Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

DNTT Gene

protein-coding GIFtS: 65
GCID: GC10P098072

DNA Nucleotidylexotransferase

(Previous names: deoxynucleotidyltransferase, terminal)

See DNTT-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
DNA Nucleotidylexotransferase¹ ²		Terminal Transferase² ³
Terminal Deoxynucleotidyltransferase¹ ² ³		EC 2.7.7.31³ ⁸
TDT² ³ ⁵		Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase²
Deoxynucleotidyltransferase, Terminal¹ ²		Terminal Deoxyribonucleotidyltransferase²
Terminal Addition Enzyme² ³		EC 2.7.7⁸

External Ids:	HGNC: 2983¹	Entrez Gene: 1791²	Ensembl: ENSG00000107447⁷	OMIM: 187410⁵	UniProtKB: P04053³

Export aliases for DNTT gene to outside databases

Previous GC identifers: GC10P096957 GC10P097297 GC10P098195 GC10P097728 GC10P098054 GC10P091692

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DNTT Gene:

This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that

catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the

encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes

during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line

elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments.

Alternatively spliced transcript variants encoding different isoforms of this gene have been described. (provided

by RefSeq, Jul 2008)

GeneCards Summary for DNTT Gene:

DNTT (DNA nucleotidylexotransferase) is a protein-coding gene. Diseases associated with DNTT include myelodysplastic syndromes, and acute leukemia. GO annotations related to this gene include DNA nucleotidylexotransferase activity and DNA-directed DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot: TDT_HUMAN, P04053

Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside

5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of

nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the

maturation of B- and T-cells

Gene Wiki entry for DNTT (Terminal deoxynucleotidyl transferase) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000010.10 NC_018921.2 NT_030059.14

Regulatory elements:

Regulatory transcription factor binding sites in the DNTT gene promoter:
AML1a AP-1 RREB-1 ATF-2 NF-AT c-Ets-1 AREB6 CP2 c-Jun NF-AT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNTT promoter sequence

Search Chromatin IP Primers for DNTT

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNTT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24 Ensembl cytogenetic band: 10q24.1 HGNC cytogenetic band: 10q23-q24

DNTT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNTT gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P098072: view genomic region (about GC identifiers)

Start:	98,064,085 bp from pter	End:	98,098,321 bp from pter
Size:	34,237 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TDT_HUMAN, P04053 (See protein sequence)

Recommended Name: DNA nucleotidylexotransferase

Size: 509 amino acids; 58536 Da

Cofactor: Magnesium

Subunit: Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from

this complex by PCNA

1 PDB 3D structure from and Proteopedia for DNTT:

2COE (3D)

Secondary accessions: Q53FH1 Q5W103 Q96E50

Alternative splicing: 2 isoforms: P04053-1 P04053-2

Explore the universe of human proteins at neXtProt for DNTT: NX_P04053

Explore proteomics data for DNTT at MOPED

Post-translational modifications:

Ubiquitination² at Lys59, Lys199, Lys209, Lys222, Lys250, Lys261, Lys290, Lys339, Lys371, Lys386,
Lys393, Lys408, Lys425, Lys468

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for DNTT (P04053) (see all 9)

GHDVDFL

SQYACQR

DHFQKCF

DTEGIPCL

See DNTT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001017520.1 NP_004079.3

ENSEMBL proteins:

ENSP00000360216 ENSP00000401169

DNTT Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for DNTT OriGene Custom MassSpec OriGene Custom Protein Services for DNTT
	GenScript Custom Purified and Recombinant Proteins Services for DNTT
	Novus Biologicals DNTT Protein Novus Biologicals DNTT Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DNTT
	Search eBioscience for Proteins for DNTT
	antibodies-online proteins for DNTT (3 products)
	antibodies-online peptides for DNTT

DNTT Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for DNTT OriGene Custom Antibody Services for DNTT
	Novus Biologicals DNTT Antibodies
	Abcam antibodies for DNTT
	Cloud-Clone Corp. Antibodies for DNTT
	ThermoFisher Antibody for DNTT
	antibodies-online antibodies for DNTT (110 products)

DNTT Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for DNTT
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DNTT
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DNTT Cloud-Clone Corp. CLIAs for DNTT
	Search eBioscience for ELISAs for DNTT
	antibodies-online kits for DNTT (14 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

POL: DNA polymerases

Selected InterPro protein domains (see all 10):

IPR001726 TdT/Mu

IPR002934 Nucleotidyltransferase

IPR027292 TdT

IPR010996 DNA_pol_b-like_N

IPR018944 DNA_pol_lambd_fingers_domain

Graphical View of Domain Structure for InterPro Entry P04053

ProtoNet protein and cluster: P04053

5 Blocks protein domains:

IPB001357 BRCT domain

IPB001726 DNA nucleotidylexotransferase (TDT) signature

IPB002008 DNA-polymerase family X pol beta-like signature

IPB002054 DNA polymerase family X

IPB002934 DNA polymerase

UniProtKB/Swiss-Prot: TDT_HUMAN, P04053

Similarity: Belongs to the DNA polymerase type-X family

Similarity: Contains 1 BRCT domain

Find genes that share domains with DNTT About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: TDT_HUMAN, P04053

Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside

5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of

nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the

maturation of B- and T-cells

Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

Genatlas biochemistry entry for DNTT:

deoxynucleotidyltransferase,terminal

Enzyme Numbers (IUBMB): EC 2.7.7.31¹ ² EC 2.7.7²

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003824	catalytic activity	--	--
GO:0003887	DNA-directed DNA polymerase activity	IEA	--
GO:0003912	DNA nucleotidylexotransferase activity	IEA	--
GO:0016779	nucleotidyltransferase activity	--	--

Find genes that share ontologies with DNTT About GenesLikeMe

Phenotypes:
3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Dntt):

hematopoietic system

immune system

normal

Find genes that share phenotypes with DNTT About GenesLikeMe

Animal Models:
MGI mouse knock-outs for DNTT: Dntt^tm1Fwa Dntt^tm1Gfn

genOway: Develop your customized and physiologically relevant rodent model for DNTT

miRNA Products:		Block miRNA regulation of human, mouse, rat DNTT using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate DNTT
		SwitchGear 3'UTR luciferase reporter plasmid: DNTT 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DNTT
		Predesigned siRNA for gene silencing in human, mouse, rat DNTT

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DNTT

Clone Products:		OriGene clones in human, mouse for DNTT (see all 13) OriGene ORF clones in mouse, rat for DNTT OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DNTT (NM_004088)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNTT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNTT

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNTT
		Browse ESI BIO Cell Lines and PureStem Progenitors for DNTT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-12428) for DNTT

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

TDT_HUMAN, P04053: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	3
extracellular	3
mitochondrion	3
cytoskeleton	2
endoplasmic reticulum	2
plasma membrane	2
vacuole	2

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--

Find genes that share ontologies with DNTT About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for DNTT About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Non-homologous end-joining

Non-homologous end-joining

0.37

Validated targets of C-MYC transcriptional repression

Validated targets of C-MYC transcriptional repression

Hematopoietic cell lineage

Hematopoietic cell lineage

Find genes that share SuperPaths with DNTT About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for DNTT

Validated targets of C-MYC transcriptional repression

2 Kegg Pathways (Kegg details for DNTT):

	Non-homologous end-joining
	Hematopoietic cell lineage

Pathway & Disease-focused RT² Profiler PCR Array including DNTT:

Lymphoma in human mouse rat

Interactions:

GeneGlobe Interaction Network for DNTT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DNTT (P04053³ ENSP00000360216⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DNTTIP2	Q5QJE6³, ENSP00000352137⁴	I2D: score=2 STRING: ENSP00000352137
PCNA	P12004³, ENSP00000368438⁴	I2D: score=2 STRING: ENSP00000368438
XRCC6	P12956³, ENSP00000352257⁴	I2D: score=2 STRING: ENSP00000352257
CUL3	Q13618³, ENSP00000264414⁴	I2D: score=1 STRING: ENSP00000264414
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006259	DNA metabolic process	--	--
GO:0006304	DNA modification	IEA	--

Find genes that share ontologies with DNTT About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for DNTT

Browse compounds at ApexBio

Browse Tocris compounds for DNTT (TDT)

3 HMDB Compounds for DNTT About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

1 DrugBank Compound for DNTT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2',3'-Dideoxyadenosine-5'-Triphosphate	--	--	target	--	17139284 17016423 10592235

Selected Novoseek inferred chemical compound relationships for DNTT gene (see all 55) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cd 79	75.2	4	17498589 (1), 18686384 (1), 19665353 (1), 12446447 (1)
naphthol as-d chloroacetate	71	1	14692536 (1)
paraffin	46.4	15	9343323 (5), 9227346 (2), 10233410 (1), 16454553 (1) (see all 9)
sanguinarine	44.2	2	11770015 (1)
dutp	43.8	10	10193519 (1), 15911970 (1), 18309685 (1), 19059832 (1) (see all 8)
parathion	42.6	4	2162699 (3), 16212545 (1)
fitc	41.5	9	9845437 (2), 7924695 (1), 16113043 (1), 7895530 (1) (see all 6)
eb 1089	40.6	3	8903423 (1), 9846632 (1)
bzatp	40.6	1	12899380 (1)
propidium	38.1	1	9060958 (1)

Find genes that share compounds with DNTT About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for DNTT gene (2 alternative transcripts):

NM_001017520.1 NM_004088.3

Unigene Cluster for DNTT:

Deoxynucleotidyltransferase, terminal

Hs.534206 [show with all ESTs]

Unigene Representative Sequence: NM_004088

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371174 ENST00000419175(uc001kmf.3 uc001kmg.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat DNTT using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate DNTT
		SwitchGear 3'UTR luciferase reporter plasmid: DNTT 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DNTT
		Predesigned siRNA for gene silencing in human, mouse, rat DNTT

Clone Products:		OriGene clones in human, mouse for DNTT (see all 13) OriGene ORF clones in mouse, rat for DNTT OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DNTT (NM_004088)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNTT
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNTT

Primer Products:		OriGene qPCR primer pairs and template standards for DNTT OriGene qSTAR qPCR primer pairs in human, mouse for DNTT
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DNTT
		QuantiTect SYBR Green Assays in human, mouse, rat DNTT
		QuantiFast Probe-based Assays in human, mouse, rat DNTT

Flow Cytometry
Products:

eBioscience FlowRNA Probe Sets ( VA1-12428) for DNTT

Additional mRNA sequence:

AB046378.1 AK130771.1 AK223317.1 AK313615.1 BC012920.1 K01919.1 M26147.1

5 DOTS entries:

DT.75163025 DT.114143 DT.100739794 DT.121216459 DT.100686314

21 AceView cDNA sequences:

BX281386 BP368640 AK130771 CR597750 NM_004088 BG392804 AL559015 BM454641

K01919 BX340469 BX348525 BC012920 BP367455 BP367885 AB046378 AL558696

BG258914 AW951054 AA306371 M11722 AL580462

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DNTT About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b
SP1:
SP2:
SP3:											-

ECgene alternative splicing isoforms for DNTT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

DNTT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTTATGACTG

About this image

DNTT expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 9) fully expand


Blood (Cardiovascular System) fully expand to see all 9 entries
Pro B-Cells Hematopoietic Bone Marrow

Thymus (Hematopoietic System) fully expand to see all 4 entries
Double Negative 3 Thymocytes Thymus

Brain (Nervous System) fully expand to see all 3 entries
Lateral Ventricle

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Bone (Muscoskeletal System)
Bone Marrow

DNTT Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

DNTT Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.534206

Pathway & Disease-focused RT² Profiler PCR Array including DNTT:

Lymphoma in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for DNTT OriGene qSTAR qPCR primer pairs in human, mouse for DNTT
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DNTT
		QuantiTect SYBR Green Assays in human, mouse, rat DNTT
		QuantiFast Probe-based Assays in human, mouse, rat DNTT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for DNTT gene from Selected species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dntt^{1 , 5}	deoxynucleotidyltransferase, terminal^{1, 5}	80.55(n)¹ 80.75(a)¹		19 (34.32 cM)⁵ 21673¹ NM_001043228.1¹ NP_001036693.1¹ 41029275⁵
chicken (Gallus gallus)	Aves	DNTT¹	deoxynucleotidyltransferase, terminal	68.6(n) 64.4(a)		396351 NM_205389.1 NP_990720.1
lizard (Anolis carolinensis)	Reptilia	DNTT⁶	DNA nucleotidylexotransferase	62(a)	1 ↔ 1	GL343262.1(1035028-1194831)
African clawed frog (Xenopus laevis)	Amphibia	dntt-A²	deoxynucleotidyltransferase, terminal	74.14(n)		U07803.1
zebrafish (Danio rerio)	Actinopterygii	dntt¹	deoxynucleotidyltransferase, terminal	54.5(n) 48.25(a)		544653 NM_001014817.1 NP_001014817.1

ENSEMBL Gene Tree for DNTT (if available)
TreeFam Gene Tree for DNTT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for DNTT gene

POLB² POLM² POLL²

1 SIMAP similar gene for DNTT using alignment to 2 protein entries: TDT_HUMAN (see all proteins):

POLM

Find genes that share paralogs with DNTT About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115445960^1,2	F	--	98062096(+)	`GGGCAG/ACCTGA`	2	--	us2k¹		1		WA	118
rs145683589^1,2		--	98062127(+)	`ACATCC/TCAGTA`	2	--	us2k¹		0	--	--	--	--
rs141161617^1,2		--	98062155(+)	`TTACT-/GCTTAG`	2	--	us2k¹		0	--	--	--	--
rs78831834^1,2		--	98062201(+)	`GGAACA/GAACAC`	2	--	us2k¹		0	--	--	--	--
rs74153622^1,2	C,F	--	98062255(+)	`CTGCAG/ACACCA`	2	--	us2k¹		2		WA	120
rs142620372^1,2	C	--	98062436(+)	`CCCTTC/TTGTTA`	2	--	us2k¹		0	--	--	--	--
rs74153623^1,2	C,F	--	98062486(+)	`TTTCAT/GGACTT`	2	--	us2k¹		2		WA	120
rs117893245^1,2	F	--	98062535(+)	`TTAGAC/TAGCTG`	2	--	us2k¹		1		EA	120
rs144646268^1,2		--	98062753(+)	`GGCCAG/TCCATG`	2	--	us2k¹		0	--	--	--	--
rs151247216^1,2		--	98062847(+)	`CAACAC/TGGTGA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DNTT (98064085 - 98098321 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for DNTT: About this table

Variant ID	Type	Subtype	PubMed ID
nsv831949	CNV	Gain	17160897
nsv831950	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing DNTT

DNA2.0 Custom Variant and Variant Library Synthesis for DNTT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 187410 OMIM disorders: --

10 diseases for DNTT:
About MalaCards

myelodysplastic syndromes acute leukemia spiradenoma acute biphenotypic leukemia

adenosine deaminase deficiency dendritic cell tumor acute myeloid leukemia primary malignant lymphoma

lymphoblastic lymphoma gastrointestinal system disease

8 inferred disease relationships from the University of Copenhagen DISEASES database for DNTT:

Vascular disease Leukemia Lymphoma Brain disease

Carcinoma Eye disease Heart disease Gastrointestinal system disease

Find genes that share disorders with DNTT About GenesLikeMe

Selected Novoseek inferred disease relationships for DNTT gene (see all 52) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma lymphoblastic	86.2	23	11190795 (2), 18480005 (2), 7937725 (2), 9042293 (2) (see all 16)
lymphoblastic leukemia acute	77.1	22	9343323 (3), 7723388 (2), 16454553 (2), 16918360 (1) (see all 14)
acute leukemia	76.2	25	7723388 (3), 1338518 (2), 18426728 (2), 7524307 (1) (see all 17)
t-all	76.1	19	14961034 (3), 17430665 (2), 1698878 (2), 8152264 (1) (see all 11)
leukemia	74.8	48	8371592 (2), 8709648 (2), 8366299 (2), 8555067 (2) (see all 39)
leukaemia lymphocytic	64.9	13	17430665 (2), 8217792 (1), 8709648 (1), 9697877 (1) (see all 9)
sarcoma granulocytic	63.8	2	7572794 (2)
blast crisis	62.2	4	7924695 (1), 1996546 (1), 1592097 (1)
b-all	61.8	3	17430665 (1), 8683996 (1), 17652839 (1)
minimal residual disease	61.7	6	7723388 (1), 8555067 (1), 9576196 (1), 1836104 (1) (see all 5)

Genetic Association Database (GAD): DNTT
Human Genome Epidemiology (HuGE) Navigator: DNTT (1 document)

Export disorders for DNTT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for DNTT gene, integrated from 10 sources (see all 372):
(articles sorted by number of sources associating them with DNTT)

Utopia: connect your pdf to the dynamic
world of online information

Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. (PubMed id 8163485)^{1, 2, 9} Yang B.... Coleman M.S. (J. Biol. Chem. 1994)
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)^{1, 4} Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PubMed id 12786946)^{1, 2} Fujita K.... Koiwai O. (Genes Cells 2003)
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389)^{1, 2} Mahajan K.N. and Mitchell B.S. (Proc. Natl. Acad. Sci. U.S.A. 2003)
Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. (PubMed id 11473582)^{1, 2} Yamashita N.... Koiwai O. (Genes Cells 2001)
Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen. (PubMed id 11554927)^{1, 2} Ibe S....Koiwai O. (Genes Cells 2001)
Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene. (PubMed id 3395350)^{1, 2} Koiwai O. and Morita A. (Biochem. Biophys. Res. Commun. 1988)
Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region. (PubMed id 2833741)^{1, 2} Riley L.K.... Coleman M.S. (Proc. Natl. Acad. Sci. U.S.A. 1988)
Expression of human terminal deoxynucleotidyl transferase in Escherichia coli. (PubMed id 2863268)^{1, 2} Peterson R.C....Bollum F.J. (J. Biol. Chem. 1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 1791	HGNC: 2983	AceView: DNTT	Ensembl:ENSG00000107447	euGenes: HUgn1791
ECgene: DNTT	Kegg: 1791	H-InvDB: DNTT

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for DNTT	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DNTT	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DNTT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for DNTT gene:
Search GeneIP for patents involving DNTT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for DNTT		OriGene RNAi products in human, mouse, rat for DNTT
	OriGene qPCR primer pairs and template standards for DNTT		OriGene Protein Over-expression Lysate for DNTT
	OriGene Custom Mass Spec		OriGene clones in human, mouse for DNTT
	OriGene qSTAR qPCR primer pairs in human, mouse for DNTT		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for DNTT		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DNTT		OriGene Custom Protein Services for DNTT

	Block miRNA regulation of human, mouse, rat DNTT using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing DNTT
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNTT		Predesigned siRNA for gene silencing in human, mouse, rat DNTT
	QuantiFast Probe-based Assays in human, mouse, rat DNTT		QuantiTect SYBR Green Assays in human, mouse, rat DNTT
	PCR Arrays including human, mouse, rat DNTT		Search Chromatin IP Primers for DNTT
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat DNTT		GeneGlobe Interaction Network for DNTT
	Regulatory tfbs in DNTT promoter

	GenScript Custom Purified and Recombinant Proteins Services for DNTT		GenScript cDNA clones with any tag delivered in your preferred vector for DNTT
	GenScript Custom Assay Services for DNTT		GenScript Custom overexpressing Cell Line Services for DNTT
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for DNTT (TDT)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

	Drugs for DNTT
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DNTT antibodies
	DNTT proteins
	DNTT lysates

	Antibodies for DNTT
	See all of Abcam's Antibodies, Kits and Proteins for DNTT
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for DNTT
	Antibodies for DNTT
	ELISAs for DNTT
	CLIAs for DNTT

Browse ESI BIO Cell Lines and PureStem Progenitors for DNTT

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT

	SwitchGear 3'UTR luciferase reporter plasmids for DNTT
	SwitchGear Promoter luciferase reporter plasmids for DNTT

ThermoFisher Antibody for DNTT

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNTT

Browse compounds at ApexBio

Search Addgene for plasmids for DNTT

	Search eBioscience for proteins for DNTT
	Search eBioscience for elisas for DNTT
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for DNTT

	antibodies-online antibodies for DNTT (110 products)
	antibodies-online kits for DNTT (14 products)
	antibodies-online peptides for DNTT
	antibodies-online proteins for DNTT (3 products)

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DNTT gene at Home site.

Version: 3.12.304 29 Jan 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

DNTT Gene

DNA Nucleotidylexotransferase

Aliases
for DNTT gene

Summaries
for DNTT gene

Genomic Views
for DNTT gene

Proteins
for DNTT gene

DNTT Human Recombinant Protein Products:

DNTT Antibody Products:

DNTT Assay Products:

Domains /
Families
for DNTT gene

Function
for DNTT gene

Localization
for DNTT gene

Pathways & Interactions
for DNTT gene

Drugs & Compounds
for DNTT gene

Transcripts
for DNTT gene

Expression
for DNTT gene

Orthologs
for DNTT gene

Paralogs
for DNTT gene

Genomic Variants
for DNTT gene

Disorders / Diseases
for DNTT gene

Publications
for DNTT gene

External Searches for DNTT gene

Genome Databases showing DNTT gene

Other Databases showing DNTT gene

Specialized Databases showing DNTT gene

Intellectual Property
for DNTT gene

Products
for DNTT gene

View Random Gene

Leukemia Nonlymphocytic Acute
Myeloid Leukemia
Lymphoblastic Leukemia Acute Childhood
Medulloblastoma
Leukemia Lymphocytic Chronic
Glioma
Herpes Simplex
Erythroleukemia
Lymphoma T-Cell
Thymoma
dysplasia
Dermatitis Atopic
Carcinoma
B-ALL
Gliosis
ACUTE LEUKEMIA
Minimal Residual Disease
Karyotype Abnormal
Myeloid Leukemia Chronic
Leukemia
epithelial tumor
Alzheimers Disease
Blast Crisis
Hematopoietic Malignancies
Lymphoma High-Grade
Cancer
Lymphoma Lymphoblastic
Hematologic Malignancies
Cancer Lung
somatic mutations
Lymphoma
GASTRIC CARCINOMA
T-ALL
Burkitt Lymphoma
Ewings sarcoma
SKIN LESION
immunodeficiency
Leukemia Promyelocytic Acute
Atrophy
MYELOMA
Rheumatoid Arthritis
Chromosomal Aberrations
Tumors
Sarcoma Granulocytic
Lupus Nephritis
Metastasis
residual disease
Lymphoma Non-Hodgkins
Lymphoblastic Leukemia Acute
Leukemia Myelomonocytic Acute
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC

GeneCards Plus

Advanced Search

Export list of displayed genes

DNTT Gene

DNA Nucleotidylexotransferase

Aliasesfor DNTT gene

Summariesfor DNTT gene

Genomic Viewsfor DNTT gene

Proteinsfor DNTT gene

DNTT Human Recombinant Protein Products:

DNTT Antibody Products:

DNTT Assay Products:

Domains /Familiesfor DNTT gene

Functionfor DNTT gene

Localizationfor DNTT gene

Pathways & Interactionsfor DNTT gene

Drugs & Compoundsfor DNTT gene

Transcriptsfor DNTT gene

Expression for DNTT gene

Orthologsfor DNTT gene

Paralogsfor DNTT gene

Genomic Variantsfor DNTT gene

Disorders / Diseasesfor DNTT gene

Publicationsfor DNTT gene

External Searches for DNTT gene

Genome Databases showing DNTT gene

Other Databases showing DNTT gene

Specialized Databases showing DNTT gene

Intellectual Propertyfor DNTT gene

Productsfor DNTT gene

View Random Gene

Aliases
for DNTT gene

Summaries
for DNTT gene

Genomic Views
for DNTT gene

Proteins
for DNTT gene

Domains /
Families
for DNTT gene

Function
for DNTT gene

Localization
for DNTT gene

Pathways & Interactions
for DNTT gene

Drugs & Compounds
for DNTT gene

Transcripts
for DNTT gene

Expression
for DNTT gene

Orthologs
for DNTT gene

Paralogs
for DNTT gene

Genomic Variants
for DNTT gene

Disorders / Diseases
for DNTT gene

Publications
for DNTT gene

Intellectual Property
for DNTT gene

Products
for DNTT gene