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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DNMT3L Gene

protein-coding   GIFtS: 59
GCID: GC21M045666

DNA (cytosine-5-)-methyltransferase 3-like
 Explore 10 diseases affiliated with
DNMT3L via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DNMT3L    

Aliases
for DNMT3L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
DNA (Cytosine-5-)-Methyltransferase 3-Like1 2
Human Cytosine-5-Methyltransferase 3-Like Protein2 11
MGC10901
Cytosine-5-Methyltransferase 3-Like Protein2
DNA (Cytosine-5)-Methyltransferase 3-Like2

External Ids:    HGNC: 29801   Entrez Gene: 299472   Ensembl: ENSG000001421827   OMIM: 6065885   UniProtKB: Q9UJW33   

Export aliases for DNMT3L gene to outside databases

Previous GC identifers: GC21M042176 GC21M042259 GC21M044522 GC21M044490 GC21M031037


Summaries
for DNMT3L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DNMT3L:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome
inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene
encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA
methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it
does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the
establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction
with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: DNM3L_HUMAN, Q9UJW3
Function: Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of
DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA
and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases.
Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of
DNMT3

Gene Wiki entry for DNMT3L


Genomic Views
for DNMT3L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DNMT3L gene promoter:
         c-Fos   AP-1   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNMT3L promoter sequence

   Search SABiosciences Chromatin IP Primers for DNMT3L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNMT3L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
DNMT3L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNMT3L gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M045666:   GeneLoc Nature:405,311-319
Start:
 45,666,222 bp from pter       31,175,615 bp from centromere
End:
 45,682,099 bp from pter 31,191,491 bp from centromere
Size:
 15,878 bases 15,877 bases
Orientation:
 minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF194032
genomic clones: KUD28B11 KUD4G11


Proteins
for DNMT3L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DNM3L_HUMAN, Q9UJW3 (See protein sequence)
Recommended Name: DNA (cytosine-5)-methyltransferase 3-like  
Size: 386 amino acids; 43583 Da
Subunit: Homodimer. Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L).
Interacts with histone H3 (via N-terminus)
Subcellular location: Nucleus (Probable)
Miscellaneous: Interaction with histone H3 is strongly inhibited by methylation at lysine 4 (H3K4me)
3 PDB 3D structures from and Proteopedia for DNMT3L:
2PV0 (3D)        2PVC (3D)        2QRV (3D)    
Secondary accessions: E9PB42 Q9BUJ4
Alternative splicing: 2 isoforms:  Q9UJW3-1   Q9UJW3-2   

Explore the universe of human proteins at neXtProt for DNMT3L: NX_Q9UJW3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UJW3

    • DNMT3L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_037501.2  NP_787063.1  

    ENSEMBL proteins: 
     ENSP00000411608   ENSP00000270172   ENSP00000400242   ENSP00000412862  

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    Uscn Proteins for DNMT3L

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794condensed nuclear chromosome IEA--
    GO:0005634nucleus NAS12202768
    GO:0005720nuclear heterochromatin IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA16780588


    DNMT3L for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for DNMT3L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DNMT3L for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013083 Znf_RING/FYVE/PHD
     IPR025766 ADD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UJW3

    ProtoNet protein and cluster: Q9UJW3

    UniProtKB/Swiss-Prot: DNM3L_HUMAN, Q9UJW3
    Similarity: Belongs to the C5-methyltransferase family
    Similarity: Contains 1 ADD domain
    Similarity: Contains 1 GATA-type zinc finger
    Similarity: Contains 1 PHD-type zinc finger


    Function
    for DNMT3L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DNM3L_HUMAN, Q9UJW3
    Function: Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of
    DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA
    and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases.
    Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of
    DNMT3

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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12202768
    GO:0008047enzyme activator activity IDA16543361
    GO:0019899enzyme binding IPI12202768
    GO:0046872metal ion binding IEA--


    DNMT3L for ontologies           About GeneDecksing


    Animal Models:
         8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Dnmt3l):
     cardiovascular system  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging 
     nervous system  normal  reproductive system 

    DNMT3L for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DNMT3L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolic pathways0.38
    2Sulfur amino acid metabolism
    		Cysteine and methionine metabolism0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for DNMT3L):
        Cysteine and methionine metabolism
    Metabolic pathways


    DNMT3L for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DNMT3L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/38 Interacting proteins for DNMT3L (Q9UJW31, 2, 3 ENSP000002701724) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H4AP628053, ENSP000003581624I2D: score=1 STRING: ENSP00000358162
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001890placenta development IEA--
    GO:0006306DNA methylation NAS12202768
    GO:0006349regulation of gene expression by genetic imprinting NAS12202768
    GO:0007283spermatogenesis NAS11934864


    DNMT3L for ontologies           About GeneDecksing



    Drugs & Compounds
    for DNMT3L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DNMT3L for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DNMT3L

    2 HMDB Compounds for DNMT3L    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    3 Novoseek chemical compound relationships for DNMT3L gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytosine 48.2 5 19921333 (3), 12177302 (1)
    s-adenosylmethionine 39 9 15671018 (3), 16829525 (2)
    zinc 7.39 3 12177302 (1), 10857753 (1)

    Search CenterWatch for drugs/clinical trials and news about DNMT3L / DNM3L 

    Transcripts
    for DNMT3L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DNMT3L gene (2 alternative transcripts): 
    NM_013369.3  NM_175867.2  

    Unigene Cluster for DNMT3L:

    DNA (cytosine-5-)-methyltransferase 3-like
    Hs.592165  [show with all ESTs]
    Unigene Representative Sequence: NM_013369
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436357 ENST00000270172(uc002zeh.1) ENST00000431166 ENST00000418993(uc002zeg.1)


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF194032.1 BC002560.2 

    3 DOTS entries:

    DT.426886  DT.91751580  DT.87046632 

    24/48 AceView cDNA sequences (see all 48):

    BE732527 BI088085 BC002560 BE902138 BE278445 NM_175867 NM_013369 BG773923 
    BG774099 BE278718 AF194032 BE900930 BE281379 AI335740 BE734176 BE408417 
    BE732532 BE536693 BE903738 BG479125 BG773681 BG773701 BE280451 BE280360 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DNMT3L    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                    
    SP2:                                                                                    


    ECgene alternative splicing isoforms for DNMT3L

    Expression
    for DNMT3L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DNMT3L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTTGATGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DNMT3L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TrophoblastMural TrophectodermMural Trophectoderm CellsExtraembryonic Tissues
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See DNMT3L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DNMT3L

    SOURCE GeneReport for Unigene cluster: Hs.592165

    UniProtKB/Swiss-Prot: DNM3L_HUMAN, Q9UJW3
    Tissue specificity: Expressed at low levels in several tissues including testis, ovary, and thymus

        SABiosciences Expression via Pathway-Focused PCR Array including DNMT3L: 
              Polycomb & Trithorax Complexes in human mouse rat

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    In Situ
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    Orthologs
    for DNMT3L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DNMT3L gene from 2/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.208762 Xenopus laevis transcribed sequence with moderate similarity more 79.41(n)    BX846204.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 8(a)
    6(a)
    		 many ↔ many
    many ↔ many
    		 Group2.1(246578-252516)
    Group2.1(246777-305645)


    ENSEMBL Gene Tree for DNMT3L (if available)
    TreeFam Gene Tree for DNMT3L (if available) 

    Paralogs
    for DNMT3L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DNMT3L gene
    DNMT3A2  DNMT3B2  
    1 SIMAP similar gene for DNMT3L using alignment to 3 protein entries:     DNM3L_HUMAN (see all proteins):
    DNMT3A

    DNMT3L for paralogs           About GeneDecksing



    Genomic Variants
    for DNMT3L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/405 NCBI SNPs in DNMT3L are shown (see all 405)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1153413271,2
    		F,--45665724(+) TTCAGC/TAGGTC 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1480985411,2
    		--45665873(+) CATGCA/GGGACA 2 -- ds50010--------
    rs782137881,2
    		--45665880(+) GACACA/GGTGCA 2 -- ds50010--------
    rs1913551541,2
    		--45665883(+) ACGGTA/GCAGGC 2 -- ds50010--------
    rs1461000391,2
    		--45665893(+) CGCTCC/GGAAGA 2 -- ds50010--------
    rs1388844101,2
    		--45665925(+) CTCCAA/CCCCCT 2 -- ds50010--------
    rs1421097481,2
    		--45665932(+) CCCTGC/TCCTGC 2 -- ds50010--------
    rs81268991,2
    		C,F,--45666041(+) TGCTTT/CCAGGA 2 -- ds50014Minor allele frequency- C:0.17WA CSA 124
    rs117006471,2
    		C,H,--45666245(+) TTCTAA/GGAAAA 2 -- ut31 ese30--------
    rs1839406101,2
    		C,--45666268(+) ACAGTA/GTAGTG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DNMT3L (45666222 - 45682099 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for DNMT3L
         2 CNVs: 7327 67805
    Human Gene Mutation Database (HGMD): DNMT3L

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    Disorders / Diseases
    for DNMT3L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DNMT3L for disorders           About GeneDecksing

    OMIM gene information: 606588    OMIM disorders: --

    10 diseases for DNMT3L:    About MalaCards
    silver-russell syndrome    beckwith-wiedemann syndrome    alpha thalassemia    epithelial ovarian cancer
    thalassemia    embryonal carcinoma    ovarian cancer    cervical cancer
    cervicitis    carcinoma

    1 disease from the University of Copenhagen DISEASES database for DNMT3L:
    Testis seminoma
    Human Genome Epidemiology (HuGE) Navigator: DNMT3L (5 documents)

    Export disorders for DNMT3L gene to outside databases

    Publications
    for DNMT3L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DNMT3L gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with DNMT3L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. (PubMed id 10857753)1, 2, 3, 9 Aapola U.... Peterson P. (2000)
    2. Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. (PubMed id 17713477)1, 2, 9 Jia D....Cheng X. (2007)
    3. DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. (PubMed id 17687327)1, 2, 9 Ooi S.K....Bestor T.H. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. DNA methyltransferase 3-like affects promoter methyla tion of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cel ls. (PubMed id 20428781)1, 9 Kim H....Kim T.Y. (2010)
    7. Reconstitution and mechanism of the stimulation of de novo methylation by human DNMT3L. (PubMed id 16829525)1, 9 Kareta M.S....Chedin F. (2006)
    8. Dnmt3L is a transcriptional repressor that recruits histone deacetylase. (PubMed id 12202768)1, 9 Deplus R....Fuks F. (2002)
    9. Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family. (PubMed id 15861382)1, 9 Chen Z.X....Chedin F. (2005)
    10. Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. (PubMed id 12177302)1, 9 Aapola U....Peterson P. (2002)

    External Searches for DNMT3L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing DNMT3L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29947 HGNC: 2980 AceView: DNMT3L Ensembl:ENSG00000142182 euGenes: HUgn29947
    ECgene: DNMT3L Kegg: 29947 H-InvDB: DNMT3L

    Other Databases showing DNMT3L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DNMT3L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DNMT3L Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DNMT3L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DNMT3L gene:
    Search GeneIP for patents involving DNMT3L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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