Aliases for DNTT Gene
Aliases for DNTT Gene
External Ids for DNTT Gene
- HGNC: 2983
- Entrez Gene: 1791
- Ensembl: ENSG00000107447
- OMIM: 187410
- UniProtKB: P04053
Previous GeneCards Identifiers for DNTT Gene
- GC10P096957
- GC10P097297
- GC10P098195
- GC10P097728
- GC10P098054
- GC10P091692
- GC10P098072
Summaries for DNTT Gene
-
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for DNTT Gene
DNTT (DNA Nucleotidylexotransferase) is a Protein Coding gene. Diseases associated with DNTT include Myeloid Sarcoma and Lymphoblastic Lymphoma. Among its related pathways are DNA Double-Strand Break Repair and Hematopoietic cell lineage. Gene Ontology (GO) annotations related to this gene include DNA-directed DNA polymerase activity and DNA polymerase activity. An important paralog of this gene is POLM.
UniProtKB/Swiss-Prot for DNTT Gene
-
Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5-triphosphate to the 3-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNTT Gene
Genomics for DNTT Gene
GeneHancer (GH) Regulatory Elements for DNTT Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10I096304 | Promoter/Enhancer | 0.7 | EPDnew dbSUPER | 550.8 | +0.1 | 89 | 0.1 | DNTT ENSG00000229418 GC10M096095 | ||
GH10I096305 | Enhancer | 0.4 | FANTOM5 dbSUPER | 554.5 | +0.9 | 884 | 0.1 | DNTT ENSG00000229418 BLNK CCNJ ZNF518A CC2D2B GC10M096095 | ||
GH10I096302 | Enhancer | 0.4 | dbSUPER | 550.8 | -1.7 | -1709 | 0.9 | PKNOX1 USF1 | DNTT BLNK ENSG00000229418 GC10M096095 | |
GH10I096303 | Enhancer | 0.2 | dbSUPER | 550.8 | -0.8 | -822 | 0.4 | DNTT ENSG00000229418 BLNK GC10M096095 | ||
GH10I096297 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 0.8 | -4.6 | -4639 | 3.8 | MAFK NR2F2 | BLNK DNTT ENSG00000229418 GC10M096095 |
Regulatory Element Products
Genomic Locations for DNTT Gene
- chr10:96,304,328-96,338,564
- (GRCh38/hg38)
- Size:
- 34,237 bases
- Orientation:
- Plus strand
- chr10:98,064,085-98,098,321
- (GRCh37/hg19)
Genomic View for DNTT Gene
- Cytogenetic band:
-
- 10q24.1 by Ensembl
- 10q24.1 by Entrez Gene
- 10q24.1 by HGNC


RefSeq DNA sequence for DNTT Gene
Proteins for DNTT Gene
-
Protein details for DNTT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04053-TDT_HUMAN
- Recommended name:
- DNA nucleotidylexotransferase
- Protein Accession:
- P04053
- Q53FH1
- Q5W103
- Q96E50
Protein attributes for DNTT Gene
- Size:
- 509 amino acids
- Molecular mass:
- 58536 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA. Interacts with TRERF1 (PubMed:16371131).
Protein Expression for DNTT Gene
Selected DME Specific Peptides for DNTT Gene
- P04053:
-
- WKAIRVDLV
- GHDVDFL
- DTEGIPCL
- SQYACQR
- SEEEIFAHLGL
- DHFQKCF
- KTSEKWFRMG
- ALLGWTGSRQF
- ELARRKGFRVENE
Post-translational modifications for DNTT Gene
- Ubiquitination at Lys59, posLast=199199, Lys209, Lys222, Lys250, posLast=261261, Lys290, posLast=339339, Lys371, posLast=386386, posLast=393393, posLast=408408, Lys425, and Lys468
Other Protein References for DNTT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Assay Products
Domains & Families for DNTT Gene
Gene Families for DNTT Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for DNTT Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for DNTT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04053- Family:
-
- Belongs to the DNA polymerase type-X family.
Function for DNTT Gene
Molecular function for DNTT Gene
- GENATLAS Biochemistry:
- deoxynucleotidyltransferase,terminal
- UniProtKB/Swiss-Prot CatalyticActivity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- UniProtKB/Swiss-Prot Function:
- Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5-triphosphate to the 3-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Enzyme Numbers (IUBMB) for DNTT Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003887 | DNA-directed DNA polymerase activity | IEA | -- |
GO:0003912 | DNA nucleotidylexotransferase activity | TAS,IDA | 11473582 |
GO:0005515 | protein binding | IPI | 11473582 |
GO:0016740 | transferase activity | IEA | -- |
Phenotypes for DNTT Gene
- MGI mutant phenotypes for DNTT:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for DNTT:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Model Products
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-
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DNTT Gene
Localization for DNTT Gene
Subcellular locations from UniProtKB/Swiss-Prot for DNTT Gene
- Nucleus.
- Cytosol (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | IEA | -- |
GO:0000791 | euchromatin | IEA | -- |
GO:0005634 | nucleus | IDA | 16371131 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for DNTT Gene
Pathways by source for DNTT Gene
1 BioSystems pathway for DNTT Gene
2 KEGG pathways for DNTT Gene
Interacting Proteins for DNTT Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006259 | DNA metabolic process | IDA | 11473582 |
GO:0006304 | DNA modification | IEA | -- |
GO:0033198 | response to ATP | IEA | -- |
GO:0071897 | DNA biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for DNTT Gene
Drugs & Compounds for DNTT Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
Transcripts for DNTT Gene
mRNA/cDNA for DNTT Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (21) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DNTT Gene
CRISPR Products
-
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available DNTT gene related products
- orf clones - Search results for available DNTT gene related products
- Applied Biological Materials Clones for DNTT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||
SP3: | - |
Expression for DNTT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Pro B-Cells Hematopoietic Bone Marrow
mRNA differential expression in normal tissues according to GTEx for DNTT Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNTT Gene
NURSA nuclear receptor signaling pathways regulating expression of DNTT Gene:
DNTTSOURCE GeneReport for Unigene cluster for DNTT Gene:
Hs.534206Evidence on tissue expression from TISSUES for DNTT Gene
- Blood(3.4)
- Bone marrow(2.9)
- Nervous system(2.7)
- Muscle(2.6)
- Heart(2.5)
- Eye(2.3)
- Liver(2.3)
- Lung(2.3)
- Intestine(2.2)
- Kidney(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for DNTT
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OriGene qPCR primer pairs for DNTT
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No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNTT Gene
Orthologs for DNTT Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | DNTT 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | DNTT 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | DNTT 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Dntt 33 |
|
||
mouse (Mus musculus) |
Mammalia | Dntt 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | DNTT 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | DNTT 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | DNTT 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | DNTT 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | dntt 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | dntt-A 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | dntt 33 34 |
|
||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11749 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for DNTT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DNTT Gene
Variants for DNTT Gene
SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000005301 | -- | 96,304,598(+) | A/G | coding_sequence_variant, missense_variant | |
rs1000073333 | -- | 96,319,003(+) | G/A | intron_variant | |
rs1000114593 | -- | 96,310,366(+) | A/C | intron_variant | |
rs1000225770 | -- | 96,328,519(+) | C/T | intron_variant | |
rs1000260902 | -- | 96,322,523(+) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2761620 | CNV | gain | 21179565 |
nsv1110852 | OTHER | inversion | 24896259 |
nsv831949 | CNV | gain | 17160897 |
nsv831950 | CNV | gain | 17160897 |
Additional Variant Information for DNTT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DNTT
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNTT Gene
Disorders for DNTT Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
myeloid sarcoma |
|
|
lymphoblastic lymphoma |
|
|
acute leukemia |
|
|
ewing sarcoma |
|
|
burkitt lymphoma |
|
Additional Disease Information for DNTT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DNTT Gene
Publications for DNTT Gene
- Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. (PMID: 8163485) Yang B … Coleman MS (The Journal of biological chemistry 1994) 3 4 22 58
- Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase. (PMID: 18429817) Maezawa S … Koiwai O (Genes to cells : devoted to molecular & cellular mechanisms 2008) 3 22 58
- Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity. (PMID: 17663723) Kubota T … Koiwai O (Genes to cells : devoted to molecular & cellular mechanisms 2007) 3 22 58
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
- Direct binding of TReP-132 with TdT results in reduction of TdT activity. (PMID: 16371131) Fujisaki S … Koiwai O (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4 58
Products for DNTT Gene
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- Invitrogen Antibodies for DNTT
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 148 available DNTT Antibodies ranked by validation data
- Compare Top DNTT Antibodies
- Recommended
- 28 WB Antibodies (anti-mouse)
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- 1 IHC Antibody (anti-human)
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- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Search results for 15 available DNTT Elisa Kits ranked by validation data
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Sources for DNTT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
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