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DNTT Gene

protein-coding   GIFtS: 65
GCID: GC10P098072

DNA Nucleotidylexotransferase

(Previous names: deoxynucleotidyltransferase, terminal)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNA Nucleotidylexotransferase1 2     Terminal Transferase2 3
Terminal Deoxynucleotidyltransferase1 2 3     EC 2.7.7.313 8
TDT2 3 5     Nucleosidetriphosphate:DNA Deoxynucleotidylexotransferase2
Deoxynucleotidyltransferase, Terminal1 2     Terminal Deoxyribonucleotidyltransferase2
Terminal Addition Enzyme2 3     EC 2.7.78

External Ids:    HGNC: 29831   Entrez Gene: 17912   Ensembl: ENSG000001074477   OMIM: 1874105   UniProtKB: P040533   

Export aliases for DNTT gene to outside databases

Previous GC identifers: GC10P096957 GC10P097297 GC10P098195 GC10P097728 GC10P098054 GC10P091692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNTT Gene:
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that
catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the
encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes
during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line
elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments.
Alternatively spliced transcript variants encoding different isoforms of this gene have been described. (provided
by RefSeq, Jul 2008)

GeneCards Summary for DNTT Gene:
DNTT (DNA nucleotidylexotransferase) is a protein-coding gene. Diseases associated with DNTT include acute non lymphoblastic leukemia, and acute biphenotypic leukemia. GO annotations related to this gene include DNA nucleotidylexotransferase activity and DNA-directed DNA polymerase activity. An important paralog of this gene is POLB.

UniProtKB/Swiss-Prot: TDT_HUMAN, P04053
Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside
5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of
nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the
maturation of B- and T-cells

Gene Wiki entry for DNTT (Terminal deoxynucleotidyl transferase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNTT gene promoter:
         AML1a   AP-1   RREB-1   ATF-2   NF-AT   c-Ets-1   AREB6   CP2   c-Jun   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNTT promoter sequence
   Search Chromatin IP Primers for DNTT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNTT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23-q24   Ensembl cytogenetic band:  10q24.1   HGNC cytogenetic band: 10q23-q24

DNTT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNTT gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P098072:  view genomic region     (about GC identifiers)

Start:
98,064,085 bp from pter      End:
98,098,321 bp from pter
Size:
34,237 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TDT_HUMAN, P04053 (See protein sequence)
Recommended Name: DNA nucleotidylexotransferase  
Size: 509 amino acids; 58536 Da
Cofactor: Magnesium
Subunit: Interacts with PRP19 and DNTTIP1. Forms a ternary complex with DNTTIP2 and core histone. Released from
this complex by PCNA
1 PDB 3D structure from and Proteopedia for DNTT:
2COE (3D)    
Secondary accessions: Q53FH1 Q5W103 Q96E50
Alternative splicing: 2 isoforms:  P04053-1   P04053-2   

Explore the universe of human proteins at neXtProt for DNTT: NX_P04053

Explore proteomics data for DNTT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys199, Lys209, Lys222, Lys250, Lys261, Lys290, Lys339, Lys371, Lys386,
                                 Lys393, Lys408, Lys425, Lys468
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DNTT (P04053) (see all 9)
     GHDVDFL  SQYACQR  DHFQKCF  DTEGIPCL 


    See DNTT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017520.1  NP_004079.3  

    ENSEMBL proteins: 
     ENSP00000360216   ENSP00000401169  

    DNTT Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for DNTT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    POL: DNA polymerases

    Selected InterPro protein domains (see all 10):
     IPR001726 TdT/Mu
     IPR002934 Nucleotidyltransferase
     IPR027292 TdT
     IPR010996 DNA_pol_b-like_N
     IPR018944 DNA_pol_lambd_fingers_domain

    Graphical View of Domain Structure for InterPro Entry P04053

    ProtoNet protein and cluster: P04053

    5 Blocks protein domains:
    IPB001357 BRCT domain
    IPB001726 DNA nucleotidylexotransferase (TDT) signature
    IPB002008 DNA-polymerase family X pol beta-like signature
    IPB002054 DNA polymerase family X
    IPB002934 DNA polymerase


    UniProtKB/Swiss-Prot: TDT_HUMAN, P04053
    Similarity: Belongs to the DNA polymerase type-X family
    Similarity: Contains 1 BRCT domain


    DNTT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TDT_HUMAN, P04053
    Function: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside
    5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of
    nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the
    maturation of B- and T-cells
    Catalytic activity: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

         Genatlas biochemistry entry for DNTT:
    deoxynucleotidyltransferase,terminal

         Enzyme Numbers (IUBMB): EC 2.7.7.311 2 EC 2.7.72

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0003887DNA-directed DNA polymerase activity IEA--
    GO:0003912DNA nucleotidylexotransferase activity IEA--
    GO:0016779nucleotidyltransferase activity ----
         
    DNTT for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dntt):
     hematopoietic system  immune system  normal 

    DNTT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DNTT: Dntttm1Fwa Dntttm1Gfn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNTT
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TDT_HUMAN, P04053: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular3
    mitochondrion3
    cytoskeleton2
    endoplasmic reticulum2
    plasma membrane2
    vacuole2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    DNTT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DNTT About    
    See pathways by source

    SuperPathContained pathways About
    1Non-homologous end-joining
    Non-homologous end-joining0.37
    2Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    3Hematopoietic cell lineage
    Hematopoietic cell lineage

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DNTT
        Validated targets of C-MYC transcriptional repression


    2 Kegg Pathways  (Kegg details for DNTT):
        Non-homologous end-joining
    Hematopoietic cell lineage


    DNTT for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DNTT: 
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DNTT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNTT (P040533 ENSP000003602164) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNTTIP2Q5QJE63, ENSP000003521374I2D: score=2 STRING: ENSP00000352137
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    XRCC6P129563, ENSP000003522574I2D: score=2 STRING: ENSP00000352257
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process ----
    GO:0006304DNA modification IEA--

    DNTT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DNTT
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNTT (TDT)

    3 HMDB Compounds for DNTT    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for DNTT    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2',3'-Dideoxyadenosine-5'-Triphosphate-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for DNTT gene (see all 55)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cd 79 75.2 4 17498589 (1), 18686384 (1), 19665353 (1), 12446447 (1)
    naphthol as-d chloroacetate 71 1 14692536 (1)
    paraffin 46.4 15 9343323 (5), 9227346 (2), 10233410 (1), 16454553 (1) (see all 9)
    sanguinarine 44.2 2 11770015 (1)
    dutp 43.8 10 10193519 (1), 15911970 (1), 18309685 (1), 19059832 (1) (see all 8)
    parathion 42.6 4 2162699 (3), 16212545 (1)
    fitc 41.5 9 9845437 (2), 7924695 (1), 16113043 (1), 7895530 (1) (see all 6)
    eb 1089 40.6 3 8903423 (1), 9846632 (1)
    bzatp 40.6 1 12899380 (1)
    propidium 38.1 1 9060958 (1)



    DNTT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DNTT gene (2 alternative transcripts): 
    NM_001017520.1  NM_004088.3  

    Unigene Cluster for DNTT:

    Deoxynucleotidyltransferase, terminal
    Hs.534206  [show with all ESTs]
    Unigene Representative Sequence: NM_004088
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371174 ENST00000419175(uc001kmf.3 uc001kmg.3)
    miRNA
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    Additional mRNA sequence: 

    AB046378.1 AK130771.1 AK223317.1 AK313615.1 BC012920.1 K01919.1 M26147.1 

    5 DOTS entries:

    DT.75163025  DT.114143  DT.100739794  DT.121216459  DT.100686314 

    21 AceView cDNA sequences:

    BX281386 BP368640 AK130771 CR597750 NM_004088 BG392804 AL559015 BM454641 
    K01919 BX340469 BX348525 BC012920 BP367455 BP367885 AB046378 AL558696 
    BG258914 AW951054 AA306371 M11722 AL580462 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DNTT    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                -                                             


    ECgene alternative splicing isoforms for DNTT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNTT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATGACTG
    DNTT Expression
    About this image


    DNTT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 9 entries
             Pro B-Cells Hematopoietic Bone Marrow
     
     Thymus (Hematopoietic System)    fully expand to see all 4 entries
             Double Negative 3 Thymocytes Thymus
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Lateral Ventricle
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DNTT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNTT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534206
        Pathway & Disease-focused RT2 Profiler PCR Array including DNTT: 
              Lymphoma in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNTT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DNTT gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dntt1 , 5 deoxynucleotidyltransferase, terminal1, 5 80.55(n)1
    80.75(a)1
      19 (34.32 cM)5
    216731  NM_001043228.11  NP_001036693.11 
     410292755 
    chicken
    (Gallus gallus)
    Aves DNTT1 deoxynucleotidyltransferase, terminal 68.6(n)
    64.4(a)
      396351  NM_205389.1  NP_990720.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNTT6
    DNA nucleotidylexotransferase
    62(a)
    1 ↔ 1
    GL343262.1(1035028-1194831)
    African clawed frog
    (Xenopus laevis)
    Amphibia dntt-A2 deoxynucleotidyltransferase, terminal 74.14(n)    U07803.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dntt1 deoxynucleotidyltransferase, terminal 54.5(n)
    48.25(a)
      544653  NM_001014817.1  NP_001014817.1 


    ENSEMBL Gene Tree for DNTT (if available)
    TreeFam Gene Tree for DNTT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DNTT gene
    POLB2  POLM2  POLL2  
    1 SIMAP similar gene for DNTT using alignment to 2 protein entries:     TDT_HUMAN (see all proteins):
    POLM

    DNTT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNTT (see all 885)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154459601,2
    F--98062096(+) GGGCAG/ACCTGA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1456835891,2
    --98062127(+) ACATCC/TCAGTA 2 -- us2k10--------
    rs1411616171,2
    --98062155(+) TTACT-/GCTTAG 2 -- us2k10--------
    rs788318341,2
    --98062201(+) GGAACA/GAACAC 2 -- us2k10--------
    rs741536221,2
    C,F--98062255(+) CTGCAG/ACACCA 2 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1426203721,2
    C--98062436(+) CCCTTC/TTGTTA 2 -- us2k10--------
    rs741536231,2
    C,F--98062486(+) TTTCAT/GGACTT 2 -- us2k12Minor allele frequency- G:0.10WA 120
    rs1178932451,2
    F--98062535(+) TTAGAC/TAGCTG 2 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1446462681,2
    --98062753(+) GGCCAG/TCCATG 2 -- us2k10--------
    rs1512472161,2
    --98062847(+) CAACAC/TGGTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DNTT (98064085 - 98098321 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNTT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831949CNV Gain17160897
    nsv831950CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187410    OMIM disorders: --

    Selected diseases for DNTT (see all 71):    
    About MalaCards
    acute non lymphoblastic leukemia    acute biphenotypic leukemia    primary malignant lymphoma    adenosine deaminase deficiency
    lymphoblastic lymphoma    spiradenoma    follicular dendritic cell tumor    gastrointestinal system disease
    thymic epithelial tumor    merkel cell carcinoma    thymoma    acute leukemia
    thymic carcinoma    childhood leukemia    lupus nephritis    lymphoid leukemia
    lymphoblastic leukemia    toxic encephalopathy    myelodysplastic syndromes    mucoepidermoid carcinoma

    8 diseases from the University of Copenhagen DISEASES database for DNTT:
    Vascular disease     Leukemia     Lymphoma     Brain disease
    Carcinoma     Eye disease     Heart disease     Gastrointestinal system disease

    DNTT for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for DNTT gene (see all 52)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma lymphoblastic 86.2 23 11190795 (2), 18480005 (2), 7937725 (2), 9042293 (2) (see all 16)
    lymphoblastic leukemia acute 77.1 22 9343323 (3), 7723388 (2), 16454553 (2), 16918360 (1) (see all 14)
    acute leukemia 76.2 25 7723388 (3), 1338518 (2), 18426728 (2), 7524307 (1) (see all 17)
    t-all 76.1 19 14961034 (3), 17430665 (2), 1698878 (2), 8152264 (1) (see all 11)
    leukemia 74.8 48 8371592 (2), 8709648 (2), 8366299 (2), 8555067 (2) (see all 39)
    leukaemia lymphocytic 64.9 13 17430665 (2), 8217792 (1), 8709648 (1), 9697877 (1) (see all 9)
    sarcoma granulocytic 63.8 2 7572794 (2)
    blast crisis 62.2 4 7924695 (1), 1996546 (1), 1592097 (1)
    b-all 61.8 3 17430665 (1), 8683996 (1), 17652839 (1)
    minimal residual disease 61.7 6 7723388 (1), 8555067 (1), 9576196 (1), 1836104 (1) (see all 5)

    Genetic Association Database (GAD): DNTT
    Human Genome Epidemiology (HuGE) Navigator: DNTT (1 document)

    Export disorders for DNTT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNTT gene, integrated from 10 sources (see all 372):
    (articles sorted by number of sources associating them with DNTT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase. (PubMed id 8163485)1, 2, 9 Yang B.... Coleman M.S. (J. Biol. Chem. 1994)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone. (PubMed id 12786946)1, 2 Fujita K.... Koiwai O. (Genes Cells 2003)
    5. Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. (PubMed id 12960389)1, 2 Mahajan K.N. and Mitchell B.S. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65. (PubMed id 11473582)1, 2 Yamashita N.... Koiwai O. (Genes Cells 2001)
    7. Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen. (PubMed id 11554927)1, 2 Ibe S....Koiwai O. (Genes Cells 2001)
    8. Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene. (PubMed id 3395350)1, 2 Koiwai O. and Morita A. (Biochem. Biophys. Res. Commun. 1988)
    9. Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region. (PubMed id 2833741)1, 2 Riley L.K.... Coleman M.S. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    10. Expression of human terminal deoxynucleotidyl transferase in Escherichia coli. (PubMed id 2863268)1, 2 Peterson R.C....Bollum F.J. (J. Biol. Chem. 1985)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1791 HGNC: 2983 AceView: DNTT Ensembl:ENSG00000107447 euGenes: HUgn1791
    ECgene: DNTT Kegg: 1791 H-InvDB: DNTT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNTT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DNTT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DNTT gene:
    Search GeneIP for patents involving DNTT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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