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Aliases for DNTTIP2 Gene

Aliases for DNTTIP2 Gene

  • Deoxynucleotidyltransferase Terminal Interacting Protein 2 2 3
  • Deoxynucleotidyltransferase, Terminal, Interacting Protein 2 2 3 5
  • Acidic 82 KDa Protein MRNA 2 3
  • LPTS-Interacting Protein 2 3 4
  • TdT-Interacting Factor 2 3 4
  • LPTS-RP2 3 4
  • TdIF2 3 4
  • ERBP 3 4
  • Terminal Deoxynucleotidyltransferase-Interacting Factor 2 4
  • Estrogen Receptor Binding Protein 3
  • Estrogen Receptor-Binding Protein 4
  • HSU15552 3
  • FCF2 3

External Ids for DNTTIP2 Gene

Previous GeneCards Identifiers for DNTTIP2 Gene

  • GC01M094048
  • GC01M094331
  • GC01M092453

Summaries for DNTTIP2 Gene

Entrez Gene Summary for DNTTIP2 Gene

  • This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]

GeneCards Summary for DNTTIP2 Gene

DNTTIP2 (Deoxynucleotidyltransferase Terminal Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for DNTTIP2 Gene

  • Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.

Gene Wiki entry for DNTTIP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNTTIP2 Gene

Genomics for DNTTIP2 Gene

Regulatory Elements for DNTTIP2 Gene

Enhancers for DNTTIP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DNTTIP2 on UCSC Golden Path with GeneCards custom track

Promoters for DNTTIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNTTIP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNTTIP2 Gene

Chromosome:
1
Start:
93,866,283 bp from pter
End:
93,879,918 bp from pter
Size:
13,636 bases
Orientation:
Minus strand

Genomic View for DNTTIP2 Gene

Genes around DNTTIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNTTIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNTTIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNTTIP2 Gene

Proteins for DNTTIP2 Gene

  • Protein details for DNTTIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QJE6-TDIF2_HUMAN
    Recommended name:
    Deoxynucleotidyltransferase terminal-interacting protein 2
    Protein Accession:
    Q5QJE6
    Secondary Accessions:
    • Q12987
    • Q53H59
    • Q5TFJ4
    • Q6TLI0
    • Q76MJ8
    • Q86WX9

    Protein attributes for DNTTIP2 Gene

    Size:
    756 amino acids
    Molecular mass:
    84469 Da
    Quaternary structure:
    • Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA.
    SequenceCaution:
    • Sequence=AAA50601.1; Type=Frameshift; Positions=717, 726; Evidence={ECO:0000305}; Sequence=AAH47688.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAI21812.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DNTTIP2 Gene

Proteomics data for DNTTIP2 Gene at MOPED

Post-translational modifications for DNTTIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNTTIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNTTIP2 Gene

Domains & Families for DNTTIP2 Gene

Protein Domains for DNTTIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNTTIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNTTIP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DNTTIP2 Gene

Function for DNTTIP2 Gene

Molecular function for DNTTIP2 Gene

UniProtKB/Swiss-Prot Function:
Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.
genes like me logo Genes that share phenotypes with DNTTIP2: view

Animal Model Products

CRISPR Products

miRNA for DNTTIP2 Gene

miRTarBase miRNAs that target DNTTIP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNTTIP2 Gene

Localization for DNTTIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNTTIP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNTTIP2 Gene COMPARTMENTS Subcellular localization image for DNTTIP2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DNTTIP2 Gene

Pathways & Interactions for DNTTIP2 Gene

SuperPathways for DNTTIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNTTIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DNTTIP2: view

No data available for Pathways by source and SIGNOR curated interactions for DNTTIP2 Gene

Drugs & Compounds for DNTTIP2 Gene

No Compound Related Data Available

Transcripts for DNTTIP2 Gene

Unigene Clusters for DNTTIP2 Gene

Deoxynucleotidyltransferase, terminal, interacting protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNTTIP2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1:
SP2:
SP3: -
SP4:
SP5: - -

Relevant External Links for DNTTIP2 Gene

GeneLoc Exon Structure for
DNTTIP2
ECgene alternative splicing isoforms for
DNTTIP2

Expression for DNTTIP2 Gene

mRNA expression in normal human tissues for DNTTIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNTTIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), CD8 Tcells (9.7), Adrenal (8.9), Blymphocyte (7.5), and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNTTIP2 Gene



SOURCE GeneReport for Unigene cluster for DNTTIP2 Gene Hs.85769

mRNA Expression by UniProt/SwissProt for DNTTIP2 Gene

Q5QJE6-TDIF2_HUMAN
Tissue specificity: Widely expressed with higher levels in testis.
genes like me logo Genes that share expression patterns with DNTTIP2: view

Protein tissue co-expression partners for DNTTIP2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DNTTIP2 Gene

Orthologs for DNTTIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNTTIP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNTTIP2 35
  • 82.16 (n)
  • 72.28 (a)
DNTTIP2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNTTIP2 35
  • 84.26 (n)
  • 74.29 (a)
DNTTIP2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnttip2 35
  • 75.85 (n)
  • 64.76 (a)
Dnttip2 16
Dnttip2 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNTTIP2 35
  • 99.6 (n)
  • 99.74 (a)
DNTTIP2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910753 35
  • 75.14 (n)
  • 63.67 (a)
oppossum
(Monodelphis domestica)
Mammalia DNTTIP2 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNTTIP2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNTTIP2 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNTTIP2 36
  • 37 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8071 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
dnttip2 36
  • 25 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1142 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y49F6B.2 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FCF2 36
  • 32 (a)
OneToOne
FCF2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5032 36
  • 36 (a)
OneToOne
Species with no ortholog for DNTTIP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DNTTIP2 Gene

ENSEMBL:
Gene Tree for DNTTIP2 (if available)
TreeFam:
Gene Tree for DNTTIP2 (if available)

Paralogs for DNTTIP2 Gene

No data available for Paralogs for DNTTIP2 Gene

Variants for DNTTIP2 Gene

Sequence variations from dbSNP and Humsavar for DNTTIP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3747965 - 93,877,008(-) GATGA(G/T)GGGAA reference, missense
rs3179879 - 93,876,914(-) ATTCA(A/G)CCCCC reference, missense
rs35650636 - 93,876,646(-) GTCTG(C/T)GCCCA reference, missense
rs12748154 - 93,872,112(+) TCTTG(A/T)AAAAT reference, missense
rs41292661 - 93,876,505(+) TGTCT(C/T)CACTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DNTTIP2 Gene

Variant ID Type Subtype PubMed ID
esv998151 CNV Insertion 20482838

Variation tolerance for DNTTIP2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DNTTIP2 Gene

Disorders for DNTTIP2 Gene

Relevant External Links for DNTTIP2

Genetic Association Database (GAD)
DNTTIP2
Human Genome Epidemiology (HuGE) Navigator
DNTTIP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNTTIP2

No disorders were found for DNTTIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNTTIP2 Gene

Publications for DNTTIP2 Gene

  1. ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. (PMID: 15047147) Bu H. … Zhu Y.-J. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 23 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for DNTTIP2 Gene

Sources for DNTTIP2 Gene

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