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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DOCK1 Gene

protein-coding GIFtS: 66
GCID: GC10P128584

dedicator of cytokinesis 1

(Previous name: dedicator of cyto-kinesis 1 )

Explore 7 diseases affiliated with
DOCK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dedicator Of Cytokinesis 1¹ ²		180 KDa Protein Downstream Of CRK² ³
DOCK180¹ ² ³ ⁵		Dedicator Of Cytokinesis Protein 1²
Ced5¹		DOwnstream Of CrK²
Dedicator Of Cyto-Kinesis 1¹ ²

External Ids:	HGNC: 2987¹	Entrez Gene: 1793²	Ensembl: ENSG00000150760⁷	OMIM: 601403⁵	UniProtKB: Q14185³

Export aliases for DOCK1 gene to outside databases

Previous GC identifers: GC10P127593 GC10P127797 GC10P128709 GC10P128168 GC10P122340

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DOCK1:

This gene product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in

the cell surface extension of an engulfing cell around a dying cell during apoptosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185

Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP

for free GTP. Its GEF activity may be enhanced by ELMO1

Gene Wiki entry for DOCK1 (Dock180)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008818.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DOCK1 gene promoter:
E2F-4 E2F-3a E2F-5 FOXO3 POU6F1 (c2) E2F-2 PPAR-alpha FAC1 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DOCK1 promoter sequence

Search SABiosciences Chromatin IP Primers for DOCK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DOCK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13-q26.3 Ensembl cytogenetic band: 10q26.2 HGNC cytogenetic band: 10q26.13-q26.3

DOCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P128584: view genomic region (about GC identifiers)

Start:	128,593,978 bp from pter	End:	129,250,781 bp from pter
Size:	656,804 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185 (See protein sequence)

Recommended Name: Dedicator of cytokinesis protein 1

Size: 1865 amino acids; 215346 Da

Subunit: Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its

DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1

Subcellular location: Cytoplasm (Probable). Membrane (Probable). Note=Recruited to membranes via its interaction with

phosphatidylinositol 3,4,5-trisphosphate (Probable)

1 PDB 3D structure from and Proteopedia for DOCK1:

3L4C (3D)

Secondary accessions: A9Z1Z5

Explore the universe of human proteins at neXtProt for DOCK1: NX_Q14185

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14185

DOCK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001371.1

ENSEMBL proteins:

ENSP00000280333

Reactome Protein details: Q14185
Human Recombinant Protein Products:

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	Uscn Proteins for DOCK1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	TAS	8661160
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	IEA	--

DOCK1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DOCK1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DOCK1 for domains About GeneDecksing

5 InterPro domains/families:

IPR027007 DOCK-C2

IPR026791 DOCK

IPR026799 DOCK_A

IPR001452 SH3_domain

IPR010703 DOCK_C

Graphical View of Domain Structure for InterPro Entry Q14185

ProtoNet protein and cluster: Q14185

2 Blocks protein families:

IPB001452 SH3 domain signature

IPB010703 Dedicator of cytokinesis

UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185

Domain: The DHR-2 domain is necessary and sufficient for the GEF activity

Similarity: Belongs to the DOCK family

Similarity: Contains 1 DHR-1 domain

Similarity: Contains 1 DHR-2 domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185

Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP

for free GTP. Its GEF activity may be enhanced by ELMO1

Genatlas biochemistry entry for DOCK1:

Crk-binding protein 180 kDa

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		hsa-miR-579 hsa-miR-31 hsa-miR-154 hsa-miR-520d-5p hsa-miR-539 hsa-miR-4263 hsa-miR-1271 hsa-let-7a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: DOCK1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005096	GTPase activator activity	TAS	9808620
GO:0005515	protein binding	IPI	--
GO:0005525	GTP binding	--	--
GO:0017124	SH3 domain binding	IEA	--

DOCK1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DOCK1:

Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Dock1^tm1Jfco for DOCK1
8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dock1):

cardiovascular system	cellular	embryogenesis	growth/size	homeostasis/metabolism
mortality/aging	muscle	respiratory system

DOCK1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66			HGF Pathway	0.24

Development FGFR signaling pathway

Development FGFR signaling pathway

1.00

Development_FGFR signaling pathway

0.98

Immune System

Immune System

1.00

Innate Immune System

0.46

Netrin-1 signaling

Netrin-1 signaling

1.00

DCC mediated attractive signaling

0.33

Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation

1.00

Fcgamma receptor (FCGR) dependent phagocytosis

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for DOCK1

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling FAK signaling
	Development FGFR signaling pathway

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DOCK1

	HGF Pathway
	ILK Signaling
	Paxillin Interactions
	Integrin Pathway
	FAK1 Signaling

2 Cell Signaling Technology (CST) Pathways for DOCK1

	Tyrosine Kinases / Adaptors
	Adhesion

3 GeneGo (Thomson Reuters) Pathways for DOCK1

	Cell adhesion Integrin-mediated cell adhesion and migration
	Development FGFR signaling pathway
	Cytoskeleton remodeling FAK signaling

5/9 BioSystems Pathways for DOCK1 (see all 9)

	Integrin-mediated cell adhesion
	Focal Adhesion
	Regulation of Actin Cytoskeleton
	Regulation of RAC1 activity
	Neurotrophic factor-mediated Trk receptor signaling

5/10 Reactome Pathways for DOCK1 (see all 10)

	Hemostasis
	Developmental Biology
	Fcgamma receptor (FCGR) dependent phagocytosis
	Netrin-1 signaling
	Factors involved in megakaryocyte development and platelet production

4 Kegg Pathways (Kegg details for DOCK1):

	Focal adhesion
	Regulation of actin cytoskeleton
	Bacterial invasion of epithelial cells
	Shigellosis

DOCK1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DOCK1

5/586 Interacting proteins for DOCK1 (Q14185^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 586)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELMO1	Q92556¹^,²^,³	EBI-446740,EBI-346417 MINT-7304529 MINT-7305878 MINT-7304644 MINT-7304545 MINT-7306029 MINT-7304464 MINT-7304751 MINT-7304491 MINT-7304698 MINT-7304510 MINT-7304722 MINT-50367 MINT-7305904 I2D: score=8
RAC1	P63000¹^,²^,³	EBI-446740,EBI-413628 MINT-7306029 MINT-7305963 I2D: score=6
ANKRD28	O15084²^,³	MINT-7231973 MINT-7232107 MINT-7231945 MINT-7232187 I2D: score=1
NCK2	O43639²^,³	MINT-14291 MINT-14292 MINT-14290 I2D: score=4
GRB2	P62993¹^,³	EBI-446740,EBI-401755 I2D: score=4

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006911	phagocytosis, engulfment	TAS	9548255
GO:0006915	apoptotic process	IEA	--
GO:0007165	signal transduction	TAS	8661160
GO:0007229	integrin-mediated signaling pathway	TAS	9808620
GO:0007264	small GTPase mediated signal transduction	IEA	--

DOCK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DOCK1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DOCK1

3 HMDB Compounds for DOCK1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 Novoseek chemical compound relationship for DOCK1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	21.5	5	19458477 (1), 8657152 (1), 9622053 (1), 19118547 (1)

Search CenterWatch for drugs/clinical trials and news about DOCK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DOCK1 gene:

NM_001380.3

Unigene Cluster for DOCK1:

Dedicator of cytokinesis 1

Hs.159195 [show with all ESTs]

Unigene Representative Sequence: NM_001380

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000280333(uc001ljt.3 uc010qun.2 uc009yaq.3) ENST00000473861

ENST00000484400 ENST00000495574 ENST00000464466

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		hsa-miR-579 hsa-miR-31 hsa-miR-154 hsa-miR-520d-5p hsa-miR-539 hsa-miR-4263 hsa-miR-1271 hsa-let-7a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: DOCK1 3' UTR sequence

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Additional cDNA sequence:

AK000789.1 AK091673.1 BC144632.1 BC146857.1 BX648342.1 D50857.1

11 DOTS entries:

DT.315942 DT.101981392 DT.95235099 DT.40304609 DT.40226218 DT.91862097 DT.75157657 DT.100821267

DT.75106797 DT.75147184 DT.95197213

24/164 AceView cDNA sequences (see all 164):

BX504728 BF062564 BQ009189 AW139803 BI255996 BU556771 CD644252 BU618781

BQ029988 CB136741 BM725394 AA359407 CB242120 AI951513 T83590 AW298149

AI206989 AK091673 AL138063 BX955686 CD104773 BI962522 BE546573 NM_001380

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DOCK1 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^
SP1:																											-						-
SP2:
SP3:
SP4:
SP5:

ExUns:	25	^	26a	·	26b	^	27a	·	27b	^	28	^	29	^	30	^	31	^	32	^	33	^	34	^	35	^	36	^	37	^	38	^	39	^	40	^	41	^	42	^	43	^	44a	·	44b	^	45a	·	45b	^	46	^
SP1:									-						-				-				-																				-						-
SP2:																			-				-																				-						-
SP3:															-				-
SP4:																							-
SP5:

ExUns:	47	^	48	^	49	^	50	^	51	^	52a	·	52b	^	53	^	54	^	55
SP1:													-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DOCK1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DOCK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATACTCTTCT

About this image

DOCK1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Mononuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Mononuclear Myocytes

Skeletal Muscle

Thoracic Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Primary Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Lumbar Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DOCK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DOCK1

SOURCE GeneReport for Unigene cluster: Hs.159195

UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185

Tissue specificity: Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in

thymus, testes and colon

SABiosciences Expression via Pathway-Focused PCR Array including DOCK1:

Focal Adhesions in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DOCK1 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DOCK1¹	dedicator of cytokinesis 1	81.91(n) 94.2(a)		423960 XM_421819.3 XP_421819.3
lizard (Anolis carolinensis)	Reptilia	DOCK1⁶	--	93(a)	1 ↔ 1	3(52979041-53435146)
African clawed frog (Xenopus laevis)	Amphibia	Xl.18189²	Xenopus laevis transcribed sequence with weak similarity more	75.6(n)		CB592685.1
zebrafish (Danio rerio)	Actinopterygii	dock1¹	dedicator of cytokinesis 1	75.41(n) 84.68(a)		572187 NM_001110011.1 NP_001103481.1
fruit fly (Drosophila melanogaster)	Insecta	mbc^{1 , 3}	larval visceral muscle development³ myoblast city¹	39(a)³ 50.64(n)¹ 43.45(a)¹		42817¹ NM_057796.3¹ NP_477144.1¹
worm (Caenorhabditis elegans)	Secernentea	ced-5¹	Protein CED-5	44.33(n) 31.82(a)		177942 NM_069537.4 NP_501938.1

ENSEMBL Gene Tree for DOCK1 (if available)
TreeFam Gene Tree for DOCK1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DOCK1 gene

DOCK3² DOCK4² DOCK2² DOCK5²

6 SIMAP similar genes for DOCK1 using alignment to 2 protein entries: DOCK1_HUMAN (see all proteins):

DKFZp779M164 DKFZp781J211 DOCK5 DOCK2 DOCK4 DOCK3

DOCK1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DOCK1
PGOHUM00000233544

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs67946709^1,2	C,	--	122397435(+)	`AAACA-/TTAAAC`	1	--	int¹		1		NA	2
rs34909727^1,2	C,	--	122403067(+)	`GATAA-/GGCACC`	1	--	int¹		1		NA	2
rs35938133^1,2	C	--	122491247(+)	`CCTCC-/TTTTTT`	1	--	int¹		1		NA	2
rs148844596^1,2		--	128766969(+)	`ATGCTC/GTTAGG`	1	--	int¹		0	--	--	--	--
rs145383149^1,2		--	128766987(+)	`ATAGAC/TGTATT`	1	--	int¹		0	--	--	--	--
rs80149447^1,2	C,F,	--	128767150(+)	`TCAGTT/CGAGGA`	1	--	int¹		3		WA NA EA	358
rs117668724^1,2	F,	--	128767271(+)	`GCAATG/ATGCTT`	1	--	int¹		1		EA	120
rs191021662^1,2		--	128767308(+)	`GTAGCA/GGTAGA`	1	--	int¹		0	--	--	--	--
rs113892749^1,2		--	128767319(+)	`CATCTC/TGATAG`	1	--	int¹		1		CSA	2
rs115784198^1,2	F,	--	128767362(+)	`TCACCG/ATTACC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for DOCK1 (128593978 - 128843978 bp, first 250kb of DOCK1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for DOCK1
6 CNVs: 3826 71135 30522 101071 2893 34862
8 Indels: 71137 101070 33529 42435 44682 44683 71136 65811

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DOCK1 for disorders           About GeneDecksing

OMIM gene information: 601403    OMIM disorders: --

7 diseases for DOCK1:    About MalaCards

amyotrophic lateral sclerosis lateral sclerosis shigellosis rabies

alzheimer's disease ovarian cancer asthma

1 Novoseek disease relationship for DOCK1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	17671188 (1)

Human Genome Epidemiology (HuGE) Navigator: DOCK1 (6 documents)

Export disorders for DOCK1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DOCK1 gene, integrated from 9 sources (see all 79):
(articles sorted by number of sources associating them with DOCK1)

Utopia: connect your pdf to the dynamic
world of online information

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. (PubMed id 8657152)^{1, 2, 3, 9} Hasegawa H.... Matsuda M. (1996)
Activation of Rac1 by a Crk SH3-binding protein, DOCK180. (PubMed id 9808620)^{1, 2, 9} Kiyokawa E....Matsuda M. (1998)
Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)^{1, 2} Cote J.-F. and Vuori K. (2002)
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. (PubMed id 12134158)^{1, 2} Brugnera E....Ravichandran K.S. (2002)
Identification and kinetic analysis of the interaction between Nck-2 and DOCK180. (PubMed id 11240126)^{1, 2} Tu Y.... Wu C. (2001)
Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3. (PubMed id 11171081)^{1, 2} Kobayashi S....Fukui Y. (2001)
Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. (PubMed id 8662907)^{1, 2} Matsuda M.... Kurata T. (1996)
Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ hybridization. (PubMed id 8661160)^{1, 3} Takai S....Matsuda M. (1996)
Elmo1 inhibits ubiquitylation of Dock180. (PubMed id 16495483)^{1, 9} Makino Y....Tanaka S. (2006)
Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation. (PubMed id 19118547)^{1, 9} Tachibana M....Matsuda M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1793	HGNC: 2987	AceView: DOCK1	Ensembl:ENSG00000150760	euGenes: HUgn1793
ECgene: DOCK1	Kegg: 1793	H-InvDB: DOCK1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DOCK1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DOCK1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DOCK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DOCK1 gene:
Search GeneIP for patents involving DOCK1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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