DNTT Gene protein-coding GIFtS : 65 GCID: GC10 P098054
DNA Nucleotidylexotransferase deoxynucleotidyltransferase, terminal )
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Aliasesfor DNTT gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section Aliases DNA Nucleotidylexotransferase 1 2 Terminal Transferase2 3 Terminal Deoxynucleotidyltransferase1 2 3 EC 2.7.7.313 8 TDT2 3 5 Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase2 Deoxynucleotidyltransferase, Terminal1 2 Terminal Deoxyribonucleotidyltransferase2 Terminal Addition Enzyme2 3 EC 2.7.78
Export aliases for DNTT gene to outside databases Previous GC identifers: GC10P096957 GC10P097297 GC10P098195 GC10P097728 GC10P091692
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Summariesfor DNTT gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DNTT Gene: This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase thatcatalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, theencoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytesduring early differentiation, where it generates antigen receptor diversity by synthesizing non-germ lineelements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments.Alternatively spliced transcript variants encoding different isoforms of this gene have been described. (providedby RefSeq, Jul 2008) GeneCards Summary for DNTT Gene: DNTT (DNA nucleotidylexotransferase) is a protein-coding gene. Diseases associated with DNTT include acute non lymphoblastic leukemia spiradenoma related super-pathways are Non-homologous end joining . GO annotations related to this gene include DNA nucleotidylexotransferase activity and DNA-directed DNA polymerase activity . An important paralog of this gene is POLB . UniProtKB/Swiss-Prot: TDT_HUMAN, P04053 Function : Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition ofnucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during thematuration of B- and T-cells Gene Wiki entry for DNTT (Terminal deoxynucleotidyl transferase) Gene
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Genomic Viewsfor DNTT gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 73) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.2 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DNTT gene promoter:AML1a AP-1 RREB-1 ATF-2 NF-AT c-Ets-1 AREB6 CP2 c-Jun NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for DNTT Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNTT
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q23-q24 Ensembl cytogenetic band: 10q24.1 HGNC cytogenetic band: 10q23-q24 DNTT Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P098054: view genomic region
(about GC identifiers )
Start: 98,064,085 bp from pter End:
98,098,321 bp from pter
Size: 34,237 bases Orientation:
plus strand
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Proteinsfor DNTT gene
(According to
UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MAXQB
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section UniProtKB/Swiss-Prot: TDT_HUMAN, P04053 See
protein sequence )Recommended Name: Size : 509 amino acids; 58536 DaCofactor : MagnesiumSubunit : Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released fromthis complex by PCNA
Subcellular location : Nucleus1 PDB 3D structure from :2COE (3D) Secondary accessions : Q53FH1 Q5W103 Q96E50Alternative splicing : 2 isoforms : P04053-1 P04053-2 Explore the universe of human proteins at neXtProt for DNTT: NX_P04053 Explore proteomics data for DNTT at MOPED Post-translational modifications:
View modification sites using PhosphoSitePlus View neXtProt modification sites for NX_P04053 4/9 DME Specific Peptides for DNTT (P04053 ) (see all 9 )DNTT Protein expression data from MOPED1 2 3 : About this image REFSEQ proteins (2 alternative transcripts): NP_001017520.1 NP_004079.3 ENSEMBL proteins: ENSP00000360216 ENSP00000401169 Human Recombinant Protein Products for DNTT: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing DNTT Antibody Products: Assay Products for DNTT:
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Protein
Domains /for DNTT gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section HGNC Gene Families: POL: DNA polymerases 5/10 InterPro protein domains (see all 10 ):
Graphical View of Domain Structure for InterPro Entry P04053 ProtoNet protein and cluster: P04053
5 Blocks protein domains : IPB001357 IPB001726 IPB002008 IPB002054 IPB002934 UniProtKB/Swiss-Prot: TDT_HUMAN, P04053 Similarity : Belongs to the DNA polymerase type-X familySimilarity : Contains 1 BRCT domainAbout GeneDecksing
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Functionfor DNTT gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
Vector BioLabs ,
and Sirion Biotech ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: TDT_HUMAN, P04053 Function : Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition ofnucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during thematuration of B- and T-cells Catalytic activity : Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Genatlas biochemistry entry for DNTT deoxynucleotidyltransferase,terminal Enzyme Numbers (IUBMB): EC 2.7.7.31 1 2 EC 2.7.7 2 Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA -- GO:0003824 catalytic activity
-- -- GO:0003887 DNA-directed DNA polymerase activity
IEA -- GO:0003912 DNA nucleotidylexotransferase activity
IEA -- GO:0016779 nucleotidyltransferase activity
-- --
About GeneDecksing Phenotypes: 4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dntt) :About GeneDecksing Animal Models: MGI mouse knock-outs for DNTT: Dntt tm1Fwa Dntt tm1Gfn Cell Line GenScript Custom overexpressing Cell Line Services for DNTT Search LifeMap BioReagents cell lines for DNTT In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT
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Pathways & Interactionsfor DNTT gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene) .
About This Section SuperPaths for DNTT About See pathways by source SuperPath Contained pathways About 1 Non-homologous end-joining 2 Validated targets of C-MYC transcriptional repression 3 Hematopoietic cell lineage
Pathways by source See SuperPaths Show all pathways 1 2 (Kegg details for DNTT) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNTT STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)5/19 Interacting proteins for DNTT (P04053 3 ENSP00000360216 4 via UniProtKB, MINT, STRING , and/or I2D (see all 19 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006259 DNA metabolic process
-- -- GO:0006304 DNA modification
IEA --
About GeneDecksing
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Drugs & Compoundsfor DNTT gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for DNTT
Browse Tocris compounds for DNTT (TDT) 3 HMDB Compounds for DNTT About this table 1 DrugBank Compound for DNTT About this table 10/55 Novoseek inferred chemical compound relationships for DNTT gene (see all 55 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
cd 79
75.2
4
17498589 (1), 18686384 (1), 19665353 (1), 12446447 (1)
naphthol as-d chloroacetate
71
1
14692536 (1)
paraffin
46.4
15
9343323 (5), 9227346 (2), 10233410 (1), 16454553 (1) (see
all 9 )
sanguinarine
44.2
2
11770015 (1)
dutp
43.8
10
10193519 (1), 15911970 (1), 18309685 (1), 19059832 (1) (see
all 8 )
parathion
42.6
4
2162699 (3), 16212545 (1)
fitc
41.5
9
9845437 (2), 7924695 (1), 16113043 (1), 7895530 (1) (see
all 6 )
eb 1089
40.6
3
8903423 (1), 9846632 (1)
bzatp
40.6
1
12899380 (1)
propidium
38.1
1
9060958 (1)
DNTT / TDT
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Transcriptsfor DNTT gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Sirion Biotech ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DNTT gene (2 alternative transcripts): NM_001017520.1 NM_004088.3 Unigene Cluster for DNTT:
Deoxynucleotidyltransferase, terminal Hs.534206 [show with all ESTs ] Unigene Representative Sequence: NM_004088 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000371174 ENST00000419175 (uc001kmf.3 uc001kmg.3 ) Primer DNTT human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat
Additional mRNA sequence: AB046378.1 AK130771.1 AK223317.1 AK313615.1 BC012920.1 K01919.1 M26147.1
5 DOTS entries : DT.75163025 DT.114143
DT.100739794 DT.121216459 DT.100686314 21 AceView cDNA sequences :
BP368640 AK130771 BX281386 CR597750 BM454641 AL558696 NM_004088 BX348525 BG392804 BP367885 AL559015 BP367455 BC012920 BX340469 K01919 AB046378 AA306371 BG258914 AW951054 M11722 AL580462 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for DNTT About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b SP1 : SP2 : SP3 : -
ECgene alternative splicing isoforms for DNTT
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Expression for DNTT gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DNTT expression in normal human tissues
(normalized intensities) DNTT embryonic expression: see See probesets specificity/sensitivity at GeneAnnot About this image BioGPS 2/3 CGAP TAG: TTTATGACTGAbout this image
DNTT expression in embryonic tissues and stem cells About this table LifeMap ,
the Embryonic Development and Stem Cells Database 5/37 selected tissues (see all 37 ) fully expand See DNTT Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DNTT SOURCE GeneReport for Unigene cluster: Hs.534206 SABiosciences Expression via Pathway-Focused PCR Array including DNTT : Primer DNTT human mouse SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT
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Orthologsfor DNTT gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for DNTT gene from 6/14 species (see all 14 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Dntt1 5
deoxynucleotidyltransferase, terminal1, 5
80.55(n) 1 80.75(a) 1
19 (34.32 cM) 5 21673 1 NM_009345.2 1 NP_033371.2 1 41029275 5
chicken Aves DNTT1
deoxynucleotidyltransferase, terminal
68.6(n) 64.4(a)
396351 NM_205389.1 NP_990720.1
lizard Reptilia DNTT6
deoxynucleotidyltransferase, terminal
62(a)
1 ↔ 1
GL343262.1(1035028-1194831)
African clawed frog Amphibia dntt-A2
deoxynucleotidyltransferase, terminal
74.14(n)
U07803.1
zebrafish Actinopterygii dntt1
deoxynucleotidyltransferase, terminal
54.36(n) 48.25(a)
544653 NM_001014817.1 NP_001014817.1
baker's yeast Saccharomycetes POL46
DNA polymerase IV, undergoes pair-wise interaction... 14(a)
1 → many
III(139185-140933)
ENSEMBL Gene Tree for DNTT (if available)TreeFam Gene Tree for DNTT (if available)
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Paralogsfor DNTT gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DNTT gene POLB 2 POLM 2 POLL 2 1 SIMAP similar gene for DNTT using alignment to 2 protein entries: TDT_HUMAN (see all proteins ):POLM About GeneDecksing
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Genomic Variantsfor DNTT gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 10 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for DNTT (98064085 - 98098321 bp)
Structural Variations Database of Genomic Variants (DGV) 2 variations for DNTT : About this table SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor DNTT gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Novoseek , Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section OMIM gene information: 187410
OMIM disorders : --20/67 (see all 67 ): About MalaCards acute non lymphoblastic leukemia spiradenoma acute biphenotypic leukemia primary malignant lymphoma lymphoblastic lymphoma adenosine deaminase deficiency follicular dendritic cell tumor acute leukemia gastrointestinal system disease thymoma childhood leukemia merkel cell carcinoma thymic epithelial tumor thymic carcinoma lupus nephritis mucoepidermoid carcinoma toxic encephalopathy adenoid cystic carcinoma burkitt's lymphoma myelodysplastic syndromes 8 diseases from the University of Copenhagen DISEASES database for DNTT :Vascular disease Leukemia Lymphoma Brain disease Carcinoma Eye disease Heart disease Gastrointestinal system disease About GeneDecksing Congresses - knowledge worth sharing: Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015 10/52 Novoseek inferred disease relationships for DNTT gene (see all 52 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma lymphoblastic
86.2
23
11190795 (2), 18480005 (2), 7937725 (2), 9042293 (2) (see
all 16 )
lymphoblastic leukemia acute
77.1
22
9343323 (3), 7723388 (2), 16454553 (2), 16918360 (1) (see
all 14 )
acute leukemia
76.2
25
7723388 (3), 1338518 (2), 18426728 (2), 7524307 (1) (see
all 17 )
t-all
76.1
19
14961034 (3), 17430665 (2), 1698878 (2), 8152264 (1) (see
all 11 )
leukemia
74.8
48
8371592 (2), 8709648 (2), 8366299 (2), 8555067 (2) (see
all 39 )
leukaemia lymphocytic
64.9
13
17430665 (2), 8217792 (1), 8709648 (1), 9697877 (1) (see
all 9 )
sarcoma granulocytic
63.8
2
7572794 (2)
blast crisis
62.2
4
7924695 (1), 1996546 (1), 1592097 (1)
b-all
61.8
3
17430665 (1), 8683996 (1), 17652839 (1)
minimal residual disease
61.7
6
7723388 (1), 8555067 (1), 9576196 (1), 1836104 (1) (see
all 5 )
Genetic Association Database (GAD): DNTT Human Genome Epidemiology (HuGE) Navigator: DNTT (1 document)Export disorders for DNTT gene to outside databases
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Publicationsfor DNTT gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DNTT gene, integrated from 9 sources (see all 372 ):(articles sorted by number of sources associating them with DNTT) Utopia : connect your pdf to the dynamic
Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. (PubMed id 8163485) 1 , 2 , 9(1994) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451) 1 , 4(2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PubMed id 12786946) 1 , 2 (2003) Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389) 1 , 2 (2003) Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. (PubMed id 11473582) 1 , 2 (2001) Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen. (PubMed id 11554927) 1 , 2 (2001) Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene. (PubMed id 3395350) 1 , 2 (1988) Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region. (PubMed id 2833741) 1 , 2 (1988) Expression of human terminal deoxynucleotidyl transferase in Escherichia coli. (PubMed id 2863268) 1 , 2 (1985)
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External Searches for DNTT gene
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Genome Databases showing DNTT gene
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Specialized Databases showing DNTT gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DNTT gene: DNTT GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DNTT gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Sirion Biotech , Cell lines from GenScript , and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNTT QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNTT QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT
ThermoFisher Antibody for DNTT
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DNTT
LSBio Antibodies in human mouse rat
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