Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DNMT3A Gene

protein-coding GIFtS: 70
GCID: GC02M025455

DNA (cytosine-5-)-methyltransferase 3 alpha

Explore 57 diseases affiliated with
DNMT3A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DNA (Cytosine-5-)-Methyltransferase 3 Alpha¹ ²		DNA (Cytosine-5)-Methyltransferase 3A²
M.HsaIIIA² ³		DNA Cytosine Methyltransferase 3A2²
DNA MTase HsaIIIA² ³		Dnmt3a³
EC 2.1.1.37³ ⁸		DNA Methyltransferase HsaIIIA³
DNMT3A2²

External Ids:	HGNC: 2978¹	Entrez Gene: 1788²	Ensembl: ENSG00000119772⁷	OMIM: 602769⁵	UniProtKB: Q9Y6K1³

Export aliases for DNMT3A gene to outside databases

Previous GC identifers: GC02M025377 GC02M025548 GC02M025430 GC02M025367 GC02M025194

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DNMT3A:

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome

inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene

encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance

methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated.

Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: DNM3A_HUMAN, Q9Y6K1

Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation

patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a

non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal

cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of

most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress

transcription through the recruitment of HDAC activity (By similarity)

summary for DNMT3A:

DNA methyltransferase (DNMT) add methyl groups to DNA to effect gene expression. There are three types of

DNMTs. DNMT1 is predominately responsible for hemimethylated CpG island methylation, DNMT2 in fact transfers

methyl groups to RNA not DNA, hence has been renamed to tRNA aspartic acid methyltransferase 1 (TRDMT1) and

DNMT3 is responsible for unmethylated CpG island methylation.

Gene Wiki entry for DNMT3A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DNMT3A gene promoter:
p53 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): DNMT3A promoter sequence

Search SABiosciences Chromatin IP Primers for DNMT3A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNMT3A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23

DNMT3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DNMT3A gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M025455: view genomic region (about GC identifiers)

Start:	25,455,845 bp from pter	End:	25,565,459 bp from pter
Size:	109,615 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DNM3A_HUMAN, Q9Y6K1 (See protein sequence)

Recommended Name: DNA (cytosine-5)-methyltransferase 3A

Size: 912 amino acids; 101858 Da

Subunit: Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L). Interacts

with UBC9, PIAS1 and PIAS2 (By similarity). Binds the ZNF238 transcriptional repressor. Interacts with SETDB1.

Associates with HDAC1 through its ADD domain. Interacts with UHRF1 (By similarity). Interacts with DNMT1 and DNMT3B.

Interacts with the PRC2/EED-EZH2 complex. Interacts with MPHOSPH8. Interacts with histone H3 that is not methylated at

'Lys-4' (H3K4)

Subcellular location: Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric

heterochromatin (By similarity)

Caution: It is uncertain whether Met-1 or Met-4 is the initiator

Sequence caution: Sequence=AAL57039.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=AAN40037.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

5 PDB 3D structures from and Proteopedia for DNMT3A:

2QRV (3D)

3A1A (3D)

3A1B (3D)

3LLR (3D)

3SVM (3D)

Secondary accessions: E9PEB8 Q86TE8 Q86XF5 Q8IZV0 Q8WXU9

Alternative promoter usage, Alternative splicing: 3 isoforms: Q9Y6K1-1 Q9Y6K1-2 Q9Y6K1-3 (Produced by alternative splicing)

Explore the universe of human proteins at neXtProt for DNMT3A: NX_Q9Y6K1

Post-translational modifications:

Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress

transcription (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6K1

4/21 DME Specific Peptides for DNMT3A (Q9Y6K1) (see all 21)

FENVVAM

EEASPPA

NPYKEVYT

VATTPEPV

DNMT3A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_072046.2 NP_715640.2 NP_783328.1 NP_783329.1

ENSEMBL proteins:

ENSP00000370122 ENSP00000324375 ENSP00000264709 ENSP00000370132 ENSP00000384237

ENSP00000384852

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DNMT3A OriGene Protein Over-expression Lysate (see all 3): DNMT3A OriGene Custom Protein Services for DNMT3A
	GenScript Custom Purified and Recombinant Proteins Services for DNMT3A
	Novus Biologicals DNMT3A Proteins Novus Biologicals DNMT3A Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DNMT3A

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	IEA	--
GO:0000791	euchromatin	IDA	12138111
GO:0000792	heterochromatin	--	--
GO:0005634	nucleus	IDA	--
GO:0005720	nuclear heterochromatin	IEA	--

DNMT3A for ontologies About GeneDecksing

DNMT3A Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DNMT3A
	R&D Systems Antibodies for DNMT3A
	Cell Signaling Technology (CST) Antibodies for DNMT3A
	OriGene Antibodies (see all 2): DNMT3A OriGene Custom Antibody Services for DNMT3A
	GenScript Custom Superior Antibodies Services for DNMT3A
	Novus Biologicals DNMT3A Antibodies
	Abcam antibodies for DNMT3A
	Uscn Antibodies for DNMT3A
	ThermoFisher Antibody for DNMT3A

Assay Products for DNMT3A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DNMT3A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DNMT3A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DNMT3A for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR025811 C5_MeTrfase_3

IPR018117 C5_DNA_meth_AS

IPR001525 C5_MeTfrase

IPR025766 ADD

IPR000313 PWWP

Graphical View of Domain Structure for InterPro Entry Q9Y6K1

ProtoNet protein and cluster: Q9Y6K1

1 Blocks protein family: IPB000313 PWWP domain

UniProtKB/Swiss-Prot: DNM3A_HUMAN, Q9Y6K1

Domain: The PWWP domain is essential for targeting to pericentric heterochromatin

Similarity: Belongs to the C5-methyltransferase family

Similarity: Contains 1 ADD domain

Similarity: Contains 1 GATA-type zinc finger

Similarity: Contains 1 PHD-type zinc finger

Similarity: Contains 1 PWWP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DNM3A_HUMAN, Q9Y6K1

Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation

patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a

non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal

cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of

most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress

transcription through the recruitment of HDAC activity (By similarity)

Catalytic activity: S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine

Enzyme regulation: Activated by binding to the regulatory factor DNMT3L (By similarity)

Genatlas biochemistry entry for DNMT3A:

DNA (cytosine -5)-methyltransferase 3 alpha ,abundantly expressed in ES cells but at very low levels in differentiated

embryoid bodies or adult tissues,essential for de novo DNA methylation and development (at least in mouse)

Enzyme Number (IUBMB): EC 2.1.1.37¹ ²

miRNA Products:		miRTarBase miRNAs that target DNMT3A: hsa-mir-29c (MIRT003028), hsa-mir-143 (MIRT000716), hsa-mir-369-5p (MIRT005960), hsa-mir-29b (MIRT003029), hsa-mir-194 (MIRT005897), hsa-mir-29a (MIRT003021)

		OriGene 3'-UTR Clone (see all 3): DNMT3A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNMT3A
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate DNMT3A (see all 44):
		hsa-miR-194* hsa-miR-4307 hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-429 hsa-miR-199a-3p hsa-miR-29a hsa-let-7a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: DNMT3A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNMT3A (see all 7) OriGene shRNA RFP: DNMT3A OriGene siRNA: DNMT3A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNMT3A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DNMT3A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3A (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3A (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): DNMT3A (NM_153759)
		Sino Biological Human cDNA Clone for DNMT3A
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNMT3A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNMT3A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DNMT3A
		Search LifeMap BioReagents cell lines for DNMT3A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNMT3A

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	12138111
GO:0003682	chromatin binding	IEA	--
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	IDA	12138111
GO:0005515	protein binding	IPI	16682412
GO:0045322	unmethylated CpG binding	IEA	--

DNMT3A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for DNMT3A: Dnmt3a^tm3.2Enl Dnmt3a^tm2Enl Dnmt3a^tm1.1Jae
     11 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Dnmt3a):

behavior/neurological	cellular	embryogenesis	endocrine/exocrine gland	growth/size
homeostasis/metabolism	mortality/aging	muscle	nervous system	no phenotypic analysis
reproductive system

DNMT3A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Methionine metabolism

Methionine metabolism

1.00

Methionine metabolism

1.00

Selected targets of Oct-3/4

Selected targets of Oct-3/4

1.00

One Carbon Metabolism

One Carbon Metabolism

1.00

Validated targets of C-MYC transcriptional repression

Validated targets of C-MYC transcriptional repression

1.00

DNA Methylation and Transcriptional Repression

DNA Methylation and Transcriptional Repression

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for DNMT3A

	Selected targets of Oct-3/4
	Methionine metabolism

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DNMT3A

DNA Methylation and Transcriptional Repression

1 Cell Signaling Technology (CST) Pathway for DNMT3A

Chromatin Regulation / Acetylation

1 GeneGo (Thomson Reuters) Pathway for DNMT3A

Methionine metabolism

2 BioSystems Pathways for DNMT3A

	One Carbon Metabolism
	Validated targets of C-MYC transcriptional repression

2 Kegg Pathways (Kegg details for DNMT3A):

	Cysteine and methionine metabolism
	Metabolic pathways

DNMT3A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DNMT3A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/69 Interacting proteins for DNMT3A (Q9Y6K1^{1, 2, 3} ENSP00000264709⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 69)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3E	P68431³, ENSP00000353581⁴	I2D: score=2 STRING: ENSP00000353581
HIST1H3A	P68431³, ENSP00000350275⁴	I2D: score=2 STRING: ENSP00000350275
HIST1H3B	P68431³	I2D: score=2
HIST1H3C	P68431³	I2D: score=2
HIST1H3D	P68431³	I2D: score=2

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0006306	DNA methylation	IDA	12138111
GO:0006346	methylation-dependent chromatin silencing	IEA	--
GO:0006349	regulation of gene expression by genetic imprinting	TAS	12138111
GO:0007283	spermatogenesis	IEA	--

DNMT3A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DNMT3A for compounds About GeneDecksing

EMD Millipore small molecules for DNMT3A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for DNMT3A available from Tocris Bioscience About this table

Compound	Action	CAS #
RG 108	Non-nucleoside DNA methyltransferase inhibitor	[48208-26-0]
Zebularine	DNA methyltransferase and cytidine deaminase inhibitor	[3690-10-6]
Decitabine	DNA methyltransferase inhibitor	[2353-33-5]
5-Azacytidine	DNA methyltransferase inhibitor	[320-67-2]

3 HMDB Compounds for DNMT3A About this table

Compound	Synonyms	CAS #	PubMed Ids
5-Methylcytosine	4-Amino-5-methyl-2-pyrimidinol (see all 5)	554-01-8	--
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

8 Novoseek chemical compound relationships for DNMT3A gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
5-aza-2'deoxycytidine	79.8	13	20372798 (2), 12665573 (1), 17556066 (1), 17998942 (1) (see all 7)
5-methylcytosine	72.4	1	12242669 (1)
cytosine	66.3	12	19921333 (3), 15799776 (2), 19450891 (1), 12138111 (1) (see all 7)
s-adenosylmethionine	53.2	16	15671018 (3), 16829525 (2), 17107663 (1)
azathioprine	16	1	15547111 (1)
zinc	3.22	6	15362956 (1), 19139273 (1), 10857753 (1)
folate	2.03	1	19451595 (1)
oligonucleotide	0	2	15362956 (1), 15854647 (1)

Search CenterWatch for drugs/clinical trials and news about DNMT3A / DNM3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DNMT3A gene (4 alternative transcripts):

NM_022552.4 NM_153759.3 NM_175629.2 NM_175630.1

Unigene Cluster for DNMT3A:

DNA (cytosine-5-)-methyltransferase 3 alpha

Hs.515840 [show with all ESTs]

Unigene Representative Sequence: AB208833

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000380746(uc002rgb.3) ENST00000321117(uc002rgc.3) ENST00000264709(uc002rgd.3)

ENST00000380756(uc010eyi.3) ENST00000402667 ENST00000474887 ENST00000482935

ENST00000491288 ENST00000466601 ENST00000461228 ENST00000474807 ENST00000484184

ENST00000470983 ENST00000496570 ENST00000406659(uc002rgf.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): DNMT3A Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DNMT3A
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate DNMT3A (see all 44):
		hsa-miR-194* hsa-miR-4307 hsa-miR-3607-3p hsa-miR-19b-2* hsa-miR-429 hsa-miR-199a-3p hsa-miR-29a hsa-let-7a-2*

		SwitchGear 3'UTR luciferase reporter plasmid: DNMT3A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNMT3A (see all 7) OriGene shRNA RFP: DNMT3A OriGene siRNA: DNMT3A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNMT3A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3A (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3A (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): DNMT3A (NM_153759)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DNMT3A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNMT3A

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNMT3A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNMT3A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNMT3A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNMT3A

Additional cDNA sequence:

AB208833.1 AF067972.2 AF331856.1 AF480163.1 AK025230.1 BC018214.1 BC023612.2 BC032392.1

BC043617.1 BC051864.1

15 DOTS entries:

DT.95110184 DT.114106 DT.100749646 DT.92430946 DT.40285287 DT.100749645 DT.100662074 DT.99928292

DT.102823845 DT.121026073 DT.121026102 DT.100749647 DT.92430938 DT.97780601 DT.99954735

24/207 AceView cDNA sequences (see all 207):

BC023612 NM_175630 BM873445 AA969118 AI670957 AA364876 AI634419 BC018214

AI023308 BF223723 AF067972 AI092878 AW590851 BQ434593 AI971537 BE466006

AI861939 AA573317 CB852889 AI392759 W67657 AF480163 CR618290 BQ721518

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DNMT3A (see all 11) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^	15	^	16	^
SP1:																							-						-				-				-
SP2:
SP3:
SP4:																							-		-		-		-				-				-
SP5:											-

ExUns:	17	^	18	^	19a	·	19b	^	20a	·	20b	·	20c	^	21	^	22	^	23a	·	23b	^	24a	·	24b	^	25	^	26
SP1:									-		-
SP2:									-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DNMT3A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DNMT3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATAACCCT

About this image

DNMT3A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Primordial germ cell-like cells (Reconstitution of mo...)

Epiblast-like cells (Reconstitution of mo...)

See DNMT3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DNMT3A

SOURCE GeneReport for Unigene cluster: Hs.515840

UniProtKB/Swiss-Prot: DNM3A_HUMAN, Q9Y6K1

Tissue specificity: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells,

kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung

SABiosciences Expression via Pathway-Focused PCR Arrays including DNMT3A:

Epigenetic Chromatin Modification Enzymes in human mouse rat

Polycomb & Trithorax Complexes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNMT3A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DNMT3A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNMT3A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNMT3A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNMT3A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DNMT3A gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DNMT3A¹	DNA (cytosine-5-)-methyltransferase 3 alpha	82.04(n) 89.15(a)		421991 NM_001024832.1 NP_001020003.1
lizard (Anolis carolinensis)	Reptilia	E5CW94_ANOCA⁶	--	93(a)	1 ↔ 1	GL343593.1(257019-273792)
tropical clawed frog (Xenopus tropicalis)	Amphibia	AL969565.2²	--	78.29(n)		AL969565.2
zebrafish (Danio rerio)	Actinopterygii	dnmt3ab¹	DNA (cytosine-5-)-methyltransferase 3 alpha b	74.95(n) 84.23(a)		553189 NM_001018140.1 NP_001018150.1
honey bee (Apis mellifera)	Insecta	-- --	--	23(a) 18(a)	many ↔ many many ↔ many	Group2.1(246578-252516) Group2.1(246777-305645)

ENSEMBL Gene Tree for DNMT3A (if available)
TreeFam Gene Tree for DNMT3A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DNMT3A gene

DNMT3L² DNMT3B²

2 SIMAP similar genes for DNMT3A using alignment to 4 protein entries: DNM3A_HUMAN (see all proteins):

DNMT3B DNMT3L

DNMT3A for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for DNMT3A
PGOHUM00000240077

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60749413^1,2	C,	--	25277627(+)	`GTTTG-/TTAACA`	1	--	int¹		1		NA	2
rs752208^1,2	C,F,A,H,	--	25455389(-)	`AGGACC/TGGCCG`	3	--	ds500¹		22		MN NS EA NA WA CSA	2502
rs189232281^1,2		--	25455486(+)	`CTGGCC/TGCCCA`	3	--	ds500¹		0	--	--	--	--
rs150488471^1,2		--	25455759(+)	`GGGGCC/TGGGAG`	3	--	ds500¹		0	--	--	--	--
rs180811074^1,2		--	25455940(+)	`GCCCTC/TGAATT`	3	--	ut3¹		0	--	--	--	--
rs186497151^1,2		--	25456119(+)	`ACCTGG/TCTCCC`	3	--	ut3¹		0	--	--	--	--
rs145421172^1,2		--	25456170(+)	`GCCCAC/TCGTGA`	3	--	ut3¹		0	--	--	--	--
rs10538^1,2	C	--	25456172(+)	`CCACCG/ATGAGA`	3	--	ut3¹		2		MN NA	186
rs188646626^1,2		--	25456387(+)	`GGCTTC/TTAGAA`	3	--	ut3¹		0	--	--	--	--
rs199673579^1,2		--	25456398(+)	`ACTGA-/TTTTCT`	3	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DNMT3A (25455845 - 25565459 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DNMT3A
3 CNVs: 97795 73090 7259
Human Gene Mutation Database (HGMD): DNMT3A

2 SABiosciences Cancer Mutation PCR Assays for DNMT3A:

Cosmic Id	AA Change
87007	p.P904L
53042	p.R882C

2 SABiosciences Cancer Mutation PCR Arrays containing DNMT3A:

Acute Myeloid Leukemia

Myelodysplastic Syndromes

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNMT3A

DNA2.0 Custom Variant and Variant Library Synthesis for DNMT3A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DNMT3A for disorders           About GeneDecksing

OMIM gene information: 602769    OMIM disorders: --

20/57 diseases for DNMT3A (see all 57):    About MalaCards

testicular germ cell tumor germ cell tumor spina bifida myelomonocytic leukemia

monocytic leukemia chronic myelomonocytic leukemia acute monocytic leukemia oral leukoplakia

systemic lupus erythematosus leukoplakia lupus erythematosus lymphosarcoma

transitional cell carcinoma acute lymphoblastic leukemia acute myeloid leukemia lymphoblastic leukemia

epithelial ovarian cancer myeloid leukemia kaposi's sarcoma ovarian cancer

1 disease from the University of Copenhagen DISEASES database for DNMT3A:

Acute myeloid leukemia

10/16 Novoseek disease relationships for DNMT3A gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	42.6	9	12015329 (2), 16682412 (1), 14555514 (1), 19139273 (1) (see all 7)
tumors	37.1	13	16870044 (1), 17408664 (1), 18253830 (1), 11496321 (1) (see all 12)
hepatocellular carcinoma	28.3	5	20467490 (2), 17549390 (1), 19139273 (1)
colon cancer	20	2	15547111 (2)
ovarian cancer	19.7	2	11531283 (2)
carcinoma	14	4	17998942 (4)
cancer lung	6.39	1	16870044 (1)
endometrial cancer	3.64	1	17556066 (1)
hepatitis chronic	3.6	4	17549390 (2), 11230735 (1)
colorectal cancer	3.21	1	19454286 (1)

Human Genome Epidemiology (HuGE) Navigator: DNMT3A (14 documents)

Export disorders for DNMT3A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DNMT3A gene, integrated from 9 sources (see all 280):
(articles sorted by number of sources associating them with DNMT3A)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, expression and chromosome locations of the human DNMT3 gene family. (PubMed id 10433969)^{1, 2, 3, 9} Xie S....Li E. (1999)
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. (PubMed id 12138111)^{1, 2, 9} Chen T.... Li E. (2002)
Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation. (PubMed id 17713477)^{1, 2, 9} Jia D....Cheng X. (2007)
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. (PubMed id 19834512)^{1, 2, 9} Otani J....Shirakawa M. (2009)
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells. (PubMed id 16682412)^{1, 2, 9} Li H.... Pfeifer G.P. (2006)
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. (PubMed id 10325416)^{1, 2, 9} Robertson K.D.... Jones P.A. (1999)
Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. (PubMed id 12145218)^{1, 2, 9} Kim G.D....Pradhan S. (2002)
Mutational spectrum analysis of chronic myelomonocyti c leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. (PubMed id 21828135)^{1, 2} Jankowska A.M....Maciejewski J.P. (2011)
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. (PubMed id 22086334)^{1, 2} Chang Y....Cheng X. (2011)
The Polycomb group protein EZH2 directly controls DNA methylation. (PubMed id 16357870)^{1, 2} Vire E.... Fuks F. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1788	HGNC: 2978	AceView: DNMT3A	Ensembl:ENSG00000119772	euGenes: HUgn1788
ECgene: DNMT3A	Kegg: 1788	H-InvDB: DNMT3A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DNMT3A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DNMT3A	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DNMT3A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DNMT3A gene:
Search GeneIP for patents involving DNMT3A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore small molecules (inhibitor) for DNMT3A
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of DNMT3A

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for DNMT3A (DNMT3A)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for DNMT3A		OriGene shRNA RFP for DNMT3A
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DNMT3A		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DNMT3A
	OriGene Protein Over-expression Lysate for DNMT3A		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DNMT3A		OriGene 3'-UTR Clone for DNMT3A
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3A		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DNMT3A
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for DNMT3A		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DNMT3A		OriGene Custom Protein Services for DNMT3A
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DNMT3A
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DNMT3A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DNMT3A
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DNMT3A
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DNMT3A
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DNMT3A

	GenScript Custom Purified and Recombinant Proteins Services for DNMT3A		GenScript cDNA clones with any tag delivered in your preferred vector for DNMT3A
	GenScript Custom Assay Services for DNMT3A		GenScript Custom Superior Antibodies Services for DNMT3A
	GenScript Custom overexpressing Cell Line Services for DNMT3A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for DNMT3A

	Regulatory tfbs in DNMT3A promoter
	Search Chromatin IP Primers for DNMT3A
	RT² qPCR Primer Assay in human, mouse, rat DNMT3A
	GNC Network for DNMT3A
	SABiosciences PCR Arrays including human, mouse, rat DNMT3A

Tocris compounds for DNMT3A

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for DNMT3A
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DNMT3A antibodies
	DNMT3A proteins
	DNMT3A lysates

	Antibodies for DNMT3A
	See all of Abcam's Antibodies, Kits and Proteins for DNMT3A
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

DNMT3A Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DNMT3A

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DNMT3A

	SwitchGear 3'UTR luciferase reporter plasmids for DNMT3A
	SwitchGear Promoter luciferase reporter plasmids for DNMT3A

ThermoFisher Antibody for DNMT3A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DNMT3A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DNMT3A gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

DNMT3A Gene

DNA (cytosine-5-)-methyltransferase 3 alpha

Aliases
for DNMT3A gene

Summaries
for DNMT3A gene

Genomic Views
for DNMT3A gene

Proteins
for DNMT3A gene

Protein Domains /
Families
for DNMT3A gene

Function
for DNMT3A gene

Pathways & Interactions
for DNMT3A gene

Drugs & Compounds
for DNMT3A gene

Transcripts
for DNMT3A gene

Expression
for DNMT3A gene

Orthologs
for DNMT3A gene

Paralogs
for DNMT3A gene

Genomic Variants
for DNMT3A gene

Disorders / Diseases
for DNMT3A gene

Publications
for DNMT3A gene

External Searches for DNMT3A gene

Genome Databases showing DNMT3A gene

Other Databases showing DNMT3A gene

Specialized Databases showing DNMT3A gene

Intellectual Property
for DNMT3A gene

Products
for DNMT3A gene

View Random Gene

Advanced Search

Export list of displayed genes

DNMT3A Gene

DNA (cytosine-5-)-methyltransferase 3 alpha

Aliasesfor DNMT3A gene

Summariesfor DNMT3A gene

Genomic Viewsfor DNMT3A gene

Proteinsfor DNMT3A gene

Protein Domains /Familiesfor DNMT3A gene

Functionfor DNMT3A gene

Pathways & Interactionsfor DNMT3A gene

Drugs & Compoundsfor DNMT3A gene

Transcriptsfor DNMT3A gene

Expression for DNMT3A gene

Orthologsfor DNMT3A gene

Paralogsfor DNMT3A gene

Genomic Variantsfor DNMT3A gene

Disorders / Diseasesfor DNMT3A gene

Publicationsfor DNMT3A gene

External Searches for DNMT3A gene

Genome Databases showing DNMT3A gene

Other Databases showing DNMT3A gene

Specialized Databases showing DNMT3A gene

Intellectual Propertyfor DNMT3A gene

Productsfor DNMT3A gene

View Random Gene

Aliases
for DNMT3A gene

Summaries
for DNMT3A gene

Genomic Views
for DNMT3A gene

Proteins
for DNMT3A gene

Protein Domains /
Families
for DNMT3A gene

Function
for DNMT3A gene

Pathways & Interactions
for DNMT3A gene

Drugs & Compounds
for DNMT3A gene

Transcripts
for DNMT3A gene

Expression
for DNMT3A gene

Orthologs
for DNMT3A gene

Paralogs
for DNMT3A gene

Genomic Variants
for DNMT3A gene

Disorders / Diseases
for DNMT3A gene

Publications
for DNMT3A gene

Intellectual Property
for DNMT3A gene

Products
for DNMT3A gene