334,034(-) AAAAT(A/G)TTAAA intron-variant
rs1926427 -- 127,439,308(-) CCCAC(C/T)GTCAG intron-variant
rs1926428 -- 127,284,704(-) CATGA(A/T)AATAC intron-variant
rs1926429 -- 127,419,304(-) TACAC(C/T)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK1 Gene

Variant ID Type Subtype PubMed ID
dgv1418n54 CNV loss 21841781
dgv1419n54 CNV loss 21841781
dgv1420n54 CNV loss 21841781
dgv1421n54 CNV loss 21841781
dgv301e212 CNV loss 25503493
dgv302e212 CNV loss 25503493
esv1034103 CNV insertion 17803354
esv21647 CNV gain 19812545
esv2282957 CNV deletion 18987734
esv2392532 CNV deletion 18987734
esv24572 CNV gain 19812545
esv2497278 CNV insertion 19546169
esv2652779 CNV insertion 19546169
esv2660205 CNV deletion 23128226
esv2668745 CNV deletion 23128226
esv2672304 CNV deletion 23128226
esv2674826 CNV deletion 23128226
esv2675716 CNV deletion 23128226
esv2676964 CNV deletion 23128226
esv27067 CNV gain+loss 19812545
esv2759789 CNV gain 17122850
esv2764113 CNV gain 21179565
esv28929 CNV loss 19812545
esv3144388 CNV deletion 24192839
esv3306875 CNV mobile element insertion 20981092
esv3356897 CNV insertion 20981092
esv3366806 CNV insertion 20981092
esv3412818 CNV duplication 20981092
esv3427763 CNV insertion 20981092
esv3547015 CNV deletion 23714750
esv3547020 CNV deletion 23714750
esv3547026 CNV deletion 23714750
esv3624868 CNV loss 21293372
esv3624869 CNV gain 21293372
esv3624870 CNV gain 21293372
esv3624871 CNV gain 21293372
esv3624873 CNV loss 21293372
esv3624874 CNV loss 21293372
esv3624875 CNV loss 21293372
esv3624878 CNV gain 21293372
esv3624879 CNV loss 21293372
esv3624881 CNV loss 21293372
esv3624882 CNV loss 21293372
esv3624883 CNV loss 21293372
esv3891896 CNV gain 25118596
esv3891897 CNV loss 25118596
esv5112 CNV loss 18987735
nsv1045065 CNV gain 25217958
nsv1045509 CNV gain 25217958
nsv1049693 CNV gain 25217958
nsv1069089 CNV deletion 25765185
nsv1076368 CNV duplication 25765185
nsv1110182 CNV duplication 24896259
nsv1113344 CNV deletion 24896259
nsv1113345 CNV deletion 24896259
nsv1116661 CNV tandem duplication 24896259
nsv1122565 CNV deletion 24896259
nsv1140278 OTHER inversion 24896259
nsv1140458 CNV tandem duplication 24896259
nsv1147260 CNV insertion 26484159
nsv1150633 CNV duplication 26484159
nsv1153179 CNV insertion 26484159
nsv1159781 CNV duplication 26073780
nsv25417 CNV insertion 16902084
nsv471891 CNV novel sequence insertion 20440878
nsv473586 CNV novel sequence insertion 20440878
nsv474053 CNV novel sequence insertion 20440878
nsv474057 CNV novel sequence insertion 20440878
nsv475379 CNV novel sequence insertion 20440878
nsv475859 CNV novel sequence insertion 20440878
nsv475923 CNV novel sequence insertion 20440878
nsv477772 CNV novel sequence insertion 20440878
nsv479096 CNV novel sequence insertion 20440878
nsv479274 CNV novel sequence insertion 20440878
nsv479797 CNV novel sequence insertion 20440878
nsv480021 CNV novel sequence insertion 20440878
nsv480230 CNV novel sequence insertion 20440878
nsv480635 CNV novel sequence insertion 20440878
nsv480655 CNV novel sequence insertion 20440878
nsv480966 CNV novel sequence insertion 20440878
nsv481283 CNV novel sequence insertion 20440878
nsv481335 CNV novel sequence insertion 20440878
nsv481458 CNV novel sequence insertion 20440878
nsv511443 CNV gain 21212237
nsv515706 CNV gain+loss 19592680
nsv519173 CNV loss 19592680
nsv526580 CNV loss 19592680
nsv552298 CNV loss 21841781
nsv552301 CNV loss 21841781
nsv7605 CNV insertion 18451855
nsv821275 CNV deletion 20802225
nsv832018 CNV gain 17160897
nsv832019 CNV loss 17160897
nsv8740 CNV gain 18304495
nsv8741 CNV loss 18304495
nsv951874 CNV deletion 24416366

Variation tolerance for DOCK1 Gene

Gene Damage Index Score: 3.97; 59.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DOCK1 Gene

Human Gene Mutation Database (HGMD)
DOCK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOCK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK1 Gene

Disorders for DOCK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DOCK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
distal 10q deletion syndrome
  • chromosome 10q26 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DOCK1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DOCK1

Genetic Association Database (GAD)
DOCK1
Human Genome Epidemiology (HuGE) Navigator
DOCK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DOCK1
genes like me logo Genes that share disorders with DOCK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOCK1 Gene

Publications for DOCK1 Gene

  1. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. (PMID: 8657152) Hasegawa H. … Matsuda M. (Mol. Cell. Biol. 1996) 2 3 4 22 65
  2. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders M.A. … Basson M.D. (J. Biol. Chem. 2009) 3 4 22 65
  3. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. (PMID: 9808620) Kiyokawa E. … Matsuda M. (Genes Dev. 1998) 3 4 22 65
  4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 65
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 65

Products for DOCK1 Gene

Sources for DOCK1 Gene

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