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Aliases for DNPH1 Gene

Aliases for DNPH1 Gene

  • 2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1 2
  • 2-Deoxynucleoside 5-Phosphate N-Hydrolase 1 2 3
  • C6orf108 3 4
  • RCL 3 4
  • Deoxyribonucleoside 5-Monophosphate N-Glycosidase 3
  • Chromosome 6 Open Reading Frame 108 2
  • C-Myc-Responsive Protein Rcl 3
  • C-Myc-Responsive Protein RCL 4
  • Putative C-Myc-Responsive 3
  • DJ330M21.3 3
  • EC 3.2.2.- 4

External Ids for DNPH1 Gene

Previous HGNC Symbols for DNPH1 Gene

  • C6orf108

Summaries for DNPH1 Gene

Entrez Gene Summary for DNPH1 Gene

  • This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNPH1 Gene

DNPH1 (2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1) is a Protein Coding gene. GO annotations related to this gene include nucleoside deoxyribosyltransferase activity and deoxyribonucleoside 5-monophosphate N-glycosidase activity.

UniProtKB/Swiss-Prot for DNPH1 Gene

  • Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5-monophosphates containing purine bases are preferred to those containing pyrimidine bases.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNPH1 Gene

Genomics for DNPH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNPH1 Gene

Start:
43,225,629 bp from pter
End:
43,229,484 bp from pter
Size:
3,856 bases
Orientation:
Minus strand

Genomic View for DNPH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNPH1 Gene

No data available for Regulatory Elements for DNPH1 Gene

Proteins for DNPH1 Gene

  • Protein details for DNPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43598-DNPH1_HUMAN
    Recommended name:
    2-deoxynucleoside 5-phosphate N-hydrolase 1
    Protein Accession:
    O43598
    Secondary Accessions:
    • B2LUJ9

    Protein attributes for DNPH1 Gene

    Size:
    174 amino acids
    Molecular mass:
    19108 Da
    Quaternary structure:
    • Monomer and homodimer.

    Three dimensional structures from OCA and Proteopedia for DNPH1 Gene

    Alternative splice isoforms for DNPH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DNPH1 Gene

Proteomics data for DNPH1 Gene at MOPED

Post-translational modifications for DNPH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DNPH1 Gene

Antibody Products

No data available for DME Specific Peptides for DNPH1 Gene

Domains for DNPH1 Gene

Protein Domains for DNPH1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43598

UniProtKB/Swiss-Prot:

DNPH1_HUMAN :
  • O43598
Family:
  • Belongs to the 2-deoxynucleoside 5-phosphate N-hydrolase 1 family.
genes like me logo Genes that share domains with DNPH1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for DNPH1 Gene

Function for DNPH1 Gene

Molecular function for DNPH1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=57 uM for dGMP {ECO:0000269 PubMed:24260472}; KM=97 uM for dAMP {ECO:0000269 PubMed:24260472}; KM=104 uM for dIMP {ECO:0000269 PubMed:24260472}; KM=2500 uM for dCMP {ECO:0000269 PubMed:24260472}; KM=7800 uM for dUMP {ECO:0000269 PubMed:24260472}; KM=25000 uM for dTMP {ECO:0000269 PubMed:24260472}; Note=kcat is 0.002 sec(-1) with dGMP as substrate. kcat is 0.0025 sec(-1) with dAMP as substrate. kcat is 0.0016 sec(-1) with dIMP as substrate. kcat is 0.2 sec(-1) with dUMP as substrate. kcat is 0.0083 sec(-1) with dCMP as substrate. kcat is 0.025 sec(-1) with dTMP as substrate. {ECO:0000269 PubMed:24260472};
UniProtKB/Swiss-Prot CatalyticActivity: A deoxyribonucleoside 5-monophosphate + H(2)0 = deoxyribose 5-monophosphate + a purine or pyrimidine base.
UniProtKB/Swiss-Prot Function: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
UniProtKB/Swiss-Prot Induction: Expression is induced by ETV1.

Enzyme Numbers (IUBMB) for DNPH1 Gene

Gene Ontology (GO) - Molecular Function for DNPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0050144 nucleoside deoxyribosyltransferase activity IEA --
GO:0070694 deoxyribonucleoside 5-monophosphate N-glycosidase activity ISS --
genes like me logo Genes that share ontologies with DNPH1: view

Phenotypes for DNPH1 Gene

GenomeRNAi human phenotypes for DNPH1:
genes like me logo Genes that share phenotypes with DNPH1: view

Animal Model Products

CRISPR Products

miRNA for DNPH1 Gene

miRTarBase miRNAs that target DNPH1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNPH1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DNPH1 Gene

Localization for DNPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNPH1 Gene

Cytoplasm. Nucleus.

Gene Ontology (GO) - Cellular Components for DNPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DNPH1: view

No data available for Subcellular locations from COMPARTMENTS for DNPH1 Gene

Pathways for DNPH1 Gene

SuperPathways for DNPH1 Gene

No Data Available

Interacting Proteins for DNPH1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000230431%0d%0a9606.ENSP00000290650%0d%0a9606.ENSP00000363384%0d%0a9606.ENSP00000262746%0d%0a9606.ENSP00000246069%0d%0a9606.ENSP00000291386%0d%0a
Selected Interacting proteins: O43598-DNPH1_HUMAN ENSP00000230431 for DNPH1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for DNPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation TAS 9271375
GO:0009116 nucleoside metabolic process IEA --
GO:0009117 nucleotide metabolic process IEA --
GO:0009159 deoxyribonucleoside monophosphate catabolic process ISS --
GO:0030307 positive regulation of cell growth ISS --
genes like me logo Genes that share ontologies with DNPH1: view

No data available for Pathways by source for DNPH1 Gene

Transcripts for DNPH1 Gene

mRNA/cDNA for DNPH1 Gene

Unigene Clusters for DNPH1 Gene

2-deoxynucleoside 5-phosphate N-hydrolase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNPH1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNPH1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: -

Relevant External Links for DNPH1 Gene

GeneLoc Exon Structure for
DNPH1
ECgene alternative splicing isoforms for
DNPH1

Expression for DNPH1 Gene

mRNA expression in normal human tissues for DNPH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNPH1 Gene

SOURCE GeneReport for Unigene cluster for DNPH1 Gene Hs.109752

mRNA Expression by UniProt/SwissProt for DNPH1 Gene

O43598-DNPH1_HUMAN
Tissue specificity: Expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, and thymus. Expressed at high levels in heart, kidney, liver, skeletal muscle and spleen. Overexpressed in a significant proportion of breast cancers.
genes like me logo Genes that share expressions with DNPH1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DNPH1 Gene

Orthologs for DNPH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DNPH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf108 35
  • 100 (n)
  • 100 (a)
C6ORF108 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C23H6orf108 35
  • 84.08 (n)
  • 85.35 (a)
DNPH1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C12H6orf108 35
  • 87.61 (n)
  • 88.51 (a)
DNPH1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnph1 35
  • 80.48 (n)
  • 78.95 (a)
Dnph1 16
Dnph1 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DNPH1 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnph1 35
  • 79.96 (n)
  • 79.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29697 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10127 35
zebrafish
(Danio rerio)
Actinopterygii dnph1 35
  • 63.99 (n)
  • 64.23 (a)
dnph1 36
  • 62 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6455 36
  • 45 (a)
OneToOne
Species with no ortholog for DNPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DNPH1 Gene

ENSEMBL:
Gene Tree for DNPH1 (if available)
TreeFam:
Gene Tree for DNPH1 (if available)

Paralogs for DNPH1 Gene

Pseudogenes.org Pseudogenes for DNPH1 Gene

genes like me logo Genes that share paralogs with DNPH1: view

No data available for Paralogs for DNPH1 Gene

Variants for DNPH1 Gene

Sequence variations from dbSNP and Humsavar for DNPH1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs7832 -- 43,226,139(-) GTGGT(C/T)GTGGC reference, synonymous-codon
rs1802183 -- 43,226,360(-) TCCAT(G/T)AGCAG reference, stop-gained
rs2233820 -- 43,230,037(-) gtgac(A/G)cctag upstream-variant-2KB
rs2233821 -- 43,229,764(-) CGAGG(G/T)TCTTG upstream-variant-2KB
rs2233822 -- 43,229,741(-) TGGGA(A/G)GATGC upstream-variant-2KB

Relevant External Links for DNPH1 Gene

HapMap Linkage Disequilibrium report
DNPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DNPH1 Gene

Disorders for DNPH1 Gene

No disorders were found for DNPH1 Gene.

No data available for UniProtKB/Swiss-Prot for DNPH1 Gene

Publications for DNPH1 Gene

  1. Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. (PMID: 9271375) Lewis B.C. … Dang C.V. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. The c-Myc target gene Rcl (C6orf108) encodes a novel enzyme, deoxynucleoside 5'-monophosphate N-glycosidase. (PMID: 17234634) Ghiorghi Y.K. … Kaminski P.A. (J. Biol. Chem. 2007) 2 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DNPH1 Gene

Sources for DNPH1 Gene

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