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Aliases for DOC2A Gene

Aliases for DOC2A Gene

  • Double C2-Like Domains, Alpha 2 3
  • Doc2-Alpha 3 4
  • Doc2 3 4
  • Double C2-Like Domain-Containing Protein Alpha 3

External Ids for DOC2A Gene

Previous GeneCards Identifiers for DOC2A Gene

  • GC16P029137
  • GC16M030339
  • GC16M030015
  • GC16M030054
  • GC16M029924
  • GC16M027677

Summaries for DOC2A Gene

Entrez Gene Summary for DOC2A Gene

  • There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for DOC2A Gene

DOC2A (Double C2-Like Domains, Alpha) is a Protein Coding gene. GO annotations related to this gene include transporter activity and calcium-dependent phospholipid binding. An important paralog of this gene is SYTL1.

UniProtKB/Swiss-Prot for DOC2A Gene

  • Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

Gene Wiki entry for DOC2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOC2A Gene

Genomics for DOC2A Gene

Regulatory Elements for DOC2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DOC2A Gene

Start:
30,005,509 bp from pter
End:
30,023,270 bp from pter
Size:
17,762 bases
Orientation:
Minus strand

Genomic View for DOC2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DOC2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOC2A Gene

Proteins for DOC2A Gene

  • Protein details for DOC2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14183-DOC2A_HUMAN
    Recommended name:
    Double C2-like domain-containing protein alpha
    Protein Accession:
    Q14183
    Secondary Accessions:
    • B4DEJ2
    • H3BNH6
    • Q6P4G4
    • Q7Z5G0
    • Q8IVX0

    Protein attributes for DOC2A Gene

    Size:
    400 amino acids
    Molecular mass:
    43959 Da
    Quaternary structure:
    • Interacts (via N-terminus) with UNC13A. Interacts with cytoplasmic dynein light chain DYNLT1. Interacts with UNC13D.

    Three dimensional structures from OCA and Proteopedia for DOC2A Gene

    Alternative splice isoforms for DOC2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOC2A Gene

Proteomics data for DOC2A Gene at MOPED

Post-translational modifications for DOC2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOC2A Gene

Domains for DOC2A Gene

Gene Families for DOC2A Gene

HGNC:
  • SYT :Synaptotagmins

Protein Domains for DOC2A Gene

Suggested Antigen Peptide Sequences for DOC2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14183

UniProtKB/Swiss-Prot:

DOC2A_HUMAN :
  • Q14183
Domain:
  • C2 domain 1 is involved in binding calcium and phospholipids.
  • Contains 2 C2 domains.
genes like me logo Genes that share domains with DOC2A: view

Function for DOC2A Gene

Molecular function for DOC2A Gene

UniProtKB/Swiss-Prot Function:
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

Gene Ontology (GO) - Molecular Function for DOC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005509 calcium ion binding IBA --
GO:0005515 protein binding IPI 18354201
GO:0005544 calcium-dependent phospholipid binding IBA --
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with DOC2A: view

Phenotypes for DOC2A Gene

genes like me logo Genes that share phenotypes with DOC2A: view

Animal Models for DOC2A Gene

MGI Knock Outs for DOC2A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DOC2A Gene

Localization for DOC2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOC2A Gene

Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DOC2A Gene COMPARTMENTS Subcellular localization image for DOC2A gene
Compartment Confidence
cytosol 3
lysosome 2
nucleus 2
vacuole 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DOC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle --
GO:0016020 membrane --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DOC2A: view

Pathways for DOC2A Gene

SuperPathways for DOC2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DOC2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006906 vesicle fusion IBA --
GO:0007268 synaptic transmission TAS 7826360
GO:0007399 nervous system development TAS 7826360
GO:0016079 synaptic vesicle exocytosis IBA --
GO:0017158 regulation of calcium ion-dependent exocytosis IMP 18354201
genes like me logo Genes that share ontologies with DOC2A: view

No data available for Pathways by source for DOC2A Gene

Compounds for DOC2A Gene

(1) HMDB Compounds for DOC2A Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(2) Novoseek inferred chemical compound relationships for DOC2A Gene

Compound -log(P) Hits PubMed IDs
phospholipid 56.5 4
calcium 29.2 4
genes like me logo Genes that share compounds with DOC2A: view

Transcripts for DOC2A Gene

Unigene Clusters for DOC2A Gene

Double C2-like domains, alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DOC2A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOC2A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for DOC2A Gene

GeneLoc Exon Structure for
DOC2A
ECgene alternative splicing isoforms for
DOC2A

Expression for DOC2A Gene

mRNA expression in normal human tissues for DOC2A Gene

mRNA differential expression in normal tissues according to GTEx for DOC2A Gene

This gene is overexpressed in Brain - Cortex (7.8), Brain - Frontal Cortex (BA9) (6.5), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Cerebellum (4.5), and Brain - Cerebellar Hemisphere (4.1).

Protein differential expression in normal tissues for DOC2A Gene

This gene is overexpressed in Frontal cortex (61.1) and Fetal Brain (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DOC2A Gene

SOURCE GeneReport for Unigene cluster for DOC2A Gene Hs.355281

mRNA Expression by UniProt/SwissProt for DOC2A Gene

Q14183-DOC2A_HUMAN
Tissue specificity: Predominantly expressed in brain. Also expressed in testis.
genes like me logo Genes that share expressions with DOC2A: view

Expression partners for DOC2A Gene

In Situ Assay Products

Orthologs for DOC2A Gene

This gene was present in the common ancestor of animals.

Orthologs for DOC2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DOC2A 35
  • 91.25 (n)
  • 96.25 (a)
DOC2A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DOC2A 35
  • 90 (n)
  • 95.5 (a)
DOC2A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Doc2a 35
  • 87.21 (n)
  • 94.44 (a)
Doc2a 16
Doc2a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DOC2A 35
  • 98.08 (n)
  • 97.17 (a)
DOC2A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Doc2a 35
  • 86.83 (n)
  • 93.25 (a)
oppossum
(Monodelphis domestica)
Mammalia DOC2A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOC2A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOC2A 36
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:dkey-93n13.3 35
  • 64.27 (n)
  • 66.58 (a)
DOC2A 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rabphilin-3A 37
  • 37 (a)
Rph 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rbf-1 36
  • 13 (a)
OneToMany
Species with no ortholog for DOC2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DOC2A Gene

ENSEMBL:
Gene Tree for DOC2A (if available)
TreeFam:
Gene Tree for DOC2A (if available)

Paralogs for DOC2A Gene

Paralogs for DOC2A Gene

genes like me logo Genes that share paralogs with DOC2A: view

Variants for DOC2A Gene

Sequence variations from dbSNP and Humsavar for DOC2A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1140239 - 30,010,081(-) GCGGG(A/G)GCGGC missense, reference, intron-variant
rs1140240 -- 30,009,545(-) AGGCA(A/C)GCTGG missense, reference, nc-transcript-variant, utr-variant-5-prime
rs3814880 -- 30,006,574(-) GGGAC(A/G)TGGAG intron-variant
rs3935873 -- 30,007,179(+) GGGAC(C/T)TGGCG synonymous-codon, reference, nc-transcript-variant
rs4566183 -- 30,010,012(-) GGGCC(A/C)CCACG reference, missense, nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DOC2A Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294

Relevant External Links for DOC2A Gene

HapMap Linkage Disequilibrium report
DOC2A
Human Gene Mutation Database (HGMD)
DOC2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOC2A Gene

Disorders for DOC2A Gene

Relevant External Links for DOC2A

Genetic Association Database (GAD)
DOC2A
Human Genome Epidemiology (HuGE) Navigator
DOC2A

No disorders were found for DOC2A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DOC2A Gene

Publications for DOC2A Gene

  1. Doc2, a novel synaptic vesicle protein with two repeated C2-like domains. (PMID: 7826360) Orita S. … Takai Y. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 23
  2. Molecular cloning of an isoform of Doc2 having two C2-like domains. (PMID: 8554557) Sakaguchi G. … Takai Y. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  3. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. (PMID: 18354201) Higashio H. … Sasaki T. (J. Immunol. 2008) 3 4 23
  4. Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. (PMID: 9736751) Mochida S. … Takai Y. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  5. Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. (PMID: 9804756) Nagano F. … Takai Y. (J. Biol. Chem. 1998) 3 4

Products for DOC2A Gene

Sources for DOC2A Gene

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