Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNMT3B Gene

protein-coding GIFtS: 72
GCID: GC20P031350

DNA (cytosine-5-)-methyltransferase 3 beta

Explore 74 diseases affiliated with
DNMT3B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DNA (Cytosine-5-)-Methyltransferase 3 Beta¹ ²		ICF² ⁵
M.HsaIIIB² ³		ICF1²
DNA Methyltransferase HsaIIIB² ³		DNA (Cytosine-5)-Methyltransferase 3B²
DNA MTase HsaIIIB² ³		Dnmt3b³
EC 2.1.1.37³ ⁸

External Ids:	HGNC: 2979¹	Entrez Gene: 1789²	Ensembl: ENSG00000088305⁷	OMIM: 602900⁵	UniProtKB: Q9UBC3³

Export aliases for DNMT3B gene to outside databases

Previous GC identifers: GC20P031108 GC20P032018 GC20P032065 GC20P030813 GC20P028137

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNMT3B:

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome

inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene

encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance

methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations

in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively

spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been

determined. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: DNM3B_HUMAN, Q9UBC3

Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation

patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially

methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by

associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In

association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by

modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to

the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with

ZHX1

summary for DNMT3B:

DNA methyltransferase (DNMT) add methyl groups to DNA to effect gene expression. There are three types of

DNMTs. DNMT1 is predominately responsible for hemimethylated CpG island methylation, DNMT2 in fact transfers

methyl groups to RNA not DNA, hence has been renamed to tRNA aspartic acid methyltransferase 1 (TRDMT1) and

DNMT3 is responsible for unmethylated CpG island methylation.

Gene Wiki entry for DNMT3B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNMT3B gene promoter:
Lmo2 Olf-1 MyoD
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DNMT3B promoter sequence

Search SABiosciences Chromatin IP Primers for DNMT3B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNMT3B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.2 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11.2

DNMT3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNMT3B gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P031350: view genomic region (about GC identifiers)

Start:	31,350,191 bp from pter	End:	31,397,162 bp from pter
Size:	46,972 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNM3B_HUMAN, Q9UBC3 (See protein sequence)

Recommended Name: DNA (cytosine-5)-methyltransferase 3B

Size: 853 amino acids; 95751 Da

Subunit: Interacts with BAZ2A/TIP5, SUV39H1 and CBX4. Interacts with UHRF1 (By similarity). Interacts with DNMT1 and

DNMT3A, SETDB1, UBL1, UBE2I9 and ZHX1. Interacts with the PRC2/EED-EZH2 complex

Subcellular location: Nucleus

2 PDB 3D structures from and Proteopedia for DNMT3B:

3FLG (3D)

3QKJ (3D)

Secondary accessions: A2A2E2 B4DSM8 B4DSU1 E1P5M6 E1P5M7 E7EN63 E9PBF2 Q9UBD4 Q9UJQ5 Q9UKA6 Q9UNE5

Q9Y5R9 Q9Y5S0

Alternative splicing: 8 isoforms: Q9UBC3-1 Q9UBC3-2 Q9UBC3-3 Q9UBC3-4 Q9UBC3-5 Q9UBC3-6 Q9UBC3-7 Q9UBC3-8

(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DNMT3B: NX_Q9UBC3

Post-translational modifications:

Sumoylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBC3

4/13 DME Specific Peptides for DNMT3B (Q9UBC3) (see all 13)

FENVVAM

HYTDVSNM

SNSIKQGK

DGYQSYCT

DNMT3B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001193984.1 NP_001193985.1 NP_008823.1 NP_787044.1 NP_787045.1 NP_787046.1

ENSEMBL proteins:

ENSP00000328547 ENSP00000313397 ENSP00000337764 ENSP00000201963 ENSP00000403169

ENSP00000412305 ENSP00000345105 ENSP00000364774

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DNMT3B OriGene Protein Over-expression Lysate (see all 2): DNMT3B OriGene Custom Protein Services for DNMT3B
	GenScript Custom Purified and Recombinant Proteins Services for DNMT3B
	Novus Biologicals DNMT3B Protein Novus Biologicals DNMT3B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DNMT3B

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	--	--
GO:0000792	heterochromatin	--	--
GO:0005634	nucleus	IDA	--
GO:0005720	nuclear heterochromatin	IEA	--
GO:0005730	NOT nucleolus	IDA	--

DNMT3B for ontologies About GeneDecksing

DNMT3B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DNMT3B
	R&D Systems Antibodies for DNMT3B
	OriGene Antibodies: DNMT3B OriGene Custom Antibody Services for DNMT3B
	GenScript Custom Superior Antibodies Services for DNMT3B
	Novus Biologicals DNMT3B Antibodies
	Abcam antibodies for DNMT3B
	Uscn Antibodies for DNMT3B
	ThermoFisher Antibody for DNMT3B

Assay Products for DNMT3B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DNMT3B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DNMT3B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNMT3B for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR025811 C5_MeTrfase_3

IPR018117 C5_DNA_meth_AS

IPR001525 C5_MeTfrase

IPR025766 ADD

IPR000313 PWWP

Graphical View of Domain Structure for InterPro Entry Q9UBC3

ProtoNet protein and cluster: Q9UBC3

2 Blocks protein families:

IPB000313 PWWP domain

IPB001525 C-5 cytosine-specific DNA methylase

UniProtKB/Swiss-Prot: DNM3B_HUMAN, Q9UBC3

Domain: The PWWP domain is essential for targeting to pericentric heterochromatin

Similarity: Belongs to the C5-methyltransferase family

Similarity: Contains 1 ADD domain

Similarity: Contains 1 GATA-type zinc finger

Similarity: Contains 1 PHD-type zinc finger

Similarity: Contains 1 PWWP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DNM3B_HUMAN, Q9UBC3

Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation

patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially

methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by

associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In

association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by

modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to

the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with

ZHX1

Catalytic activity: S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine

Enzyme regulation: Activated by binding to the regulatory factor DNMT3L (By similarity)

Genatlas biochemistry entry for DNMT3B:

DNA (cytosine -5)-methyltransferase 3 beta ,abundantly expressed in ES cells in testis and thymus but barely detectable

in differentiated cells and adult tissues,with at least two alternatively spliced isoforms essential for de novo DNA

methylation and development (at least in mouse)

Enzyme Number (IUBMB): EC 2.1.1.37¹ ²

miRNA Products:		miRTarBase miRNAs that target DNMT3B: hsa-mir-369-5p (MIRT005961), hsa-mir-29c (MIRT003025), hsa-mir-148a (MIRT000955), hsa-mir-29a (MIRT003027), hsa-mir-29b (MIRT003026)

		OriGene 3'-UTR Clone (see all 4): DNMT3B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNMT3B
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate DNMT3B (see all 48):
		hsa-miR-429 hsa-miR-4328 hsa-miR-29a hsa-miR-3921 hsa-miR-124 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: DNMT3B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNMT3B (see all 7) OriGene shRNA RFP: DNMT3B OriGene siRNA: DNMT3B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNMT3B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DNMT3B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3B (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3B (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): DNMT3B (NM_006892)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNMT3B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNMT3B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNMT3B
		Search LifeMap BioReagents cell lines for DNMT3B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNMT3B

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003714	transcription corepressor activity	IMP	18567530
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	TAS	10433969
GO:0005515	protein binding	IPI	--
GO:0008168	methyltransferase activity	--	--

DNMT3B for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for DNMT3B:

Increased G1 DNA content

Increased cell death HMECs cel

Increased cell death in breast

Animal Models:
Mouse knock-outs for DNMT3B: Dnmt3b^tm5.2Enl Dnmt3b^tm2Enl
15 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Dnmt3b):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size
hematopoietic system	immune system	liver/biliary system	mortality/aging	nervous system
no phenotypic analysis	reproductive system	skeleton	tumorigenesis	vision/eye

DNMT3B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Methionine metabolism

Methionine metabolism

1.00

Methionine metabolism

1.00

Selected targets of Oct-3/4

Selected targets of Oct-3/4

1.00

One Carbon Metabolism

One Carbon Metabolism

1.00

DNA Methylation and Transcriptional Repression

DNA Methylation and Transcriptional Repression

1.00

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DNMT3B

	Selected targets of Oct-3/4
	Methionine metabolism

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DNMT3B

DNA Methylation and Transcriptional Repression

1 GeneGo (Thomson Reuters) Pathway for DNMT3B

Methionine metabolism

1 BioSystems Pathway for DNMT3B

One Carbon Metabolism

2 Kegg Pathways (Kegg details for DNMT3B):

	Cysteine and methionine metabolism
	Metabolic pathways

DNMT3B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DNMT3B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/75 Interacting proteins for DNMT3B (Q9UBC3^{1, 2, 3} ENSP00000328547⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 75)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UHRF1	Q96T88²^,³	MINT-7296336 MINT-7296510 MINT-7296314 MINT-7296421 MINT-7296305 MINT-7296379 MINT-7296468 I2D: score=2
DNMT3A	Q9Y6K1²^,³, ENSP00000264709⁴	MINT-7296314 MINT-6178415 MINT-6178447 MINT-7296379 MINT-6178404 I2D: score=2 STRING: ENSP00000264709
UBE2I	P63279¹^,³, ENSP00000324897⁴	EBI-80125,EBI-80168 I2D: score=4 STRING: ENSP00000324897
EED	O75530¹^,³, ENSP00000263360⁴	EBI-80125,EBI-1177693 I2D: score=3 STRING: ENSP00000263360
EZH2	Q15910¹^,³, ENSP00000320147⁴	EBI-80125,EBI-746496 I2D: score=3 STRING: ENSP00000320147

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA	17303076
GO:0006306	DNA methylation	TAS	10433969
GO:0006346	methylation-dependent chromatin silencing	IEA	--
GO:0006349	regulation of gene expression by genetic imprinting	IEA	--
GO:0010212	response to ionizing radiation	--	--

DNMT3B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DNMT3B for compounds About GeneDecksing

EMD Millipore small molecules for DNMT3B:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for DNMT3B available from Tocris Bioscience About this table

Compound	Action	CAS #
RG 108	Non-nucleoside DNA methyltransferase inhibitor	[48208-26-0]
Zebularine	DNA methyltransferase and cytidine deaminase inhibitor	[3690-10-6]
Decitabine	DNA methyltransferase inhibitor	[2353-33-5]
5-Azacytidine	DNA methyltransferase inhibitor	[320-67-2]

3 HMDB Compounds for DNMT3B About this table

Compound	Synonyms	CAS #	PubMed Ids
5-Methylcytosine	4-Amino-5-methyl-2-pyrimidinol (see all 5)	554-01-8	--
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

10/11 Novoseek chemical compound relationships for DNMT3B gene (see all 11) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine	87	24	19306077 (4), 20372798 (2), 16977793 (1), 12665573 (1) (see all 13)
5-methylcytosine	74.1	1	12242669 (1)
cytosine	72.2	4	17178860 (1), 12177302 (1), 11531283 (1)
zebularine	59.5	1	16807237 (1)
arsenite	26.8	1	19679824 (1)
folate	20.5	1	19451595 (1)
tamoxifen	6.37	7	19019622 (5), 14555514 (1)
homocysteine	0	2	17688412 (2)
oligonucleotide	0	2	15362956 (1), 11741835 (1)
zinc	0	2	19128516 (1), 10857753 (1)

Search CenterWatch for drugs/clinical trials and news about DNMT3B / DNM3B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNMT3B gene (6 alternative transcripts):

NM_001207055.1 NM_001207056.1 NM_006892.3 NM_175848.1 NM_175849.1 NM_175850.2

Unigene Clusters for DNMT3B:

DNA (cytosine-5-)-methyltransferase 3 beta

Hs.643024 [show with all ESTs], Hs.713611 [show with all ESTs]

Unigene Representative Sequences: BQ222535, DQ321787

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000328111(uc010ztx.1 uc010zty.1 uc002wyc.3 uc002wyd.3 uc002wye.3 uc010ztz.2 uc010zua.2 uc010gee.3 uc010gef.3 uc002wyg.3)

ENST00000353855(uc010geg.3 uc010geh.3) ENST00000348286 ENST00000201963(uc002wyf.3)

ENST00000443239 ENST00000456297 ENST00000344505 ENST00000375623

miRNA Products:		OriGene 3'-UTR Clone (see all 4): DNMT3B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNMT3B
		8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate DNMT3B (see all 48):
		hsa-miR-429 hsa-miR-4328 hsa-miR-29a hsa-miR-3921 hsa-miR-124 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-506

		SwitchGear 3'UTR luciferase reporter plasmid: DNMT3B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNMT3B (see all 7) OriGene shRNA RFP: DNMT3B OriGene siRNA: DNMT3B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNMT3B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3B (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3B (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): DNMT3B (NM_006892)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNMT3B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNMT3B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNMT3B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNMT3B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNMT3B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNMT3B

Additional cDNA sequence:

AB208880.1 AF129267.1 AF129268.1 AF129269.1 AF156487.1 AF156488.1 AF176228.1 AF331857.1

AK001191.1 AK295176.1 AK299776.1 AK299821.1 AK299915.1 AK300857.1 DQ321787.1

14 DOTS entries:

DT.113253 DT.113255 DT.100781518 DT.120812129 DT.100781515 DT.100781514 DT.40118740 DT.100730319

DT.102842807 DT.97812649 DT.100730272 DT.102842808 DT.91846915 DT.102842804

24/103 AceView cDNA sequences (see all 103):

AF176228 CK825649 BE046956 BQ277772 AF129268 AA565566 NM_006892 AF129269

AF331857 NM_175849 BU850032 BU854958 CD654323 AA206264 CR609754 AL120820

AI114879 AF129267 AI954642 NM_175850 NM_175848 BM834719 AI332472 BM677321

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DNMT3B (see all 17) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15	^	16a	·
SP1:																											-						-						-
SP2:																																	-						-
SP3:
SP4:
SP5:																											-						-				-		-

ExUns:	16b	·	16c	^	17	^	18a	·	18b	·	18c	^	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23a	·	23b	^	24a	·	24b	·	24c
SP1:
SP2:
SP3:
SP4:																									-
SP5:

ECgene alternative splicing isoforms for DNMT3B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNMT3B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCTACAGG

About this image

DNMT3B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/18 LifeMap Cells (see all 18)

Name

Category

Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)

Early Embryo, Fibroblast

BG01V (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

CA1 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

CA2 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

VUB02 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

VUB03_DM1 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

VUB04_CF (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

VUB07 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

VUB09_FSHD (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

FES22 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See DNMT3B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNMT3B

SOURCE GeneReport for Unigene clusters: Hs.643024 Hs.713611

UniProtKB/Swiss-Prot: DNM3B_HUMAN, Q9UBC3

Tissue specificity: Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in

spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1

is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues

except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and

prostate

SABiosciences Expression via Pathway-Focused PCR Arrays including DNMT3B:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Cell Lineage Identification in human mouse rat

Stem Cell Transcription Factors in human mouse rat

Polycomb & Trithorax Complexes in human mouse rat

Embryonic Stem Cells in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNMT3B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNMT3B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNMT3B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNMT3B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNMT3B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DNMT3B gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dnmt3b^{1 , 5}	DNA methyltransferase 3B^{1, 5}	83.47(n)¹ 85.26(a)¹		2 (75.79 cM)⁵ 13436¹ NM_001122997.1¹ NP_001116469.1¹ 153649450⁵
chicken (Gallus gallus)	Aves	DNMT3B¹	DNA (cytosine-5-)-methyltransferase 3 beta	68.34(n) 65.85(a)		419287 NM_001024828.1 NP_001019999.1
lizard (Anolis carolinensis)	Reptilia	DNMT3B⁶	--	81(a)	1 ↔ 1	GL343873.1(121908-140319)
zebrafish (Danio rerio)	Actinopterygii	AF135438.1²	--	77.26(n)		30659 AF135438.1
honey bee (Apis mellifera)	Insecta	-- --	--	23(a) 19(a)	many ↔ many many ↔ many	Group2.1(246578-252516) Group2.1(246777-305645)

ENSEMBL Gene Tree for DNMT3B (if available)
TreeFam Gene Tree for DNMT3B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNMT3B gene

DNMT3A² DNMT3L²

1 SIMAP similar gene for DNMT3B using alignment to 3 protein entries: DNM3B_HUMAN (see all proteins):

DNMT3A

DNMT3B for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DNMT3B
PGOHUM00000240078

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73112116^1,2	C,F,	--	28137809(+)	`CGGACC/GCTGCT`	5	--	int¹		1		NA	120
rs73112119^1,2	C,	--	28137947(+)	`AGGGGG/AACGCG`	5	--	int¹		2		NA	122
rs77590300^1,2	C,F,	--	28137951(+)	`GGACGC/AGCTGG`	5	--	int¹		1		WA	118
rs73112121^1,2	C,	--	28138021(+)	`TTGCTA/CATGGG`	5	--	int¹		0	--	--	--	--
rs111593183^1,2		--	28138425(+)	`ACTCCC/TGTGTG`	5	--	int¹		1		CSA	2
rs80310311^1,2	F,	--	28138587(+)	`ACAAGT/CTGTAA`	5	--	int¹		1		EA	120
rs75138939^1,2	F,	--	28138633(+)	`AGGATC/TTCACC`	5	--	int¹		1		NA	120
rs73258122^1,2	C,	--	28138761(+)	`AGCTGG/CGAAGT`	5	--	int¹		1		WA	2
rs59507494^1,2	C,F,	--	28139018(+)	`GCCATT/CGTTGG`	5	--	int¹		4		WA CSA NA	242
rs7508830^1,2	H	--	28139834(+)	`AGCCAC/AGTGGG`	5	--	int¹		4		NS EA	420

HapMap Linkage Disequilibrium report for DNMT3B (31350191 - 31397162 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DNMT3B
1 CNV: 5133
Human Gene Mutation Database (HGMD): DNMT3B

Locus Specific Mutation Databases (LSDB): DNMT3B

SABiosciences Cancer Mutation PCR Assays

2 SABiosciences qBiomarker Copy Number PCR Arrays containing DNMT3B:

Oncogenes & Tumor Suppressor Genes 384HC

Pancreatic Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNMT3B

DNA2.0 Custom Variant and Variant Library Synthesis for DNMT3B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DNMT3B for disorders           About GeneDecksing

OMIM gene information: 602900
OMIM disorders: 242860
UniProtKB/Swiss-Prot: DNM3B_HUMAN, Q9UBC3

Defects in DNMT3B are a cause of immunodeficiency-centromeric instability-facial anomalies syndrome type 1

(ICF1) [MIM:242860]. A rare disorder characterized by a variable immunodeficiency, facial anomalies, and branching of

chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor

retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not

all, patients

20/74 diseases for DNMT3B (see all 74): About MalaCards

immunodeficiency diffuse large b-cell lymphoma b-cell lymphomas mutagen sensitivity

testicular germ cell tumor malignant pleural mesothelioma germ cell tumor x inactivation

adenoid cystic carcinoma squamous cell carcinoma of the head and neck systemic lupus erythematosus squamous cell carcinoma

lupus erythematosus myelodysplastic syndrome transitional cell carcinoma acute lymphoblastic leukemia

chronic lymphocytic leukemia lymphoblastic leukemia acute myeloid leukemia carcinoma

1 disease from the University of Copenhagen DISEASES database for DNMT3B:

Cancer

10/35 Novoseek disease relationships for DNMT3B gene (see all 35) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
icf syndrome	95.5	37	18762900 (3), 18029387 (3), 15326630 (2), 10588719 (2) (see all 21)
cancer	58.1	58	15721400 (4), 15661247 (4), 12015329 (3), 18455294 (2) (see all 27)
tumors	49.5	54	17067458 (2), 18097598 (2), 18563322 (2), 15661247 (2) (see all 31)
immunodeficiency	45.6	31	20211012 (2), 10588719 (2), 18432406 (2), 11087891 (1) (see all 21)
colon cancer	39.3	8	19723660 (2), 15547111 (1), 19156137 (1), 12496760 (1) (see all 6)
purpura thrombocytopenic idiopathic	38.2	2	18437543 (2)
colorectal cancer	35.7	19	19470733 (4), 16702365 (3), 18662374 (2), 18089774 (1) (see all 8)
hepatocellular carcinoma	31.9	19	16318277 (5), 19567080 (3), 19465161 (2), 18023104 (2) (see all 7)
gastric cancer	31.3	22	16211278 (5), 20127025 (3), 19517237 (3), 11146446 (2) (see all 5)
endometrial cancer	29.5	11	15661247 (4), 19306077 (2), 19107573 (1)

Genetic Association Database (GAD): DNMT3B
Human Genome Epidemiology (HuGE) Navigator: DNMT3B (50 documents)

Export disorders for DNMT3B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNMT3B gene, integrated from 9 sources (see all 369):
(articles sorted by number of sources associating them with DNMT3B)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, expression and chromosome locations of the human DNMT3 gene family. (PubMed id 10433969)^{1, 2, 3, 9} Xie S....Li E. (1999)
DNMT3B polymorphisms and risk of primary lung cancer. (PubMed id 15528220)^{1, 4, 9} Lee S.J....Park J.Y. (2005)
No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population. (PubMed id 16211278)^{1, 4, 9} Aung P.P....Yasui W. (2005)
The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. (PubMed id 10588719)^{1, 2, 9} Hansen R.S.... Gartler S.M. (1999)
Genetic variation in ICF syndrome: evidence for genetic heterogeneity. (PubMed id 11102980)^{1, 2, 9} Wijmenga C.... Pearson P.L. (2000)
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk. (PubMed id 16012746)^{1, 4, 9} Singal R....Schlesselman J.J. (2005)
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. (PubMed id 10555141)^{1, 2, 9} Okano M.... Li E. (1999)
DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription. (PubMed id 18567530)^{1, 2, 9} Kim S.-H.... Kim T.-Y. (2008)
Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China. (PubMed id 15962389)^{1, 4, 9} Wang Y.M....Zhang J.H. (2005)
DNMT3B mutations and DNA methylation defect define two types of ICF syndrome. (PubMed id 15580563)^{1, 2, 9} Jiang Y.L.... Viegas-Pequignot E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1789	HGNC: 2979	AceView: DNMT3B	Ensembl:ENSG00000088305	euGenes: HUgn1789
ECgene: DNMT3B	Kegg: 1789	H-InvDB: DNMT3B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DNMT3B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DNMT3B	Genetics and Cytogenetics in Oncology and Haematology
DNMT3Bbase	http://bioinf.uta.fi/DNMT3Bbase/

Intellectual Property for DNMT3B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DNMT3B gene:
Search GeneIP for patents involving DNMT3B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore small molecules (inhibitor) for DNMT3B
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of DNMT3B
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for DNMT3B (DNMT3B)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for DNMT3B		OriGene shRNA RFP for DNMT3B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNMT3B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNMT3B
	OriGene Protein Over-expression Lysate for DNMT3B		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DNMT3B		OriGene 3'-UTR Clone for DNMT3B
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3B		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3B
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for DNMT3B		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DNMT3B		OriGene Custom Protein Services for DNMT3B
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNMT3B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNMT3B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNMT3B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNMT3B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNMT3B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNMT3B

	GenScript Custom Purified and Recombinant Proteins Services for DNMT3B		GenScript cDNA clones with any tag delivered in your preferred vector for DNMT3B
	GenScript Custom Assay Services for DNMT3B		GenScript Custom Superior Antibodies Services for DNMT3B
	GenScript Custom overexpressing Cell Line Services for DNMT3B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DNMT3B promoter
	Search Chromatin IP Primers for DNMT3B
	RT² qPCR Primer Assay in human, mouse, rat DNMT3B
	GNC Network for DNMT3B
	SABiosciences PCR Arrays including human, mouse, rat DNMT3B

Tocris compounds for DNMT3B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DNMT3B antibodies
	DNMT3B proteins
	DNMT3B lysates

	Antibodies for DNMT3B
	See all of Abcam's Antibodies, Kits and Proteins for DNMT3B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

DNMT3B Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DNMT3B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNMT3B

	SwitchGear 3'UTR luciferase reporter plasmids for DNMT3B
	SwitchGear Promoter luciferase reporter plasmids for DNMT3B

ThermoFisher Antibody for DNMT3B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNMT3B

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DNMT3B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

DNMT3B Gene

DNA (cytosine-5-)-methyltransferase 3 beta

Aliases
for DNMT3B gene

Summaries
for DNMT3B gene

Genomic Views
for DNMT3B gene

Proteins
for DNMT3B gene

Protein Domains /
Families
for DNMT3B gene

Function
for DNMT3B gene

Pathways & Interactions
for DNMT3B gene

Drugs & Compounds
for DNMT3B gene

Transcripts
for DNMT3B gene

Expression
for DNMT3B gene

Orthologs
for DNMT3B gene

Paralogs
for DNMT3B gene

Genomic Variants
for DNMT3B gene

Disorders / Diseases
for DNMT3B gene

Publications
for DNMT3B gene

External Searches for DNMT3B gene

Genome Databases showing DNMT3B gene

Other Databases showing DNMT3B gene

Specialized Databases showing DNMT3B gene

Intellectual Property
for DNMT3B gene

Products
for DNMT3B gene

View Random Gene

Gastric Cancer
Cirrhosis
BREAST CARCINOMA
Colon Cancer
bladder cancer
Hepatitis Chronic
Carcinoma
ACUTE LEUKEMIA
Leukemia
Lymphatic Metastasis
Purpura Thrombocytopenic Idiopathic
Breast Cancer
NSCLC
primary tumor
Adenocarcinoma
HEPATOCELLULAR CARCINOMA
Neck Cancer
Cancer
Cancer Lung
small cell lung cancer
Ovarian Cancer
NASOPHARYNGEAL CARCINOMA
benign prostatic hyperplasia
Colorectal Cancer
ICF SYNDROME
HNSCC
Carcinoma Squamous Cell
immunodeficiency
prostate cancer
Tumors
Mental Retardation
Metastasis
genetic disorder
Myelodysplastic Syndromes
Endometrial Cancer

Advanced Search

Export list of displayed genes

DNMT3B Gene

DNA (cytosine-5-)-methyltransferase 3 beta

Aliasesfor DNMT3B gene

Summariesfor DNMT3B gene

Genomic Viewsfor DNMT3B gene

Proteinsfor DNMT3B gene

Protein Domains /Familiesfor DNMT3B gene

Functionfor DNMT3B gene

Pathways & Interactionsfor DNMT3B gene

Drugs & Compoundsfor DNMT3B gene

Transcriptsfor DNMT3B gene

Expression for DNMT3B gene

Orthologsfor DNMT3B gene

Paralogsfor DNMT3B gene

Genomic Variantsfor DNMT3B gene

Disorders / Diseasesfor DNMT3B gene

Publicationsfor DNMT3B gene

External Searches for DNMT3B gene

Genome Databases showing DNMT3B gene

Other Databases showing DNMT3B gene

Specialized Databases showing DNMT3B gene

Intellectual Propertyfor DNMT3B gene

Productsfor DNMT3B gene

View Random Gene

Aliases
for DNMT3B gene

Summaries
for DNMT3B gene

Genomic Views
for DNMT3B gene

Proteins
for DNMT3B gene

Protein Domains /
Families
for DNMT3B gene

Function
for DNMT3B gene

Pathways & Interactions
for DNMT3B gene

Drugs & Compounds
for DNMT3B gene

Transcripts
for DNMT3B gene

Expression
for DNMT3B gene

Orthologs
for DNMT3B gene

Paralogs
for DNMT3B gene

Genomic Variants
for DNMT3B gene

Disorders / Diseases
for DNMT3B gene

Publications
for DNMT3B gene

Intellectual Property
for DNMT3B gene

Products
for DNMT3B gene