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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNPEP Gene

protein-coding   GIFtS: 58
GCID: GC02M220238

Aspartyl Aminopeptidase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aspartyl Aminopeptidase1 2
ASPEP2 3
DAP2 3
EC 3.4.11.213 8

External Ids:    HGNC: 29811   Entrez Gene: 235492   Ensembl: ENSG000001239927   OMIM: 6113675   UniProtKB: Q9ULA03   

Export aliases for DNPEP gene to outside databases

Previous GC identifers: GC02M218261 GC02M218959 GC02M220201 GC02M220440 GC02M220063 GC02M219946 GC02M212091


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNPEP Gene:
The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors
aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of
intracellular proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for DNPEP Gene: 
DNPEP (aspartyl aminopeptidase) is a protein-coding gene. Diseases associated with DNPEP include renovascular hypertension, and clear cell renal cell carcinoma. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity.

UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0
Function: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an
important role in intracellular protein and peptide metabolism

Gene Wiki entry for DNPEP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNPEP gene promoter:
         TBP   ATF-2   FOXO1a   MyoD   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDNPEP promoter sequence
   Search SABiosciences Chromatin IP Primers for DNPEP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNPEP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q36.1

DNPEP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNPEP gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M220238:  view genomic region     (about GC identifiers)

Start:
220,238,180 bp from pter      End:
220,264,744 bp from pter
Size:
26,565 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0 (See protein sequence)
Recommended Name: Aspartyl aminopeptidase  
Size: 475 amino acids; 52428 Da
Cofactor: Binds 2 zinc ions per subunit
Subunit: Tetrahedron-shaped homododecamer built from six homodimers
Subcellular location: Cytoplasm
Caution: It is uncertain whether Met-1 or Met-5 is the initiator
Sequence caution: Sequence=BAA92014.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DNPEP:
4DYO (3D)    
Secondary accessions: Q9BW44 Q9NUV5

Explore the universe of human proteins at neXtProt for DNPEP: NX_Q9ULA0

Explore proteomics data for DNPEP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULA0

  • 4/10 DME Specific Peptides for DNPEP (Q9ULA0) (see all 10)
     GAHTDSP  AMHSIRE  SADMAHA  NENFGPN 

    DNPEP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DNPEP Protein Expression
    REFSEQ proteins: NP_036232.2  
    ENSEMBL proteins: 
     ENSP00000273075   ENSP00000363083   ENSP00000431076   ENSP00000363074   ENSP00000363077  
     ENSP00000410684   ENSP00000400944   ENSP00000429960   ENSP00000317252   ENSP00000412003  
     ENSP00000414739   ENSP00000429468   ENSP00000428531   ENSP00000430630  

    Human Recombinant Protein Products for DNPEP: 
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    Novus Biologicals DNPEP Protein
    Novus Biologicals DNPEP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    DNPEP for ontologies           About GeneDecksing



    DNPEP Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Aminopeptidase A 
    Aminopeptidases

    2 InterPro protein domains:
     IPR023358 Peptidase_M18_dom2
     IPR001948 Peptidase_M18

    Graphical View of Domain Structure for InterPro Entry Q9ULA0

    ProtoNet protein and cluster: Q9ULA0

    1 Blocks protein domain: IPB001948 Aminopeptidase I zinc metalloprotease (M18) signature

    UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0
    Similarity: Belongs to the peptidase M18 family


    DNPEP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DNPEP_HUMAN, Q9ULA0
    Function: Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an
    important role in intracellular protein and peptide metabolism
    Catalytic activity: Release of an N-terminal aspartate or glutamate from a peptide, with a preference for
    aspartate
    Enzyme regulation: One of the zinc ions is readily exchangeable with other divalent cations such as manganese,
    which strongly stimulates the enzymatic activity (By similarity)

         Enzyme Number (IUBMB): EC 3.4.11.211 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004177aminopeptidase activity IEA--
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    DNPEP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DNPEP:
     Synthetic lethal with Ras 

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DNPEP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DNPEP 

    miRNA
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    miRTarBase miRNAs that target DNPEP:
    hsa-mir-183 (MIRT005726)

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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DNPEP (see all 9):
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNPEP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DNPEP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/34 Interacting proteins for DNPEP (Q9ULA03 ENSP000002730754) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216733, ENSP000003685724I2D: score=4 STRING: ENSP00000368572
    KRT31Q153233, ENSP000002516454I2D: score=2 STRING: ENSP00000251645
    KRT82Q9NSB43, ENSP000002579744I2D: score=2 STRING: ENSP00000257974
    NTMT1Q9BV863, ENSP000003615584I2D: score=2 STRING: ENSP00000361558
    AGTP010193, ENSP000003556274I2D: score=1 STRING: ENSP00000355627
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006518peptide metabolic process TAS9632644

    DNPEP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DNPEP

    1 HMDB Compound for DNPEP    About this table
    CompoundSynonyms CAS #PubMed Ids
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--

    1 DrugBank Compound for DNPEP    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Glutamic Acid(2S)-2-Aminopentanedioic acid (see all 15)56-86-0target--17139284 17928682 17016423

    Search CenterWatch for drugs/clinical trials and news about DNPEP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DNPEP gene: 
    NM_012100.2  

    Unigene Cluster for DNPEP:

    Aspartyl aminopeptidase
    Hs.258551  [show with all ESTs]
    Unigene Representative Sequence: NM_012100
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000273075(uc002vle.2 uc002vli.2 uc010zlg.2) ENST00000373972
    ENST00000523282 ENST00000373963 ENST00000373966 ENST00000490371 ENST00000488051
    ENST00000462779 ENST00000488881 ENST00000457935 ENST00000429013 ENST00000521459
    ENST00000460963(uc002vlj.2) ENST00000522421 ENST00000322176 ENST00000434339
    ENST00000430206 ENST00000520694
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DNPEP (see all 9):
    hsa-miR-4251 hsa-miR-146a hsa-miR-218-1* hsa-miR-519e* hsa-miR-4267 hsa-miR-515-5p hsa-miR-1207-3p hsa-miR-1264
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNPEP
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNPEP
    Sirion Biotech Customized lentivirus for stable overexpression of DNPEP 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNPEP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNPEP

    Additional mRNA sequence: 

    AF005050.2 AK001777.1 AK001977.1 AK021871.1 AK023005.1 AK301919.1 AK302809.1 BC000653.2 
    BC003040.1 BC004854.2 

    21 DOTS entries:

    DT.91773214  DT.100880698  DT.100030734  DT.100880705  DT.100880710  DT.100880715  DT.100030732  DT.121010116 
    DT.95160011  DT.100880711  DT.91773222  DT.100880702  DT.100880712  DT.100808515  DT.100843473  DT.100880681 
    DT.121010107  DT.91773216  DT.40271444  DT.86858245  DT.91878637 

    24/445 AceView cDNA sequences (see all 445):

    CA445437 CR616703 BU521296 AL516777 BQ427473 BU162343 BQ073010 BM917003 
    BM974153 BX401446 BI821651 CD723564 BC000653 CR608875 CB528378 NM_012100 
    BI753578 BQ646395 CR605526 CA417728 CR623295 BQ230792 CA448742 BE409425 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DNPEP (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:              -     -     -     -           -                                   -     -                 -     -                       -     -           -   
    SP2:                                -                                               -     -                 -     -                       -     -           -   
    SP3:                                -           -                                   -     -                                                                     
    SP4:                                                                                -     -                                                                     
    SP5:                                                                                -     -     -     -     -     -                       -     -           -   

    ExUns: 15b ^ 16a · 16b · 16c ^ 17a · 17b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DNPEP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNPEP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCTATCC
    DNPEP Expression
    About this image


    See DNPEP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNPEP

    SOURCE GeneReport for Unigene cluster: Hs.258551

    UniProtKB/Swiss-Prot: DNPEP_HUMAN, Q9ULA0
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for DNPEP
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNPEP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DNPEP gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dnpep1 , 5 aspartyl aminopeptidase1, 5 86.46(n)1
    89.89(a)1
      1 (38.71 cM)5
    134371  NM_001110831.11  NP_001104301.11 
     753085655 
    chicken
    (Gallus gallus)
    Aves DNPEP1 aspartyl aminopeptidase 74.8(n)
    78.37(a)
      424200  NM_001012919.1  NP_001012937.1 
    lizard
    (Anolis carolinensis)
    Reptilia DNPEP6
    Uncharacterized protein
    61(a)
    1 ↔ 1
    1(95455385-95490080)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208192 Xenopus laevis transcribed sequence with moderate similarity more 81.29(n)    BQ884373.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559442 hypothetical protein MGC55944 73.41(n)   393122  BC044551.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F01F1.93
    dnpp-11
    Protein DNPP-11 50(a)3
    55.51(n)1
    52.11(a)1
      III(5933767-5935322)3
    1758221  NM_065864.41  NP_498265.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes APE4(YHR113W)4
    APE41
    Cytoplasmic aspartyl aminopeptidase that may also function more4
    Ape4p1
    49.41(n)1
    47.14(a)1
      8(336337-337809)4
    8565131, 4  NP_011981.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G601601 aspartyl aminopeptidase 54.24(n)
    52.63(a)
      836138  NM_125409.4  NP_200824.1 
    rice
    (Oryza sativa)
    Liliopsida Os.167102 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.53(n)    AK071207.1 


    ENSEMBL Gene Tree for DNPEP (if available)
    TreeFam Gene Tree for DNPEP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/411 SNPs in DNPEP are shown (see all 411)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447367851,2
    C--220237715(+) AAAGAC/TTGGAA 1 -- ds50010--------
    rs1132777661,2
    F--220237784(+) TTTGAC/ATTTTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs113389071,2
    C--220237926(+) GCTGA-/GATTAC 1 -- ds50012Minor allele frequency- G:0.00NA CSA 4
    rs75871601,2
    C,A--220237972(+) tttagT/Caggga 1 -- ds50015Minor allele frequency- C:0.11NA WA CSA 9
    rs1493173481,2
    --220238017(+) ACTCCC/TGACCT 1 -- ds50010--------
    rs1916889311,2
    C--220238032(+) TGATCC/TGCCCA 1 -- ds50010--------
    rs1848993851,2
    --220238136(+) GAGTGC/TGGTGG 1 -- ds50010--------
    rs1893813281,2
    C--220238225(+) TACAGA/GTGTGT 1 -- ut310--------
    rs124651341,2
    C,F,H--220238256(+) tttttG/Atattt 1 -- ut311Minor allele frequency- A:0.06WA 118
    rs1810272381,2
    --220238355(+) ATGCTA/GGGAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DNPEP (220238180 - 220264744 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DNPEP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834543CNV Loss17160897
    nsv483018CNV Gain15286789

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611367    OMIM disorders: --

    7 diseases for DNPEP:    About MalaCards
    renovascular hypertension    clear cell renal cell carcinoma    renal cell carcinoma    tonsillitis
    malaria    hypertension    tuberculosis


    DNPEP for disorders           About GeneDecksing


    Export disorders for DNPEP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNPEP gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with DNPEP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. (PubMed id 9632644)1, 2, 3, 9 Wilk S.... Magnusson R.P. (1998)
    2. Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. (PubMed id 22720794)1, 2 Chaikuad A.... Yue W.W. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase. (PubMed id 12413488)1, 9 Wilk S....Magnusson R.P. (2002)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23549 HGNC: 2981 AceView: DNPEP Ensembl:ENSG00000123992 euGenes: HUgn23549
    ECgene: DNPEP H-InvDB: DNPEP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNPEP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DNPEP gene:
    Search GeneIP for patents involving DNPEP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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