DNTTIP2 Gene
protein-coding GIFtS: 50
GCID: GC01M094331
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deoxynucleotidyltransferase, terminal, interacting protein...
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Aliases
for DNTTIP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Deoxynucleotidyltransferase, Terminal, Interacting Protein 21 2 | | FCF22 | | ERBP1 2 3 | | Acidic 82 KDa Protein MRNA2 | | TdIF21 2 3 | | Deoxynucleotidyltransferase Terminal-Interacting Protein 22 | | HSU155521 2 | | Estrogen Receptor Binding Protein2 | | TdT-Interacting Factor 22 3 | | TDIF23 | | LPTS-RP22 3 | | Estrogen Receptor-Binding Protein3 | | LPTS-Interacting Protein 22 3 | | Terminal Deoxynucleotidyltransferase-Interacting Factor 23 |
Export aliases for DNTTIP2 gene to outside databasesPrevious GC identifers: GC01M094048 GC01M092453 |
Summaries
for DNTTIP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DNTTIP2:
This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein bindsto and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminaldeoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructivepulmonary disease. (provided by RefSeq, Dec 2010)
UniProtKB/Swiss-Prot: TDIF2_HUMAN, Q5QJE6Function: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein
Gene Wiki entry for DNTTIP2
|
Genomic Views
for DNTTIP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DNTTIP2 gene promoter:
Elk-1 AML1a Nkx2-2 Ik-3 HEN1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DNTTIP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNTTIP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.1 Ensembl cytogenetic band: 1p22.1 HGNC cytogenetic band: 1p22.1DNTTIP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M094331: view genomic region
(about GC identifiers)
Start:
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94,333,373 bp from pter |
End:
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94,345,474 bp from pter |
Size:
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12,102 bases |
Orientation:
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minus strand |
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Proteins
for DNTTIP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TDIF2_HUMAN, Q5QJE6 (See
protein sequence)Recommended Name: Deoxynucleotidyltransferase terminal-interacting protein 2 Size: 756 amino acids; 84469 Da
Subunit: Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histonesfrom this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA
Subcellular location: Nucleus
Sequence caution: Sequence=AAA50601.1; Type=Frameshift; Positions=717, 726; Sequence=AAH47688.1; Type=Miscellaneousdiscrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAI21812.1; Type=Erroneous gene modelprediction;
Secondary accessions: Q12987 Q53H59 Q5TFJ4 Q6TLI0 Q76MJ8 Q86WX9Explore the universe of human proteins at neXtProt for DNTTIP2: NX_Q5QJE6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5QJE6
DNTTIP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055412.2
ENSEMBL proteins: ENSP00000411010 ENSP00000352137 ENSP00000434261
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
DNTTIP2 for ontologies About GeneDecksing
DNTTIP2 Antibody Products:
Assay Products for DNTTIP2: |
Protein
Domains /
Families
for DNTTIP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DNTTIP2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5QJE6ProtoNet protein and cluster: Q5QJE6 |
Function
for DNTTIP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TDIF2_HUMAN, Q5QJE6Function: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNTTIP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNTTIP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTTIP2 |
4 GenomeRNAi human phenotypes for DNTTIP2:
|
Pathways & Interactions
for DNTTIP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNTTIP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/31 Interacting proteins for DNTTIP2 (Q5QJE62, 3 ENSP000003521374) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
DNTTIP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DNTTIP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DNTTIP2
Search CenterWatch for drugs/clinical trials and news about DNTTIP2 / TDIF2
|
Transcripts
for DNTTIP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DNTTIP2 gene: NM_014597.4 Unigene Cluster for DNTTIP2: Deoxynucleotidyltransferase, terminal, interacting protein 2 Hs.85769 [show with all ESTs]Unigene Representative Sequence: AK1237027 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000436063(uc001dqf.3 uc010otm.2 uc009wdo.2) ENST00000462746
ENST00000496535 ENST00000359208 ENST00000460191 ENST00000496672 ENST00000528680
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNTTIP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNTTIP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DNTTIP2 (NM_014597) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DNTTIP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNTTIP2 |
Additional cDNA sequence: AB046574.1 AK123702.1 AK222722.1 AK292379.1 AK308808.1 AY336729.1 AY394925.1 BC001784.1 BC020634.1 BC047688.1 BC063040.1 BC130622.1 BX648593.1 U15552.1 12 DOTS entries: DT.100672258 DT.100814920 DT.101983694 DT.100029296 DT.75103290 DT.121436789 DT.95271196 DT.100814916 DT.91767617 DT.95271197 DT.95271199 DT.95271198 24/228 AceView cDNA sequences (see all 228): CB240557 AI916666 AU154061 AA832262 BU159818 BM977201 CB143817 BU783878 BI711261 BU689952 W38442 BQ549663 CA445986 BU153691 BC020634 BG575661 BM971186 AI078150 BM511644 AI926471 BU783778 BC001784 CB136180 BU947525
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DNTTIP2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DNTTIP2
|
Expression
for DNTTIP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DNTTIP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGAAAAAG
About this image
See DNTTIP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNTTIP2
SOURCE GeneReport for Unigene cluster: Hs.85769
UniProtKB/Swiss-Prot: TDIF2_HUMAN, Q5QJE6Tissue specificity: Widely expressed with higher levels in testis
SABiosciences Custom PCR Arrays for DNTTIP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNTTIP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DNTTIP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNTTIP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNTTIP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTTIP2 |
Orthologs
for DNTTIP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DNTTIP2 gene from 9/25 species (see all 25) About this table
ENSEMBL Gene Tree for DNTTIP2 (if available)
TreeFam Gene Tree for DNTTIP2 (if available) |
Paralogs
for DNTTIP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DNTTIP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DNTTIP2 (94333373 - 94345474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DNTTIP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNTTIP2 |
|
Disorders
/ Diseases
for DNTTIP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DNTTIP2 for disorders About GeneDecksing
OMIM gene information: 611199
OMIM disorders: --
3  diseases for DNTTIP2: About MalaCardschronic obstructive pulmonary disease pulmonary disease noma
Human Genome Epidemiology (HuGE) Navigator: DNTTIP2 (2 documents)
Export disorders for DNTTIP2 gene to outside databases
|
Publications
for DNTTIP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DNTTIP2 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with DNTTIP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. (PubMed id 15047147)1, 2, 3, 9 Bu H.... Zhu Y.-J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PubMed id 12786946)1, 2 Fujita K.... Koiwai O. (2003)
- A yeast two-hybrid screen reveals that osteopontin ass ociates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- TdIF2 is a nucleolar protein that promotes rRNA gene promoter activity. (PubMed id 21668587)1 Koiwai K....Koiwai O. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for DNTTIP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DNTTIP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DNTTIP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DNTTIP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DNTTIP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DNTTIP2 gene:
Search GeneIP for patents involving DNTTIP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DNTTIP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNTTIP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNTTIP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNTTIP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNTTIP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNTTIP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNTTIP2 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTTIP2 |
|  |  |  | | | | ThermoFisher Antibodies for DNTTIP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNTTIP2 |
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