Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNTT Gene

Aliases for DNTT Gene

  • DNA Nucleotidylexotransferase 2 3
  • Terminal Deoxynucleotidyltransferase 2 3 4
  • TDT 3 4 6
  • Deoxynucleotidyltransferase, Terminal 2 3
  • Terminal Addition Enzyme 3 4
  • Terminal Transferase 3 4
  • EC 2.7.7.31 4 63
  • Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase 3
  • Terminal Deoxyribonucleotidyltransferase 3
  • EC 2.7.7 63

External Ids for DNTT Gene

Previous GeneCards Identifiers for DNTT Gene

  • GC10P096957
  • GC10P097297
  • GC10P098195
  • GC10P097728
  • GC10P098054
  • GC10P091692
  • GC10P098072

Summaries for DNTT Gene

Entrez Gene Summary for DNTT Gene

  • This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNTT Gene

DNTT (DNA Nucleotidylexotransferase) is a Protein Coding gene. Diseases associated with DNTT include spiradenoma and adenosine deaminase deficiency. Among its related pathways are Validated targets of C-MYC transcriptional repression and Hematopoietic cell lineage. GO annotations related to this gene include DNA-directed DNA polymerase activity and DNA nucleotidylexotransferase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot for DNTT Gene

  • Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5-triphosphate to the 3-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Gene Wiki entry for DNTT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNTT Gene

Genomics for DNTT Gene

Regulatory Elements for DNTT Gene

Genomic Location for DNTT Gene

Start:
96,304,328 bp from pter
End:
96,338,564 bp from pter
Size:
34,237 bases
Orientation:
Plus strand

Genomic View for DNTT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNTT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNTT Gene

Proteins for DNTT Gene

  • Protein details for DNTT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04053-TDT_HUMAN
    Recommended name:
    DNA nucleotidylexotransferase
    Protein Accession:
    P04053
    Secondary Accessions:
    • Q53FH1
    • Q5W103
    • Q96E50

    Protein attributes for DNTT Gene

    Size:
    509 amino acids
    Molecular mass:
    58536 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).;
    Quaternary structure:
    • Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA. Interacts with TRERF1 (PubMed:16371131).

    Three dimensional structures from OCA and Proteopedia for DNTT Gene

    Alternative splice isoforms for DNTT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNTT Gene

Proteomics data for DNTT Gene at MOPED

Post-translational modifications for DNTT Gene

  • Ubiquitination at Lys59, Lys199, Lys209, Lys222, Lys250, Lys261, Lys290, Lys339, Lys371, Lys386, Lys393, Lys408, Lys425, and Lys468
  • Modification sites at PhosphoSitePlus

Other Protein References for DNTT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DNTT Gene

Gene Families for DNTT Gene

HGNC:
  • POL :DNA polymerases

Suggested Antigen Peptide Sequences for DNTT Gene

Graphical View of Domain Structure for InterPro Entry

P04053

UniProtKB/Swiss-Prot:

TDT_HUMAN :
  • P04053
Domain:
  • Contains 1 BRCT domain.
Family:
  • Belongs to the DNA polymerase type-X family.
genes like me logo Genes that share domains with DNTT: view

Function for DNTT Gene

Molecular function for DNTT Gene

GENATLAS Biochemistry: deoxynucleotidyltransferase,terminal
UniProtKB/Swiss-Prot CatalyticActivity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
UniProtKB/Swiss-Prot Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5-triphosphate to the 3-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Enzyme Numbers (IUBMB) for DNTT Gene

Gene Ontology (GO) - Molecular Function for DNTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003887 DNA-directed DNA polymerase activity IEA --
GO:0003912 DNA nucleotidylexotransferase activity IDA 11473582
GO:0005515 protein binding IPI 11473582
GO:0016779 nucleotidyltransferase activity --
genes like me logo Genes that share ontologies with DNTT: view

Phenotypes for DNTT Gene

genes like me logo Genes that share phenotypes with DNTT: view

Animal Models for DNTT Gene

MGI Knock Outs for DNTT:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNTT

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for DNTT Gene

Localization for DNTT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNTT Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNTT Gene COMPARTMENTS Subcellular localization image for DNTT gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 3
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
plasma membrane 2
vacuole 2

Gene Ontology (GO) - Cellular Components for DNTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16371131
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DNTT: view

Pathways for DNTT Gene

genes like me logo Genes that share pathways with DNTT: view

Pathways by source for DNTT Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DNTT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006259 DNA metabolic process IDA 11473582
GO:0006304 DNA modification IEA --
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with DNTT: view

Compounds for DNTT Gene

(3) HMDB Compounds for DNTT Gene

Compound Synonyms Cas Number PubMed IDs
Magnesium
  • Magnesium
7439-95-4
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for DNTT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2',3'-Dideoxyadenosine-5'-Triphosphate
target

(55) Novoseek inferred chemical compound relationships for DNTT Gene

Compound -log(P) Hits PubMed IDs
cd 79 75.2 4
naphthol as-d chloroacetate 71 1
paraffin 46.4 14
sanguinarine 44.2 1
dutp 43.8 8
genes like me logo Genes that share compounds with DNTT: view

Transcripts for DNTT Gene

mRNA/cDNA for DNTT Gene

(3) REFSEQ mRNAs :
(21) Selected AceView cDNA sequences:
(7) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DNTT Gene

Deoxynucleotidyltransferase, terminal:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNTT

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNTT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2:
SP3: -

Relevant External Links for DNTT Gene

GeneLoc Exon Structure for
DNTT
ECgene alternative splicing isoforms for
DNTT

Expression for DNTT Gene

mRNA expression in normal human tissues for DNTT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DNTT Gene

This gene is overexpressed in Testis (16.5) and Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNTT Gene

SOURCE GeneReport for Unigene cluster for DNTT Gene Hs.534206

genes like me logo Genes that share expressions with DNTT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DNTT Gene

Orthologs for DNTT Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNTT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DNTT 35
  • 99.21 (n)
  • 99.41 (a)
DNTT 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DNTT 35
  • 89.39 (n)
  • 86.44 (a)
DNTT 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNTT 35
  • 87.27 (n)
  • 86.02 (a)
DNTT 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dntt 35
  • 80.55 (n)
  • 80.75 (a)
Dntt 16
Dntt 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNTT 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DNTT 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dntt 35
  • 81.01 (n)
  • 82.51 (a)
chicken
(Gallus gallus)
Aves DNTT 35
  • 68.6 (n)
  • 64.4 (a)
DNTT 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNTT 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dntt-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dntt 35
  • 61.97 (n)
  • 57.35 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11749 35
zebrafish
(Danio rerio)
Actinopterygii dntt 35
  • 54.5 (n)
  • 48.25 (a)
dntt 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for DNTT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNTT Gene

ENSEMBL:
Gene Tree for DNTT (if available)
TreeFam:
Gene Tree for DNTT (if available)

Paralogs for DNTT Gene

Paralogs for DNTT Gene

Selected SIMAP similar genes for DNTT Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DNTT: view

Variants for DNTT Gene

Sequence variations from dbSNP and Humsavar for DNTT Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs734225 -- 96,317,357(+) ATGGC(C/T)AATGC intron-variant
rs734226 -- 96,317,405(+) AGATC(C/T)CTGTC intron-variant
rs941993 -- 96,324,980(-) TAGGC(G/T)AAAGA intron-variant
rs941994 -- 96,324,958(-) GTATA(C/T)CAACC intron-variant
rs941995 -- 96,324,646(-) CATTA(A/T)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DNTT Gene

Variant ID Type Subtype PubMed ID
nsv831949 CNV Gain 17160897
nsv831950 CNV Gain 17160897

Relevant External Links for DNTT Gene

HapMap Linkage Disequilibrium report
DNTT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNTT Gene

Disorders for DNTT Gene

(52) Novoseek inferred disease relationships for DNTT Gene

Disease -log(P) Hits PubMed IDs
lymphoma lymphoblastic 86.2 20
lymphoblastic leukemia acute 77.1 18
acute leukemia 76.2 21
t-all 76.1 15
leukemia 74.8 43

Relevant External Links for DNTT

Genetic Association Database (GAD)
DNTT
Human Genome Epidemiology (HuGE) Navigator
DNTT
genes like me logo Genes that share disorders with DNTT: view

No data available for UniProtKB/Swiss-Prot for DNTT Gene

Publications for DNTT Gene

  1. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. (PMID: 8163485) Yang B. … Coleman M.S. (J. Biol. Chem. 1994) 3 4 23
  2. Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity. (PMID: 17663723) Kubota T. … Koiwai O. (Genes Cells 2007) 3 23
  3. Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase. (PMID: 18429817) Maezawa S. … Koiwai O. (Genes Cells 2008) 3 23
  4. TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm. (PMID: 19930467) Hayano T. … Koiwai O. (Genes Cells 2009) 3 23
  5. Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region. (PMID: 2833741) Riley L.K. … Coleman M.S. (Proc. Natl. Acad. Sci. U.S.A. 1988) 3 4

Products for DNTT Gene

Sources for DNTT Gene

Back to Top

Content