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Aliases for DOC2B Gene

Aliases for DOC2B Gene

  • Double C2-Like Domains, Beta 2 3
  • Doc2-Beta 3 4
  • DOC2BL 3 4
  • Double C2-Like Domain-Containing Protein Beta 3
  • Double C2-Like Domains, Beta-Like 2

External Ids for DOC2B Gene

Previous HGNC Symbols for DOC2B Gene

  • DOC2BL

Previous GeneCards Identifiers for DOC2B Gene

  • GC17P000349
  • GC17M000091
  • GC17P9O0017
  • GC17P8G0009
  • GC17M000007

Summaries for DOC2B Gene

Entrez Gene Summary for DOC2B Gene

  • There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for DOC2B Gene

DOC2B (Double C2-Like Domains, Beta) is a Protein Coding gene. GO annotations related to this gene include transporter activity and syntaxin binding. An important paralog of this gene is SYTL1.

UniProtKB/Swiss-Prot for DOC2B Gene

  • Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).

Gene Wiki entry for DOC2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOC2B Gene

Genomics for DOC2B Gene

Regulatory Elements for DOC2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOC2B Gene

Start:
142,789 bp from pter
End:
181,636 bp from pter
Size:
38,848 bases
Orientation:
Minus strand

Genomic View for DOC2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOC2B Gene

Proteins for DOC2B Gene

  • Protein details for DOC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14184-DOC2B_HUMAN
    Recommended name:
    Double C2-like domain-containing protein beta
    Protein Accession:
    Q14184
    Secondary Accessions:

    Protein attributes for DOC2B Gene

    Size:
    412 amino acids
    Molecular mass:
    45949 Da
    Quaternary structure:
    • Interacts with the SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex composed of SNAP25, STX1A and VAMP2; the interaction is calcium-dependent and competitive with SYT1. Interacts with STX4; the interaction is calcium-dependent, increased by insulin and glucose, and mediates vesicle fusion with plasma membrane in pancreatic cells and adipocytes. Interacts with STXBP3; the interaction is direct, occurs at the cell membrane and regulates glucose-stimulated insulin secretion. May interact with UNC13A; the interaction mediates targeting to the plasma membrane (By similarity). Interacts with cytoplasmic dynein light chain DYNLT1.

neXtProt entry for DOC2B Gene

Proteomics data for DOC2B Gene at MOPED

Post-translational modifications for DOC2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DOC2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DOC2B Gene

Domains for DOC2B Gene

Gene Families for DOC2B Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for DOC2B Gene

Suggested Antigen Peptide Sequences for DOC2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14184

UniProtKB/Swiss-Prot:

DOC2B_HUMAN :
  • Q14184
Domain:
  • C2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes (By similarity).
  • Contains 2 C2 domains.
genes like me logo Genes that share domains with DOC2B: view

Function for DOC2B Gene

Molecular function for DOC2B Gene

UniProtKB/Swiss-Prot Function: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).

Gene Ontology (GO) - Molecular Function for DOC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding --
GO:0005544 calcium-dependent phospholipid binding ISS --
GO:0019905 syntaxin binding IBA --
GO:0030276 clathrin binding IBA --
genes like me logo Genes that share ontologies with DOC2B: view

Phenotypes for DOC2B Gene

MGI mutant phenotypes for DOC2B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with DOC2B: view

Animal Models for DOC2B Gene

MGI Knock Outs for DOC2B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DOC2B Gene

Localization for DOC2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOC2B Gene

Cytoplasm. Cytoplasmic granule. Cell membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane in a calcium-dependent manner. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOC2B Gene COMPARTMENTS Subcellular localization image for DOC2B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 4
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DOC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane ISS --
GO:0031201 colocalizes_with SNARE complex ISS --
genes like me logo Genes that share ontologies with DOC2B: view

Pathways for DOC2B Gene

SuperPathways for DOC2B Gene

No Data Available

Interacting Proteins for DOC2B Gene

Selected Interacting proteins: Q14184-DOC2B_HUMAN for DOC2B Gene via MINT

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for DOC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0008104 protein localization ISS --
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IBA --
GO:0031340 positive regulation of vesicle fusion ISS --
genes like me logo Genes that share ontologies with DOC2B: view

No data available for Pathways by source for DOC2B Gene

Compounds for DOC2B Gene

(1) HMDB Compounds for DOC2B Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with DOC2B: view

Transcripts for DOC2B Gene

mRNA/cDNA for DOC2B Gene

(6) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DOC2B Gene

Double C2-like domains, beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOC2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DOC2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOC2B Gene

No ASD Table

Relevant External Links for DOC2B Gene

GeneLoc Exon Structure for
DOC2B
ECgene alternative splicing isoforms for
DOC2B

Expression for DOC2B Gene

mRNA expression in normal human tissues for DOC2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOC2B Gene

This gene is overexpressed in Brain - Cerebellum (5.0) and Brain - Cerebellar Hemisphere (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DOC2B Gene

SOURCE GeneReport for Unigene cluster for DOC2B Gene Hs.551705

mRNA Expression by UniProt/SwissProt for DOC2B Gene

Q14184-DOC2B_HUMAN
Tissue specificity: Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
genes like me logo Genes that share expressions with DOC2B: view

In Situ Assay Products

Orthologs for DOC2B Gene

This gene was present in the common ancestor of animals.

Orthologs for DOC2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DOC2B 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DOC2B 35
  • 93.27 (n)
  • 96.2 (a)
DOC2B 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOC2B 35
  • 89.16 (n)
  • 92.23 (a)
DOC2B 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Doc2b 35
  • 90.05 (n)
  • 95.15 (a)
Doc2b 16
Doc2b 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DOC2B 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOC2B 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Doc2b 35
  • 89.64 (n)
  • 95.39 (a)
chicken
(Gallus gallus)
Aves DOC2B 35
  • 83.5 (n)
  • 88.89 (a)
DOC2B 36
  • 25 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOC2B 36
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia doc2b 35
  • 73.01 (n)
  • 85.53 (a)
zebrafish
(Danio rerio)
Actinopterygii doc2b 35
  • 76.42 (n)
  • 83.23 (a)
DOC2B 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rph 36
  • 13 (a)
OneToMany
rabphilin-3A 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea rbf-1 36
  • 10 (a)
OneToMany
Species with no ortholog for DOC2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOC2B Gene

ENSEMBL:
Gene Tree for DOC2B (if available)
TreeFam:
Gene Tree for DOC2B (if available)

Paralogs for DOC2B Gene

Paralogs for DOC2B Gene

Selected SIMAP similar genes for DOC2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DOC2B: view

Variants for DOC2B Gene

Sequence variations from dbSNP and Humsavar for DOC2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1106175 -- 157,097(+) TTAGC(A/G)CTAAG intron-variant
rs1106176 -- 157,143(+) CGCTC(A/G)GCTTC intron-variant
rs1882989 -- 165,431(-) GATCA(C/T)GGTTC intron-variant
rs2223138 -- 155,173(-) CTCTA(C/T)AAAAA intron-variant
rs2294074 -- 172,420(-) GTCTG(C/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DOC2B Gene

Variant ID Type Subtype PubMed ID
nsv907450 CNV Loss 21882294
nsv907451 CNV Loss 21882294
nsv469538 CNV Complex 16826518
nsv907452 CNV Gain 21882294
esv27164 CNV Gain 19812545
esv2715203 CNV Deletion 23290073
esv2554624 CNV Deletion 19546169
esv1591929 CNV Deletion 17803354
esv2715204 CNV Deletion 23290073
esv2715205 CNV Deletion 23290073
nsv827848 CNV Gain 20364138
esv21587 CNV Loss 19812545

Relevant External Links for DOC2B Gene

HapMap Linkage Disequilibrium report
DOC2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOC2B Gene

Disorders for DOC2B Gene

Relevant External Links for DOC2B

Genetic Association Database (GAD)
DOC2B
Human Genome Epidemiology (HuGE) Navigator
DOC2B
genes like me logo Genes that share disorders with DOC2B: view

No data available for UniProtKB/Swiss-Prot for DOC2B Gene

Publications for DOC2B Gene

  1. Molecular cloning of an isoform of Doc2 having two C2-like domains. (PMID: 8554557) Sakaguchi G. … Takai Y. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  2. Doc2, a novel synaptic vesicle protein with two repeated C2-like domains. (PMID: 7826360) Orita S. … Takai Y. (Biochem. Biophys. Res. Commun. 1995) 2 3
  3. Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. (PMID: 9804756) Nagano F. … Takai Y. (J. Biol. Chem. 1998) 3 4
  4. Genome-wide association study implicates PARD3B-based AIDS restriction. (PMID: 21502085) Troyer J.L. … O'Brien S.J. (J. Infect. Dis. 2011) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for DOC2B Gene

Sources for DOC2B Gene

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