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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNTT Gene

protein-coding   GIFtS: 65
GCID: GC10P098054

DNA Nucleotidylexotransferase

(Previous names: deoxynucleotidyltransferase, terminal)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DNA Nucleotidylexotransferase1 2     Terminal Transferase2 3
Terminal Deoxynucleotidyltransferase1 2 3     EC 2.7.7.313 8
TDT2 3 5     Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase2
Deoxynucleotidyltransferase, Terminal1 2     Terminal Deoxyribonucleotidyltransferase2
Terminal Addition Enzyme2 3     EC 2.7.78

External Ids:    HGNC: 29831   Entrez Gene: 17912   Ensembl: ENSG000001074477   OMIM: 1874105   UniProtKB: P040533   

Export aliases for DNTT gene to outside databases

Previous GC identifers: GC10P096957 GC10P097297 GC10P098195 GC10P097728 GC10P091692


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNTT Gene:
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that
catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the
encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes
during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line
elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments.
Alternatively spliced transcript variants encoding different isoforms of this gene have been described. (provided
by RefSeq, Jul 2008)

GeneCards Summary for DNTT Gene: 
DNTT (DNA nucleotidylexotransferase) is a protein-coding gene. Diseases associated with DNTT include acute non lymphoblastic leukemia, and spiradenoma, and among its related super-pathways are Non-homologous end joining. GO annotations related to this gene include DNA nucleotidylexotransferase activity and DNA-directed DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot: TDT_HUMAN, P04053
Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside
5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of
nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the
maturation of B- and T-cells

Gene Wiki entry for DNTT (Terminal deoxynucleotidyl transferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNTT gene promoter:
         AML1a   AP-1   RREB-1   ATF-2   NF-AT   c-Ets-1   AREB6   CP2   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNTT promoter sequence
   Search SABiosciences Chromatin IP Primers for DNTT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNTT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23-q24

DNTT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNTT gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P098054:  view genomic region     (about GC identifiers)

Start:
98,064,085 bp from pter      End:
98,098,321 bp from pter
Size:
34,237 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TDT_HUMAN, P04053 (See protein sequence)
Recommended Name: DNA nucleotidylexotransferase  
Size: 509 amino acids; 58536 Da
Cofactor: Magnesium
Subunit: Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from
this complex by PCNA
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for DNTT:
2COE (3D)    
Secondary accessions: Q53FH1 Q5W103 Q96E50
Alternative splicing: 2 isoforms:  P04053-1   P04053-2   

Explore the universe of human proteins at neXtProt for DNTT: NX_P04053

Explore proteomics data for DNTT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04053

  • 4/9 DME Specific Peptides for DNTT (P04053) (see all 9)
     GHDVDFL  SQYACQR  DHFQKCF  DTEGIPCL 

    DNTT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNTT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017520.1  NP_004079.3  

    ENSEMBL proteins: 
     ENSP00000360216   ENSP00000401169  

    Human Recombinant Protein Products for DNTT: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DNTT 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    DNTT for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DNTT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    POL: DNA polymerases

    5/10 InterPro protein domains (see all 10):
     IPR001726 TdT/Mu
     IPR002934 Nucleotidyltransferase
     IPR027292 TdT
     IPR010996 DNA_pol_b-like_N
     IPR018944 DNA_pol_lambd_fingers_domain

    Graphical View of Domain Structure for InterPro Entry P04053

    ProtoNet protein and cluster: P04053

    5 Blocks protein domains:
    IPB001357 BRCT domain
    IPB001726 DNA nucleotidylexotransferase (TDT) signature
    IPB002008 DNA-polymerase family X pol beta-like signature
    IPB002054 DNA polymerase family X
    IPB002934 DNA polymerase


    UniProtKB/Swiss-Prot: TDT_HUMAN, P04053
    Similarity: Belongs to the DNA polymerase type-X family
    Similarity: Contains 1 BRCT domain


    DNTT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDT_HUMAN, P04053
    Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside
    5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of
    nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the
    maturation of B- and T-cells
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for DNTT:
    deoxynucleotidyltransferase,terminal

         Enzyme Numbers (IUBMB): EC 2.7.7.311 2 EC 2.7.72

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0003912DNA nucleotidylexotransferase activity IEA--
    GO:0016779nucleotidyltransferase activity ----
         
    DNTT for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dntt):
     cellular  hematopoietic system  immune system  normal 

    DNTT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DNTT: Dntttm1Fwa Dntttm1Gfn

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DNTT 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DNTT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Non-homologous end-joining
    Non-homologous end-joining0.46
    2Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    3Hematopoietic cell lineage
    Hematopoietic cell lineage

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DNTT
        Validated targets of C-MYC transcriptional repression


    2         Kegg Pathways  (Kegg details for DNTT):
        Non-homologous end-joining
    Hematopoietic cell lineage


    DNTT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNTT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for DNTT (P040533 ENSP000003602164) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNTTIP2Q5QJE63, ENSP000003521374I2D: score=2 STRING: ENSP00000352137
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    XRCC6P129563, ENSP000003522574I2D: score=2 STRING: ENSP00000352257
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process ----
    GO:0006304DNA modification IEA--

    DNTT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNTT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for DNTT

    Browse Tocris compounds for DNTT (TDT)

    3 HMDB Compounds for DNTT    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for DNTT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2',3'-Dideoxyadenosine-5'-Triphosphate-- --target--17139284 17016423 10592235

    10/55 Novoseek inferred chemical compound relationships for DNTT gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cd 79 75.2 4 17498589 (1), 18686384 (1), 19665353 (1), 12446447 (1)
    naphthol as-d chloroacetate 71 1 14692536 (1)
    paraffin 46.4 15 9343323 (5), 9227346 (2), 10233410 (1), 16454553 (1) (see all 9)
    sanguinarine 44.2 2 11770015 (1)
    dutp 43.8 10 10193519 (1), 15911970 (1), 18309685 (1), 19059832 (1) (see all 8)
    parathion 42.6 4 2162699 (3), 16212545 (1)
    fitc 41.5 9 9845437 (2), 7924695 (1), 16113043 (1), 7895530 (1) (see all 6)
    eb 1089 40.6 3 8903423 (1), 9846632 (1)
    bzatp 40.6 1 12899380 (1)
    propidium 38.1 1 9060958 (1)

    Search CenterWatch for drugs/clinical trials and news about DNTT / TDT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNTT gene (2 alternative transcripts): 
    NM_001017520.1  NM_004088.3  

    Unigene Cluster for DNTT:

    Deoxynucleotidyltransferase, terminal
    Hs.534206  [show with all ESTs]
    Unigene Representative Sequence: NM_004088
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371174 ENST00000419175(uc001kmf.3 uc001kmg.3)

    miRNA
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    Additional mRNA sequence: 

    AB046378.1 AK130771.1 AK223317.1 AK313615.1 BC012920.1 K01919.1 M26147.1 

    5 DOTS entries:

    DT.75163025  DT.114143  DT.100739794  DT.121216459  DT.100686314 

    21 AceView cDNA sequences:

    BP368640 AK130771 BX281386 CR597750 BM454641 AL558696 NM_004088 BX348525 
    BG392804 BP367885 AL559015 BP367455 BC012920 BX340469 K01919 AB046378 
    AA306371 BG258914 AW951054 M11722 AL580462 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DNTT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                -                                             


    ECgene alternative splicing isoforms for DNTT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNTT expression in normal human tissues (normalized intensities)      DNTT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATGACTG
    DNTT Expression
    About this image


    DNTT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/37 selected tissues (see all 37) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 17 entries
             Pro B-Cells Hematopoietic Bone Marrow
             Bone Marrow CD105+ Cells   
             bone marrow mononuclear cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 5 entries
             Double Negative 3 Thymocytes Thymus
             Thymus   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See DNTT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNTT

    SOURCE GeneReport for Unigene cluster: Hs.534206
        SABiosciences Expression via Pathway-Focused PCR Array including DNTT: 
              Lymphoma in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DNTT gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dntt1 , 5 deoxynucleotidyltransferase, terminal1, 5 80.55(n)1
    80.75(a)1
      19 (34.32 cM)5
    216731  NM_009345.21  NP_033371.21 
     410292755 
    chicken
    (Gallus gallus)
    Aves DNTT1 deoxynucleotidyltransferase, terminal 68.6(n)
    64.4(a)
      396351  NM_205389.1  NP_990720.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNTT6
    deoxynucleotidyltransferase, terminal
    62(a)
    1 ↔ 1
    GL343262.1(1035028-1194831)
    African clawed frog
    (Xenopus laevis)
    Amphibia dntt-A2 deoxynucleotidyltransferase, terminal 74.14(n)    U07803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dntt1 deoxynucleotidyltransferase, terminal 54.36(n)
    48.25(a)
      544653  NM_001014817.1  NP_001014817.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes POL46
    DNA polymerase IV, undergoes pair-wise interaction...
    14(a)
    1 → many
    III(139185-140933)


    ENSEMBL Gene Tree for DNTT (if available)
    TreeFam Gene Tree for DNTT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNTT gene
    POLB2  POLM2  POLL2  
    1 SIMAP similar gene for DNTT using alignment to 2 protein entries:     TDT_HUMAN (see all proteins):
    POLM

    DNTT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/885 SNPs in DNTT are shown (see all 885)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154459601,2
    F--98062096(+) GGGCAG/ACCTGA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1456835891,2
    --98062127(+) ACATCC/TCAGTA 2 -- us2k10--------
    rs1411616171,2
    --98062155(+) TTACT-/GCTTAG 2 -- us2k10--------
    rs788318341,2
    --98062201(+) GGAACA/GAACAC 2 -- us2k10--------
    rs741536221,2
    C,F--98062255(+) CTGCAG/ACACCA 2 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1426203721,2
    C--98062436(+) CCCTTC/TTGTTA 2 -- us2k10--------
    rs741536231,2
    C,F--98062486(+) TTTCAT/GGACTT 2 -- us2k12Minor allele frequency- G:0.10WA 120
    rs1178932451,2
    F--98062535(+) TTAGAC/TAGCTG 2 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1446462681,2
    --98062753(+) GGCCAG/TCCATG 2 -- us2k10--------
    rs1512472161,2
    --98062847(+) CAACAC/TGGTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNTT (98064085 - 98098321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNTT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831949CNV Gain17160897
    nsv831950CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 187410    OMIM disorders: --

    20/67 diseases for DNTT (see all 67):    About MalaCards
    acute non lymphoblastic leukemia    spiradenoma    acute biphenotypic leukemia    primary malignant lymphoma
    lymphoblastic lymphoma    adenosine deaminase deficiency    follicular dendritic cell tumor    acute leukemia
    gastrointestinal system disease    thymoma    childhood leukemia    merkel cell carcinoma
    thymic epithelial tumor    thymic carcinoma    lupus nephritis    mucoepidermoid carcinoma
    toxic encephalopathy    adenoid cystic carcinoma    burkitt's lymphoma    myelodysplastic syndromes

    8 diseases from the University of Copenhagen DISEASES database for DNTT:
    Vascular disease     Leukemia     Lymphoma     Brain disease
    Carcinoma     Eye disease     Heart disease     Gastrointestinal system disease

    DNTT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/52 Novoseek inferred disease relationships for DNTT gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma lymphoblastic 86.2 23 11190795 (2), 18480005 (2), 7937725 (2), 9042293 (2) (see all 16)
    lymphoblastic leukemia acute 77.1 22 9343323 (3), 7723388 (2), 16454553 (2), 16918360 (1) (see all 14)
    acute leukemia 76.2 25 7723388 (3), 1338518 (2), 18426728 (2), 7524307 (1) (see all 17)
    t-all 76.1 19 14961034 (3), 17430665 (2), 1698878 (2), 8152264 (1) (see all 11)
    leukemia 74.8 48 8371592 (2), 8709648 (2), 8366299 (2), 8555067 (2) (see all 39)
    leukaemia lymphocytic 64.9 13 17430665 (2), 8217792 (1), 8709648 (1), 9697877 (1) (see all 9)
    sarcoma granulocytic 63.8 2 7572794 (2)
    blast crisis 62.2 4 7924695 (1), 1996546 (1), 1592097 (1)
    b-all 61.8 3 17430665 (1), 8683996 (1), 17652839 (1)
    minimal residual disease 61.7 6 7723388 (1), 8555067 (1), 9576196 (1), 1836104 (1) (see all 5)

    Genetic Association Database (GAD): DNTT
    Human Genome Epidemiology (HuGE) Navigator: DNTT (1 document)

    Export disorders for DNTT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNTT gene, integrated from 9 sources (see all 372):
    (articles sorted by number of sources associating them with DNTT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. (PubMed id 8163485)1, 2, 9 Yang B.... Coleman M.S. (1994)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PubMed id 12786946)1, 2 Fujita K.... Koiwai O. (2003)
    5. Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389)1, 2 Mahajan K.N. and Mitchell B.S. (2003)
    6. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. (PubMed id 11473582)1, 2 Yamashita N.... Koiwai O. (2001)
    7. Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen. (PubMed id 11554927)1, 2 Ibe S....Koiwai O. (2001)
    8. Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene. (PubMed id 3395350)1, 2 Koiwai O. and Morita A. (1988)
    9. Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region. (PubMed id 2833741)1, 2 Riley L.K.... Coleman M.S. (1988)
    10. Expression of human terminal deoxynucleotidyl transferase in Escherichia coli. (PubMed id 2863268)1, 2 Peterson R.C....Bollum F.J. (1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1791 HGNC: 2983 AceView: DNTT Ensembl:ENSG00000107447 euGenes: HUgn1791
    ECgene: DNTT Kegg: 1791 H-InvDB: DNTT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNTT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNTT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNTT gene:
    Search GeneIP for patents involving DNTT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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