Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DNPEP Gene

Aliases for DNPEP Gene

  • Aspartyl Aminopeptidase 2 3 5
  • EC 4 61
  • ASPEP 3 4
  • DAP 3 4

External Ids for DNPEP Gene

Previous GeneCards Identifiers for DNPEP Gene

  • GC02M218261
  • GC02M218959
  • GC02M220201
  • GC02M220440
  • GC02M220063
  • GC02M219946
  • GC02M220238
  • GC02M212091

Summaries for DNPEP Gene

Entrez Gene Summary for DNPEP Gene

  • The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

GeneCards Summary for DNPEP Gene

DNPEP (Aspartyl Aminopeptidase) is a Protein Coding gene. GO annotations related to this gene include metallopeptidase activity and aminopeptidase activity.

UniProtKB/Swiss-Prot for DNPEP Gene

  • Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Gene Wiki entry for DNPEP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DNPEP Gene

Genomics for DNPEP Gene

Regulatory Elements for DNPEP Gene

Enhancers for DNPEP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G219397 1.4 Ensembl ENCODE dbSUPER 11.4 +1.0 995 3.7 PKNOX1 ATF1 FOXA2 FEZF1 YY1 FOS ZNF263 ZHX2 ZNF592 ZNF579 ASIC4 ENSG00000227432 DNPEP SPEG GMPPA CHPF TMEM198 OBSL1 GLB1L LOC105373884
GH02G219386 1.1 ENCODE 12.5 +12.1 12063 3.4 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3 SP5 ZHX2 DNPEP DES USP37 GLB1L LOC105373884 LOC105373883
GH02G219683 1.2 ENCODE dbSUPER 11.2 -287.7 -287654 7.4 PKNOX1 ATF1 ARID4B SIN3A ZNF143 ZNF263 SP3 CAVIN1 GTF2B NFYC OBSL1 CHPF TMEM198 ENSG00000228973 SLC4A3 DNPEP DNAJB2 ATG9A LOC105373886 RPL23P4
GH02G219401 1.2 Ensembl ENCODE dbSUPER 10.5 -2.6 -2598 1.6 CTCF MXI1 SIN3A ARID4B RAD21 TEAD3 ZNF143 SMC3 EZH2 ZNF654 ASIC4 ENSG00000227432 SPEG GMPPA DNPEP DES
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DNPEP on UCSC Golden Path with GeneCards custom track

Genomic Location for DNPEP Gene

219,373,458 bp from pter
219,400,022 bp from pter
26,565 bases
Minus strand

Genomic View for DNPEP Gene

Genes around DNPEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DNPEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DNPEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DNPEP Gene

Proteins for DNPEP Gene

  • Protein details for DNPEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Aspartyl aminopeptidase
    Protein Accession:
    Secondary Accessions:
    • Q9BW44
    • Q9NUV5

    Protein attributes for DNPEP Gene

    475 amino acids
    Molecular mass:
    52428 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Tetrahedron-shaped homododecamer built from six homodimers.
    • Sequence=BAA92014.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DNPEP Gene

neXtProt entry for DNPEP Gene

Selected DME Specific Peptides for DNPEP Gene


Post-translational modifications for DNPEP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DNPEP Gene

Gene Families for DNPEP Gene

Protein Domains for DNPEP Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M18 family.
  • Belongs to the peptidase M18 family.
genes like me logo Genes that share domains with DNPEP: view

Function for DNPEP Gene

Molecular function for DNPEP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.
UniProtKB/Swiss-Prot EnzymeRegulation:
One of the zinc ions is readily exchangeable with other divalent cations such as manganese, which strongly stimulates the enzymatic activity.
UniProtKB/Swiss-Prot Function:
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.

Enzyme Numbers (IUBMB) for DNPEP Gene

Gene Ontology (GO) - Molecular Function for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004177 aminopeptidase activity TAS 9632644
GO:0005515 protein binding IPI 25416956
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DNPEP: view
genes like me logo Genes that share phenotypes with DNPEP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DNPEP

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DNPEP

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DNPEP Gene

Localization for DNPEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DNPEP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DNPEP gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IBA,TAS --
GO:0005829 cytosol IDA --
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with DNPEP: view

Pathways & Interactions for DNPEP Gene

SuperPathways for DNPEP Gene

No Data Available

Gene Ontology (GO) - Biological Process for DNPEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process TAS 9632644
genes like me logo Genes that share ontologies with DNPEP: view

No data available for Pathways by source and SIGNOR curated interactions for DNPEP Gene

Drugs & Compounds for DNPEP Gene

(1) Drugs for DNPEP Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0
genes like me logo Genes that share compounds with DNPEP: view

Transcripts for DNPEP Gene

Unigene Clusters for DNPEP Gene

Aspartyl aminopeptidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DNPEP

Alternative Splicing Database (ASD) splice patterns (SP) for DNPEP Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - -
SP7: -
SP11: -

ExUns: 15b ^ 16a · 16b · 16c ^ 17a · 17b

Relevant External Links for DNPEP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DNPEP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DNPEP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DNPEP Gene

Protein tissue co-expression partners for DNPEP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DNPEP Gene:


SOURCE GeneReport for Unigene cluster for DNPEP Gene:


mRNA Expression by UniProt/SwissProt for DNPEP Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DNPEP Gene

  • Liver(4.5)
  • Eye(4.2)
  • Nervous system(3.8)
  • Intestine(2.9)
  • Kidney(2.9)
  • Adrenal gland(2.6)
  • Thyroid gland(2.6)
  • Gall bladder(2.3)
  • Lung(2.3)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with DNPEP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DNPEP Gene

Orthologs for DNPEP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DNPEP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DNPEP 34 35
  • 99.09 (n)
(Canis familiaris)
Mammalia DNPEP 34 35
  • 89.59 (n)
(Bos Taurus)
Mammalia DNPEP 34 35
  • 89.53 (n)
(Rattus norvegicus)
Mammalia Dnpep 34
  • 86.53 (n)
(Mus musculus)
Mammalia Dnpep 34 16 35
  • 86.46 (n)
(Monodelphis domestica)
Mammalia DNPEP 35
  • 75 (a)
(Gallus gallus)
Aves DNPEP 34 35
  • 74.8 (n)
(Anolis carolinensis)
Reptilia DNPEP 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnpep 34
  • 70.24 (n)
Str.2142 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20819 34
(Danio rerio)
Actinopterygii dnpep 34 35
  • 68.03 (n)
zgc55944 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10876 34
(Caenorhabditis elegans)
Secernentea dnpp-1 34 35
  • 55.51 (n)
F01F1.9 36
  • 50 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E21297g 34
  • 51.1 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APE4 34 35 37
  • 49.41 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G60160 34
  • 54.24 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1803 34
(Oryza sativa)
Liliopsida Os12g0236500 34
  • 54.57 (n)
Os.16710 34
(Hordeum vulgare)
Liliopsida Hv.1571 34
(Triticum aestivum)
Liliopsida Ta.7128 34
bread mold
(Neurospora crassa)
Ascomycetes NCU00122 34
  • 57.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10534 35
  • 54 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes aap1 34
  • 49.56 (n)
Species where no ortholog for DNPEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DNPEP Gene

Gene Tree for DNPEP (if available)
Gene Tree for DNPEP (if available)

Paralogs for DNPEP Gene

No data available for Paralogs for DNPEP Gene

Variants for DNPEP Gene

Sequence variations from dbSNP and Humsavar for DNPEP Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000186868 -- 219,400,070(+) GCAAT(G/T)TGAAG intron-variant, upstream-variant-2KB
rs1000288318 -- 219,399,979(+) GTGTG(C/G)CTTTT intron-variant, utr-variant-5-prime
rs1000337377 -- 219,393,679(+) CTTTC(C/T)TGGAG intron-variant
rs1000361531 -- 219,399,703(+) AAGCC(A/G)CTTGC intron-variant
rs1000384700 -- 219,400,333(+) GAGCT(C/T)CAGGA intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DNPEP Gene

Variant ID Type Subtype PubMed ID
nsv1126577 CNV deletion 24896259
nsv834543 CNV loss 17160897

Variation tolerance for DNPEP Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DNPEP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DNPEP Gene

Disorders for DNPEP Gene

Relevant External Links for DNPEP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DNPEP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DNPEP Gene

Publications for DNPEP Gene

  1. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. (PMID: 9632644) Wilk S. … Magnusson R.P. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. (PMID: 22720794) Chaikuad A. … Yue W.W. (BMC Struct. Biol. 2012) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase. (PMID: 12413488) Wilk S. … Magnusson R.P. (Arch. Biochem. Biophys. 2002) 3 22 64

Products for DNPEP Gene

  • Addgene plasmids for DNPEP

Sources for DNPEP Gene

Loading form....