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DOCK1 Gene

protein-coding   GIFtS: 69
GCID: GC10P128584

Dedicator Of Cytokinesis 1

(Previous name: dedicator of cyto-kinesis 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dedicator Of Cytokinesis 11 2     Dedicator Of Cyto-Kinesis 11
DOCK1802 3 5     ced52
DOwnstream Of CrK1 2     Dedicator Of Cytokinesis Protein 12
180 KDa Protein Downstream Of CRK2 3     

External Ids:    HGNC: 29871   Entrez Gene: 17932   Ensembl: ENSG000001507607   OMIM: 6014035   UniProtKB: Q141853   

Export aliases for DOCK1 gene to outside databases

Previous GC identifers: GC10P127593 GC10P127797 GC10P128709 GC10P128168 GC10P122340


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DOCK1 Gene:
This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act
as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small
GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration.
Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for DOCK1 Gene:
DOCK1 (dedicator of cytokinesis 1) is a protein-coding gene. Diseases associated with DOCK1 include shigellosis, and rabies. GO annotations related to this gene include GTPase activator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK4.

UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185
Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.
Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging
bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1

Gene Wiki entry for DOCK1 (Dock180) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOCK1 gene promoter:
         E2F-4   E2F-3a   E2F-5   FOXO3   POU6F1 (c2)   E2F-2   PPAR-alpha   FAC1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DOCK1 promoter sequence
   Search Chromatin IP Primers for DOCK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOCK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13-q26.3   Ensembl cytogenetic band:  10q26.2   HGNC cytogenetic band: 10q26.13-q26.3

DOCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOCK1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P128584:  view genomic region     (about GC identifiers)

Start:
128,593,978 bp from pter      End:
129,250,781 bp from pter
Size:
656,804 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185 (See protein sequence)
Recommended Name: Dedicator of cytokinesis protein 1  
Size: 1865 amino acids; 215346 Da
Subunit: Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1
via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and
BAI1
1 PDB 3D structure from and Proteopedia for DOCK1:
3L4C (3D)    
Secondary accessions: A9Z1Z5

Explore the universe of human proteins at neXtProt for DOCK1: NX_Q14185

Explore proteomics data for DOCK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys799
  • Modification sites at PhosphoSitePlus

  • See DOCK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001277152.1  NP_001371.1  

    ENSEMBL proteins: 
     ENSP00000280333  
    Reactome Protein details: Q14185

    DOCK1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DOCK1

    DOCK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    DOCK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DOCK1
    Cloud-Clone Corp. CLIAs for DOCK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR027007 DHR-1_domain
     IPR026791 DOCK
     IPR001452 SH3_domain
     IPR027357 DHR-2
     IPR010703 DOCK_C

    Graphical View of Domain Structure for InterPro Entry Q14185

    ProtoNet protein and cluster: Q14185

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB010703 Dedicator of cytokinesis


    UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185
    Domain: The DHR-2 domain is necessary and sufficient for the GEF activity
    Similarity: Belongs to the DOCK family
    Similarity: Contains 1 DHR-1 domain
    Similarity: Contains 1 DHR-2 domain
    Similarity: Contains 1 SH3 domain


    DOCK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOCK1_HUMAN, Q14185
    Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility.
    Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging
    bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1

         Genatlas biochemistry entry for DOCK1:
    Crk-binding protein 180 kDa

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005096GTPase activator activity TAS9808620
    GO:0005488binding ----
    GO:0005515protein binding IPI12134158
    GO:0009055electron carrier activity ----
         
    DOCK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DOCK1:
     Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dock1):
     cardiovascular system  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  mortality/aging  muscle  no phenotypic analysis  respiratory system 
     tumorigenesis 

    DOCK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dock1tm1Jfco for DOCK1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOCK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOCK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOCK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOCK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DOCK1:
    hsa-mir-183-5p (MIRT047082), hsa-mir-296-3p (MIRT038422)

    Block miRNA regulation of human, mouse, rat DOCK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DOCK1 (see all 15):
    hsa-miR-579 hsa-miR-31 hsa-miR-154 hsa-miR-520d-5p hsa-miR-539 hsa-miR-4263 hsa-miR-1271 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidDOCK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DOCK1
    Predesigned siRNA for gene silencing in human, mouse, rat DOCK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DOCK1

    Clone
    Products:
         
    OriGene clones in human, mouse for DOCK1 (see all 5)
    OriGene ORF clones in mouse, rat for DOCK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOCK1 (NM_001380)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOCK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DOCK1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOCK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DOCK1_HUMAN, Q14185: Cytoplasm (Probable). Membrane (Probable). Note=Recruited to membranes via its interaction
    with phosphatidylinositol 3,4,5-trisphosphate (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    cytoskeleton2
    plasma membrane2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    DOCK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DOCK1 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    HGF Pathway0.34
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    4Integrin Pathway
    FAK1 Signaling0.67
    Integrin Pathway0.67
    5L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DOCK1
        HGF Pathway
    ILK Signaling
    Paxillin Interactions
    Integrin Pathway
    FAK1 Signaling

    2 Cell Signaling Technology (CST) Pathways for DOCK1
        Tyrosine Kinases / Adaptors
    Adhesion

    3 GeneGo (Thomson Reuters) Pathways for DOCK1
        Cell adhesion Integrin-mediated cell adhesion and migration
    Development FGFR signaling pathway
    Cytoskeleton remodeling FAK signaling

    Selected BioSystems Pathways for DOCK1 (see all 10)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Regulation of Actin Cytoskeleton
    Prostate Cancer
    Neurotrophic factor-mediated Trk receptor signaling

    3 Reactome Pathways for DOCK1
        Factors involved in megakaryocyte development and platelet production
    Regulation of actin dynamics for phagocytic cup formation
    DCC mediated attractive signaling


    4 Kegg Pathways  (Kegg details for DOCK1):
        Focal adhesion
    Regulation of actin cytoskeleton
    Bacterial invasion of epithelial cells
    Shigellosis


    DOCK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DOCK1: 
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DOCK1

    Selected Interacting proteins for DOCK1 (Q141851, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 613)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELMO1Q925561, 2, 3EBI-446740,EBI-346417 MINT-7304529 MINT-7305878 MINT-7304644 MINT-7304545 MINT-7306029 MINT-7304464 MINT-7304751 MINT-7304491 MINT-7304698 MINT-7304510 MINT-7304722 MINT-50367 MINT-7305904 I2D: score=8 
    ANKRD28O150841, 2, 3EBI-446740,EBI-359567 MINT-7231973 MINT-7232107 MINT-7231945 MINT-7232187 I2D: score=1 
    RAC1P630001, 2, 3EBI-446740,EBI-413628 MINT-7306029 MINT-7305963 I2D: score=6 
    NCK2O436392, 3MINT-14291 MINT-14292 MINT-14290 I2D: score=4 
    GRB2P629931, 3EBI-446740,EBI-401755 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006911phagocytosis, engulfment TAS9548255
    GO:0006915apoptotic process IEA--
    GO:0007165signal transduction TAS8661160
    GO:0007229integrin-mediated signaling pathway TAS9808620
    GO:0007264small GTPase mediated signal transduction IEA--

    DOCK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOCK1

    3 HMDB Compounds for DOCK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for DOCK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.5 5 19458477 (1), 8657152 (1), 9622053 (1), 19118547 (1)



    DOCK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DOCK1 gene (2 alternative transcripts): 
    NM_001290223.1  NM_001380.4  

    Unigene Cluster for DOCK1:

    Dedicator of cytokinesis 1
    Hs.159195  [show with all ESTs]
    Unigene Representative Sequence: NM_001380
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280333(uc001ljt.3 uc010qun.2 uc009yaq.3) ENST00000473861
    ENST00000484400 ENST00000495574 ENST00000464466
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DOCK1 (see all 15):
    hsa-miR-579 hsa-miR-31 hsa-miR-154 hsa-miR-520d-5p hsa-miR-539 hsa-miR-4263 hsa-miR-1271 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidDOCK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DOCK1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOCK1 (NM_001380)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOCK1
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOCK1
      QuantiTect SYBR Green Assays in human, mouse, rat DOCK1
      QuantiFast Probe-based Assays in human, mouse, rat DOCK1

    Additional mRNA sequence: 

    AK000789.1 AK091673.1 BC144632.1 BC146857.1 BX648342.1 D50857.1 

    11 DOTS entries:

    DT.315942  DT.101981392  DT.95235099  DT.40304609  DT.40226218  DT.91862097  DT.75157657  DT.100821267 
    DT.75106797  DT.75147184  DT.95197213 

    Selected AceView cDNA sequences (see all 164):

    CB136741 AA359407 T83590 CB242120 AI951513 BM725394 BQ029988 BX504728 
    BF062564 BQ009189 AW139803 BI255996 BU618781 BU556771 CD644252 BM558340 
    CK821163 AA599017 BG500272 AW573140 AW593879 BQ427869 AI758778 AV706726 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DOCK1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                -                 -                                                         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44a · 44b ^ 45a · 45b ^ 46 ^
    SP1:                          -                 -           -           -                                                           -                 -         
    SP2:                                                        -           -                                                           -                 -         
    SP3:                                            -           -                                                                                                   
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 47 ^ 48 ^ 49 ^ 50 ^ 51 ^ 52a · 52b ^ 53 ^ 54 ^ 55
    SP1:                                      -                     
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for DOCK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DOCK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACTCTTCT
    DOCK1 Expression
    About this image


    DOCK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)
             Hematopoietic Stem Cells Thymus
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Thyroid (Endocrine System)
    DOCK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOCK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159195

    UniProtKB/Swiss-Prot: DOCK1_HUMAN, Q14185
    Tissue specificity: Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate
    level in thymus, testes and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DOCK1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dock11 , 5 dedicator of cytokinesis 11, 5 87.56(n)1
    96.51(a)1
      7 (79.14 cM)5
    3306621  NM_001033420.21  NP_001028592.11 
     1346706875 
    chicken
    (Gallus gallus)
    Aves DOCK11 dedicator of cytokinesis 1 82.23(n)
    94.58(a)
      423960  XM_421819.4  XP_421819.4 
    lizard
    (Anolis carolinensis)
    Reptilia DOCK16
    dedicator of cytokinesis 1
    93(a)
    1 ↔ 1
    3(52899277-53436624)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.181892 Xenopus laevis transcribed sequence with weak similarity more 75.6(n)    CB592685.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dock11 dedicator of cytokinesis 1 75.36(n)
    84.57(a)
      572187  NM_001110011.1  NP_001103481.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mbc1 , 3 larval visceral muscle development3
    myoblast city1
    39(a)3
    51.87(n)1
    44.9(a)1
      428171  NM_001260338.21  NP_001247267.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ced-51 ced-5 44.93(n)
    32.32(a)
      177942  NM_069537.5  NP_501938.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Protein of unknown function with similarity to hum...
    17(a)
    1 → many
    XII(965897-971695) YLR422W


    ENSEMBL Gene Tree for DOCK1 (if available)
    TreeFam Gene Tree for DOCK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DOCK1 gene
    DOCK42  DOCK32  DOCK22  DOCK52  
    6 SIMAP similar genes for DOCK1 using alignment to 2 protein entries:     DOCK1_HUMAN (see all proteins):
    DKFZp779M164    DKFZp781J211    DOCK5    DOCK2    DOCK4    DOCK3

    DOCK1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DOCK1
    PGOHUM00000233544


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DOCK1 (see all 9876)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488445961,2
    --128766969(+) ATGCTC/GTTAGG 1 -- int10--------
    rs1453831491,2
    --128766987(+) ATAGAC/TGTATT 1 -- int10--------
    rs801494471,2
    C,F--128767150(+) TCAGTT/CGAGGA 1 -- int13Minor allele frequency- C:0.08WA NA EA 358
    rs1176687241,2
    F--128767271(+) GCAATG/ATGCTT 1 -- int11Minor allele frequency- A:0.03EA 120
    rs1910216621,2
    --128767308(+) GTAGCA/GGTAGA 1 -- int10--------
    rs1138927491,2
    F--128767319(+) CATCTC/TGATAG 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1157841981,2
    C,F--128767362(+) TCACCG/ATTACC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs122605411,2
    C,H--128767399(+) GCCAGA/GTCCAA 1 -- int17Minor allele frequency- G:0.02EA NS NA WA 540
    rs97337541,2
    C,F,A,H--128767442(+) CACACA/GCAATT 1 -- int115Minor allele frequency- G:0.47EA NS NA WA CSA 672
    rs1821467011,2
    --128767463(+) AGTATC/TCGGTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for DOCK1 (128593978 - 128843978 bp, first 250kb of DOCK1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DOCK1 (see all 46):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2392532CNV Deletion18987734
    esv2743151CNV Deletion23290073
    esv2672304CNV Deletion23128226
    esv2743173CNV Deletion23290073
    esv2743217CNV Deletion23290073
    esv2668745CNV Deletion23128226
    nsv821275CNV Deletion20802225
    esv2743140CNV Deletion23290073
    esv2743184CNV Deletion23290073
    esv2743228CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DOCK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOCK1
    DNA2.0 Custom Variant and Variant Library Synthesis for DOCK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601403    OMIM disorders: --

    13 diseases for DOCK1:    
    About MalaCards
    shigellosis    rabies    lateral sclerosis    amyotrophic lateral sclerosis
    asthma    hypertension    cervicitis    ovarian cancer
    alzheimer's disease    prostate cancer    breast cancer    prostatitis
    malaria


    DOCK1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DOCK1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 17671188 (1)

    Genetic Association Database (GAD): DOCK1
    Human Genome Epidemiology (HuGE) Navigator: DOCK1 (6 documents)

    Export disorders for DOCK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DOCK1 gene, integrated from 10 sources (see all 87):
    (articles sorted by number of sources associating them with DOCK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. (PubMed id 8657152)1, 2, 3, 9 Hasegawa H.... Matsuda M. (Mol. Cell. Biol. 1996)
    2. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. (PubMed id 9808620)1, 2, 9 Kiyokawa E....Matsuda M. (Genes Dev. 1998)
    3. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genes to diseases (G2D) computational method to identify asthma candidate genes. (PubMed id 18682798)1, 4 Tremblay K....Laprise C. (PLoS ONE 2008)
    7. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    8. Identification of an evolutionarily conserved superfamily of DOCK180- related proteins with guanine nucleotide exchange activity. (PubMed id 12432077)1, 2 Cote J.-F. and Vuori K. (J. Cell Sci. 2002)
    9. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. (PubMed id 12134158)1, 2 Brugnera E....Ravichandran K.S. (Nat. Cell Biol. 2002)
    10. Identification and kinetic analysis of the interaction between Nck-2 and DOCK180. (PubMed id 11240126)1, 2 Tu Y.... Wu C. (FEBS Lett. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1793 HGNC: 2987 AceView: DOCK1 Ensembl:ENSG00000150760 euGenes: HUgn1793
    ECgene: DOCK1 Kegg: 1793 H-InvDB: DOCK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DOCK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DOCK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DOCK1 gene:
    Search GeneIP for patents involving DOCK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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