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DNTTIP2 Gene

protein-coding   GIFtS: 53
GCID: GC01M094331

Deoxynucleotidyltransferase, Terminal, Interacting Protein...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxynucleotidyltransferase, Terminal, Interacting Protein 21 2     FCF22 5
ERBP2 3 5     HSU155522
Acidic 82 KDa Protein MRNA1 2     Deoxynucleotidyltransferase Terminal-Interacting Protein 22
TdT-Interacting Factor 22 3     Estrogen Receptor Binding Protein2
LPTS-RP22 3     TDIF23
TdIF22 3     Estrogen Receptor-Binding Protein3
LPTS-Interacting Protein 22 3     Terminal Deoxynucleotidyltransferase-Interacting Factor 23

External Ids:    HGNC: 240131   Entrez Gene: 308362   Ensembl: ENSG000000673347   OMIM: 6111995   UniProtKB: Q5QJE63   

Export aliases for DNTTIP2 gene to outside databases

Previous GC identifers: GC01M094048 GC01M092453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNTTIP2 Gene:
This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein
binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with
terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic
obstructive pulmonary disease. (provided by RefSeq, Dec 2010)

GeneCards Summary for DNTTIP2 Gene:
DNTTIP2 (deoxynucleotidyltransferase, terminal, interacting protein 2) is a protein-coding gene.

UniProtKB/Swiss-Prot: TDIF2_HUMAN, Q5QJE6
Function: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein

Gene Wiki entry for DNTTIP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNTTIP2 gene promoter:
         Elk-1   AML1a   Nkx2-2   Ik-3   HEN1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNTTIP2 promoter sequence
   Search Chromatin IP Primers for DNTTIP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNTTIP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1   Ensembl cytogenetic band:  1p22.1   HGNC cytogenetic band: 1p22.1

DNTTIP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNTTIP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M094331:  view genomic region     (about GC identifiers)

Start:
94,333,373 bp from pter      End:
94,345,474 bp from pter
Size:
12,102 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TDIF2_HUMAN, Q5QJE6 (See protein sequence)
Recommended Name: Deoxynucleotidyltransferase terminal-interacting protein 2  
Size: 756 amino acids; 84469 Da
Subunit: Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B
histones from this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA
Sequence caution: Sequence=AAA50601.1; Type=Frameshift; Positions=717, 726; Sequence=AAH47688.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=CAI21812.1;
Type=Erroneous gene model prediction;
Secondary accessions: Q12987 Q53H59 Q5TFJ4 Q6TLI0 Q76MJ8 Q86WX9

Explore the universe of human proteins at neXtProt for DNTTIP2: NX_Q5QJE6

Explore proteomics data for DNTTIP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DNTTIP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055412.2  
    ENSEMBL proteins: 
     ENSP00000411010   ENSP00000352137   ENSP00000434261  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR014810 Fcf2

    Graphical View of Domain Structure for InterPro Entry Q5QJE6

    ProtoNet protein and cluster: Q5QJE6


    Find genes that share domains with DNTTIP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDIF2_HUMAN, Q5QJE6
    Function: Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with DNTTIP2           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DNTTIP2:
     Decreased TP53 protein express  Increased S DNA content  Nuclear pre-40S maturation def  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNTTIP2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDIF2_HUMAN, Q5QJE6: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with DNTTIP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNTTIP2
    Interactions:

        Search GeneGlobe Interaction Network for DNTTIP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNTTIP2 (Q5QJE62, 3 ENSP000003521374) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with DNTTIP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNTTIP2 (TDIF2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNTTIP2 gene: 
    NM_014597.4  

    Unigene Cluster for DNTTIP2:

    Deoxynucleotidyltransferase, terminal, interacting protein 2
    Hs.85769  [show with all ESTs]
    Unigene Representative Sequence: AK123702
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436063(uc001dqf.3 uc010otm.2 uc009wdo.2) ENST00000462746
    ENST00000496535 ENST00000359208 ENST00000460191 ENST00000496672 ENST00000528680

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    Additional mRNA sequence: 

    AB046574.1 AK123702.1 AK222722.1 AK292379.1 AK308808.1 AY336729.1 AY394925.1 BC001784.1 
    BC020634.1 BC047688.1 BC063040.1 BC130622.1 BX648593.1 U15552.1 

    12 DOTS entries:

    DT.100672258  DT.100814920  DT.101983694  DT.100029296  DT.75103290  DT.121436789  DT.95271196  DT.100814916 
    DT.91767617  DT.95271197  DT.95271199  DT.95271198 

    Selected AceView cDNA sequences (see all 228):

    BU783778 BI711257 BM971186 AI090265 BM511644 AB046574 BE893634 AI632721 
    BG575661 BX280239 AA832262 AI916666 BU153691 BC001784 BM984035 AI078150 
    BE646107 AA772816 AU154061 BU159818 BQ216175 BU689952 AA559096 CB143817 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DNTTIP2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                    -                                                               
    SP4:                                                                                    
    SP5:                    -     -                                                         


    ECgene alternative splicing isoforms for DNTTIP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNTTIP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAAAAAG
    DNTTIP2 Expression
    About this image


    DNTTIP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
    DNTTIP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNTTIP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.85769

    UniProtKB/Swiss-Prot: TDIF2_HUMAN, Q5QJE6
    Tissue specificity: Widely expressed with higher levels in testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNTTIP2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnttip21 , 5 deoxynucleotidyltransferase, terminal, interacting more1, 5 75.85(n)1
    64.76(a)1
      3 (52.94 cM)5
    994801  NM_153806.11  NP_722501.11 
     1222744145 
    chicken
    (Gallus gallus)
    Aves DNTTIP26
    deoxynucleotidyltransferase, terminal, interacting...
    40(a)
    1 ↔ 1
    8(12718542-12727305)
    lizard
    (Anolis carolinensis)
    Reptilia DNTTIP26
    deoxynucleotidyltransferase, terminal, interacting...
    37(a)
    1 ↔ 1
    4(88625486-88635076)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80712 Xenopus laevis transcribed sequence with weak similarity more 75.84(n)    BQ732066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570550032   -- 75.73(n)   387309  57055003 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG11426
    --
    28(a)
    1 ↔ 1
    3R(3298180-3299499)
    worm
    (Caenorhabditis elegans)
    Secernentea Y49F6B.26
    Protein Y49F6B.2 (Y49F6B.2) mRNA, complete cds
    30(a)
    1 ↔ 1
    II(3502968-3504909) WBGene00021715
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FCF2(YLR051C)4 Essential nucleolar protein involved in the early steps more   --   12(246977-246324) 850740  NP_013152.1 


    ENSEMBL Gene Tree for DNTTIP2 (if available)
    TreeFam Gene Tree for DNTTIP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNTTIP2 (see all 355)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1821100401,2
    --94334565(+) TTCATA/GTTTGC 1 -- ds50010--------
    rs1851306581,2
    --94334593(+) AGTATA/GCTGGA 1 -- ds50010--------
    rs1143687721,2
    F--94334649(+) ACCAAG/ATATCA 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs66647191,2
    C,F,A,H--94334724(+) TGGAGA/CAGAGG 1 -- ds5001 ese3 trp318Minor allele frequency- C:0.36NS EA NA CSA 2222
    rs1410271681,2
    --94334738(+) GCTGGA/GTTAAC 1 -- ds50010--------
    rs1448360551,2
    --94334747(+) ACTTCA/GAAGAA 1 -- ds50010--------
    rs114459561,2
    C--94334766(+) AACTTA/-AAATT 1 -- ds50012Minor allele frequency- -:0.00NA CSA 4
    rs775375961,2
    C--94334766(+) CAACTA/TAAATT 1 -- ds50010--------
    rs120296371,2
    C,F,A--94334891(+) AGGTCA/GTATTC 1 -- ds500110Minor allele frequency- G:0.44NA CSA WA EA 508
    rs802122041,2
    C--94334910(+) TTTGTA/CTCCCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for DNTTIP2 (94333373 - 94345474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DNTTIP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv998151CNV Insertion20482838

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611199    OMIM disorders: --


    Find genes that share disorders with DNTTIP2           About GenesLikeMe

    Genetic Association Database (GAD): DNTTIP2
    Human Genome Epidemiology (HuGE) Navigator: DNTTIP2 (2 documents)

    Export disorders for DNTTIP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNTTIP2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with DNTTIP2)
        Utopia: connect your pdf to the dynamic
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    1. ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. (PubMed id 15047147)1, 2, 3, 9 Bu H.... Zhu Y.-J. (Biochem. Biophys. Res. Commun. 2004)
    2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PubMed id 12786946)1, 2 Fujita K.... Koiwai O. (Genes Cells 2003)
    5. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 30836 HGNC: 24013 AceView: ERBP Ensembl:ENSG00000067334 euGenes: HUgn30836
    ECgene: DNTTIP2 H-InvDB: DNTTIP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DNTTIP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNTTIP2 gene:
    Search GeneIP for patents involving DNTTIP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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