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Aliases for DNTTIP2 Gene

Aliases for DNTTIP2 Gene

  • Deoxynucleotidyltransferase Terminal Interacting Protein 2 2 3 5
  • Acidic 82 KDa Protein MRNA 2 3
  • LPTS-Interacting Protein 2 3 4
  • TdT-Interacting Factor 2 3 4
  • LPTS-RP2 3 4
  • TdIF2 3 4
  • ERBP 3 4
  • Deoxynucleotidyltransferase, Terminal, Interacting Protein 2 2
  • Deoxynucleotidyltransferase Terminal-Interacting Protein 2 3
  • Terminal Deoxynucleotidyltransferase-Interacting Factor 2 4
  • Estrogen Receptor Binding Protein 3
  • Estrogen Receptor-Binding Protein 4
  • HSU15552 3
  • FCF2 3

External Ids for DNTTIP2 Gene

Previous GeneCards Identifiers for DNTTIP2 Gene

  • GC01M094048
  • GC01M094331
  • GC01M092453

Summaries for DNTTIP2 Gene

Entrez Gene Summary for DNTTIP2 Gene

  • This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]

GeneCards Summary for DNTTIP2 Gene

DNTTIP2 (Deoxynucleotidyltransferase Terminal Interacting Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for DNTTIP2 Gene

  • Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.

Gene Wiki entry for DNTTIP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNTTIP2 Gene

Genomics for DNTTIP2 Gene

Regulatory Elements for DNTTIP2 Gene

Enhancers for DNTTIP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F093908 1.1 ENCODE 35.1 -29.4 -29382 2.1 PKNOX1 CREB3L1 ARID4B SIN3A SLC30A9 ZNF143 FOS KLF13 SP3 SP5 DNTTIP2 ENSG00000230439 CCDC18-AS1 DR1 GCLM
GH01F093078 1.2 ENCODE 22.5 +799.5 799483 4.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 CCDC18-AS1 SNORA66 SNORD21 RPL5 DNTTIP2 DR1 LOC100289500 ACTBP12 MTCO3P21 ENSG00000230439
GH01F093177 1.2 ENCODE 21.6 +699.9 699895 4.7 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF302 ZNF416 CCDC18-AS1 SNORA66 SNORD21 RPL5 DNTTIP2 LOC100289500 MTCO3P21 ACTBP12 ENSG00000233482 DR1
GH01F093661 1.6 FANTOM5 Ensembl ENCODE 13.5 +211.9 211915 13.8 PKNOX1 ATF1 SIN3A GATA2 FOS KLF13 NCOA1 REST PPARG MEF2D DNTTIP2 LOC100129046 BCAR3 GCLM CCDC18-AS1 TMED5 EVI5 FNBP1L GC01M093613 LOC102723480
GH01F094321 1.6 FANTOM5 Ensembl ENCODE 11.6 -445.4 -445427 7.3 ATF1 SIN3A FEZF1 GLIS2 FOS SP3 JUNB TSHZ1 TBX21 ZNF518A LOC107985092 DR1 CCDC18-AS1 DNTTIP2 ABCD3 ABCA4 ARHGAP29 F3 LOC105378859 GAPDHP29
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNTTIP2 on UCSC Golden Path with GeneCards custom track

Promoters for DNTTIP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078589 718 2000 ARNT CREB3L1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for DNTTIP2 Gene

93,866,283 bp from pter
93,879,918 bp from pter
13,636 bases
Minus strand

Genomic View for DNTTIP2 Gene

Genes around DNTTIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNTTIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNTTIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNTTIP2 Gene

Proteins for DNTTIP2 Gene

  • Protein details for DNTTIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deoxynucleotidyltransferase terminal-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q12987
    • Q53H59
    • Q5TFJ4
    • Q6TLI0
    • Q76MJ8
    • Q86WX9

    Protein attributes for DNTTIP2 Gene

    756 amino acids
    Molecular mass:
    84469 Da
    Quaternary structure:
    • Forms a ternary complex with DNTT and core histone; interaction with PCNA releases DNTT and H2A/H2B histones from this ternary complex. Interacts with ESR1, ESR2, PPARG and RXRA.
    • Sequence=AAA50601.1; Type=Frameshift; Positions=717, 726; Evidence={ECO:0000305}; Sequence=AAH47688.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=CAI21812.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DNTTIP2 Gene

Post-translational modifications for DNTTIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNTTIP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DNTTIP2 Gene

Domains & Families for DNTTIP2 Gene

Protein Domains for DNTTIP2 Gene


Suggested Antigen Peptide Sequences for DNTTIP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DNTTIP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DNTTIP2 Gene

Function for DNTTIP2 Gene

Molecular function for DNTTIP2 Gene

UniProtKB/Swiss-Prot Function:
Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein.

Gene Ontology (GO) - Molecular Function for DNTTIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DNTTIP2: view
genes like me logo Genes that share phenotypes with DNTTIP2: view

Animal Model Products

miRNA for DNTTIP2 Gene

miRTarBase miRNAs that target DNTTIP2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNTTIP2 Gene

Localization for DNTTIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNTTIP2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNTTIP2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DNTTIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with DNTTIP2: view

Pathways & Interactions for DNTTIP2 Gene

SuperPathways for DNTTIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNTTIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DNTTIP2: view

No data available for Pathways by source and SIGNOR curated interactions for DNTTIP2 Gene

Transcripts for DNTTIP2 Gene

Unigene Clusters for DNTTIP2 Gene

Deoxynucleotidyltransferase, terminal, interacting protein 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNTTIP2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP3: -
SP5: - -

Relevant External Links for DNTTIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNTTIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DNTTIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DNTTIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), CD8 Tcells (9.7), Adrenal (8.9), Blymphocyte (7.5), and Fetal ovary (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNTTIP2 Gene

Protein tissue co-expression partners for DNTTIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNTTIP2 Gene:


SOURCE GeneReport for Unigene cluster for DNTTIP2 Gene:


mRNA Expression by UniProt/SwissProt for DNTTIP2 Gene:

Tissue specificity: Widely expressed with higher levels in testis.
genes like me logo Genes that share expression patterns with DNTTIP2: view

Primer Products

No data available for mRNA differential expression in normal tissues for DNTTIP2 Gene

Orthologs for DNTTIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DNTTIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNTTIP2 34 35
  • 99.6 (n)
(Canis familiaris)
Mammalia DNTTIP2 34 35
  • 84.26 (n)
(Bos Taurus)
Mammalia DNTTIP2 34 35
  • 82.16 (n)
(Mus musculus)
Mammalia Dnttip2 34 16 35
  • 75.85 (n)
(Rattus norvegicus)
Mammalia LOC100910753 34
  • 75.14 (n)
(Ornithorhynchus anatinus)
Mammalia DNTTIP2 35
  • 67 (a)
(Monodelphis domestica)
Mammalia DNTTIP2 35
  • 46 (a)
(Gallus gallus)
Aves DNTTIP2 35
  • 40 (a)
(Anolis carolinensis)
Reptilia DNTTIP2 35
  • 37 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8071 34
(Danio rerio)
Actinopterygii dnttip2 35
  • 25 (a)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG1142 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea Y49F6B.2 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FCF2 35 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5032 35
  • 36 (a)
Species where no ortholog for DNTTIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DNTTIP2 Gene

Gene Tree for DNTTIP2 (if available)
Gene Tree for DNTTIP2 (if available)

Paralogs for DNTTIP2 Gene

No data available for Paralogs for DNTTIP2 Gene

Variants for DNTTIP2 Gene

Sequence variations from dbSNP and Humsavar for DNTTIP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1051394 -- 93,869,638(-) CTTTA(A/T)GGGAA utr-variant-3-prime
rs10557910 -- 93,868,982(+) AAAAC(-/TATTAT)TAAAA downstream-variant-500B
rs1063601 -- 93,875,753(-) GACCC(C/T)GGTCT reference, synonymous-codon
rs111325224 -- 93,876,138(+) ATGAA(A/T)GAGCC intron-variant
rs111492187 -- 93,878,340(+) AACAC(C/T)GGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNTTIP2 Gene

Variant ID Type Subtype PubMed ID
nsv998755 CNV loss 25217958
esv998151 CNV insertion 20482838
dgv143e59 CNV duplication 20981092

Variation tolerance for DNTTIP2 Gene

Residual Variation Intolerance Score: 66.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNTTIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNTTIP2 Gene

Disorders for DNTTIP2 Gene

Relevant External Links for DNTTIP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNTTIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNTTIP2 Gene

Publications for DNTTIP2 Gene

  1. ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor. (PMID: 15047147) Bu H. … Zhu Y.-J. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 22 64
  2. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PMID: 12786946) Fujita K. … Koiwai O. (Genes Cells 2003) 3 4 64
  5. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3 64

Products for DNTTIP2 Gene

Sources for DNTTIP2 Gene

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