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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNTT Gene

protein-coding   GIFtS: 63
GCID: GC10P098054

deoxynucleotidyltransferase, terminal
 Explore 75 diseases affiliated with
DNTT via
MalaCards
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 Human Malady Compendium 
Biological research products
for DNTT    

Aliases
for DNTT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Deoxynucleotidyltransferase, Terminal1 2     EC 2.7.7.313 8
TDT1 2 3 5     DNA Nucleotidylexotransferase2
Terminal Addition Enzyme2 3     Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase2
Terminal Deoxynucleotidyltransferase2 3     Terminal Deoxyribonucleotidyltransferase2
Terminal Transferase2 3     EC 2.7.78

External Ids:    HGNC: 29831   Entrez Gene: 17912   Ensembl: ENSG000001074477   OMIM: 1874105   UniProtKB: P040533   

Export aliases for DNTT gene to outside databases

Previous GC identifers: GC10P096957 GC10P097297 GC10P098195 GC10P097728 GC10P091692


Summaries
for DNTT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DNTT:
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that
catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the
encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during
early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements
(N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced
transcript variants encoding different isoforms of this gene have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TDT_HUMAN, P04053
Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to
the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the
junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and
T-cells

Gene Wiki entry for DNTT (Terminal deoxynucleotidyl transferase)


Genomic Views
for DNTT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNTT gene promoter:
         AML1a   AP-1   RREB-1   ATF-2   NF-AT   c-Ets-1   AREB6   CP2   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNTT promoter sequence
   Search SABiosciences Chromatin IP Primers for DNTT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNTT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23-q24

DNTT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNTT gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P098054:  view genomic region     (about GC identifiers)

Start:
 98,064,085 bp from pter      End:
 98,098,321 bp from pter
Size:
 34,237 bases      Orientation:
 plus strand

Proteins
for DNTT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TDT_HUMAN, P04053 (See protein sequence)
Recommended Name: DNA nucleotidylexotransferase  
Size: 509 amino acids; 58536 Da
Cofactor: Magnesium
Subunit: Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from this
complex by PCNA
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for DNTT:
2COE (3D)    
Secondary accessions: Q53FH1 Q5W103 Q96E50
Alternative splicing: 2 isoforms:  P04053-1   P04053-2   

Explore the universe of human proteins at neXtProt for DNTT: NX_P04053

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04053

    • 4/9 DME Specific Peptides for DNTT (P04053) (see all 9)
     GHDVDFL  SQYACQR  DHFQKCF  DTEGIPCL 

    DNTT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017520.1  NP_004079.3  

    ENSEMBL proteins: 
     ENSP00000360216   ENSP00000401169  

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    Novus Biologicals DNTT Protein
    Novus Biologicals DNTT Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DNTT

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    DNTT for ontologies           About GeneDecksing



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    Uscn Antibodies for DNTT
    ThermoFisher Antibodies for DNTT

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    Uscn ELISAs and CLIAs for DNTT

    Protein Domains /
    Families
    for DNTT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DNTT for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR001726 TdT/Mu
     IPR002934 Nucleotidyltransferase
     IPR010996 DNA_pol_b-like_N
     IPR018944 DNA_pol_lambd_fingers_domain
     IPR019843 DNA_pol-X_BS

    Graphical View of Domain Structure for InterPro Entry P04053

    ProtoNet protein and cluster: P04053

    5 Blocks protein families:
    IPB001357 BRCT domain
    IPB001726 DNA nucleotidylexotransferase (TDT) signature
    IPB002008 DNA-polymerase family X pol beta-like signature
    IPB002054 DNA polymerase family X
    IPB002934 DNA polymerase


    UniProtKB/Swiss-Prot: TDT_HUMAN, P04053
    Similarity: Belongs to the DNA polymerase type-X family
    Similarity: Contains 1 BRCT domain


    Function
    for DNTT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TDT_HUMAN, P04053
    Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to
    the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the
    junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and
    T-cells
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for DNTT:
    deoxynucleotidyltransferase,terminal

    Enzyme Numbers (IUBMB): EC 2.7.7.311 2 EC 2.7.72

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0003912DNA nucleotidylexotransferase activity IEA--
    GO:0046872metal ion binding IEA--


    DNTT for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for DNTT: Dntttm1Fwa Dntttm1Gfn
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dntt):
     cellular  hematopoietic system  immune system  normal 

    DNTT for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DNTT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Validated targets of C-MYC transcriptional repression
    		Validated targets of C-MYC transcriptional repression1.00
    2Hematopoietic cell lineage
    		Hematopoietic cell lineage1.00
    3Non-homologous end-joining
    		Non-homologous end-joining1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for DNTT 
        Validated targets of C-MYC transcriptional repression


    2         Kegg Pathways  (Kegg details for DNTT):
        Non-homologous end-joining
    Hematopoietic cell lineage


    DNTT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNTT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for DNTT (P040533 ENSP000003602164) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNTTIP2Q5QJE63, ENSP000003521374I2D: score=2 STRING: ENSP00000352137
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    XRCC6P129563, ENSP000003522574I2D: score=2 STRING: ENSP00000352257
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process ----
    GO:0006304DNA modification IEA--


    DNTT for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNTT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNTT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for DNTT

    Browse Tocris compounds for DNTT

    3 HMDB Compounds for DNTT    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for DNTT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2',3'-Dideoxyadenosine-5'-Triphosphate-- --target--17139284 17016423 10592235

    10/55 Novoseek chemical compound relationships for DNTT gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cd 79 75.2 4 17498589 (1), 18686384 (1), 19665353 (1), 12446447 (1)
    naphthol as-d chloroacetate 71 1 14692536 (1)
    paraffin 46.4 15 9343323 (5), 9227346 (2), 10233410 (1), 16454553 (1) (see all 9)
    sanguinarine 44.2 2 11770015 (1)
    dutp 43.8 10 10193519 (1), 15911970 (1), 18309685 (1), 19059832 (1) (see all 8)
    parathion 42.6 4 2162699 (3), 16212545 (1)
    fitc 41.5 9 9845437 (2), 7924695 (1), 16113043 (1), 7895530 (1) (see all 6)
    eb 1089 40.6 3 8903423 (1), 9846632 (1)
    bzatp 40.6 1 12899380 (1)
    propidium 38.1 1 9060958 (1)

    Search CenterWatch for drugs/clinical trials and news about DNTT / TDT 

    Transcripts
    for DNTT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNTT gene (2 alternative transcripts): 
    NM_001017520.1  NM_004088.3  

    Unigene Cluster for DNTT:

    Deoxynucleotidyltransferase, terminal
    Hs.534206  [show with all ESTs]
    Unigene Representative Sequence: NM_004088
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371174 ENST00000419175(uc001kmf.3 uc001kmg.3)

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNTT (see all 6)
    OriGene siRNA: DNTT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNTT
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DNTT (NM_004088)
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    Primer
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    Additional cDNA sequence: 

    AB046378.1 AK130771.1 AK223317.1 AK313615.1 BC012920.1 K01919.1 M26147.1 

    5 DOTS entries:

    DT.75163025  DT.114143  DT.100739794  DT.121216459  DT.100686314 

    21 AceView cDNA sequences:

    AK130771 BX281386 CR597750 BP368640 K01919 BP367455 NM_004088 AL558696 
    BP367885 BX348525 BC012920 BM454641 AL559015 BG392804 AB046378 BX340469 
    AW951054 BG258914 AA306371 M11722 AL580462 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DNTT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                -                                             


    ECgene alternative splicing isoforms for DNTT

    Expression
    for DNTT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNTT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTATGACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DNTT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodPro-B CellsBlood
    BloodPeripheral BloodImmature B CellsBlood
    BloodPeripheral BloodPre-B CellsBlood
    BloodPeripheral BloodB-cell Progenitor CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DNTT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNTT

    SOURCE GeneReport for Unigene cluster: Hs.534206
        SABiosciences Expression via Pathway-Focused PCR Array including DNTT: 
              Lymphoma in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT

    Orthologs
    for DNTT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNTT gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DNTT1 deoxynucleotidyltransferase, terminal 68.6(n)
    64.4(a)    		   396351  NM_205389.1  NP_990720.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DNTT6
    		 --
    		 59(a)
    		 1 ↔ 1
    		 GL343262.1(1066288-1194831)
    African clawed frog
    (Xenopus laevis)    		 Amphibia dntt-A2 deoxynucleotidyltransferase, terminal 74.14(n)    U07803.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dntt1 deoxynucleotidyltransferase, terminal 54.36(n)
    48.25(a)    		   544653  NM_001014817.1  NP_001014817.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G105206
    		 DNA polymerase lambda subunit
    		 20(a)
    		 1 → many
    		 1(3465964-3469248)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 DNA polymerase lambda, putative, expressed
    		 21(a)
    		 1 → many
    		 6(7127120-7132516)


    ENSEMBL Gene Tree for DNTT (if available)
    TreeFam Gene Tree for DNTT (if available) 

    Paralogs
    for DNTT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNTT gene
    POLB2  POLM2  POLL2  
    1 SIMAP similar gene for DNTT using alignment to 2 protein entries:     TDT_HUMAN (see all proteins):
    POLM

    DNTT for paralogs           About GeneDecksing



    Genomic Variants
    for DNTT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/742 NCBI SNPs in DNTT are shown (see all 742)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1154459601,2
    		F,--98062096(+) GGGCAG/ACCTGA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1456835891,2
    		--98062127(+) ACATCC/TCAGTA 2 -- us2k10--------
    rs1411616171,2
    		--98062155(+) TTACT-/GCTTAG 2 -- us2k10--------
    rs788318341,2
    		--98062201(+) GGAACA/GAACAC 2 -- us2k10--------
    rs741536221,2
    		C,--98062255(+) CTGCAG/ACACCA 2 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1426203721,2
    		--98062436(+) CCCTTC/TTGTTA 2 -- us2k10--------
    rs741536231,2
    		C,--98062486(+) TTTCAT/GGACTT 2 -- us2k12Minor allele frequency- G:0.10WA 120
    rs1178932451,2
    		F,--98062535(+) TTAGAC/TAGCTG 2 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1446462681,2
    		--98062753(+) GGCCAG/TCCATG 2 -- us2k10--------
    rs1512472161,2
    		--98062847(+) CAACAC/TGGTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNTT (98064085 - 98098321 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DNTT: --

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    Disorders / Diseases
    for DNTT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DNTT for disorders           About GeneDecksing

    OMIM gene information: 187410    OMIM disorders: --

    20/75 diseases for DNTT (see all 75):    About MalaCards
    adenosine deaminase deficiency    dna topoisomerase i    follicular dendritic cell tumor    acute biphenotypic leukemia
    primitive neuroectodermal tumor    lymphoblastic leukemia    thymic epithelial tumor    acute non lymphoblastic leukemia
    myeloid leukemia    lupus nephritis    burkitt's lymphoma    leukemia
    b-cell lymphomas    neuroectodermal tumors    toxic encephalopathy    frontotemporal dementia
    adenoid cystic carcinoma    spiradenoma    mantle cell lymphoma    merkel cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for DNTT:
    Leukemia

    10/52 Novoseek disease relationships for DNTT gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma lymphoblastic 86.2 23 11190795 (2), 18480005 (2), 7937725 (2), 9042293 (2) (see all 16)
    lymphoblastic leukemia acute 77.1 22 9343323 (3), 7723388 (2), 16454553 (2), 16918360 (1) (see all 14)
    acute leukemia 76.2 25 7723388 (3), 1338518 (2), 18426728 (2), 7524307 (1) (see all 17)
    t-all 76.1 19 14961034 (3), 17430665 (2), 1698878 (2), 8152264 (1) (see all 11)
    leukemia 74.8 48 8371592 (2), 8709648 (2), 8366299 (2), 8555067 (2) (see all 39)
    leukaemia lymphocytic 64.9 13 17430665 (2), 8217792 (1), 8709648 (1), 9697877 (1) (see all 9)
    sarcoma granulocytic 63.8 2 7572794 (2)
    blast crisis 62.2 4 7924695 (1), 1996546 (1), 1592097 (1)
    b-all 61.8 3 17430665 (1), 8683996 (1), 17652839 (1)
    minimal residual disease 61.7 6 7723388 (1), 8555067 (1), 9576196 (1), 1836104 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: DNTT (1 document)

    Export disorders for DNTT gene to outside databases

    Publications
    for DNTT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNTT gene, integrated from 9 sources (see all 370):
    (articles sorted by number of sources associating them with DNTT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. (PubMed id 8163485)1, 2, 9 Yang B.... Coleman M.S. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PubMed id 12786946)1, 2 Fujita K.... Koiwai O. (2003)
    4. Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389)1, 2 Mahajan K.N. and Mitchell B.S. (2003)
    5. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. (PubMed id 11473582)1, 2 Yamashita N.... Koiwai O. (2001)
    6. Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen. (PubMed id 11554927)1, 2 Ibe S....Koiwai O. (2001)
    7. Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene. (PubMed id 3395350)1, 2 Koiwai O. and Morita A. (1988)
    8. Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region. (PubMed id 2833741)1, 2 Riley L.K.... Coleman M.S. (1988)
    9. Expression of human terminal deoxynucleotidyl transferase in Escherichia coli. (PubMed id 2863268)1, 2 Peterson R.C....Bollum F.J. (1985)
    10. Molecular cloning of human terminal deoxynucleotidyltransferase. (PubMed id 6087320)1, 2 Peterson R.C....Bollum F.J. (1984)

    External Searches for DNTT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DNTT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1791 HGNC: 2983 AceView: DNTT Ensembl:ENSG00000107447 euGenes: HUgn1791
    ECgene: DNTT Kegg: 1791 H-InvDB: DNTT

    Other Databases showing DNTT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DNTT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNTT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNTT Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DNTT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNTT gene:
    Search GeneIP for patents involving DNTT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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