Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DOC2B Gene

protein-coding   GIFtS: 50
GCID: GC17M000007

Double C2-Like Domains, Beta

(Previous names: double C2-like domains, beta-like)
(Previous symbol: DOC2BL)
  Search for DOC2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Double C2-Like Domains, Beta1 2
DOC2BL1 2 3
Double C2-Like Domains, Beta-Like1
doc2-beta2
Double C2-Like Domain-Containing Protein Beta2
Doc2-beta3

External Ids:    HGNC: 29861   Entrez Gene: 84472   Ensembl: ENSG000002726367   OMIM: 6045685   UniProtKB: Q141843   

Export aliases for DOC2B gene to outside databases

Previous GC identifers: GC17P000349 GC17M000091 GC17P9O0017 GC17P8G0009


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DOC2B Gene:
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which
contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused
with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to
be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. (provided by RefSeq,
Jul 2008)

GeneCards Summary for DOC2B Gene:
DOC2B (double C2-like domains, beta) is a protein-coding gene. GO annotations related to this gene include transporter activity and syntaxin binding. An important paralog of this gene is SYTL4.

UniProtKB/Swiss-Prot: DOC2B_HUMAN, Q14184
Function: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds
phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane
curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent
spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in
glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma
membrane in adipocytes (By similarity)

Gene Wiki entry for DOC2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_024972.9  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DOC2B gene promoter:
         Olf-1   AP-4   Tal-1beta   E47   POU2F1   Zic1   POU2F1a   POU2F1b   Chx10   POU2F1c   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DOC2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOC2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

DOC2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DOC2B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M000007:  view genomic region     (about GC identifiers)

Start:
5,810 bp from pter      End:
31,427 bp from pter
Size:
25,618 bases      Orientation:
minus strand

1 alternative location:
Chr17-,NW_003315952 6,009-31,420     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DOC2B_HUMAN, Q14184 (See protein sequence)
Recommended Name: Double C2-like domain-containing protein beta  
Size: 412 amino acids; 45949 Da
Subunit: Interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex
composed of SNAP25, STX1A and VAMP2; the interaction is calcium-dependent and competitive with SYT1. Interacts
with STX4; the interaction is calcium-dependent, increased by insulin and glucose, and mediates vesicle fusion
with plasma membrane in pancreatic cells and adipocytes. Interacts with STXBP3; the interaction is direct, occurs
at the cell membrane and regulates glucose-stimulated insulin secretion. May interact with UNC13A; the
interaction mediates targeting to the plasma membrane (By similarity). Interacts with cytoplasmic dynein light
chain DYNLT1

Explore the universe of human proteins at neXtProt for DOC2B: NX_Q14184

Explore proteomics data for DOC2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DOC2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003576.2  
    ENSEMBL proteins: 
     ENSP00000343665  

    DOC2B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DOC2B
    OriGene Protein Over-expression Lysate for DOC2B
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DOC2B
    GenScript Custom Purified and Recombinant Proteins Services for DOC2B
    Novus Biologicals DOC2B Protein
    Novus Biologicals DOC2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DOC2B 

    DOC2B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DOC2B
    Novus Biologicals DOC2B Antibodies
    Abcam antibodies for DOC2B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for DOC2B
    Search LSBio for Antibodies for DOC2B

    DOC2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DOC2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DOC2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DOC2B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR014638 Doc2
     IPR001565 Synaptotagmin
     IPR000008 C2_dom

    Graphical View of Domain Structure for InterPro Entry Q14184

    ProtoNet protein and cluster: Q14184

    2 Blocks protein domains:
    IPB000008 C2 domain
    IPB001565 Synaptotagmin signature


    UniProtKB/Swiss-Prot: DOC2B_HUMAN, Q14184
    Domain: C2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the
    calcium-dependent targeting to membranes (By similarity)
    Similarity: Contains 2 C2 domains


    Find genes that share domains with DOC2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOC2B_HUMAN, Q14184
    Function: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds
    phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane
    curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent
    spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in
    glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma
    membrane in adipocytes (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity IEA--
    GO:0005515protein binding ----
    GO:0005544calcium-dependent phospholipid binding ISS--
    GO:0019905syntaxin binding IEA--
         
    Find genes that share ontologies with DOC2B           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Doc2b):
     nervous system 

    Find genes that share phenotypes with DOC2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Doc2btm1Aljg for DOC2B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOC2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOC2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DOC2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DOC2B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DOC2B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DOC2B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DOC2B
    Predesigned siRNA for gene silencing in human, mouse, rat DOC2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DOC2B

    Clone
    Products:
         
    OriGene clones in human, mouse for DOC2B (see all 6)
    OriGene ORF clones in mouse, rat for DOC2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOC2B (NM_003585)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOC2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOC2B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DOC2B
    Browse ESI BIO Cell Lines and PureStem Progenitors for DOC2B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOC2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DOC2B_HUMAN, Q14184: Cytoplasm. Cytoplasmic granule (By similarity). Cell membrane; Peripheral membrane protein
    (By similarity). Note=Translocates to the plasma membrane in a calcium-dependent manner (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton4
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--
    GO:0005886plasma membrane ISS--
    GO:0008021synaptic vesicle IEA--
    GO:0015630microtubule cytoskeleton ----
    GO:0031201colocalizes with SNARE complex ISS--

    Find genes that share ontologies with DOC2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DOC2B
    Interactions:

        Search GeneGlobe Interaction Network for DOC2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DOC2B (Q141842 ENSP000003436654) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DYNLT1ENSP000003560564STRING: ENSP00000356056
    STXBP1ENSP000003623994STRING: ENSP00000362399
    UNC13BENSP000003677564STRING: ENSP00000367756
    BET1LENSP000003722104STRING: ENSP00000372210
    BNIP1ENSP000002316684STRING: ENSP00000231668
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008104protein localization ISS--
    GO:0031340positive regulation of vesicle fusion ISS--
    GO:0032024positive regulation of insulin secretion ISS--
    GO:0045956positive regulation of calcium ion-dependent exocytosis ISS--
    GO:0048791calcium ion-dependent exocytosis of neurotransmitter ISS--

    Find genes that share ontologies with DOC2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DOC2B

    1 HMDB Compound for DOC2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DOC2B gene: 
    NM_003585.4  

    Unigene Cluster for DOC2B:

    Double C2-like domains, beta
    Hs.551705  [show with all ESTs]
    Unigene Representative Sequence: D70830
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343572(uc010vpx.1) ENST00000609727
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DOC2B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DOC2B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DOC2B
    Predesigned siRNA for gene silencing in human, mouse, rat DOC2B
    Clone
    Products:
         
    OriGene clones in human, mouse for DOC2B (see all 6)
    OriGene ORF clones in mouse, rat for DOC2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DOC2B (NM_003585)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DOC2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOC2B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DOC2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOC2B
      QuantiTect SYBR Green Assays in human, mouse, rat DOC2B
      QuantiFast Probe-based Assays in human, mouse, rat DOC2B

    Additional mRNA sequence: D70830.1 

    2 DOTS entries:

    DT.40113573  DT.99979978 

    6 AceView cDNA sequences:

    BU739610 BM713588 BF434293 NM_003585 D70830 BF509185 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DOC2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCACTCAA
    DOC2B Expression
    About this image


    DOC2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
    DOC2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DOC2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.551705

    UniProtKB/Swiss-Prot: DOC2B_HUMAN, Q14184
    Tissue specificity: Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells
    (at protein level)

        Custom PCR Arrays for DOC2B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DOC2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOC2B
    QuantiTect SYBR Green Assays in human, mouse, rat DOC2B
    QuantiFast Probe-based Assays in human, mouse, rat DOC2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOC2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DOC2B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Doc2b1 , 5 double C2, beta1, 5 90.05(n)1
    95.15(a)1
      11 (45.92 cM)5
    134471  NM_007873.21  NP_031899.21 
     757689665 
    chicken
    (Gallus gallus)
    Aves DOC2B1 double C2-like domains, beta 83.5(n)
    88.89(a)
      417624  XM_415868.3  XP_415868.2 
    lizard
    (Anolis carolinensis)
    Reptilia DOC2B6
    double C2-like domains, beta

    1 ↔ 1
    AAWZ02038570(4748-9523)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia doc2b1 double C2-like domains, beta 73.01(n)
    85.53(a)
      100496262  XM_002934344.2  XP_002934390.1 
    zebrafish
    (Danio rerio)
    Actinopterygii doc2b1 double C2-like domains, beta 76.42(n)
    83.23(a)
      100006713  XM_001345351.5  XP_001345387.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta rabphilin-3A3 synaptic vesicle endocytosis protein
    transporter
    39(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea rbf-16
    Protein RBF-1, isoform c
    10(a)
    1 → many
    III(6675801-6703996) WBGene00004316


    ENSEMBL Gene Tree for DOC2B (if available)
    TreeFam Gene Tree for DOC2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DOC2B gene
    SYTL42  SYTL52  SYTL12  DOC2A2  SYTL32  RPH3A2  SYTL22  
    7 SIMAP similar genes for DOC2B using alignment to 1 protein entry:     DOC2B_HUMAN:
    RPH3A    DOC2A    SYT1    SYT14L    SYT5    SYT2
    SYT4

    Find genes that share paralogs with DOC2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DOC2B (see all 765)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456154301,2
    --56(+) CCCTGC/TTGAAT 1 -- int10--------
    rs1481704221,2
    C--78(+) TCTCTC/GGGGTC 1 -- int10--------
    rs1837799161,2
    --80(+) TCTGGA/GGTCTC 1 -- int10--------
    rs1885052171,2
    --174(+) CCACCA/GCCCAA 1 -- int10--------
    rs97475781,2
    C--293(-) TGTGTC/TAACCA 1 -- int10--------
    rs359981671,2
    C,F--302(+) ACAGT-/AGCCTG 1 -- int12Minor allele frequency- A:0.50NA CSA 4
    rs669881651,2
    C--303(+) CAGTG-/ACCTGC 1 -- int10--------
    rs1419906221,2
    --355(+) TGAGAA/GGCAGA 1 -- int10--------
    rs1917587861,2
    --366(+) AAATGA/GTATCT 1 -- int10--------
    rs1850836141,2
    C--565(+) CACACA/GCCCTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DOC2B (5810 - 31427 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DOC2B (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715204CNV Deletion23290073
    esv1591929CNV Deletion17803354
    esv2554624CNV Deletion19546169
    esv2715203CNV Deletion23290073
    esv2715205CNV Deletion23290073
    nsv907450CNV Loss21882294
    nsv907451CNV Loss21882294
    esv21587CNV Loss19812545
    nsv827848CNV Gain20364138
    nsv907452CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DOC2B
    DNA2.0 Custom Variant and Variant Library Synthesis for DOC2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604568    OMIM disorders: --


    Find genes that share disorders with DOC2B           About GenesLikeMe

    Genetic Association Database (GAD): DOC2B
    Human Genome Epidemiology (HuGE) Navigator: DOC2B (1 document)

    Export disorders for DOC2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DOC2B gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DOC2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of an isoform of Doc2 having two C2-like domains. (PubMed id 8554557)1, 2, 9 Sakaguchi G.... Takai Y. (Biochem. Biophys. Res. Commun. 1995)
    2. Genome-wide association study implicates PARD3B-based AIDS restriction. (PubMed id 21502085)1, 4 Troyer J.L....O'Brien S.J. (J. Infect. Dis. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. (PubMed id 9804756)1, 2 Nagano F.... Takai Y. (J. Biol. Chem. 1998)
    5. Doc2, a novel synaptic vesicle protein with two repeated C2-like domains. (PubMed id 7826360)1, 3 Orita S.... Takai Y. (Biochem. Biophys. Res. Commun. 1995)
    6. Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis. (PubMed id 21220648)2 Daoud H....Rouleau G.A. (Arch. Neurol. 2011)
    7. Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. (PubMed id 22036572)1 Yao J....Chapman E.R. (Cell 2011)
    8. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis. (PubMed id 17548353)2 Ke B.... Thurmond D.C. (J. Biol. Chem. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8447 HGNC: 2986 AceView: DOC2B Ensembl:ENSG00000272636 euGenes: HUgn8447
    ECgene: DOC2B H-InvDB: DOC2B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DOC2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DOC2B gene:
    Search GeneIP for patents involving DOC2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DOC2B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DOC2B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DOC2B  
     OriGene qSTAR qPCR primer pairs in human, mouse for DOC2B   OriGene Purified Protein for DOC2B  
     OriGene ORF clones in mouse, rat for DOC2B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DOC2B   OriGene Custom Protein Services for DOC2B  

     
     
     Block miRNA regulation of human, mouse, rat DOC2B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DOC2B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DOC2B Predesigned siRNA for gene silencing in human, mouse, rat DOC2B
     QuantiFast Probe-based Assays in human, mouse, rat DOC2B QuantiTect SYBR Green Assays in human, mouse, rat DOC2B
     Custom PCR Arrays for DOC2B Search Chromatin IP Primers for DOC2B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DOC2B  Search GeneGlobe Interaction Network for DOC2B
     Regulatory tfbs in DOC2B promoter
     GenScript Custom Purified and Recombinant Proteins Services for DOC2B GenScript cDNA clones with any tag delivered in your preferred vector for DOC2B
     GenScript Custom Assay Services for DOC2B GenScript Custom overexpressing Cell Line Services for DOC2B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DOC2B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DOC2B antibodies
     DOC2B proteins
     DOC2B lysates
     Antibodies for DOC2B
     See all of Abcam's Antibodies, Kits and Proteins for DOC2B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for DOC2B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DOC2B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DOC2B
     Browse SwitchGear Promoter luciferase reporter plasmids for DOC2B
     ThermoFisher Antibodies for DOC2B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DOC2B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DOC2B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DOC2B
     Search LSBio for Antibodies for DOC2B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DOC2B
      Search eBioscience for proteins for DOC2B
      Search eBioscience for elisas for DOC2B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DOC2B gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4