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Aliases for DNTTIP1 Gene

Aliases for DNTTIP1 Gene

  • Deoxynucleotidyltransferase, Terminal, Interacting Protein 1 2 3
  • Terminal Deoxynucleotidyltransferase-Interacting Factor 1 3 4
  • TdT-Interacting Factor 1 3 4
  • TdT Binding Protein 2 3
  • C20orf167 3 4
  • Tdif1 3 4
  • Deoxynucleotidyltransferase Terminal-Interacting Protein 1 3
  • Novel Protein Similar To Synaptotagmin 1 (SYT1 2
  • Chromosome 20 Open Reading Frame 167 2
  • P65) (Isoform 1) 2
  • DJ447F3.4 3

External Ids for DNTTIP1 Gene

Previous Symbols for DNTTIP1 Gene

  • C20orf167

Summaries for DNTTIP1 Gene

Entrez Gene Summary for DNTTIP1 Gene

  • DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]

GeneCards Summary for DNTTIP1 Gene

DNTTIP1 (Deoxynucleotidyltransferase, Terminal, Interacting Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DNTTIP1 Gene

  • Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5-GNTGCATG-3 following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNTTIP1 Gene

Genomics for DNTTIP1 Gene

Genomic Location for DNTTIP1 Gene

Start:
45,791,937 bp from pter
End:
45,811,427 bp from pter
Size:
19,491 bases
Orientation:
Plus strand

Genomic View for DNTTIP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNTTIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNTTIP1 Gene

Regulatory Elements for DNTTIP1 Gene

Proteins for DNTTIP1 Gene

  • Protein details for DNTTIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H147-TDIF1_HUMAN
    Recommended name:
    Deoxynucleotidyltransferase terminal-interacting protein 1
    Protein Accession:
    Q9H147
    Secondary Accessions:
    • B2RA18
    • Q96DE3
    • Q9BQP2
    • Q9H148

    Protein attributes for DNTTIP1 Gene

    Size:
    329 amino acids
    Molecular mass:
    37013 Da
    Quaternary structure:
    • Monomer and homodimer (PubMed:11473582, PubMed:25653165). A minor proportion may form homotrimers (PubMed:11473582). Interacts with ZNF541 (By similarity). Interacts with the terminal deoxynucleotidyltransferase DNTT (PubMed:11473582, PubMed:16371131). Interacts with TRERF1 (PubMed:16371131). Identified in a histone deacetylase complex that contains DNTTIP1, HDAC1 and ELMSAN1; this complex assembles into a tetramer that contains four copies of each protein chain (PubMed:25653165).

    Three dimensional structures from OCA and Proteopedia for DNTTIP1 Gene

neXtProt entry for DNTTIP1 Gene

Proteomics data for DNTTIP1 Gene at MOPED

Post-translational modifications for DNTTIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys43, Lys95, and Lys134

Other Protein References for DNTTIP1 Gene

No data available for DME Specific Peptides for DNTTIP1 Gene

Domains for DNTTIP1 Gene

Protein Domains for DNTTIP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TDIF1_HUMAN
Domain:
  • The N-terminal domain mediates dimerization.:
    • Q9H147
  • The C-terminal domain mediates interaction with DNA and nucleosomes (PubMed:11473582, PubMed:25653165). It contains a HTH motif that mediates recognition of the consensus sequence (PubMed:23874396).:
    • Q9H147
  • Contains 1 A.T hook DNA-binding domain:
    • Q9H147
genes like me logo Genes that share domains with DNTTIP1: view

No data available for Gene Families for DNTTIP1 Gene

Function for DNTTIP1 Gene

Molecular function for DNTTIP1 Gene

UniProtKB/Swiss-Prot Function: Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro) (PubMed:11473582). Also acts as a transcriptional regulator, binding to the consensus sequence 5-GNTGCATG-3 following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA.

Gene Ontology (GO) - Molecular Function for DNTTIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 11473582
GO:0005515 protein binding IPI 11473582
GO:0031491 nucleosome binding IDA 25653165
GO:0042803 protein homodimerization activity IDA 11473582
genes like me logo Genes that share ontologies with DNTTIP1: view

Phenotypes for DNTTIP1 Gene

GenomeRNAi human phenotypes for DNTTIP1:
genes like me logo Genes that share phenotypes with DNTTIP1: view

miRNA for DNTTIP1 Gene

miRTarBase miRNAs that target DNTTIP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DNTTIP1 Gene

Localization for DNTTIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNTTIP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNTTIP1 Gene COMPARTMENTS Subcellular localization image for DNTTIP1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DNTTIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex IDA 25653165
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with DNTTIP1: view

Pathways for DNTTIP1 Gene

SuperPathways for DNTTIP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNTTIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DNTTIP1: view

No data available for Pathways by source for DNTTIP1 Gene

Transcripts for DNTTIP1 Gene

mRNA/cDNA for DNTTIP1 Gene

Unigene Clusters for DNTTIP1 Gene

Deoxynucleotidyltransferase, terminal, interacting protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DNTTIP1 Gene

No ASD Table

Relevant External Links for DNTTIP1 Gene

GeneLoc Exon Structure for
DNTTIP1
ECgene alternative splicing isoforms for
DNTTIP1

Expression for DNTTIP1 Gene

mRNA expression in normal human tissues for DNTTIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNTTIP1 Gene

This gene is overexpressed in Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNTTIP1 Gene

SOURCE GeneReport for Unigene cluster for DNTTIP1 Gene Hs.472852

genes like me logo Genes that share expressions with DNTTIP1: view

Orthologs for DNTTIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DNTTIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNTTIP1 36
  • 99.77 (n)
  • 100 (a)
DNTTIP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNTTIP1 36
  • 92.5 (n)
  • 97.57 (a)
DNTTIP1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNTTIP1 36
  • 92.96 (n)
  • 97.52 (a)
DNTTIP1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnttip1 36
  • 88.72 (n)
  • 96.65 (a)
Dnttip1 16
Dnttip1 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNTTIP1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNTTIP1 37
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnttip1 36
  • 88.72 (n)
  • 96.65 (a)
chicken
(Gallus gallus)
Aves DNTTIP1 36
  • 79.6 (n)
  • 82.21 (a)
DNTTIP1 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNTTIP1 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69166 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dnttip1 36
  • 72.08 (n)
  • 77.5 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331919 36
  • 66.43 (n)
  • 66.91 (a)
worm
(Caenorhabditis elegans)
Secernentea saeg-2 37
  • 24 (a)
OneToOne
Species with no ortholog for DNTTIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DNTTIP1 Gene

ENSEMBL:
Gene Tree for DNTTIP1 (if available)
TreeFam:
Gene Tree for DNTTIP1 (if available)

Paralogs for DNTTIP1 Gene

Selected SIMAP similar genes for DNTTIP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DNTTIP1: view

No data available for Paralogs for DNTTIP1 Gene

Variants for DNTTIP1 Gene

Sequence variations from dbSNP and Humsavar for DNTTIP1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs388420 -- 45,804,349(-) ATGAA(C/G)AGAAG intron-variant
rs390386 -- 45,810,335(+) ATACA(G/T)GCCAA intron-variant
rs399672 -- 45,809,660(+) TACTT(A/G)AAGAG intron-variant
rs404433 -- 45,796,355(+) catca(A/T)tagag intron-variant
rs407326 -- 45,795,070(+) tggga(C/T)cacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNTTIP1 Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897
esv270391 CNV Insertion 20981092
esv273747 CNV Insertion 20981092

Relevant External Links for DNTTIP1 Gene

HapMap Linkage Disequilibrium report
DNTTIP1

Disorders for DNTTIP1 Gene

Relevant External Links for DNTTIP1

Genetic Association Database (GAD)
DNTTIP1
genes like me logo Genes that share disorders with DNTTIP1: view

No data available for UniProtKB/Swiss-Prot for DNTTIP1 Gene

Publications for DNTTIP1 Gene

  1. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. (PMID: 11473582) Yamashita N. … Koiwai O. (Genes Cells 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. TdIF1 recognizes a specific DNA sequence through its Helix-Turn-Helix and AT-hook motifs to regulate gene transcription. (PMID: 23874396) Kubota T. … Koiwai K. (PLoS ONE 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for DNTTIP1 Gene

Sources for DNTTIP1 Gene

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