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Aliases for DNPEP Gene

Aliases for DNPEP Gene

  • Aspartyl Aminopeptidase 2 3
  • EC 3.4.11.21 4 63
  • ASPEP 3 4
  • DAP 3 4

External Ids for DNPEP Gene

Previous GeneCards Identifiers for DNPEP Gene

  • GC02M218261
  • GC02M218959
  • GC02M220201
  • GC02M220440
  • GC02M220063
  • GC02M219946
  • GC02M220238
  • GC02M212091

Summaries for DNPEP Gene

Entrez Gene Summary for DNPEP Gene

  • The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for DNPEP Gene

DNPEP (Aspartyl Aminopeptidase) is a Protein Coding gene. Among its related pathways are Akt Signaling and PAK Pathway. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity.

UniProtKB/Swiss-Prot for DNPEP Gene

  • Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Gene Wiki entry for DNPEP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNPEP Gene

Genomics for DNPEP Gene

Regulatory Elements for DNPEP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DNPEP Gene

Chromosome:
2
Start:
219,373,458 bp from pter
End:
219,400,022 bp from pter
Size:
26,565 bases
Orientation:
Minus strand

Genomic View for DNPEP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DNPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNPEP Gene

Proteins for DNPEP Gene

  • Protein details for DNPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULA0-DNPEP_HUMAN
    Recommended name:
    Aspartyl aminopeptidase
    Protein Accession:
    Q9ULA0
    Secondary Accessions:
    • Q9BW44
    • Q9NUV5

    Protein attributes for DNPEP Gene

    Size:
    475 amino acids
    Molecular mass:
    52428 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    • Tetrahedron-shaped homododecamer built from six homodimers.
    SequenceCaution:
    • Sequence=BAA92014.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNPEP Gene

neXtProt entry for DNPEP Gene

Proteomics data for DNPEP Gene at MOPED

Post-translational modifications for DNPEP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for DNPEP Gene

Gene Families for DNPEP Gene

Protein Domains for DNPEP Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULA0

UniProtKB/Swiss-Prot:

DNPEP_HUMAN :
  • Belongs to the peptidase M18 family.
Family:
  • Belongs to the peptidase M18 family.
genes like me logo Genes that share domains with DNPEP: view

Function for DNPEP Gene

Molecular function for DNPEP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
UniProtKB/Swiss-Prot EnzymeRegulation:
One of the zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimulates the enzymatic activity.
UniProtKB/Swiss-Prot Function:
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Enzyme Numbers (IUBMB) for DNPEP Gene

Gene Ontology (GO) - Molecular Function for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DNPEP: view

Phenotypes for DNPEP Gene

genes like me logo Genes that share phenotypes with DNPEP: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNPEP

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DNPEP Gene

Localization for DNPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNPEP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DNPEP Gene COMPARTMENTS Subcellular localization image for DNPEP gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
vacuole 1

Gene Ontology (GO) - Cellular Components for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with DNPEP: view

Pathways & Interactions for DNPEP Gene

genes like me logo Genes that share pathways with DNPEP: view

Pathways by source for DNPEP Gene

1 Cell Signaling Technology pathway for DNPEP Gene
1 BioSystems pathway for DNPEP Gene

Gene Ontology (GO) - Biological Process for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process TAS 9632644
genes like me logo Genes that share ontologies with DNPEP: view

No data available for SIGNOR curated interactions for DNPEP Gene

Drugs & Compounds for DNPEP Gene

(1) Drugs for DNPEP Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with DNPEP: view

Transcripts for DNPEP Gene

Unigene Clusters for DNPEP Gene

Aspartyl aminopeptidase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DNPEP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DNPEP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: -
SP8:
SP9:
SP10:
SP11: -

ExUns: 15b ^ 16a · 16b · 16c ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DNPEP Gene

GeneLoc Exon Structure for
DNPEP
ECgene alternative splicing isoforms for
DNPEP

Expression for DNPEP Gene

mRNA expression in normal human tissues for DNPEP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DNPEP Gene



SOURCE GeneReport for Unigene cluster for DNPEP Gene Hs.258551

mRNA Expression by UniProt/SwissProt for DNPEP Gene

Q9ULA0-DNPEP_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DNPEP: view

Protein tissue co-expression partners for DNPEP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for DNPEP Gene

Orthologs for DNPEP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNPEP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DNPEP 35
  • 89.53 (n)
  • 92.14 (a)
DNPEP 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DNPEP 35
  • 89.59 (n)
  • 92.03 (a)
DNPEP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dnpep 35
  • 86.46 (n)
  • 89.89 (a)
Dnpep 16
Dnpep 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DNPEP 35
  • 99.09 (n)
  • 98.53 (a)
DNPEP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dnpep 35
  • 86.53 (n)
  • 90.11 (a)
oppossum
(Monodelphis domestica)
Mammalia DNPEP 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves DNPEP 35
  • 74.8 (n)
  • 78.37 (a)
DNPEP 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DNPEP 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dnpep 35
  • 70.24 (n)
  • 72.53 (a)
Str.2142 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20819 35
zebrafish
(Danio rerio)
Actinopterygii dnpep 35
  • 68.03 (n)
  • 70.54 (a)
zgc55944 35
dnpep 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10876 35
worm
(Caenorhabditis elegans)
Secernentea F01F1.9 37
  • 50 (a)
dnpp-1 35
  • 55.51 (n)
  • 52.11 (a)
dnpp-1 36
  • 49 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21297g 35
  • 51.1 (n)
  • 47.14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APE4 35
  • 49.41 (n)
  • 47.14 (a)
APE4 36
  • 43 (a)
OneToOne
APE4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60160 35
  • 54.24 (n)
  • 52.63 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1803 35
barley
(Hordeum vulgare)
Liliopsida Hv.1571 35
rice
(Oryza sativa)
Liliopsida Os.16710 35
Os12g0236500 35
  • 54.57 (n)
  • 51.84 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7128 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00122 35
  • 57.52 (n)
  • 52.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes aap1 35
  • 49.56 (n)
  • 49.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10534 36
  • 54 (a)
OneToOne
Species with no ortholog for DNPEP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNPEP Gene

ENSEMBL:
Gene Tree for DNPEP (if available)
TreeFam:
Gene Tree for DNPEP (if available)

Paralogs for DNPEP Gene

No data available for Paralogs for DNPEP Gene

Variants for DNPEP Gene

Sequence variations from dbSNP and Humsavar for DNPEP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs878437 -- 219,385,600(-) AGGGC(G/T)GCAGA intron-variant
rs907679 -- 219,385,425(+) TCACC(A/G)CAGGC reference, missense
rs1132736 -- 219,386,078(-) CGGCT(A/G)GAGCA synonymous-codon, reference
rs1235397 -- 219,377,333(+) cttta(A/G)aaatt intron-variant
rs1801950 -- 219,374,866(-) CCCTC(A/T)CCCTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DNPEP Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv483018 CNV Gain 15286789

Variation tolerance for DNPEP Gene

Residual Variation Intolerance Score: 35.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNPEP Gene

HapMap Linkage Disequilibrium report
DNPEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNPEP Gene

Disorders for DNPEP Gene

Relevant External Links for DNPEP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DNPEP
genes like me logo Genes that share disorders with DNPEP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNPEP Gene

Publications for DNPEP Gene

  1. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. (PMID: 9632644) Wilk S. … Magnusson R.P. (J. Biol. Chem. 1998) 2 23 67
  2. Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. (PMID: 16985214) Varona A. … Larrinaga G. (Am. J. Physiol. Renal Physiol. 2007) 23 67
  3. The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum. (PMID: 17720817) Teuscher F. … Trenholme K.R. (J. Biol. Chem. 2007) 23 67
  4. Characterization of Aspergillus oryzae aspartyl aminopeptidase expressed in Escherichia coli. (PMID: 17928682) Watanabe J. … Yamazaki T. (Biosci. Biotechnol. Biochem. 2007) 25 26
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for DNPEP Gene

Sources for DNPEP Gene

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