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DNPEP Gene

protein-coding   GIFtS: 58
GCID: GC02M220238

Aspartyl Aminopeptidase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aspartyl Aminopeptidase1 2
ASPEP2 3 5
DAP2 3 5
EC 3.4.11.213 8

External Ids:    HGNC: 29811   Entrez Gene: 235492   Ensembl: ENSG000001239927   OMIM: 6113675   UniProtKB: Q9ULA03   

Export aliases for DNPEP gene to outside databases

Previous GC identifers: GC02M218261 GC02M218959 GC02M220201 GC02M220440 GC02M220063 GC02M219946 GC02M212091


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DNPEP Gene:
The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors
aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of
intracellular proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for DNPEP Gene:
DNPEP (aspartyl aminopeptidase) is a protein-coding gene. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity.

UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0
Function: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an
important role in intracellular protein and peptide metabolism

Gene Wiki entry for DNPEP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DNPEP gene promoter:
         TBP   ATF-2   FOXO1a   MyoD   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNPEP promoter sequence
   Search Chromatin IP Primers for DNPEP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DNPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q36.1

DNPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNPEP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M220238:  view genomic region     (about GC identifiers)

Start:
220,238,180 bp from pter      End:
220,264,744 bp from pter
Size:
26,565 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0 (See protein sequence)
Recommended Name: Aspartyl aminopeptidase  
Size: 475 amino acids; 52428 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Tetrahedron-shaped homododecamer built from six homodimers
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=BAA92014.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DNPEP:
4DYO (3D)    
Secondary accessions: Q9BW44 Q9NUV5

Explore the universe of human proteins at neXtProt for DNPEP: NX_Q9ULA0

Explore proteomics data for DNPEP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DNPEP (Q9ULA0) (see all 10)
     GAHTDSP  AMHSIRE  SADMAHA  NENFGPN 


    See DNPEP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036232.2  
    ENSEMBL proteins: 
     ENSP00000273075   ENSP00000363083   ENSP00000431076   ENSP00000363074   ENSP00000363077  
     ENSP00000410684   ENSP00000400944   ENSP00000429960   ENSP00000317252   ENSP00000412003  
     ENSP00000414739   ENSP00000429468   ENSP00000428531   ENSP00000430630  

    DNPEP Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DNPEP
    OriGene Protein Over-expression Lysate for DNPEP
    OriGene MassSpec for DNPEP
    OriGene Custom Protein Services for DNPEP
    GenScript Custom Purified and Recombinant Proteins Services for DNPEP
    Novus Biologicals DNPEP Protein
    Novus Biologicals DNPEP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DNPEP 

    DNPEP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DNPEP
    OriGene Custom Antibody Services for DNPEP
    Novus Biologicals DNPEP Antibodies
    Abcam antibodies for DNPEP
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for DNPEP
    LSBio Antibodies in human, mouse, rat for DNPEP

    DNPEP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DNPEP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DNPEP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Aminopeptidase A
    Aminopeptidases

    2 InterPro protein domains:
     IPR023358 Peptidase_M18_dom2
     IPR001948 Peptidase_M18

    Graphical View of Domain Structure for InterPro Entry Q9ULA0

    ProtoNet protein and cluster: Q9ULA0

    1 Blocks protein domain: IPB001948 Aminopeptidase I zinc metalloprotease (M18) signature

    UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0
    Similarity: Belongs to the peptidase M18 family


    Find genes that share domains with DNPEP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNPEP_HUMAN, Q9ULA0
    Function: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an
    important role in intracellular protein and peptide metabolism
    Catalytic activity: Release of an N-terminal aspartate or glutamate from a peptide, with a preference for
    aspartate
    Enzyme regulation: One of the zinc ions is readily exchangeable with other divalent cations such as manganese,
    which strongly stimulates the enzymatic activity (By similarity)

         Enzyme Number (IUBMB): EC 3.4.11.211 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with DNPEP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DNPEP:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DNPEP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DNPEP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNPEP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNPEP

    miRNA
    Products:
        
    miRTarBase miRNAs that target DNPEP:
    hsa-mir-140-5p (MIRT007029)

    Block miRNA regulation of human, mouse, rat DNPEP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNPEP (see all 9):
    hsa-miR-4251 hsa-miR-146a hsa-miR-218-1* hsa-miR-519e* hsa-miR-4267 hsa-miR-515-5p hsa-miR-1207-3p hsa-miR-1264
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DNPEP
    Predesigned siRNA for gene silencing in human, mouse, rat DNPEP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DNPEP

    Clone
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    OriGene clones in human, mouse for DNPEP (see all 11)
    OriGene ORF clones in mouse, rat for DNPEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNPEP (NM_012100)
    Sino Biological Human cDNA Clone for DNPEP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNPEP
    Addgene plasmids for DNPEP 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DNPEP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNPEP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DNPEP_HUMAN, Q9ULA0: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with DNPEP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DNPEP (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DNPEP
    Interactions:

        Search GeneGlobe Interaction Network for DNPEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DNPEP (Q9ULA03 ENSP000002730754) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216733, ENSP000003685724I2D: score=4 STRING: ENSP00000368572
    KRT31Q153233, ENSP000002516454I2D: score=2 STRING: ENSP00000251645
    KRT82Q9NSB43, ENSP000002579744I2D: score=2 STRING: ENSP00000257974
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    NELFCDQ8IXH73, ENSP000003423004I2D: score=1 STRING: ENSP00000342300
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006518peptide metabolic process TAS9632644

    Find genes that share ontologies with DNPEP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DNPEP

    1 HMDB Compound for DNPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--

    1 DrugBank Compound for DNPEP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17928682 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DNPEP gene: 
    NM_012100.2  

    Unigene Cluster for DNPEP:

    Aspartyl aminopeptidase
    Hs.258551  [show with all ESTs]
    Unigene Representative Sequence: NM_012100
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000273075(uc002vle.2 uc002vli.2 uc010zlg.2) ENST00000373972
    ENST00000523282 ENST00000373963 ENST00000373966 ENST00000490371 ENST00000488051
    ENST00000462779 ENST00000488881 ENST00000457935 ENST00000429013 ENST00000521459
    ENST00000460963(uc002vlj.2) ENST00000522421 ENST00000322176 ENST00000434339
    ENST00000430206 ENST00000520694
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DNPEP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DNPEP (see all 9):
    hsa-miR-4251 hsa-miR-146a hsa-miR-218-1* hsa-miR-519e* hsa-miR-4267 hsa-miR-515-5p hsa-miR-1207-3p hsa-miR-1264
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DNPEP
    Predesigned siRNA for gene silencing in human, mouse, rat DNPEP
    Clone
    Products:
         
    OriGene clones in human, mouse for DNPEP (see all 11)
    OriGene ORF clones in mouse, rat for DNPEP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DNPEP (NM_012100)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNPEP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNPEP
    Addgene plasmids for DNPEP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DNPEP
    OriGene qSTAR qPCR primer pairs in human, mouse for DNPEP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNPEP
      QuantiTect SYBR Green Assays in human, mouse, rat DNPEP
      QuantiFast Probe-based Assays in human, mouse, rat DNPEP

    Additional mRNA sequence: 

    AF005050.2 AK001777.1 AK001977.1 AK021871.1 AK023005.1 AK301919.1 AK302809.1 BC000653.2 
    BC003040.1 BC004854.2 

    21 DOTS entries:

    DT.91773214  DT.100880698  DT.100030734  DT.100880705  DT.100880710  DT.100880715  DT.100030732  DT.121010116 
    DT.95160011  DT.100880711  DT.91773222  DT.100880702  DT.100880712  DT.100808515  DT.100843473  DT.100880681 
    DT.121010107  DT.91773216  DT.40271444  DT.86858245  DT.91878637 

    Selected AceView cDNA sequences (see all 445):

    CR603497 CR599387 BM917003 BU161684 BQ073010 BU733421 CA487247 CR620845 
    CR614945 CR607064 BU623923 CF126344 BE732795 CA422964 AW769434 AL514384 
    CA391092 AL524837 NM_012100 CR602255 BQ029776 BQ646395 BX339529 BM423640 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DNPEP (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:              -     -     -     -           -                                   -     -                 -     -                       -     -           -   
    SP2:                                -                                               -     -                 -     -                       -     -           -   
    SP3:                                -           -                                   -     -                                                                     
    SP4:                                                                                -     -                                                                     
    SP5:                                                                                -     -     -     -     -     -                       -     -           -   

    ExUns: 15b ^ 16a · 16b · 16c ^ 17a · 17b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DNPEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DNPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCTATCC
    DNPEP Expression
    About this image


    DNPEP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    DNPEP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DNPEP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.258551

    UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for DNPEP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DNPEP
    QuantiTect SYBR Green Assays in human, mouse, rat DNPEP
    QuantiFast Probe-based Assays in human, mouse, rat DNPEP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNPEP gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnpep1 , 5 aspartyl aminopeptidase1, 5 86.46(n)1
    89.89(a)1
      1 (38.71 cM)5
    134371  NM_001110831.11  NP_001104301.11 
     753085655 
    chicken
    (Gallus gallus)
    Aves DNPEP1 aspartyl aminopeptidase 74.8(n)
    78.37(a)
      424200  NM_001012919.2  NP_001012937.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNPEP6
    aspartyl aminopeptidase
    61(a)
    1 ↔ 1
    1(95455385-95490080)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208192 Xenopus laevis transcribed sequence with moderate similarity more 81.29(n)    BQ884373.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559442 hypothetical protein MGC55944 73.41(n)   393122  BC044551.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F01F1.93
    dnpp-11
    dnpp-11 50(a)3
    55.51(n)1
    52.11(a)1
      III(5933767-5935322)3
    1758221  NM_065864.51  NP_498265.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APE4(YHR113W)4
    APE41
    Cytoplasmic aspartyl aminopeptidase that may also function more4
    APE41
    49.41(n)1
    47.14(a)1
      8(336337-337809)4
    8565131, 4  NP_011981.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G601601 AT5G60160 54.24(n)
    52.63(a)
      836138  NM_125409.4  NP_200824.1 
    rice
    (Oryza sativa)
    Liliopsida Os.167102 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.53(n)    AK071207.1 


    ENSEMBL Gene Tree for DNPEP (if available)
    TreeFam Gene Tree for DNPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DNPEP (see all 411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447367851,2
    C--220237715(+) AAAGAC/TTGGAA 1 -- ds50010--------
    rs1132777661,2
    F--220237784(+) TTTGAC/ATTTTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs113389071,2
    C--220237926(+) GCTGA-/GATTAC 1 -- ds50012Minor allele frequency- G:0.00NA CSA 4
    rs75871601,2
    C,A--220237972(+) tttagT/Caggga 1 -- ds50015Minor allele frequency- C:0.11NA WA CSA 9
    rs1493173481,2
    --220238017(+) ACTCCC/TGACCT 1 -- ds50010--------
    rs1916889311,2
    C--220238032(+) TGATCC/TGCCCA 1 -- ds50010--------
    rs1848993851,2
    --220238136(+) GAGTGC/TGGTGG 1 -- ds50010--------
    rs1893813281,2
    C--220238225(+) TACAGA/GTGTGT 1 -- ut310--------
    rs124651341,2
    C,F,H--220238256(+) tttttG/Atattt 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs1810272381,2
    --220238355(+) ATGCTA/GGGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DNPEP (220238180 - 220264744 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNPEP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834543CNV Loss17160897
    nsv483018CNV Gain15286789

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DNPEP
    DNA2.0 Custom Variant and Variant Library Synthesis for DNPEP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611367    OMIM disorders: --


    Find genes that share disorders with DNPEP           About GenesLikeMe


    Export disorders for DNPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DNPEP gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DNPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. (PubMed id 9632644)1, 2, 3, 9 Wilk S.... Magnusson R.P. (J. Biol. Chem. 1998)
    2. Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. (PubMed id 22720794)1, 2 Chaikuad A.... Yue W.W. (BMC Struct. Biol. 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase. (PubMed id 12413488)1, 9 Wilk S....Magnusson R.P. (Arch. Biochem. Biophys. 2002)
    6. A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. (PubMed id 23740937)1 Martin J.E....Martin J. (Hum. Mol. Genet. 2013)
    7. Clinical impact of aspartyl aminopeptidase expression and activity in colorectal cancer. (PubMed id 23948443)1 Larrinaga G....LA^pez J.I. (Transl Res 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23549 HGNC: 2981 AceView: DNPEP Ensembl:ENSG00000123992 euGenes: HUgn23549
    ECgene: DNPEP H-InvDB: DNPEP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DNPEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DNPEP gene:
    Search GeneIP for patents involving DNPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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