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Aliases for DNTTIP1 Gene

Aliases for DNTTIP1 Gene

  • Deoxynucleotidyltransferase, Terminal, Interacting Protein 1 2 3 5
  • Terminal Deoxynucleotidyltransferase-Interacting Factor 1 3 4
  • TdT-Interacting Factor 1 3 4
  • TdT Binding Protein 2 3
  • C20orf167 3 4
  • Tdif1 3 4
  • Novel Protein Similar To Synaptotagmin 1 (SYT1 2
  • Chromosome 20 Open Reading Frame 167 2
  • P65) (Isoform 1) 2
  • DJ447F3.4 3

External Ids for DNTTIP1 Gene

Previous HGNC Symbols for DNTTIP1 Gene

  • C20orf167

Previous GeneCards Identifiers for DNTTIP1 Gene

  • GC20P045059
  • GC20P045106
  • GC20P045105
  • GC20P043853
  • GC20P044420
  • GC20P041162

Summaries for DNTTIP1 Gene

Entrez Gene Summary for DNTTIP1 Gene

  • DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNTTIP1 Gene

DNTTIP1 (Deoxynucleotidyltransferase, Terminal, Interacting Protein 1) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and nucleosome binding.

UniProtKB/Swiss-Prot for DNTTIP1 Gene

  • Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5-GNTGCATG-3 following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNTTIP1 Gene

Genomics for DNTTIP1 Gene

Regulatory Elements for DNTTIP1 Gene

Promoters for DNTTIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DNTTIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DNTTIP1 Gene

Chromosome:
20
Start:
45,791,937 bp from pter
End:
45,811,427 bp from pter
Size:
19,491 bases
Orientation:
Plus strand

Genomic View for DNTTIP1 Gene

Genes around DNTTIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNTTIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNTTIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNTTIP1 Gene

Proteins for DNTTIP1 Gene

  • Protein details for DNTTIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H147-TDIF1_HUMAN
    Recommended name:
    Deoxynucleotidyltransferase terminal-interacting protein 1
    Protein Accession:
    Q9H147
    Secondary Accessions:
    • B2RA18
    • Q96DE3
    • Q9BQP2
    • Q9H148

    Protein attributes for DNTTIP1 Gene

    Size:
    329 amino acids
    Molecular mass:
    37013 Da
    Quaternary structure:
    • Monomer and homodimer (PubMed:11473582, PubMed:25653165). A minor proportion may form homotrimers (PubMed:11473582). Interacts with ZNF541 (PubMed:21573134). Interacts with the terminal deoxynucleotidyltransferase DNTT (PubMed:11473582, PubMed:16371131). Interacts with TRERF1 (PubMed:16371131, PubMed:21573134). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain (PubMed:25653165). Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).

    Three dimensional structures from OCA and Proteopedia for DNTTIP1 Gene

neXtProt entry for DNTTIP1 Gene

Proteomics data for DNTTIP1 Gene at MOPED

Post-translational modifications for DNTTIP1 Gene

  • Ubiquitination at Lys 43, Lys 95, and Lys 134
  • Modification sites at PhosphoSitePlus

Other Protein References for DNTTIP1 Gene

Antibody Products

No data available for DME Specific Peptides for DNTTIP1 Gene

Domains & Families for DNTTIP1 Gene

Protein Domains for DNTTIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DNTTIP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H147

UniProtKB/Swiss-Prot:

TDIF1_HUMAN :
  • The N-terminal domain mediates dimerization.
Domain:
  • The N-terminal domain mediates dimerization.
  • The C-terminal domain mediates interaction with DNA and nucleosomes (PubMed:11473582, PubMed:25653165). It contains a HTH motif that mediates recognition of the consensus sequence (PubMed:23874396).
  • Contains 1 A.T hook DNA-binding domain.
genes like me logo Genes that share domains with DNTTIP1: view

No data available for Gene Families for DNTTIP1 Gene

Function for DNTTIP1 Gene

Molecular function for DNTTIP1 Gene

UniProtKB/Swiss-Prot Function:
Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5-GNTGCATG-3 following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.

Phenotypes for DNTTIP1 Gene

GenomeRNAi human phenotypes for DNTTIP1:
genes like me logo Genes that share phenotypes with DNTTIP1: view

Animal Model Products

CRISPR Products

miRNA for DNTTIP1 Gene

miRTarBase miRNAs that target DNTTIP1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNTTIP1 Gene

Localization for DNTTIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNTTIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNTTIP1 Gene COMPARTMENTS Subcellular localization image for DNTTIP1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DNTTIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 25653165
genes like me logo Genes that share ontologies with DNTTIP1: view

Pathways & Interactions for DNTTIP1 Gene

SuperPathways for DNTTIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNTTIP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DNTTIP1 Gene

Drugs & Compounds for DNTTIP1 Gene

No Compound Related Data Available

Transcripts for DNTTIP1 Gene

Unigene Clusters for DNTTIP1 Gene

Deoxynucleotidyltransferase, terminal, interacting protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNTTIP1 Gene

No ASD Table

Relevant External Links for DNTTIP1 Gene

GeneLoc Exon Structure for
DNTTIP1
ECgene alternative splicing isoforms for
DNTTIP1

Expression for DNTTIP1 Gene

mRNA expression in normal human tissues for DNTTIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNTTIP1 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for DNTTIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4), Lung (13.6), and Blymphocyte (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNTTIP1 Gene



SOURCE GeneReport for Unigene cluster for DNTTIP1 Gene Hs.472852

genes like me logo Genes that share expression patterns with DNTTIP1: view

Protein tissue co-expression partners for DNTTIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DNTTIP1 Gene

Orthologs for DNTTIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNTTIP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNTTIP1 35
  • 92.5 (n)
  • 97.57 (a)
DNTTIP1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNTTIP1 35
  • 92.96 (n)
  • 97.52 (a)
DNTTIP1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnttip1 35
  • 88.72 (n)
  • 96.65 (a)
Dnttip1 16
Dnttip1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNTTIP1 35
  • 99.77 (n)
  • 100 (a)
DNTTIP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnttip1 35
  • 88.72 (n)
  • 96.65 (a)
oppossum
(Monodelphis domestica)
Mammalia DNTTIP1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNTTIP1 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNTTIP1 35
  • 79.6 (n)
  • 82.21 (a)
DNTTIP1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNTTIP1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnttip1 35
  • 72.08 (n)
  • 77.5 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69166 35
zebrafish
(Danio rerio)
Actinopterygii LOC100331919 35
  • 66.43 (n)
  • 66.91 (a)
worm
(Caenorhabditis elegans)
Secernentea saeg-2 36
  • 24 (a)
OneToOne
Species with no ortholog for DNTTIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNTTIP1 Gene

ENSEMBL:
Gene Tree for DNTTIP1 (if available)
TreeFam:
Gene Tree for DNTTIP1 (if available)

Paralogs for DNTTIP1 Gene

(1) SIMAP similar genes for DNTTIP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNTTIP1: view

No data available for Paralogs for DNTTIP1 Gene

Variants for DNTTIP1 Gene

Sequence variations from dbSNP and Humsavar for DNTTIP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs408911 - 45,802,047(+) CAGCC(A/G)CCGGC reference, missense
rs1209754 -- 45,808,158(-) atgtt(A/G)gccag intron-variant
rs1211030 -- 45,808,285(-) ctcac(C/T)gcaac intron-variant
rs1211031 -- 45,808,258(-) caagc(G/T)attct intron-variant
rs1211423 -- 45,808,134(-) tcctg(A/G)cctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNTTIP1 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
esv270391 CNV Insertion 20981092
esv273747 CNV Insertion 20981092

Variation tolerance for DNTTIP1 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNTTIP1 Gene

HapMap Linkage Disequilibrium report
DNTTIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNTTIP1 Gene

Disorders for DNTTIP1 Gene

Relevant External Links for DNTTIP1

Genetic Association Database (GAD)
DNTTIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNTTIP1

No disorders were found for DNTTIP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNTTIP1 Gene

Publications for DNTTIP1 Gene

  1. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. (PMID: 11473582) Yamashita N. … Koiwai O. (Genes Cells 2001) 2 3 4 67
  2. TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm. (PMID: 19930467) Hayano T. … Koiwai O. (Genes Cells 2009) 3 23
  3. Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity. (PMID: 17663723) Kubota T. … Koiwai O. (Genes Cells 2007) 3 23
  4. Definition of the transcription factor TdIF1 consensus-binding sequence through genomewide mapping of its binding sites. (PMID: 25619743) Koiwai K. … Masai H. (Genes Cells 2015) 3
  5. Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting. (PMID: 25653165) Itoh T. … Schwabe J.W. (Nucleic Acids Res. 2015) 3

Products for DNTTIP1 Gene

Sources for DNTTIP1 Gene

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